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1. Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes

Author

Aterido, Adrià, López-Lasanta, María, Blanco, Francisco, Juan-Mas, Antonio, García-Vivar, María Luz, Erra, Alba, Pérez-García, Carolina, Sánchez-Fernández, Simón Ángel, Sanmartí, Raimon, Fernández-Nebro, Antonio, Alperi-López, Mercedes, Tornero, Jesús, Ortiz, Ana María, Fernández-Cid, Carlos Marras, Palau, Núria, Pan, Wenjing, Byrne-Steele, Miranda, Starenki, Dmytro, Weber, Daniel, Rodriguez-Nunez, Ivan, Han, Jian, Myers, Richard M., Marsal, Sara, and Julià, Antonio

Published
2024
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2. Interactions between rheumatoid arthritis antibodies are associated with the response to anti-tumor necrosis factor therapy

Author

Julià, Antonio, López-Lasanta, María, Blanco, Francisco, Gómez, Antonio, Haro, Isabel, Mas, Antonio Juan, Erra, Alba, Vivar, Ma Luz García, Monfort, Jordi, Sánchez-Fernández, Simón, González, Isidoro, Alperi, Mercedes, Castellanos-Moreira, Raúl, Fernández-Nebro, Antonio, Díaz-Torné, César, Palau, Núria, Lastra, Raquel, Lladós, Jordi, Sanmartí, Raimon, and Marsal, Sara

Published
2021
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3. Measuring inflammation in rheumatoid arthritis with a new clinical and ultrasound index: development and initial validation

Author

de Agustín, Juan José, Erra, Alba, Ponce, Andrés, Moragues, Carmen, Díaz-Torné, Cesar, Reina, Delia, Moreno, Estefanía, Ramírez, Julio, Mateo, Lourdes, Pujol Busquets, Manel, Moya, Patricia, Santo-Panero, Pilar, Ros-Expósito, Sergi, Narváez, Javier, Sanmartí, Raimon, García de Yébenes, Mª Jesús, and Carmona, Loreto

Published
2019
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4. Lipoprotein(a) concentrations in rheumatoid arthritis on biologic therapy: Results from the CARdiovascular in rheuMAtology study project

Author

de Rábago, Eugenia Gonzalez, Blanco Morales, Elena Alonso, Fernández López, J. Carlos, Villar, Natividad Oreiro, Sandoval, Antonio Atanes, Blanco García, Francisco J., De Miquel, Cayetano Alegre, González Fernández, María J., Codina, Ramón Huguet, Yoldi, Beatriz, Ramentol, Mercedes, Ávila, Gabriela, Barril, Sara Marsal, Steiner, Martina, Muñoz, Santiago, Gamero, Fernando, Torón, José García, Moreno Gil, María P., Mas, Antonio J., Espiño, Pilar, Ros, Inmaculada, Ibañez, Mónica, Murillo, Claudia, Piqueras, José A., Sanmartí, Raimon, Berman, Horacio, Cabrera, Sonia, Ruiz, Virginia, Patón, Oscar Fontseré, Gutiérrez, Benjamín Fernández, Abasolo, Lydia, Fábregas, María D., Nolla, Joan M., Arias, Miriam García, García Vadillo, Jesús A., de Vicuña, Rosario García, Nebro, Antonio Fernández, Belmonte López, Maria Angeles, Ureña, Inmaculada, Irigoyen, María V., Cagigal, Virginia Coret, González, Ruth López, Garrido, Daniel Pielfort, Alvarez, Juana Sampedro, García Aparicio, Ángel María, Gómez, Rebeca Belmonte, Bautista, Pastora Granados, Sanz, Azucena Hernández, Sánchez González, Carmen O., Bachiller, Javier, Zea, Antonio, Manero, Francisco J., Zorzo, Fernando Jimenez, Ubeda, Eugenio Giménez, Gracía, Jesús Marzo, Audera, Chesús Beltrán, Medrano, Marta, Pecondón, Ángela, Erausquin, Celia, Ojeda, Soledad, Quevedo, Juan Carlos, Francisco, Félix, Lozano, Carlos Rodríguez, Herráez, Jesús Babío, López Longo, Francisco J., Gerona, Delia, Fernández, Carlos González, Carreño, Luis, Monteagudo, Indalecio, del Pino, Javier, Sánchez González, María Dolores, Corrales, Alfonso, Peiró, María Enriqueta, Senabre, José M., Rosas, José C., Rotés, Isabel, Moreno, Estefanía, Erra, Alba, Grado, Dolors, Calvo, Javier, Rueda, Amalia, Möller, Ingrid, Rodríguez, Isabel, Barbadillo, Carmen, Raya, Enrique, Morales, Pilar, Nieto, Ana, Jiménez, Inmaculada, magro, Cesar, Escribano, Ana Ruibal, Expósito, Sergio Ros, Nievas, Ginés Sánchez, Navarro, Enrique Júdez, Fernández, Manuela Sianes, García Morales, María Ángeles, Bastero, Isabel Labiano, Consuegra, Gloria García, Palmou, Natalia, Pardo, Silvia Martínez, Pujol, Manel, Alonso, Elena Riera, Salvador, Georgina, Alvarez, Beatriz González, Cantabrana, Alberto, Bustabad, Sagrario, Delgado, Esmeralda, Muñoz, Alejandro, Montero, Sergio Rodríguez, Jiménez, Luis María, Redondo, Javier Rivera, Hernández, Teresa González, González Polo, Francisco J., Almagro, Raúl Menor, Moreno, José M., Serret, Emilio Giner, Barroso, Carla Lannuzzelli, Méndez, Laura Cebrián, Navío, María Teresa, Carballido, Cristina Fernández, Pagán, Encarnación, del Castillo, Pablo Mesa, Naredo, Esperanza, Cruz, Ana, Turrión, Ana, Mateo, Isabel, Sánchez, Julio, Galindo, María, González, Javier García, Collantes, Eduardo, Ruíz, Desireé, Font, Pilar, Bonilla, Gema, Meseguer, Antonio López, Moreno, Manuel J., Martínez, M<ce:sup loc='post">a</ce:sup> José Moreno, Fernández, M<ce:sup loc='post">a</ce:sup> Dolores Beteta, Linares, Luis F., Morcillo, Mercedes, González Gómez, María L., Aramburu, José M., Rivera, Natalia A., Berrizbeitia, Olaia Fernández, García Vivar, María Luz, Riera, Manel, León, Yolanda María, Maymó, Joan, Amirall, Miriam, Escolano, Silvia Iniesta, Serrano, Silvia Sánchez, Lis Bona, María Pilar, Fiter, Jordi, Melón, Julia Fernández, Espadaler, Luis, Maiz, Olga, Belzunegui, Joaquín, Bañegil, Inmaculada, Díaz, César, Valls, Ramón, Castellví, Iván, Bonet, María, Ruzafa, Estefania Moreno, Alen, Jaime Calvo, Sandoval, Trinidad Pérez, Evrard, Eva Revuelta, Godo, Javier R., Espartero, Cruz Fernández, Navarro Blasco, Francisco J., González, José Antonio, Miranda-Filloy, José A., García-Gómez, Carmen, Martín-Martínez, Maria A., Castañeda, Santos, Sanchez-Alonso, Fernando, Uriarte-Ecenarro, Miren, González-Juanatey, Carlos, Romera-Baures, Montserrat, Santos-Rey, José, Pinto-Tasende, José Antonio, Quesada-Masachs, Estefanía, Tornero-Molina, Jesús, Martínez-González, Olga, Cobo-Ibáñez, Tatiana, Chamizo-Carmona, Eugenio, Manrique-Arija, Sara, Fábregas-Canales, Dolores, Díaz-González, Federico, Llorca, Javier, and González-Gay, Miguel A.

Published
2017
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6. Nailfold capillaroscopic findings in primary Sjögren’s syndrome with and without Raynaud’s phenomenon and/or positive anti-SSA/Ro and anti-SSB/La antibodies

Author

Corominas, Hèctor, Ortiz-Santamaría, Vera, Castellví, Iván, Moreno, Mireia, Morlà, Rosa, Clavaguera, Teresa, Erra, Alba, Martínez-Pardo, Silvia, Ordóñez, Sergi, Santo, Pilar, Reyner, Patricia, González, Maria José, Codina, Oriol, Gelman, Mario Saul, Juanola-Roura, Xavier, Olivé, Alex, Torrente-Segarra, Vicenç, and CapiCAT group

Published
2016
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7. Longitudinal analysis of blood DNA methylation identifies mechanisms of response to tumor necrosis factor inhibitor therapy in rheumatoid arthritis

Author

Julià, Antonio, primary, Gómez, Antonio, additional, López-Lasanta, María, additional, Blanco, Francisco, additional, Erra, Alba, additional, Fernández-Nebro, Antonio, additional, Mas, Antonio Juan, additional, Pérez-García, Carolina, additional, Vivar, Ma Luz García, additional, Sánchez-Fernández, Simón, additional, Alperi-López, Mercedes, additional, Sanmartí, Raimon, additional, Ortiz, Ana María, additional, Fernandez-Cid, Carlos Marras, additional, Díaz-Torné, César, additional, Moreno, Estefania, additional, Li, Tianlu, additional, Martínez-Mateu, Sergio H., additional, Absher, Devin M., additional, Myers, Richard M., additional, Molina, Jesús Tornero, additional, and Marsal, Sara, additional

Published
2022
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8. Longitudinal analysis of blood DNA methylation identifies mechanisms of response to tumor necrosis factor inhibitor therapy in rheumatoid arthritis

Author

Juliá, Antonio, Gómez, Antonio, López-Lasanta, María, Blanco García, Francisco J, Erra, Alba, Fernández-Nebro, Antonio, Juan Mas, Antonio, Pérez-García, Carolina, García Vivar, María Luz, Sánchez-Fernández, Simón, Alperi-López, Mercedes, Sanmartí, Raimon, Ortiz, Ana María, Marras Fernández-Cid, Carlos, Díaz-Torné, César, Moreno, Estefanía, Li, Tianlu, Martínez-Mateu, Sergio H., Absher, Devin M., Myers, Richard M., Tornero Molina, Jesús, Marsal, Sara, Juliá, Antonio, Gómez, Antonio, López-Lasanta, María, Blanco García, Francisco J, Erra, Alba, Fernández-Nebro, Antonio, Juan Mas, Antonio, Pérez-García, Carolina, García Vivar, María Luz, Sánchez-Fernández, Simón, Alperi-López, Mercedes, Sanmartí, Raimon, Ortiz, Ana María, Marras Fernández-Cid, Carlos, Díaz-Torné, César, Moreno, Estefanía, Li, Tianlu, Martínez-Mateu, Sergio H., Absher, Devin M., Myers, Richard M., Tornero Molina, Jesús, and Marsal, Sara

Abstract

[Abstract] Background: Rheumatoid arthritis (RA) is a chronic, immune-mediated inflammatory disease of the joints that has been associated with variation in the peripheral blood methylome. In this study, we aim to identify epigenetic variation that is associated with the response to tumor necrosis factor inhibitor (TNFi) therapy. Methods: Peripheral blood genome-wide DNA methylation profiles were analyzed in a discovery cohort of 62 RA patients at baseline and at week 12 of TNFi therapy. DNA methylation of individual CpG sites and enrichment of biological pathways were evaluated for their association with drug response. Using a novel cell deconvolution approach, altered DNA methylation associated with TNFi response was also tested in the six main immune cell types in blood. Validation of the results was performed in an independent longitudinal cohort of 60 RA patients. Findings: Treatment with TNFi was associated with significant longitudinal peripheral blood methylation changes in biological pathways related to RA (FDR<0.05). 139 biological functions were modified by therapy, with methylation levels changing systematically towards a signature similar to that of healthy controls. Differences in the methylation profile of T cell activation and differentiation, GTPase-mediated signaling, and actin filament organization pathways were associated with the clinical response to therapy. Cell type deconvolution analysis identified CpG sites in CD4+T, NK, neutrophils and monocytes that were significantly associated with the response to TNFi. Interpretation: Our results show that treatment with TNFi restores homeostatic blood methylation in RA. The clinical response to TNFi is associated to methylation variation in specific biological pathways, and it involves cells from both the innate and adaptive immune systems.

Published
2022

9. Seven chain adaptive immune receptor repertoire analysis in rheumatoid arthritis: association to disease and clinically relevant phenotypes

Author

Aterido, Adria, primary, Lopez-Lasanta, Maria, additional, Blanco, Francisco, additional, Juan-Mas, Antonio, additional, Garcia-Vivar, Maria Luz, additional, Erra, Alba, additional, Perez-Garcia, Carolina, additional, Sanchez-Fernandez, Simon Angel, additional, Sanmarti, Raimon, additional, Fernandez-Nebro, Antonio, additional, Alperi-Lopez, Mercedes, additional, Tornero, Jesus, additional, Ortiz, Ana Maria, additional, Fernandez-Cid, Carlos Marras, additional, Palau, Nuria, additional, Pan, Wenjing, additional, Byrne-Steele, Miranda, additional, Starenki, Dmytro, additional, Weber, Daniel, additional, Rodriguez-Nunez, Ivan, additional, Han, Jian, additional, Myers, Richard M, additional, Marsal, Sara, additional, and Julia, Antonio, additional

Published
2021
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10. Identification of IRX1 as a Risk Locus for Rheumatoid Factor Positivity in Rheumatoid Arthritis in a Genome-Wide Association Study

Author

Julià, Antonio, Blanco, Francisco, Fernández-Gutierrez, Benjamín, González, Antonio, Cañete, Juan D., Maymó, Joan, Alperi-López, Mercedes, Olivè, Alex, Corominas, Héctor, Martínez-Taboada, Víctor, González-Álvaro, Isidoro, Fernandez-Nebro, Antonio, Erra, Alba, Sánchez-Fernández, Simón, Alonso, Arnald, López-Lasanta, María, Tortosa, Raül, Codó, Laia, Lluis Gelpi, Josep, García-Montero, Andrés C., Bertranpetit, Jaume, Absher, Devin, Myers, Richard M., Tornero, Jesús, and Marsal, Sara

Published
2016
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11. A deletion at ADAMTS9-MAGI1 locus is associated with psoriatic arthritis risk

Author

Julià, Antonio, Pinto, José Antonio, Gratacós, Jordi, Queiró, Rubén, Ferrándiz, Carlos, Fonseca, Eduardo, Montilla, Carlos, Torre-Alonso, Juan Carlos, Puig, Lluís, Pérez Venegas, José Javier, Fernández Nebro, Antonio, Fernández, Emilia, Muñoz-Fernández, Santiago, Daudén, Esteban, González, Carlos, Roig, Daniel, Sánchez Carazo, José Luís, Zarco, Pedro, Erra, Alba, López Estebaranz, José Luís, Rodríguez, Jesús, Ramírez, David Moreno, de la Cueva, Pablo, Vanaclocha, Francisco, Herrera, Enrique, Castañeda, Santos, Rubio, Esteban, Salvador, Georgina, Díaz-Torné, César, Blanco, Ricardo, Willisch Domínguez, Alfredo, Mosquera, José Antonio, Vela, Paloma, Tornero, Jesús, Sánchez-Fernández, Simón, Corominas, Héctor, Ramírez, Julio, López-Lasanta, María, Tortosa, Raül, Palau, Nuria, Alonso, Arnald, García-Montero, Andrés C, Gelpí, Josep Lluís, Codó, Laia, Day, Kenneth, Absher, Devin, Myers, Richard M, Cañete, Juan D, and Marsal, Sara

Published
2015
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12. PDE3A-SLCO1C1 locus is associated with response to anti-tumor necrosis factor therapy in psoriatic arthritis

Author

Julià, Antonio, Rodríguez, Jesús, Fernández-Sueiro, José Luis, Gratacós, Jordi, Queiró, Rubén, Montilla, Carlos, Torre-Alonso, Juan Carlos, Pérez-Venegas, José Javier, Manrique-Arija, Sara, Muñoz-Fernández, Santiago, González, Carlos, Roig, Daniel, Zarco, Pedro, Erra, Alba, Castañeda, Santos, García, Alicia, Salvador, Georgina, Díaz-Torne, César, Blanco, Ricardo, Domínguez, Alfredo Willisch, Mosquera, José Antonio, Vela, Paloma, Tornero, Jesús, Sánchez-Fernández, Simón, Corominas, Héctor, Ramírez, Julio, Ávila, Gabriela, Alonso, Arnald, Tortosa, Raül, López-Lasanta, María, Cañete, Juan D, and Marsal, Sara

Published
2014
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13. Additional file 1 of Interactions between rheumatoid arthritis antibodies are associated with the response to anti-tumor necrosis factor therapy

Author

Julià, Antonio, López-Lasanta, María, Blanco, Francisco, Gómez, Antonio, Haro, Isabel, Mas, Antonio Juan, Erra, Alba, Vivar, Ma Luz García, Monfort, Jordi, Simón Sánchez-Fernández, González, Isidoro, Alperi, Mercedes, Castellanos-Moreira, Raúl, Fernández-Nebro, Antonio, Díaz-Torné, César, Palau, Núria, Lastra, Raquel, Lladós, Jordi, Sanmartí, Raimon, and Marsal, Sara

Abstract

Additional file 1: Supplementary Table S1. Association results for the four antibodies and anti-TNF response at week 12 in the prospective cohort (independent effects).

Published
2021
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14. Interactions Between Rheumatoid Arthritis Antibodies Are Associated With the Response to Anti-tumor Necrosis Factor Therapy

Author

Julià, Antonio, primary, López-Lasanta, Maria, additional, Blanco, Francisco, additional, Gómez, Antonio, additional, Haro, Isabel, additional, Mas, Antonio Juan, additional, Erra, Alba, additional, Vivar, Maria Luz García, additional, Monfort, Jordi, additional, Sánchez-Fernández, Simón, additional, González, Isidoro, additional, Alperi, Mercedes, additional, Castellanos-Moreira, Raúl, additional, Fernández-Nebro, Antonio, additional, Díaz-Torné, César, additional, Palau, Núria, additional, Lastra, Raquel, additional, Lladós, Jordi, additional, Sanmartí, Raimon, additional, and Marsal, Sara, additional

Published
2021
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15. GWAS replication study confirms the association of PDE3A–SLCO1C1 with anti-TNF therapy response in rheumatoid arthritis

Author

Acosta-Colman, Isabel, Palau, Núria, Tornero, Jesús, Fernández-Nebro, Antonio, Blanco, Francisco, González-Alvaro, Isidoro, Cañete, Juan D, Maymó, Joan, Ballina, Javier, Fernández-Gutiérrez, Benjamín, Olivé, Alex, Corominas, Héctor, Erra, Alba, Canela-Xandri, Oriol, Alonso, Arnald, López Lasanta, Maria, Tortosa, Raül, Julià, Antonio, and Marsal, Sara

Published
2013
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16. Risk variants for psoriasis vulgaris in a large case–control collection and association with clinical subphenotypes

Author

Julià, Antonio, Tortosa, Raül, Hernanz, José Manuel, Cañete, Juan D., Fonseca, Eduardo, Ferrándiz, Carlos, Unamuno, Pablo, Puig, Lluís, Fernández-Sueiro, José Luís, Sanmartí, Raimon, Rodríguez, Jesús, Gratacós, Jordi, Dauden, Esteban, Sánchez-Carazo, José Luís, López-Estebaranz, José Luís, Moreno-Ramírez, David, Queiró, Rubén, Montilla, Carlos, Torre-Alonso, Juan Carlos, Pérez-Venegas, José Javier, Vanaclocha, Francisco, Herrera, Enrique, Muñoz-Fernández, Santiago, González, Carlos, Roig, Daniel, Erra, Alba, Acosta, Isabel, Fernández-Nebro, Antonio, Zarco, Pedro, Alonso, Arnald, López-Lasanta, María, García-Montero, Andrés, Gelpí, Josep Lluís, Absher, Devin, and Marsal, Sara

Published
2012
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17. Incidence of COVID-19 in a cohort of adult and paediatric patients with rheumatic diseases treated with targeted biologic and synthetic disease-modifying anti-rheumatic drugs

Author

Michelena, Xabier, primary, Borrell, Helena, additional, López-Corbeto, Mireia, additional, López-Lasanta, María, additional, Moreno, Estefanía, additional, Pascual-Pastor, María, additional, Erra, Alba, additional, Serrat, Mayte, additional, Espartal, Esther, additional, Antón, Susana, additional, Añez, Gustavo Adolfo, additional, Caparrós-Ruiz, Raquel, additional, Pluma, Andrea, additional, Trallero-Araguás, Ernesto, additional, Barceló-Bru, Mireia, additional, Almirall, Miriam, additional, De Agustín, Juan José, additional, Lladós, Jordi, additional, Julià, Antonio, additional, and Marsal, Sara, additional

Published
2020
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20. Blood RNA sequencing reveals immunological processes associated with the response to abatacept in rheumatoid arthritis

Author

Julià, Antonio, López Lasanta, María, Gómez, Antonio, Sanmartí, Raimon, Marras, Carlos, Pina Salvador, José Manuel, Romero Yuste, Susana, Veiga Cabello, Raúl María, Navarro, Pilar, Moragues Pastor, Carme, Martínez Pardo, Silvia, De-Toro, Javier, Sánchez, Amalia, Cerda, Dacia, Prada, Alejandro, Erra, Alba, Monfort, Jordi, Urruticoechea-Arana, Ana, Palau, Núria, Lastra, Raquel M., Tortosa, Raúl, Pluma Sanjurjo, Andrea, and Marsal, Sara

Abstract

Resumen

Published
2019

21. Incidence of first cardiovascular event in Spanish patients with inflammatory rheumatic diseases: prospective data from the CARMA Project

Author

Martin-Martinez, M. A., Castaneda, S., Gonzalez-Juanatey, C., Sanchez-Alonso, F., Garcia-Gomez, C., Lopez-Gonzalez, R., Babio-Herraiz, J., Juan-Mas, A., Moreno-Gil, M. P., Sanchez-Gonzalez, C. O., Romera-Baures, M., Pinto-Tasende, J. A., Tornero-Molina, J., Fabregas-Canales, D., Llorca, J., Gonzalez-Gay, M. A., Gonzalez Rabago, Eugenia, Blanco Morales, Elena Alonso, Fernandez Lopez, J. Carlos, Oreiro Villar, Natividad, Atanes Sandoval, Antonio, Blanco Garcia, Francisco J., Alegre Miquel, Cayetano, Gonzalez Fernandez, Maria J., Huguet Codina, Ramon, Yoldi, Beatriz, Ramentol, Mercedes, Avila, Gabriela, Marsal Barril, Sara, Quesada, Estefania, Steiner, Martina, Munoz, Santiago, Cobo, Tatiana, Gamero, Fernando, Garcia Toron, Jose, Espino, Pilar, Ros, Inmaculada, Ibanez, Monica, Murillo, Claudia, Sanmarti, Raimon, Berman, Horacio, Cabrera, Sonia, Ruiz, Virginia, Fontsere Paton, Oscar, Fernandez Gutierrez, Benjamin, Abasolo, Lydia, Pina, Jose M., Nolla, Joan M., Garcia Arias, Miriam, Garcia Vadillo, Jesus A., Garcia Vicuna, Rosario, Fernandez Nebro, Antonio, Manrique Arija, Sara, Belmonte Lopez, Maria A., Urena, Inmaculada, Irigoyen, Maria V., Coret Cagigal, Virginia, Pielfort Garrido, Daniel, Garcia Aparicio, Angel M., Belmonte Gomez, Rebeca, Granados Bautista, Pastora, Hernandez Sanz, Azucena, Bachiller, Javier, Manero, Francisco J., Jimenez Zorzo, Fernando, Gimenez Ubeda, Eugenio, Marzo Garcia, Jesus, Beltran Audera, Chesus, Medrano, Marta, Pecondon, Angela, Erausquin, Celia, Ojeda, Soledad, Carlos Quevedo, Juan, Francisco, Felix, Rodriguez Lozano, Carlos, Lopez Longo, Francisco J., Gerona, Delia, Gonzalez Fernandez, Carlos, Monteagudo, Indalecio, Del Pino, Javier, Sanchez Gonzalez, Maria Dolores, Corrales, Alfonso, Enriqueta Peiro, Maria, Senabre, Jose M., Rosas, Jose C., Rotes, Isabel, Moreno, Estefania, Erra, Alba, Grado, Dolors, Calvo, Javier, Rueda, Amalia, Moller, Ingrid, Rodriguez, Isabel, Barbadillo, Carmen, Raya, Enrique, Morales, Pilar, Nieto, Ana, Jimenez, Inmaculada, Magro, Cesar, Ruibal Escribano, Ana, Ros Exposito, Sergio, Sanchez Nievas, Gines, Judez Navarro, Enrique, Sianes Fernandez, Manuela, Garcia Morales, Maria A., Labiano Bastero, Isabel, Garcia Consuegra, Gloria, Palmou, Natalia, Martinez Pardo, Silvia, Pujol, Manel, Riera Alonso, Elena, Salvador, Georgina, Gonzalez Alvarez, Beatriz, Cantabrana, Alberto, Bustabad, Sagrario, Delgado, Esmeralda, Alejandro Muñoz-Jiménez, Rodriguez Montero, Sergio, Jimenez, Luis M., Rivera Redondo, Javier, Gonzalez Hernandez, Teresa, Gonzalez Polo, Francisco J., Menor Almagro, Raul, Moreno, Jose M., Giner Serret, Emilio, Lannuzzelli Barroso, Carla, Cebrian Mendez, Laura, Navio, Maria T., Fernandez Carballido, Cristina, Pagan, Encarnacion, Mesa Del Castillo, Pablo, Naredo, Esperanza, Cruz, Ana, Turrion, Ana, Sanchez, Julio, Galindo, Maria, Garcia Gonzalez, Javier, Collantes, Eduardo, Ruiz, Desiree, Font, Pilar, Bonilla, Gema, Lopez Meseguer, Antonio, Moreno, Manuel J., Moreno Martinez, Maria Jose, Beteta Fernandez, Maria D., Linares, Luis F., Morcillo, Mercedes, Gonzalez Gomez, Maria L., Rivera, Natalia A., Fernandez Berrizbeitia, Olaia, Garcia Vivar, Maria L., Riera, Manel, Maria Leon, Yolanda, Maymo, Joan, Amirall, Miriam, Iniesta Escolano, Silvia, Sanchez Serrano, Silvia, Lis Bona, Maria P., Fiter, Jordi, Fernandez Melon, Julia, Espadaler, Luis, Maiz, Olga, Belzunegui, Joaquin, Banegil, Inmaculada, Diaz, Cesar, Valls, Ramon, Castellvi, Ivan, Bonet, Maria, Moreno Ruzafa, Estefania, Calvo Alen, Jaime, Perez Sandoval, Trinidad, Revuelta Evrard, Eva, Godo, Javier R., Fernandez Espartero, Cruz, Navarro Blasco, Francisco J., Gonzalez, Jose A., and Miranda-Filloy, Jose A.

Subjects
rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, incidence, cohort study, CARMA project, cardiovascular diseases
Abstract

Objective To determine the incidence and risk factors of first cardiovascular event (CVE) in patients with chronic inflammatory rheumatic diseases (CIRD). Methods Analysis of data after 2.5 years of follow-up from the prospective study CARMA project, that includes patients with CIRD [rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA)] and matched individuals without CIRD from 67 hospitals in Spain. CVE cumulative incidence per 1000 patients was calculated after 2.5 years from the start of the project. Weibull proportional hazard model was used to calculate hazard ratio (HR) and 95% confidence interval (95% CI) of the risk factors. Results 2595 (89.1%) patients completed the 2.5 years of follow-up visit. Cumulative incidence of CVE in patients with CIRD was 15.30 cases per 1000 patients (95% CI: 12.93-17.67), being higher in the subgroup with AS; 22.03 (95% CI: 11.01-33.04). Patients with AS (HR: 4.11; 95% CI: 1.07-15.79), those with older age (HR: 1.09; 95% CI: 1.05-1.13), systolic hypertension (HR: 1.02; 95% CI: 1.00-1.04) and long duration of the disease (HR: 1.07; 95% CI: 1.03-1.12) were at higher risk of first CVE during the 2.5 years of follow-up. In contrast, female gender was a protective factor (HR: 0.43; 95% CI: 0.18-1.00). Conclusion Among CIRD patients prospectively followed-up at rheumatology outpatient clinics, those with AS show higher risk of first CVE. Besides cardiovascular risk factors, such as hypertension, being a man and older

Published
2019

23. A combined transcriptomic and genomic analysis identifies a gene signature associated with the response to anti-TNF therapy in rheumatoid arthritis

Author

Aterido, Adriá, Cañete, Juan D., Tornero, Jesús, Blanco García, Francisco J, Fernández-Gutiérrez, Benjamín, Pérez, Carolina, Alperi-López, Mercedes, Olivé, Alex, Corominas, Héctor, Martínez-Taboada, Víctor, González, Isidoro, Fernández-Nebro, Antonio, Erra, Alba, López-Lasanta, María, López-Corbeto, Mireia, Palau, Núria, Juliá, Antonio, Marsal, Sara, Aterido, Adriá, Cañete, Juan D., Tornero, Jesús, Blanco García, Francisco J, Fernández-Gutiérrez, Benjamín, Pérez, Carolina, Alperi-López, Mercedes, Olivé, Alex, Corominas, Héctor, Martínez-Taboada, Víctor, González, Isidoro, Fernández-Nebro, Antonio, Erra, Alba, López-Lasanta, María, López-Corbeto, Mireia, Palau, Núria, Juliá, Antonio, and Marsal, Sara

Abstract

[Abstract] Background: Rheumatoid arthritis (RA) is the most frequent autoimmune disease involving the joints. Although anti-TNF therapies have proven effective in the management of RA, approximately one third of patients do not show a significant clinical response. The objective of this study was to identify new genetic variation associated with the clinical response to anti-TNF therapy in RA. Methods: We performed a sequential multi-omic analysis integrating different sources of molecular information. First, we extracted the RNA from synovial biopsies of 11 RA patients starting anti-TNF therapy to identify gene coexpression modules (GCMs) in the RA synovium. Second, we analyzed the transcriptomic association between each GCM and the clinical response to anti-TNF therapy. The clinical response was determined at week 14 using the EULAR criteria. Third, we analyzed the association between the GCMs and anti-TNF response at the genetic level. For this objective, we used genome-wide data from a cohort of 348 anti-TNF treated patients from Spain. The GCMs that were significantly associated with the anti-TNF response were then tested for validation in an independent cohort of 2,706 anti-TNF treated patients. Finally, the functional implication of the validated GCMs was evaluated via pathway and cell type epigenetic enrichment analyses. Results: A total of 149 GCMs were identified in the RA synovium. From these, 13 GCMs were found to be significantly associated with anti-TNF response (P < 0.05). At the genetic level, we detected two of the 13 GCMs to be significantly associated with the response to adalimumab (P = 0.0015) and infliximab (P = 0.021) in the Spain cohort. Using the independent cohort of RA patients, we replicated the association of the GCM associated with the response to adalimumab (P = 0.0019). The validated module was found to be significantly enriched for genes involved in the nucleotide metabolism (P = 2.41e-5) and epigenetic marks from immune cells, incl

Published
2019

25. A Combined Transcriptomic and Genomic Analysis Identifies a Gene Signature Associated With the Response to Anti-TNF Therapy in Rheumatoid Arthritis

Author

Aterido, Adrià, primary, Cañete, Juan D., additional, Tornero, Jesús, additional, Blanco, Francisco, additional, Fernández-Gutierrez, Benjamín, additional, Pérez, Carolina, additional, Alperi-López, Mercedes, additional, Olivè, Alex, additional, Corominas, Héctor, additional, Martínez-Taboada, Víctor, additional, González, Isidoro, additional, Fernández-Nebro, Antonio, additional, Erra, Alba, additional, López-Lasanta, María, additional, López Corbeto, Mireia, additional, Palau, Núria, additional, Marsal, Sara, additional, and Julià, Antonio, additional

Published
2019
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27. SAT0020 BLOOD RNA SEQUENCING REVEALS IMMUNOLOGICAL PROCESSES ASSOCIATED WITH THE RESPONSE TO ABATACEPT IN RHEUMATOID ARTHRITIS

Author

Julià, Antonio, primary, Lasanta, Maria Lopez, additional, Gómez, Antonio, additional, Sanmarti, Raimon, additional, Fernandez Cid, Carlos Marras, additional, Pina Salvador, José Manuel, additional, Romero-Yuste, Susana, additional, Veiga Cabello, Raul Maria, additional, Navarro, Pilar, additional, Pastor, Carme Moragues, additional, Pardo, Silvia Martinez, additional, Toro-Santos, Javier de, additional, Sánchez, Amalia, additional, Cerda, Dacia, additional, Prada, Alejandro, additional, Erra, Alba, additional, Monfort, Jordi, additional, Urruticoechea-Arana, Ana, additional, Palau, Núria, additional, Lastra, Raquel M., additional, Tortosa, Raül, additional, Sanjurjo, Andrea Pluma, additional, and Marsal, Sara, additional

Published
2019
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28. SAT0616 DIETARY HABITS OF SIX AUTOIMMUNE DISEASES IN THE SPANISH POPULATION: A CROSS-SECTIONAL STUDY

Author

Julià, Antonio, primary, Martinez, Sergio Hilario, additional, Tornero, Jesús, additional, Cañete, Juan D., additional, Fernandez-Nebro, Antonio, additional, Blanco, Francisco, additional, Rodríguez, Jesús, additional, López-Longo, Francisco J., additional, Fernández-Gutiérrez, Benjamín, additional, Gratacós, Jordi, additional, Pérez Venegas, José Javier, additional, Pérez, Carolina, additional, Silva, Rubén Queiró, additional, Olive, Alejandro, additional, Alperi-López, Mercedes, additional, Montilla-Morales, Carlos A., additional, Andreu, Jose Luis, additional, Torre-Alonso, Juan Carlos, additional, Ángeles Aguirre-Zamorano, M, additional, Corominas, Héctor, additional, Casasempere, Paloma Vela, additional, Taboada, Victor Martinez, additional, Arija, Sara Manrique, additional, Nolla, Joan Miquel, additional, González-Álvaro, Isidoro, additional, Muñoz-Fernández, Santiago, additional, Marenco, Jose Luis, additional, González, Carlos M., additional, Zea, Antonio, additional, Lasanta, Maria Lopez, additional, Roig, Daniel, additional, Pego-Reigosa, Jose M., additional, Corbeto, Mireia Lopez, additional, Zarco-Montejo, Pedro, additional, González, Mercedes Freire, additional, Erra, Alba, additional, Alvarez, Elvira Diez, additional, Castañeda, Santos, additional, Almaraz, Esther Rodríguez, additional, García, Alicia, additional, Carreira, Patricia, additional, Alarcon, Georgina Salvador, additional, Torne, Cesar Diaz, additional, Blanco, Ricardo, additional, Dominguez, Alfredo Willisch, additional, Mosquera Martínez, José Antonio, additional, Fernandez, Simon Sánchez, additional, Ramirez, Julio, additional, and Marsal, Sara, additional

Published
2019
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29. Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis

Author

Aterido, Adrià, primary, Cañete, Juan D, additional, Tornero, Jesús, additional, Ferrándiz, Carlos, additional, Pinto, José Antonio, additional, Gratacós, Jordi, additional, Queiró, Rubén, additional, Montilla, Carlos, additional, Torre-Alonso, Juan Carlos, additional, Pérez-Venegas, José J, additional, Fernández Nebro, Antonio, additional, Muñoz-Fernández, Santiago, additional, González, Carlos M, additional, Roig, Daniel, additional, Zarco, Pedro, additional, Erra, Alba, additional, Rodríguez, Jesús, additional, Castañeda, Santos, additional, Rubio, Esteban, additional, Salvador, Georgina, additional, Díaz-Torné, Cesar, additional, Blanco, Ricardo, additional, Willisch Domínguez, Alfredo, additional, Mosquera, José Antonio, additional, Vela, Paloma, additional, Sánchez-Fernández, Simon Angel, additional, Corominas, Héctor, additional, Ramírez, Julio, additional, de la Cueva, Pablo, additional, Fonseca, Eduardo, additional, Fernández, Emilia, additional, Puig, Lluis, additional, Dauden, Esteban, additional, Sánchez-Carazo, José Luís, additional, López-Estebaranz, José Luís, additional, Moreno, David, additional, Vanaclocha, Francisco, additional, Herrera, Enrique, additional, Blanco, Francisco, additional, Fernández‐Gutiérrez, Benjamín, additional, González, Antonio, additional, Pérez-García, Carolina, additional, Alperi‐López, Mercedes, additional, Olivé Marques, Alejandro, additional, Martínez‐Taboada, Víctor, additional, González-Álvaro, Isidoro, additional, Sanmartí, Raimon, additional, Tomás Roura, Carlos, additional, García-Montero, Andrés C, additional, Bonàs-Guarch, Sílvia, additional, Mercader, Josep Maria, additional, Torrents, David, additional, Codó, Laia, additional, Gelpí, Josep Lluís, additional, López-Corbeto, Mireia, additional, Pluma, Andrea, additional, López-Lasanta, Maria, additional, Tortosa, Raül, additional, Palau, Nuria, additional, Absher, Devin, additional, Myers, Richard, additional, Marsal, Sara, additional, and Julià, Antonio, additional

Published
2018
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30. Concordance between direct and indirect measurements of free 25-OH vitamin D

Author

Peris, Pilar, primary, Filella, Xavier, additional, Monegal, Ana, additional, Guañabens, Nuria, additional, Foj, Laura, additional, Bonet, María, additional, Boquet, Dolors, additional, Casado, Enrique, additional, Cerdá, Dacia, additional, Erra, Alba, additional, Gómez-Vaquero, Carmen, additional, Martínez, Silvia, additional, Montalá, Nuria, additional, Pittarch, Concepción, additional, Kanterewicz, Eduardo, additional, Sala, Miquel, additional, Suris, Xavier, additional, and Carrasco, Josep L., additional

Published
2017
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31. Association Between Vitamin D Status and Schizophrenia

Author

Salavert, José, primary, Grados, Dolors, additional, Ramiro, Nuria, additional, Carrión, Maria Isabel, additional, Fadeuilhe, Christian, additional, Palma, Felipe, additional, López, Laura, additional, Erra, Alba, additional, and Ramírez, Nicolás, additional

Published
2017
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32. Lipoprotein(a) concentrations in rheumatoid arthritis on biologic therapy: Results from the CARdiovascular in rheuMAtology study project

Author

García-Gómez, Carmen, primary, Martín-Martínez, Maria A., additional, Castañeda, Santos, additional, Sanchez-Alonso, Fernando, additional, Uriarte-Ecenarro, Miren, additional, González-Juanatey, Carlos, additional, Romera-Baures, Montserrat, additional, Santos-Rey, José, additional, Pinto-Tasende, José Antonio, additional, Quesada-Masachs, Estefanía, additional, Tornero-Molina, Jesús, additional, Martínez-González, Olga, additional, Cobo-Ibáñez, Tatiana, additional, Chamizo-Carmona, Eugenio, additional, Manrique-Arija, Sara, additional, Fábregas-Canales, Dolores, additional, Díaz-González, Federico, additional, Llorca, Javier, additional, González-Gay, Miguel A., additional, de Rábago, Eugenia Gonzalez, additional, Blanco Morales, Elena Alonso, additional, Fernández López, J. Carlos, additional, Villar, Natividad Oreiro, additional, Sandoval, Antonio Atanes, additional, Blanco García, Francisco J., additional, De Miquel, Cayetano Alegre, additional, González Fernández, María J., additional, Codina, Ramón Huguet, additional, Yoldi, Beatriz, additional, Ramentol, Mercedes, additional, Ávila, Gabriela, additional, Barril, Sara Marsal, additional, Steiner, Martina, additional, Muñoz, Santiago, additional, Gamero, Fernando, additional, Torón, José García, additional, Moreno Gil, María P., additional, Mas, Antonio J., additional, Espiño, Pilar, additional, Ros, Inmaculada, additional, Ibañez, Mónica, additional, Murillo, Claudia, additional, Piqueras, José A., additional, Sanmartí, Raimon, additional, Berman, Horacio, additional, Cabrera, Sonia, additional, Ruiz, Virginia, additional, Patón, Oscar Fontseré, additional, Gutiérrez, Benjamín Fernández, additional, Abasolo, Lydia, additional, Fábregas, María D., additional, Nolla, Joan M., additional, Arias, Miriam García, additional, García Vadillo, Jesús A., additional, de Vicuña, Rosario García, additional, Nebro, Antonio Fernández, additional, Belmonte López, Maria Angeles, additional, Ureña, Inmaculada, additional, Irigoyen, María V., additional, Cagigal, Virginia Coret, additional, González, Ruth López, additional, Garrido, Daniel Pielfort, additional, Alvarez, Juana Sampedro, additional, García Aparicio, Ángel María, additional, Gómez, Rebeca Belmonte, additional, Bautista, Pastora Granados, additional, Sanz, Azucena Hernández, additional, Sánchez González, Carmen O., additional, Bachiller, Javier, additional, Zea, Antonio, additional, Manero, Francisco J., additional, Zorzo, Fernando Jimenez, additional, Ubeda, Eugenio Giménez, additional, Gracía, Jesús Marzo, additional, Audera, Chesús Beltrán, additional, Medrano, Marta, additional, Pecondón, Ángela, additional, Erausquin, Celia, additional, Ojeda, Soledad, additional, Quevedo, Juan Carlos, additional, Francisco, Félix, additional, Lozano, Carlos Rodríguez, additional, Herráez, Jesús Babío, additional, López Longo, Francisco J., additional, Gerona, Delia, additional, Fernández, Carlos González, additional, Carreño, Luis, additional, Monteagudo, Indalecio, additional, del Pino, Javier, additional, Sánchez González, María Dolores, additional, Corrales, Alfonso, additional, Peiró, María Enriqueta, additional, Senabre, José M., additional, Rosas, José C., additional, Rotés, Isabel, additional, Moreno, Estefanía, additional, Erra, Alba, additional, Grado, Dolors, additional, Calvo, Javier, additional, Rueda, Amalia, additional, Möller, Ingrid, additional, Rodríguez, Isabel, additional, Barbadillo, Carmen, additional, Raya, Enrique, additional, Morales, Pilar, additional, Nieto, Ana, additional, Jiménez, Inmaculada, additional, magro, Cesar, additional, Escribano, Ana Ruibal, additional, Expósito, Sergio Ros, additional, Nievas, Ginés Sánchez, additional, Navarro, Enrique Júdez, additional, Fernández, Manuela Sianes, additional, García Morales, María Ángeles, additional, Bastero, Isabel Labiano, additional, Consuegra, Gloria García, additional, Palmou, Natalia, additional, Pardo, Silvia Martínez, additional, Pujol, Manel, additional, Alonso, Elena Riera, additional, Salvador, Georgina, additional, Alvarez, Beatriz González, additional, Cantabrana, Alberto, additional, Bustabad, Sagrario, additional, Delgado, Esmeralda, additional, Muñoz, Alejandro, additional, Montero, Sergio Rodríguez, additional, Jiménez, Luis María, additional, Redondo, Javier Rivera, additional, Hernández, Teresa González, additional, González Polo, Francisco J., additional, Almagro, Raúl Menor, additional, Moreno, José M., additional, Serret, Emilio Giner, additional, Barroso, Carla Lannuzzelli, additional, Méndez, Laura Cebrián, additional, Navío, María Teresa, additional, Carballido, Cristina Fernández, additional, Pagán, Encarnación, additional, del Castillo, Pablo Mesa, additional, Naredo, Esperanza, additional, Cruz, Ana, additional, Turrión, Ana, additional, Mateo, Isabel, additional, Sánchez, Julio, additional, Galindo, María, additional, González, Javier García, additional, Collantes, Eduardo, additional, Ruíz, Desireé, additional, Font, Pilar, additional, Bonilla, Gema, additional, Meseguer, Antonio López, additional, Moreno, Manuel J., additional, Martínez, Ma José Moreno, additional, Fernández, Ma Dolores Beteta, additional, Linares, Luis F., additional, Morcillo, Mercedes, additional, González Gómez, María L., additional, Aramburu, José M., additional, Rivera, Natalia A., additional, Berrizbeitia, Olaia Fernández, additional, García Vivar, María Luz, additional, Riera, Manel, additional, León, Yolanda María, additional, Maymó, Joan, additional, Amirall, Miriam, additional, Escolano, Silvia Iniesta, additional, Serrano, Silvia Sánchez, additional, Lis Bona, María Pilar, additional, Fiter, Jordi, additional, Melón, Julia Fernández, additional, Espadaler, Luis, additional, Maiz, Olga, additional, Belzunegui, Joaquín, additional, Bañegil, Inmaculada, additional, Díaz, César, additional, Valls, Ramón, additional, Castellví, Iván, additional, Bonet, María, additional, Ruzafa, Estefania Moreno, additional, Alen, Jaime Calvo, additional, Sandoval, Trinidad Pérez, additional, Evrard, Eva Revuelta, additional, Godo, Javier R., additional, Espartero, Cruz Fernández, additional, Navarro Blasco, Francisco J., additional, González, José Antonio, additional, and Miranda-Filloy, José A., additional

Published
2017
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33. Additional file 1: Table S1. of Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis

Author

Lopez-Lasanta, Maria, Julià, Antonio, Maymó, Joan, Fernández-Gutierrez, Benjamín, Ureña-Garnica, Inmaculada, Blanco, Francisco, Cañete, Juan, Alperi-López, Mercedes, Olivè, Alex, Corominas, Héctor, Tornero, Jesus, Erra, Alba, Almirall, Miriam, Palau, Nuria, Ortiz, Ana, Avila, Gabriela, Rodriguez-Rodriguez, Luis, Arnald Alonso, Raül Tortosa, Gonzalez-Alvaro, Isidoro, and Marsal, Sara

Subjects
musculoskeletal diseases
Abstract

Presenting the association of IL6R locus SNPs with joint damage in the discovery stage under alternative genetic models, Table S2. Presenting the association of IL6R locus SNPs with joint damage in the discovery stage according to ACPA or RF status, and Table S3. Presenting the enhancer histone marks associated with the IL6R rs4845618 SNP identified in 111 reference epigenomes from the Epigenome Roadmap Project.

Published
2015
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34. Impact of Comorbidity on Physical Function in Patients With Ankylosing Spondylitis and Psoriatic Arthritis Attending Rheumatology Clinics: Results From a Cross‐Sectional Study

Author

Fernández‐Carballido, Cristina, Martín‐Martínez, María A., García‐Gómez, Carmen, Castañeda, Santos, González‐Juanatey, Carlos, Sánchez‐Alonso, Fernando, García de Vicuña, Rosario, Erausquin‐Arruabarrena, Celia, López‐Longo, Javier, Sánchez, María D., Corrales, Alfonso, Quesada‐Masachs, Estefanía, Chamizo, Eugenio, Barbadillo, Carmen, Bachiller‐Corral, Javier, Cobo‐Ibañez, Tatiana, Turrión, Ana, Giner, Emilio, Llorca, Javier, González‐Gay, Miguel A., Gonzalez de Rabago, Eugenia, Blanco Morales, Elena Alonso, Fernández Lopez, J. Carlos, Oreiro Villar, Natividad, Atanes Sandoval, Antonio, Blanco García, Francisco J., Alegre De Miquel, Cayetano, González Fernández, María J., Codina, Ramón Huguet, Yoldi, Beatriz, Ramentol, Mercedes, Ávila, Gabriela, Marsal Barril, Sara, Steiner, Martina, Muñoz, Santiago, Gamero, Fernando, García Torón, José, Espino, Pilar, Ros, Inmaculada, Ibáñez, Mónica, Murillo, Claudia, Molina, Jesús Tornero, Sanmartí, Raimon, Berman, Horacio, Cabrera, Sonia, Ruiz, Virginia, Patón, Oscar Fontseré, Fernández Gutierrez, Benjamín, Abasolo, Lydia, Pina, Jose Manuel, Nolla, Joan M., García Arias, Miriam, Uriarte‐Ecenarro, Mirem, García Vadillo, Jesús A., Fernández Nebro, Antonio, Manrique Arija, Sara, Belmonte López, María Angeles, Ureña, Inmaculada, Irigoyen, María V., Cagigal, Virginia Coret, Garrido, Daniel Pielfort, García Aparicio, Angel María, Belmonte Gómez, Rebeca, Bautista, Pastora Granados, Hernandez Sanz, Azucena, Manero, Francisco J., Jimenez Zorzo, Fernando, Giménez Ubeda, Eugenio, Gracía, Jesús Marzo, Audera, Chesús Beltrán, Medrano, Marta, Pecondón, Ángela, Ojeda, Soledad, Quevedo, Juan Carlos, Francisco, Félix, Rodríguez Lozano, Carlos, Gerona, Delia, González Fernández, Carlos, Carreño, Luis, Monteagudo, Indalecio, Pino, Javier, Peiró, María Enriqueta, Fernández‐Carballido, Cristina, Senabre, José M., Rosas, José C., Rotés, Isabel, Moreno, Estefanía, Erra, Alba, Grado, Dolors, Calvo, Javier, Rueda, Amalia, Möller, Ingrid, Rodríguez, Isabel, Raya, Enrique, Morales, Pilar, Nieto, Ana, Jiménez, Inmaculada, Magro, Cesar, Ruibal Escribano, Ana, Expósito, Sergio Ros, Sánchez Nievas, Ginés, Navarro, Enrique Júdez, Sianes Fernández, Manuela, García Morales, María Angeles, Bastero, Isabel Labiano, Consuegra, Gloria García, Palmou, Natalia, Pardo, Silvia Martínez, Pujol, Manel, Alonso, Elena Riera, Salvador, Georgina, González Alvarez, Beatriz, Cantabrana, Alberto, Bustabad, Sagrario, Delgado, Esmeralda, Muñoz, Alejandro, Montero, Sergio Rodriguez, and Jimenez, Luis María

Abstract

To evaluate the impact of comorbidities on physical function in patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA). This was a cross‐sectional analysis of the baseline visit from the Cardiovascular in Rheumatology study. Multivariate models with physical function as the dependent variable (Bath Ankylosing Spondylitis Functional Index and Health Assessment Questionnaire for AS and PsA, respectively) were performed. Independent variables were a proxy for the Charlson Comorbidity Index (CCIp; range 0–27), sociodemographic data, disease activity (erythrocyte sedimentation rate [ESR] and Bath Ankylosing Spondylitis Disease Activity Index [BASDAI] in AS; Disease Activity Score in 28 joints [DAS28] using the ESR in PsA), disease duration, radiographic damage, and treatments. Results were reported as beta coefficients, 95% confidence intervals (95% CIs), and Pvalues. We included 738 patients with AS and 721 with PsA; 21% of patients had >1 comorbidity. Comorbidity burden (CCIp) was independently associated with worse adjusted physical function in patients with PsA (β = 0.11). Also, female sex (β = 0.14), disease duration (β = 0.01), disease activity (DAS28‐ESR; β = 0.19), and the use of nonsteroidal antiinflammatory drugs (β = 0.09), glucocorticoids (β = 0.11), and biologics (β = 0.15) were associated with worse function in patients with PsA. A higher education level was associated with less disability (β = –0.14). In patients with AS, age (β = 0.03), disease activity (BASDAI; β = 0.81), radiographic damage (β = 0.61), and the use of biologics (β = 0.51) were independently associated with worse function on multivariate analyses, but CCIp was not. The presence of comorbidities in patients with PsA is independently associated with worse physical function. The detection and control of the comorbidities may yield an integral management of the disease.

Published
2020
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35. Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis.

Author

Aterido, Adrià, Cañete, Juan D., Tornero, Jesús, Ferrándiz, Carlos, Pinto, José Antonio, Gratacós, Jordi, Queiró, Rubén, Montilla, Carlos, Torre-Alonso, Juan Carlos, Pérez-Venegas, José J., Nebro, Antonio Fernández, Muñoz-Fernández, Santiago, González, Carlos M., Roig, Daniel, Zarco, Pedro, Erra, Alba, Rodríguez, Jesús, Castañeda, Santos, Rubio, Esteban, and Salvador, Georgina

Abstract

Objective: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis affecting up to 30% of patients with psoriasis (Ps). To date, most of the known risk loci for PsA are shared with Ps, and identifying disease-specific variation has proven very challenging. The objective of the present study was to identify genetic variation specific for PsA.Methods: We performed a genome-wide association study in a cohort of 835 patients with PsA and 1558 controls from Spain. Genetic association was tested at the single marker level and at the pathway level. Meta-analysis was performed with a case-control cohort of 2847 individuals from North America. To confirm the specificity of the genetic associations with PsA, we tested the associated variation using a purely cutaneous psoriasis cohort (PsC, n=614) and a rheumatoid arthritis cohort (RA, n=1191). Using network and drug-repurposing analyses, we further investigated the potential of the PsA-specific associations to guide the development of new drugs in PsA.Results: We identified a new PsA risk single-nucleotide polymorphism at B3GNT2 locus (p=1.10e-08). At the pathway level, we found 14 genetic pathways significantly associated with PsA (pFDR<0.05). From these, the glycosaminoglycan (GAG) metabolism pathway was confirmed to be disease-specific after comparing the PsA cohort with the cohorts of patients with PsC and RA. Finally, we identified candidate drug targets in the GAG metabolism pathway as well as new PsA indications for approved drugs.Conclusion: These findings provide insights into the biological mechanisms that are specific for PsA and could contribute to develop more effective therapies. [ABSTRACT FROM AUTHOR]

Published
2019
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36. Identification ofIRX1as a Risk Locus for Rheumatoid Factor Positivity in Rheumatoid Arthritis in a Genome-Wide Association Study

Author

Julià, Antonio, primary, Blanco, Francisco, additional, Fernández-Gutierrez, Benjamín, additional, González, Antonio, additional, Cañete, Juan D., additional, Maymó, Joan, additional, Alperi-López, Mercedes, additional, Olivè, Alex, additional, Corominas, Héctor, additional, Martínez-Taboada, Víctor, additional, González-Álvaro, Isidoro, additional, Fernandez-Nebro, Antonio, additional, Erra, Alba, additional, Sánchez-Fernández, Simón, additional, Alonso, Arnald, additional, López-Lasanta, María, additional, Tortosa, Raül, additional, Codó, Laia, additional, Lluis Gelpi, Josep, additional, García-Montero, Andrés C., additional, Bertranpetit, Jaume, additional, Absher, Devin, additional, Myers, Richard M., additional, Tornero, Jesús, additional, and Marsal, Sara, additional

Published
2016
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37. A genome-wide association study identifiesSLC8A3as a susceptibility locus for ACPA-positive rheumatoid arthritis

Author

Julià, Antonio, primary, González, Isidoro, additional, Fernández-Nebro, Antonio, additional, Blanco, Francisco, additional, Rodriguez, Luis, additional, González, Antonio, additional, Cañete, Juan D., additional, Maymó, Joan, additional, Alperi-López, Mercedes, additional, Olivé, Alejandro, additional, Corominas, Héctor, additional, Martínez-Taboada, Víctor, additional, Erra, Alba, additional, Sánchez-Fernández, Simón, additional, Alonso, Arnald, additional, Lopez-Lasanta, Maria, additional, Tortosa, Raül, additional, Codó, Laia, additional, Gelpi, Josep Lluis, additional, García-Montero, Andres C., additional, Bertranpetit, Jaume, additional, Absher, Devin, additional, Bridges, S. Louis, additional, Myers, Richard M., additional, Tornero, Jesus, additional, and Marsal, Sara, additional

Published
2016
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38. Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis

Author

López-Lasanta, María, Juliá, Antonio, Maymó, Joan, Fernández-Gutiérrez, Benjamín, Ureña-Garnica, Inmaculada, Blanco García, Francisco J, Cañete, Juan D., Alperi-López, Mercedes, Olivé, Alex, Corominas, Héctor, Tornero, Jesús, Erra, Alba, Almirall, Miriam, Palau, Nuria, Ortiz, Ana, Ávila, Gabriela, Rodríguez-Rodríguez, Luis, Alonso, Arnald, Tortosa, Raül, González-Álvaro, Isidoro, Marsal, Sara, López-Lasanta, María, Juliá, Antonio, Maymó, Joan, Fernández-Gutiérrez, Benjamín, Ureña-Garnica, Inmaculada, Blanco García, Francisco J, Cañete, Juan D., Alperi-López, Mercedes, Olivé, Alex, Corominas, Héctor, Tornero, Jesús, Erra, Alba, Almirall, Miriam, Palau, Nuria, Ortiz, Ana, Ávila, Gabriela, Rodríguez-Rodríguez, Luis, Alonso, Arnald, Tortosa, Raül, González-Álvaro, Isidoro, and Marsal, Sara

Abstract

[Abstract] Introduction. Interleukin-6 (IL-6) cytokine signaling is key in Rheumatoid Arthritis (RA) pathophysiology. Blocking IL-6 receptor (IL6R) has proven to be a highly effective treatment to prevent joint damage. This study was performed to investigate the association between the genetic variation at IL6R gene and the severity of joint damage in RA. Methods. IL6R gene tagging SNPs (n = 5) were genotyped in a discovery group of 527 RA patients from 5 different university hospitals from Spain. For each marker, a linear regression analysis was performed using an additive model and adjusting for the years of evolution of the disease, autoantibody status, gender and age. Haplotypes combining the SNPs were also estimated and tested for association with the level of joint destruction. Using an independent cohort of 705 RA patients from 6 university hospitals we performed a validation study of the SNPs associated in the discovery phase. Results. In the discovery group we found a highly significant association between IL6R SNP rs4845618 and the level of joint destruction in RA (P = 0.0058, P corrected = 0.026), and a moderate association with SNP rs4453032 (P = 0.02, P corrected = 0.05). The resulting haplotype from both SNPs was more significantly associated with joint damage (P = 0.0037, P corrected = 0.011). Using the validation cohort, we replicated the association between the two IL-6R SNPs with the degree of joint destruction in RA (P = 0.007 and P = 0.04, meta-analysis P = 0.00011 and P = 0.0021, respectively), and the haplotype association (P = 0.0058, meta-analysis P = 6.64 e-5). Conclusions. Genetic variation at IL6R gene is associated with joint damage in RA.

Published
2015

39. Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis

Author

Lopez-Lasanta, Maria, primary, Julià, Antonio, additional, Maymó, Joan, additional, Fernández-Gutierrez, Benjamín, additional, Ureña-Garnica, Inmaculada, additional, Blanco, Francisco J., additional, Cañete, Juan D., additional, Alperi-López, Mercedes, additional, Olivè, Alex, additional, Corominas, Héctor, additional, Tornero, Jesus, additional, Erra, Alba, additional, Almirall, Miriam, additional, Palau, Nuria, additional, Ortiz, Ana, additional, Avila, Gabriela, additional, Rodriguez-Rodriguez, Luis, additional, Alonso, Arnald, additional, Tortosa, Raül, additional, Gonzalez-Alvaro, Isidoro, additional, and Marsal, Sara, additional

Published
2015
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40. A deletion atADAMTS9-MAGI1locus is associated with psoriatic arthritis risk

Author

Julià, Antonio, primary, Pinto, José Antonio, additional, Gratacós, Jordi, additional, Queiró, Rubén, additional, Ferrándiz, Carlos, additional, Fonseca, Eduardo, additional, Montilla, Carlos, additional, Torre-Alonso, Juan Carlos, additional, Puig, Lluís, additional, Pérez Venegas, José Javier, additional, Fernández Nebro, Antonio, additional, Fernández, Emilia, additional, Muñoz-Fernández, Santiago, additional, Daudén, Esteban, additional, González, Carlos, additional, Roig, Daniel, additional, Sánchez Carazo, José Luís, additional, Zarco, Pedro, additional, Erra, Alba, additional, López Estebaranz, José Luís, additional, Rodríguez, Jesús, additional, Ramírez, David Moreno, additional, de la Cueva, Pablo, additional, Vanaclocha, Francisco, additional, Herrera, Enrique, additional, Castañeda, Santos, additional, Rubio, Esteban, additional, Salvador, Georgina, additional, Díaz-Torné, César, additional, Blanco, Ricardo, additional, Willisch Domínguez, Alfredo, additional, Mosquera, José Antonio, additional, Vela, Paloma, additional, Tornero, Jesús, additional, Sánchez-Fernández, Simón, additional, Corominas, Héctor, additional, Ramírez, Julio, additional, López-Lasanta, María, additional, Tortosa, Raül, additional, Palau, Nuria, additional, Alonso, Arnald, additional, García-Montero, Andrés C, additional, Gelpí, Josep Lluís, additional, Codó, Laia, additional, Day, Kenneth, additional, Absher, Devin, additional, Myers, Richard M, additional, Cañete, Juan D, additional, and Marsal, Sara, additional

Published
2015
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41. Variation at FCGR2A and Functionally Related Genes Is Associated with the Response to Anti-TNF Therapy in Rheumatoid Arthritis

Author

Avila-Pedretti, Gabriela, primary, Tornero, Jesús, additional, Fernández-Nebro, Antonio, additional, Blanco, Francisco, additional, González-Alvaro, Isidoro, additional, Cañete, Juan D., additional, Maymó, Joan, additional, Alperiz, Mercedes, additional, Fernández-Gutiérrez, Benjamín, additional, Olivé, Alex, additional, Corominas, Héctor, additional, Erra, Alba, additional, Aterido, Adrià, additional, López Lasanta, María, additional, Tortosa, Raül, additional, Julià, Antonio, additional, and Marsal, Sara, additional

Published
2015
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42. Switching TNF antagonists in patients with chronic arthritis: An observational study of 488 patients over a four-year period

Author

Gomez-Reino, Juan J., Carmona, Loreto, Erra, Alba, Marsal, Sara, Castro, Mónica Fernández, Mulero, Juan, Andreu, Jose Luis, Gómez, Manuel Rodríguez, Padro, Marta Larrosa, Casado, Enrique, Leonor, Elena, Alierta, Sirvent, Reina, Delia, Gómez, Carmen García, Ibañez, Beatriz Joven, Delgado, Patricia Carreira, Hernández, Ma. Victoria, Loza, Estibaliz, Ruiz, Alberto Alonso, Itzazelaia, Esther Uriarte, Zarza, Lucia Pantoja, Aransay, Ma. Valvanera Pinillos, Hernández, Teresa Mariné, de Vicuña Pinedo, Rosario García, García, Ana Ma. Ortiz, Álvaro, Isidoro González, Laffon, Armando, Álvaro-Gracia, Jose Ma., López, César Díaz, de La Serna, Arturo Rodríguez, Cortina, Eduardo Loza, Oyarzabal, Ma. Victoria Irigoyen, Garnica, Inmaculada Ureña, Cagigal, Virginia Coret, Casasempere, Paloma Vela, Pascual, Eliseo, Serrano, Miquel Ángel Belmonte, Fabregat, Juan Beltran, Lerma, Juan José, Graña, Myriam Liz, Gómez-Reino, Juan José, Aizen, Saul Mario Gelman, Monge, Elena Ciruelo, Muriel, Eva Tomero, García, Juan Carlos Cobeta, Cuenca, Encarnación Saiz, Muñoz, José Galvez, de La Torre, Gerardo Iglesias, Pardo, Rosa Roselló, Galeano, Carlos Vázquez, de Diego, Juan Pablo Valdazo, Marsá, Xavier Tena, Santamaría, Vera Ortiz, Prada, Manuel Fernández, Piqueras, José Antonio, Tornero, Jesús, Méndez, Laura Cebrián, Carreño, Luis, Borras, Juan José García, Ruiz, Francisco Javier Manero, Busquets, Manel Pujol, Duran, Josep Granados, Cuadra, Jose Luis, Tevar, F. Javier Paulino, Huertas, Marcos Paulino, Maiz, Olga, Barastay, Estibaliz, Figueroa, Manuel, Torres, Carmen, Coro, Montserrat Corteguera, Lozano, Carlos Rodríguez, Hernández, Félix Francisco, Fernández, Iñigo Rua Figueroa, Martín, Oscar Illera, Zea Mendoza, Antonio C., de La Peña Lefebvre, Paloma García, Expósito, Marta Valero, Aznar, Emilia, Gutiérrez, Ricardo, Valenciano, Ana Cruz, Echeverria, Manuel Crespo, Del Pozo, Félix Cabero, Jimeno, Ma. Teresa Ruiz, Aresté, Jordi Fiter, Poch, Luis Espadaler, Carasa, Juan Carlos Vesga, Quintana, Eduardo Cuende, Andrada, Sagrario Sánchez, Valverde, Vicente Rodríguez, Amaro, Ivan Ferraz, García, Tomas González, Marenco, José Luis, Rejón, Eduardo, Estevez, Eduardo Collantes, Castro Villegas, M. Carmen, Hernández, Blanca, de Oca Mercader, José V. Montes, Sarabia, Federico Navarro, de Miera, Francisco Javier Toyos Saenz, Fernández-Cid, Carlos Marras, Ferran, Luis Francisco Linares, Morales, Juan Moreno, González-Montagut, Carmen, Aparicio, Ángel García, Cáliz, Rafael Cáliz, Tenorio, Carmen Idalgo, Fernández, Amalia Sánchez-Andrade, Cobo, Tatiana, Hernández, Azucena, Martín-Mola, Emilio, Fava, Xavier Arasa, Noguera Pons, José Raúl, Blasco, Francisco J. Navarro, Beltran, Juan Víctor Tovar, Gómez de Salazar, José Carlos Rosas, Soler, Gregorio Santos, Díaz, Isabel Ibero, Casado, Vega Jovani, Domenech, Raquel Martín, Barnusell, Jordi del Blanco, Hernández, Miguel Ángel Abad, Andrés, Maria Torresano, Lidon, Gaspar Pérez, Martín, Manuel Tenorio, Bañegil, Inmaculada, Guarch, Joan Maymo, García, Carolina Pérez, Carbonell, Jordi, Quevedo Vila, Víctor Eliseo, Redondo, Javier Rivera, Hernández, Teresa González, Heredia, José Manuel Rodríguez, Cid, Ángel Gallegos, Muñoz, Jesús García Arroba, Moreira, Miguel Cantalejo, Almodovar, Raquel, Donate, Javier Quiros, Montejo, Pedro Zarco, Mazzucchelli, Ramón, Martínez, Alfonso Corrales, Estruch, Dolors Boquet, Torres, Francisco Pérez, Cortes, José Ivorra, Armangue, Xavier Suris, Sandoval, Trinidad Pérez, Catalá, Javier Calvo, Campos, Cristina, Pérez, Maria Francisca Pina, Calleja, Cristina Hidalgo, Consuegra, Julia García, Muñoz, Rosa Merino, Gómez, Miquel Sala, Centellas, Montserrat, Martín, José Miguel Ruiz, Mas, Antonio Juan, Vilamajó, Inmaculada Ros, Campillo, Jaime Fernández, Molina, Rocío González, Minguez Vega, Mauricio, Tendero, Gaspar Panadero, Ruan, Jesús Ibáñez, Cristobal, Anna Martínez, Trenor, Pilar, Gil, Jenaro Graña, Peralta, Ma. Teresa Bosque, Arana, Ana Urruticoechea, Ivorra, José Román, Chalmeta, Inmaculada, López, Javier Alegre, Lario, Bonifacio Álvarez, Valdivielso, José Luis Alonso, Melón, Julia Fernández, López, Ma. Angeles Belmonte, and Montero, Dolores

Subjects
Adult, Male, Time Factors, Antibodies, Monoclonal, Humanized, Receptors, Tumor Necrosis Factor, Etanercept, Arthritis, Rheumatoid, Actuarial Analysis, Risk Factors, Humans, Spondylitis, Ankylosing, Registries, Treatment Failure, Aged, Proportional Hazards Models, Tumor Necrosis Factor-alpha, Arthritis, Arthritis, Psoriatic, Adalimumab, Antibodies, Monoclonal, Middle Aged, Infliximab, Immunoglobulin G, Chronic Disease, Retreatment, Female, Research Article
Abstract

The objective of this work is to analyze the survival of infliximab, etanercept and adalimumab in patients who have switched among tumor necrosis factor (TNF) antagonists for the treatment of chronic arthritis. BIOBADASER is a national registry of patients with different forms of chronic arthritis who are treated with biologics. Using this registry, we have analyzed patient switching of TNF antagonists. The cumulative discontinuation rate was calculated using the actuarial method. The log-rank test was used to compare survival curves, and Cox regression models were used to assess independent factors associated with discontinuing medication. Between February 2000 and September 2004, 4,706 patients were registered in BIOBADASER, of whom 68% had rheumatoid arthritis, 11% ankylosing spondylitis, 10% psoriatic arthritis, and 11% other forms of chronic arthritis. One- and two-year drug survival rates of the TNF antagonist were 0.83 and 0.75, respectively. There were 488 patients treated with more than one TNF antagonist. In this situation, survival of the second TNF antagonist decreased to 0.68 and 0.60 at 1 and 2 years, respectively. Survival was better in patients replacing the first TNF antagonist because of adverse events (hazard ratio (HR) for discontinuation 0.55 (95% confidence interval (CI), 0.34-0.84)), and worse in patients older than 60 years (HR 1.10 (95% CI 0.97-2.49)) or who were treated with infliximab (HR 3.22 (95% CI 2.13-4.87)). In summary, in patients who require continuous therapy and have failed to respond to a TNF antagonist, replacement with a different TNF antagonist may be of use under certain situations. This issue will deserve continuous reassessment with the arrival of new medications. © 2006 Gomez-Reino and Loreto Carmona; licensee BioMed Central Ltd.

Published
2006

44. A genome-wide association study identifies SLC8A3 as a susceptibility locus for ACPA-positive rheumatoid arthritis.

Author

Julià, Antonio, González, Isidoro, Fernández-Nebro, Antonio, Blanco, Francisco, Rodriguez, Luis, González, Antonio, Cañete, Juan D., Maymó, Joan, Alperi-López, Mercedes, Olivé, Alejandro, Corominas, Héctor, Martínez-Taboada, Víctor, Erra, Alba, Sánchez-Fernández, Simón, Alonso, Arnald, Lopez-Lasanta, Maria, Tortosa, Raül, Codó, Laia, Gelpi, Josep Lluis, and García-Montero, Andres C.

Subjects
RHEUMATOID arthritis risk factors, CONFIDENCE intervals, GENETIC polymorphisms, GENETICS, JOINTS (Anatomy), RESEARCH funding, DESCRIPTIVE statistics, ODDS ratio, GENOTYPES
Abstract

Objective. RA patients with serum ACPA have a strong and specific genetic background. The objective of the study was to identify new susceptibility genes for ACPA-positive RA using a genome-wide association approach. Methods. A total of 924 ACPA-positive RA patients with joint damage in hands and/or feet, and 1524 healthy controls were genotyped in 582 591 single-nucleotide polymorphisms (SNPs) in the discovery phase. In the validation phase, the most significant SNPs in the genome-wide association study representing new candidate loci for RA were tested in an independent cohort of 863 ACPA-positive patients with joint damage and 1152 healthy controls. All individuals from the discovery and validation cohorts were Caucasian and of Southern European ancestry. Results. In the discovery phase, 60 loci not previously associated with RA risk showed evidence for association at P<5x1CT-4 and were tested for replication in the validation cohort. A total of 12 loci were replicated at the nominal level (P < 0.05, same direction of effect as in the discovery phase). When combining the discovery and validation cohorts, an intronic SNP in the Solute Carrier family 8 gene (SLC8A3) was found to be associated with ACPA-positive RA at a genome-wide level of significance RA [odds ratio (95% CI): 1.42 (1.25, 1.6), Pcombined = 3.19x10-8]. Conclusions. SLC8A3 was identified as a new risk locus for ACPA-positive RA. This study demonstrates the advantage of analysing relevant subsets of RA patients to identify new genetic risk variants. [ABSTRACT FROM AUTHOR]

Published
2016
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45. Reference intervals for bone turnover markers in Spanish premenopausal women.

Author

Guañabens, Núria, Filella, Xavier, Monegal, Ana, Gómez-Vaquero, Carmen, Bonet, María, Buquet, Dolors, Casado, Enrique, Cerdá, Dacia, Erra, Alba, Martinez, Silvia, Montalá, Núria, Pitarch, Concepción, Kanterewicz, Eduardo, Sala, Miquel, Surís, Xavier, and Torres, Ferran

Subjects
MENOPAUSE treatment, PERIMENOPAUSE, OSTEOPOROSIS, URINE, COLLAGEN
Abstract

Background: The aims of this study were to establish robust reference intervals and to investigate the factors influencing bone turnover markers (BTMs) in healthy premenopausal Spanish women. Methods: A total of 184 women (35-45 years) from 13 centers in Catalonia were analyzed. Blood and second void urine samples were collected between 8 a.m. and 10 a.m. after an overnight fast. Serum procollagen type I aminoterminal propeptide (PINP) and serum cross-linked C-terminal telopeptide of type I collagen (CTX-I) were measured by two automated assays (Roche and IDS), bone alkaline phosphatase (bone ALP) by ELISA, osteocalcin (OC) by IRMA and urinary NTX-I by ELISA. PTH and 25-hydroxyvitamin D (25OHD) levels were measured. All participants completed a questionnaire on lifestyle factors. Results: Reference intervals were: PINP: 22.7-63.1 and 21.8-65.5 μg/L, bone ALP: 6.0-13.6 μg/L, OC: 8.0-23.0 μg/L, CTX-I: 137-484 and 109-544 ng/L and NTX-I: 19.6-68.9 nM/mM. Oral contraceptive pills (OCPs) influenced PINP (p = 0.007), and low body mass index (BMI) was associated with higher BTMs except for bone ALP. Women under 40 had higher median values of most BTMs. CTX-I was influenced by calcium intake (p = 0.010) and PTH (p = 0.007). 25OHD levels did not influence BTMs. Concordance between the two automated assays for PINP and particularly CTX-I was poor. Conclusions: Robust reference intervals for BTMs in a Southern European country are provided. The effects of OCPs and BMI on their levels are significant, whilst serum 25OHD levels did not influence BTMs. Age, calcium intake, BMI and PTH influenced CTX-I. The two automated assays for measuring PINP and CTX-I are not interchangeable. [ABSTRACT FROM AUTHOR]

Published
2016
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47. Genome-wide association study of rheumatoid arthritis in the Spanish population:KLF12as a risk locus for rheumatoid arthritis susceptibility

Author

Julià, Antonio, primary, Ballina, Javier, additional, Cañete, Juan D., additional, Balsa, Alejandro, additional, Tornero-Molina, Jesus, additional, Naranjo, Antonio, additional, Alperi-López, Mercedes, additional, Erra, Alba, additional, Pascual-Salcedo, Dora, additional, Barceló, Pere, additional, Camps, Jordi, additional, and Marsal, Sara, additional

Published
2008
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50. PDE3A-SLCO1C1 locus is associated with response to anti-tumor necrosis factor therapy in psoriatic arthritis.

Author

Juli, Antonio, Rodríguez, Jesús, Fernández-Sueiro, José Luis, Gratacós, Jordi, Queir, Rubén, Montilla, Carlos, Torre-Alonso, Juan Carlos, Pérez-Venegas, José Javier, Manrique-Arija, Sara, Muñoz-Fernández, Santiago, González, Carlos, Roig, Daniel, Zarco, Pedro, Erra, Alba, Castañeda, Santos, García, Alicia, Salvador, Georgina, Díaz-Torne, César, Blanco, Ricardo, and Domínguez, Alfredo Willisch

Abstract

Aim: Variation at PDE3A-SLCO1C1 locus has been recently associated with the response to anti-TNF therapy in rheumatoid arthritis. We undertook the present study to determine whether PDE3A-SLCO1C1 is also associated with the response to anti-TNF therapy in psoriatic arthritis. Patients & methods: Genomic DNA was obtained from 81 psoriatic arthritis patients that had been treated with anti-TNF therapy. PDE3A-SLCO1C1 SNP rs3794271 was genotyped using Taqman realt-time PCR. The clinical response to anti-TNF therapy was measured as the change from baseline in the level of disease activity according to the DAS28 score. Results: A significant association between rs3794271 and anti-TNF response in psoriatic arthritis was found (beta = -0.71; p = 0.0036). Conclusion: PDE3A-SLCO1C1 locus is also associated with response to anti-TNF therapy in psoriatic arthritis. Original submitted 12 May 2014; Revision submitted 18 August 2014 [ABSTRACT FROM AUTHOR]

Published
2014
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