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Intercentral relations between hypothalamus, limbic system and reticular formation were studied in rabbits and rats under systemic and central action of DSIP, ACTH, corticosteroids and stress (aggressive-defensive behaviour). The results obtained demonstrate changes in the adrenal cortex resulting from stress-inducing adrenocortical hormone content. The increase was achieved by the rise in ACTH level resulting in corticosteroid level elevation (endogenous elevation-aggressive behaviour) and by corticosteroid injections (exogenous elevation). Correlation analysis of structural interrelations after ACTH and corticosteroid injections demonstrated an increased correlation between hypothalamo-reticular-limbic structures. DSIP was shown to have an opposite effect. Correlation analysis revealed the potentials for the formation of new functional interrelations between hypothalamo-reticular-limbic structure in the motivation of aggression (stress) and the levels of corticosterone and DSIP. DSIP action depends on the initial corticosteroid blood level and is more marked in stress-inducing concentrations.

Elucidation of the mechanisms of the DSIP effect on the CNS functional state is one of the leading problems of neuroendocrinology. The investigation of DSIP physiological properties as antistress factor in systemic mechanisms of emotional stress is of great interest. The purpose of our studies was to investigate the character of changes in intercentral interrelationships among hypothalamus, limbic system and reticular formation in augmentation of corticosteroids level up to the stressful one. We also studied the character of changes in intercentral interrelationship under the DSIP effect. The latter depends on the initial level of corticosteroids in the blood and is more obvious at the stress level. DSIP, ACTH and steroid hormones facilitate the process of the self-organization of the brain as well as the formation of the current behavioral responses.