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Objective: In recent years, the importance of quality of life (QoL) in healthcare has increased significantly, particularly in the management of chronic diseases such as prostate cancer (PCa). We aimed to show the effects of functional outcomes of treatment options, such as retropubic radical prostatectomy (RRP), radiotherapy (RT), and active surveillance, on QoL in patients with localized PCa. Methods: Questionnaires on demographic characteristics, QoL, urinary incontinence (UI) level, patients' knowledge of complications before treatment, and treatment of complications were completed. Patients diagnosed with PCa were divided into three groups: RRP, RT, and RRP combined with RT. Results: There was no statistical difference between the treatment groups in terms of QoL, Mini-mental test scores, age, body mass index, prostate-specific antigen level, Charlson index, and International Society of Urological Pathology grade score, but UI scores were lower in the RT group. The most important finding was that QoL was statistically higher in patients who were informed about UI and erectile dysfunction (ED) before treatment and in patients who were treated for UI or ED after treatment. Conclusion: Our study suggests that the choice of treatment (RRP, RT, or RRP combined with RT) does not significantly affect the overall QoL of patients with localized PCa. However, patient education about potential complications, such as ED and UI, followed by appropriate treatment appears to be crucial for improving QoL after treatment.

Abstract Background Penile prosthesis implantation is the last resort for refractory erectile dysfunction. Reservoir placement is one of the biggest challenges in inflatable penile prosthesis implant surgery in several cases, especially in patients with abnormal pelvic anatomy. Ectopic reservoir placement with supramuscular approach has many advantages in these cases. Results No complications were encountered except wound site infection in 2 patients which could be controlled with antibiotic treatment. EDITS scores were not statistically different between patients divided into 2-year groups according to follow-up time. Median values of EDITS scores were high in all groups, suggesting that couples had high sexual satisfaction both in the long term and in the short term. Conclusions We recommend placement of the supramuscular tube and reservoir through the incision described, especially in patients whose pelvic anatomy has been modified by lower abdominal surgery.

Objective: The aim of this study was to determine the appropriate path to follow in the cystoscopic follow-up of patients with suspicious urine cytology but negative malignancy findings on cystoscopy. Methods: Data of 829 patients with bladder cancer between 2012 and 2023 were retrospectively analyzed. Patient data including age, gender, recurrence, progression, and urine cytology results were analyzed. Results: Approximately 65% of patients with suspicious urine cytology results had recurrence or progression of bladder cancer at subsequent follow-up. This highlights the importance of urine cytology as a screening tool and demonstrates its effectiveness as a diagnostic tool in detecting bladder cancer. However, it should be noted that even patients with suspicious urine cytology are at risk of developing bladder cancer in the future. Conclusion: Evaluation of suspicious urine cytology results is an important step in the early diagnosis of bladder cancer. Although the test has diagnostic accuracy, it should be clinically interpreted and used in conjunction with other investigations to determine the patient's cancer status.

Purpose The relationship between nutrition and overactive bladder (OAB) has yet to be elucidated. Therefore, this study investigated the relationship between the Mediterranean diet and OAB. Methods The 14-item Mediterranean Diet Adherence Screener (MeDAS) and Overactive Bladder-Validated 8-question Screener (OAB-V8), validated in Turkish, were administered to 500 patients over the age of 18 who presented to outpatient clinics other than urology outpatient clinics. Of those patients, 174 with chronic diseases and urinary tract infections (based on urinalysis and a detailed medical history) were excluded. Therefore, 326 patients’ data were analyzed. Results There was a negative correlation between the MeDAS and OAB-V8 scores. High OAB-V8 scores were associated with obesity (body mass index ≥30 kg/m2), being single, and a low education level. Conclusions Dietary patterns represent a broader perspective on food and nutrient consumption and may therefore be more predictive of disease risk. The Mediterranean type should be recommended in the first-line treatment of patients with OAB symptoms. It is easily possible to determine the compliance of patients with this diet by using the 14-item MeDAS.

Colorectal cancer is the second most common cause of cancer-related deaths worldwide and the third most common cancer overall. In this study, we investigate the anti-colon cancer potential of phytochemically, and thermally synthesised novel green carbon dots based on Rhododendron luteum (RL-CDs). A new synthesis method was used to produce carbon dots obtained from the Rhododendron luteum (RL) plant in an environmentally friendly manner. The green RL were characterized using Fourier-transform infrared spectroscopy (FTIR), UV-Vis spectroscopy, transmission electron microscopy (TEM), and artificial intelligence (AI)-based TEM analysis. The FTIR spectrum showed peaks corresponding to the hydroxyl (-OH) vibration of polyphenols at 3500 cm -1 , the C=O vibration of cellulose derivatives at 1728 cm -1 , and the C-O stretching of primary alcohol at 1041 cm -1 . Two UV absorption peaks at roughly 253 nm (UV-C range), and 320 nm (UV-B range) were observed. The size of the green RL was measured to be less than 50 nm, and its morphology was characterized as dumbbell-shaped through TEM analysis. In-vitro studies were performed with HCT116 colon cancer, MCF-7 breast cancer, and normal HUVEC cells. The results demonstrated that the RL-CDs exhibited selective cytotoxic activity against HCT116 colon cancer cells. The results show that the RL extract stimulates cancer cell death by decreasing the CD44/24 ratio, and increasing apoptotic activity. These observations suggest that green RL-CDs could be an effective anticancer agent in colon cancer therapy, investigating their potential in this direction could be a promising way for future research., (© 2025 The Authors. ChemistryOpen published by Wiley-VCH GmbH.)