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13 results on '"Ernst, Alexander U."'

3. Inflammation-induced subcutaneous neovascularization for the long-term survival of encapsulated islets without immunosuppression

Author

Wang, Long-Hai, primary, Marfil-Garza, Braulio A., additional, Ernst, Alexander U., additional, Pawlick, Rena L., additional, Pepper, Andrew R., additional, Okada, Kento, additional, Epel, Boris, additional, Viswakarma, Navin, additional, Kotecha, Mrignayani, additional, Flanders, James Arthur, additional, Datta, Ashim K., additional, Gao, Hong-Jie, additional, You, Ye-Zi, additional, Ma, Minglin, additional, and Shapiro, A. M. James, additional

Published
2023
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5. A Safe, Fibrosis‐Mitigating, and Scalable Encapsulation Device Supports Long‐Term Function of Insulin‐Producing Cells

Author

Liu, Wanjun, primary, Flanders, James A., additional, Wang, Long‐Hai, additional, Liu, Qingsheng, additional, Bowers, Daniel T., additional, Wang, Kai, additional, Chiu, Alan, additional, Wang, Xi, additional, Ernst, Alexander U., additional, Shariati, Kaavian, additional, Caserto, Julia S., additional, Parker, Benjamin, additional, Gao, Daqian, additional, Plesser, Mitchell D., additional, Grunnet, Lars G., additional, Rescan, Claude, additional, Pimentel Carletto, Rodrigo, additional, Winkel, Louise, additional, Melero‐Martin, Juan M., additional, and Ma, Minglin, additional

Published
2021
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6. A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes

Author

Wang, Xi, primary, Maxwell, Kristina G., additional, Wang, Kai, additional, Bowers, Daniel T., additional, Flanders, James A., additional, Liu, Wanjun, additional, Wang, Long-Hai, additional, Liu, Qingsheng, additional, Liu, Chengyang, additional, Naji, Ali, additional, Wang, Yong, additional, Wang, Bo, additional, Chen, Jing, additional, Ernst, Alexander U., additional, Melero-Martin, Juan M., additional, Millman, Jeffrey R., additional, and Ma, Minglin, additional

Published
2021
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7. Microtubules and motor proteins support zebrafish neuronal migration by directing cargo

Author

Theisen, Ulrike, Ernst, Alexander U., Heyne, Ronja L.S., Ring, Tobias P., Thorn-Seshold, Oliver, Köster, Reinhard W., Theisen, Ulrike, Ernst, Alexander U., Heyne, Ronja L.S., Ring, Tobias P., Thorn-Seshold, Oliver, and Köster, Reinhard W.

Abstract

Neuronal migration during development is necessary to form an ordered and functional brain. Postmitotic neurons require microtubules and dynein to move, but the mechanisms by which they contribute to migration are not fully characterized. Using tegmental hindbrain nuclei neurons in zebrafish embryos together with subcellular imaging, optogenetics, and photopharmacology, we show that, in vivo, the centrosome's position relative to the nucleus is not linked to greatest motility in this cell type. Nevertheless, microtubules, dynein, and kinesin-1 are essential for migration, and we find that interference with endosome formation or the Golgi apparatus impairs migration to a similar extent as disrupting microtubules. In addition, an imbalance in the traffic of the model cargo Cadherin-2 also reduces neuronal migration. These results lead us to propose that microtubules act as cargo carriers to control spatiotemporal protein distribution, which in turn controls motility. This adds crucial insights into the variety of ways that microtubules can support successful neuronal migration in vivo.

Published
2020

10. A Safe, Fibrosis‐Mitigating, and Scalable Encapsulation Device Supports Long‐Term Function of Insulin‐Producing Cells.

Author

Liu, Wanjun, Flanders, James A., Wang, Long‐Hai, Liu, Qingsheng, Bowers, Daniel T., Wang, Kai, Chiu, Alan, Wang, Xi, Ernst, Alexander U., Shariati, Kaavian, Caserto, Julia S., Parker, Benjamin, Gao, Daqian, Plesser, Mitchell D., Grunnet, Lars G., Rescan, Claude, Pimentel Carletto, Rodrigo, Winkel, Louise, Melero‐Martin, Juan M., and Ma, Minglin

Published
2022
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13. Hydrogels in Emerging Technologies for Type 1 Diabetes.

Author

Fuchs S, Ernst AU, Wang LH, Shariati K, Wang X, Liu Q, and Ma M

Subjects
Glucose metabolism, Humans, Insulin, Polymers, Diabetes Mellitus, Type 1 drug therapy, Hydrogels
Abstract

Type 1 diabetes therapies that afford tighter glycemic control in a more manageable and painless manner for patients has remained a central focus of next-generation diabetes therapies. In many of these emerging technologies, namely, self-regulated insulin delivery and cell replacement therapies, hydrogels are employed to mitigate some of the most long-standing challenges. In this Review, we summarize recent developments in the use of hydrogels for both insulin delivery and insulin-producing cell therapies for type 1 diabetes management. We first outline perspectives in glucose sensitive hydrogels for smart insulin delivery, pH sensitive polymeric hydrogels for oral insulin delivery, and other physiochemical signals used to trigger insulin release from hydrogels. We, then, investigate the use of hydrogels in the encapsulation of insulin secreting cells with a special emphasis on hydrogels designed to mitigate the foreign body response, provide a suitable extracellular microenvironment, and improve mass transfer through oxygen supplementation and vascularization. Evaluations of limitations and promising directions for future research are also considered. Continuing interdisciplinary and collaborative research efforts will be required to produce hydrogels with instructive biochemical microenvironments necessary to address the enduring challenges of emerging type 1 diabetes therapies.

Published
2021
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