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5 results on '"Erlan Ospanov"'

1. The Association between Parental Child Vaccination Refusal Rate and the Impact of Mass Vaccination against COVID-19 in Kazakhstan: An Interrupted Time Series Analysis with Predictive Modelling of Nationwide Data Sources from 2013 to 2022

Author

Madina Abenova, Askhat Shaltynov, Ulzhan Jamedinova, Erlan Ospanov, and Yuliya Semenova

Subjects
vaccination refusal, routine vaccine hesitancy, vaccine-preventable diseases, mandatory vaccination, vaccination confidence, COVID-19, Medicine
Abstract

Despite well-established evidence supporting vaccination efficacy in reducing morbidity and mortality among infants and children, there is a global challenge with an increasing number of childhood vaccination refusals. This issue has intensified, especially during the COVID-19 pandemic. Our study aims to forecast mandatory childhood vaccination refusal trends in Kazakhstan until 2030, assessing the impact of mass COVID-19 vaccination on these rates. Utilizing annual official statistical data from 2013 to 2022 provided by the Ministry of Health of Kazakhstan, the study reveals a significant surge in refusals during the pandemic and post-pandemic periods, reaching record levels of 42,282 cases in 2021 and 44,180 cases in 2022. Notably, refusal rates sharply rose in specific regions, like Aktobe (13.9 times increase) and Atyrau (4.29 times increase), emphasizing the need for increased public healthcare attention in these areas. However, despite a decade of data, our forecasting analysis indicates a lack of volatility in childhood vaccine refusal trends for all vaccine types up to 2030, highlighting the statistical significance of the obtained results. The increasing trend in vaccine refusals underscores the necessity to enhance crisis response and support health initiatives, particularly in regions where a substantial rise in refusals has been observed in recent years.

Published
2024
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2. Epidemiology of Prostate Cancer in the Republic of Kazakhstan

Author

Dariga SMAILOVA, Erlan OSPANOV, Meruert GAZALIYEVA, Dilyara KAIDAROVA, Oxana SHATKOVSKAYA, Zhanar ZAMANBEKOVA, Kuralay AMRENOVA, Tatyana BELIKHINA, Tasbolat ADYLKHANOV, Ardak OMARBEKOV, Marzhan DAULETYAROVA, Lyudmila PIVINA, and Yuliya SEMENOVA

Subjects
Prostate cancer, Morbidity, Mortality, Screening program, Kazakhstan, Public aspects of medicine, RA1-1270
Abstract

Background: The incidence and mortality from prostate cancer in most native Asian populations remain low although a gradual increase is observed over the last years. Methods: The statistical analysis of official data on prostate cancer mortality and morbidity was performed for the whole country and for Pavlodar Region. Results: The increase in the incidence of prostate cancer among the population of Kazakhstan is observed, which may be attributed to the introduction of screening program based on serum PSA. Still, the crude incidence rates in Kazakhstan are below world indices. Over the last few years, the decreasing prostate cancer mortality is observed that might be influenced by early diagnosis. The age-standardized incidence rates show that the majority of prostate cancer cases occur in advanced ages (70 years and older). Conclusion: More research is needed to determine the risk factors for prostate cancer, as well as ethnic and geographical trends for the population of Kazakhstan.

Published
2019
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3. Epidemiology of Prostate Cancer in the Republic of Kazakhstan

Author

Meruert Gazaliyeva, Oxana Shatkovskaya, Zhanar Zamanbekova, Yuliya Semenova, Tasbolat Adylkhanov, Dilyara Kaidarova, Marzhan Dauletyarova, Dariga S. Smailova, Lyudmila Pivina, Kuralay Amrenova, Erlan Ospanov, T Belikhina, and Ardak Omarbekov

Subjects
medicine.medical_specialty, Prostate Diseases, Population, Prevalence, Prostate cancer, Screening program, Prostate, Epidemiology, medicine, Mortality, education, education.field_of_study, business.industry, Incidence (epidemiology), lcsh:Public aspects of medicine, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, medicine.disease, Kazakhstan, Prostate-specific antigen, medicine.anatomical_structure, Original Article, Morbidity, business, Demography
Abstract

Background: The incidence and mortality from prostate cancer in most native Asian populations remain low although a gradual increase is observed over the last years. Methods: The statistical analysis of official data on prostate cancer mortality and morbidity was performed for the whole country and for Pavlodar Region. Results: The increase in the incidence of prostate cancer among the population of Kazakhstan is observed, which may be attributed to the introduction of screening program based on serum PSA. Still, the crude incidence rates in Kazakhstan are below world indices. Over the last few years, the decreasing prostate cancer mortality is observed that might be influenced by early diagnosis. The age-standardized incidence rates show that the majority of prostate cancer cases occur in advanced ages (70 years and older). Conclusion: More research is needed to determine the risk factors for prostate cancer, as well as ethnic and geographical trends for the population of Kazakhstan

Published
2019

4. BRCA1 and TP53 Gene-Mutations: Family Predisposition and Radioecological Risk of Developing Breast Cancer

Author

Bakytbek, Apsalikov, Zukhra, Manambaeva, Erlan, Ospanov, Meruyert, Massabayeva, Kuantkan, Zhabagin, Zhanar, Zhagiparova, Vladymir, Maximov, Elena, Voropaeva, Kazbek, Apsalikov, Tatiana, Belikhina, Ramil, Abdrahmanov, Elena, Cherepkova, Sayat, Tanatarov, Adilzhan, Massadykov, and Naylia, Urazalina

Subjects
Adult, Risk, Polymorphism, Genetic, Genotype, BRCA1 Protein, Breast Neoplasms, Middle Aged, Kazakhstan, Mutation, Humans, Female, Genetic Predisposition to Disease, Tumor Suppressor Protein p53, Aged
Abstract

Frequencies of polymorphisms of genes BRCA1 and TP53 in breast cancer (BC) patients with a BC family history and radiation history were assessed and compared in the Semey region of Kazakhstan. The study included 60 women directly irradiated by the activities of the Semipalatinsk test site with a calculated effective equivalent dose of 500 mSv and their first generation descendants (group BC+Her+Exp); 65 women with family BC and absence of radiological history - the effective equivalent dose due to anthropogenic sources not exceeding 50 mSv (group BC+Her-Exp). The comparison group consisted of 65 women patients with breast cancer without family and radiological history (BC-Her-Exp). The control group comprised 60 women without breast cancer and without family and radiological history (nonBC). We carried out the genotyping of the polymorphisms c.2311TC, c.4308TC and 5382insC of the BRCA1 gene and rs1042522 of the TP53 gene. The frequency of the polymorphism c.2311TC was significantly higher in patients of the group BC+Her+Exp than in healthy women, and of the polymorphism 5382insC in BC+Her+Exp compared to all other groups. The frequency of the rs1042522 polymorphism of TP53 was significantly higher in all groups of patients with breast cancer compared with the control group. Differences between groups of women with breast cancer were significant only in BC+Her+Exp vs. BC+Her-Exp. Combinations of polymorphisms of the genes BRCA1 and TP53 predominated in women with a family and radiological history.

Published
2016

5. BRCA1 and TP53 Gene-Mutations: Family Predisposition and Radioecological Risk of Developing Breast Cancer

Author

Bakytbek Apsalikov, Zukhra Manambaeva, Erlan Ospanov, Meruyert Massabayeva, Kuantkan Zhabagin, Zhanar Zhagiparova, Vladymir Maximov, Elena Voropaeva, Kazbek Apsalikov, Tatiana Belikhina, Ramil Abdrahmanov, and Elena Cherepkova, Sayat Tanatarov, Adilzhan Massa

Subjects
education, health care economics and organizations, humanities, Breast cancer, TP53, BRCA1, polymorphism, radiation factor, the Semipalatinsk test site
Abstract

Asian Pacific Journal of Cancer Prevention, 17, 8

Published
2016
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