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19 results on '"Erkoreka, Leire"'

4. Multilocus Genetic Profile Reflecting Low Dopaminergic Signaling Is Directly Associated with Obesity and Cardiometabolic Disorders Due to Antipsychotic Treatment

Author

Arrue, Aurora, primary, Olivas, Olga, additional, Erkoreka, Leire, additional, Alvarez, Francisco Jose, additional, Arnaiz, Ainara, additional, Varela, Noemi, additional, Bilbao, Ainhoa, additional, Rodríguez, Jose-Julio, additional, Moreno-Calle, María Teresa, additional, Gordo, Estibaliz, additional, Marín, Elena, additional, Garcia-Cano, Javier, additional, Saez, Estela, additional, Gonzalez-Torres, Miguel Ángel, additional, Zumárraga, Mercedes, additional, and Basterreche, Nieves, additional

Published
2023
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8. Genetics of adult attachment: An updated review of the literature

Author

Erkoreka, Leire, primary, Zumarraga, Mercedes, additional, Arrue, Aurora, additional, Zamalloa, M Isabel, additional, Arnaiz, Ainara, additional, Olivas, Olga, additional, Moreno-Calle, Teresa, additional, Saez, Estela, additional, Garcia, Jon, additional, Marin, Elena, additional, Varela, Noemi, additional, Gonzalez-Pinto, Ana, additional, and Basterreche, Nieves, additional

Published
2021
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11. Attachment anxiety as mediator of the relationship between childhood trauma and personality dysfunction in borderline personality disorder.

Author

Erkoreka, Leire, Zamalloa, Iker, Rodriguez, Santiago, Muñoz, Pedro, Mendizabal, Imanol, Zamalloa, M. Isabel, Arrue, Aurora, Zumarraga, Mercedes, and Gonzalez‐Torres, Miguel Angel

Subjects
*ADVERSE childhood experiences, *PERSONALITY, *PSYCHOLOGICAL abuse, *BORDERLINE personality disorder, *CHILD abuse, *EMOTIONAL trauma, *INTERVIEWING, *ATTACHMENT behavior, *BEHAVIOR disorders, *QUESTIONNAIRES, *DESCRIPTIVE statistics, *ANXIETY, *DATA analysis software, *SOCIAL disabilities
Abstract

Insecure attachment has been described as mediating the relationship between childhood trauma and dysfunctional personality traits in different mental disorders. Despite the role insecure attachment and childhood trauma have independently demonstrated to play as determinants of borderline personality disorder, less is known about the mediating mechanisms explaining these associations. For the first time, we assessed adult attachment, childhood trauma and dimensional personality pathology in a sample of outpatients with borderline personality disorder and tested whether the association between childhood trauma and personality dysfunction was at least partially attributable to insecure attachment. The results showed that attachment anxiety fully mediated the relationship between specific types of trauma (emotional abuse and physical neglect) and emotional dysregulation. Further, emotional abuse was both directly associated with dissocial behaviour and indirectly via attachment anxiety (partial mediation). Emotional abuse has been described as an essential environmental factor for the development of borderline personality disorder and emotional dysregulation, on its part, as the core feature of the condition. Our results indicate that attachment anxiety explains the link between these central aspects of borderline personality disorder. Our findings are consistent with previous research and current etiological understanding of the condition and provide support for recommending a careful assessment of childhood traumatic experiences and adult attachment style to gain a more comprehensive insight into the symptoms and its heterogeneity. As a secondary aim, we assessed the effect parental mental illness may have in these mediation models, but no significant influence on childhood trauma, attachment or personality was found. [ABSTRACT FROM AUTHOR]

Published
2022
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13. Influence of 5-HTT, COMT, and BDNFfunctional polymorphisms and their interaction with parental bonding in attachment anxiety, among adults with personality disorders

Author

Erkoreka, Leire, Zamalloa, Iker, Muñoz, Pedro, Rodriguez, Santiago, Arrue, Aurora, and Gonzalez-Torres, Miguel Angel

Abstract

Attachment is the tendency of human beings to create strong affective bonds towards specific figures, and has been described as a general vulnerability factor to diverse forms of psychopathology. Although attachment research has not tended to emphasize genetic contribution, heritability is estimated at 36–45 %. We explored the association between 5-HTTLPR, COMTVal158Met and BDNFVal66Met functional polymorphisms with attachment dimensions, as well as the gene-environment interaction, considering the perceived parental rearing styles, with both a vulnerability and a differential susceptibility approach.

Published
2025
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16. COMT haplotypes, catecholamine metabolites in plasma and clinical response in schizophrenic and bipolar patients

Author

Zumárraga, Mercedes, primary, Arrúe, Aurora, additional, Basterreche, Nieves, additional, Macías, Isabel, additional, Catalán, Ana, additional, Madrazo, Arantza, additional, Bustamante, Sonia, additional, Zamalloa, María I, additional, Erkoreka, Leire, additional, Gordo, Estibaliz, additional, Arnaiz, Ainara, additional, Olivas, Olga, additional, Arroita, Ariane, additional, Marín, Elena, additional, and González-Torres, Miguel A, additional

Published
2016
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17. COMTHaplotypes, Catecholamine Metabolites in Plasma and Clinical Response in Schizophrenic and Bipolar Patients

Author

Zumárraga, Mercedes, Arrúe, Aurora, Basterreche, Nieves, Macías, Isabel, Catalán, Ana, Madrazo, Arantza, Bustamante, Sonia, Zamalloa, María I, Erkoreka, Leire, Gordo, Estibaliz, Arnaiz, Ainara, Olivas, Olga, Arroita, Ariane, Marín, Elena, and González-Torres, Miguel A

Abstract

Aim:We examined the association of COMT haplotypes and plasma metabolites of catecholamines in relation to the clinical response to antipsychotics in schizophrenic and bipolar patients. Patients & methods:We studied 165 patients before and after four weeks of treatment, and 163 healthy controls. We assessed four COMT haplotypes and the plasma concentrations of HVA, DOPAC and MHPG. Results:Bipolar patients: haplotypes are associated with age at onset and clinical evolution. In schizophrenic patients, an haplotype previously associated with increased risk, is related to better response of negative symptoms. Conclusion:Haplotypes would be good indicators of the clinical status and the treatment response in bipolar and schizophrenic patients. Larger studies are required to elucidate the clinical usefulness of these findings.

Published
2016
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18. Manía y cáncer de páncreas.

Author

Basterreche, Nieves, Arrúe, Aurora, Arnaiz, Ainara, Erkoreka, Leire, Peralta, David, and Zumárraga, Mercedes

Subjects
*MANIA, *PANCREATIC cancer, *CANCER & psychology
Published
2017

19. Mania preceding pancreatic cancer.

Author

Basterreche N, Arrúe A, Arnaiz A, Erkoreka L, Peralta D, and Zumárraga M

Subjects
Aged, Humans, Male, Time Factors, Bipolar Disorder complications, Pancreatic Neoplasms complications
Published
2017

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