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31 results on '"Erkkola, Risto U."'

5. Uterine and umbilical flow velocity waveforms in normotensive and hypertensive subjects during the angiotensin II sensitivity test

Author

Erkkola, Risto U. and Pirhonen, Jouko P.

Subjects
Angiotensin, Doppler ultrasonography, Hypertension in pregnancy -- Diagnosis, Uterine circulation, Health
Abstract

The systemic and uterine circulatory effects of angiotensin II infusion in five normotensive and 10 hypertensive subjects at the end of the third trimester of gestation were studied. Color Doppler ultrasonography was used for investigating the systolic/diastolic ratios on flow velocity waveforms in the uterine and umbilical arteries. A significant increase was observed in the systolic/diastolic ratio in the uterine artery in both groups. In normotensive subjects a differential effect of angiotensin II on the systemic diastolic blood pressure and on the systolic/diastolic ratio was observed; the uterine circulation had a slower response and a faster recovery than the maternal diastolic blood pressure. In hypertensive subjects this relative refractoriness to angiotensin II was less marked; the increase in uterine vascular resistance was faster and the recovery slower than in the normotensive group. No changes in the systolic/diastolic ratio in the umbilical artery were observed in either group. These results indicate that the uterine circulation of normotensive subjects is remarkably more refractory to angiotensin II than the circulation of hypertensive subjects. (Am J Obstet Gynecol 1992;166:910-6.)

Published
1992

18. Reply

Author

Mäkinen, Juha I., primary, Erkkola, Risto U., additional, and Laippala, Pekka J., additional

Published
1990
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20. The expression of cyclooxygenase-1 and -2 in proliferative endometrium and endometrial adenocarcinoma.

Author

Uotila, Pekka J., Erkkola, Risto U., and Klemi, Pekka J.

Subjects
CYCLOOXYGENASE 2, ADENOCARCINOMA, NITRIC oxide, EPITHELIUM, ENDOMETRIUM, GENE expression
Abstract

BACKGROUND. The activity of cyclooxygenase-2 (COX-2) is increased in inflammation and in several cancer types. We investigated the expression of COX-2, cyclooxygenase-1 (COX-1), nitric oxide synthase-2 (NOS-2) and nitric oxide synthase-3 (NOS-3) in normal proliferative and secretory human endometrium, and in endometrial adenocarcinoma. METHODS. Human endometrium was collected at hysterectomy. Seven samples were in proliferative and 11 samples in secretory stage. Twelve specimens from endometrial carcinoma were collected, as well. Immunohistochemistry was used to investigate the expression of COX-1, COX-2, NOS-2 and NOS-3. RESULTS. COX-2 immunostaining was detected in most specimens of normal proliferative glandular epithelium (86%) and of endometrial carcinomas (92%). COX-2 staining was often detected in cancer cells on the border areas of the tumour and on the areas of invasive growth. Staining for COX-2 was seen in proliferative glands usually only in the basal layer of the endometrium. NOS-2 was usually absent or negligible in proliferative endometrial glands and also in the cancer cells of endometrial adenocarcinomas. No staining for either COX-2 or NOS-2 was seen in specimens of secretory glandular epithelium. The expression of the constitutive COX-1 and NOS-3 was negligible or weak in the glandular epithelium of proliferative and secretory endometrium and in endometrial cancer cells. CONCLUSIONS. The expression of the inducible COX-2 but not of COX-1 is stimulated in the glandular epithelium of proliferative endometrium and in the cancer cells of human endometrial adenocarcinoma, in particular in those in the borders of carcinoma and spreading into lymphatic vessels. [ABSTRACT FROM AUTHOR]

Published
2002
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