Search

Your search keyword '"Erkert, Lena"' showing total 18 results
Start Over Author "Erkert, Lena"
18 results on '"Erkert, Lena"'

2. Alzheimer’s disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis.

Author

Erkert, Lena, Gamez-Belmonte, Reyes, Kabisch, Melanie, Schödel, Lena, Patankar, Jay V., Gonzalez-Acera, Miguel, Mahapatro, Mousumi, Li-Li Bao, Plattner, Christina, Kühl, Anja A., Jie Shen, Serneels, Lutgarde, De Strooper, Bart, Neurath, Markus F., Wirtz, Stefan, and Becker, Christoph

Subjects
BRUSH border membrane, INFLAMMATORY bowel diseases, MOLECULAR biology, MEDICAL sciences, INTESTINAL barrier function, INTESTINAL tumors, INTESTINAL diseases
Published
2024
Full Text
View/download PDF

3. Caspase‐8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice

Author

Tisch, Nathalie, Mogler, Carolin, Stojanovic, Ana, Luck, Robert, Korhonen, Emilia A, Ellerkmann, Alexander, Adler, Heike, Singhal, Mahak, Schermann, Géza, Erkert, Lena, Patankar, Jay V, Karakatsani, Andromachi, Scherr, Anna‐Lena, Fuchs, Yaron, Cerwenka, Adelheid, Wirtz, Stefan, Köhler, Bruno Christian, Augustin, Hellmut G, Becker, Christoph, Schmidt, Thomas, and Ruiz de Almodóvar, Carmen

Published
2022
Full Text
View/download PDF

4. IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling

Author

Chiriac, Mircea Teodor, primary, Hracsko, Zsuzsanna, additional, Günther, Claudia, additional, Gonzalez-Acera, Miguel, additional, Atreya, Raja, additional, Stolzer, Iris, additional, Wittner, Leonie, additional, Dressel, Anja, additional, Schickedanz, Laura, additional, Gamez-Belmonte, Reyes, additional, Erkert, Lena, additional, Hundorfean, Gheorghe, additional, Zundler, Sebastian, additional, Rath, Timo, additional, Vetrano, Stefania, additional, Danese, Silvio, additional, Sturm, Gregor, additional, Trajanoski, Zlatko, additional, Kühl, Anja A, additional, Siegmund, Britta, additional, Hartmann, Arndt, additional, Wirtz, Stefan, additional, Siebler, Jürgen, additional, Finotto, Susetta, additional, Becker, Christoph, additional, and Neurath, Markus F, additional

Published
2023
Full Text
View/download PDF

5. Analysis of the interferon-γ-induced secretome of intestinal endothelial cells: putative impact on epithelial barrier dysfunction in IBD

Author

Naschberger, Elisabeth, primary, Flierl, Christian, additional, Huang, Jinghao, additional, Erkert, Lena, additional, Gamez-Belmonte, Reyes, additional, Gonzalez-Acera, Miguel, additional, Bober, Magdalena, additional, Mehnert, Martin, additional, Becker, Christoph, additional, Schellerer, Vera S., additional, Britzen-Laurent, Nathalie, additional, and Stürzl, Michael, additional

Published
2023
Full Text
View/download PDF

7. IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling.

Author

Chiriac, Mircea Teodor, Hracsko, Zsuzsanna, Günther, Claudia, Gonzalez-Acera, Miguel, Atreya, Raja, Stolzer, Iris, Wittner, Leonie, Dressel, Anja, Schickedanz, Laura, Gamez-Belmonte, Reyes, Erkert, Lena, Hundorfean, Gheorghe, Zundler, Sebastian, Rath, Timo, Vetrano, Stefania, Danese, Silvio, Sturm, Gregor, Zlatko Trajanoski, Kühl, Anja A., and Siegmund, Britta

Subjects
KNOCKOUT mice, COLITIS, BIOCHEMISTRY, MEDICAL sciences, CELL adhesion molecules, INFLAMMATORY bowel diseases, ISCHEMIC colitis
Published
2024
Full Text
View/download PDF

8. Epithelial presenilin-1 drives colorectal tumour growth by controlling EGFR-COX2 signalling

Author

Gamez-Belmonte, Reyes, primary, Mahapatro, Mousumi, additional, Erkert, Lena, additional, Gonzalez-Acera, Miguel, additional, Naschberger, Elisabeth, additional, Yu, Yuqiang, additional, Tena-Garitaonaindia, Mireia, additional, Patankar, Jay V, additional, Wagner, Yara, additional, Podstawa, Eva, additional, Schödel, Lena, additional, Bubeck, Marvin, additional, Neurath, Markus F, additional, Stürzl, Michael, additional, and Becker, Christoph, additional

Published
2022
Full Text
View/download PDF

9. Epithelial presenilin-1 drives colorectal tumour growth by controlling EGFR-COX2 signalling.

Author

Gamez-Belmonte, Reyes, Mahapatro, Mousumi, Erkert, Lena, Gonzalez-Acera, Miguel, Naschberger, Elisabeth, Yuqiang Yu, Tena-Garitaonaindia, Mireia, Patankar, Jay V., Wagner, Yara, Podstawa, Eva, Schödel, Lena, Bubeck, Marvin, Neurath, Markus F., Stürzl, Michael, and Becker, Christoph

Subjects
INTESTINAL tumors, MOLECULAR biology, EPIDERMAL growth factor receptors, TUMORS
Published
2023
Full Text
View/download PDF

10. Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation

Author

Martínez-Sánchez, Luz del Carmen, primary, Ngo, Phuong Anh, additional, Pradhan, Rashmita, additional, Becker, Lukas-Sebastian, additional, Boehringer, David, additional, Soteriou, Despina, additional, Kubankova, Marketa, additional, Schweitzer, Christine, additional, Koch, Tatyana, additional, Thonn, Veronika, additional, Erkert, Lena, additional, Stolzer, Iris, additional, Günther, Claudia, additional, Becker, Christoph, additional, Weigmann, Benno, additional, Klewer, Monika, additional, Daniel, Christoph, additional, Amann, Kerstin, additional, Tenzer, Stefan, additional, Atreya, Raja, additional, Bergo, Martin, additional, Brakebusch, Cord, additional, Watson, Alastair J M, additional, Guck, Jochen, additional, Fabry, Ben, additional, Atreya, Imke, additional, Neurath, Markus F, additional, and López-Posadas, Rocío, additional

Published
2022
Full Text
View/download PDF

11. Epithelial RAC1- dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation.

Author

Sánchez, Luz del Carmen Martínez, Ngo, Phuong Anh, Pradhan, Rashmita, Becker, Lukas- Sebastian, Boehringer, David, Soteriou, Despina, Kubankova, Marketa, Schweitzer, Christine, Koch, Tatyana, Thonn, Veronika, Erkert, Lena, Stolzer, Iris, Günther, Claudia, Becker, Christoph, Weigmann, Benno, Klewer, Monika, Daniel, Christoph, Amann, Kerstin, Tenzer, Stefan, and Atreya, Raja

Subjects
CELLULAR mechanics, INTESTINES, CYTOSKELETON, INFLAMMATORY bowel diseases, CROHN'S disease
Published
2023
Full Text
View/download PDF

12. Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation

Author

Martínez-Sánchez, Luz del Carmen, Ngo, Phuong Anh, Pradhan, Rashmita, Becker, Lukas-Sebastian, Boehringer, David, Soteriou, Despina, Kubankova, Marketa, Schweitzer, Christine, Koch, Tatyana, Thonn, Veronika, Erkert, Lena, Stolzer, Iris, Gu¨nther, Claudia, Becker, Christoph, Weigmann, Benno, Klewer, Monika, Daniel, Christoph, Amann, Kerstin, Tenzer, Stefan, Atreya, Raja, Bergo, Martin, Brakebusch, Cord, Watson, Alastair J M, Guck, Jochen, Fabry, Ben, Atreya, Imke, Neurath, Markus F, and López-Posadas, Rocío

Abstract

ObjectiveIncreased apoptotic shedding has been linked to intestinal barrier dysfunction and development of inflammatory bowel diseases (IBD). In contrast, physiological cell shedding allows the renewal of the epithelial monolayer without compromising the barrier function. Here, we investigated the role of live cell extrusion in epithelial barrier alterations in IBD.DesignTaking advantage of conditional GGTase and RAC1 knockout mice in intestinal epithelial cells (Pggt1biΔIECand Rac1iΔIECmice), intravital microscopy, immunostaining, mechanobiology, organoid techniques and RNA sequencing, we analysed cell shedding alterations within the intestinal epithelium. Moreover, we examined human gut tissue and intestinal organoids from patients with IBD for cell shedding alterations and RAC1 function.ResultsEpithelial Pggt1bdeletion led to cytoskeleton rearrangement and tight junction redistribution, causing cell overcrowding due to arresting of cell shedding that finally resulted in epithelial leakage and spontaneous mucosal inflammation in the small and to a lesser extent in the large intestine. Both in vivo and in vitro studies (knockout mice, organoids) identified RAC1 as a GGTase target critically involved in prenylation-dependent cytoskeleton dynamics, cell mechanics and epithelial cell shedding. Moreover, inflamed areas of gut tissue from patients with IBD exhibited funnel-like structures, signs of arrested cell shedding and impaired RAC1 function. RAC1 inhibition in human intestinal organoids caused actin alterations compatible with arresting of cell shedding.ConclusionImpaired epithelial RAC1 function causes cell overcrowding and epithelial leakage thus inducing chronic intestinal inflammation. Epithelial RAC1 emerges as key regulator of cytoskeletal dynamics, cell mechanics and intestinal cell shedding. Modulation of RAC1 might be exploited for restoration of epithelial integrity in the gut of patients with IBD.

Published
2023
Full Text
View/download PDF

13. Severe Acute Respiratory Syndrome Coronavirus 2 Attachment Receptor Angiotensin-Converting Enzyme 2 Is Decreased in Crohn’s Disease and Regulated By Microbial and Inflammatory Signaling

Author

Patankar, Jay Vasant, primary, Chiriac, Mircea Teodor, additional, Lehmann, Malte, additional, Kühl, Anja A., additional, Atreya, Raja, additional, Becker, Christoph, additional, Gonzalez-Acera, Miguel, additional, Schmitt, Heike, additional, Gamez-Belmonte, Reyes, additional, Mahapatro, Mousumi, additional, Diemand, Leonard, additional, Hartmann, Leonie, additional, Mascia, Fabrizio, additional, Hracsko, Zsuzsanna, additional, Thonn, Veronika, additional, Schödel, Lena, additional, Zielinska, Marta, additional, Yu, Yuqiang, additional, Erkert, Lena, additional, Li, Wei, additional, Zeitler, Melanie, additional, Ruder, Barbara, additional, Ganzleben, Ingo, additional, Günther, Claudia, additional, Voehringer, David, additional, Zundler, Sebastian, additional, Neurath, Markus F., additional, and Siegmund, Britta, additional

Published
2021
Full Text
View/download PDF

17. An IKK/NF-κB Activation/p53 Deletion Sequence Drives Liver Carcinogenesis and Tumor Differentiation

Author

Svinarenko, Michael, primary, Katz, Sarah-Fee, additional, Tharehalli, Umesh, additional, Mulaw, Medhanie A., additional, Maier, Harald J., additional, Sunami, Yoshiaki, additional, Fischer, Sarah K., additional, Chen, Yuexin, additional, Heurich, Sabine, additional, Erkert, Lena, additional, Tannapfel, Andrea, additional, Wirth, Thomas, additional, Schirmbeck, Reinhold, additional, Seufferlein, Thomas, additional, and Lechel, André, additional

Published
2019
Full Text
View/download PDF

18. An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learning

Author

Sallis, Benjamin F., primary, Erkert, Lena, additional, Moñino-Romero, Sherezade, additional, Acar, Utkucan, additional, Wu, Rina, additional, Konnikova, Liza, additional, Lexmond, Willem S., additional, Hamilton, Matthew J., additional, Dunn, W. Augustine, additional, Szepfalusi, Zsolt, additional, Vanderhoof, Jon A., additional, Snapper, Scott B., additional, Turner, Jerrold R., additional, Goldsmith, Jeffrey D., additional, Spencer, Lisa A., additional, Nurko, Samuel, additional, and Fiebiger, Edda, additional

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results