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2. Comprehensive geriatric assessment and drug burden in elderly chronic kidney disease patients

Author

Erken Neziha and Erken Ertugrul

Subjects
chronic kidney disease, geriatric syndromes, frailty, anticholinergic burden, polypharmacy, drug interaction, Biochemistry, QD415-436
Abstract

Chronic kidney disease (CKD) is a condition characterized by atherosclerosis, cognitive impairment, physical limitations, biochemical abnormalities, and vascular aging. The proportion of those with a diagnosis of CKD in the older is increasing. With comprehensive geriatric assessment, it could be possible to detect the disorders that are related to biological aging. The aim is to evaluate geriatric syndromes like frailty, cognitive dysfunction, malnutrition, and polypharmacy in an aged population with pre-dialytic CKD (stages 3a–5), and to investigate possible relations with biochemical features and anticholinergic drug burden (ADB).

Published
2023
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4. Effect of Treatment Cost and Methods on Survival in Hepatocellular Carcinoma.

Author

Erken, Neziha Ulusoylar, Araz, Filiz, Erken, Ertugrul, and Ozer, Birol

Subjects
TREATMENT effectiveness, LIVER cancer, PROGNOSIS, OVERALL survival, TUMOR classification, HEPATOCELLULAR carcinoma
Abstract

Copyright of Kafkas Journal of Medical Sciences / Kafkas Tıp Bilimleri Dergisi is the property of Kafkas Journal of Medical Sciences, Kafkas Tip Bilimleri Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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6. Acute renal infarction in Turkey: a review of 121 cases

Author

Eren, Necmi, Gungor, Ozkan, Kocyigit, Ismail, Guzel, Fatma Betul, Erken, Ertugrul, Altunoren, Orcun, Tatar, Erhan, Eroglu, Eray, Senel, Egemen, Kaya, Bulent, Paydaş, Saime, Onan, Bilen, Sahin, Safak, Yilmaz, Mumtaz, Ulu, Sena, Gursu, Meltem, Ozkok, Abdullah, Yildiz, Abdulmecit, Kurultak, Ilhan, Ucar, Ali Rıza, Tanrisev, Mehmet, Turgutalp, Kenan, Turan, Mehmet Nuri, Huzmeli, Can, Soypacaci, Zeki, Akdam, Hakan, Huddam, Bulent, Adibelli, Zelal, Kara, Ekrem, Inci, Ayca, Turkmen, Ercan, Tekce, Hikmet, Dogukan, Ayhan, and Turkmen, Aydin

Published
2018
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18. The relationship between hepatic fibrosis and arterial stiffness in hemodialysis patients.

Author

Guzel, Fatma Betul, Ozturk, Ilyas, Gisi, Kadir, Ispiroglu, Murat, Akkus, Gulsum, Erken, Ertugrul, Altunoren, Orcun, and Gungor, Ozkan

Subjects
HEPATIC fibrosis, ARTERIAL diseases, HEMODIALYSIS patients, HEMODIALYSIS, POLYCYSTIC kidney disease, NON-alcoholic fatty liver disease
Abstract

Introduction: The main cause of death in hemodialysis patients is cardiovascular diseases. Increased arterial stiffness is a predictor of cardiovascular events for hemodialysis patients. Among the nondialysis patient population, arterial stiffness increases in those with hepatic fibrosis and nonalcoholic fatty liver disease. This study aims to examine the relationship between hepatic fibrosis and arterial stiffness in hemodialysis patients for the first time in the literature. Material and method: The study includes chronic hemodialysis patients over 18 years of age who had been treated for hemodialysis for at least 6 months. Patients with chronic liver disease, chronic viral hepatitis (HBV and HCV), alcohol use, or liver disease accompanied by polycystic kidney disease and active infection were excluded. Hepatic fibrosis scores were measured using the FibroScan device. Single‐cuff Mobil‐o‐Graph was used for measurement of arterial stiffness. Results: Fifty‐nine patients were enrolled; 54.2% of the patients were male, and the mean age was 53.9 ± 12.9 years. Thirty‐nine percent of the patients had diabetes. Average pulse wave velocity (PWV) value of the patients was 8.3 ± 1.6 m/s, and it had positive correlation with age, CAP score, fibrosis score, and body mass index and showed negative correlation to albumin. It was seen that the patients with a PWV value ≥ 10 m/s have significantly higher CAP score compared with the patients with a PWV < 10 m/s. When the factors predicting PWV were examined in the regression analysis, age and systolic blood pressure were found to be determinants. Conclusion: Increased hepatic fibrosis in hemodialysis patients is associated with increased arterial stiffness, but this relationship is not independent. [ABSTRACT FROM AUTHOR]

Published
2022
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21. Can vasohibin‐1, an endothelium‐derived angiogenesis inhibitor, be a marker of endothelial dysfunction in hemodialysis patients?

Author

Altunoren, Orcun, primary, Kerkutluoglu, Murat, additional, Sarısık, Feyza Nur, additional, Akkus, Gulsum, additional, Seyithanoglu, Muhammed, additional, Doganer, Adem, additional, Tutuncu Sezal, Didem, additional, Cagrı Aykan, Ahmet, additional, Eren, Necmi, additional, Erken, Ertugrul, additional, and Gungor, Ozkan, additional

Published
2020
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22. Hematological Parameters and Clinical Features in Patients with Advanced Chronic Kidney Disease

Author

Erken, Ertugrul, Ulgen, Cansu, Sarisik, Feyza Nur, Erken, Neziha, Gungor, Ozkan, Altunoren, Orcun, Erken, Ertugrul, Ulgen, Cansu, Sarisik, Feyza Nur, Erken, Neziha, Gungor, Ozkan, and Altunoren, Orcun

Abstract

[Background] Hematological parameters like red cell distribution width (RDW) and mean platelet volume (MPV) were reported to be associated with inflammation, atherosclerosis, and chronic kidney disease (CKD) progression. In this study, we evaluated RDW and MPV along with clinical features in patients with advanced CKD. We also aimed to detect clues for causative relations concerning these parameters, renal function and comorbidities. [Methods] Stage 3-5 CKD patients (627 total) were included (mean age 63.1 years, 48.3% male). Patients with malignancies, cirrhosis, infections, severe anemia, and systemic inflammation were excluded. Patients were evaluated for clinical features and grouped for comparison using median RDW and MPV. Linear regression models were generated to predict potential influences on RDW and MPV. [Results] Mean estimated glomerular filtration rate (eGFR) was 27.3 mL/min/1.73m2. Mean Charlson Comorbidity Index (CCI) score was 5.83 ± 2.06. Patients with high RDW (n = 303) were older with higher CRP and CCI, they also had lower eGFR, hemoglobin, and albumin (P < 0.001 for all). Patients with low MPV (n = 311) had lower eGFR, and platelet counts (P = 0.015 and 0.017). eGFR was negatively correlated with RDW after adjusting for age, gender and comorbidities. In a further adjusted model RDW was associated with CRP, CCI, hemoglobin and albumin (P < 0.05 for all), not with eGFR. MPV was positively correlated with eGFR in our adjusted, and fully adjusted regression models (P = 0.003). [Conclusion] In this study, we found that high RDW is associated with comorbidity burden, anemia, and inflammatory status in patients with advanced CKD. Meanwhile, low MPV seems to be associated with worse renal function.

Published
2020

29. Does neutrophyl to lymphocyte ratio really predict chronic kidney disease progression?

Author

Altunoren, Orcun, primary, Akkus, Gulsum, additional, Sezal, Didem Tutuncu, additional, Ciftcioglu, Muhammed, additional, Guzel, Fatma Betul, additional, Isiktas, Songul, additional, Torun, Gul Inci, additional, Uyan, Merve, additional, Sokmen, Murat Fatih, additional, Sevim, Hatıce Ayyildiz, additional, Sarısık, Feyza Nur, additional, Senel, Mahmut Egemen, additional, Erken, Ertugrul, additional, and Gungor, Ozkan, additional

Published
2018
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32. IL-33 and ST2 levels in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events, and survival

Author

Gungor, Ozkan, primary, Unal, Hilmi Umut, additional, Guclu, Aydin, additional, Gezer, Mustafa, additional, Eyileten, Tayfun, additional, Guzel, Fatma Betül, additional, Altunoren, Orcun, additional, Erken, Ertugrul, additional, Oguz, Yusuf, additional, Kocyigit, Ismail, additional, and Yilmaz, Mahmut Ilker, additional

Published
2017
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35. KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR GENOTYPE DISTRIBUTION IN FAMILIAL MEDITERRANEAN FEVER: NO ASSOCIATION WITH DISEASE PHENOTYPE AND RENAL AMYLOIDOSIS

Author

Erken, Ertugrul, Ozturk, Ozlem Goruroglu, Kudas, Ozlem, Tas, Didem Arslan, Demirtas, Ahmet, Kibar, Filiz, Dinkci, Suzan, and Çukurova Üniversitesi

Subjects
[Anahtar Kelime Yok], urologic and male genital diseases
Abstract

52nd Congress of the European-Renal-Association-European-Dialysis-and-Transplant-Assocation -- MAY 28-31, 2015 -- London, ENGLAND WOS: 000361215101452 … European Renal Assoc, European Dialysis & Transplant Assoc

Published
2015

36. Watershed Cerebral Infarction in a Patient with Acute Renal Failure

Author

Ozelsancak, Ruya, Erken, Ertugrul, Giray, Semih, and Alkan, Ozlem

Subjects
Dysarthria, lcsh:R, Watershed Infarction, lcsh:Medicine, Acute Renal Failure
Abstract

Acute renal failure can cause neurologic manifestations such as mood swings, impaired concentration, tremor, stupor, coma, asterixis, dysarthria. Those findings can also be a sign of cerebral infarct. Here, we report a case of watershed cerebral infarction in a 70-year-old female patient with acute renal failure secondary to contrast administration and use of angiotensin converting enzyme inhibitor. Patient was evaluated with magnetic resonance imaging because of dysarthria. Magnetic resonance imaging revealed milimmetric acute ischemic lesion in the frontal and parietal deep white matter region of both cerebral hemisphere which clearly demonstrated watershed cerebral infarction affecting internal border zone. Her renal function returned to normal levels on fifth day of admission (BUN 32 mg/dl, creatinine 1.36 mg/dl) and she was discharged. Dysarthria continued for 20 days.

Published
2015

43. Cardiac disease in familial Mediterranean fever.

Author

Erken, Eren and Erken, Ertugrul

Subjects
FAMILIAL Mediterranean fever, HEART diseases, INFLAMMATION, POLYARTERITIS nodosa, BEHCET'S disease, PHYSIOLOGICAL effects of cytokines, IMMUNOSUPPRESSIVE agents
Abstract

Familial Mediterranean fever (FMF) is an autoinflammatory disease manifested by inflammatory attacks of peritonitis, pleuritis, pericarditis accompanied by fever and arthritis. Mutations of MEFV gene results in pyrin dysfunction, which causes uncontrolled interleukin-1 beta production and triggers the inflammatory attacks. Inflammation persists even during attack-free periods in one-third of the FMF patients. Findings of elevated proinflammatory cytokine patterns during remission as well as inflammatory attacks indicate the continuous subclinical disease activity and inflammation. Chronic inflammation was thought to be related to the cardiovascular risk in FMF patients. Main cardiac manifestations reported in FMF are pericarditis, idiopathic recurrent pericarditis, pericardiac tamponade, coronary heart disease and abnormal cardiovascular reactivity. Cardiac involvement in FMF may often be related to secondary AA amyloidosis. Deposition of amyloid may lead to cardiovascular morbidity and mortality in FMF patients. Associations of several vasculitic disorders such as Immunoglobulin A-associated vasculitis, polyarteritis nodosa and Behcet's disease are common in FMF. Appropriate prophylactic treatment with colchicine is recommended to prevent from cardiovascular risks. For those resistant to colchicine, IL-1 inhibitor agents can be used. Associated vasculitis should be treated with immunosuppressive agents. This review article aims to compile information about cardiac disease in FMF and refer to recent studies on the topic. [ABSTRACT FROM AUTHOR]

Published
2018
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