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HER2 is an important and targetable molecule in breast cancer. In the early stages of breast cancer, a treatment modality called neoadjuvant therapy, which now includes anti-HER2 therapies, is administered before surgery in order to achieve disease regression and make the patient suitable for a more minor operation. In breast cancer, HER2 status may be positive in the initial biopsy specimen and negative in the surgical specimen. HER2 status plays an important role in treatment decisions. In this study, we investigated the factors causing HER2 status to change in early-stage breast cancer. This study has a retrospective design and includes 400 female patients with early-stage breast cancer. The results of the study identified the factors causing HER2 status to change to negative as receipt of neoadjuvant therapy, small tumor size and younger age.

The optimal chemotherapy regimen for concurrent chemoradiation in locally advanced non-small cell lung cancer (NSCLC) remains unclear. Cisplatin-etoposide regimen related toxicity is high, weekly regimens have been investigating. We aimed to compare the efficacy and safety of different concurrent chemotherapy regimens in the context. A total of 225 patients with locally advanced, unresectable stage III NSCLC were included. Patients who were treated with weekly docetaxel-platin (DP), paclitaxel-platin (PP) and standard dose etoposide-platin (EP) chemotherapy regimens were selected and divided into groups for the comparison of toxicity, response rate, progression free survival (PFS), and overall survival (OS) times. There was a statistically significant difference between overall response rate of each treatment groups (DP: 96.1%, PP: 94% and EP: 76.7%, p

Objective: The prognostic value of tumor location in patients with metastatic colorectal cancer (mCRC) was reported by recent analyses in RAS wild-type patients. However, there is no enough specific data regarding prognostic value of primary tumor location in RAS mutated mCRC patients. We aimed to find if there is any relation between tumor prognosis and primary tumor location in patients with RAS mutated mCRC. Method: This retrospective study included 57 patients with mCRC who were diagnosed and treated in our hospital between January 2011 and December 2017. Characteristics features of the patients were obtained from our institution patient medical records. Patients were included to the present study if KRAS or NRAS mutation was detected in tumor tissues.Results: Twenty-nine (50.9%) of patients were female and the median age of all patients was 52 (18-80) years. Forty (70.2%) of 57 patients were defined as left side (LS) and 17 (29.8%) of patients were located in the right side (RS). As first line systemic treatment, twenty-five (43.9%) patients had received oxaliplatin-based chemotherapy while 32 (56.1%) patients had received irinotecan-based chemotherapy. Tumor sidedness did not affect on progression-free survival (PFS) (mPFS, 10.9 months for LS vs 8.1 months for RS, p=0.400) and overall survival (OS) (mOS, 20.9 months for LS vs 20.8 months for RS, p=0.930).The patients who had oxaliplatin based chemotherapy regimens showed better OS rate than irinotecan based regimens (28.7months vs16.3 months, p=0.017, respectively). Conclusion: Our study results support the thought that claims the sidedness of primary CRC in metastatic setting does not have effect on PFS and OS in patients with RAS mutant mCRC. However, our findings also underline the necessity of studies with larger patient populations and subgroup analyzes to evaluate potential prognostic and molecular features to determine the standart approach to this specific subgroup of the disease. Amaç: RAS wild metastatik kolorektak kanser (KRK) tanılı hastalarda tümör lokalizasyonun prognostik önemi hakkında çok sayıda çalışma bildirilmiştir. Ancak RAS mutant hastalar ile ilgili yeterli sayıda çalışma bulunmamaktadır. Bu çalışmada RAS mutant metastatik KRK tanılı hastalarda tümör yerleşim yerinin prognostik önemini belirlemeyi amaçladık. Yöntemler: Bu retrospektif çalışmaya hastanemizde 2011 ve 2017 yılları arasında tanı alan RAS mutant metastatik KRK tanılı 57 hasta dahil edildi. Hasta özellikleri hastane kayıt sistemindeki verilerden elde edildi. KRAS veya NRAS mutasyonu saptanan hastalar dahil edildi. Bulgular: Hastalardan 29 ’u (%50,9) kadın olup ortanca yaş 52 (18-80) idi. Primer tümör, hastaların 40’ında (%70,2) sol kolon ve 17’sinde (%29,8) sağ kolonda yerleşim göstermekteydi. Yirmi beş (%43,9) hasta oxaliplatin temelli ve 32 (%56,1) hasta da irinotekan temelli kemoterapi almıştı. Primer tümör lokalizasyonuna göre progresyonsuz sağkalım (PSK) ve genel sağkalım (GSK) süreleri arasında istatiksel anlamlı fark saptanmadı (PSK sol kolonda 10.9 ay, sağ kolonda 8.1 ay, p=0.400 ve GSK sol kolonda 20.9 ay, sağ kolonda 20.8 ay, p=0.930). Oxaliplatin temelli tedavi alan hastaların irinotekan temelli tedavi alanlara göre GSK ’larının daha iyi olduğu görüldü (28.7 ay,16.3 ay, sırası ile p=0.017). Sonuç: Çalışmamızda metastatik KRK hastalarında primer tümör yerleşim yerine göre guruplar arasında PSK ve GSK açısından fark saptanmadı. Ancak, bulgularımız bu hasta alt gurubu için standart yaklaşımın belirlenmesi için daha büyük hasta popülasyonları ve alt grup analizleri ile potansiyel prognostik ve moleküler özelliklerin değerlendirildiği çalışmalara olan ihtiyacın altını çizmektedir.

A 52 year-old-man with known parotid gland cancer presented with metastasis of foot. The lesion mimicked diabetic foot ulceration. In this report we aimed that; underlie the distant metastasis of parotid gland cancer and consider the possibility of tumor metastasis in lesion resembling diabetic foot ulceration.