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This review provides the engineering strategies, systematic classification and representative applications of MOF-based hydrogels, and future prospects have also been presented in detail.

Although some European countries imposed measures that successfully slowed the transmission of Covid-19 during the first year of the pandemic, others struggled, either because they acted slowly or implemented measures ineffectively. In this paper we consider the European experience with public health measures designed to prevent transmission of COVID-19. Based on literature and country responses described in the COVID-19 Health System Response Monitor from March 2020 to December 2020, we consider some critical aspects of public health policy responses. These include the importance of public health capacity that can scale up surveillance and outbreak control, including effective testing and contract tracing, of clear messaging based on an understanding of human behaviour, policies that address the undesirable consequences of necessary measures, such as support for those isolating or unable to earn, and the ability to implement at pace and scale a major vaccine rollout. We conclude that for countries to be successful at preventing COVID-19 transmission, there is a need for a clear strategy with explicit goals and a whole systems approach to implementation.

The COVID-19 pandemic triggered abrupt challenges for health care providers, requiring them to simultaneously plan for and manage a rise of COVID-19 cases while maintaining essential health services. Since March 2020, the COVID-19 Health System Response Monitor, a joint initiative of the European Observatory on Health Systems and Policies, the WHO Regional Office for Europe, and the European Commission, has documented country responses to COVID-19 using a structured template which includes a section on provision of care. Using the information available on the platform, this paper analyzes how countries planned services for potential surge capacity, designed patient flows ensuring separation between COVID-19 and non-COVID-19 patients, and maintained routine services in both hospital and ambulatory settings. Despite very real differences in the organization of health and care services, there were many similarities in country responses. These include transitioning the management of COVID-19 mild cases from hospitals to outpatient settings, increasing the use of remote consultations, and cancelling or postponing non-urgent services during the height of the first wave. In the immediate future, countries will have to continue balancing care for COVID-19 and non-COVID-19 patients to minimize adverse health outcomes, ideally with supporting guidelines and COVID-19-specific care zones. Looking forward, policymakers will have to consider whether strategies adopted during the COVID-19 pandemic will become permanent features of care provision.

This paper analyses the health policy response to the COVID-19 pandemic in the four Visegrad countries – Czechia, Hungary, Poland, and Slovakia – in spring and summer 2020. The four countries implemented harsh transmission prevention measures at the beginning of the pandemic and managed to effectively avoid the first wave of infections during spring. Likewise, all four relaxed most of these measures during the summer and experienced uncontrolled growth of cases since September 2020. Along the way, there has been an erosion of public support for the government measures. This was mainly due to economic considerations taking precedent but also likely due to diminished trust in the government. All four countries have been overly reliant on their relatively high bed capacity, which they managed to further increase at the cost of elective treatments, but this could not always be supported with sufficient health workforce capacity. Finally, none of the four countries developed effective find, test, trace, isolate and support systems over the summer despite having relaxed most of the transmission protection measures since late spring. This left the countries ill-prepared for the rise in the number of COVID-19 infections they have been experiencing since autumn 2020.

Policy Points We compared the structure of health care systems and the financial effects of the COVID-19 pandemic on health care providers in the United States, England, Germany, and Israel: systems incorporating both public and private insurers and providers. The negative financial effects on health care providers have been more severe in the United States than elsewhere, owing to the prevalence of activity-based payment systems, limited direct governmental control over available provider capacity, and the structure of governmental financial relief. In a pandemic, activity-based payment reverses the conventional financial positions of payers and providers and may prevent providers from prioritizing public health because of the desire to avoid revenue loss caused by declines in patient visits.

The stiffness and tensile strength of biopolymers (e.g., polylactic acid (PLA)) are less than desirable for load-bearing applications in their neat form. The use of natural fibers as reinforcements...

Feedstock variability is a significant barrier to the scale-up and commercialization of lignocellulosic biofuel technologies. Variability in feedstock characteristics and behavior creates numerous ...

The importance of size reduction to the commercial deployment of biomass utilization technologies cannot be overemphasized. Size reduction is necessary to create good flowing, easily digestible lig...

Epoxy is a widely used polymer because of its ease of processing, high adhesiveness, and high chemical resistance. Epoxy-based composites are commonly used in aerospace, automotive, and marine applications. The epoxy type, function, curing agent, and curing process are discussed in this chapter. Epoxy is used as either a filler or polymer matrix in composite applications. As a filler, the epoxy modification on the fiber is discussed. As a polymer matrix, the epoxy is reinforced by natural and synthetic fibers. The manufacturing process and the fabricated epoxy-based composites’ performance (e.g., mechanical and thermal properties) are investigated. The advantages and disadvantages of epoxy’s function are discussed and summarized. Epoxy modification is an effective approach to improve the composites’ performance.

At the onset of the COVID-19 pandemic, health care providers had to abruptly change their way of providing care in order to simultaneously plan for and manage a rise of COVID-19 cases while maintaining essential health services. Even the most well-resourced health systems faced pressures from new challenges brought on by COVID-19, and every country had to make difficult choices about how to maintain access to essential care while treating a novel communicable disease. Using the information available on the HSRM platform from the early phases of the pandemic, we analyze how countries planned services for potential surge capacity, designed patient flows ensuring separation between COVID-19 and non-COVID-19 patients, and maintained routine services in both hospital and outpatient settings. Many country responses displayed striking similarities despite very real differences in the organization of health and care services. These include transitioning the management of COVID-19 mild cases from hospitals to outpatient settings, increasing the use of remote consultations, and cancelling or postponing non-urgent services during the height of the first wave. In the immediate future, countries will have to continue balancing care for COVID-19 and non-COVID-19 patients to minimize adverse health outcomes, ideally with supporting guidelines and COVID-19-specific care zones. Many countries expect to operate at lower capacity for routinely provided care, which will impact patient access and waiting times. Looking forward, policymakers will have to consider whether strategies adopted during the COVID-19 pandemic will become permanent features of care provision.

The COVID-19 pandemic has dramatically impacted primary health care (PHC) across Europe. Since March 2020, the COVID-19 Health System Response Monitor (HSRM) has documented country-level responses using a structured template distributed to country experts. We extracted all PHC-relevant data from the HSRM and iteratively developed an analysis framework examining the models of PHC delivery employed by PHC providers in response to the pandemic, as well as the government enablers supporting these models. Despite the heterogenous PHC structures and capacities across European countries, we identified three prevalent models of PHC delivery employed: (1) multi-disciplinary primary care teams coordinating with public health to deliver the emergency response and essential services; (2) PHC providers defining and identifying vulnerable populations for medical and social outreach; and (3) PHC providers employing digital solutions for remote triage, consultation, monitoring and prescriptions to avoid unnecessary contact. These were supported by government enablers such as increasing workforce numbers, managing demand through public-facing risk communications, and prioritising pandemic response efforts linked to vulnerable populations and digital solutions. We discuss the importance of PHC systems maintaining and building on these models of PHC delivery to strengthen preparedness for future outbreaks and better respond to the contemporary health challenges.

The economic viability of the biofuel industry could be improved by adding a high-value revenue stream for biomass supply chains: bioderived composites for the rapidly expanding large-scale additive manufacturing industry (i.e., 3D printing). Using fibrillated fibers derived from biomass (e.g.

In 2017, the Estonian government addressed the longstanding challenge of financial sustainability of the health system by expanding its revenue base. As a relatively low-spending country on health, Estonia relies predominantly on payroll contributions from the working population, which exposes the system to economic shocks and population ageing. In an effort to reduce these vulnerabilities, Estonia will gradually introduce a government transfer on behalf of pensioners, although long-term sustainability of the health system could still prove challenging as the overall health spending as a percentage of GDP is not expected to substantially increase. Estonia has rolled out the reform according to plan, but it has led to debate about the need to achieve universal population coverage (currently at about 95%). Moreover, the Estonian experience also holds important lessons for other countries looking to reform their health system. For example, policymakers should recognize that reforms require extensive preparation using consistent messaging over a long period of time, also to prevent prioritising short term and popular fixes over structural reforms. Additionally, collaboration between the health and financial ministries throughout the reform increases the buy-in for the reform and likelihood of adoption. Furthermore, health professionals play a significant role in advocacy, and seeking support from this group can smooth the path towards health system reform.

Countries with social health insurance (SHI) systems display some common defining characteristics - pluralism of actors and strong medical associations - that, in dealing with crisis times, may allow for common learnings. This paper analyses health system responses during the COVID-19 pandemic in eight countries representative of SHI systems in Europe (Austria, Belgium, France, Germany, Luxembourg, the Netherlands, Slovenia and Switzerland). Data collection and analysis builds on the methodology and content in the COVID-19 Health System Response Monitor (HSRM) up to November 2020. We find that SHI funds were, in general, neither foreseen as major stakeholders in crisis management, nor were they represented in crisis management teams. Further, responsibilities in some countries shifted from SHI funds to federal governments. The overall organisation and governance of SHI systems shaped how countries responded to the challenges of the pandemic. For instance, coordinated ambulatory care often helped avoid overburdening hospitals. Decentralisation among local authorities may however represent challenges with the coordination of policies, i.e. coordination costs. At the same time, bottom-up self-organisation of ambulatory care providers is supported by decentralised structures. Providers also increasingly used teleconsultations, which may remain part of standard practice. It is recommended to involve SHI funds actively in crisis management and in preparing for future crisis to increase health system resilience.

The COVID-19 pandemic has placed unprecedented pressure on health systems' capacities. These capacities include physical infrastructure, such as bed capacities and medical equipment, and healthcare professionals. Based on information extracted from the COVID-19 Health System Reform Monitor, this paper analyses the strategies that 45 countries in Europe have taken to secure sufficient health care infrastructure and workforce capacities to tackle the crisis, focusing on the hospital sector. While pre-crisis capacities differed across countries, some strategies to boost surge capacity were very similar. All countries designated COVID-19 units and expanded hospital and ICU capacities. Additional staff were mobilised and the existing health workforce was redeployed to respond to the surge in demand for care. While procurement of personal protective equipment at the international and national levels proved difficult at the beginning due to global shortages, countries found innovative solutions to increase internal production and enacted temporary measures to mitigate shortages. The pandemic has shown that coordination mechanisms informed by real-time monitoring of available health care resources are a prerequisite for adaptive surge capacity in public health crises, and that closer cooperation between countries is essential to build resilient responses to COVID-19.

This paper compares health policy responses to COVID-19 in Canada, Ireland, the United Kingdom and United States of America (US) from January to November 2020, with the aim of facilitating cross-country learning. Evidence is taken from the COVID-19 Health System Response Monitor, a joint initiative of the European Observatory on Health Systems and Policies, the WHO Regional Office for Europe, and the European Commission, which has documented country responses to COVID-19 using a structured template completed by country experts. We show all countries faced common challenges during the pandemic, including difficulties in scaling-up testing capacity, implementing timely and appropriate containment measures amid much uncertainty and overcoming shortages of health and social care workers, personal protective equipment and other medical technologies. Country responses to address these issues were similar in many ways, but dissimilar in others, reflecting differences in health system organization and financing, political leadership and governance structures. In the US, lack of universal health coverage have created barriers to accessing care, while political pushback against scientific leadership has likely undermined the crisis response. Our findings highlight the importance of consistent messaging and alignment between health experts and political leadership to increase the level of compliance with public health measures, alongside the need to invest in health infrastructure and training and retaining an adequate domestic health workforce. Building on innovations in care delivery seen during the pandemic, including increased use of digital technology, can also help inform development of more resilient health systems longer-term.

This study identifies gaps in universal health coverage in the European Union, using a questionnaire sent to the Health Systems and Policy Monitor network of the European Observatory on Health Systems and Policies. The questionnaire was based on a conceptual framework with four access dimensions: population coverage, service coverage, cost coverage, and service access. With respect to population coverage, groups often excluded from statutory coverage include asylum seekers and irregular residents. Some countries exclude certain social-professional groups (e.g. civil servants) from statutory coverage but cover these groups under alternative schemes. In terms of service coverage, excluded or restricted services include optical treatments, dental care, physiotherapy, reproductive health services, and psychotherapy. Early access to new and expensive pharmaceuticals is a concern, especially for rare diseases and cancers. As to cost coverage, some countries introduced protective measures for vulnerable patients in the form of exemptions or ceilings from user chargers, especially for deprived groups or patients with accumulation of out-of-pocket spending. For service access, common issues are low perceived quality and long waiting times, which are exacerbated for rural residents who also face barriers from physical distance. Some groups may lack physical or mental ability to properly formulate their request for care. Currently, available indicators fail to capture the underlying causes of gaps in coverage and access.

Hungary, like many countries, features a complex mix of the public and private sector in the financing and provision of health care services. At the same time, the health system also faces challenges related to shortages of health professionals, low public financing, and informal payments. With the added pressure from the COVID-19 pandemic, Hungarian policymakers acted rapidly to pass a sweeping regulation aimed at these issues. Over two days, the Hungarian parliament introduced and unanimously approved a new regulation, Act C of 2020 on the Employment Status of Health Workers, that replaces the existing public employment relationship between health professionals, public providers and their controlling authorities. The Act, passed on 6 October 2020, brings the employment of health workers under strict central control by introducing a new employment status similar to that of the armed forces. The Act also provides doctors with an unprecedented 120% salary increase and criminalizes informal payments. The reception has been overwhelmingly negative, with thousands of health professionals indicating that they would not sign the new contracts, and the policy also contains serious technical and feasibility concerns. Although the first statistics show that only about 3-5% of the active workforce did not sign the contract by 1 March 2021, the implementation of the reform still faces serious challenges.

Background At the request of the European Commission, the Observatory on Health Systems and Policies and the HSPM network have undertaken a study to explore gaps in universal health coverage in the European Union and increase the level of granularity in terms of areas or groups where accessibility is sub-optimal. Methods To explore these gaps more systematically a survey was developed based on the so-called cube model that comprises different dimensions determining health coverage, including population coverage, service coverage and cost coverage. In addition, access can also be hampered by other factors, which relate more to the physical availability of care, a person's ability to obtain necessary care or the attitude of the provider. The survey was sent to country contacts from the Health Systems and Policy Monitor network. Results Within the diversity of country cases found in the survey, the most significant barriers for accessing health care still seem to be associated with social and income status, rather than specific medical conditions. However, groups like mentally ill, homeless, frail elderly, undocumented migrants are more likely to face multiple layers of exclusion and complex barriers to access. Conclusions Health system interventions can close access gaps for these vulnerable groups and address inequities in access to care. Through detailed coverage design countries can indeed determine the extent to which financial hardship and catastrophic out-of-pocket spending can be prevented. Furthermore, scope exists to improve current data collection practice.

Natural fibers have been widely used for reinforcing polymers attributed to their sustainable nature, excellent stiffness to weight ratio, biodegradability, and low cost compared with synthetic fibers like carbon or glass fibers. Thermoplastic composites offer an advantage of recyclability after their service life, but challenges and opportunities remain in the recycling of natural fiber reinforced polymer composites (NFRPCs). This article summarized the effects of reprocessing/recycling on the material properties of NFRPCs. The material properties considered include mechanical performance, thermal properties, hygroscopic behavior, viscoelasticity, degradation, and durability. NFRPCs can generally be recycled approximately 4–6 times until their thermomechanical properties change. After recycling 7 times, the tensile strength of NFRPCs can decrease by 17%, and the tensile modulus can decrease by 28%. The mitigation approaches to overcome degradation of material properties of NFRPCs such as adding functional additives and virgin plastics are also discussed. The main challenges in these approaches such as degradation and incompatibility are discussed, and an effort is made to provide a rationale for reprocessing/recyclability assessment. Future applications of NFRPCs such as additive manufacturing and automotive part use are discussed.

In this study, an integrated system of harvesting, collecting, and transporting willow biomass crop to a storage site was modeled and evaluated using the IBSAL simulation model. A scenario analysis was used to quantify the impacts of five major input parameters on the performance of the integrated system. These parameters include parcel size, field shape, willow yield, distance to the storage site, and type of the collection equipment. Multiple performance indicators were identified to quantify the impacts on the system such as size of the equipment fleet, effective material and field capacity of the harvester, operating costs, and waiting times. The input data were collected from 36 commercial, short-rotation, shrub willow fields in northern New York State. The simulation results indicated that crop yield and type of collection equipment have the highest impact on operating costs and the equipment fleet size. As the size of equipment fleet increases in the system, variability in the system performance tends to increase. Field shape has the least impact on the overall system performance compared to the other four input parameters. The simulation results suggest that a combination of performance indicators need to be considered to evaluate the overall performance of the dynamic and complex system of harvesting, collection and transportation in commercial willow fields. The developed IBSAL model and scenario analysis approach can assist in planning this system based on the characteristics of field, crop, and logistical equipment to reach a high system performance.

With a major global emphasis on the management of waste, alternative resources and a shift to environmentally sustainable technologies, demand for large volumes of heterogeneous solid biomass feedstocks for energy or chemical use is expected to rise significantly. In transforming a sporadic supply of a low-value, highly variable product, to continuous and controlled high through-put systems, a thorough understanding of the feedstock properties will increase in importance. Appropriate characterisation tests are necessary to define technical specification and selection criteria for handling equipment and to appraise the requirement and location for additional processes or pre-treatment to be integrated into the handling chain. Such tests may also influence the material characteristics to be used in the conversion process. This paper discusses the main feedstock attributes associated with a number of handling chain phases and the approach to obtain them. The framework for a holistic approach to the characterisation and design of biomass feedstock handling systems for further development and practical implementation is also proposed.

The objective of this research is to estimate the cost of drying microalgae chlorella in a conveyor belt dryer using waste heat from an industrial source. The recycling system consists of a run around thermal fluid between two tube heat exchangers. The dryer is mathematically modeled and the mass transport coefficient is obtained from empirical thin-layer kinetic data. The dryer and heat recovery system are designed for the production of 1000 kg/h dried microalgae at a moisture content of 10% (wet basis, w.b.). The input moisture content can range from 35 to 75% (wet basis). Depending upon the applied Hand factor, the total cost to dry microalgae from 55% to 10% ranges from $46.13 to $109.64 per ton of dried product. Using natural gas assumed at $6.27/GJ, the drying cost increases to $83.47 per ton (using hand factor equal to 1). The drying cost using a commercial spray dryer is $109.05 per ton of dried product (using hand factor equal to 1). The paper discusses the sensitivity of drying costs to initial moisture content as well. The results show that integrating waste heat recovery with conveyor belt dryer decreases the drying costs of chlorella drying in comparison to two other drying methods.

In this paper, three scenarios are considered to quantify the impact of the biorefinery size on the required biomass logistical resources. The biorefinery scenarios include small scale (175 dt/day)-SS, medium scale (520 dt/day)-MS and large scale (860 dt/day)-LS. These scenarios are compared against the following logistical resources (1) harvest area and contracted fields, (2) logistics equipment fleet and the workforce to run this fleet and (3) intermediate storage sites and their biomass inventory levels. To this end, the IBSAL-MC simulation model is applied to a corn stover logistics system in Southwestern Ontario. The obtained results show (1) the harvest area and the number of contracted fields increase by 65% and 78% from the SS scenario to the MS and LS scenarios, respectively, (2) the average biomass delivered costs are estimated to be $82.09, $87.49 and $93.75/dry tonne in the SS, MS and LS scenarios. The increase in the capital costs to develop a dedicated logistics equipment fleet are estimated to be far greater than the increase in the delivered costs as the size of the biorefinery increases. The upfront capital costs are estimated to be $6.72, 21.83 and 35.51 million in these scenarios. To run the logistics equipment fleet efficiently, 37, 136 and 235 well-trained operators are required in the SS, MS ad LS scenarios, respectively, and (3) the inventory level and the land requirement for storage in the MS and LS scenarios are estimated to be 225% and 425% greater than those of the SS scenario. The sensitivity analysis indicates that the logistical resources are highly sensitive to corn yield and farm participation rate. Overall, this study shows the importance of considering the size of the required logistical resources and the associated level of logistical complexity in evaluating the economic viability of a biorefinery project.

The moisture content of a maturing crop varies as the harvest season progresses. For crop residues such as corn stover, moisture content at the time of harvest can be as high as 75% (wet mass basis) to less than 20% depending on the geographic location (climate conditions) and stage of harvest. Biomass moisture content is critical for baling and extended storage. It is therefore essential to have an estimate of the quantities of corn stover available as wet or dry for various parts of the U.S. To this end, we analyzed hourly weather data (temperature, humidity, and rainfall) from the Typical Meteorological Year v.3 (TMY3) dataset developed by the National Renewable Energy Laboratory. A recently published set of equations for calculating the moisture content of stover as a function of hourly temperature, humidity, and rainfall were used. The annual start and end of corn grain harvest along with annual grain production (in bushels) for each state were extracted from USDA National Agricultural Statistics Service reports. Using these datasets and moisture sorption equations, the percentage of corn stover tonnage with moisture content less than 20%, between 20% and 40%, or greater than 40% was estimated from the length of time that the biomass was in these moisture content ranges. These calculations were carried out for several locations within each of the states for which TMY data were available. It was concluded that about 37.2% of corn stover is dry (40% moisture content) nationwide. The remaining 27.0% of corn stover is between 20% and 40% moisture content. Keywords: Corn stover, Equilibrium moisture content, Field drying, Moisture content, Stover harvest, Typical Meteorological Year data.

In this study, the logistical resources required to develop a bioeconomy based on corn stover in the USA are quantified, including field equipment, storage sites, transportation and handling equipment, workforce, corn growers, and corn lands. These resources are essential to mobilize large quantities of corn stover from corn fields to biorefineries. The logistical resources are estimated over the lifetime of the biorefineries. Seventeen corn-growing states are considered for the logistical resource assessment. Over 6.8 billion gallons of cellulosic ethanol can be produced annually from 108 million dry tons of corn stover in these states. The maximum number of required field equipment (i.e., choppers, balers, collectors, loaders, and tractors) is estimated to be 194 110 units with a total economic value of about $26 billion. In addition, 40 780 trucks and flatbed trailers would be required to transport bales from corn fields and storage sites to biorefineries with a total economic value of $4.0 billion. About 88 899 corn growers need to be contracted with an annual net income of over $2.1 billion. About 1903 storage sites would be required to hold 53.1 million dry tons of inventory after the harvest season. These storage sites would take up about 35 320.2 acres and 4077 loaders with an economic value of $0.4 billion would handle this inventory. The total required workforce to run the logistics operations is estimated to be 50 567. The magnitude of the estimated logistical resources demonstrates the economic and social significance of the corn stover bioeconomy in rural areas in the USA. © 2016 Society of Chemical Industry and John Wiley & Sons, Ltd

Advanced biocomposites reinforced by abundant biomass-derived fillers can add a revenue stream to enhance the economic viability of biofuel production chains and the energy efficiency of the composite industry. However, the low stiffness of biopolymers limits their use in structural applications. Poplar fibers (mesh size: l -lysine). As a benefit of the amino acid treatment, the tensile Young's moduli of the lysine/poplar/PLA composites increased by up to 68% with the addition of a small amount of lysine, compared with neat PLA. At the same time, the tensile strength, failure strain, and Young's modulus of the poplar/PLA composites all increased after adding only 0.1 wt % of lysine. It has been observed that the lysine content has a significant effect on the decomposition temperature, complex viscosity, storage modulus, crystallization temperature, and crystallinity of composites. The fracture surfaces of the composites with an optimum lysine content had fewer voids and were more compact compared with composites without any lysine. The pores on the surfaces of poplar fibers became more available for the penetration of PLA molecules as a result of lysine addition. Therefore, this study presents a facile method for reinforcing biocomposites with extremely low-cost and environmentally friendly biofillers.

Lignocellulosic biomass derived fuels and chemicals are a promising and sustainable supplement for petroleum-based products. Currently, the lignocellulosic biofuel industry relies on a conventional system where feedstock is harvested, baled, stored locally, and then delivered in a low-density format to the biorefinery. However, the conventional supply chain system causes operational disruptions at the biorefinery mainly due to seasonal availability, handling problems, and quality variability in biomass feedstock. Operational disruptions decrease facility uptime, production efficiencies, and increase maintenance costs. For a low-value high-volume product where margins are very tight, system disruptions are especially problematic. In this work we evaluate an advanced system strategy in which a network of biomass processing centers (depots) are utilized for storing and preprocessing biomass into stable, dense, and uniform material to reduce feedstock supply disruptions, and facility downtime in order to boost economic returns to the bioenergy industry. A database centric discrete event supply chain simulation model was developed, and the impact of operational disruptions on supply chain cost, inventory and production levels, farm metrics and facility metrics were evaluated. Three scenarios were evaluated for a 7-year time-period: (1) bale-delivery scenario with biorefinery uptime varying from 20 to 85%; (2) pellet-delivery scenario with depot uptime varying from 20 to 85% and biorefinery uptime at 85%; and (3) pellet-delivery scenario with depot and biorefinery uptime at 85%. In scenarios 1 and 2, tonnage discarded at the field edge could be reduced by increasing uptime at facility, contracting fewer farms at the beginning and subsequently increasing contracts as facility uptime increases, or determining alternative corn stover markets. Harvest cost was the biggest contributor to the average delivered costs and inventory levels were dependent on facility uptimes. We found a cascading effect of failure propagating through the system from depot to biorefinery. Therefore, mitigating risk at a facility level is not enough and conducting a system-level reliability simulation incorporating failure dependencies among subsystems is critical.