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Your search keyword '"Erik M. Ness"' showing total 3 results
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3 results on '"Erik M. Ness"'

1. Epidemiologic features of a large hepatitis C cohort evaluated in a major health system in the western United States

Author

Nizar A. Mukhtar, Erik M. Ness, Manan Jhaveri, Oren K. Fix, Marquis Hart, Christopher Dale, Cheryl Pratt, and Kris V. Kowdley

Subjects
HCV epidemiology, Viral hepatitis, Public health, Public policy, Infectious diseases, Specialties of internal medicine, RC581-951
Abstract

Introduction and aim: Real-world epidemiologic data to guide hepatitis C virus (HCV)-related public health initiatives are lacking. The aim of this study was to describe the prevalence and epidemiological characteristics of a large cohort of patients with an HCV diagnosis evaluated in one of the largest health systems in the United States. Materials and methods: De-identified demographic and clinical data were extracted from the electronic health record for patients actively followed within the Providence Health & Services health care system. Rates of HCV prevalence and co-morbid illnesses among HCV-infected patients were determined. Results: Among 2,735,511 active patients, 23,492 (0.86%) were found to have evidence of HCV infection, the majority of which were Caucasian (78.2%) and born between the years 1945 and 1965 (68.3%). In comparison to Caucasians, higher rates of HCV infection were found among Native Americans (2.5% vs. 0.95%, p

Published
2019
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2. Miliary Tuberculosis as a Cause of Acute Empyema

Author

Aaron P. Milstone, Derek C. Welch, Erik M. Ness, James R. Runo, and Ivan M. Robbins

Subjects
Pulmonary and Respiratory Medicine, Tuberculous Empyema, Miliary tuberculosis, ARDS, medicine.medical_specialty, Multiple Organ Failure, Fulminant, Comorbidity, Sepsis, Fatal Outcome, Crohn Disease, medicine, Humans, Intensive care medicine, Aged, Respiratory distress, Tuberculosis, Miliary, business.industry, Respiratory disease, bacterial infections and mycoses, medicine.disease, Shock, Septic, Empyema, respiratory tract diseases, Pleural Effusion, Empyema, Tuberculous, Acute Disease, Female, business
Abstract

Adult respiratory distress syndrome (ARDS) and sepsis are known, life-threatening complications of miliary tuberculosis. This report describes a patient with miliary tuberculosis who rapidly developed an acute tuberculous empyema. She had a fulminant course culminating in ARDS, sepsis and subsequent death. This case highlights the rare association of acute empyema with miliary tuberculosis.

Published
2003
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3. Gastric graft-versus-host disease revisited: does proton pump inhibitor therapy affect endoscopic gastric biopsy interpretation?

Author

James R. Goldenring, Kay Washington, Derek C. Welch, Erik M. Ness, Pamela S. Wirth, and Madan Jagasia

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Adolescent, medicine.drug_class, Biopsy, H&E stain, Stomach Diseases, Proton-pump inhibitor, Graft vs Host Disease, Apoptosis, Gastroenterology, Pathology and Forensic Medicine, Postoperative Complications, Internal medicine, Gastrins, medicine, Pyloric Antrum, Humans, Gastric Fundus, Enzyme Inhibitors, Child, Antrum, Gastrin, medicine.diagnostic_test, business.industry, Infant, Anatomical pathology, Proton Pump Inhibitors, Middle Aged, Apoptotic body, medicine.disease, Immunohistochemistry, digestive system diseases, surgical procedures, operative, Graft-versus-host disease, Child, Preschool, Surgery, Female, Anatomy, business, Biomarkers, Stem Cell Transplantation
Abstract

Accurate diagnosis of gastrointestinal graft-versus-host disease (GvHD) is important, as it contributes significantly to postallogeneic stem cell transplant (SCT) morbidity and mortality. To test the hypothesis that proton pump inhibitor (PPI) therapy may interfere with histologic evaluation of gastric GvHD by inducing apoptosis, we evaluated epithelial apoptotic body counts in antral and fundic biopsies from SCT recipients and control patients, both taking and not taking PPIs at the time of endoscopic biopsy. Hematoxylin and eosin-stained slides of gastric biopsies from 130 patients (75 allogeneic SCT with GvHD on clinical and histologic grounds, and a comparison group of 55 age- and sex-matched nontransplant patients with histologically normal gastric biopsies) were reviewed. The groups were further stratified into patients taking (PPI+) and not taking PPIs (PPI-) at the time of biopsy. Apoptotic bodies (AB)/10 (400 x) high power fields (HPF) were quantified for each case. Mean apoptotic body counts were then calculated for each case group. Seventy antral cases (31 control and 39 transplant) were also evaluated via gastrin immunohistochemistry, and the mean number of gastrin positive cells/400 x HPF calculated. In the PPI- groups, apoptosis was increased in biopsies from transplant patients, compared with controls, both in antral and fundic mucosa. In PPI+ patients, there was significantly more apoptosis in the gastric body in transplant patients than in controls. However, comparing antral biopsies from control and transplant PPI+ patients, there was no significant difference in AB quantitation. More apoptosis was seen in antral biopsies from PPI+ control patients when compared with PPI- control patients (P = 0.009). Mean numbers of gastrin positive cells/400 x HPF were increased in both control and transplant patients taking PPIs (85 and 58, respectively) compared with samples from those patients not taking PPIs (48 and 51, respectively). PPI therapy is associated with increased apoptosis in antral biopsies and may interfere with the evaluation of GvHD in biopsies from this site. A similar increase in apoptosis was not seen in fundic biopsies; biopsy of the gastric fundus rather than antrum may be preferable for the diagnosis of upper gastrointestinal GvHD.

Published
2006

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