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2 results on '"Erica M Dawsey"'

1. Comparison of global gene expression of gastric cardia and noncardia cancers from a high-risk population in china.

Author

Gangshi Wang, Nan Hu, Howard H Yang, Lemin Wang, Hua Su, Chaoyu Wang, Robert Clifford, Erica M Dawsey, Jian-Min Li, Ti Ding, Xiao-You Han, Carol Giffen, Alisa M Goldstein, Philip R Taylor, and Maxwell P Lee

Subjects
Medicine, Science
Abstract

To profile RNA expression in gastric cancer by anatomic subsites as an initial step in identifying molecular subtypes and providing targets for early detection and therapy.We performed transcriptome analysis using the Affymetrix GeneChip U133A in gastric cardia adenocarcinomas (n = 62) and gastric noncardia adenocarcinomas (n = 72) and their matched normal tissues from patients in Shanxi Province, and validated selected dysregulated genes with additional RNA studies. Expression of dysregulated genes was also related to survival of cases.Principal Component Analysis showed that samples clustered by tumor vs. normal, anatomic location, and histopathologic features. Paired t-tests of tumor/normal tissues identified 511 genes whose expression was dysregulated (P

Published
2013
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2. Comparison of global gene expression of gastric cardia and noncardia cancers from a high-risk population in china

Author

Robert J. Clifford, Carol Giffen, Maxwell P. Lee, Jian-min Li, Alisa M. Goldstein, Nan Hu, Chaoyu Wang, Gangshi Wang, Lemin Wang, Hua Su, Ti Ding, Philip R. Taylor, Howard H. Yang, Erica M. Dawsey, and Xiao-You Han

Subjects
Oncology, Male, Epidemiology, Gene Expression, lcsh:Medicine, Bioinformatics, Transcriptome, Gene expression, lcsh:Science, Early Detection of Cancer, Stomach and Duodenum, education.field_of_study, Multidisciplinary, Cardia, Genomics, Middle Aged, Up-Regulation, Genetic Epidemiology, Adenocarcinoma, Medicine, Female, Research Article, medicine.medical_specialty, China, Population, Down-Regulation, Gastroenterology and Hepatology, Biology, Stomach Neoplasms, Internal medicine, Gastrointestinal Tumors, medicine, Cancer Detection and Diagnosis, Early Detection, Humans, education, Gene Expression Profiling, lcsh:R, RNA, Cancer, Cancers and Neoplasms, medicine.disease, digestive system diseases, Gene expression profiling, Gastric Cancer, lcsh:Q, Genome Expression Analysis, GASTRIC CARDIA
Abstract

Objective To profile RNA expression in gastric cancer by anatomic subsites as an initial step in identifying molecular subtypes and providing targets for early detection and therapy. Methods We performed transcriptome analysis using the Affymetrix GeneChip U133A in gastric cardia adenocarcinomas (n = 62) and gastric noncardia adenocarcinomas (n = 72) and their matched normal tissues from patients in Shanxi Province, and validated selected dysregulated genes with additional RNA studies. Expression of dysregulated genes was also related to survival of cases. Results Principal Component Analysis showed that samples clustered by tumor vs. normal, anatomic location, and histopathologic features. Paired t-tests of tumor/normal tissues identified 511 genes whose expression was dysregulated (P

Published
2013

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