1. Emmprin Promotes Anchorage-Independent Growth in Human Mammary Carcinoma Cells by Stimulating Hyaluronan Production
- Author
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Alexandra Zoltan-Jones, Suniti Misra, Erica A. Marieb, Shibnath Ghatak, Bryan P. Toole, Rongsong Li, Jian Cao, and Stanley Zucker
- Subjects
Cancer Research ,medicine.medical_specialty ,Cell Survival ,Mammary gland ,Breast Neoplasms ,Matrix metalloproteinase ,Antigens, CD ,Antigens, Neoplasm ,In vivo ,Cell Line, Tumor ,Internal medicine ,medicine ,Carcinoma ,Humans ,Hyaluronic Acid ,Membrane Glycoproteins ,biology ,Chemistry ,medicine.disease ,Membrane glycoproteins ,Endocrinology ,medicine.anatomical_structure ,Oncology ,Basigin ,Cancer cell ,biology.protein ,Cancer research ,Female ,Anchorage-Independent Growth ,Cell Division - Abstract
Emmprin (CD147; basigin) is a plasma membrane glycoprotein, enriched on the surface of many cancer cells, which induces matrix metalloproteinase synthesis via cell-cell interactions. Elevated emmprin production causes increased growth in vivo of human mammary carcinoma cells. In this study, we show that elevation of emmprin expression in less aggressive human carcinoma cells, which normally express low emmprin levels, induces the ability to grow under anchorage-independent conditions. We also found that elevated emmprin expression stimulates hyaluronan production and that the effect of emmprin on anchorage-independent growth is dependent on hyaluronan. Furthermore, emmprin stimulates cell survival pathway signaling in a hyaluronan-dependent manner. From these and other studies we conclude that emmprin enhances several malignant properties of cancer cells, including anchorage-independent growth, invasiveness, and chemoresistance.
- Published
- 2004
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