1. Association of interleukin-1β -511 C/T polymorphism with tobacco-associated cancer in northeast India: a study on oral and gastric cancer
- Author
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Khangembam Jitenkumar Singh, Santhi P. Latha, Jagannath Dev Sharma, Thoudam Regina Devi, Meena Lakhanpal, Sujala Kapur, Yogesh Verma, Amal Chandra Kataki, Pradeep Singh Chauhan, Eric Zomavia, Sunita Saxena, Laishram Chandreshwor Singh, and Dhirendra Singh Yadav
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Tobacco, Smokeless ,Alcohol Drinking ,Genotype ,Interleukin-1beta ,India ,Biology ,Gastroenterology ,Polymorphism, Single Nucleotide ,Risk Factors ,Stomach Neoplasms ,Internal medicine ,Genetic model ,Tobacco ,Genetics ,medicine ,Odds Ratio ,Humans ,Genetic Predisposition to Disease ,Significant risk ,Allele ,Molecular Biology ,Alleles ,Areca ,Aged ,Confounding ,Smoking ,Sequence Analysis, DNA ,Middle Aged ,Interleukin 1β ,Increased risk ,Case-Control Studies ,Female ,Mouth Neoplasms ,Restriction fragment length polymorphism ,Polymorphism, Restriction Fragment Length - Abstract
The IL-1β -511 C/T polymorphism is associated with increased IL-1 production and with increased risk of developing cancers. In this study, 251 patients (125 with gastric cancer [GC] and 126 with oral cancer [OC]) and 207 normal controls from northeast (NE) India were genotyped for the IL-1β -511 C/T polymorphism by PCR-restriction fragment length polymorphism (RFLP) and sequencing. Analysis of results showed betel-quid chewing to be a major risk factor (OR = 2.01, 95% CI = 1.05-3.87; P = 0.035) for OC. Inheritance of the IL-1β -511 CT or TT resulted in a 2.6- to 3.05-fold increase in the risk of developing OC relative to that of participants who possessed the reference genotype (OR = 2.57, 95% CI = 1.06-6.22; P = 0.036 and OR = 3.05, 95% CI = 1.22-7.63; P = 0.017), after adjusting for potential confounders. The dominant genetic model also confirmed the presence of the T allele as a significant risk factor for OC (OR = 2.72, 95% CI = 1.15-6.42; P = 0.02). In GC, interaction of the CT genotype with tobacco and betel-quid chewing habits conferred a significant 78% and 89% reduced risk of cancer, respectively. In conclusion, for the NE Indian population, the IL-1β -511 CC and CT genotypes were significantly associated with increased risk of OC. However, the interaction of the CT genotype with risk habits may play a preventive role for GC but not for OC.
- Published
- 2013