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Purpose Bariatric surgery has a favorable effect on fertility in women. However, due to a lack of data regarding children’s outcomes, the ideal time for conception following bariatric surgery is unknown. Current guidelines advise avoiding pregnancy during the initial weight loss phase (12–24 months after surgery) as there may be potential risks to offspring. Thus, we aimed to analyze health outcomes in children born to mothers who had undergone bariatric surgery. The surgery-to-delivery interval was studied. Materials and Methods A nationwide registry belonging to the Austrian health insurance funds and containing health-related data claims was searched. Data for all women who had bariatric surgery in Austria between 01/2010 and 12/2018 were analyzed. A total of 1057 women gave birth to 1369 children. The offspring’s data were analyzed for medical health claims based on International Classification of Diseases (ICD) codes and number of days hospitalized. Three different surgery-to-delivery intervals were assessed: 12, 18, and 24 months. Results Overall, 421 deliveries (31%) were observed in the first 2 years after surgery. Of these, 70 births (5%) occurred within 12 months after surgery. The median time from surgery to delivery was 34 months. Overall, there were no differences noted in frequency of hospitalization and diagnoses leading to hospitalization in the first year of life, regardless of the surgery-to-delivery interval. Conclusion Pregnancies in the first 24 months after bariatric surgery were common. Importantly, the surgery-to-delivery interval had no significant impact on the health outcome of the children. Graphical Abstract

Purpose Bariatric surgery reduces mortality in patients with severe obesity and is predominantly performed in women. Therefore, an analysis of sex-specific differences after bariatric surgery in a population-based dataset from Austria was performed. The focus was on deceased patients after bariatric surgery. Materials and Methods The Austrian health insurance funds cover about 98% of the Austrian population. Medical health claims data of all Austrians who underwent bariatric surgery from 01/2010 to 12/2018 were analyzed. In total, 19,901 patients with 107,806 observed years postoperative were eligible for this analysis. Comorbidities based on International Classification of Diseases (ICD)-codes and drug intake documented by Anatomical Therapeutical Chemical (ATC)-codes were analyzed in patients deceased and grouped according to clinically relevant obesity-associated comorbidities: diabetes mellitus (DM), cardiovascular disease (CV), psychiatric disorder (PSY), and malignancy (M). Results In total, 367 deaths were observed (1.8%) within the observation period from 01/2010 to 04/2020. The overall mortality rate was 0.34% per year of observation and significantly higher in men compared to women (0.64 vs. 0.24%; p p p = 0.034), whereas malignant diseases (36%) were more frequent in women (30 vs. 41%; p = 0.025). Conclusion After bariatric surgery, short-term mortality as well as long-term mortality was higher in men compared to women. In deceased patients, diabetes was more common in men, whereas malignant diseases were more common in women. Graphical abstract

Visual stories are an effective and powerful tool to convey specific information to a diverse public. Scrollytelling is a recent visual storytelling technique extensively used on the web, where content appears or changes as users scroll up or down a page. By employing the familiar gesture of scrolling as its primary interaction mechanism, it provides users with a sense of control, exploration and discoverability while still offering a simple and intuitive interface. In this paper, we present a novel approach for authoring, editing, and presenting data-driven scientific narratives using scrollytelling. Our method flexibly integrates common sources such as images, text, and video, but also supports more specialized visualization techniques such as interactive maps as well as scalar field and mesh data visualizations. We show that scrolling navigation can be used to traverse dynamic narratives and demonstrate how it can be combined with interactive parameter exploration. The resulting system consists of an extensible web-based authoring tool capable of exporting stand-alone stories that can be hosted on any web server. We demonstrate the power and utility of our approach with case studies from several of diverse scientific fields and with a user study including 12 participants of diverse professional backgrounds. Furthermore, an expert in creating interactive articles assessed the usefulness of our approach and the quality of the created stories.

Bariatric surgery has a favorable effect on fertility in women. However, due to a lack of data regarding children's outcomes, the ideal time for conception following bariatric surgery is unknown. Current guidelines advise avoiding pregnancy during the initial weight loss phase (12-24 months after surgery) as there may be potential risks to offspring. Thus, we aimed to analyze health outcomes in children born to mothers who had undergone bariatric surgery. The surgery-to-delivery interval was studied.A nationwide registry belonging to the Austrian health insurance funds and containing health-related data claims was searched. Data for all women who had bariatric surgery in Austria between 01/2010 and 12/2018 were analyzed. A total of 1057 women gave birth to 1369 children. The offspring's data were analyzed for medical health claims based on International Classification of Diseases (ICD) codes and number of days hospitalized. Three different surgery-to-delivery intervals were assessed: 12, 18, and 24 months.Overall, 421 deliveries (31%) were observed in the first 2 years after surgery. Of these, 70 births (5%) occurred within 12 months after surgery. The median time from surgery to delivery was 34 months. Overall, there were no differences noted in frequency of hospitalization and diagnoses leading to hospitalization in the first year of life, regardless of the surgery-to-delivery interval.Pregnancies in the first 24 months after bariatric surgery were common. Importantly, the surgery-to-delivery interval had no significant impact on the health outcome of the children.

Zusammenfassung Hintergrund Die Kontrolle einer myoelektrischen Prothese erfordert ein umfangreiches rehabilitatives Training, welches auf repetitiven Übungen basiert, angeleitet unter physiotherapeutischer Aufsicht. Doch zuhause fehlt vielen Patienten die Motivation, die Übungen aus der Physiotherapie weiterzuführen. Mobile Spiele auf dem Smartphone können zu einer Langzeit-Motivation beitragen, das Heimtraining mit der notwendigen Intensität fortzuführen. Patienten und Methodik Wir entwickelten ein Trainingssystem, welches aus einer spielbasierten mobilen Rehabilitationsanwendung besteht, die mit dem Muskelsignal des Patienten gesteuert wird, außerdem einem Tablett zum Spielen der App, einem Elektrodenarmband und einem Handbuch. Bisher haben zwei Patienten an dieser Studie teilgenommen. Sie wurden gebeten die App für 4 Wochen zu Hause, 5 Mal pro Woche, für 10 bis 15 Minuten zu benutzen. Gemäß eines Prä- und Post-Test-Designs wurden die neuromuskulären Parameter der Patienten vor und nach dem mobilen Training untersucht. Evaluiert wurden u. a. die maximale Kontraktionskraft, Muskelseparation, proportionale Ansteuerung und Muskelausdauer, sowie die Nutzerstatistiken während der App-Benutzung. Resultate Nach dem Training mit der App konnte eine signifikante Verbesserung (p Conclusio Die Trainings-App „MyoBeatz“ bietet nicht nur Anleitung und Feedback zur korrekten Ausführung von myoelektrischen Kommandos, sondern erhält auch die Motivation des Patienten durch verschiedene Spielmodi und Feedbackelemente. Durch eine Übersicht des Trainingsfortschritts in Form von Nutzer-Statistiken und Highscores kann der Rehabilitationsprozess überwacht und verglichen werden. Es konnte gezeigt werden, dass Patienten mit Amputation der oberen Extremität nach der Nutzung der spielbasierten App ihre neuromuskuläre Kontrolle, Kraft und Koordination signifikant verbessern konnten, so dass sie das Potential einer myoelektrischen Prothese voll ausschöpfen können.

Multiparametric imaging in cancer has been shown to be useful for tumor detection and may also depict functional tumor characteristics relevant for clinical phenotypes. However, when confronted with datasets consisting of multiple values per voxel, traditional reading of the imaging series fails to capture complicated patterns. These patterns of potentially important imaging properties of the parameter space may be critical for the analysis, but standard approaches do not deliver sufficient details. Therefore, in this paper, we present an approach that aims to enable the exploration and analysis of such multiparametric studies using an interactive visual analysis application to remedy the trade-offs between details in the value domain and in spatial resolution. This may aid in the discrimination between healthy and cancerous tissue and potentially highlight metastases that evolved from the primary tumor. We conducted an evaluation with eleven domain experts from different fields of research to confirm the utility of our approach.

Better understanding of the complex processes driving tumor growth and metastases is critical for developing targeted treatment strategies in cancer. Radiomics extracts large amounts of features from medical images which enables radiomic tumor profiling in combination with clinical markers. However, analyzing complex imaging data in combination with clinical data is not trivial and supporting tools aiding in these exploratory analyses are presently missing. In this paper, we present an approach that aims to enable the analysis of multiparametric medical imaging data in combination with numerical, ordinal, and categorical clinical parameters to validate established and unravel novel biomarkers. We propose a hybrid approach where dimensionality reduction to a single axis is combined with multiple linked views allowing clinical experts to formulate hypotheses based on all available imaging data and clinical parameters. This may help to reveal novel tumor characteristics in relation to molecular targets for treatment, thus providing better tools for enabling more personalized targeted treatment strategies. To confirm the utility of our approach, we closely collaborate with experts from the field of gynecological cancer imaging and conducted an evaluation with six experts in this field. acceptedVersion

Control of a myoelectric prostheses entails rehabilitative training, based on repetitive exercises with a physiotherapist. However, many patients lack the motivation to continue the exercises in their home environment. Mobile games on the smartphone can provide patients with long-term motivation to continue the repetitive exercises that prepare the muscles for controlling a prosthesis at home. The aim of this study was to confirm the feasibility of a myoelectrical controlled mobile application and the impact of this game-based rehabilitation on the patient's maximum voluntary contraction strength, proportionally activated muscle contraction and ability to separate muscle groups.We developed a training system that consisted of a game-based mobile rehabilitation application that is controlled by the patient's muscle signal, a tablet to play on, an electrode armband and a manual. So far two patients have participated in this study. They were asked to use the app for 4 weeks at home, 5 times a week, for 10 to 15 minutes. The intervention was designed in a randomised controlled pre-test/post-test design and patients were measured for neuromuscular parameters before the intervention and afterwards. Evaluated parameters included maximum voluntary contraction force, muscle separation, proportional control and muscle endurance, as well as user statistics.After training with the app, a significant improvement (p .01) in all examined clinical parameters for myoelectric control of a prosthesis could be achieved. The user statistics showed a high motivation to play the game and ran an additional diagnostic EMG-Test on one patient; the other participating patient, however, had played the game but neglected the EMG test and only completed half of it.The training app not only provides instruction and feedback on the correct execution of myoelectric commands, but also maintains patient motivation through various game modes and feedback elements. The rehabilitation process could be monitored and compared through an overview of training progress in the form of user statistics and high scores. It could be shown that patients with upper extremity amputation could significantly improve their neuromuscular control, strength and coordination after using the game-based app so that they can fully benefit from the potential of a myoelectric prosthesis.Die Kontrolle einer myoelektrischen Prothese erfordert ein umfangreiches rehabilitatives Training, welches auf repetitiven Übungen basiert, angeleitet unter physiotherapeutischer Aufsicht. Doch zuhause fehlt vielen Patienten die Motivation, die Übungen aus der Physiotherapie weiterzuführen. Mobile Spiele auf dem Smartphone können zu einer Langzeit-Motivation beitragen, das Heimtraining mit der notwendigen Intensität fortzuführen.Wir entwickelten ein Trainingssystem, welches aus einer spielbasierten mobilen Rehabilitationsanwendung besteht, die mit dem Muskelsignal des Patienten gesteuert wird, außerdem einem Tablett zum Spielen der App, einem Elektrodenarmband und einem Handbuch. Bisher haben zwei Patienten an dieser Studie teilgenommen. Sie wurden gebeten die App für 4 Wochen zu Hause, 5 Mal pro Woche, für 10 bis 15 Minuten zu benutzen. Gemäß eines Prä- und Post-Test-Designs wurden die neuromuskulären Parameter der Patienten vor und nach dem mobilen Training untersucht. Evaluiert wurden u. a. die maximale Kontraktionskraft, Muskelseparation, proportionale Ansteuerung und Muskelausdauer, sowie die Nutzerstatistiken während der App-Benutzung.Nach dem Training mit der App konnte eine signifikante Verbesserung (p .01) aller untersuchten klinischen Parameter zur myoelektrischen Steuerung einer Prothese erzielt werden. Die Nutzerstatistiken ließen eine hohe Motivation zur Benutzung des Spiels und dem zusätzlichen Ausführen eines diagnostischen EMG-Tests bei einem Patienten erkennen, der andere teilnehmende Patient jedoch hatte zwar das Spiel gespielt, jedoch den EMG-Test vernachlässigt und diesen nur zur Hälfte absolviert.Die Trainings-App „MyoBeatz“ bietet nicht nur Anleitung und Feedback zur korrekten Ausführung von myoelektrischen Kommandos, sondern erhält auch die Motivation des Patienten durch verschiedene Spielmodi und Feedbackelemente. Durch eine Übersicht des Trainingsfortschritts in Form von Nutzer-Statistiken und Highscores kann der Rehabilitationsprozess überwacht und verglichen werden. Es konnte gezeigt werden, dass Patienten mit Amputation der oberen Extremität nach der Nutzung der spielbasierten App ihre neuromuskuläre Kontrolle, Kraft und Koordination signifikant verbessern konnten, so dass sie das Potential einer myoelektrischen Prothese voll ausschöpfen können.