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The concept of value, in a context of higher education institutions (HEIs), simply refers to meeting or exceeding customer requirements and expectations. HEIs have a fundamental role in the dissemination of knowledge, in addition to developing new skills and awareness for future professionals, in relation to local, regional and national issues. The aim of this research is to analyse the academic activities and outcomes influence on value generation perception in a public university students' perspective. A survey, built from a structured questionnaire, was carried out in a Brazilian HEI, the Federal University of Santa Maria, with students who are in their course final stage. Data collection came out with a valid sample of 389 respondents. It was analysed using descriptive statistics, exploratory factor and regression analyses. The findings suggest that among the services and resources that the university may offer to its students, the ones that present the most impact refer to cognitive and social abilities emerging from specific teaching practices and strategies from the professors. This research presents useful insights and applicable elements from which public managers can utilize to enhance engagement, create value and build a more rigorous and relevant practice.

Brewer’s spent grain (BSG) and spent coffee ground (SCG) are solid sidestreams from beverage production increasingly being upcycled into food, feed and other value-added products. These solid sidestreams are prone to microbial spoilage, negatively impacting their upcycling potential. Three samples each of BSG and SCG were obtained from generators and recycling facilities in Singapore, and their chemical, elemental, and microbial composition was characterized. The spoilage mechanisms were investigated during storage under anaerobic and aerobic conditions. Bacterial loads of sidestreams were low from craft brewery and café sources (10 CFU/g) and high from recycling facilities (>6 log10 CFU/g). The microbiome of BSG from recycling facilities was dominated by Bacilli, and B. coagulans was identified as the most prevalent species. SCG from recycling facilities was dominated by lactic acid bacteria, with L. panis being the most prevalent species. Storage up to 14 days under anaerobic conditions led to further bacterial proliferation mainly by Bacilli, lactic acid bacteria, and acetic acid bacteria, while aerobic storage led to extensive fungal contamination, including potential aflatoxin-producing Aspergillus flavus. The results shed light on the spoilage mechanisms, while highlighting the short shelf-life and food safety risks of BSG and SCG to inform valorization strategies.

Purpose: As few studies have explored the causal relationship between both the triple bottom line (TBL) of sustainability and the lean practices in higher education institutions (HEIs), the purpose of this paper is to analyze the relationships between lean practices and sustainable practices in Brazilian HEIs. Design/methodology/approach: A survey was conducted with 454 public and private HEIs workers in Brazil. Confirmatory factor analysis and structural equations modeling were used for data analysis. Findings: The results support the hypotheses of the study that HEI lean practices are positively related to environmental, economic and social practices in HEIs. Practical implications: HEI managers must evaluate the use of lean practices in the organizational processes, to identify their weaknesses and to improve the aspects that influence a balanced TBL of sustainability practices. Social implications: The findings highlight the importance of leadership as a support for the workers, as a continuous improvement practice on a daily basis and a focus on the student as a basic principle of HEI success. Originality/value: This article provides new measurement and structural models to analyze Lean thinking practices as the predictors of sustainability practices. The work could assist any HEI in prioritizing its strategies and actions and to contribute to excellence in decision-making. This study could contribute as a source of empirical data for transferability in other contexts for HEIs.

Abstract Background Early access program (formerly cohort Temporary Authorization for Use) was granted for trastuzumab deruxtecan (T‐DXd) in France based on DESTINY‐Breast01 trial which demonstrated its efficacy and safety in HER2‐positive metastatic/unresectable breast cancer after ≥2 anti‐HER2‐based regimens received at metastatic stage. Methods This multicenter real‐world early access program included HER2‐positive metastatic/unresectable breast patients pretreated with at least two lines of anti‐HER2 regimens who received T‐DXd 5.4 mg/kg intravenously in monotherapy every 3 weeks. Results Four hundred and fifty‐nine patients (median age, 58 years; hormone receptor‐positive, 67%; brain metastases, 28.1%) received T‐DXd. Before inclusion, 81.7% of patients had radiation therapy and 76.5% had undergone surgery. Median number of prior metastatic treatment lines was four (range, 2–22); 99.8% patients had received trastuzumab, 94.8% trastuzumab emtansine and 79.3% pertuzumab. Follow‐up was performed from September 30, 2020 to March 30, 2021; when the early access program stopped, the median duration of T‐DXd treatment was 3.4 (range, 0–7.8) months. In 160 patients with available tumor assessment, objective response rate was 56.7% and 12.1% had progression. In 57 patients with available brain tumor assessment, complete or partial intracranial response was reported for 35.7% patients and 5.4% had progression. A total of 17 (3.7%) patients with interstitial lung disease (ILD) was reported with no cases of ILD‐related death. Conclusions In this early access program in patients with heavily pretreated HER2‐positive metastatic/unresectable breast cancer, T‐DXd had antitumor activity with a similar response to that reported in previous clinical studies. T‐DXd was well tolerated and no new safety signals were observed.

Security has always been a significant concern since the dawn of human civilization. That is why we build houses to keep ourselves and our belongings safe. And we do not hesitate to spend a lot on front-door locks and install CCTV cameras to monitor security threats. This paper presents an innovative automatic Front Door Security (FDS) algorithm that uses Human Activity Recognition (HAR) to detect four different security threats at the front door from a real-time video feed with 73.18% accuracy. The activities are recognized using an innovative combination of GoogleNet-BiLSTM hybrid network. This network receives the video feed from the CCTV camera and classifies the activities. The proposed algorithm uses this classification to alert any attempts to break the door by kicking, punching, or hitting. Furthermore, the proposed FDS algorithm is effective in detecting gun violence at the front door, which further strengthens security. This Human Activity Recognition (HAR)-based novel FDS algorithm demonstrates the potential of ensuring better safety with 71.49% precision, 68.2% recall, and an F1-score of 0.65.

Featured Application: Storage conditions for solid sidestreams for improved shelf-life and safety of upcycled products such as food, feed, and value-added products. Brewer's spent grain (BSG) and spent coffee ground (SCG) are solid sidestreams from beverage production increasingly being upcycled into food, feed and other value-added products. These solid sidestreams are prone to microbial spoilage, negatively impacting their upcycling potential. Three samples each of BSG and SCG were obtained from generators and recycling facilities in Singapore, and their chemical, elemental, and microbial composition was characterized. The spoilage mechanisms were investigated during storage under anaerobic and aerobic conditions. Bacterial loads of sidestreams were low from craft brewery and café sources (<1 and 3.53 ± 0.03 log10 CFU/g) and high from recycling facilities (>6 log10 CFU/g). The microbiome of BSG from recycling facilities was dominated by Bacilli, and B. coagulans was identified as the most prevalent species. SCG from recycling facilities was dominated by lactic acid bacteria, with L. panis being the most prevalent species. Storage up to 14 days under anaerobic conditions led to further bacterial proliferation mainly by Bacilli, lactic acid bacteria, and acetic acid bacteria, while aerobic storage led to extensive fungal contamination, including potential aflatoxin-producing Aspergillus flavus. The results shed light on the spoilage mechanisms, while highlighting the short shelf-life and food safety risks of BSG and SCG to inform valorization strategies. [ABSTRACT FROM AUTHOR]

Controversial recent research suggests Americans with more authoritarian tendencies showed less concern about COVID-19 and self-report less mask wearing. The present study set out to replicate this result with a larger sample. The study also sought to extend the original research by investigating how the Dark Triad traits of narcissism, psychopathy, and Machiavellianism are related 1 COVID-19 attitudes and behaviors. Nine-hundred ninety-six United States high school graduates were asked 8 questions about their level of concern about the effects of the virus on health and finances, how frequently they wore masks, which authority figures they trusted, and whether China was responsible for the virus. Correlational and regression analyzes showed that authoritarianism, Machiavellianism, narcissism, and psychopathy were all negatively related to self-reported mask wearing. An explanation is offered for an apparent contradiction between the presented results and studies that showed authoritarian support for lockdowns early during the outbreak.

Raspberry ketone (RK) has high commercial value in the food and healthcare industries. A biological route to this flavour compound is an attractive prospect, considering the need to meet consumer demands and sustainable goals; however, it is yet to become an industrial reality. In this work, fungal production of raspberry ketone (RK) and raspberry compounds (RC) via submerged fermentation of Nidula niveo-tomentosa was characterized in flask, stirred-tank reactor (STR), panel bioreactor (PBR), and fluidized bed reactor (FBR) configurations. The results indicate that the panel bioreactor resulted in larger, floccose pellets accompanied by maximum titres of 20.6 mg/L RK and 50.9 mg/L RC. The stirred-tank bioreactor with impeller mixing yielded compact elliptical pellets, induced the highest volumetric productivity of 2.0 mg L−1 day−1, and showed RK selectivity of 0.45. While differing mixing strategies had clear effects on pellet morphology, RK production presented a more direct positive relationship with cultivation conditions, and showed appropriate mixing and aeration favour RK to raspberry alcohol (RA). Overall, this paper highlights the importance of bioreactor design to fungal fermentation, and gives insight into green and industrial bioproduction of value-added natural compounds.

The concept of value, in a context of higher education institutions (HEIs), simply refers to meeting or exceeding customer requirements and expectations. HEIs have a fundamental role in the dissemination of knowledge, in addition to developing new skills and awareness for future professionals, in relation to local, regional and national issues. The aim of this research is to analyse the academic activities and outcomes influence on value generation perception in a public university students' perspective. A survey, built from a structured questionnaire, was carried out in a Brazilian HEI, the Federal University of Santa Maria, with students who are in their course final stage. Data collection came out with a valid sample of 389 respondents. It was analysed using descriptive statistics, exploratory factor and regression analyses. The findings suggest that among the services and resources that the university may offer to its students, the ones that present the most impact refer to cognitive and social abilities emerging from specific teaching practices and strategies from the professors. This research presents useful insights and applicable elements from which public managers can utilize to enhance engagement, create value and build a more rigorous and relevant practice. [ABSTRACT FROM AUTHOR]