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4. Characteristics of arthritis in patients with familial Mediterranean fever.

Author

Yenigun, Selcan, Ayla, Ali Yagiz, Yuzbasioglu, Mebrure B., Baspinar, Sura N., Ergun, Sercan, Karabicek, Ali, Belli, Cagri, Demirkol, Fatma, Ozdogan, Huri, and Ugurlu, Serdal

Subjects
AUTOINFLAMMATORY diseases, SYMPTOMS, RETROSPECTIVE studies, DESCRIPTIVE statistics, DISEASE remission, TREATMENT effectiveness, COLCHICINE, ARTHRITIS, MEDICAL records, ACQUISITION of data, GENETIC mutation, COMORBIDITY, DRUG resistance
Abstract

Background: Many of the familial Mediterranean fever (FMF) patients present with arthritis during attacks, which may vary in its characteristics. Aims: In this study, we aimed to describe and characterise arthritis in FMF patients. Methods: We used our hospital's record system to retrospectively identify FMF patients with arthritis who presented to our clinic between 2005 and 2020. The prevalence, laboratory results of attack, remission periods, genetic mutations, demographic data, characteristics of attacks, characteristics of arthritis, comorbidities, treatments and treatment responses were recorded. Results: Nine hundred fifty‐four patients from a cohort of 2350 FMF patients had arthritis (40%). The male/female ratio was 0.49 in patients with arthritis. The frequency of at least one exon 10 mutation was high. The age of onset of symptoms was earlier for patients with arthritis. Monoarticular pattern was more frequent compared to oligo‐ and polyarticular patterns. Colchicine resistance was higher; the required colchicine dose for disease control and the frequency of use of biological agents were higher compared to general FMF population. Conclusion: Since M694V mutation is common and the colchicine dose required for disease control is high, we can conclude that the disease activity is high in FMF patients with arthritis. The frequency of sacroiliitis and spondyloarthropathy is significantly increased, especially in individuals with M694V mutation, suggesting that there may be a common pathway in their pathogenesis. FMF should be included in the differential diagnosis in patients presenting with arthritis in FMF endemic regions. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Investigating the relationship of seminal oxidative damage with smoking and occupations in infertile men with normal semen parameters.

Author

Hekim, Neslihan, Gunes, Sezgin, Ulusoy, Oguz, Ergun, Sercan, and Asci, Ramazan

Subjects
SMOKING, MALE infertility, SEMEN, ENZYME-linked immunosorbent assay, OCCUPATIONS
Abstract

Aim: The study aimed to assess the level of seminal oxidative damage in normozoospermic infertile patients by evaluating 8-OHdG and also to analyze the relationship between oxidative damage in infertility and factors such as smoking, occupation and age. Materials and Methods: Seminal plasma samples were obtained from raw semen samples from 13 normozoospermic infertile men among the patients who applied to Ondokuz Mayis University Urology Clinics for fertility evaluation and 10 normozoospermic proven fertile volunteers. Oxidative damage in seminal plasma was assessed by measuring the amount of 8-OHdG by indirect enzyme-linked immunosorbent assay. The data were also evaluated in terms of the smoking status and occupation stated by the patients and controls. Results: The fertile group had more seminal oxidative damage than the infertile group (487.33±209.42 vs 283.12±102.73, p=0.013). Comparing the non-smoker men, the smoking group's total sperm count was decreased (84.94 ± 24.09 vs 115.80 ± 25.46, p=0.036). Age, semen characteristics, daily cigarette consumption, and partner age did not differ between the infertile and control groups. Additionally, no difference was found between the smoker and non-smoker groups, and also among the occupation groups in terms of oxidative damage (p>0.05). No correlation was found between age, oxidative damage, smoking and semen parameters (p>0.05). Conclusion: The findings of this study could indicate that the level of seminal oxidative damage alone cannot be effective in infertile men. Also, as smoking or occupation, more factors should be considered for evaluating oxidative damage in infertile men. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Assessment of the transition of care from pediatric to adult rheumatology in a tertiary center

Author

Yıldız, Amra Adrovic, Ugurlu, Serdal; Ayla, Ali Yagiz; Besiroglu, Helin Idil; Azman, Feyza Nur; Egeli, Bugra; Eren, Hatice; Durucan, Ibrahim; Alkan, Arif; Ozturk, Sila; Ergun, Sercan; Barut, Kenan; Haslak, Fatih; Sahin, Sezgin; Yildiz, Mehmet; Ozdogan, Huri; Kasapcopur, Ozgur, Koç University Hospital, Yıldız, Amra Adrovic, Ugurlu, Serdal; Ayla, Ali Yagiz; Besiroglu, Helin Idil; Azman, Feyza Nur; Egeli, Bugra; Eren, Hatice; Durucan, Ibrahim; Alkan, Arif; Ozturk, Sila; Ergun, Sercan; Barut, Kenan; Haslak, Fatih; Sahin, Sezgin; Yildiz, Mehmet; Ozdogan, Huri; Kasapcopur, Ozgur, and Koç University Hospital

Abstract

NA

Published
2023

22. STRIKING NOVEL MULTI- MISMUTATIONS ON GNAS1, FGF23 AND FGFR3 GENES IN CKD WITH SECONDARY HYPERPARATHYROIDISM(SH) . SAGLIKER SYNDROME(SS) . SS IS A COMBINATION -COMPULSION OF BONE DISPLASIAS-HEREDITARY OSTEODYSTROPHIES AND SH AND CKD

Author

Sagliker, Yahya, Demirhan, Osman, Arslan, Ahmet, Akbal, Eylul, Ergun, Sercan, Bayraktar, Recep, Sagliker, Hasan Sabit, and Çukurova Üniversitesi

Abstract

56th Congress of the European-Renal-Association (ERA)-European-Dialysis-and-Transplant-Association (EDTA) - Burden, Access and Disparities in Kidney Disease -- JUN 13-16, 2019 -- Budapest, HUNGARY WOS: 000495412900557 … European Dialysis & Transplant Assoc, European Renal Assoc

Published
2019

24. Significance of miR-15a-5p and CNKSR3 as Novel Prognostic Biomarkers in Non-Small Cell Lung Cancer

Author

Ergun, Sercan, Güney, Serkan, Temiz, Ebru, Petrović, Nina, Gunes, Sezgin, Ergun, Sercan, Güney, Serkan, Temiz, Ebru, Petrović, Nina, and Gunes, Sezgin

Abstract

Background: In recent years, targeted cancer treatment methods at various molecular levels have been developed for Non-Small Cell Lung Cancer (NSCLC), one of two major subtypes of lung cancer. miRNAbased clinical trials are currently the preferred targeted therapeutic strategy. Also, ceRNAs (competing endogenous RNA) would be the newest and the most effective approach to uncover novel interactions between mRNAs and miRNAs in NSCLC carcinogenesis. There are many factors influencing the efficiency of a miRNA to suppress or silence translation of the target mRNA. The most effective event is the presence of other RNAs showing ceRNA activity. These RNAs contain binding sites for specific miRNAs and enable miRNAs to bind these pseudo targets, instead of the original binding sites on the target mRNA. Therefore, the mRNA of the target gene is less affected by this miRNA, while the amount of miRNA remains the same in the media. Method: For this project, we determined that five clinically important different oncogenes (PDL1, FGFR1, DDX3X, SLC1A5, FXR1) are involved in the pathogenesis of NSCLC. For this purpose, we transfected model NSCLC cell line, A549, with miRNAs (miR-150-5p, miR-15a-5p, miR-503-5p) targeting these oncogenes to investigate whether these oncogenes will be suppressed at the mRNA level and also how the suppression efficiency of these miRNA on the oncogenes will be affected by possible ceRNA (CNKSR3, POU2F1, HIPK2) activities. Results: miR-15a-5p was determined to have the most suppressive effect on the five genes and three potential ceRNAs (p<0.05). Furthermore, CNKSR3 was the ceRNA most affected by all three miRNAs (p<0.05). Conclusion: CNKSR3 was affected more than the oncogenes known to act on NSCLC and this might make it a stronger and novel marker for use in possible treatment regimens designed using miR-15a-5p silencing effect on oncogenes in NSCLC pathogenesis. According to the literature, this is the first study associating NSCLC with miR-15a-5p and

Published
2019

25. FP472STRIKING NOVEL MULTI- MISMUTATIONS ON GNAS1 , FGF23 AND FGFR3 GENES IN CKD WITH SECONDARY HYPERPARATHYROIDISM( SH ) . SAGLIKER SYNDROME( SS ) . SS IS A COMBINATION -COMPULSION OF BONE DISPLASIAS-HEREDITARY OSTEODYSTROPHIES AND SH AND CKD

Author

SAGLIKER, YAHYA, primary, Demirhan, Osman, additional, Arslan, Ahmet, additional, Akbal, Eylül, additional, Ergun, Sercan, additional, Bayraktar, Recep, additional, Sagliker, Hasan Sabit, additional, Gunesacar, Ramazan, additional, Ozkaynak, Sagliker Piril, additional, Paylar, Nuray, additional, and Idris, Emir, additional

Published
2019
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27. Levels of MicroRNA Heterogeneity in Cancer Biology

Author

Petrović, Nina, Ergun, Sercan, and Isenović, Esma R.

Abstract

MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression, involved in the silencing of messenger RNA (mRNA) translation. The importance of miRNA signatures in disease screening, prognosis, and progression of different tumor types and subtypes is increasing. miRNA expression levels change depending on numerous factors. In this review, we are describing the circumstances under which miRNA levels can change, these are named levels of heterogeneity of miRNAs. miRNAs can have oncogenic, tumor suppressive, or both roles depending on tumor type and target mRNA whose translation they silence. The expression levels of a single miRNA may vary across different cancer types and subtypes, indicating that a miRNA signature may be tissue specific. miRNA levels of expression also vary during disease formation and propagation, indicating the presence of a time profile for their expression. The complexity of the miRNA-mRNA interference network mirrors different genetic and epigenetic changes that influence miRNA and mRNA availability to each other, and hence, their binding ability. The potential role of miRNAs as biomarkers is two-fold; first, for monitoring of the phases of cancer pathogenesis, and second, to characterize the particular type/subtype of cancer. It is important that a particular miRNA should be characterized by examining as many types and subtypes of cancers as are available, as well as being extracted from different types of samples, in order to obtain a complete picture of its behavior and importance in the disease pathology.

Published
2017

29. FP400MULTIPLE GNAS1, FGF23, FGFR3 GENES’ STRİKİNG MUTATIONS IN CKD PATIENTS WITH SH. NEW BONE DISPLASIA-HEREDİTARY OSTEODISTROPHY AND UGLIFYING HUMAN FACE APPEARANCES. SAGLIKER SYNDROME(SS )

Author

Sagliker, Yahya, primary, Demirhan, Osman, additional, Arslan, Ahmet, additional, Sagliker, Hasan Sabit, additional, Bayraktar, Recep, additional, Dogan, Ekrem, additional, Sagliker Ozkaynak, Piril, additional, Paylar, Nuray, additional, Akbal, Eylül, additional, and Ergun, Sercan, additional

Published
2018
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31. NOVEL STRIKING MISMUTATIONS ON GNAS1, FGF23 AND FGFR3 GENES IN CKD WITH SECONDARY HYPERPARATHYROIDISM (SH) AND SAGLIKER SYNDROME (SS). SS IS ACOMBINATION-COMPULSION OF BONE DISPLASIAS-HEREDITARY OSTEODYSTROPHIES AND CKD

Author

Demirhan, Osman, Arslan, Ahmet, Sagliker, Yahya, Akbal, Eylul, Ergun, Sercan, Bayraktar, Recep, Sagliker, Hasan Sabit, and Çukurova Üniversitesi

Subjects
urologic and male genital diseases
Abstract

52nd Congress of the European-Renal-Association-European-Dialysis-and-Transplant-Assocation -- MAY 28-31, 2015 -- London, ENGLAND WOS: 000361215101406 … European Renal Assoc, European Dialysis & Transplant Assoc

Published
2015

34. SaO028NOVEL STRIKING MISMUTATIONS ON GNAS1, FGF23 AND FGFR3 GENES IN CKD WITH SECONDARY HYPERPARATHYROIDISM (SH) AND SAGLIKER SYNDROME (SS).SS IS A COMBINATION-COMPULSION OF BONE DISPLASIAS-HEREDITARY OSTEODYSTROPHIES AND CKD

Author

Demirhan, Osman, primary, Arslan, Ahmet, additional, Sagliker, Yahya, additional, Akbal, Eylül, additional, Ergun, Sercan, additional, Bayraktar, Recep, additional, Sagliker, Hasan Sabit, additional, Dogan, Ekrem, additional, Gunesacar, Ramazan, additional, Sagliker Ozkaynak, Piril, additional, and Paylar, Nuray, additional

Published
2015
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39. Novel Βeta (β)-Thalassemia Mutation in Turkish Children

Author

Ulasli, Mustafa, primary, Oztuzcu, Serdar, additional, Kirkbes, Sevil, additional, Bay, Ali, additional, Igci, Yusuf Ziya, additional, Bayraktar, Recep, additional, Igci, Mehri, additional, Ergun, Sercan, additional, Cakmak, Ecir Ali, additional, Aytekin, Elif, additional, and Arslan, Ahmet, additional

Published
2014
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41. Significance of miR-15a-5p and CNKSR3 as Novel Prognostic Biomarkers in Non-Small Cell Lung Cancer

Author

Ergun, Sercan, Güney, Serkan, Temiz, Ebru, Petrovic, Nina, and Gunes, Sezgin

Abstract

Background: In recent years, targeted cancer treatment methods at various molecular levels have been developed for Non-Small Cell Lung Cancer (NSCLC), one of two major subtypes of lung cancer. miRNAbased clinical trials are currently the preferred targeted therapeutic strategy. Also, ceRNAs (competing endogenous RNA) would be the newest and the most effective approach to uncover novel interactions between mRNAs and miRNAs in NSCLC carcinogenesis. There are many factors influencing the efficiency of a miRNA to suppress or silence translation of the target mRNA. The most effective event is the presence of other RNAs showing ceRNA activity. These RNAs contain binding sites for specific miRNAs and enable miRNAs to bind these pseudo targets, instead of the original binding sites on the target mRNA. Therefore, the mRNA of the target gene is less affected by this miRNA, while the amount of miRNA remains the same in the media. Method: For this project, we determined that five clinically important different oncogenes (PDL1, FGFR1, DDX3X, SLC1A5, FXR1 ) are involved in the pathogenesis of NSCLC. For this purpose, we transfected model NSCLC cell line, A549, with miRNAs (miR-150-5p, miR-15a-5p, miR-503-5p) targeting these oncogenes to investigate whether these oncogenes will be suppressed at the mRNA level and also how the suppression efficiency of these miRNA on the oncogenes will be affected by possible ceRNA (CNKSR3, POU2F1, HIPK2) activities. Results: miR-15a-5p was determined to have the most suppressive effect on the five genes and three potential ceRNAs (p<0.05). Furthermore, CNKSR3 was the ceRNA most affected by all three miRNAs (p<0.05). Conclusion: CNKSR3 was affected more than the oncogenes known to act on NSCLC and this might make it a stronger and novel marker for use in possible treatment regimens designed using miR-15a-5p silencing effect on oncogenes in NSCLC pathogenesis. According to the literature, this is the first study associating NSCLC with miR-15a-5p and CNKSR3.

Published
2018
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