1. EBV Reactivation and Disease in Allogeneic Hematopoietic Stem Cell Transplant (HSCT) Recipients and Its Impact on HSCT Outcomes.
- Author
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Law, Nancy, Logan, Cathy, and Taplitz, Randy
- Subjects
EBV-specific cytotoxic T-cells ,Epstein–Barr virus ,allogeneic transplant ,post-transplant lymphoproliferative disorder ,Hematopoietic Stem Cell Transplantation ,Humans ,Epstein-Barr Virus Infections ,Herpesvirus 4 ,Human ,Virus Activation ,Transplantation ,Homologous ,Lymphoproliferative Disorders ,Risk Factors - Abstract
The acquisition or reactivation of Epstein-Barr virus (EBV) after allogeneic Hematopoietic Stem Cell Transplant (HSCT) can be associated with complications including the development of post-transplant lymphoproliferative disorder (PTLD), which is associated with significant morbidity and mortality. A number of risk factors for PTLD have been defined, including T-cell depletion, and approaches to monitoring EBV, especially in high-risk patients, with the use of preemptive therapy upon viral activation have been described. Newer therapies for the preemption or treatment of PTLD, such as EBV-specific cytotoxic T-cells, hold promise. Further studies to help define risks, diagnosis, and treatment of EBV-related complications are needed in this at-risk population.
- Published
- 2024