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953 results on '"Epple, M."'

16. The relevance of biomaterials to the prevention and treatment of osteoporosis

Author

Arcos Navarrete, Daniel, Boccaccini, A. R., Bohner, M., Díez Pérez, A., Epple, M., Gómez Barrena, E., Herrera, A., Planell, J. A., Rodríguez Manas, L., Vallet Regí, María, Arcos Navarrete, Daniel, Boccaccini, A. R., Bohner, M., Díez Pérez, A., Epple, M., Gómez Barrena, E., Herrera, A., Planell, J. A., Rodríguez Manas, L., and Vallet Regí, María

Abstract

RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí), Osteoporosis is a worldwide disease with a very high prevalence in humans older than 50. The main clinical consequences are bone fractures, which often lead to patient disability or even death. A number of commercial biomaterials are currently used to treat osteoporotic bone fractures, but most of these have not been specifically designed for that purpose. Many drug- or cell-loaded biomaterials have been proposed in research laboratories, but very few have received approval for commercial use. In order to analyze this scenario and propose alternatives to overcome it, the Spanish and European Network of Excellence for the Prevention and Treatment of Osteoporotic Fractures, ‘‘Ageing’’, was created. This network integrates three communities, e.g. clinicians, materials scientists and industrial advisors, tackling the same problem from three different points of view. Keeping in mind the premise ‘‘living longer, living better’’, this commentary is the result of the thoughts, proposals and conclusions obtained after one year working in the framework of this network., Ministerio de Economia y Competitividad (MINECO), Depto. de Química en Ciencias Farmacéuticas, Fac. de Farmacia, TRUE, pub

Published
2023

19. A Novel Branched Copolymer-Containing Anticancer Drug for Targeted Therapy: In Vitro Research

Author

Yurchenko, A., Nikitina, N., Sokolova, V., Prylutska, S., Kuziv, Yu., Virych, P., Chumachenko, V., Kutsevol, N., Ponomarenko, S., Prylutskyy, Yu., and Epple, M.

Abstract

The viability of cancer cell lines (human transformed cervix epithelial cells, HeLa, and osteoblastic cell line from a C57BL/6 mouse calvaria, MC3T3, as models for cancer cells) was studied using MTT and live/dead assays after incubation with a branched copolymer dextran-graft polyacrylamide in anionic form (D-g-PAAan) as nanocarrier for drugs, doxorubicin (Dox), cisplatin (Cis), as well as their D-g-PAAan+Dox and D-g-PAAan+Cis mixtures, as a function of the concentration. Fourier transform infrared spectroscopy clearly indicates the complex formation of Cis and Dox with the D-g-PAAan branched copolymer. The size distribution of particles in aqueous solution and its stability were determined by dynamic light scattering. The in vitro uptake of studied particles into cancer cells was demonstrated by confocal laser scanning microscopy. It was found that D-g-PAAan+Dox particles in contrast to Dox alone showed higher toxicity towards cancer cells. This indicates the possibility of further preclinical studies of the water-soluble D-g-PAAan+Dox particles on animal tumor models in vivo as a promising anticancer agent.

Published
2024
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23. Untersuchungen zur Biokompatibilität und Interaktion von Silber-Nanopartikeln mit humanen mesenchymalen Stammzellen (hMSCs)

Author

Greulich, C., Kittler, S., Epple, M., Köller, M., Buhr, H. J., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Post, S., editor, Allgayer, H., editor, Bartsch, D. K., editor, Fries, H., editor, Ghadimi, B. M., editor, Habermann, J. K., editor, Kalthoff, H., editor, Schackert, H. K., editor, Bruns, C. J., editor, Duda, D. N., editor, Fändrich, F., editor, Heberer, M., editor, Nüssler, A. K., editor, Stark, G. B., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Heidecke, C. D., editor, Kalff, J. C., editor, Menger, M. D., editor, Schade, U. F., editor, Vollmar, B., editor, Bechstein, W. O., editor, Klar, E., editor, Klempnauer, J., editor, Minor, T., editor, Neuhaus, P., editor, Schmidt, J., editor, Langer, S., editor, Laschke, M. W., editor, Machens, H. G., editor, Steinau, H. U., editor, Südkamp, N., editor, Vogt, P., editor, Berger, D., editor, Klinge, U., editor, Schachtrupp, A., editor, Schilling, M. K., editor, Schumpelick, V., editor, Altendorf-Hofmann, A., editor, Bollschweiler, E., editor, Bruch, H. -P., editor, Lehnert, T., editor, Lorenz, W., editor, Neugebauer, E., editor, Ohmann, C., editor, Seiler, C. M., editor, Becker, H., editor, Betzler, M., editor, Bittner, R., editor, Broelsch, C., editor, Büchler, M. W., editor, Bumm, R., editor, Dralle, H., editor, Friess, H., editor, Frilling, A., editor, Germer, C. T., editor, Hopt, U., editor, Jonas, S., editor, Jost, J., editor, Markus, B., editor, Raab, H. R., editor, Reith, H. B., editor, Schlag, P. M., editor, Teichmann, W., editor, Uhl, W., editor, Wenisch, H., editor, and Zornig, C., editor

Published
2009
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45. Contributor contact details

Author

Boccaccini, A.R., primary, Ma, P.X., additional, Huang, J., additional, Best, S., additional, Wei, G., additional, Rahaman, M.N., additional, Miguez-Pacheco, V., additional, Misra, S.K., additional, Boccaccini, A.R., additional, Luz, G.M., additional, Mano, J.F., additional, Anderson, S.I., additional, Nettleship, I., additional, Mansbridge, J., additional, Davis, F., additional, Higson, S.P.J., additional, Luczynski, K., additional, Dejaco, A., additional, Hellmich, C., additional, Komlev, V., additional, Swieszkowski, W., additional, Lee, S.J., additional, Atala, A., additional, Chen, Q.Z., additional, Harding, S.E., additional, Rai, R., additional, Saito, A., additional, Wezel, F., additional, Southgate, J., additional, Kolar, M.K., additional, Kingham, P.J., additional, Ansari, T., additional, Gabe, S.M., additional, Klumpp, D., additional, Horch, R.E., additional, Beier, J.P., additional, Salih, V., additional, Bierwolf, J., additional, Pollok, J.-M., additional, Ghezzi, C.E., additional, Marelli, B., additional, Nazhat, S.N., additional, Sokolova, V., additional, Epple, M., additional, Mouriño, V., additional, Cattalini, J.P., additional, Li, W., additional, and Lucangioli, S., additional

Published
2014
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46. Two-Particle Quantum Interference and Bell’s Theorem

Author

Epple, M.

Subjects
High Energy Physics::Experiment
Abstract

Bell’s theorem is among the most challenging consequences of quantum mechanics. In this thesis, the connection between Bell’s theorem and quantum interference is investigated by asking the question, whether Bell’s theorem can be proven on the basis of two-particle quantum interference. In the first part of this thesis the meaning of quantum interference and Bell’s Theorem for the discussion about the interpretation of quantum mechanics is retraced. By considering three major branches of interpretations, the conceptual diculties, which are encountered in the face of quantum interference and Bell’s theorem, are discussed. In addition, an epistemological argument for the inherent indeterminism of certain quantum mechanical phenomena is presented. In the second part of this thesis a two-particle quantum interference thought experiment is developed and it is shown that Bell’s theorem can be proven from two-particle quantum interference, if certain quantum mechanical phenomena in the experiment are inherently indeterministic.

Published
2021

47. Functionalization of additive-manufactured Ti6Al4V scaffolds with poly(allylamine hydrochloride)/poly(styrene sulfonate) bilayer microcapsule system containing dexamethasone

Author

Chudinova, E., Koptyug, Andrey, Mukhortova, Y., Pryadko, A., Volkova, A., Ivanov, A., Plotnikov, E., Khan, Y., Epple, M., Sokolova, V., Prymak, O., Douglas, T., Surmenev, R., Surmeneva, M., Chudinova, E., Koptyug, Andrey, Mukhortova, Y., Pryadko, A., Volkova, A., Ivanov, A., Plotnikov, E., Khan, Y., Epple, M., Sokolova, V., Prymak, O., Douglas, T., Surmenev, R., and Surmeneva, M.

Abstract

Porous titanium alloy Ti6Al4V scaffolds manufactured via electron beam melting (EBM®) reveal broad prospects for applications in bone tissue engineering. However, local inflammation and even implant failure may occur while placing an implant into the body. Thus, the application of drug carriers to the surface of a metallic implant can provide treatment at the inflammation site. In this study, we propose to use polyelectrolyte (PE) microcapsules formed by layer-by-layer (LbL) synthesis loaded with both porous calcium carbonate (CaCO3) microparticles and the anti-inflammatory drug dexamethasone (DEX) to functionalize implant surfaces and achieve controlled drug release. Scanning electron microscopy indicated that the CaCO3 microparticles coated with PE bilayers loaded with DEX had a spherical shape with a diameter of 2.3 ± 0.2 μm and that the entire scaffold surface was evenly coated with the microcapsules. UV spectroscopy showed that LbL synthesis allows the manufacturing of microcapsules with 40% DEX. According to high performance liquid chromatography (HPLC) analysis, 80% of the drug was released within 24 h from the capsules consisting of three bilayers of polystyrene sulfonate (PSS) and poly(allylamine)hydrochloride (PAH). The prepared scaffolds functionalized with CaCO3 microparticles loaded with DEX and coated with PE bilayers showed hydrophilic surface properties with a water contact angle below 5°. Mouse embryonic fibroblast cells were seeded on Ti6Al4V scaffolds with and without LbL surface modification. The surface modification with LbL PE microcapsules with CaCO3 core affected cell morphology in vitro. The results confirmed that DEX had no toxic effect and did not prevent cell adhesion and spreading, thus no cytotoxic effect was observed, which will be further studied in vivo.

Published
2021
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