1. PERK leads a hub dictating pancreatic β cell homoeostasis.
- Author
-
Kefalas G and Larose L
- Subjects
- Activating Transcription Factor 4 genetics, Activating Transcription Factor 4 immunology, Adult, Animals, Diabetes Mellitus, Experimental enzymology, Diabetes Mellitus, Experimental genetics, Diabetes Mellitus, Experimental immunology, Diabetes Mellitus, Experimental pathology, Diabetes Mellitus, Type 1 enzymology, Diabetes Mellitus, Type 1 immunology, Diabetes Mellitus, Type 1 pathology, Diabetes Mellitus, Type 2 enzymology, Diabetes Mellitus, Type 2 immunology, Diabetes Mellitus, Type 2 pathology, Epiphyses enzymology, Epiphyses immunology, Epiphyses pathology, Eukaryotic Initiation Factor-2 immunology, Gene Expression Regulation, Developmental, Homeostasis immunology, Humans, Infant, Newborn, Insulin-Secreting Cells immunology, Insulin-Secreting Cells pathology, NF-E2-Related Factor 2 genetics, NF-E2-Related Factor 2 immunology, Osteochondrodysplasias enzymology, Osteochondrodysplasias immunology, Osteochondrodysplasias pathology, Signal Transduction, eIF-2 Kinase deficiency, eIF-2 Kinase immunology, Diabetes Mellitus, Type 1 genetics, Diabetes Mellitus, Type 2 genetics, Epiphyses abnormalities, Eukaryotic Initiation Factor-2 genetics, Homeostasis genetics, Insulin-Secreting Cells enzymology, Osteochondrodysplasias genetics, eIF-2 Kinase genetics
- Abstract
In humans, the pathogenesis of diabetes is characterised by two major pancreatic β cell defects: a reduction in β cell mass and the failure of β cells to produce enough insulin. Over the past two decades, multiple studies involving cell cultures, animal models and human subjects have established the importance of the protein kinase RNA-like endoplasmic reticulum kinase (PERK) in the adaptive functional capacity of pancreatic β cells during embryonic development and into adulthood. In this review, we will highlight major findings identifying PERK as a crucial player in β cell physiology and in diabetes., (© 2017 Société Française des Microscopies and Société de Biologie Cellulaire de France. Published by John Wiley & Sons Ltd.)
- Published
- 2018
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