335 results on '"Epignathus"'
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2. Perinatal management for fetal oral epignathus with duplication of the pituitary gland (DPG)‐plus syndrome: A case report and literature review.
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Khwankaew, Noppasin, Sawaddisan, Rapphon, Siripruekpong, Sirikarn, Leelasawatsuk, Peesit, Praditaukrit, Manapat, and Tanaanantarak, Pattama
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- *
LITERATURE reviews , *PITUITARY gland , *SOFT palate , *CENTRAL nervous system , *HARD palate - Abstract
The prenatal diagnosis of epignathus presents a unique challenge for physicians. Differential diagnosis is usually based on the anatomic location of the tumor. Typical prenatal ultrasound characteristics of epignathus include a mixed solid and cystic lesion with vascularity in the solid component, originating from the hard or soft palate, and it is often associated with other anomalies such as craniofacial clefts or trans‐sphenoidal intracranial extension. Herein, we present a case of prenatal diagnosis of epignathus with rare ultrasonographic findings, prenatal management requiring collaborative efforts of a multidisciplinary team, and a well‐planned innovative ex utero intrapartum treatment procedure. In addition, this report highlights the evolving postnatal diagnosis of the rare developmental anomaly, duplication of the pituitary gland‐plus syndrome, which includes various midline craniofacial, central nervous system, spinal, and endocrine abnormalities. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Case Report: A Giant Epignathus with a Well-Developed Skeleton of Head and Neck.
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Goto, Shintaro, Nakazawa, Atsuko, Yoshizawa, Tadashi, Aoki, Masahiko, Hirabayashi, Takeshi, Seino, Hiroko, Morohashi, Satoko, and Kijima, Hiroshi
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GERM cell tumors , *SKELETON , *NECK , *HEAD , *SALIVARY glands , *THYROID gland - Abstract
Epignathus is an extremely rare teratoma found in the oral cavity or oropharyngeal region of newborns, whose pathogenesis is poorly understood. We describe a giant epignathus arising from the oropharynx in a newborn. The giant tumor completely obstructed the airway of the newborn resulting in death. Histological and radiological examination of the tumor reveals the presence of a remarkably well-developed skeleton of the head and neck. A row of teeth, the axis and atlas, thyroid and salivary glands, trachea, and cerebral tissue are all detected within the tumor. These findings suggest that the epignathus is fetus-in-fetu which is considered a type 0 germ cell tumor in accordance with current literature. [ABSTRACT FROM AUTHOR]
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- 2023
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4. Case report and review of the literature: rare fetus-in-fetu presenting as oropharyngeal epignathus
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Daniel Runggaldier, Michael Reinehr, Hergen Friedrich, Georg Henze, Dominic Good, and Claudine Gysin
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heteropagus ,asymmetric twin ,fetus in fetu (FIF) ,neonate airway ,epignathus ,Surgery ,RD1-811 - Abstract
An epignathus is caused by a continuous spectrum of masses of the oral cavity or oropharynx ranging in its entity from mature teratoma to the exceedingly rare fetus-in-fetu. Due to its location, regardless of the entity, the occurrence of an epignathus is frequently associated with life threatening airway obstruction. Here we demonstrate a case of a fetus-in-fetu presenting as an epignatus. We describe its successful management and review the available literature. Early diagnosis and knowledge of the preoperative workup are essential to enable a multidisciplinary management. Once the airway is secured, surgical excision is the treatment of choice often resulting in a good clinical outcome and prognosis.
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- 2023
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5. Congenital Epignathus and Extra-Uterine Intrapartum Treatment Procedure
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Dirican, Aylin Önder
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- 2023
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6. Epignatus: manejo quirúrgico y multidisciplinar. Un caso clínico.
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Sánchez Montañés, Borja, Munill Ferrer, Montserrat, Ruíz Casas, Jennifer, and Bescòs Atín, María Socorro
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CLEFT palate ,FETAL development ,PRENATAL diagnosis ,DEATH rate ,MICROGNATHIA - Abstract
Copyright of Revista Española de Cirugía Oral y Maxilofacial is the property of Sociedad Espanola de Cirugia Oral y Maxilofacial (SECOM) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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7. Congenital epignathus associated with a cleft palate: a case report
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Fabrice Lele Mutombo, Jason Nzanzu Kikuhe, Noé Kasereka Mwanamolo, Marc H. Erickson, Neil Wetzig, and Médard Kabuyaya Kakule
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Epignathus ,Teratoma ,Cleft palate ,Airway obstruction ,Medicine - Abstract
Abstract Background Epignathus is a rare, benign, congenital teratoma of the hard palate with an estimated incidence of 1 in 200,000 live births. Epignathus frequently leads to a high mortality (80–100%) due to airway obstruction in the neonatal period. Case presentation We report a case of successful management of a rare oropharyngeal teratoma in a African newborn girl who was referred to our institute with a large protruding intraoral mass, combined with cleft palate, causing some respiratory compromise. The palatal mass was removed on the fifth day after birth, and a palatoplasty performed on day 30. Conclusion Epignathus is a life-threatening condition at the time of delivery. Appropriate management begins with securing the airway, followed by complete resection of the tumor.
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- 2021
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8. Congenital orofacial teratoma in a 22-week foetus.
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HAMIDI, Lizawati Rasul, SAAID, Rahmah, SAMBERKAR, Prashant Naresh, Yin Ping WONG, and Geok Chin TAN
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This article, published in the Malaysian Journal of Pathology, reports on a case of congenital orofacial teratoma, also known as epignathus, in a 22-week-old fetus. The mother, a 34-year-old woman, presented for a routine examination and an ultrasound revealed a solid-cystic facial tumor in the fetus. The pregnancy was terminated and the stillborn fetus was examined, revealing a large tumor protruding from the oral cavity and an intracranial tumor. Microscopic examination showed immature teratomas in both tumors. Congenital orofacial teratoma is rare and can be associated with malformations such as cleft palate. Early detection is important for intervention to prevent airway obstruction. [Extracted from the article]
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- 2024
9. Giant Epignathus (Teratoma of Palatine Tonsil): A Case Report
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Fuat Aydemir, Mert Mutaf, and Mehmet Akif Eryılmaz
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epignathus ,teratoma ,fetal anomaly ,palatine tonsil ,pediatric otorhinolaryngology ,case report ,Otorhinolaryngology ,RF1-547 - Abstract
Teratomas are benign tumours containing tissues derived from ectoderm, endoderm and mesoderm Epignathus is a rare congenital teratoma and originates from oropharyngeal region. We present a case of giant epignathus arising from tonsillar region in a neonate. A male neonate that was born with a 38-week cesarean section presented with a pedunculated mass from left tonsilla palatina and protruding outside the mouth. The patient did not have any airway problem. Magnetic resonance imaging and computed tomography scan showed no intracranial extension. The patient was operated on the postpartum 3rd day and the mass was excised successfully. After histopathological examination, mature teratoma was diagnosed. During post-operative 6 months control visit, there was no recurrence. Epignathus is a rare congenital oropharyngeal teratoma, it should be diagnosed in the fetus as early as possible. Teratomas of the tonsilla palatina are extremely rare. In such cases, the mass may cause airway obstruction and feeding difficulties so complete resection is curative in most cases during the early neonatal period.
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- 2021
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10. An Unusual Lesion of Epignathus with Duplicate Tongue and Ranula in a Neonate.
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Eswaran, Sudhagar, Kumar, Poornima, and Kumar, Sunil
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RANULA , *NEWBORN infants , *SYMPTOMS , *TONGUE , *PRENATAL diagnosis - Abstract
We report a rare case of epignathus (oropharyngeal teratoma) in a neonate, who presented with a midline mass covered with skin and multiple hairs protruding from the Palate and associated with bifid tongue and ranula. With the characteristic presentation, diagnosis of oro/oropharyngeal teratoma was made and a massive internet search revealed very few reported cases of "epignathus". It is unfortunate that the survival of such neonates is only moderate. Prenatal scans and follow up in an institution can prepare the multidisciplinary team to save the child. EXIT procedure to excise the mass or secure the airway, with future repair of the palate is the treatment option available. This case report emphasizes the rare clinical presentation of the disease and the prenatal diagnosis of such a condition can help in prompt decision making and management. [ABSTRACT FROM AUTHOR]
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- 2022
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11. Unusual Cause of Neonatal Stertor.
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Amalanathan, Sophia, Mathews, Suma Susan, and Rupa, V.
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PERINATAL death , *TERATOMA , *RESPIRATORY obstructions , *TUMORS - Abstract
We report a case of neonatal respiratory distress caused by an epignathus. This rare tumour, arising from the basisphenoid and protruding from the mouth, is associated with high perinatal mortality. We highlight unique clinico-radiological findings and multidisciplinary approach for a successful outcome. We review oropharyngeal teratomas reported in the literature with current management approaches. [ABSTRACT FROM AUTHOR]
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- 2022
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12. Congenital epignathus associated with a cleft palate: a case report.
- Author
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Lele Mutombo, Fabrice, Nzanzu Kikuhe, Jason, Kasereka Mwanamolo, Noé, Erickson, Marc H., Wetzig, Neil, and Kabuyaya Kakule, Médard
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CLEFT palate , *RESPIRATORY obstructions , *HARD palate , *TERATOMA , *VELOPHARYNGEAL insufficiency ,TUMOR surgery - Abstract
Background: Epignathus is a rare, benign, congenital teratoma of the hard palate with an estimated incidence of 1 in 200,000 live births. Epignathus frequently leads to a high mortality (80-100%) due to airway obstruction in the neonatal period.Case Presentation: We report a case of successful management of a rare oropharyngeal teratoma in a African newborn girl who was referred to our institute with a large protruding intraoral mass, combined with cleft palate, causing some respiratory compromise. The palatal mass was removed on the fifth day after birth, and a palatoplasty performed on day 30.Conclusion: Epignathus is a life-threatening condition at the time of delivery. Appropriate management begins with securing the airway, followed by complete resection of the tumor. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
13. Giant Epignathus (Teratoma of Palatine Tonsil): A Case Report.
- Author
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Aydemir, Fuat, Mutaf, Mert, and Eryılmaz, Mehmet Akif
- Subjects
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BENIGN tumors , *COMPUTED tomography , *TERATOMA , *TONSILS , *MAGNETIC resonance imaging , *GERM cell tumors - Abstract
Teratomas are benign tumours containing tissues derived from ectoderm, endoderm and mesoderm Epignathus is a rare congenital teratoma and originates from oropharyngeal region. We present a case of giant epignathus arising from tonsillar region in a neonate. A male neonate that was born with a 38-week cesarean section presented with a pedunculated mass from left tonsilla palatina and protruding outside the mouth. The patient did not have any airway problem. Magnetic resonance imaging and computed tomography scan showed no intracranial extension. The patient was operated on the postpartum 3rd day and the mass was excised successfully. After histopathological examination, mature teratoma was diagnosed. During post-operative 6 months control visit, there was no recurrence. Epignathus is a rare congenital oropharyngeal teratoma, it should be diagnosed in the fetus as early as possible. Teratomas of the tonsilla palatina are extremely rare. In such cases, the mass may cause airway obstruction and feeding difficulties so complete resection is curative in most cases during the early neonatal period. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
14. Airway management with Airtraq in a neonate with Epignathus. A case report
- Author
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Farah Nasreen, Mohit Prakash, Atif Khalid, and Danish Hushain
- Subjects
airway management ,epignathus ,neonate ,Anesthesiology ,RD78.3-87.3 - Abstract
Presence of intraoral pathology especially in neonates poses a great challenge during airway management. Epignathus is a rare form of teratoid tumour that arises from the oropharyngeal region. We hereby report a case of a 7-day-old neonate who presented with feeding difficulty secondary to swelling arising from the hard palate. Surgical excision was decided to overcome feeding difficulty and to enable the child to thrive better. In view of anticipated difficult airway, the child was induced with sevoflurane, maintaining spontaneous breathing and intubated with Airtraq optical laryngoscope size 0. The further intraoperative and postoperative period was uneventful.
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- 2020
- Full Text
- View/download PDF
15. An autopsy case of epignathus (immature teratoma of the soft palate) with intracranial extension but without brain invasion: case report and literature review
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Mari Kirishima, Sohsuke Yamada, Mitsuhisa Shinya, Shun Onishi, Yuko Goto, Ikumi Kitazono, Tsubasa Hiraki, Michiyo Higashi, Akira I. Hida, and Akihide Tanimoto
- Subjects
Epignathus ,Intracranial extension ,Immature teratoma ,Hypoxia ,Pathology ,RB1-214 - Abstract
Abstract Background Epignathus is a rare congenital orofacial teratoma infrequently associated with intracranial extension. Intracranial extension of an epignathus indicates a poor prognosis; however, only a small number of such cases have been reported. While there have been some studies reporting cases of epignathus expanding directly into the cranium, others have reported no communication between an epignathus and an intracranial tumor. Case presentation A fetus at gestational week 27 was suspected of having an epignathus with intracranial tumor as shown by ultrasonographic and magnetic resonance imaging. The fetus was stillborn and an autopsy was performed. An epignathus measuring 12 × 6 × 6 cm and weighing 270 g protruded from the mouth, with its base on the soft palate. An intracranial tumor weighing 14 g was located at the middle intracranial fossa and connected to the epignathus through the right side of the sella turcica. The intracranial tumor was encapsulated, and there was no invasion into the brain. Histologically, both the epignathus and intracranial tumor were immature teratomas, with neural and pulmonary components that were especially immature as compared to those of the internal organs and brain tissues of the fetus. Conclusion There have been several reports of epignathus and intracranial tumors that did not communicate; therefore, careful evaluation is needed when a fetus is suspected of having an epignathus extending into an intracranial lesion. Our case supports the findings that an epignathus can directly expand into the cranium. Moreover, this is a rare case of an epignathus in which the intracranial lesion was encapsulated and did not invade the brain. These rare but important findings will provide additional, potential therapeutic strategies for gynecologists, neurosurgeons, and pathologists.
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- 2018
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16. Tongue shaped oropharyngeal teratoma with cleft palate in a neonate: A case report
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Samiul Hasan, Nadia Afroz, and Jiaul Reza
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Oropharyngeal teratoma ,Cleft palate ,Neonatal tumor ,Epignathus ,Pediatrics ,RJ1-570 ,Surgery ,RD1-811 - Abstract
Background: Atypical presentation of an atypical abnormality makes the diagnosis challenging. Oropharyngeal teratoma (epignathus) is a rare, potentially life-threatening neonatal tumor. Its atypical presentation may cause a delay in diagnosis and increase morbidity and mortality. Case presentation: A newborn girl with oropharyngeal teratoma and cleft palate presented with feeding difficulty. The airway was patent. The tumor was tongue-shaped, smooth-walled, displacing the native tongue, and prevented the fusion of two palatine halves resulting in cleft palate. On the 4th day of life, complete excision was done transorally. Histopathology revealed a mature teratoma. There was no sign of recurrence at three months of follow-up. Conclusion: Presentation of the oropharyngeal teratoma varies according to its site, size, and extension. Timely diagnosis is essential to avoid life-threatening respiratory obstruction. Complete excision of the mass is usually associated with a good prognosis.
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- 2021
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17. A Case Report of a Massive Epignathus.
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Naleini, Farhad, Farshchian, Nazanin, Mehrbakhsh, Mahmood, and Kamangar, Parisa Bahrami
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PROGNOSIS , *EPIBLAST , *TERATOMA , *PRENATAL diagnosis , *PREGNANT women - Abstract
Epignathus is a rare congenital orofacial teratoma. Teratomas are tumors that originate from all three germs cell layers. Tumor size is an important prognostic factor, and we describe the case of massive epignathus identified by sonography at 25 weeks. Our case was a 35-year-old pregnant woman that was subjected to a routine ultrasound at 25 weeks of gestation, and epignathus was diagnosed. Labor pain started in the 28th week of the pregnancy, so the dead fetus was aborted, and curettage was conducted. A pathologic sample was sent to the laboratory, and benign teratoma was diagnosed. Because fetal epignathus has a wide range of outcomes, early prenatal diagnosis is essential for optimal management. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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18. MRI of the Fetal Head and Neck
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Lall, Neil U., Meyers, Mariana L., Mirsky, David M., and Masselli, Gabriele, editor
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- 2016
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19. Operative Surgical Management of Fetuses with CHAOS: Management at Delivery
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Laje, Pablo, Hedrick, Holly L., Lioy, Janet, editor, and Sobol, Steven E., editor
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- 2015
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20. Prenatal diagnosis and immediate successful management of isolated fetal epignathus.
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ElSherbiny Hamed, Mohamed, El-Din, Mohamed, Abdelazim, Ibrahim, Shikanova, Svetlana, Karimova, Bakyt, and Kanshaiym, Sakiyeva
- Abstract
Epignathus or enigmatic teratoma is rare congenital tumor, arising from the sphenoid region of the palate or pharynx. A 30-year-old pregnant woman presented at 34 weeks + 2 days' gestation with a well-defined solid mass measuring 6.47 cm × 5.7 cm arising from the fetal oral cavity. The color flow mapping showed that the mass was well vascularized, especially in its center, and its blood supply was originated from the fetal oral cavity. The newborn has no chromosomal abnormalities or other associated anomalies and/or intracranial extension immediately and successfully managed after delivery to highlight the importance of prenatal diagnosis and the importance of multidisciplinary team management. [ABSTRACT FROM AUTHOR]
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- 2019
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21. Clinical outcomes of ex utero intrapartum treatment for fetal airway obstruction.
- Author
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Masahata, Kazunori, Soh, Hideki, Tachibana, Kazuya, Sasahara, Jun, Hirose, Masayuki, Yamanishi, Tadashi, Ibuka, Souji, Okuyama, Hiroomi, and Usui, Noriaki
- Subjects
- *
THERAPEUTICS , *TRACHEOTOMY , *CLINICAL indications , *TRACHEA intubation , *DISEASE complications , *TERATOMA - Abstract
Purpose: The aim of this study was to evaluate the indications and the clinical outcomes of the fetuses managed with ex utero intrapartum treatment (EXIT) procedures.Methods: We retrospectively reviewed the medical records of all fetuses who underwent EXIT procedures between 2003 and 2018.Results: EXIT procedures were performed in nine cases. The prenatal diagnosis of the neonates was congenital high airway obstruction syndrome in four cases, the neck masse in five cases. Although the airway management under the EXIT procedure was successful in eight cases, the airway management failed in one case. During the EXIT procedures, the airway was managed by endotracheal intubation in two cases, whereas six cases underwent tracheostomy. Six cases with fetal airway obstruction survived to discharge, whereas three cases died due to airway management failure or complications of the underlying disease. A case with a cervical teratoma underwent tumor resection the day after birth due to rapid enlargement of the neck mass. Long-term survival was achieved in five cases.Conclusions: We concluded that the EXIT procedure was effective and could be performed safely in the airway management of fetuses with suspected airway obstruction. The treatment strategy for the neck masses should be planned before birth. [ABSTRACT FROM AUTHOR]- Published
- 2019
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22. Neonatal epignathus in the oral and pharyngeal regions: A case report.
- Author
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Sugiyama, Madoka, Kanke, Kosuke, Suenaga, Hideyuki, Isojima, Tsuyoshi, Fujishiro, Jun, and Hoshi, Kazuto
- Abstract
Congenital teratoma that arises in the oropharyngeal region is called epignathus. Here, we report a case in which large epignathus extending from the pharynx to the oral cavity was resected. A female fetus was found to have a mass extending on her face to the pharyngeal region during a sonographic examination performed at 33 weeks' gestation. On the 9th day after birth, the tumor extending from the left nostril (10 cm) was excised by the pediatric surgeons. The residual tumor protruded from the oral cavity day by day. Pediatric and oral surgeons resected the tumor (14.5 cm). A bifid uvula was noted and submucosal cleft palate was suspected. No recurrence has been seen after 4 years' follow‐up. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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23. The fatal fetal tumor: a geneticist's perspective.
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Arora, Veronica, Bijarnia Mahay, Sunita, Rao, Seema, Dimri, Nandita, Manocha, Anisha, Mansukhani, Chandra, Mishra, Ranjana, Gupta, Seema, Dua Puri, Ratna, and Verma, I. C.
- Subjects
- *
ABORTION , *GENETICISTS , *COUPLES therapy , *EMBRYOLOGY , *GENETIC testing , *TERATOMA , *FETAL diseases , *CONJOINED twins , *FETAL ultrasonic imaging - Abstract
Epignathus is an extremely rare oral teratoma which leads to high mortality in the early neonatal period. Various theories have been put forward for the genesis of such a tumor, though none is completely convincing. A genetic basis is not well established for the tumor. Microdeletions/duplications, as well as single gene disorders, have been known to cause epignathus, all with additional malformations. Evidence of single gene involvement in an isolated epignathus is lacking. We present a case of a 19-week-fetus with oro-pharyngeal teratoma detected on the level II ultrasound. The couple was counseled regarding the grave prognosis of the fetal condition following which they opted for termination of pregnancy and fetal autopsy. The autopsy revealed fetus-like body attached to the tumor. Genetic testing including a whole genome microarray did not reveal any significant variant. An explanation for the fetus-like body maybe a common origin of the teratoma and the additional fetus-like bodies due to an erroneous process of early embryonic development. Another possibility is of an acardiacus acranius twin masquerading as a fetus-like body. Thus, we conclude that in the absence of an associated malformation, an epignathus is unlikely to have a genetic etiology. This study highlights the importance of performing a fetal autopsy as a part of deep phenotyping to ascertain the etiology, as it identified additional fetal-like body which was not detected on the antenatal ultrasound. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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24. Case report: Congenital palatal teratoma (epignathus) leading to neonatal airway obstruction.
- Author
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Nguyen, Pham Tu Anh, Lavisha, Punjabi, Lynn, Koh Huiting, and Jitendrakumar, Vora Shrenik
- Abstract
Congenital teratomas arising from the oropharynx, also known as epignathus, are exceedingly rare tumours occurring in 1:35,000–200,000 live births. Although histologically benign, these tumours are often difficult to diagnose antenatally and can cause life-threatening airway obstruction in the newborn. We present a case of a full-term female infant presenting at birth with respiratory distress and stridor. Clinical examination and magnetic resonance imaging showed a large multilobulated nasopharyngeal mass causing severe airway compromise. The infant underwent excision biopsy with partial debulking of the tumour surrounding the airway, and was successfully extubated thereafter to room air. Histopathological examination confirmed the diagnosis of mature teratoma. The pathophysiology of epignathus is thought to be aberrant proliferation of pluripotent cells in the notochord during early embryogenesis. Antenatally, elevated maternal alpha-fetoprotein or polyhydramnios may be clue to diagnosis. The mainstay of treatment is airway clearance with surgical resection, which can be curative or at least minimizes the risk of malignancy. This case highlights the importance of early recognition and multidisciplinary management of the neonatal airway, in order to improve outcome. • Congenital oropharyngeal teratomas are benign but can be life-threatening. • Early airway stabilization and surgical resection are the mainstay of treatment. • Multidisciplinary follow-up is important to support feeding and development. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
25. Prenatal Diagnosis of Fetal Immature Oropharyngeal Teratoma in the First Trimester: A Case Report
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Banu, Shaheen, Mohamad, Hafiz, Dubey, Aditi, Elango, Nithya, and Vikraman, Seneesh Kumar
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- 2021
- Full Text
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26. Surgical management of palatal teratoma (epignathus) with the use of virtual reconstruction and 3D models: a case report and literature review
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Mayela Guadalupe Salazar-Lara, Pablo Patricio Flores García, Pablo J Moreno-Peña, Yanko Castro-Govea, Victor Hugo Cervantes-Kardasch, Cynthia M. Gonzalez-Cantu, and Fernando Montes-Tapia
- Subjects
medicine.medical_specialty ,RD1-811 ,business.industry ,Pharynx ,3d model ,medicine.disease ,Epignathus ,3d reconstruction computed tomography ,improved surgical approach ,Surgery ,Plastic surgery ,medicine.anatomical_structure ,Pediatric surgery ,Virtual reconstruction ,Medicine ,Teratoma ,pediatric plastic surgery ,Hypertelorism ,medicine.symptom ,teratoma ,business - Abstract
Epignathus is a rare congenital orofacial teratoma that arises from the sphenoid region of the palate or the pharynx. It occurs in approximately 1:35,000 to 1:200,000 live births representing 2% to 9% of all teratomas. We present the case of a newborn of 39.4 weeks of gestation with a tumor that occupied the entire oral cavity. The patient was delivered by cesarean section. Oral resection was managed by pediatric surgery. Plastic surgery used virtual 3-dimensional models to establish the extension, and depth of the tumor. Bloc resection and reconstruction of the epignathus were performed. The mass was diagnosed as a mature teratoma associated with cleft lip and palate, nasoethmoidal meningocele that conditions hypertelorism, and a pseudomacrostoma. Tridimensional technology was applied to plan the surgical intervention. It contributed to a better understanding of the relationships between the tumor and the adjacent structures. This optimized the surgical approach and outcome.
- Published
- 2021
27. Congenital epignathus associated with a cleft palate: a case report
- Author
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Jason Nzanzu Kikuhe, Médard Kabuyaya Kakule, Marc H. Erickson, Fabrice Lele Mutombo, Neil Wetzig, and Noé Kasereka Mwanamolo
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0301 basic medicine ,Palate, Hard ,Epignathus ,Pediatrics ,medicine.medical_specialty ,030106 microbiology ,Case Report ,03 medical and health sciences ,0302 clinical medicine ,Surgical oncology ,medicine ,Humans ,business.industry ,Incidence (epidemiology) ,Infant, Newborn ,Teratoma ,General Medicine ,Airway obstruction ,Plastic Surgery Procedures ,medicine.disease ,medicine.anatomical_structure ,Cleft palate ,030220 oncology & carcinogenesis ,Medicine ,Female ,Mouth Neoplasms ,Hard palate ,business - Abstract
Background Epignathus is a rare, benign, congenital teratoma of the hard palate with an estimated incidence of 1 in 200,000 live births. Epignathus frequently leads to a high mortality (80–100%) due to airway obstruction in the neonatal period. Case presentation We report a case of successful management of a rare oropharyngeal teratoma in a African newborn girl who was referred to our institute with a large protruding intraoral mass, combined with cleft palate, causing some respiratory compromise. The palatal mass was removed on the fifth day after birth, and a palatoplasty performed on day 30. Conclusion Epignathus is a life-threatening condition at the time of delivery. Appropriate management begins with securing the airway, followed by complete resection of the tumor.
- Published
- 2021
28. Airway management with Airtraq in a neonate with Epignathus. A case report.
- Author
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Nasreen, Farah, Prakash, Mohit, Khalid, Atif, and Hushain, Danish
- Subjects
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NEWBORN infants , *HARD palate , *AIRWAY (Anatomy) , *POSTOPERATIVE period , *SURGICAL excision , *INGESTION disorders - Abstract
Presence of intraoral pathology especially in neonates poses a great challenge during airway management. Epignathus is a rare form of teratoid tumour that arises from the oropharyngeal region. We hereby report a case of a 7-day-old neonate who presented with feeding difficulty secondary to swelling arising from the hard palate. Surgical excision was decided to overcome feeding difficulty and to enable the child to thrive better. In view of anticipated difficult airway, the child was induced with sevoflurane, maintaining spontaneous breathing and intubated with Airtraq optical laryngoscope size 0. The further intraoperative and postoperative period was uneventful. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
29. Epignathus -- Oropharyngeal Teratoma in a Newborn.
- Author
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GÜNEY, Doğuş, BOSTANCI, Süleyman Arif, ERTÜRK, Ahmet, ÖZTORUN, Can İhsan, DEMİR, Sabri, AZILI, Müjdem Nur, and ŞENEL, Emrah
- Subjects
- *
OROPHARYNGEAL cancer , *NEWBORN infants - Abstract
Epignathus also known as oropharyngeal teratoma is a very rare tumor in newborns, which has a female predominance. The treatment is simple excision of the mass surgically which should not be delayed. We operated a male newborn due to intraoral mass causing episodic deglution and respiration problems. The histopathology was reported as epignathus and this case is discussed based on the current literature because of its rarity. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
30. Giant Epignathus (Teratoma of Palatine Tonsil): A Case Report
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Mehmet Akif Eryilmaz, Mert Mutaf, and Fuat Aydemir
- Subjects
Epignathus ,medicine.medical_specialty ,Fetus ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Airway obstruction ,medicine.disease ,Complete resection ,Palatine tonsil ,medicine.anatomical_structure ,pediatric otorhinolaryngology ,medicine ,case report ,fetal anomaly ,Radiology ,Teratoma ,teratoma ,Airway ,business ,palatine tonsil - Abstract
Teratomas are benign tumours containing tissues derived from ectoderm, endoderm and mesoderm Epignathus is a rare congenital teratoma and originates from oropharyngeal region. We present a case of giant epignathus arising from tonsillar region in a neonate. A male neonate that was born with a 38-week cesarean section presented with a pedunculated mass from left tonsilla palatina and protruding outside the mouth. The patient did not have any airway problem. Magnetic resonance imaging and computed tomography scan showed no intracranial extension. The patient was operated on the postpartum 3rd day and the mass was excised successfully. After histopathological examination, mature teratoma was diagnosed. During post-operative 6 months control visit, there was no recurrence. Epignathus is a rare congenital oropharyngeal teratoma, it should be diagnosed in the fetus as early as possible. Teratomas of the tonsilla palatina are extremely rare. In such cases, the mass may cause airway obstruction and feeding difficulties so complete resection is curative in most cases during the early neonatal period.
- Published
- 2021
31. Prenatal Diagnosis of a Giant Epignathus in the Second Trimester and Immediate Successful Management at Birth: A Case Report
- Author
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Xiaoyu Hu, Lin Xu, Yunqing Chen, Xiaofei Wang, Min Zhao, and Yijing Chu
- Subjects
medicine.medical_specialty ,Obstetrics ,Second trimester ,business.industry ,Pediatrics, Perinatology and Child Health ,medicine ,Obstetrics and Gynecology ,Prenatal diagnosis ,Epignathus ,business - Published
- 2021
32. Prenatal Diagnosis of Fetal Immature Oropharyngeal Teratoma in the First Trimester: A Case Report
- Author
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Shaheen Banu, Seneesh Kumar Vikraman, Aditi Dubey, Nithya Elango, and Hafiz Mohamad
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,030219 obstetrics & reproductive medicine ,Soft palate ,business.industry ,Prenatal diagnosis ,030105 genetics & heredity ,medicine.disease ,Epignathus ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Tongue ,Modeling and Simulation ,Tonsil ,medicine ,Teratoma ,Hard palate ,business ,Nose - Abstract
Epignathus or oro-pharyngeal teratoma is an extremely rare, benign congenital tumor, occurring in 1 in 35,000–200,000 live births. They usually arise from the sphenoid region of the hard palate, posterior nasopharynx, upper lip and nose, soft palate, tonsil or tongue. The typical appearance is that of a solid irregular mass containing both cystic and solid elements, protruding from the oral cavity. Their occurrence in the first trimester is extremely rare. We report a case of fetal immature orofacial teratoma detected in the first trimester and confirmed with histopathological diagnosis. The index pregnancy presented at 13 1/7 weeks of gestation. Ultrasound examination demonstrated an irregular, mixed echogenic mass with solid and cystic components protruding from the fetal mouth, between the tongue and the palate. Following extensive counselling, the couple opted for termination of the pregnancy. Histopathological examination confirmed the tumor to be an immature oral teratoma.
- Published
- 2021
33. Case report and review of the literature: rare fetus-in-fetu presenting as oropharyngeal epignathus.
- Author
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Runggaldier D, Reinehr M, Friedrich H, Henze G, Good D, and Gysin C
- Abstract
An epignathus is caused by a continuous spectrum of masses of the oral cavity or oropharynx ranging in its entity from mature teratoma to the exceedingly rare fetus-in-fetu. Due to its location, regardless of the entity, the occurrence of an epignathus is frequently associated with life threatening airway obstruction. Here we demonstrate a case of a fetus-in-fetu presenting as an epignatus. We describe its successful management and review the available literature. Early diagnosis and knowledge of the preoperative workup are essential to enable a multidisciplinary management. Once the airway is secured, surgical excision is the treatment of choice often resulting in a good clinical outcome and prognosis., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2023 Runggaldier, Reinehr, Friedrich, Henze, and Gysin.)
- Published
- 2023
- Full Text
- View/download PDF
34. A Case Report of a Massive Epignathus
- Author
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Farhad Naleini, Mahmood Mehrbakhsh, Parisa Bahrami Kamangar, and Nazanin Farshchian
- Subjects
Pregnancy ,Fetus ,medicine.medical_specialty ,Tumor size ,business.industry ,Obstetrics ,medicine.medical_treatment ,Prenatal diagnosis ,Case Report ,General Medicine ,medicine.disease ,Epignathus ,Curettage ,epignathus ,medicine ,Gestation ,Teratoma ,teratoma ,business - Abstract
Epignathus is a rare congenital orofacial teratoma. Teratomas are tumors that originate from all three germs cell layers. Tumor size is an important prognostic factor, and we describe the case of massive epignathus identified by sonography at 25 weeks. Our case was a 35-year-old pregnant woman that was subjected to a routine ultrasound at 25 weeks of gestation, and epignathus was diagnosed. Labor pain started in the 28th week of the pregnancy, so the dead fetus was aborted, and curettage was conducted. A pathologic sample was sent to the laboratory, and benign teratoma was diagnosed. Because fetal epignathus has a wide range of outcomes, early prenatal diagnosis is essential for optimal management.
- Published
- 2020
35. CONGENITAL DENTOFACIAL ANOMALY. A HISTORY CASE OF SURGICAL TREATMENT OF TERATOID TUMOR ASSOCIATED WITH CONGENITAL CLEFT LIP AND PALATE IN A CHILD
- Author
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O. V. Nelyubina, A. A. Mamedov, and I. V. Kirgizov
- Subjects
epignathus ,congeninal dentofacial anomaly ,teratoid tumor ,congenital cleft lip and palate ,children ,Pediatrics ,RJ1-570 - Abstract
The authors describe a history case of severe congenital dentofacial anomaly with congenital cleft lip, palate and alveolar ridge, associated with somatic disease. The diagnosis was confirmed histologically. The surgical treatment was performed after the careful presurgical preparation due to severe general condition of the child. The indication to the surgical treatment was a significant enlargement of the tumor mass since the child’s birth. The tumor filled the oral cavity and blocked oropharynx almost completely.
- Published
- 2012
- Full Text
- View/download PDF
36. Congenital Giant Epignathus with Intracranial Extension in a Fetal
- Author
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Ai-Chun Wang, Yi-Qun Gu, and Xiu-Yun Zhou
- Subjects
Congenital ,Epignathus ,Fetal ,Medicine - Published
- 2017
- Full Text
- View/download PDF
37. The EXIT (Ex Utero Intrapartum Treatment) Procedure
- Author
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Hsin-Hui Chiu, Wei-Chung Hsu, Jin-Chung Shih, Po-Nien Tsao, Wu-Shiun Hsieh, and Hung-Chieh Chou
- Subjects
epignathus ,EXIT procedure ,lymphangioma ,Medicine (General) ,R5-920 - Abstract
Fetuses with upper airway obstruction have a high mortality rate if proper airway management is not immediately administered after delivery. The EXIT (ex utero intrapartum treatment) procedure is a new technique that establishes the fetal airway while uteroplacental circulation is still maintained. The prognosis of such neonates has much improved after the introduction of this procedure. We report two neonates with prenatal diagnosis of upper airway obstruction; they were born smoothly via the EXIT procedure. The first was a case of epignathus, a rare type of nasopharyngeal or oropharyngeal teratoma derived from all three germ cell layers with variable maturity. The second was a case of giant lymphangioma that resulted from localized malformations in the development of the lymphatic system. Furthermore, compared with routine cesarean section, the short-term maternal outcomes were not different with regard to infection rate, estimated blood loss, wound complication, and postpartum hospital stay.
- Published
- 2008
- Full Text
- View/download PDF
38. Teratoma oral: la importancia del diagnóstico prenatal y el trabajo interdisciplinario: un caso clínico
- Author
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Santiago Vidaurreta, Yamile Rubies, Mónica N Pose, Camila Parellada, Daniel Saint Genez, Mariana Vázquez Durand, and Delcys Albas Maubett
- Subjects
medicine.medical_specialty ,business.industry ,Obstetrics ,Prenatal diagnosis ,Congenital malformations ,medicine.disease ,Epignathus ,Fetal circulation ,Pediatrics, Perinatology and Child Health ,Female patient ,Medicine ,Teratoma ,business ,Airway ,Head and neck - Abstract
Thanks to technological advances, it has been possible to carry out the prenatal diagnosis of different life-threatening congenital malformations. Among these, oral teratoma, or epignathus, is a rare form of congenital teratoma within those located in the head and neck. They are generally benign and comprise 4 % of neonatal teratomas. From the development of the EXIT technique (ex utero intrapartum treatment), which has been implemented since the 90's to support fetal circulation until the newborn's airway is secured, it is possible to plan a multidisciplinary management strategy that enables the correct approach of these pathologies. We present a case of giant epignathus in a 35-week gestation female patient, whose airway was secured using the EXIT technique, and follow up.
- Published
- 2021
39. Teratoma congênito de orofaringe: relato de caso Oropharyngeal congenital teratoma: a case report
- Author
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Yuri Seguchi Chaves, Jânio Serafim de Sousa, Paulo Cezar Feldner Jr, Reisson Serafim Cruz, Marair G. F. Sartori, Manuel J.B.C. Girão, and Hiromi Seguchi Chaves
- Subjects
Epignathus ,Teratoma congênito ,Tumores fetais ,Malformações-fetais ,Óbito fetal ,Prematuridade ,Congenital teratoma ,Fetal tumor ,Fetal malformations ,Fetal death ,Prematurity ,Gynecology and obstetrics ,RG1-991 - Abstract
O teratoma congênito de orofaringe é o tipo mais raro de teratoma, compreendendo apenas 2% desses tumores fetais. O diagnóstico deve ser realizado o mais precocemente possível, preferencialmente durante o pré-natal. O prognóstico irá depender do tamanho e localização da lesão, da velocidade de crescimento desta, do envolvimento de estruturas intracranianas e da ressecção adequada do tumor com equipe multidisciplinar. Relatamos o caso de uma paciente que teve diagnosticado durante a gestação feto com teratoma congênito de orofaringe (epignathus) por meio de ultra-sonografia. O feto evoluiu para óbito intra-uterino na 29ª semana de gestação, sendo então induzido o parto por via vaginal. O exame anatomopatológico revelou feto do sexo feminino, compatível com 27-28 semanas, teratoma orofaríngeo e outras malformações congênitas.Oropharyngeal teratoma is the most rare type of teratoma, with only 2% of fetal teratomas. The diagnosis must be established as early as possible, preferably during the prenatal period. The prognosis will depend on the size and location of the lesion, growth rate of the lesion, degree of intracranial spread, its resectability, and immediate care at birth by a multisciplinary team. We report aparticular case of congenital oropharyngeal teratoma (epignathus). The diagnosis was made during the prenatal period by ultrasound, and the fetus evolved to intrauterine death at the 29th week. The anatomopathological examination revealed a female fetus, compatible with 27-28 weeks, oropharyngeal teratoma and congenital malformations.
- Published
- 2005
- Full Text
- View/download PDF
40. EPIGNATHUS: REPORTE DE UN CASO Y REVISIÓN DE LA LITERATURA
- Author
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Ivonne Escobar G., Andrés Poblete L., Jorge Becker V., Alejandro Zavala B., Javier Kattan S., Soledad Urzúa B., and Jorge Carvajal C.
- Subjects
Epignathus ,tumor fetal ,procedimiento EXIT ,fetal tumor ,EXIT procedure ,Gynecology and obstetrics ,RG1-991 - Abstract
Epignathus es una forma infrecuente de teratoma de localización orofaríngea que protruye por la boca y se asocia a una alta tasa de mortalidad causada por obstrucción severa de la vía aérea en el período neonatal. La clave del éxito del manejo de la obstrucción es a través del diagnóstico prenatal precoz y la ejecución controlada del EXIT (ex-utero intrapartum treatment), procedimiento utilizado para asegurar la vía aérea fetal. Describimos un caso de epignathus gigante y la aplicación del EXIT para el manejo de la vía aérea a través de la preservación del intercambio gaseoso uteroplacentarioEpignahtus is an uncommon form of teratoma, located in the oropharynge, which protrudes through the mouth and that is associated with a high mortality during the neonatal period. The key to a successful outcome in managing of the airway obstruction is early prenatal diagnosis and the controlled execution of the EXIT (ex-utero intrapartum treatment) to secure the fetal airway. We report a case of a giant epignathus and the application of EXIT procedure, in which time to secure an airway is provided while preserving uteroplacental gas exchange
- Published
- 2005
41. Epignathus with oropharynx destruction
- Author
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Francesco Colasurdo, Massimiliano Guerriero, and Valerio Pellegrini
- Subjects
Pathology ,medicine.medical_specialty ,endocrine system ,endocrine system diseases ,Epignathus ,Oral cavity ,urologic and male genital diseases ,Pathology and Forensic Medicine ,Oral Teratoma ,Fetus ,Internal Medicine ,medicine ,Autopsy Case Report and Review ,Head and neck ,Pharyngeal mass ,neoplasms ,Histological examination ,business.industry ,medicine.disease ,RC31-1245 ,female genital diseases and pregnancy complications ,Medicine ,Immature teratoma ,Teratoma ,business - Abstract
Epignathus, is a rare oropharyngeal teratoma arising from the head and neck region. Sporadic cases have been described with associated intracerebral teratoma. Even more infrequent and extraordinary is the circumstance of a teratoma with oropharynx destruction. We describe the case of a fetus with pharyngeal mass that completely destroyed the oral cavity. The histological examination revealed an immature teratoma (G3); only one other G3 case has been described.
- Published
- 2021
42. Oropharyngeal epignathus with partial facial duplication: report of a rare case.
- Author
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Herath, M., Siriwardena, B.S.M.S., Jayasinghe, R.D., and Dias, D.K.
- Subjects
TERATOMA ,CONJOINED twins - Abstract
Foetal oral teratoma or epignathus is a rare benign condition that originates in the oropharyngeal region. The term ‘teratoma’ refers to a mass composed of poorly organized tissues derived from each of the three germ layers. Epignathus may occur when one twin ceases development during gestation and becomes vestigial to the fully formed dominant twin. The reported incidence of epignathus is approximately 1:35,000 to 1:200,000 live births. A unique case of partial facial duplication with gross histological and radiological evidence of partial duplication of the facial elements and organs is presented herein. The affected newborn baby underwent urgent surgery due to breathing difficulties. The mass was excised successfully and the infant made an uneventful recovery. The resected specimen included two developing faces, each composed of a developing mandible and maxilla with developing tooth buds. Tissues from all three germ layers were present. In such cases, the treatment option is exclusively surgical, and complete resection is curative in most cases during the early neonatal period. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
43. Airway management with Airtraq in a neonate with Epignathus. A case report
- Author
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Atif Khalid, Danish Hushain, Mohit Prakash, and Farah Nasreen
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Case Report ,Airtraq ,Epignathus ,Feeding difficulty ,lcsh:RD78.3-87.3 ,03 medical and health sciences ,0302 clinical medicine ,030202 anesthesiology ,medicine ,Difficult airway ,airway management ,business.industry ,030208 emergency & critical care medicine ,Surgery ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,epignathus ,lcsh:Anesthesiology ,Breathing ,Surgical excision ,Airway management ,Hard palate ,neonate ,business - Abstract
Presence of intraoral pathology especially in neonates poses a great challenge during airway management. Epignathus is a rare form of teratoid tumour that arises from the oropharyngeal region. We hereby report a case of a 7-day-old neonate who presented with feeding difficulty secondary to swelling arising from the hard palate. Surgical excision was decided to overcome feeding difficulty and to enable the child to thrive better. In view of anticipated difficult airway, the child was induced with sevoflurane, maintaining spontaneous breathing and intubated with Airtraq optical laryngoscope size 0. The further intraoperative and postoperative period was uneventful.
- Published
- 2020
44. Neonatal epignathus in the oral and pharyngeal regions: A case report
- Author
-
Tsuyoshi Isojima, Jun Fujishiro, Kosuke Kanke, Hideyuki Suenaga, Kazuto Hoshi, and Madoka Sugiyama
- Subjects
Otorhinolaryngology ,business.industry ,Medicine ,Anatomy ,business ,Epignathus - Published
- 2019
45. Oral Epignathus with Maxilla Duplication: Report of a Rare Case
- Author
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Roberto S. Tunes, Gabriel Z. Cavalcanti, Lucas Gomes Patrocinio, and José Mauro O. Squarisi
- Subjects
medicine.medical_specialty ,business.industry ,Airway obstruction ,medicine.disease ,Epignathus ,medicine.anatomical_structure ,Otorhinolaryngology ,Maxilla ,Rare case ,Gene duplication ,medicine ,Surgery ,Teratoma ,Hard palate ,Radiology ,Oral Surgery ,business ,Calcification - Abstract
Epignathus is a rare congenital oropharyngeal teratoma that arises from the oropharynx, especially the sphenoid, palatine, and ethmoid bones. Teratomas are benign tumors containing cells from ectodermal, mesodermal, and endodermal layers. The incidence of epignathus is between 1:35,000 and 1:200,000 live births with a female predominance. We reported an uncommon case of epignathus in a female newborn baby with an ill-defined oral mass protruding through a cleft in the hard palate. Computed tomography scan showed a contrast-enhanced solid mass with areas of calcification simulating a unique case of maxilla duplication. Surgery was performed, the mass was excised successfully, and microscopic analysis confirmed the diagnosis of mature teratoma. The patient evolved with good general health and showed no clinical signs of recurrence. Although epignathus is a rare condition, it should be diagnosed in the fetus as early as possible, especially to avoid fatal airway obstruction. In such cases, the treatment option is exclusively surgical, and complete resection is curative in most cases during the early neonatal period.
- Published
- 2019
46. Epignathus with Fetiform Features
- Author
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Kumar Sunil Y., Shrikrishna U., Jayaprakash Shetty, and Aishwarya Sitaram
- Subjects
epignathus ,fetiform ,immature teratoma ,resection ,Medicine - Abstract
Epignathus is an extremely rare oropharyngeal teratoma that commonly arises from the palate, leading to a high mortality (80-100%) due to airway obstruction in the neonatal period. We present a case of epignathus immature teratoma with fetiform features, originating from basisphenoid in a 28-week preterm male baby, who succumbed to death immediately after birth. Since epignathus is a life-threatening condition at the time of delivery, a prenatal diagnosis is essential to coordinate the treatment and appropriate management by securing the airway, either by endotracheal intubation or tracheostomy followed by complete resection of the tumor.
- Published
- 2011
- Full Text
- View/download PDF
47. Fetal epignathus: texture analysis beyond surface of tissue using three-dimensional reconstruction models from ultrasound and magnetic resonance imaging data
- Author
-
Pedro Teixeira Castro, Gerson Ribeiro, E. Araujo Junior, J. L. dos Santos, Heron Werner, and F. M. Peixoto-Filho
- Subjects
Surface (mathematics) ,Magnetic Resonance Imaging Scan ,Radiological and Ultrasound Technology ,business.industry ,Ultrasound ,Teratoma ,Obstetrics and Gynecology ,General Medicine ,Epignathus ,Magnetic Resonance Imaging ,Ultrasonography, Prenatal ,Craniopharyngioma ,Imaging, Three-Dimensional ,Reproductive Medicine ,Pregnancy ,Nasopharynx ,Medical Illustration ,Image Processing, Computer-Assisted ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Female ,Texture (crystalline) ,business ,Biomedical engineering - Published
- 2021
48. Management of oropharyngeal teratoma: Two case reports and a literature review
- Author
-
Xiaoyan Li and Peng Zhu
- Subjects
medicine.medical_specialty ,Polyhydramnios ,Medicine (General) ,Case Report ,Prenatal diagnosis ,Epignathus ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,R5-920 ,Pregnancy ,Prenatal Diagnosis ,medicine ,Humans ,Oropharyngeal teratoma ,Histological examination ,cleft palate ,030219 obstetrics & reproductive medicine ,Cleft tongue ,business.industry ,Biochemistry (medical) ,Infant, Newborn ,Teratoma ,Infant ,Cell Biology ,General Medicine ,Airway obstruction ,medicine.disease ,Surgery ,030220 oncology & carcinogenesis ,Female ,Mouth Neoplasms ,Neoplasm Recurrence, Local ,tongue cracking ,Ultrasonography ,business - Abstract
Pharyngeal teratomas are very rare congenital tumours derived from pluripotent stem cells. Surgical resection is the main treatment to avoid breathing and feeding difficulties. This current case report describes two newborn infants with congenital oropharyngeal teratomas. In one of the infants, the tumour presented along with a cleft tongue and cleft palate. Prenatal diagnosis by ultrasonography did not identify the tumours because the masses were small and there was no polyhydramnios. Both cases were treated surgically and histological examination of the masses in both cases confirmed the diagnosis of a congenital epignathus. There were no complications such as infection, bleeding or residual recurrence following surgery. After 1-year follow-up, there was no recurrence of the epignathus in either case. Oropharyngeal teratoma is a very rare congenital tumour that may cause upper airway obstruction and feeding difficulties in the newborn, so it should be treated surgically in a timely manner.
- Published
- 2021
49. Oropharyngeal teratoma, oral duplication, cervical diplomyelia and anencephaly in a 22-week fetus: A review of the craniofacial teratoma syndrome.
- Author
-
Morlino, Silvia, Castori, Marco, Servadei, Francesca, Laino, Luigi, Silvestri, Evelina, and Grammatico, Paola
- Abstract
Background Oropharyngeal teratoma may occur by itself or together with other craniofacial malformations, most commonly cleft palate. Oropharyngeal teratoma may be also seen in association with frontonasal dysplasia and/or various degrees of craniofacial duplication. The nosology of these sporadic disorders is poorly defined. Case and Review We report on a 22-week fetus with a protruding nasopharyngeal teratoma, partial oral duplication, anencephaly, multiple costo-vertebral segmentation defects, and cervical diplomyelia. A review of the literature identified 48 patients published from 1931 to 2013 with co-existing clefting and duplication anomalies of the cephalic pole. Thoracic and abdominal midline anomalies were reported 13 times. Conclusion The term 'craniofacial teratoma syndrome' is introduced to define this phenotype as a recognizable developmental field defect of the cephalic pole. Developmental pathogenesis is discussed with a focus on pleiotropy and stereotaxis. The observation of midline findings suggestive of holoprosencephaly in a few previously reported cases suggests a role for the sonic hedgehog signaling pathway in this malformation pattern. Birth Defects Research (Part A) 103:554-566, 2015. © 2014 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
50. Giant Epignathus Tumor Associated with Disseminated Intravascular Coagulation: A Case Report and Literature Review.
- Author
-
Samraj, Ravi Shankar and Almond, Stephen
- Subjects
- *
HEAD & neck cancer , *DISSEMINATED intravascular coagulation , *CONGENITAL disorders , *CANCER complications , *DISEASE management , *RESPIRATORY obstructions - Abstract
Epignathus is a rare congenital head and neck tumor (1 in 35,000-200,000 live births) with many associated complications. We report a rare association of giant epignathus associated with disseminated intravascular coagulation. To our knowledge, only one case of this association has been reported so far. A review of different clinical presentations of epignathus, classification, its reported associations and available management strategies is included. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
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