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This textbook provides the basic concepts of epidemiology while preparing readers with the skills of applying statistical tools in real-life situations. Students, in general, struggle with statistical theories and their practical applications. This book makes statistical concepts easy to understand by focusing on real-life examples, case studies, and exercises. It also provides step-by-step guides for data analysis and interpretation using standard statistical software such as SPSS, SAS, R, Python, and GIS as appropriate, illustrating the concepts.Through the book's 23 chapters, readers primarily learn how to apply statistical methods in epidemiological studies and problem-solving. Among the topics covered:Clinical TrialsEpidemic Investigation and ControlGeospatial Applications in EpidemiologySurvival Analysis and Applications Using SAS and SPSSSystematic Review and Meta-Analysis: Evidence-based Decision-Making in Public HealthMissing Data Imputation: A Practical Guide Artificial Intelligence and Machine LearningMultivariate Linear Regression and Logistics Regression Analysis Using SASEach chapter is written by eminent scientists and experts worldwide, including contributors from institutions in the United States, Canada, Bangladesh, India, Hong Kong, Malaysia, and the Middle East. Statistical Approaches for Epidemiology: From Concept to Application is an all-in-one book that serves as an essential text for graduate students, faculty, instructors, and researchers in public health and other branches of health sciences, as well as a useful resource for health researchers in industry, public health and health department professionals, health practitioners, and health research organizations and non-governmental organizations. The book also will be helpful for graduate students and faculty in related disciplines such as data science, nursing, social work, environmental health, occupational health, computer science, statistics, and biology.

This book addresses the description and analysis of occurrence data frequently encountered in epidemiological studies. With the occurrence of Covid-19, people have been exposed to the analysis and interpretation of epidemiological data. To be informed consumers of this information, people need to understand the nature and analysis of these data. Effort is made to emphasize concepts rather than mathematics. Subjects range from description of the frequencies of disease to the analysis of associations between the occurrence of disease and exposure. Those analyses begin with simple associations and work up to complex relationships that involve the control of extraneous characteristics. Analyses rely on the statistical software R, which is freeware in wide use by professional epidemiologists and other scientists.

This book covers classic epidemiological designs that use a reference/control group, including case-control, case-cohort, nested case-control and variations of these designs, such as stratified and two-stage designs. It presents a unified view of these sampling designs as representations of an underlying cohort or target population of interest. This enables various extended designs to be introduced and analysed with a similar approach: extreme sampling on the outcome (extreme case-control design) or on the exposure (exposure-enriched, exposure-density, countermatched), designs that re-use prior controls and augmentation sampling designs. Further extensions exploit aggregate data for efficient cluster sampling, accommodate time-varying exposures and combine matched and unmatched controls. Self-controlled designs, including case-crossover, self-controlled case series and exposure-crossover, are also presented. The test-negative design for vaccine studies and the use of negative controls for bias assessment are introduced and discussed.This book is intended for graduate students in biostatistics, epidemiology and related disciplines, or for health researchers and data analysts interested in extending their knowledge of study design and data analysis skills.This book Bridges the gap between epidemiology and the more mathematically oriented biostatistics books. Assembles the wealth of epidemiological knowledge about observational study designs that is scattered over several decades of scientific publications. Illustrates the performance of methods in real research applications. Provides guidelines for implementation in standard software packages (Stata, R). Includes numerous exercises, covering simple mathematical proofs, consideration of proposed or published designs, and practical data analysis.

Data Science for Infectious Disease Data Analytics: An Introduction with R provides an overview of modern data science tools and methods that have been developed specifically to analyze infectious disease data. With a quick start guide to epidemiological data visualization and analysis in R, this book spans the gulf between academia and practices providing many lively, instructive data analysis examples using the most up-to-date data, such as the newly discovered coronavirus disease (COVID-19).The primary emphasis of this book is the data science procedures in epidemiological studies, including data wrangling, visualization, interpretation, predictive modeling, and inference, which is of immense importance due to increasingly diverse and nonexperimental data across a wide range of fields. The knowledge and skills readers gain from this book are also transferable to other areas, such as public health, business analytics, environmental studies, or spatio-temporal data visualization and analysis in general.Aimed at readers with an undergraduate knowledge of mathematics and statistics, this book is an ideal introduction to the development and implementation of data science in epidemiology.Features Describes the entire data science procedure of how the infectious disease data are collected, curated, visualized, and fed to predictive models, which facilitates effective communication between data sources, scientists, and decision-makers. Explains practical concepts of infectious disease data and provides particular data science perspectives. Overview of the unique features and issues of infectious disease data and how they impact epidemic modeling and projection. Introduces various classes of models and state-of-the-art learning methods to analyze infectious diseases data with valuable insights on how different models and methods could be connected.

'This book bridges the fields of health care and data to clarify how to use data to manage pandemics. Written while COVID-19 was raging, it identifies both effective practices and misfires, and is grounded in clear, research-based explanations of pandemics and data strategy….The author has written an essential book for students and professionals in both health care and data. While serving the needs of academics and experts, the book is accessible for the general reader.'– Eileen Forrester, CEO of Forrester Leadership Group, Author of CMMI for Services, Guidelines for Superior Service'…Rupa Mahanti explores the connections between data and the human response to the spread of disease in her new book,... She recognizes the value of data and the kind of insight it can bring, while at the same time recognizing that using data to solve problems requires not just technology, but also leadership and courage. This is a book for people who want to better understand the role of data and people in solving human problems.'-- Laura Sebastian-Coleman, Author of Meeting the Challenges of Data Quality ManagementIn contrast to the 1918 Spanish flu pandemic which occurred in a non-digital age, the timing of the COVID-19 pandemic intersects with the digital age, characterized by the collection of large amounts of data and sophisticated technologies. Data and technology are being used to combat this digital age pandemic in ways that were not possible in the pre-digital age.Given the adverse impacts of pandemics in general and the COVID-19 pandemic in particular, it is imperative that people understand the meaning, origin of pandemics, related terms, trajectory of a new disease, butterfly effect of contagious diseases, factors governing the pandemic potential of a disease, strategies to combat a pandemic, role of data, data sharing, data strategy, data governance, analytics, and data visualization in managing pandemics, pandemic myths, critical success factors in managing pandemics, and lessons learned. How Data Can Manage Global Health Pandemics: Analyzing and Understanding COVID-19 discusses these elements with special reference to COVID-19.Dr. Rupa Mahanti is a business and data consultant and has expertise in different data management disciplines, business process improvement, regulatory reporting, quality management, and more. She is the author of Data Quality (ASQ Quality Press) and the series Data Governance: The Way Forward (Springer).

Now in a fully revised Fourth Edition, Modern Epidemiology remains the gold standard text in this complex and evolving field. This edition continues to provide comprehensive coverage of the principles and methods for the design, analysis, and interpretation of epidemiologic research. Featuring a new format allowing space for margin notes, this edition • Reflects both the conceptual development of this evolving science and the increasing role that epidemiology plays in improving public health and medicine. • Features new coverage of methods such as agent-based modeling, quasi-experimental designs, mediation analysis, and causal modeling. • Updates coverage of methods such as concepts of interaction, bias analysis, and time-varying designs and analysis. • Continues to cover the full breadth of epidemiologic methods and concepts, including epidemiologic measures of occurrence and effect, study designs, validity, precision, statistical interference, field methods, surveillance, ecologic designs, and use of secondary data sources. • Includes data analysis topics such as Bayesian analysis, probabilistic bias analysis, time-to-event analysis, and an extensive overview of modern regression methods including logistic and survival regression, splines, longitudinal and cluster-correlated/hierarchical data analysis, propensity scores and other scoring methods, and marginal structural models. • Summarizes the history, specialized aspects, and future directions of topical areas, including among others social epidemiology, infectious disease epidemiology, genetic and molecular epidemiology, psychiatric epidemiology, injury and violence epidemiology, and pharmacoepidemiology.

This book is designed to train graduate students across disciplines within the fields of public health and medicine, with the goal of guiding them in the transition to independent researchers. It focuses on theories, principles, techniques, and methods essential for data processing and quantitative analysis to address medical, health, and behavioral challenges. Students will learn to access to existing data and process their own data, quantify the distribution of a medical or health problem to inform decision making; to identify influential factors of a disease/behavioral problem; and to support health promotion and disease prevention. Concepts, principles, methods and skills are demonstrated with SAS programs, figures and tables generated from real, publicly available data. In addition to various methods for introductory analysis, the following are featured, including 4-dimensional measurement of distribution and geographic mapping, multiple linear and logistic regression, Poissonregression, Cox regression, missing data imputing, and statistical power analysis.

Researches and Applications of Artificial Intelligence to Mitigate Pandemics: History, Diagnostic Tools, Epidemiology, Healthcare, and Technology offers readers an interdisciplinary view of state-of-art research related to the COVID-19 outbreak, with a focus on tactics employed to model the number of cases of COVID-19 (time series modeling), models employed to diagnostics COVID-19 based on images, and the panoramic of COVID-19 since its discovery and up to this book's publication. This book showcases the algorithms and models available to manage pandemic data, the role of AI, IoT and Mathematical Modeling, how to prevent and fight COVID-19, and the existing medical, social and pharmaceutical support. Chapters cover methods and protocols, the basics and history of diseases, the fast diagnosis of disease with different automated algorithms and artificial intelligence tools and techniques, the methods of handling epidemiology for mitigating the spread of disease, artificial intelligence and mathematical modeling techniques, and how mental and physical health is affected with social media usage. - Explains novel and hybrid high quality artificial intelligence methodologies, techniques, algorithms, architectures, tools and methods to cope with pandemics - Covers rapid point-of-care diagnostics, presents details on varied mathematical models developed to control epidemiology, and lists existing measures to disseminate the spread of infection using computational methods - Highlights the negative effect of social media and other sources by applying preventive measures to combat depression and anxiety

This textbook and guide focuses on methodologies for bias analysis in epidemiology and public health, not only providing updates to the first edition but also further developing methods and adding new advanced methods. As computational power available to analysts has improved and epidemiologic problems have become more advanced, missing data, Bayes, and empirical methods have become more commonly used. This new edition features updated examples throughout and adds coverage addressing: Measurement error pertaining to continuous and polytomous variables Methods surrounding person-time (rate) data Bias analysis using missing data, empirical (likelihood), and Bayes methods A unique feature of this revision is its section on best practices for implementing, presenting, and interpreting bias analyses. Pedagogically, the text guides students and professionals through the planning stages of bias analysis, including the design of validation studies and the collection of validity data from other sources. Three chapters present methods for corrections to address selection bias, uncontrolled confounding, and measurement errors, and subsequent sections extend these methods to probabilistic bias analysis, missing data methods, likelihood-based approaches, Bayesian methods, and best practices.

This practical guide is designed for students and researchers with an existing knowledge of R who wish to learn how to apply it in an epidemiological context and exploit its versatility. It also serves as a broader introduction to the quantitative aspects of modern practical epidemiology. The standard tools used in epidemiology are described and the practical use of R for these is clearly explained and laid out. R code examples, many with output, are embedded throughout the text. The entire code is also available on the companion website so that readers can reproduce all the results and graphs featured in the book. Epidemiology with R is an advanced textbook suitable for senior undergraduate and graduate students, professional researchers, and practitioners in the fields of human and non-human epidemiology, public health, veterinary science, and biostatistics.

COVID-19 has hit the world unprepared, as the deadliest pandemic of the century. Governments and authorities, as leaders and decision makers fighting the virus, enormously tap into the power of artificial intelligence and its predictive models for urgent decision support. This book showcases a collection of important predictive models that used during the pandemic, and discusses and compares their efficacy and limitations. Readers from both healthcare industries and academia can gain unique insights on how predictive models were designed and applied on epidemic data. Taking COVID19 as a case study and showcasing the lessons learnt, this book will enable readers to be better prepared in the event of virus epidemics or pandemics in the future.

With COVID-19 sweeping across the globe with near impunity, it is thwarting governments and health organizations efforts to contain it. Not since the 1918 Spanish Flu have citizens of developed countries experienced such a large-scale disease outbreak that is having devastating health and economic impacts. One reason such outbreaks are not more common has been the success of the public health community, including epidemiologists and biostatisticians, in identifying and then mitigating or eliminating the outbreaks. Monitoring the Health of Populations by Tracking Disease Outbreaks: Saving Humanity from the Next Plague is the story of the application of statistics for disease detection and tracking. The work of public health officials often crucially depends on statistical methods to help discern whether an outbreak may be occurring and, if there is sufficient evidence of an outbreak, then to locate and track it. Statisticians also help collect critical information, and they analyze the resulting data to help investigators zero in on a cause for a disease. With the recent outbreaks of diseases such as swine and bird flu, Ebola, and now COVID-19, the role that epidemiologists and biostatisticians play is more important than ever.Features:· Discusses the crucial roles of statistics in early disease detection.· Outlines the concepts and methods of disease surveillance.· Covers surveillance techniques for communicable diseases like Zika and chronic diseases such as cancer.· Gives real world examples of disease investigations including smallpox, syphilis, anthrax, yellow fever, and microcephaly (and its relationship to the Zika virus).Via the process of identifying an outbreak, finding its cause, and developing a plan to prevent its reoccurrence, this book tells the story of how medical and public health professionals use statistics to help mitigate the effects of disease. This book will help readers understand how statisticians and epidemiologists help combat the spread of such diseases in order to improve public health across the world.

This book examines statistical methods and models used in the fields of global health and epidemiology. It includes methods such as innovative probability sampling, data harmonization and encryption, and advanced descriptive, analytical and monitory methods. Program codes using R are included as well as real data examples. Contemporary global health and epidemiology involves a myriad of medical and health challenges, including inequality of treatment, the HIV/AIDS epidemic and its subsequent control, the flu, cancer, tobacco control, drug use, and environmental pollution. In addition to its vast scales and telescopic perspective; addressing global health concerns often involves examining resource-limited populations with large geographic, socioeconomic diversities. Therefore, advancing global health requires new epidemiological design, new data, and new methods for sampling, data processing, and statistical analysis. This book provides global health researchers with methods that will enable access to and utilization of existing data. Featuring contributions from both epidemiological and biostatistical scholars, this book is a practical resource for researchers, practitioners, and students in solving global health problems in research, education, training, and consultation.

Disease Mapping: From Foundations to Multidimensional Modeling guides the reader from the basics of disease mapping to the most advanced topics in this field. A multidimensional framework is offered that makes possible the joint modeling of several risks patterns corresponding to combinations of several factors, including age group, time period, disease, etc. Although theory will be covered, the applied component will be equally as important with lots of practical examples offered. Features: Discusses the very latest developments on multivariate and multidimensional mapping. Gives a single state-of-the-art framework that unifies most of the previously proposed disease mapping approaches. Balances epidemiological and statistical points-of-view. Requires no previous knowledge of disease mapping. Includes practical sessions at the end of each chapter with WinBUGs/INLA and real world datasets. Supplies R code for the examples in the book so that they can be reproduced by the reader. About the Authors:Miguel A. Martinez Beneito has spent his whole career working as a statistician for public health services, first at the epidemiology unit of the Valencia (Spain) regional health administration and later as a researcher at the public health division of FISABIO, a regional bio-sanitary research center. He has been also the Bayesian Hierarchical Models professor for several seasons at the University of Valencia Biostatics Master. Paloma Botella Rocamora has spent most of her professional career in academia although she now works as a statistician for the epidemiology unit of the Valencia regional health administration. Most of her research has been devoted to developing and applying disease mapping models to real data, although her work as a statistician in an epidemiology unit makes her develop and apply statistical methods to health data, in general.

This book provides a systematic treatment of the mathematical underpinnings of work in the theory of outbreak dynamics and their control, covering balanced perspectives between theory and practice including new material on contemporary topics in the field of infectious disease modelling. Specifically, it presents a unified mathematical framework linked to the distribution theory of non-negative random variables; the many examples used in the text, are introduced and discussed in light of theoretical perspectives. The book is organized into 9 chapters: The first motivates the presentation of the material on subsequent chapters; Chapter 2-3 provides a review of basic concepts of probability and statistical models for the distributions of continuous lifetime data and the distributions of random counts and counting processes, which are linked to phenomenological models. Chapters 4 focuses on dynamic behaviors of a disease outbreak during the initial phase while Chapters 5-6 broadly cover compartment models to investigate the consequences of epidemics as the outbreak moves beyond the initial phase. Chapter 7 provides a transition between mostly theoretical topics in earlier chapters and Chapters 8 and 9 where the focus is on the data generating processes and statistical issues of fitting models to data as well as specific mathematical epidemic modeling applications, respectively. This book is aimed at a wide audience ranging from graduate students to established scientists from quantitatively-oriented fields of epidemiology, mathematics and statistics. The numerous examples and illustrations make understanding of the mathematics of disease transmission and control accessible. Furthermore, the examples and exercises, make the book suitable for motivated students in applied mathematics, either through a lecture course, or through self-study. This text could be used in graduate schools or special summer schools covering research problems in mathematical biology.

This book is intended for the practicing surgeon. It is designed to offer practical insights into the essentials of an epidemiological, statistical and outcomes-based approach to surgical practice. Surgeons are invited to begin to develop the requisite skills that will allow them to communicate effectively with their colleagues in epidemiology and

'This very informative book introduces classical and novel statistical methods that can be used by theoretical and applied biostatisticians to develop efficient solutions for real-world problems encountered in clinical trials and epidemiological studies. The authors provide a detailed discussion of methodological and applied issues in parametric, semi-parametric and nonparametric approaches, including computationally extensive data-driven techniques, such as empirical likelihood, sequential procedures, and bootstrap methods. Many of these techniques are implemented using popular software such as R and SAS.'— Vlad Dragalin, Professor, Johnson and Johnson, Spring House, PA'It is always a pleasure to come across a new book that covers nearly all facets of a branch of science one thought was so broad, so diverse, and so dynamic that no single book could possibly hope to capture all of the fundamentals as well as directions of the field. The topics within the book's purview—fundamentals of measure-theoretic probability; parametric and non-parametric statistical inference; central limit theorems; basics of martingale theory; Monte Carlo methods; sequential analysis; sequential change-point detection—are all covered with inspiring clarity and precision. The authors are also very thorough and avail themselves of the most recent scholarship. They provide a detailed account of the state of the art, and bring together results that were previously scattered across disparate disciplines. This makes the book more than just a textbook: it is a panoramic companion to the field of Biostatistics. The book is self-contained, and the concise but careful exposition of material makes it accessible to a wide audience. This is appealing to graduate students interested in getting into the field, and also to professors looking to design a course on the subject.'— Aleksey S. Polunchenko, Department of Mathematical Sciences, State University of New York at BinghamtonThis book should be appropriate for use both as a text and as a reference. This book delivers a'ready-to-go'well-structured product to be employed in developing advanced courses. In this book the readers can find classical and new theoretical methods, open problems and new procedures.The book presents biostatistical results that are novel to the current set of books on the market and results that are even new with respect to the modern scientific literature. Several of these results can be found only in this book.

Analysis of Correlated Data with SAS and R: 4th edition presents an applied treatment of recently developed statistical models and methods for the analysis of hierarchical binary, count and continuous response data. It explains how to use procedures in SAS and packages in R for exploring data, fitting appropriate models, presenting programming codes and results.The book is designed for senior undergraduate and graduate students in the health sciences, epidemiology, statistics, and biostatistics as well as clinical researchers, and consulting statisticians who can apply the methods with their own data analyses. In each chapter a brief description of the foundations of statistical theory needed to understand the methods is given, thereafter the author illustrates the applicability of the techniques by providing sufficient number of examples. The last three chapters of the 4th edition contain introductory material on propensity score analysis, meta-analysis and the treatment of missing data using SAS and R. These topics were not covered in previous editions. The main reason is that there is an increasing demand by clinical researchers to have these topics covered at a reasonably understandable level of complexity. Mohamed Shoukri is principal scientist and professor of biostatistics at The National Biotechnology Center, King Faisal Specialist Hospital and Research Center and Al-Faisal University, Saudi Arabia. Professor Shoukri's research includes analytic epidemiology, analysis of hierarchical data, and clinical biostatistics. He is an associate editor of the 3Biotech journal, a Fellow of the Royal Statistical Society and an elected member of the International Statistical Institute.

Handbook of Statistical Methods for Case-Control Studies is written by leading researchers in the field. It provides an in-depth treatment of up-to-date and currently developing statistical methods for the design and analysis of case-control studies, as well as a review of classical principles and methods. The handbook is designed to serve as a reference text for biostatisticians and quantitatively-oriented epidemiologists who are working on the design and analysis of case-control studies or on related statistical methods research. Though not specifically intended as a textbook, it may also be used as a backup reference text for graduate level courses. Book Sections Classical designs and causal inference, measurement error, power, and small-sample inference Designs that use full-cohort information Time-to-event data Genetic epidemiology About the EditorsØrnulf Borgan is Professor of Statistics, University of Oslo. His book with Andersen, Gill and Keiding on counting processes in survival analysis is a world classic.Norman E. Breslow was, at the time of his death, Professor Emeritus in Biostatistics, University of Washington. For decades, his book with Nick Day has been the authoritative text on case-control methodology.Nilanjan Chatterjee is Bloomberg Distinguished Professor, Johns Hopkins University. He leads a broad research program in statistical methods for modern large scale biomedical studies. Mitchell H. Gail is a Senior Investigator at the National Cancer Institute. His research includes modeling absolute risk of disease, intervention trials, and statistical methods for epidemiology.Alastair Scott was, at the time of his death, Professor Emeritus of Statistics, University of Auckland. He was a major contributor to using survey sampling methods for analyzing case-control data.Chris J. Wild is Professor of Statistics, University of Auckland. His research includes nonlinear regression and methods for fitting models to response-selective data.

Mankind now faces even more challenging environment- and health-related problems than ever before. Readily available transportation systems facilitate the swift spread of diseases as large populations migrate from one part of the world to another. Studies on the spread of the communicable diseases are very important. This book, Mathematical Population Dynamics and Epidemiology in Temporal and Spatio-Temporal Domains, provides a useful experimental tool for making practical predictions, building and testing theories, answering specific questions, determining sensitivities of the parameters, forming control strategies, and much more. This volume focuses on the study of population dynamics with special emphasis on the migration of populations and the spreading of epidemics among human and animal populations. It also provides the background needed to interpret, construct, and analyze a wide variety of mathematical models. Most of the techniques presented in the book can be readily applied to model other phenomena, in biology as well as in other disciplines.

Since the publication of the second edition, many new Bayesian tools and methods have been developed for space-time data analysis, the predictive modeling of health outcomes, and other spatial biostatistical areas. Exploring these new developments, Bayesian Disease Mapping: Hierarchical Modeling in Spatial Epidemiology, Third Edition provides an up-to-date, cohesive account of the full range of Bayesian disease mapping methods and applications. In addition to the new material, the book also covers more conventional areas such as relative risk estimation, clustering, spatial survival analysis, and longitudinal analysis. After an introduction to Bayesian inference, computation, and model assessment, the text focuses on important themes, including disease map reconstruction, cluster detection, regression and ecological analysis, putative hazard modeling, analysis of multiple scales and multiple diseases, spatial survival and longitudinal studies, spatiotemporal methods, and map surveillance. It shows how Bayesian disease mapping can yield significant insights into georeferenced health data. The target audience for this text is public health specialists, epidemiologists, and biostatisticians who need to work with geo-referenced health data.

Disease Modelling and Public Health, Part A, Volume 36 addresses new challenges in existing and emerging diseases with a variety of comprehensive chapters that cover Infectious Disease Modeling, Bayesian Disease Mapping for Public Health, Real time estimation of the case fatality ratio and risk factor of death, Alternative Sampling Designs for Time-To-Event Data with Applications to Biomarker Discovery in Alzheimer's Disease, Dynamic risk prediction for cardiovascular disease: An illustration using the ARIC Study, Theoretical advances in type 2 diabetes, Finite Mixture Models in Biostatistics, and Models of Individual and Collective Behavior for Public Health Epidemiology. As a two part volume, the series covers an extensive range of techniques in the field. It present a vital resource for statisticians who need to access a number of different methods for assessing epidemic spread in population, or in formulating public health policy. - Presents a comprehensive, two-part volume written by leading subject experts - Provides a unique breadth and depth of content coverage - Addresses the most cutting-edge developments in the field - Includes chapters on Ebola and the Zika virus; topics which have grown in prominence and scholarly output

Cartographies of Disease: Maps, Mapping, and Medicine, new expanded edition, is a comprehensive survey of the technology of mapping and its relationship to the battle against disease. This look at medical mapping advances the argument that maps are not merely representations of spatial realities but a way of thinking about relationships between viral and bacterial communities, human hosts, and the environments in which diseases flourish. Cartographies of Disease traces the history of medical mapping from its growth in the 19th century during an era of trade and immigration to its renaissance in the 1990s during a new era of globalization. Referencing maps older than John Snow's famous cholera maps of London in the mid-19th century, this survey pulls from the plague maps of the 1600s, while addressing current issues concerning the ability of GIS technology to track diseases worldwide. The original chapters have some minor updating, and two new chapters have been added. Chapter 13 attempts to understand how the hundreds of maps of Ebola revealed not simply disease incidence but the way in which the epidemic itself was perceived. Chapter 14 is about the spatiality of the disease and the means by which different cartographic approaches may affect how infectious outbreaks like ebola can be confronted and contained.

Las matemáticas son una poderosa herramienta que permite entender cómo se propaga una enfermedad y cómo podemos ponerle freno. Sus modelos, simples y bellos, nos conducen a conclusiones indiscutibles y objetivas acerca del desarrollo de las enfermedades infecciosas y de la importancia de la vacunación. A través de la obra de Enrique F. Borja y Clara Grima, aprenderás de forma amena y cercana el potencial de las matemáticas en el control y prevención de epidemias. Descubrirás que, vigilantes de nuestra salud, pueden salvarnos la vida.

Handbook of Statistics: Disease Modelling and Public Health, Part B, Volume 37 addresses new challenges in existing and emerging diseases. As a two part volume, this title covers an extensive range of techniques in the field, with this book including chapters on Reaction diffusion equations and their application on bacterial communication, Spike and slab methods in disease modeling, Mathematical modeling of mass screening and parameter estimation, Individual-based and agent-based models for infectious disease transmission and evolution: an overview, and a section on Visual Clustering of Static and Dynamic High Dimensional Data. This volume covers the lack of availability of complete data relating to disease symptoms and disease epidemiology, one of the biggest challenges facing vaccine developers, public health planners, epidemiologists and health sector researchers. - Presents a comprehensive, two-part volume written by leading subject experts - Provides a unique breadth and depth of content coverage - Addresses the most cutting-edge developments in the field

With the many advances in the control of infectious disease over the last 100 years, the role of epidemiology in public health has transformed significantly. Epidemiologic research now includes the study of acute and chronic diseases, as well as the events, behaviors, and conditions associated with health. From seasoned author Ray Merrill, this text explores how epidemiologic methods are conducted and interpreted. In four sections, Statistical Methods in Epidemiologic Research covers basic concepts in epidemiology and statistics, study designs, statistical techniques and applications, as well as special topics. Key Features: • Includes sections on how specific epidemiologic methods have resulted in findings that have influenced health policy and public health • Offers optional sections involving more advanced methods • At the end of each chapter, an applications section gives the student a clear picture of how epidemiologic methods are applied in real-world situations • Special emphasis is given to interpreting results • SAS code is presented in an appendix that corresponds to assessing selected methods.

Dynamical Biostatistical Models presents statistical models and methods for the analysis of longitudinal data. The book focuses on models for analyzing repeated measures of quantitative and qualitative variables and events history, including survival and multistate models. Most of the advanced methods, such as multistate and joint models, can be ap

The contributions by epidemic modeling experts describe how mathematical models and statistical forecasting are created to capture the most important aspects of an emerging epidemic.Readers will discover a broad range of approaches to address questions, such asCan we control Ebola via ring vaccination strategies?How quickly should we detect Ebola cases to ensure epidemic control? What is the likelihood that an Ebola epidemic in West Africa leads to secondary outbreaks in other parts of the world? When does it matter to incorporate the role of disease-induced mortality on epidemic models? What is the role of behavior changes on Ebola dynamics? How can we better understand the control of cholera or Ebola using optimal control theory?How should a population be structured in order to mimic the transmission dynamics of diseases such as chlamydia, Ebola, or cholera?How can weobjectively determine the end of an epidemic?How can we use metapopulation models to understand the role of movement restrictions and migration patterns on the spread of infectious diseases?How can we capture the impact of household transmission using compartmental epidemic models?How could behavior-dependent vaccination affect the dynamical outcomes of epidemic models? The derivation and analysis of the mathematical models addressing these questions provides a wide-ranging overview of the new approaches being created to better forecast and mitigate emerging epidemics. This book will be of interest to researchers in the field of mathematical epidemiology, as well as public health workers.

Since the publication of the first edition, Biostatistics and Epidemiology has attracted loyal readers from across specialty areas in the biomedical community. Not only does this textbook teach foundations of epidemiological design and statistical methods, but it also includes topics applicable to new areas of research. Areas covered in the fourth edition include a new chapter on risk prediction, risk reclassification and evaluation of biomarkers, new material on propensity analyses, and a vastly expanded chapter on genetic epidemiology, which is particularly relevant to those who wish to understand the epidemiological and statistical aspects of scientific articles in this rapidly advancing field. Biostatistics and Epidemiology was written to be accessible for readers without backgrounds in mathematics. It provides clear explanations of underlying principles, as well as practical guidelines of'how to do it'and'how to interpret it.'Key features include a philosophical and logical explanation at the beginning of the book, subsections that can stand alone or serve as reference, cross-referencing, recommended reading, and appendices covering sample calculations for various statistics in the text.

Clinical research is a different ball game but is not a rocket science. A lot of young doctors and students tend to get intimidated with epidemiology and biostatistics. The very purpose of this text book is to narrate in a very simple language the basic concepts of epidemiology and biostatistics. The book has placed equal emphasis over both epidemiology and biostatistics part. In the epidemiology portion, attempt has been made to orient the reader with the importance of research, understanding of study design, measures of associations, measures of disease frequency, bias and confounding, concept of screening technique, skills of developing research protocol, data collection, ethical considerations, developing informed consent form and reference writing. In the biostatistics part, the reader will be explained the key concepts of sampling procedure, hypothesis testing, measures of central tendency, variables and data types, sample size estimation and data analysis plan. An attempt has been made to present the information in pictorial and tabular forms, which are easy to understand and retain. Moreover, to clear the concepts multiple examples are given so that the learner could easily understand the key concepts. It has been noted that the postgraduate trainee face difficulty in drafting a research protocol, conducting research and writing a dissertation. Thus, a detailed description of components of Research protocol and dissertation writing has been included in this book.

Written by a biostatistics expert with over 20 years of experience in the field, Bayesian Methods in Epidemiology presents statistical methods used in epidemiology from a Bayesian viewpoint. It employs the software package WinBUGS to carry out the analyses and offers the code in the text and for download online.The book examines study designs that

This book discusses the most important techniques available for longitudinal data analysis, from simple techniques such as the paired t-test and summary statistics, to more sophisticated ones such as generalized estimating of equations and mixed model analysis. A distinction is made between longitudinal analysis with continuous, dichotomous and categorical outcome variables. The emphasis of the discussion lies in the interpretation and comparison of the results of the different techniques. The second edition includes new chapters on the role of the time variable and presents new features of longitudinal data analysis. Explanations have been clarified where necessary and several chapters have been completely rewritten. The analysis of data from experimental studies and the problem of missing data in longitudinal studies are discussed. Finally, an extensive overview and comparison of different software packages is provided. This practical guide is essential for non-statisticians and researchers working with longitudinal data from epidemiological and clinical studies.

Biostatistics and Epidemiology: A Primer for Health Professionals focuses on the underlying framework of the field and offers practical guidelines for research and interpretation. In addition to major sections devoted to statistics and epidemiology, the book includes a comprehensive exploration of the scientific method, probability, and clinical trials. New to the second edition are: -a reorganization of the material -new information on survival analysis such as the Cox proportional hazards model -topics in nonparametric statistics -expanded discussion of probability and its applications in epidemiology -an entirely new chapter on areas relevant to behavioral research and change scores, reliability, validity, and responsiveness -new appendices providing specific and clear instructions on how to carry out several additional statistical calculations and tests Biostatistics and Epidemiology describes principles and methods applicable to medicine, public health, allied health, psychology and education and will be useful not only to physicians doing clinical as well as basic science research, but also to students at undergraduate, graduate and medical school levels.

This self-contained account of the statistical basis of epidemiology has been written specifically for those with a basic training in biology, therefore no previous knowledge is assumed and the mathematics is deliberately kept at a manageable level. The authors show how all statistical analysis of data is based on probability models, and once one understands the model, analysis follows easily. In showing how to use models in epidemiology the authors have chosen to emphasize the role of likelihood, an approach to statistics which is both simple and intuitively satisfying. More complex problems can then be tackled by natural extensions of the simple methods. Based on a highly successful course, this book explains the essential statistics for all epidemiologists.

Since the publication of the first edition, many new Bayesian tools and methods have been developed for space-time data analysis, the predictive modeling of health outcomes, and other spatial biostatistical areas. Exploring these new developments, Bayesian Disease Mapping: Hierarchical Modeling in Spatial Epidemiology, Second Edition provides an up-to-date, cohesive account of the full range of Bayesian disease mapping methods and applications. A biostatistics professor and WHO advisor, the author illustrates the use of Bayesian hierarchical modeling in the geographical analysis of disease through a range of real-world datasets. New to the Second Edition Three new chapters on regression and ecological analysis, putative hazard modeling, and disease map surveillance Expanded material on case event modeling and spatiotemporal analysis New and updated examples Two new appendices featuring examples of integrated nested Laplace approximation (INLA) and conditional autoregressive (CAR) models In addition to these new topics, the book covers more conventional areas such as relative risk estimation, clustering, spatial survival analysis, and longitudinal analysis. After an introduction to Bayesian inference, computation, and model assessment, the text focuses on important themes, including disease map reconstruction, cluster detection, regression and ecological analysis, putative hazard modeling, analysis of multiple scales and multiple diseases, spatial survival and longitudinal studies, spatiotemporal methods, and map surveillance. It shows how Bayesian disease mapping can yield significant insights into georeferenced health data. WinBUGS and R are used throughout for data manipulation and simulation.

While biomedical researchers may be able to follow instructions in the manuals accompanying the statistical software packages, they do not always have sufficient knowledge to choose the appropriate statistical methods and correctly interpret their results. Statistical Thinking in Epidemiology examines common methodological and statistical problems

The present lecture notes describe stochastic epidemic models and methods for their statistical analysis. Our aim is to present ideas for such models, and methods for their analysis; along the way we make practical use of several probabilistic and statistical techniques. This will be done without focusing on any specific disease, and instead rigorously analyzing rather simple models. The reader of these lecture notes could thus have a two-fold purpose in mind: to learn about epidemic models and their statistical analysis, and/or to learn and apply techniques in probability and statistics. The lecture notes require an early graduate level knowledge of probability and They introduce several techniques which might be new to students, but our statistics. intention is to present these keeping the technical level at a minlmum. Techniques that are explained and applied in the lecture notes are, for example: coupling, diffusion approximation, random graphs, likelihood theory for counting processes, martingales, the EM-algorithm and MCMC methods. The aim is to introduce and apply these techniques, thus hopefully motivating their further theoretical treatment. A few sections, mainly in Chapter 5, assume some knowledge of weak convergence; we hope that readers not familiar with this theory can understand the these parts at a heuristic level. The text is divided into two distinct but related parts: modelling and estimation.

Mathematical epidemiology of infectious diseases usually involves describing the flow of individuals between mutually exclusive infection states. One of the key parameters describing the transition from the susceptible to the infected class is the hazard of infection, often referred to as the force of infection. The force of infection reflects the degree of contact with potential for transmission between infected and susceptible individuals. The mathematical relation between the force of infection and effective contact patterns is generally assumed to be subjected to the mass action principle, which yields the necessary information to estimate the basic reproduction number, another key parameter in infectious disease epidemiology. It is within this context that the Center for Statistics (CenStat, I-Biostat, Hasselt University) and the Centre for the Evaluation of Vaccination and the Centre for Health Economic Research and Modelling Infectious Diseases (CEV, CHERMID, Vaccine and Infectious Disease Institute, University of Antwerp) have collaborated over the past 15 years. This book demonstrates the past and current research activities of these institutes and can be considered to be a milestone in this collaboration. This book is focused on the application of modern statistical methods and models to estimate infectious disease parameters. We want to provide the readers with software guidance, such as R packages, and with data, as far as they can be made publicly available.

Routine applications of advanced statistical methods on real data have become possible in the last ten years because desktop computers have become much more powerful and cheaper. However, proper understanding of the challenging statistical theory behind those methods remains essential for correct application and interpretation, and rarely seen in the medical literature. Modern Methods for Epidemiology provides a concise introduction to recent development in statistical methodologies for epidemiological and biomedical researchers. Many of these methods have become indispensible tools for researchers working in epidemiology and medicine but are rarely discussed in details by standard textbooks of biostatistics or epidemiology. Contributors of this book are experienced researchers and experts in their respective fields. This textbook provides a solid starting point for those who are new to epidemiology, and for those looking for guidance in more modern statistical approaches to observational epidemiology. Epidemiological and biomedical researchers who wish to overcome the mathematical barrier of applying those methods to their research will find this book an accessible and helpful reference for self-learning and research. This book is also a good source for teaching postgraduate students in medical statistics or epidemiology.

In this innovative new book, Steve Selvin provides readers with a clear understanding of intermediate biostatistical methods without advanced mathematics or statistical theory (for example, no Bayesian statistics, no causal inference, no linear algebra and only a slight hint of calculus). This text answers the important question: After a typical first-year course in statistical methods, what next? Statistical Tools for Epidemiologic Research thoroughly explains not just how statistical data analysis works, but how the analysis is accomplished. From the basic foundation laid in the introduction, chapters gradually increase in sophistication with particular emphasis on regression techniques (logistic, Poisson, conditional logistic and log-linear) and then beyond to useful techniques that are not typically discussed in an applied context. Intuitive explanations richly supported with numerous examples produce an accessible presentation for readers interested in the analysis of data relevant to epidemiologic or medical research.

A collection of highly valuable statistical and computational approaches designed for developing powerful methods to analyze large-scale high-throughput data derived from studies of complex diseases. Such diseases include cancer and cardiovascular disease, and constitute the major health challenges in industrialized countries. They are characterized by the systems properties of gene networks and their interrelations, instead of individual genes, whose malfunctioning manifests in pathological phenotypes, thus making the analysis of the resulting large data sets particularly challenging. This is why novel approaches are needed to tackle this problem efficiently on a systems level. Written by computational biologists and biostatisticians, this book is an invaluable resource for a large number of researchers working on basic but also applied aspects of biomedical data analysis emphasizing the pathway level.

This book is intended to provide a text on statistical methods for detecting clus ters and/or clustering of health events that is of interest to?nal year undergraduate and graduate level statistics, biostatistics, epidemiology, and geography students but will also be of relevance to public health practitioners, statisticians, biostatisticians, epidemiologists, medical geographers, human geographers, environmental scien tists, and ecologists. Prerequisites are introductory biostatistics and epidemiology courses. With increasing public health concerns about environmental risks, the need for sophisticated methods for analyzing spatial health events is immediate. Further more, the research area of statistical tests for disease clustering now attracts a wide audience due to the perceived need to implement wide ranging monitoring systems to detect possible health related bioterrorism activity. With this background and the development of the geographical information system (GIS), the analysis of disease clustering of health events has seen considerable development over the last decade. Therefore, several excellent books on spatial epidemiology and statistics have re cently been published. However, it seems to me that there is no other book solely focusing on statistical methods for disease clustering. I hope that readers will?nd this book useful and interesting as an introduction to the subject.

Preeminent Experts Update a Well-Respected BookTaking into account the regulatory and scientific developments that have occurred since the second edition, Design and Analysis of Bioavailability and Bioequivalence Studies, Third Edition provides a complete presentation of the latest progress of activities and results in bioavailability and bioequiva

Mathematical and Statistical Estimation Approaches in Epidemiology compiles t- oretical and practical contributions of experts in the analysis of infectious disease epidemics in a single volume. Recent collections have focused in the analyses and simulation of deterministic and stochastic models whose aim is to identify and rank epidemiological and social mechanisms responsible for disease transmission. The contributions in this volume focus on the connections between models and disease data with emphasis on the application of mathematical and statistical approaches that quantify model and data uncertainty. The book is aimed at public health experts, applied mathematicians and sci- tists in the life and social sciences, particularly graduate or advanced undergraduate students, who are interested not only in building and connecting models to data but also in applying and developing methods that quantify uncertainty in the context of infectious diseases. Chowell and Brauer open this volume with an overview of the classical disease transmission models of Kermack-McKendrick including extensions that account for increased levels of epidemiological heterogeneity. Their theoretical tour is followed by the introduction of a simple methodology for the estimation of, the basic reproduction number,R. The use of this methodology 0 is illustrated, using regional data for 1918–1919 and 1968 in uenza pandemics.

Focusing on data commonly found in public health databases and clinical settings, Bayesian Disease Mapping: Hierarchical Modeling in Spatial Epidemiology provides an overview of the main areas of Bayesian hierarchical modeling and its application to the geographical analysis of disease. The book explores a range of topics in Bayesian inference and