1. Evaluation of Substituted Pyrazole-Based Kinase Inhibitors in One Decade (2011-2020): Current Status and Future Prospects.
- Author
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El-Gamal MI, Zaraei SO, Madkour MM, and Anbar HS
- Subjects
- Anti-Inflammatory Agents chemistry, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents therapeutic use, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Antineoplastic Agents therapeutic use, Apoptosis drug effects, Biomarkers, Tumor, Drug Development history, Enzyme Inhibitors classification, Enzyme Inhibitors therapeutic use, History, 21st Century, Humans, Immune Checkpoint Inhibitors chemistry, Immune Checkpoint Inhibitors pharmacology, Models, Molecular, Protein Kinase Inhibitors chemistry, Protein Kinase Inhibitors pharmacology, Protein Kinase Inhibitors therapeutic use, Pyrazoles therapeutic use, Signal Transduction drug effects, Structure-Activity Relationship, Drug Development methods, Drug Development trends, Enzyme Inhibitors chemistry, Enzyme Inhibitors pharmacology, Pyrazoles chemistry, Pyrazoles pharmacology
- Abstract
Pyrazole has been recognized as a pharmacologically important privileged scaffold whose derivatives produce almost all types of pharmacological activities and have attracted much attention in the last decades. Of the various pyrazole derivatives reported as potential therapeutic agents, this article focuses on pyrazole-based kinase inhibitors. Pyrazole-possessing kinase inhibitors play a crucial role in various disease areas, especially in many cancer types such as lymphoma, breast cancer, melanoma, cervical cancer, and others in addition to inflammation and neurodegenerative disorders. In this article, we reviewed the structural and biological characteristics of the pyrazole derivatives recently reported as kinase inhibitors and classified them according to their target kinases in a chronological order. We reviewed the reports including pyrazole derivatives as kinase inhibitors published during the past decade (2011-2020).
- Published
- 2022
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