173 results on '"Entz-Werlé, Natacha"'
Search Results
2. Clinical impact of large genomic explorations at diagnosis in 198 pediatric solid tumors: a monocentric study aiming practical feasibility of precision oncology
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Simon, Juliette, Reita, Damien, Guerin, Eric, Lhermitte, Benoit, Weingertner, Noelle, Lefebvre, François, Karanian, Marie, Masliah-Planchon, Julien, Lindner, Veronique, Onea, Alina, Jannier, Sarah, Salmon, Alexandra, Bergthold, Guillaume, Vincent, Florence, Deschuyter, Marlène, Barbaza, Marie-Odile, and Entz-Werlé, Natacha
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- 2024
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3. Hypoxia-driven heterogeneous expression of α5 integrin in glioblastoma stem cells is linked to HIF-2α
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Messé, Mélissa, Bernhard, Chloé, Foppolo, Sophie, Thomas, Lionel, Marchand, Patrice, Herold-Mende, Christel, Idbaih, Ahmed, Kessler, Horst, Etienne-Selloum, Nelly, Ochoa, Charles, Tambar, Uttam K., Elati, Mohamed, Laquerriere, Patrice, Entz-Werle, Natacha, Martin, Sophie, Reita, Damien, and Dontenwill, Monique
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- 2024
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4. Overcoming the limits of pediatric brain tumor radiotherapy: The use of preclinical 3D models
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Czuba, Élodie, Deschuyter, Marlène, Entz-Werlé, Natacha, Noël, Georges, and Burckel, Hélène
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- 2024
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5. Chemo-immunotherapy with dinutuximab beta in patients with relapsed/progressive high-risk neuroblastoma: does chemotherapy backbone matter?
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Raiser, Patricia, Schleiermacher, Gudrun, Gambart, Marion, Dumont, Benoit, Defachelles, Anne-Sophie, Thebaud, Estelle, Tandonnet, Julie, Pasqualini, Claudia, Proust, Stéphanie, Entz-Werle, Natacha, Aerts, Isabelle, Ndounga-Diakou, Lee A., Petit, Arnaud, Puiseux, Chloe, Khanfar, Camille, Rouger, Jeremie, Mansuy, Ludovic, Benadiba, Joy, Millot, Frédéric, Pluchart, Claire, Laghouati, Salim, Geoerger, Birgit, Vassal, Gilles, Valteau-Couanet, Dominique, and Berlanga, Pablo
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- 2024
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6. Clinical trial inclusion in patients with relapsed/refractory neuroblastoma following the European Precision Cancer Medicine trial MAPPYACTS
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Chaix, Jordane, Schleiermacher, Gudrun, Corradini, Nadège, André, Nicolas, Thebaud, Estelle, Gambart, Marion, Defachelles, Anne-Sophie, Entz-Werle, Natacha, Chastagner, Pascal, De Carli, Émilie, Ducassou, Stéphane, Landman-Parker, Judith, Adam-de-Beaumais, Tiphaine, Larive, Alicia, Michiels, Stefan, Vassal, Gilles, Valteau-Couanet, Dominique, Geoerger, Birgit, and Berlanga, Pablo
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- 2024
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7. A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors
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Marques Da Costa, Maria Eugénia, Zaidi, Sakina, Scoazec, Jean-Yves, Droit, Robin, Lim, Wan Ching, Marchais, Antonin, Salmon, Jerome, Cherkaoui, Sarah, Morscher, Raphael J., Laurent, Anouchka, Malinge, Sébastien, Mercher, Thomas, Tabone-Eglinger, Séverine, Goddard, Isabelle, Pflumio, Francoise, Calvo, Julien, Redini, Francoise, Entz-Werlé, Natacha, Soriano, Aroa, Villanueva, Alberto, Cairo, Stefano, Chastagner, Pascal, Moro, Massimo, Owens, Cormac, Casanova, Michela, Hladun-Alvaro, Raquel, Berlanga, Pablo, Daudigeos-Dubus, Estelle, Dessen, Philippe, Zitvogel, Laurence, Lacroix, Ludovic, Pierron, Gaelle, Delattre, Olivier, Schleiermacher, Gudrun, Surdez, Didier, and Geoerger, Birgit
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- 2023
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8. All pineal tumors expressing germ cell tumor markers are not necessarily germ cell tumors: histopathological and molecular study of a midline primary intracranial sarcoma DICER1-mutant
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Wolf, Thibaut, Coca, Andres Hugo, Weingertner, Noelle, Chenard, Marie Pierre, Meurgey, Alexandra, Reita, Damien, Pencreach, Erwan, Varlet, Pascale, Entz-Werlé, Natacha, and Lhermitte, Benoît
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- 2023
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9. Pediatric Tumors and Developmental Anomalies: A French Nationwide Cohort Study
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Semeraro, Michaela, Fouquet, Cyrielle, Vial, Yoann, Amiel, Jeanne, Galmiche, Louise, Cretolle, Célia, Blanc, Thomas, Jolaine, Valérie, Garcelon, Nicolas, Entz-Werle, Natacha, Pellier, Isabelle, Vérité, Cécile, Sophie Taque, Coulomb, Aurore, Petit, Arnaud, Corradini, Nadège, Bouazza, Naim, Lacour, Brigitte, Clavel, Jacqueline, Brugières, Laurence, Bourdeaut, Franck, and Sarnacki, Sabine
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- 2023
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10. Challenges in glioblastoma research: focus on the tumor microenvironment
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Bikfalvi, Andreas, da Costa, Cristine Alves, Avril, Tony, Barnier, Jean-Vianney, Bauchet, Luc, Brisson, Lucie, Cartron, Pierre Francois, Castel, Hélène, Chevet, Eric, Chneiweiss, Hervé, Clavreul, Anne, Constantin, Bruno, Coronas, Valérie, Daubon, Thomas, Dontenwill, Monique, Ducray, Francois, Entz-Werlé, Natacha, Figarella-Branger, Dominique, Fournier, Isabelle, Frenel, Jean-Sébastien, Gabut, Mathieu, Galli, Thierry, Gavard, Julie, Huberfeld, Gilles, Hugnot, Jean-Philippe, Idbaih, Ahmed, Junier, Marie-Pierre, Mathivet, Thomas, Menei, Philippe, Meyronet, David, Mirjolet, Céline, Morin, Fabrice, Mosser, Jean, Moyal, Elisabeth Cohen-Jonathan, Rousseau, Véronique, Salzet, Michel, Sanson, Marc, Seano, Giorgio, Tabouret, Emeline, Tchoghandjian, Aurélie, Turchi, Laurent, Vallette, Francois M., Vats, Somya, Verreault, Maité, and Virolle, Thierry
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- 2023
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11. Impact of pharmacogenetics on variability in exposure to oral vinorelbine among pediatric patients: a model‐based population pharmacokinetic analysis
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Hamimed, Mourad, Leblond, Pierre, Dumont, Aurélie, Gattacceca, Florence, Tresch-Bruneel, Emmanuelle, Probst, Alicia, Chastagner, Pascal, Pagnier, Anne, De Carli, Emilie, Entz-Werlé, Natacha, Grill, Jacques, Aerts, Isabelle, Frappaz, Didier, Bertozzi-Salamon, Anne-Isabelle, Solas, Caroline, André, Nicolas, and Ciccolini, Joseph
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- 2022
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12. An appraisal of the frequency and severity of noninfectious manifestations in primary immunodeficiencies: A study of a national retrospective cohort of 1375 patients over 10 years
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Abou-Chahla, Wadih, Adoue, Daniel, Aladjidi, Nathalie, Armari-Alla, Corinne, Barlogis, Vincent, Bayart, Sophie, Bertrand, Yves, Blanche, Stéphane, Bodet, Damien, Bonnotte, Bernard, Borie, Raphaël, Boutard, Patrick, Boutboul, David, Briandet, Claire, Brion, Jean-Paul, Brouard, Jacques, Carausu, Liana, Castelle, Martin, Cathebras, Pascal, Catherinot, Emilie, Cheikh, Nathalie, Cheminant, Morgane, Cohen-Beaussant, Sarah, Comont, Thibault, Couderc, Louis-Jean, Cougoul, Pierre, Couillault, Gérard, Crevon, Lionel, Demonchy, Elisa, Deville, Anne, Devoldere, Catherine, Dore, Eric, Dulieu, Fabienne, Durieu, Isabelle, Entz-Werle, Natacha, Fieschi, Claire, Fouyssac, Fanny, Frange, Pierre, Gajdos, Vincent, Galicier, Lionel, Gandemer, Virginie, Gardembas, Martine, Gaud, Catherine, Grosbois, Bernard, Guffroy, Aurélien, Guitton, Corinne, Guillerm, Gaëlle, Hachulla, Eric, Hamidou, Mohamed, Haro, Sophie, Hatchuel, Yves, Hermine, Olivier, Hoarau, Cyrille, Hot, Arnaud, Humbert, Sébastien, Jaccard, Arnaud, Jais, Jean-Philippe, Jannier, Sarah, Jacquot, Serge, Jaussaud, Roland, Jeandel, Pierre-Yves, Jeziorski, Eric, Kebaili, Kamila, Korganow, Anne-Sophie, Lambotte, Olivier, Lanternier, Fanny, Larroche, Claire, Launay, David, Le Moigne, Emmanuelle, Le Quellec, Alain, Le Moing, Vincent, Lebranchu, Yvon, Lecuit, Marc, Lefèvre, Guillaume, Lelièvre, Jean-Daniel, Lemal, Richard, Li-Thiao-Te, Valérie, Lortholary, Olivier, Luca, Luminita, Mallebranche, Coralie, Malphettes, Marion, Marie-Cardine, Aude, Martin-Silva, Nicolas, Masseau, Agathe, Mazingue, Françoise, Merlin, Etienne, Michel, Gérard, Millot, Frédéric, Miot, Charline, Monlibert, Béatrice, Monpoux, Fabrice, Moshous, Despina, Mouthon, Luc, Münzer, Martine, Navarro, Robert, Neven, Bénédicte, Nouar, Dalila, Nove-Josserand, Raphaële, Oksenhendler, Eric, Ouachée-Chardin, Marie, Pagnier, Anne, Pasquet, Marlène, Pellier, Isabelle, Perel, Yves, Perlat, Antoinette, Piguet, Christophe, Plantaz, Dominique, Rivière, Sophie, Roblot, Pascal, Rohrlich, Pierre-Simon, Royer, Bruno, Salle, Valéry, Sarrot-Reynauld, Françoise, Servettaz, Amélie, Stephan, Jean-Louis, Schleinitz, Nicolas, Sokol, Harry, Suarez, Felipe, Swiader, Laure, Taque, Sophie, Thomas, Caroline, Tournilhac, Olivier, Thumerelle, Caroline, Vannier, Jean-Pierre, Viallard, Jean-François, Alligon, Mickaël, Mahlaoui, Nizar, Courteille, Virginie, Costes, Laurence, Afonso, Veronica, Randrianomenjanahary, Philippe, de Vergnes, Nathalie, Ranohavimparany, Anja, Vo, Duy, Hafsa, Inès, Bach, Perrine, Benoit, Vincent, Garcelon, Nicolas, and Fischer, Alain
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- 2022
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13. Hematopoietic cell transplantation in severe combined immunodeficiency: The SCETIDE 2006-2014 European cohort
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Lankester, Arjan C., Neven, Benedicte, Mahlaoui, Nizar, von Asmuth, Erik G.J., Courteille, Virginie, Alligon, Mikael, Albert, Michael H., Serra, Isabelle Badell, Bader, Peter, Balashov, Dmitry, Beier, Rita, Bertrand, Yves, Blanche, Stephane, Bordon, Victoria, Bredius, Robbert G., Cant, Andrew, Cavazzana, Marina, Diaz-de-Heredia, Cristina, Dogu, Figen, Ehlert, Karoline, Entz-Werle, Natacha, Fasth, Anders, Ferrua, Francesca, Ferster, Alina, Formankova, Renata, Friedrich, Wilhelm, Gonzalez-Vicent, Marta, Gozdzik, Jolanta, Güngör, Tayfun, Hoenig, Manfred, Ikinciogullari, Aydan, Kalwak, Krzysztof, Kansoy, Savas, Kupesiz, Alphan, Lanfranchi, Arnalda, Lindemans, Caroline A., Meisel, Roland, Michel, Gerard, Miranda, Nuno A.A., Moraleda, Jose, Moshous, Despina, Pichler, Herbert, Rao, Kanchan, Sedlacek, Petr, Slatter, Mary, Soncini, Elena, Speckmann, Carsten, Sundin, Mikael, Toren, Amos, Vettenranta, Kim, Worth, Austen, Yeşilipek, Mehmet A., Zecca, Marco, Porta, Fulvio, Schulz, Ansgar, Veys, Paul, Fischer, Alain, and Gennery, Andrew R.
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- 2022
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14. Lenvatinib with etoposide plus ifosfamide in patients with refractory or relapsed osteosarcoma (ITCC-050): a multicentre, open-label, multicohort, phase 1/2 study
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Gaspar, Nathalie, Venkatramani, Rajkumar, Hecker-Nolting, Stefanie, Melcon, Soledad Gallego, Locatelli, Franco, Bautista, Francisco, Longhi, Alessandra, Lervat, Cyril, Entz-Werle, Natacha, Casanova, Michela, Aerts, Isabelle, Strauss, Sandra J, Thebaud, Estelle, Morland, Bruce, Nieto, Adela Cañete, Marec-Berard, Perrine, Gambart, Marion, Rossig, Claudia, Okpara, Chinyere E, He, Cixin, Dutta, Lea, and Campbell-Hewson, Quentin
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- 2021
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15. Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma viaaberrant expression of KCNN1/SK1 and dysregulation of calcium signaling
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Dupuy, Maryne, Gueguinou, Maxime, Postec, Anaïs, Brion, Régis, Tesfaye, Robel, Mullard, Mathilde, Regnier, Laura, Amiaud, Jérôme, Hubsch, Clémence, Potier-Cartereau, Marie, Chantôme, Aurélie, Brounais-Le Royer, Bénédicte, Baud’huin, Marc, Georges, Steven, Lamoureux, François, Ory, Benjamin, Entz-Werlé, Natacha, Delattre, Olivier, Rédini, Françoise, Vandier, Christophe, and Verrecchia, Franck
- Abstract
Ewing sarcoma (ES) is characterized by EWS::FLI1 or EWS::ERG fusion proteins. Knowing that ion channels are involved in tumorigenesis, this work aimed to study the involvement of the KCNN1gene, which encodes the SK1 potassium channel, in ES development. Bioinformatics analyses from databases were used to study KCNN1expression in patients and cell lines. Molecular approaches and in vitro assays were used to study the transcriptional regulation of KCNN1and its involvement in the regulation of ES cell proliferation. KCNN1is overexpressed in ES patient biopsies, and its expression is inversely correlated with patient survival. EWS::FLI1, like EWS::ERG, promotes KCNN1and SK1 expression, binding to GGAA microsatellites near the promoter of KCNN1isoforms. KCNN1is involved in the regulation of ES cell proliferation, with its silencing being associated with a slowing of the cell cycle, and its expression modulates membrane potential and therefore calcium flux. These results highlight that KCNN1is a direct target of EWS::FLI1 and EWS::ERG and demonstrate that KCNN1is involved in the regulation of intracellular calcium activity and ES cell proliferation, making it a promising therapeutic target in ES.
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- 2025
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16. Cabozantinib in patients with advanced Ewing sarcoma or osteosarcoma (CABONE): a multicentre, single-arm, phase 2 trial
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Italiano, Antoine, Mir, Olivier, Mathoulin-Pelissier, Simone, Penel, Nicolas, Piperno-Neumann, Sophie, Bompas, Emmanuelle, Chevreau, Christine, Duffaud, Florence, Entz-Werlé, Natacha, Saada, Esma, Ray-Coquard, Isabelle, Lervat, Cyril, Gaspar, Nathalie, Marec-Berard, Perrine, Pacquement, Hélène, Wright, John, Toulmonde, Maud, Bessede, Alban, Crombe, Amandine, Kind, Michèle, Bellera, Carine, and Blay, Jean-Yves
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- 2020
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17. Denosumab for treating aneurysmal bone cysts in children
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Raux, Sébastien, Bouhamama, Amine, Gaspar, Nathalie, Brugières, Laurence, Entz-Werlé, Natacha, Mallet, Cindy, Dijoud, Frédérique, Gouin, François, and Marec-Bérard, Perrine
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- 2019
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18. Intérêt du denosumab dans le traitement des kystes osseux anévrysmatiques de l’enfant
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Raux, Sébastien, Bouhamama, Amine, Gaspar, Nathalie, Brugières, Laurence, Entz-werlé, Natacha, Mallet, Cindy, Dijoud, Frédérique, Gouin, François, and Marec-Bérard, Perrine
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- 2019
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19. Targeting pediatric High-Grade Gliomas withOAcGD2-CAR Vδ2 T cells
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Thomas, Pauline, primary, Veerasamy, Maëva, additional, Devinat, Marine, additional, Guiet, Elodie, additional, Ollier, Jocelyn, additional, Paris, Pierre, additional, Entz-Werlé, Natacha, additional, Gratas, Catherine, additional, Clémenceau, Béatrice, additional, Birklé, Stéphane, additional, Paris, François, additional, Pecqueur, Claire, additional, and Fougeray, Sophie, additional
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- 2023
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20. MODL-22. DEVELOPMENT OF A PATIENT-DERIVED MODEL BIOBANK TO PROVIDE AN ACCURATE TOOL DECIPHERING BRAIN TUMOR INITIATION, PROGRESSION, AND THERAPEUTIC RESISTANCE
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Deschuyter, Marlène, primary, Wolf, Thibaut, additional, Lhermitte, Benoit, additional, Reita, Damien, additional, Fuchs, Quentin, additional, Pierrevelcin, Marina, additional, Foppolo, Sophie, additional, Dontenwill, Monique, additional, and Entz-Werlé, Natacha, additional
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- 2023
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21. Results of methotrexate-etoposide-ifosfamide based regimen (M-EI) in osteosarcoma patients included in the French OS2006/sarcome-09 study
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Gaspar, Nathalie, Occean, Bob-Valéry, Pacquement, Hélène, Bompas, Emmanuelle, Bouvier, Corine, Brisse, Hervé J., Castex, Marie-Pierre, Cheurfa, Nadir, Corradini, Nadège, Delaye, Jessy, Entz-Werlé, Natacha, Gentet, Jean-Claude, Italiano, Antoine, Lervat, Cyril, Marec-Berard, Perrine, Mascard, Eric, Redini, Françoise, Saumet, Laure, Schmitt, Claudine, Tabone, Marie-Dominique, Verite-Goulard, Cécile, Le Deley, Marie-Cécile, Piperno-Neumann, Sophie, and Brugieres, Laurence
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- 2018
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22. Autoimmune and inflammatory manifestations occur frequently in patients with primary immunodeficiencies
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Adoue, Daniel, Aladjidi, Nathalie, Amoura, Zahir, Arlet, Philippe, Armari-Alla, Corinne, Bader-Meunier, Brigitte, Barlogis, Vincent, Bayart, Sophie, Beaurain, Beatrice, Bertrand, Yves, Bienvenu, Boris, Blanche, Stéphane, Bodet, Damien, Bonnotte, Bernard, Borie, Raphaël, Boutard, Patrick, Briandet, Claire, Brion, Jean-Paul, Brito, Carolina, Brouard, Jacques, Catherinot, Emilie, Chandesris, Olivia, Cohen-Beaussant, Sarah, Coignard-Biehler, Hélène, Costes, Laurence, Couderc, Louis-Jean, Couillault, Gérard, Courteille, Virginie, Curlier, Elodie, de Saint Basile, Geneviève, Demeocq, François, de Vergnes, Nathalie, Devoldere, Catherine, Deville, Anne, Donadieu, Jean, Dore, Eric, Dulieu, Fabienne, Durieu, Isabelle, Edan, Christine, Entz Werle, Natacha, Fieschi, Claire, Fouyssac, Fanny, Frange, Pierre, Gajdos, Vincent, Galicier, Lionel, Gandemer, Virginie, Gardembas, Martine, Gaud, Catherine, Grosbois, Bernard, Guillerm, Gaelle, Hachulla, Eric, Hamidou, Mohamed, Héritier, Sébastien, Hermine, Olivier, Hoarau, Cyrille, Hoen, Bruno, Hot, Arnaud, Humbert, Sébastien, Jaccard, Arnaud, Jacquot, Serge, Jais, Jean-Philippe, Jaussaud, Rolland, Jeandel, Pierre-Yves, Jeziorski, Eric, Kebaili, Kamila, Korganow, Anne-Sophie, Labrune, Philippe, Lambotte, Olivier, Lanternier, Fanny, Larroche, Claire, Le Quellec, Alain, Le Moigne, Emmanuelle, Le Moing, Vincent, Lebranchu, Yvon, Lecuit, Marc, Lefevre, Guillaume, Lemal, Richard, Le Moine, Philippe, Li Thiao Te, Valérie, Lortholary, Olivier, Lutz, Patrick, Magerus-Chatinet, Aude, Malphettes, Marion, Marie-Cardine, Aude, Martin Silva, Nicolas, Masseau, Agathe, Massot, Christian, Mazingue, Françoise, Merlin, Etienne, Michel, Gérard, Millot, Frédéric, Minckes, Odile, Monlibert, Béatrice, Monpoux, Fabrice, Moshous, Despina, Mouthon, Luc, Munzer, Martine, Neven, Bénédicte, Nove-Josserand, Raphaëlle, Oksenhendler, Eric, Ouachée-Chardin, Marie, Pagnier, Anne, Pasquali, Jean-Louis, Pasquet, Marlène, Pellier, Isabelle, Perel, Yves, Perlat, Antoinette, Picard, Capucine, Piguet, Christophe, Plantaz, Dominique, Quartier, Pierre, Rieux-Laucat, Frédéric, Roblot, Pascal, Roger, Pierre-Marie, Rohrlich, Pierre-Simon, Royer, Bruno, Salle, Valéry, Sarrot-Reynauld, Françoise, Servettaz, Amélie, Stephan, Jean-Louis, Schleinitz, Nicolas, Suarez, Felipe, Swiader, Laure, Taque, Sophie, Thomas, Caroline, Tournilhac, Olivier, Thumerelle, Caroline, Vannier, Jean-Pierre, Viallard, Jean-François, Fischer, Alain, Provot, Johan, Alcais, Alexandre, and Mahlaoui, Nizar
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- 2017
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23. Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma
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Mackay, Alan, Burford, Anna, Carvalho, Diana, Izquierdo, Elisa, Fazal-Salom, Janat, Taylor, Kathryn R., Bjerke, Lynn, Clarke, Matthew, Vinci, Mara, Nandhabalan, Meera, Temelso, Sara, Popov, Sergey, Molinari, Valeria, Raman, Pichai, Waanders, Angela J., Han, Harry J., Gupta, Saumya, Marshall, Lynley, Zacharoulis, Stergios, Vaidya, Sucheta, Mandeville, Henry C., Bridges, Leslie R., Martin, Andrew J., Al-Sarraj, Safa, Chandler, Christopher, Ng, Ho-Keung, Li, Xingang, Mu, Kun, Trabelsi, Saoussen, Brahim, Dorra H’mida-Ben, Kisljakov, Alexei N., Konovalov, Dmitry M., Moore, Andrew S., Carcaboso, Angel Montero, Sunol, Mariona, de Torres, Carmen, Cruz, Ofelia, Mora, Jaume, Shats, Ludmila I., Stavale, João N., Bidinotto, Lucas T., Reis, Rui M., Entz-Werle, Natacha, Farrell, Michael, Cryan, Jane, Crimmins, Darach, Caird, John, Pears, Jane, Monje, Michelle, Debily, Marie-Anne, Castel, David, Grill, Jacques, Hawkins, Cynthia, Nikbakht, Hamid, Jabado, Nada, Baker, Suzanne J., Pfister, Stefan M., Jones, David T.W., Fouladi, Maryam, von Bueren, André O., Baudis, Michael, Resnick, Adam, and Jones, Chris
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- 2017
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24. Zoledronate in combination with chemotherapy and surgery to treat osteosarcoma (OS2006): a randomised, multicentre, open-label, phase 3 trial
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Piperno-Neumann, Sophie, Le Deley, Marie-Cécile, Rédini, Françoise, Pacquement, Hélène, Marec-Bérard, Perrine, Petit, Philippe, Brisse, Hervé, Lervat, Cyril, Gentet, Jean-Claude, Entz-Werlé, Natacha, Italiano, Antoine, Corradini, Nadège, Bompas, Emmanuelle, Penel, Nicolas, Tabone, Marie-Dominique, Gomez-Brouchet, Anne, Guinebretière, Jean-Marc, Mascard, Eric, Gouin, François, Chevance, Aurélie, Bonnet, Naïma, Blay, Jean-Yves, and Brugières, Laurence
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- 2016
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25. A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors
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Marques Da Costa, Maria Eugénia; https://orcid.org/0000-0002-1498-603X, Zaidi, Sakina; https://orcid.org/0000-0001-9128-0287, Scoazec, Jean-Yves; https://orcid.org/0000-0003-1604-6823, Droit, Robin, Lim, Wan Ching, Marchais, Antonin; https://orcid.org/0000-0003-0954-8294, Salmon, Jerome, Cherkaoui, Sarah, Morscher, Raphael J; https://orcid.org/0000-0003-3378-9266, Laurent, Anouchka, Malinge, Sébastien; https://orcid.org/0000-0002-9533-7778, Mercher, Thomas; https://orcid.org/0000-0003-1552-087X, Tabone-Eglinger, Séverine; https://orcid.org/0000-0003-4247-1321, Goddard, Isabelle, Pflumio, Francoise; https://orcid.org/0000-0001-8995-596X, Calvo, Julien; https://orcid.org/0000-0003-1316-4306, Redini, Francoise, Entz-Werlé, Natacha, Soriano, Aroa, Villanueva, Alberto; https://orcid.org/0000-0001-5164-0006, Cairo, Stefano, Chastagner, Pascal, Moro, Massimo; https://orcid.org/0000-0003-2562-4007, Owens, Cormac, Casanova, Michela, Hladun-Alvaro, Raquel, Berlanga, Pablo; https://orcid.org/0000-0003-1110-7789, Daudigeos-Dubus, Estelle; https://orcid.org/0000-0001-5065-5679, Dessen, Philippe, Surdez, Didier; https://orcid.org/0000-0002-7118-7859, et al, Marques Da Costa, Maria Eugénia; https://orcid.org/0000-0002-1498-603X, Zaidi, Sakina; https://orcid.org/0000-0001-9128-0287, Scoazec, Jean-Yves; https://orcid.org/0000-0003-1604-6823, Droit, Robin, Lim, Wan Ching, Marchais, Antonin; https://orcid.org/0000-0003-0954-8294, Salmon, Jerome, Cherkaoui, Sarah, Morscher, Raphael J; https://orcid.org/0000-0003-3378-9266, Laurent, Anouchka, Malinge, Sébastien; https://orcid.org/0000-0002-9533-7778, Mercher, Thomas; https://orcid.org/0000-0003-1552-087X, Tabone-Eglinger, Séverine; https://orcid.org/0000-0003-4247-1321, Goddard, Isabelle, Pflumio, Francoise; https://orcid.org/0000-0001-8995-596X, Calvo, Julien; https://orcid.org/0000-0003-1316-4306, Redini, Francoise, Entz-Werlé, Natacha, Soriano, Aroa, Villanueva, Alberto; https://orcid.org/0000-0001-5164-0006, Cairo, Stefano, Chastagner, Pascal, Moro, Massimo; https://orcid.org/0000-0003-2562-4007, Owens, Cormac, Casanova, Michela, Hladun-Alvaro, Raquel, Berlanga, Pablo; https://orcid.org/0000-0003-1110-7789, Daudigeos-Dubus, Estelle; https://orcid.org/0000-0001-5065-5679, Dessen, Philippe, Surdez, Didier; https://orcid.org/0000-0002-7118-7859, and et al
- Abstract
Pediatric patients with recurrent and refractory cancers are in most need for new treatments. This study developed patient-derived-xenograft (PDX) models within the European MAPPYACTS cancer precision medicine trial (NCT02613962). To date, 131 PDX models were established following heterotopical and/or orthotopical implantation in immunocompromised mice: 76 sarcomas, 25 other solid tumors, 12 central nervous system tumors, 15 acute leukemias, and 3 lymphomas. PDX establishment rate was 43%. Histology, whole exome and RNA sequencing revealed a high concordance with the primary patient's tumor profile, human leukocyte-antigen characteristics and specific metabolic pathway signatures. A detailed patient molecular characterization, including specific mutations prioritized in the clinical molecular tumor boards are provided. Ninety models were shared with the IMI2 ITCC Pediatric Preclinical Proof-of-concept Platform (IMI2 ITCC-P4) for further exploitation. This PDX biobank of unique recurrent childhood cancers provides an essential support for basic and translational research and treatments development in advanced pediatric malignancies.
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- 2023
26. Phase I Study of a Combination of Fluvastatin and Celecoxib in Children with Relapsing/Refractory Low-Grade or High-Grade Glioma (FLUVABREX)
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Leblond, Pierre, primary, Tresch-Bruneel, Emmanuelle, additional, Probst, Alicia, additional, Néant, Nadège, additional, Solas, Caroline, additional, Sterin, Arthur, additional, Boulanger, Thomas, additional, Aerts, Isabelle, additional, Faure-Conter, Cécile, additional, Bertozzi, Anne-Isabelle, additional, Chastagner, Pascal, additional, Entz-Werlé, Natacha, additional, De Carli, Emilie, additional, Deley, Marie-Cécile Le, additional, Bouche, Gauthier, additional, and André, Nicolas, additional
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- 2023
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27. p16 Immunohistochemical Expression as a Surrogate Assessment of CDKN2A Alteration in Gliomas Leading to Prognostic Significances
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Geyer, Lucas, primary, Wolf, Thibaut, additional, Chenard, Marie-Pierre, additional, Cebula, Helene, additional, Schott, Roland, additional, Noel, Georges, additional, Guerin, Eric, additional, Pencreach, Erwan, additional, Reita, Damien, additional, Entz-Werlé, Natacha, additional, and Lhermitte, Benoît, additional
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- 2023
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28. Molecular Heterogeneity in BRAF-Mutant Gliomas: Diagnostic, Prognostic, and Therapeutic Implications
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Lhermitte, Benoit, primary, Wolf, Thibaut, additional, Chenard, Marie Pierre, additional, Coca, Andres, additional, Todeschi, Julien, additional, Proust, François, additional, Hirsch, Edouard, additional, Schott, Roland, additional, Noel, Georges, additional, Guerin, Eric, additional, Reita, Damien, additional, Chammas, Agathe, additional, Salmon, Alexandra, additional, Martin, Sophie, additional, Dontenwill, Monique, additional, and Entz-Werlé, Natacha, additional
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- 2023
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29. Diagnosis of Constitutional Mismatch Repair-Deficiency Syndrome Based on Microsatellite Instability and Lymphocyte Tolerance to Methylating Agents
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Bodo, Sahra, Colas, Chrystelle, Buhard, Olivier, Collura, Ada, Tinat, Julie, Lavoine, Noémie, Guilloux, Agathe, Chalastanis, Alexandra, Lafitte, Philippe, Coulet, Florence, Buisine, Marie-Pierre, Ilencikova, Denisa, Ruiz-Ponte, Clara, Kinzel, Miriam, Grandjouan, Sophie, Brems, Hilde, Lejeune, Sophie, Blanché, Hélène, Wang, Qing, Caron, Olivier, Cabaret, Odile, Svrcek, Magali, Vidaud, Dominique, Parfait, Béatrice, Verloes, Alain, Knappe, Ulrich J., Soubrier, Florent, Mortemousque, Isabelle, Leis, Alexander, Auclair-Perrossier, Jessie, Frébourg, Thierry, Fléjou, Jean-François, Entz-Werle, Natacha, Leclerc, Julie, Malka, David, Cohen-Haguenauer, Odile, Goldberg, Yael, Gerdes, Anne-Marie, Fedhila, Faten, Mathieu-Dramard, Michèle, Hamelin, Richard, Wafaa, Badre, Gauthier-Villars, Marion, Bourdeaut, Franck, Sheridan, Eamonn, Vasen, Hans, Brugières, Laurence, Wimmer, Katharina, Muleris, Martine, and Duval, Alex
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- 2015
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30. All pineal tumors expressing germ cell tumor markers are not necessarily germ cell tumors: histopathological and molecular study of a midline primary intracranial sarcoma DICER1-mutant
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Wolf, Thibaut, primary, Coca, Andres Hugo, additional, Weingertner, Noelle, additional, Chenard, Marie Pierre, additional, Meurgey, Alexandra, additional, Reita, Damien, additional, Pencreach, Erwan, additional, Varlet, Pascale, additional, Entz-Werlé, Natacha, additional, and Lhermitte, Benoît, additional
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- 2022
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31. Engineering Novel 3D Models to Recreate High‐Grade Osteosarcoma and its Immune and Extracellular Matrix Microenvironment
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Pierrevelcin, Marina, primary, Flacher, Vincent, additional, Mueller, Christopher G., additional, Vauchelles, Romain, additional, Guerin, Eric, additional, Lhermitte, Benoît, additional, Pencreach, Erwan, additional, Reisch, Andreas, additional, Muller, Quentin, additional, Doumard, Layal, additional, Boufenghour, Wacym, additional, Klymchenko, Andrey S., additional, Foppolo, Sophie, additional, Nazon, Charlotte, additional, Weingertner, Noelle, additional, Martin, Sophie, additional, Briandet, Claire, additional, Laithier, Véronique, additional, Di Marco, Antonio, additional, Bund, Laurent, additional, Obrecht, Adeline, additional, Villa, Pascal, additional, Dontenwill, Monique, additional, and Entz‐Werlé, Natacha, additional
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- 2022
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32. Abstract 2022: Model-informed pediatric drug development: oral vinorelbine in low-grade glioma as a case study
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HAMIMED, Mourad, primary, LEBLOND, Pierre, additional, DUMONT, Aurélie, additional, GATTACCECA, Florence, additional, TRESCH-BRUNEEL, Emmanuelle, additional, PROBST, Alicia, additional, CHASTAGNER, Pascal, additional, PAGNIER, Anne, additional, CARLI, Emilie DE, additional, ENTZ-WERLÉ, Natacha, additional, GRILL, Jacques, additional, AERTS, Isabelle, additional, FRAPPAZ, Didier, additional, BERTOZZI-SALAMON, Anne-Isabelle, additional, SOLAS, Caroline, additional, ANDRÉ, Nicolas, additional, and Ciccolini, Joseph, additional
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- 2022
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33. LGG-16. Retrospective and integrative analyses of molecular characteristics and their specific imaging parameters in pediatric grade 1 gliomas.
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Courant, Marie, primary, Lhermitte, Benoit, additional, Guerin, Eric, additional, Chammas, Agathe, additional, Reita, Damien, additional, Sebastia, Consuelo, additional, Douzal, Valérie, additional, Gabor, Flaviu, additional, Salmon, Alexandra, additional, Todeschi, Julien, additional, Coca, Andres Hugo, additional, Vincent, Florence, additional, and Entz-Werlé, Natacha, additional
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- 2022
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34. HGG-52. Combinatorial modulation of hypoxic pathways leads to anti-tumoral effects in H3.3 K27M midline gliomas
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Fuchs, Quentin, primary, Lhermitte, Benoit, additional, Foppolo, Sophie, additional, Hubsch, Clemence, additional, Martin, Sophie, additional, Dontenwill, Monique, additional, and Entz-Werlé, Natacha, additional
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- 2022
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35. HGG-39. Integrative analyses of BRAFp.v600e mutated gliomas: from epigenetic to metabolic characteristics
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Lhermitte, Benoit, primary, Wolf, Thibault, additional, Namer, Izzie Jacques, additional, Bund, Caroline, additional, Fuchs, Quentin, additional, Dontenwill, Monique, additional, and Entz-Werlé, Natacha, additional
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- 2022
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36. Retrospective and integrative analyses of molecular characteristics and their specific imaging parameters in pediatric grade 1 gliomas
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Coutant, Marie, primary, Lhermitte, Benoit, additional, Guérin, Eric, additional, Chammas, Agathe, additional, Reita, Damien, additional, Sebastia, Consuelo, additional, Douzal, Valérie, additional, Gabor, Flaviu, additional, Salmon, Alexandra, additional, Chenard, Marie‐Pierre, additional, Todeschi, Julien, additional, Coca, Andres, additional, Heng, Marie‐Amelie, additional, Vincent, Florence, additional, and Entz‐Werlé, Natacha, additional
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- 2022
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37. Targeted Apc;Twist Double-Mutant Mice: A New Model of Spontaneous Osteosarcoma That Mimics the Human Disease
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Entz-Werlé, Natacha, Choquet, Philippe, Neuville, Agnès, Kuchler-Bopp, Sabine, Clauss, François, Danse, Jean-Marc, Simo-Noumbissie, Pauline, Guérin, Eric, Gaub, Marie-Pierre, Freund, Jean-Noel, Boehm, Nelly, Constantinesco, André, Lutz, Patrick, Guenot, Dominique, and Perrin-Schmitt, Fabienne
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- 2010
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38. Pharmacokinetics of oral vinorelbine in French children with recurrent or progressive primary low‐grade glioma
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Hamimed, Mourad, primary, Gattacceca, Florence, additional, André, Nicolas, additional, Tresch‐Bruneel, Emmanuelle, additional, Probst, Alicia, additional, Chastagner, Pascal, additional, Pagnier, Anne, additional, De Carli, Emilie, additional, Entz‐Werlé, Natacha, additional, Grill, Jacques, additional, Aerts, Isabelle, additional, Frappaz, Didier, additional, Bertozzi‐Salamon, Anne‐Isabelle, additional, Solas, Caroline, additional, and Leblond, Pierre, additional
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- 2021
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39. Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions
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Fuchs, Quentin, primary, Batut, Aurélie, primary, Gleyzes, Mélanie, primary, Rontard, Jessica, primary, Miny, Louise, primary, Libralato, Margot, primary, Vieira, Janaina, primary, Debis, Delphine, primary, Larramendy, Florian, primary, Honegger, Thibault, primary, Messe, Melissa, primary, Pierrevelcin, Marina, primary, Lhermitte, Benoit, primary, Dontenwill, Monique, primary, and Entz-Werlé, Natacha, primary
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- 2021
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40. Impact of Chromatin Dynamics and DNA Repair on Genomic Stability and Treatment Resistance in Pediatric High-Grade Gliomas
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Pinto, Lia, primary, Baidarjad, Hanane, additional, Entz-Werlé, Natacha, additional, and Van Dyck, Eric, additional
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- 2021
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41. Characterization of Macrophages and Osteoclasts in the Osteosarcoma Tumor Microenvironment at Diagnosis: New Perspective for Osteosarcoma Treatment?
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Gomez-Brouchet, Anne, Gilhodes, Julia, Acker, Nathalie Van, Brion, Regis, Bouvier, Corinne, Assemat, Pauline, Gaspar, Nathalie, Aubert, Sebastien, Guinebretiere, Jean-Marc, Marie, Beatrice, Larousserie, Frederique, Entz-Werlé, Natacha, de Pinieux, Gonzague, Mascard, Eric, Gouin, Francois, Brousset, Pierre, Tabone, Marie-Dominique, Jimenez, Marta, Le Deley, Marie-Cecile, Blay, Jean-Yves, Brugieres, Laurence, Piperno-Neumann, Sophie, Rédini, Francoise, Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Sarcomes osseux et remodelage des tissus calcifiés - Phy-Os [Nantes - INSERM U1238] (Phy-Os), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université Bretagne Loire (UBL), Hôpital de la Timone [CHU - APHM] (TIMONE), Institut de mécanique des fluides de Toulouse (IMFT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Institut Gustave Roussy (IGR), Université Paris-Saclay, Département de cancérologie de l'enfant et de l'adolescent [Gustave Roussy], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut Curie [Paris], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital de Hautepierre [Strasbourg], Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Léon Bérard [Lyon], Department of Radiology, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France, Département cancer environnement (Centre Léon Bérard - Lyon), University of Nantes, 44007 Nantes, France, Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), and Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
- Subjects
Osteosarcoma ,Bipotent macrophage ,Macrophage ,Immunothérapie ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,[SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy ,macrophage ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,lcsh:RC254-282 ,Article ,multiplex ,zoledronic acid ,bipotent macrophage ,osteosarcoma ,osteoclast ,Osteoclast ,Zoledronic acid ,Multiplex ,Cancer - Abstract
Biological and histopathological techniques identified osteoclasts and macrophages as targets of zoledronic acid (ZA), a therapeutic agent that was detrimental for patients in the French OS2006 trial. Conventional and multiplex immunohistochemistry of microenvironmental and OS cells were performed on biopsies of 124 OS2006 patients and 17 surgical (&ldquo, OSNew&rdquo, ) biopsies respectively. CSF-1R (common osteoclast/macrophage progenitor) and TRAP (osteoclast activity) levels in serum of 108 patients were correlated to response to chemotherapy and to prognosis. TRAP levels at surgery and at the end of the protocol were significantly lower in ZA+ than ZA&minus, patients (padj = 0.0011, 0.0132). For ZA+-patients, an increase in the CSF-1R level between diagnosis and surgery and a high TRAP level in the serum at biopsy were associated with a better response to chemotherapy (p = 0.0091, p = 0.0251). At diagnosis, high CD163+ was associated with good prognosis, while low TRAP activity was associated with better overall survival in ZA&minus, patients only. Multiplex immunohistochemistry demonstrated remarkable bipotent CD68+/CD163+ macrophages, homogeneously distributed throughout OS regions, aside osteoclasts (CD68+/CD163&minus, ) mostly residing in osteolytic territories and osteoid-matrix-associated CD68&minus, /CD163+ macrophages. We demonstrate that ZA not only acts on harmful osteoclasts but also on protective macrophages, and hypothesize that the bipotent CD68+/CD163+ macrophages might present novel therapeutic targets.
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- 2021
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42. A DNA Repair and Cell Cycle Gene Expression Signature in Pediatric High-Grade Gliomas: Prognostic and Therapeutic Value
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Entz-Werlé, Natacha, primary, Poidevin, Laetitia, additional, Nazarov, Petr V., additional, Poch, Olivier, additional, Lhermitte, Benoit, additional, Chenard, Marie Pierre, additional, Burckel, Hélène, additional, Guérin, Eric, additional, Fuchs, Quentin, additional, Castel, David, additional, Noel, Georges, additional, Choulier, Laurence, additional, Dontenwill, Monique, additional, and Van Dyck, Eric, additional
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- 2021
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43. Rilpivirine in HIV-1-positive women initiating pregnancy
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Frange, Pierre, Tubiana, Roland, Sibiude, Jeanne, Canestri, Ana, Arvieux, Cédric, Brunet-Cartier, Cécile, Cotte, Laurent, Reynes, Jacques, Mandelbrot, Laurent, Warszawski, Josiane, Le Chenadec, Jérôme, Crenn-Hebert, Catherine, Floch-Tudal, Corinne, Mazy, Fabienne, Joras, Marine, Meier, Françoise, Mortier, Emmanuel, Briquet, Catherine, Ichou, Houria, Marty, Laurence, Jabbarian, Hélène, Ceccaldi, Pierre-François, Villemant, Agnès, Zarouk, Virginie, Lefort, Agnès, Ben Salah, Mariam, Hittinger, Gilles, Chamouilli, Jean-Marc, Burle, Christian, Lafeuillade, Alain, Philip, Gisèle, Lambry, Véronique, Medus, Marie, Bachelard, Germaine, Malet, Martine, Dendale-Nguyen, Joëlle, Guimard, Thomas, Guimard, Karine, Brossier, Jean-Pierre, Perre, Philippe, Esnault, Jean-Luc, Aubry, Olivier, Leautez-Nainville, Sophie, Bonnenfant, Valerie, Laine, Laeticia, Martha, Sandrine-Anne, Maurel, Elise, Francoise, Michel, Barat, Muriel, Murger, Patricia, Rouha, Mahfoud, Lévy, Marc, Lumbroso, Philippe, Checoury, Alain, Sahadatu, Osseni, Perfezou, Pascale, Blondin, Gilles, Ansart, Séverine, De Saint Martin, Luc, Le Moine, Philippe, Duthé, Jean-Charles, Daniel, Corinne, Calvez, Christian, Boutaric, Emmanuelle, Rohan, Jennifer, Bauville, Estelle, Dupre, Christelle, Lotton, Pascal, Ouamara-digue, Enora, Poinsignon, Yves, Goussef, Marie, Grelier, Anne, Mousset, Gaetane, Cudeville, Corinne, Niault, Mathilde, Belzic, Isabelle, Moreau, Philippe, Le Coz, Marie-Françoise, Vaillant, Odile Luycx, Guerin-Duplessy, Anne, Mouton-Rioux, Virginie, De Morel, Philippe, Vitrat, Virginie, Tardif, Didier, Gaillat, Jacques, Vanderbergh, Anne, Braig, Suzanne, Clavere, Gaelle, Dehlinger-Paul, Marion, Mohamed, Khaled, Echard, Marie, Camus, Michel, Mulard, Catherine, Fontelonga, Marie-Agnès, Heller-Roussin, Brigitte, Winter, Cécile, Challier, Marion, Debruyne, Elise, Marcou, Valerie, Firtion, Ghislaine, Pannier, Emmanuelle, Costa, Myriam, Launay, Odile, Salmon-Ceron, Dominique, Belkacem, Touria, Bajawi, Youcef, Aubret, Valérie Raynal, Rivaux, Danièle, Elaoun, Neila, Allal, Lahcene, Djoubou, Sandrine, Rahli, Djamila, Moine, Agnès Bourgeois, Valentin, Morgane, Damond, Florence, Huri, Virginie, Vivier, Valérie, Yahia, Fatma Ait, Garrait, Valérie, Hau, Isabelle, Touboul, Claudine, Ratsimbazafy, Lanto, Boiron, Emilie, Elharrar, Brigitte, Labaune, Jean-Marc, Rudigoz, Rene-Charles, Brochier, Corinne, Galvan, Valérie, Ogoudjobi, Stanislas, Elleau, Christophe, Runel-Belliard, Camille, Pistone, Thierry, Fleury, Hervé, Horovitz, Jacques, Sandler, Boris, Roux, Denis, Ragnaud, Jean-Marie, Chabanier, Pierre, Brun, Jean-Luc, Delveaux, Sandrine, Muanza, Blandine, Diallo, Mama Doufari, Lamaury, Isabelle, Sow, Marie-Thérèse, Samar, Ketty, Carpentier, Bénédicte, Osman, Zafer, Dienga, Etienne, Seaume, Hervé, Ducrocq, Sarah, Bailly-Salin, Philippe, Da Silva, Christelle Dusart, Fayolas, Isabelle, Abbal, Julie, Simon-Toulza, Caroline, Truillet, Véronique, Bogner, Noëlle, Chiabrando, Julie, Armand, Evelyne, Cayla, Claudine, Chacé, Anne, Matheron, Isabelle, Richier, Laurent, Miantezila, Joe, Bry, Sandrine, Couderc, Sophie, Narcy, Catherine, Routier, Corinne, Nassar, Rania, Bouldouyre, Marie-Anne, Zakaria, Ahmed, Dauphin, Hélène, Goissen, Céline, Belloy, Marie, Delassus, Jean-Luc, Favret, Véronique, Nemeth, Céline, Partisani, Marialuisa, Entz-Werlé, Natacha, Langer, Bruno, Uettwiller, Françoise, Durand, Myriam, Partizani, MariaLuisa, Cheneau, Christine, Rey, David, Ebel, Edith, Fischer, Patricia, DAVID, Eric, Vayssière, Christophe, Weil, Michèle, Schmitt, Marie Paule, Nisand, Israël, Genet, Philippe, Brault, Dominique, Allisy, Christine, Gerbe, Juliette, Masse, Virginie, Wifaq, Bouchra, Courdavault, Laurence, Gabor, Petra, Tordjeman, Nathalie, Lebrette, Marie-Gisèle, Selleret, Lise, Samama, Déborah, Bolot, Pascal, Khuong-Josses, Marie-Aude, Amel, Mahdi, Bounan, Stéphane, Nourry, Christelle, Andris, Sabine, Blanche, Stephane, Driessen, Marine, Veber, Florence, Fischer, Alain, Rouzioux, Christine, Avettand-Fenoël, Véronique, Mahlaoui, Nizar, Mourey, Marie-Christine, Granier, Michèle, Devidas, Alain, Donnadieu, Anne-Claire, May, Adrien, Chabrol, Amélie, Chevojon, Pierre, Bellahcene, Chahrazede, Sanchez, Audrey, Malbrunot, Claire, Neizelien, Joelle, Agher, Nouara, Pluchart, Claire, Rouger, Christine, Dommergues, Marc, Bonmarchand, Manuela, Shneider, Luminata, Caby, Fabienne, Calin, Ruxandra-Oana, Blanc, Christine, Lupin, Catherine, Pauchard, Michèle, Yangui, Mohamed Amine, Roca, Didier, Todorova, Darina, Laurent, Juliette, Ferry, A., Deschaud, Martine, Blum, Laurent, Chambrin, Véronique, Labrune, Philippe, Clech, Laure, Raho-Moussa, Mariem, Pauly-Ravelly, Isolde, Jault, Thierry, Bouabdallah, Soufiane, Sanchez, Lydie, Sanchez, Anita, Johnson, Ama, Louchard, Agnès, Allouche, Claude, Pathe, Jean-Paul, Lachassine, Eric, Benoist, Laurence, Jeantils, Vincent, Delannoy, Catherine, Benbara, Amélie, Carbillon, Lionel, Borgne, Anne, Moreau, Laurence, PICARD, Fabienne, Karaoui, Leïla, Elbert, Véronique Lefevre, Balaz, Valérie, Bongain, André, Monpoux, Fabrice, Deville, Anne, Galiba, Eliane, Jabbar, Ahmed, Joutel, Martine, Schmidt, Jean-Luc, Decaux, Nathalie, Cravello, Ludovic, Errichiello, Katia, Hubert, Claire, Dollfus, Catherine, Hervé, François, Tabone, Marie-Dominique, Courcoux, Mary-France, Leverger, Guy, Kayem, Gilles, Schnurgier, Aurélie, Jensen, Aurore, Vaudre, Geneviève, Pinquier, Didier, Gromez, Alexis, Pinto-Cardoso, Gaelle, Faye, Albert, Borie, Constance, Levine, Martine, Matheron, Sophie, Marouts, Erianna Bellaton, Boissinot, Christine, Caseris, Marion, Pommelet, Virginie, Morau, Geneviève, Leveille, Sandrine, Boumediene, Marie Astride, Garion, Dominique, Peretti, Delphine, Fourcade, Corinne, Houllier, Marie, Jrad, Ikram, Bourdic, Katia, Monnier, Sylvie, Chirouze, Catherine, Proust, Aurélie, Catteau, Odile, Gardiennet, Quentin, Reliquet, Véronique, Winer, Norbert, Vaucel, Edouard, Rodallec, Audrey, Garnier-André, Elisabeth, Briandet, Claire, Brouard, Jacques, Goubin, Pascale, Beucher, Gaël, Dina, Julia, Demersay, Arnaud Chalvon, Tassi, Sylvie, Lavarenne, Gaelle, Rajguru, Mandovi, Messaoudi, Fabienne, Carré, Nathalie, Rajguru, Mandavi, Bobrie-Moyrand, Claire, Foucaud, Pierre, Bernard, Louis, Maakroun, Zoha, Bourgault, Olivier, Kebaili, Kamila, Bertrand, Yves, Alixe, Véronique, Boyer, Emeline, Billiemaz, Kareen, Fanget, Cécile, Ronat, Véronique, Lesauder, Catherine, Lavastre, Marie Laure, Moulin, Alice, Turquini, Marie-France, Colombani, Dominique, Belgodere, Danièle, Fialaire, Pascale, Proust, Stéphanie, Rehaiem, Sami, Mesnard, Louis, Werner, Evelyne, Dukiel, Nathalie, Desmergers, Baya, Blanc-Ruffat, Isabelle, Maraux, Barbara, Coursol, Anne, Castaneda, Julie, Etienne, Lise, Vintejoux, Emmanuelle, Lalande, Muriel, Segondy, Michel, Guigue, Nelly, De Gennes, Christiane, Clavel, Cyril, Cazassus, François, Walter, Véronique, Mazingue, Françoise, Hammou, Yamina, Lagree, Marion, Paquiez, Odile, D’angelo, Sophie, Boquet, Laurence, Ajana, Faiza, Hatchuel, Yves, Nahri, Imad, Zebelus, Jenny, Genet, Claire, Ducroix-Roubertou, Sophie, Aubrard, Yves, Constanty, Anne, Weinbreck, Pierre, Piet, Emilie, Jacquier, Françoise, Michaud, Christophe, Safwan, Hassan, Boutet, Arnaud, Grand-Courault, Carole, Autret, Fanny, Habibi, Fakher, Azria, Elie, Abdelhadi, Mohamed, Elenga, Narcisse, Bocket, Laurence, Taillet, Françoise, Palenzuela, Gilles, Khadly, Redouane, Pierronnet, Danielle, Dos-Santos, Emmanuelle, David, Selva, Makhloufi, Djamila, Brunel-Dalmas, Florence, Carbonnel-Delalande, Elisabeth, Chiarello, Pierre, Godinot, Matthieu, Gilbert, Sylvie, Massardier, Jérôme, Gauthier-Moulinier, Hélène, Fernandes, Elisabeth, Ranaivojaona, Sata, Chevry, Coralie, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Maladies infectieuses et tropicales [CHU Tenon], CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], Centre hospitalier universitaire de Nantes (CHU Nantes), Département de maladies infectieuses, Hospices Civils de Lyon (HCL), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Hôpital Louis Mourier - AP-HP [Colombes], Chirurgie Gynécologique et Obstétrique (CGO), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Département d'infectiologie [AP-HP Hôpital Louis Mourier, Colombes], Faculté de Médecine Paris-Diderot [Paris], Université Paris Diderot - Paris 7 (UPD7), Service de Médecine Interne [AP-HP, CHU Beaujon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Beaujon [AP-HP], Service de médecine interne, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Centre Hospitalier Intercommunal Toulon-La Seyne sur Mer - Hôpital Sainte-Musse, Service de pédiatrie, Centre Hospitalier Chalon-sur-Saône William Morey, CH de Lorient, Laboratoire de Traitement de l'Information Medicale (LaTIM), Université européenne de Bretagne - European University of Brittany (UEB)-Université de Brest (UBO)-Télécom Bretagne-Institut Mines-Télécom [Paris] (IMT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Département de Médecine Interne et Pneumologie [Brest] (DMIP - Brest), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Unité d'hémato-oncologie, CHU Toulouse [Toulouse], Pôle Médico-Chirurgical de Pédiatrie et de Génétique Clinique, Néonatologie, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Service de Gynécologie et Obstétrique [Rennes] = Gynaecology [Rennes], CH Bretagne Sud, Centre d'Investigations Biomédicales - Hématologie - Oncologie - Greffes (CIB-HOG), Centre d'Investigations Biomédicales - Hématologie - Oncologie - Greffes-Hopital St Louis, Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois], Service des Maladies Infectieuses, Centre Hospitalier de la Région d'Annecy (Pringy), University of Warwick [Coventry], Physiopathologie et Pharmacotoxicologie Placentaire Humaine (U1139), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Cochin [AP-HP], Université Paris Descartes - Paris 5 (UPD5), Service de Virologie [CHU Bichat], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Hôpital de la Croix-Rousse [CHU - HCL], Réseau périnatal Aurore, Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), CHU Bordeaux [Bordeaux], pôle gynécologie-obstétrique et médecine foetale, Laboratoire Rhéologie et Procédés (LRP), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Fédération des Maladies Infectieuses [Bordeaux], CHU de Bordeaux Pellegrin [Bordeaux], Centre de compétences des microangiopathies thrombotiques, department of pathology, university hospital, parakou, CHU Pointe-à-Pitre/Abymes [Guadeloupe], Service des Maladies Infectieuses et Tropicales[Point-à-Pitre], Service de Gynécologie-Obstétrique [Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Hôpital Saint-Louis, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), CHU Strasbourg, Développement et physiopathologie de l'intestin et du pancréas, Institut National de la Santé et de la Recherche Médicale (INSERM), Service de gynécologie–obstétrique, CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], CHRU Strasbourg, Département d'échographie et de Médecine fœtale, SIHCUS-CMCO, Service de Gynécologie-Obstétrique, CHI Poissy-Saint-Germain, Centre Hospitalier Victor Dupouy, Service d'informatique médicale et biostatistiques [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Hôpital d'Argenteuil, Centre Hospitalier de Saint-Denis [Ile-de-France], Hôpital Delafontaine, Recherche Epidémiologique en Santé Périnatale et Santé des Femmes et des Enfants (UMR_S 953), Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de microbilogie & unité d'immunologie, hématologie et rhumatologie pédiatriques, Developpement Normal et Pathologique du Système Immunitaire, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Chaire Médecine expérimentale (A. Fischer), Collège de France (CdF (institution)), Laboratoire de Virologie [CHU Necker], Université Sorbonne Paris Cité (USPC), IFR Necker-Enfants Malades (IRNEM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Médecine néonatale, Centre Hospitalier Sud Francilien, Service de pneumologie [Béclère], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Antoine Béclère [Clamart], Centre Hospitalier Universitaire de Reims (CHU Reims), Service de Gynécologie-Obstétrique, Maternité, Chirurgie Gynécologique [CHU Pitié-Salpêtrière], Service de médecine interne [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Croissance cellulaire, réparation et régénération tissulaires (CRRET), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Hôpital Antoine Béclère, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Référence Maladies Héréditaires du Métabolisme Hépatique [Hôpital Antoine Béclère - APHP (CRMR), Service de rhumatologie [CHU Saint-Antoine], CHU Saint-Antoine [AP-HP], Service de gynécologie-obstétrique [Hôpital Jean Verdier], Université Paris 13 (UP13)-Hôpital Jean Verdier [AP-HP], Service de Gynécologie-Obstétrique-Reproduction, Hôpital l'Archet, Service d'Hémato-oncologie Pédiatrique [CHU Nice], Centre Hospitalier Universitaire de Nice (CHU Nice), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CHU Trousseau [APHP], Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables (ECEVE (U1123 / UMR_S_1123)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital universitaire Robert-Debré [Paris], Service des maladies infectieuses et tropicales, Service de pédiatrie générale, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Institut Pasteur du Laos, Réseau International des Instituts Pasteur (RIIP), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Service de Gynécologie Obstétrique, Service de Médecine Interne et Immunologie clinique [AP-HP Hôpital Bicêtre], Hôpital Bicêtre, Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), service de maladies infectieuses CHU J Minjoz Besancon, Service des maladies infectieuses et tropicales [CHU Nantes], Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Service de virologie [CHU Nantes], Service de Pédiatrie Enfants - Hématologie Oncologie [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Service de Pédiatrie Médicale [Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Service de Gynécologie-Obstétrique et Médecine de la Reproduction [CHU Caen], Service de Virologie [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Service de Médecine Interne et Maladies Infectieuses [Tours], Service d'hématologie : Immuno-Hématologie pédiatrique et transplantation de moelle osseuse, Hôpital Debrousse, CHU Saint-Etienne, Centre population et développement (CEPED - UMR_D 196), Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5), Médecine Néonatale et Réanimation Pédiatrique, CH René Dubos, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Hôpital Jeanne de Flandres, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service des Maladies Infectieuses et Tropicales [Hôpital Gustave Dron, Tourcoing], Centre Hospitalier Gustave Dron [Tourcoing], 'Personal Protection Against Vectors' working group (PPAV), PPAV working group, Service des Maladies infectieuses et tropicales [CHU Limoges], CHU Limoges, Equipe de Recherche Médicale Appliquée (ERMA), Université de Limoges (UNILIM)-CHU Limoges-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), CHU Annecy, Service de Pédiatrie, Centre hospitalier de Saint-Nazaire, EA 3593 Université des Antilles et de la Guyane, Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Laboratoire de virologie [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL], Service d'immunologie, Hospices Civils de Lyon (HCL)-Hôpital Edouard Herriot [CHU - HCL], Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Centre Hospitalier de Basse-Terre, Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI), Université de Rennes (UR), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Collège de France - Chaire Médecine expérimentale (A. Fischer), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), ANRS CO1/CO11, French national, Viral Hepatitis, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Service des maladies infectieuses et tropicales [CHU Tenon], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Université européenne de Bretagne - European University of Brittany (UEB)-Télécom Bretagne-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Mines-Télécom [Paris] (IMT), Hôpital des Enfants, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris-Sud - Paris 11 (UP11), CH Evry-Corbeil-CH Evry-Corbeil, CH Evry-Corbeil, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Jean Verdier [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13), Université Paris Diderot - Paris 7 (UPD7)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Laboratoire d'Electrotechnique de Lyon (LEL), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon, Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Université de Limoges (UNILIM)-CHU Limoges, Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital universitaire Robert-Debré [Paris], Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier )-Université de Montpellier (UM)
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rilpivirine ,viral suppression ,hiv ,hiv-1 ,pregnancy ,conception ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,virology - Abstract
International audience; BackgroundSafety data about rilpivirine use during pregnancy remain scarce, and rilpivirine plasma concentrations are reduced during second/third trimesters, with a potential risk of viral breakthroughs. Thus, French guidelines recommend switching to rilpivirine-free combinations (RFCs) during pregnancy.ObjectivesTo describe the characteristics of women initiating pregnancy while on rilpivirine and to compare the outcomes for virologically suppressed subjects continuing rilpivirine until delivery versus switching to an RFC.MethodsIn the ANRS-EPF French Perinatal cohort, we included women on rilpivirine at conception in 2010–18. Pregnancy outcomes were compared between patients continuing versus interrupting rilpivirine. In women with documented viral suppression (
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- 2020
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44. Involvement of MET/TWIST/APC Combination or the Potential Role of Ossification Factors in Pediatric High-Grade Osteosarcoma Oncogenesis
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Entz-Werle, Natacha, Lavaux, Thomas, Metzger, Nadia, Stoetzel, Corinne, Lasthaus, Christelle, Marec, Perrine, Kalita, Chantal, Brugieres, Laurence, Pacquement, Helene, Schmitt, Claudine, Tabone, Marie-Dominique, Gentet, Jean-Claude, Lutz, Patrick, Babin, Annie, Oudet, Pierre, Gaub, Marie Pierre, and Perrin-Schmitt, Fabienne
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- 2007
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45. SFOP OS94: A randomised trial comparing preoperative high-dose methotrexate plus doxorubicin to high-dose methotrexate plus etoposide and ifosfamide in osteosarcoma patients
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Le Deley, Marie-Cécile, Guinebretière, Jean-Marc, Gentet, Jean-Claude, Pacquement, Hélène, Pichon, Fabienne, Marec-Bérard, Perrine, Entz-Werlé, Natacha, Schmitt, Claudine, Brugières, Laurence, Vanel, Daniel, Dupoüy, Noëlle, Tabone, Marie-Dominique, and Kalifa, Chantal
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- 2007
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46. Sirolimus Pharmacokinetics Variability Points to the Relevance of Therapeutic Drug Monitoring in Pediatric Oncology
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Sabo, Amelia-Naomi, primary, Jannier, Sarah, additional, Becker, Guillaume, additional, Lessinger, Jean-Marc, additional, Entz-Werlé, Natacha, additional, and Kemmel, Véronique, additional
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- 2021
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47. Pharmacokinetics of oral vinorelbine in French children with recurrent or progressive primary low‐grade glioma.
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Hamimed, Mourad, Gattacceca, Florence, André, Nicolas, Tresch‐Bruneel, Emmanuelle, Probst, Alicia, Chastagner, Pascal, Pagnier, Anne, De Carli, Emilie, Entz‐Werlé, Natacha, Grill, Jacques, Aerts, Isabelle, Frappaz, Didier, Bertozzi‐Salamon, Anne‐Isabelle, Solas, Caroline, and Leblond, Pierre
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VINORELBINE ,GLIOMAS ,CHILD patients ,BODY surface area ,PHARMACOKINETICS ,REGRESSION analysis - Abstract
Aims: There is a crucial need for pharmacokinetic (PK) data on oral vinorelbine (VNR) in the paediatric population. The aim of this work was to assess the PK profile of orally administered VNR in children with recurrent/progressive primary low‐grade glioma (LGG). Methods: A multicentre, open‐label, single‐arm intervention phase II study was conducted. Patients, aged between 6 and 18 years, with histologically confirmed recurrent or progressive primary LGG or non‐documented typical optic pathway tumours, were included. PK parameters were estimated by non‐compartmental analysis using Phoenix WinNonlin® software (version 8.0, Certara, Inc.). The influence of demographic and biological covariates on VNR PK parameters was investigated using a multivariate linear regression analysis. Results: PK analysis included 36 patients with a median age (range) of 11 (6–17) years. Estimates of apparent oral clearance (CL/F), apparent volume of distribution (V/F), half‐life (t1/2) and their between‐subject variability (CV%) at 60 mg m−2 dose level, were 472 L h−1 (51.8%), 7002 L (57.9%) and 10 h (21.0%), respectively. Negligible accumulation of VNR between C1 and C2 was observed. CL/F and V/F were found to increase with body surface area (BSA) (P =.004). Lower area under the concentration–time curve (AUC) levels were observed among children in comparison to adults. Conclusion: Higher doses may be necessary for children with LGG. BSA showed a significant impact on VNR systemic exposure. We believe that our findings will serve as a basis for further studies to better characterize the concentration–response relationships of VNR among paediatric patients. [ABSTRACT FROM AUTHOR]
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- 2022
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48. Involvement of the TGFβ pathway in the regulation of α5β1 integrins by caveolin-1 in human glioblastoma
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Cosset, Erika C., Godet, Julien, Entz-Werlé, Natacha, Guérin, Eric, Guenot, Dominique, Froelich, Sébastien, Bonnet, Dominique, Pinel, Sophie, Plenat, François, Chastagner, Pascal, Dontenwill, Monique, and Martin, Sophie
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- 2012
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49. Prognostic relevance of clinical and molecular risk factors in children with high-risk medulloblastoma treated in the phase II trial PNET HR+5
- Author
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Dufour, Christelle, primary, Foulon, Stephanie, additional, Geoffray, Anne, additional, Masliah-Planchon, Julien, additional, Figarella-Branger, Dominique, additional, Bernier-Chastagner, Valerie, additional, Padovani, Laetitia, additional, Guerrini-Rousseau, Léa, additional, Faure-Conter, Cecile, additional, Icher, Celine, additional, Bertozzi, Anne-Isabelle, additional, Leblond, Pierre, additional, Akbaraly, Tasnime, additional, Bourdeaut, Franck, additional, André, Nicolas, additional, Chappé, Celine, additional, Schneider, Pascale, additional, De Carli, Emilie, additional, Chastagner, Pascal, additional, Berger, Claire, additional, Lejeune, Julien, additional, Soler, Christine, additional, Entz-Werlé, Natacha, additional, and Delisle, Marie-Bernadette, additional
- Published
- 2020
- Full Text
- View/download PDF
50. HGG-36. HIF-2: A NEW DRUG TARGET IN PEDIATRIC HIGH-GRADE GLIOMA WITH PROMISING PRECLINICAL RESULTS
- Author
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Fuchs, Quentin, primary, Pierrevelcin, Marina, additional, Papin, Christophe, additional, Dontenwill, Monique, additional, and Entz-Werlé, Natacha, additional
- Published
- 2020
- Full Text
- View/download PDF
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