1. Association between endoscopic pressure study integrated system (EPSIS) and high-resolution manometry
- Author
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Yusuke Fujiyoshi, Haruhiro Inoue, Yuto Shimamura, Mary Raina Angeli Fujiyoshi, Enrique Rodriguez de Santiago, Yohei Nishikawa, Akiko Toshimori, Mayo Tanabe, Kazuya Sumi, Masashi Ono, Yugo Iwaya, Haruo Ikeda, and Manabu Onimaru
- Subjects
Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background and study aims The endoscopic pressure study integrated system (EPSIS), a novel diagnostic tool for gastroesophageal reflux disease (GERD), allows evaluation of the anti-reflux barrier using endoscopy by monitoring the intragastric pressure (IGP) during insufflation. In this study, we evaluated the association between EPSIS results and lower esophageal sphincter (LES) function measured by high-resolution manometry (HRM) to elucidate whether EPSIS can evaluate the LES function. Patients and methods A retrospective, single-center study of patients with GERD symptoms who underwent endoscopy, pH-impedance monitoring, EPSIS, and HRM was conducted. The primary outcome was basal LES pressure and the secondary outcomes were end-respiratory LES pressure and integrated relaxation pressure (IRP). As EPSIS parameters, the following were measured: 1) pressure difference (mmHg), the difference between maximum and basal IGP; and 2) pressure gradient (mmHg/s), calculated by dividing pressure difference by the insufflating time. Pressure difference
- Published
- 2022
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