5 results on '"Enrica Grosso"'
Search Results
2. Image-Guided Thermal Ablation as an Alternative to Surgery for Papillary Thyroid Microcarcinoma: Preliminary Results of an Italian Experience
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Giovanni Mauri, Franco Orsi, Serena Carriero, Paolo Della Vigna, Elvio De Fiori, Dario Monzani, Gabriella Pravettoni, Enrica Grosso, Marco F. Manzoni, Mohssen Ansarin, and Gioacchino Giugliano
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papillary thyroid microcarcinoma ,radiofrequency ablation ,laser ablation ,thermal ablation ,complications ,recurrence ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
PurposeTo report the results of our preliminary experience in treating patients with papillary thyroid microcarcinoma (PTMC) with image-guided thermal ablation, in particular estimating the feasibility, safety and short-term efficacyMaterials and MethodsFrom 2018 patients with cytologically proven PTMC < 10 mm were discussed in a multidisciplinary team and evaluated for feasibility of image-guided thermal ablation. In case of technical feasibility, the three possible alternatives (i.e., image-guided thermal ablation, surgery, and active surveillance) were discussed with patients. Patients who agreed to be treated with image guided thermal ablation underwent radiofrequency (RFA) or laser ablation under local anesthesia and conscious sedation. Treatment feasibility, technical success, technique efficacy, change in thyroid function tests, side effects, minor and major complications, patients satisfaction and pain/discomfort perception during and after treatment, and disease recurrence during follow-up were recorded.ResultsA total of 13 patients were evaluated, and 11/13 (84.6%) patients (9 female, 2 male, mean age 49.3 ± 8.7 years) resulted suitable for image-guided thermal ablation. All 11 patients agreed to be treated with image-guided thermal ablation. In addition, 3/11 (27.3%) were treated with laser ablation and 8/11 (72.7%) with RFA. All procedures were completed as preoperatively planned (technical success 100%). Technique efficacy was achieved in all 11/11 (100%) cases. Ablated volume significantly reduced from 0.87 ± 0.67 ml at first follow-up to 0.17 ± 0.36 at last follow-up (p = 0.003). No change in thyroid function tests occurred. No minor or major complications occurred. All patients graded 10 the satisfaction for the treatment, and mean pain after the procedure was reported as 1.4 ± 1.7, and mean pain after the procedure as 1.2 ± 1.1 At a median follow-up of 10.2 months (range 1.5–12 months), no local recurrence or distant metastases were found.ConclusionsImage guided thermal ablations appear to be feasible and safe in the treatment of PTMC. These techniques hold the potential to offer patients a minimally invasive curative alternative to surgical resection or active surveillance. These techniques appear to be largely preferred by patients.
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- 2021
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3. Prognostic role of pre-treatment magnetic resonance imaging (MRI)-based radiomic analysis in effectively cured head and neck squamous cell carcinoma (HNSCC) patients
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Valentina D. A. Corino, Alessandra Marcantoni, Lisa Licitra, Ester Orlandi, Paolo Bossi, Laura D. Locati, Sara Valerini, Luca Bellanti, Aurora Mirabile, Iolanda De Martino, Toni Ibrahim, Stefania Vecchio, Salvatore Battaglia, Rebecca Romanò, Letizia Deantonio, Marco Ravanelli, Andrea Ferri, Tito Poli, Damiano Caruso, Fulvia Blengio, Marco Bologna, Salvatore Alfieri, Alberto Grammatica, Antonella Richetti, Achille Tarsitano, Enrica Grosso, Luca Mainardi, Giuseppina Calareso, Francesco Martucci, Alfieri S., Romano R., Bologna M., Calareso G., Corino V., Mirabile A., Ferri A., Bellanti L., Poli T., Marcantoni A., Grosso E., Tarsitano A., Battaglia S., Blengio F., De Martino I., Valerini S., Vecchio S., Richetti A., Deantonio L., Martucci F., Grammatica A., Ravanelli M., Ibrahim T., Caruso D., Locati L.D., Orlandi E., Bossi P., Mainardi L., and Licitra L.F.
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Pre treatment ,medicine.medical_specialty ,magnetic resonance imaging (MRI) ,recurrence ,Prognosi ,Disease outcome ,head and neck squamous cell carcinoma ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Retrospective Studie ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,predictive ,Retrospective Studies ,magnetic resonance imaging (mri) ,pretreatment ,prognostic ,radiomic ,medicine.diagnostic_test ,Head and Neck Neoplasm ,business.industry ,Squamous Cell Carcinoma of Head and Neck ,Magnetic resonance imaging ,Retrospective cohort study ,Hematology ,General Medicine ,Radiomic ,Magnetic Resonance Imaging ,Prognosis ,Head and Neck Neoplasms ,Neoplasm Recurrence, Local ,medicine.disease ,Head and neck squamous-cell carcinoma ,stomatognathic diseases ,Neoplasm Recurrence ,Local ,Oncology ,030220 oncology & carcinogenesis ,Radiology ,business ,Human - Abstract
Objectives: To identify and validate baseline magnetic resonance imaging (b-MRI) radiomic features (RFs) as predictors of disease outcomes in effectively cured head and neck squamous cell carcinoma (HNSCC) patients. Materials and methods: Training set (TS) and validation set (VS) were retrieved from preexisting datasets (HETeCo and BD2Decide trials, respectively). Only patients with both pre- and post-contrast enhancement T1 and T2-weighted b-MRI and at least 2years of follow-up (FUP) were selected. The combination of the best extracted RFs was used to classify low risk (LR) vs. high risk (HR) of disease recurrence. Sensitivity, specificity, and area under the curve (AUC) of the radiomic model were computed on both TS and VS. Overall survival (OS) and 5-year disease-free survival (DFS) Kaplan–Meier (KM) curves were compared for LR vs. HR. The radiomic-based risk class was used in a multivariate Cox model, including well-established clinical prognostic factors (TNM, sub-site, human papillomavirus [HPV]). Results: In total, 57 patients of TS and 137 of VS were included. Three RFs were selected for the signature. Sensitivity of recurrence risk classifier was 0.82 and 0.77, specificity 0.78 and 0.81, AUC 0.83 and 0.78 for TS and VS, respectively. VS KM curves for LR vs. HR groups significantly differed both for 5-year DFS (p
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- 2021
4. Prognostic role of pre-treatment magnetic resonance imaging (MRI) radiomic analysis in patients with squamous cell carcinoma of the head and neck (SCCHN)
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Francesco Ascoli, Sara Valerini, Letizia Deantonio, Rebecca Romanò, Toni Ibrahim, Fulvia Blengio, Laura D. Locati, Andrea Ferri, Marco Bologna, Paolo Bossi, Salvatore Alfieri, Enrica Grosso, Moela Mancinelli, Luca Mainardi, Giuseppina Calareso, Alessandra Marcantoni, Stefania Vecchio, Aurora Mirabile, Achille Tarsitano, and Lisa Licitra
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Pre treatment ,Cancer Research ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Oncology ,Radiomics ,Medicine ,In patient ,Basal cell ,Radiology ,business ,Head and neck - Abstract
6553 Background: Emerging data suggest that radiomics can be used to predict outcomes in SCCHN. At present, only few data are available for pre-treatment MRI. Methods: Study population was retrieved from an ongoing multicenter, randomized, prospective trial (NCT02262221, HETeCo) evaluating health and economic outcomes of two different follow-up (FUP) strategies (intensive vs non-intensive) in effectively cured stage III-IV (VIII TNM ed.) SCCHN. We selected only patients with both pre- and post-contrast enhancement T1 and T2-weighted baseline MRI (b-MRI) and at least 2 years (2y) of FUP. A radiomic model was developed to identify high risk (HR) and low risk (LR) of disease recurrence. Radiomic features (RF) were extracted from the primary tumor in the b-MRI. The best RF combination was selected by Least Absolute Shrinkage and Selection Operator (LASSO). Ten-fold cross-validation was used to compute sensitivity, specificity and area under the curve (AUC) of the classifier. Kaplan-Meier (KM) curves were estimated for HR and LR, for both overall survival (OS) and disease-free survival (DFS) and log rank test was performed. Three years (3y)-DFS and OS were also estimated for the two groups. The radiomic risk class was used as a new variable in a multivariate Cox model including well established prognostic factors in SCCHN (TNM stage, subsite and HPV). Results: Out of 155 enrolled HETeCO patients, 98 baseline imaging were retrieved of which 57 b-MRI. Of these, 51 met the eligibility criteria (25 in intensive and 26 in non-intensive arm). Baseline patients’ characteristics were: median age 66 yr (38-86); sex (M 42; F 9); median smoking history: 30 packs/y (1-100); 25 oral cavity (49%), 18 oropharynx (35%, 14 HPV+), 6 larynx (12%), 2 hypopharynx (4%). At a median FUP of 42 months (25-64), 45 (88%) patients are still alive. The recurrence rate was 20% (10/51, of which 2 distant). In total, 1608 RF were extracted. The sensitivity, specificity and AUC of the classifier were 90%, 76%, and 80%, respectively. The radiomic risk class was found to be an independent prognostic factor for both DFS and OS (p=0.01 and p=0.046, respectively). KM curves for DFS and OS were significantly different between HR and LR groups (p=0.002 and p=0.04, respectively). In HR vs LR, 3-y DFS and OS were: 78% [61-100%] vs 97% [90-100%], and 88% [75-100%] vs 96% [88-100%], respectively. Conclusions: Radiomics of pre-treatment MRI can predict outcomes in SCCHN. External validation of this preliminary radiomics-based model is currently ongoing.
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- 2020
5. Algorithm to predict postoperative complications in oropharyngeal and oral cavity carcinoma
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Luigi, Santoro, Marta, Tagliabue, Maria Angela, Massaro, Mohssen, Ansarin, Luca, Calabrese, Gioacchino, Giugliano, Daniela, Alterio, Maria, Cossu Rocca, Enrica, Grosso, Marek, Plànicka, Marco, Benazzo, and Fausto, Chiesa
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Adult ,Aged, 80 and over ,Male ,Adolescent ,Respiratory Tract Diseases ,Comorbidity ,Middle Aged ,Nomograms ,Oropharyngeal Neoplasms ,Young Adult ,Postoperative Complications ,Cardiovascular Diseases ,Multivariate Analysis ,Humans ,Female ,Mouth Neoplasms ,Algorithms ,Aged - Abstract
Preoperative data in patients with oral cavity/oropharyngeal cancer may predict postoperative complications that may modify therapeutic choices and improve patient care.We reviewed 320 consecutive patients with oral cavity/oropharyngeal cancer, operated on 2003 through 2006 at the European Institute of Oncology. By multivariate analysis of preoperative patient and tumor characteristics, we developed an algorithm to predict postoperative complications. We tested the algorithm on a new series of 307 patients operated on 2007 through 2010.The final algorithm used to produce a nomogram was comprised of: alcohol consumption (p = .01), site of primary (p = .03), interaction of clinical T classification to sex (p = .007), and type of neck dissection (p .0001). The algorithm had good ability to predict complications (concordance index [c-index] 0.74) in the new series.The nomogram accurately predicts presurgical risk of postoperative local/systemic complications in patients with oral cavity/oropharyngeal cancer and can be used to adapt therapy to patient characteristics, optimize ward admissions, and improve care.
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- 2013
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