7 results on '"Enoch Weikem Weyori"'
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2. Predictive signs and symptoms of bacterial meningitis isolates in Northern Ghana
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Enoch Weikem Weyori, Braimah Baba Abubakari, Bernard Nkrumah, Abass Abdul-Karim, Hilarius Asiwome Kosi Abiwu, Eugene Dogkotenge Kuugbee, Adadow Yidana, Shamsu-Deen Ziblim, Benjamin Nuertey, Benjamin Asubam Weyori, Etowi Boye Yakubu, Stebleson Azure, Valentine Cheba Koyiri, and Richard Kujo Adatsi
- Subjects
Medicine ,Science - Abstract
Abstract Cerebrospinal meningitis (CSM) is a public health burden in Ghana that causes up to 10% mortality in confirmed cases annually. About 20% of those who survive the infection suffer permanent sequelae. The study sought to understand the predictive signs and symptoms of bacterial meningitis implicated in its outcomes. Retrospective data from the Public Health Division, Ghana Health Service on bacterial meningitis from 2015 to 2019 was used for this study. A pre-tested data extraction form was used to collect patients’ information from case-based forms kept at the Disease Control Unit from 2015 to 2019. Data were transcribed from the case-based forms into a pre-designed Microsoft Excel template. The data was cleaned and imported into SPSS version 26 for analysis. Between 2015 and 2019, a total of 2446 suspected bacterial meningitis cases were included in the study. Out of these, 842 (34.4%) were confirmed. Among the confirmed cases, males constituted majority with 55.3% of the cases. Children below 14 years of age were most affected (51.4%). The pathogens commonly responsible for bacterial meningitis were Neisseria meningitidis (43.7%) and Streptococcus pneumoniae (53.0%) with their respective strains Nm W135 (36.7%), Nm X (5.1%), Spn St. 1 (26.2%), and Spn St. 12F/12A/12B/44/4 (5.3%) accounting for more than 70.0% of the confirmed cases. The presence of neck stiffness (AOR = 1.244; C.I 1.026–1.508), convulsion (AOR = 1.338; C.I 1.083–1.652), altered consciousness (AOR = 1.516; C.I 1.225–1.876), and abdominal pains (AOR = 1.404; C.I 1.011–1.949) or any of these signs and symptoms poses a higher risk for testing positive for bacterial meningitis adjusting for age. Patients presenting one and/or more of these signs and symptoms (neck stiffness, convulsion, altered consciousness, and abdominal pain) have a higher risk of testing positive for bacterial meningitis after statistically adjusting for age.
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- 2023
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3. Trends in Neisseria meningitidis serogroups amongst patients with suspected cerebrospinal meningitis in the meningitis belt of Ghana: a 5-year retrospective study
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Stebleson Azure, Abass Abdul-Karim, Braimah Baba Abubakari, John B. Eleeza, Daron Davies A. Agboyie, Enoch Weikem Weyori, and Jun Yong Choi
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Conjugate ,Meningococcal ,Non-groupable ,Polysaccharide ,Polymerase chain reaction ,Vaccination ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Serogroup A Neisseria meningitidis was the major cause of meningococcal meningitis epidemics in the African meningitis belt before 2010 when the monovalent meningococcal A conjugate vaccine (MenAfriVac) was introduced in the region. Therefore, this study aimed to establish the trends in N. meningitidis serogroups from 2016 to 2020 in Ghana’s meningitis belt. Methods Polymerase chain reaction (PCR) confirmed laboratory results of suspected cases of cerebrospinal meningitis from January, 2016 to March, 2020 were obtained from the Tamale Public Health Laboratory. The data were subjected to trend analysis using Statistical Package for the Social Sciences version 25. Differences between discrete variables were analyzed using the Cochran–Armitage trend test. Results Of the 2,426 suspected cases, 395 (16.3%) were confirmed positive for N. meningitidis using PCR. Serogroup X showed a significant upward trend (P
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- 2023
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4. Bacterial infections epidemiology and factors associated with multidrug resistance in the northern region of Ghana
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Jean-Pierre Gnimatin, Enoch Weikem Weyori, Shimea M. Agossou, and Martin Nyaaba Adokiya
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Medicine ,Science - Abstract
Abstract Bacterial infections caused by multidrug resistant organisms are a major global threat. There is still a knowledge gap on this situation in the Northern Region of Ghana. This study determined the prevalence and resistance profile of bacterial infections. It also identified factors associated with multidrug resistance in the study area. This was a retrospective cross-sectional design and it analyzed data from the samples received at the Tamale Zonal Public Health Reference Laboratory from June 2018 to May 2022. The data were analyzed using the R software version 4.2.0. Univariate and multivariable binary logistic regression analyses were used to determine the factors associated with multidrug resistance. The samples included all specimen types possible. The specimens were collected for the purpose of clinical bacteriology diagnostics. Overall a total of 1222 isolates were obtained. The three (3) main bacteria responsible for infections were: Klebsiella spp. (27%), Moraxella spp. (22%), Escherichia spp. (16%). High resistance levels were found against the tested antibiotics and about 41.60% of the bacterial strains isolated were multidrug resistant. Hospitalization was associated with multidrug resistance in univariate (COR 1.96; 95% CI 1.43–2.71; P-value
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- 2022
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5. Enormity of anaemia and its determinant factors among lactating mothers in Northern Ghana: A case of nanton district
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Adadow Yidaana, Enoch Weikem Weyori, Khadijah Wemah, Nkrumah Bernard, Braimah Baba Abubakari, Kuugbee Dogkotenge Eugene, Benjamin Nuertey, Etowi Boye Yakubu, Valentine Koyiri Cheba, and Adatsi Richard Kujo
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BackgroundAnemia remains one of the most severe and common public health conditions that predominantly affects children and women across the globe. It is defined as a condition in which the hemoglobin (Hb) concentration is less than 11.0 g/dl particularly in women. The World health organization report indicated that 20–50% of the world population was affected by iron deficiency anemia.MethodAn institutional cross-sectional study design was the method used through the data collection and management. Information was sought from four selected health centres across the nanton district with systematic sampling deployed to select respondents of interest. A sample of 420 respondents were obtained and processed for analysis. A bi-variate and multivariate analysis uncovered the associated factors and its predictiveness.ResultsThe prevalence of anaemia in totality was 56.0% (95% CI 51.3%, 60.8%). The divergence of the blood concentration levels between the means of the anaemic and non anaemic group was statistically significance (F-stat=68.233, t-stat=-35.697, pAOR = 0.054; (95% CI: 0.025, 0.119)]. Lack of post-partum iron supplementation increased the risk of having anaemia [AOR = 15.336; (95% CI: 6.112, 38.483)], and lactating mothers had higher risk [AOR = 1.927, (95% CI: 1.031, 3.602)] of developing anaemia with increasing ‘child’s age beyond three (3) months.ConclusionAnaemia remains very high in lactating mothers attributable to episodes of postpartum malaria, iron supplementation, and increasing ‘child’s age beyond 3 months. There is the need for public health interventions and measures such as extension of folic acid distribution and Intermittent Preventive Therapy (IPT) for malaria program to mothers at postnatal care and child welfare clinics across the region.
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- 2022
6. Serotypes and Serogroups implicated in Bacterial meningitis across Ghana
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Enoch Weikem Weyori, Abass Abdul-Karim, John Bertson Eleeza, Nkrumah Bernard, Braimah Baba Abubakari, Hilarius Asiwome Kosi Abiwu, Kuugbee Dogkotenge Eugene, Adadow Yidaana, Benjamin Nuertey, Adatsi Richard Kojo, Stebleson Azure, Sylvester Mensah, Etowi Boye Yakubu, Valentine Koyiri Cheba, and Alentis Aba-ifaa Dombadoh
- Abstract
BackgroundBacterial meningitis is a dangerous infection that can kill children and adults alike. An estimated 1.2 million instances of bacterial meningitis are anticipated to occur globally each year, despite the discovery of polysaccharide and conjugate vaccines in recent years [1]. The study aimed to find out which bacteria isolates are linked to meningitis and to compare the culture method to the rT-PCR method.MethodThis study examined data on bacterial meningitis from the Ghana Health Service’s Public Health Division from 2015 to 2019. Patients’ information was collected from case-based forms held at the Tamale Public Health and Reference Laboratory. The data from the case-based forms was transcribed into a pre-designed Microsoft Excel template. For analysis, the data was cleaned and loaded into Minitab version 18.ResultsThere were 2,446 CSM cases documented in all, 34.4 percent were confirmed. Males (52.7%) were more suspected than females (47.3%). Age group 15-44 were affected most (37.5%). The predominant pathogens were Neisseria meningitidis (W135) and Streptococcus pneumoniae (St.1) with NMX, St.14, St.19, and St. 12F/12A/12b as new emerging strains.Notwithstanding that, low NPV (72.6%), NLR (0.69), and sensitivity (31.8%) of culture method for detected pathogens of bacterial meningitis were found to produce a statistically significant false negatives compared to the gold standard (rT-PCR).ConclusionEmergence of new strains of bacterial meningitis and the false negative results chained out by the culture method is alarming.
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- 2022
7. Predictive signs and symptoms of Bacterial Meningitis isolates in Northern Ghana
- Author
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Enoch Weikem Weyori, Nkrumah Bernard, Abass Abdul-Karim, John Bertson Eleeza, Braimah Baba Abubakari, Hilarius Asiwome Kosi Abiwu, Kuugbee Dogkotenge Eugene, Adadow Yidaana, Shamsu-Deen Ziblim, Benjamin Nuertey, Benjamin Asubam Weyori, Etowi Boye Yakubu, Stebleson Azure, Muktar Abdul-Muizz, Valentine Koyiri Cheba, and Adatsi Richard Kojo
- Abstract
BackgroundCerebrospinal meningitis (CSM) is a public health burden in Ghana that causes up to 10% mortality of the disease annually. About 20% of those who survive cerebrospinal meningitis suffer permanent sequelae. The study sought to understand the predictive signs and symptoms of bacterial meningitis implicated in its outcomes.MethodRetrospective data from the Public Health Division, Ghana Health Service on bacterial meningitis from 2015 to 2019 used for this study. A pre-tested data extraction form was used to collect patients’ information from case-based forms kept at the Disease Control Unit from 2015 to 2019. Data were transcribed from the case-based forms into a pre-designed Microsoft Excel template. The data was cleaned and imported into SPSS version 26 for analysis.ResultsBetween 2015-2019, a total of 2,446 CSM cases were reported. Out of these, 842 were confirmed. Among the confirmed cases, males constituted 55.3%. Children below 14 years of age were most affected (51.4%). The pathogens commonly responsible for bacterial meningitis wereNeisseria meningitidisandStreptococcus pneumoniaewith their respective strains especiallyNm W135, Nm X, Spn St. 1, andSpn St. 12F/12A/12B/44/4being responsible for most of the confirmed cases. The most predictive sign and symptom for bacterial meningitis was fever (X2=5.738a;p .05; AOR=1.303). Identified signs that were associated but less likely to cause disease were abdominal pain (X2=12.038a;p .05; AOR=0.597), neck stiffness (X2=6.447a;p .05; AOR=0.788), altered consciousness (X2=15.438a;p .05; AOR=0.673), and convulsion (X2=15.084a;p .05; AOR=0.678).ConclusionThe confirmed cases of bacterial meningitis from 2015 to 2019 had fever as the main predictive symptom. It is therefore noticed that abdominal pain, neck stiffness, altered consciousness and convulsion did not associate with CSM within the study period.
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- 2022
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