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Your search keyword '"Enk, A.H."' showing total 35 results
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35 results on '"Enk, A.H."'

9. Malignant syphilis with ocular involvement and organism-depleted lesions

Author

Pleimes, M., Hartschuh, W., Kutzner, H., Enk, A.H., and Hartmann, M.

Subjects
Syphilis -- Diagnosis, Syphilis -- Care and treatment, Syphilis -- Case studies, Syphilis -- Demographic aspects, Ocular manifestations of general diseases -- Care and treatment, Ocular manifestations of general diseases -- Case studies, Penicillin G benzathine -- Dosage and administration, Penicillin G benzathine -- Case studies, Health, Health care industry
Published
2009

21. Retrospective analysis evaluating the effect of a keratolytic and physical pretreatment with salicylic acid, urea and curettage on the efficacy and safety of photodynamic therapy of actinic keratoses with methylaminolaevulinate.

Author

Gholam, P., Fink, C., Bosselmann, I., and Enk, A.H.

Subjects
PHOTODYNAMIC therapy, ACTINIC keratosis, CURETTAGE, SALICYLIC acid, UREA, THERAPEUTICS
Abstract

Background Photodynamic therapy (PDT) is a highly effective treatment option for actinic keratosis (AK). Hyperkeratosis of the AK impairs penetration of the photosensitizer and light and leads to a reduced efficacy of PDT. Therefore, it is commonly recommended to perform curettage of the AK prior to treatment. Objective This observational, monocentric, retrospective study sets out to compare the effects of curettage (CUR), chemical keratolytic pretreatment with salicylic acid 10% (SA), and urea cream 40% (UR) on the efficacy and tolerability of PDT. Method A total of 44 subjects aged 73.2 ± 7.7 years (mean ± SD) with multiple AKs (mean 11.1 per patient) in face and scalp were analysed. In 15 patients, CUR was performed prior to PDT while 15 and 14 patients underwent keratolytic pretreatment with SA and UR, respectively, 1 day prior to PDT. All patients underwent one session of methylaminolaevulinate (MAL) PDT using a 630-nm LED lamp at 37 J/cm2, pain was measured using a visual analogue scale. The response rate was calculated using the documented number of AKs prior and 4 weeks after PDT. Results Mean lesion response rates were 68.5%, 61.4% and 60.8% for CUR, SA and UR respectively. Differences were not significant. Patients with SA or UR experienced significantly more pain (SA: 6.3 ± 2.7, P = 0.02; UR: 6.1 ± 1.8, P = 0.04) than patients with curettage (4.4 ± 2.1). The cosmetic result and the patients' satisfaction 4 weeks after PDT were good to excellent in all three groups without a significant difference. However, pretreatment with SA or UR led to pronounced local reactions compared to CUR. Conclusion Keratolytic therapy with SA or UR is an effective pretreatment for PDT. However, it leads to an increase in pain during PDT and pronounced local reactions. [ABSTRACT FROM AUTHOR]

Published
2016
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30. Allergen-specific immune deviation from a T "H2 to a T "H1 response induced by dendritic cells and collagen type I

Author

Brand, U., Bellinghausen, I., Enk, A.H., Jonuleit, H., Becker, D., Knop, J., and Saloga, J.

Abstract

Background: Atopy and IgE production are associated with enhanced allergen-specific T "H2 responses. Therefore a causative treatment may result from the deviation of this T "H2-dominated immune response toward a T "H1 response. Objective: This study was carried out to analyze whether dendritic cells, the most potent antigen-presenting cells that are also known to induce antigen-specific T "H1 responses, are suitable for therapy of atopic diseases by shifting the allergen-specific T "H2 response toward a T "H1 response. Methods: Monocyte-derived dendritic cells were used to present allergens in vitro to autologous CD4^+ T cells of allergic persons. Because collagen type I activates dendritic cells and enhances the secretion of IL-12, we performed allergen presentation assays also in the presence of collagen type I. Results: After stimulation with allergen-pulsed dendritic cells the production of IFN-@c as well as that of IL-4 and IL-5 by CD4^+ T cells was enhanced. In the presence of collagen type I, however, a significant shift toward a T "H1 response with increased production of IFN-@c and a decreased production of IL-5 could be observed. When T cells were stimulated directly with anti-CD3 and anti-CD28 in the absence of antigen-presenting cells, it was demonstrated that collagen type I also exerted a direct effect on T cells, increasing their IFN-@c production. Conclusion: These data indicate that collagen type I influences dendritic cells as well as T cells in a way that a shift in cytokine production results in a T "H1 response even in already-sensitized atopic individuals. (J Allergy Clin Immunol 1999;104:1052-9.)

Published
1999
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31. The HIV tat gene is a promoter of epidermal skin tumors

Author

Vogel, J., Cepeda, M., Enk, A.H., Ngo, L., and Jay, G.

Subjects
Complications and side effects, Models, Genetic aspects, Skin diseases -- Genetic aspects -- Complications and side effects -- Models, HIV infections -- Complications and side effects -- Genetic aspects -- Models, Skin cancer -- Models -- Complications and side effects -- Genetic aspects, HIV infection -- Complications and side effects -- Genetic aspects -- Models
Abstract

According to the authors' abstract of an article published in International Journal of Oncology, 'Human immunodeficiency virus (HIV) infected patients have a very high incidence (>90%) of neoplastic and non-neoplastic [...]

Published
1995

32. Comparison of high-dose intravenous immunoglobulin ( IVIG) in a 5% and a 10% solution does not reveal a significantly different spectrum of side-effects.

Author

Rappold, L.C., Denk, K., Enk, A.H., and Hadaschik, E.N.

Subjects
INTRAVENOUS immunoglobulins, DRUG side effects
Abstract

A letter to the editor is presented regarding a study which compared the high dose of intravenous immunoglobulin (IVIG) in various solutions, not showing different spectrum of side-effects.

Published
2016
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