180 results on '"Englmaier P"'
Search Results
2. Characterization of pure and admixed brown trout (Salmo trutta) populations of high conservation value in the upper Danubian contact zone using ddRADseq genotyping
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Englmaier, Gernot K., Lecaudey, Laurène A., Schliewen, Ulrich K., Schmidt, Thomas, Schenekar, Tamara, and Weiss, Steven J.
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- 2024
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3. Accuracy of Bruch’s membrane opening minimum rim width and retinal nerve fiber layer thickness in glaucoma diagnosis depending on optic disc size
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Englmaier, Verena Anna, Storp, Jens Julian, Leclaire, Martin Dominik, Lahme, Larissa, Brücher, Viktoria Constanze, Biermann, Julia, Diener, Raphael, and Eter, Nicole
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- 2024
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4. Concerted transcriptional regulation of the morphogenesis of hypothalamic neurons by ONECUT3
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Maja Zupančič, Erik Keimpema, Evgenii O. Tretiakov, Stephanie J. Eder, Itamar Lev, Lukas Englmaier, Pradeep Bhandari, Simone A. Fietz, Wolfgang Härtig, Estelle Renaux, Andreas Villunger, Tomas Hökfelt, Manuel Zimmer, Frédéric Clotman, and Tibor Harkany
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Science - Abstract
Abstract Acquisition of specialized cellular features is controlled by the ordered expression of transcription factors (TFs) along differentiation trajectories. Here, we find a member of the Onecut TF family, ONECUT3, expressed in postmitotic neurons that leave their Ascl1 +/Onecut1/2 + proliferative domain in the vertebrate hypothalamus to instruct neuronal differentiation. We combined single-cell RNA-seq and gain-of-function experiments for gene network reconstruction to show that ONECUT3 affects the polarization and morphogenesis of both hypothalamic GABA-derived dopamine and thyrotropin-releasing hormone (TRH)+ glutamate neurons through neuron navigator-2 (NAV2). In vivo, siRNA-mediated knockdown of ONECUT3 in neonatal mice reduced NAV2 mRNA, as well as neurite complexity in Onecut3-containing neurons, while genetic deletion of Onecut3/ceh-48 in C. elegans impaired neurocircuit wiring, and sensory discrimination-based behaviors. Thus, ONECUT3, conserved across neuronal subtypes and many species, underpins the polarization and morphological plasticity of phenotypically distinct neurons that descend from a common pool of Ascl1 + progenitors in the hypothalamus.
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- 2024
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5. Concerted transcriptional regulation of the morphogenesis of hypothalamic neurons by ONECUT3
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Zupančič, Maja, Keimpema, Erik, Tretiakov, Evgenii O., Eder, Stephanie J., Lev, Itamar, Englmaier, Lukas, Bhandari, Pradeep, Fietz, Simone A., Härtig, Wolfgang, Renaux, Estelle, Villunger, Andreas, Hökfelt, Tomas, Zimmer, Manuel, Clotman, Frédéric, and Harkany, Tibor
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- 2024
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6. Short-term-outcomes of idiopathic epiretinal membranes treated with pars-plana-vitrectomy – examination of visual function and OCT-morphology
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Englmaier, Verena Anna, Storp, Jens Julian, Eter, Nicole, and Al-Nawaiseh, Sami
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- 2023
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7. Pembrolizumab (Keytruda®)-assoziierte Hypotonia bulbi
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Dierse, S., Al-Naweiseh, S., Esser, E., Englmaier, V., Eter, N., and Clemens, C. R.
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- 2023
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8. Invalid lectotypification for Synodontis victoriae Boulenger, 1906 (Siluriformes, Mochokidae) by Poll (1971), and the designation of a new lectotype
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Gernot K. Englmaier and Rupert A. Collins
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Zoology ,QL1-991 - Abstract
The lectotype and paralectotype of Synodontis victoriae Boulenger, 1906, designated by Poll (1971), were examined. Inconsistencies between data presented for the designated lectotype and the illustrated individual raise the question of whether lectotypification by Poll is valid. This case is not formally regulated by the International Code of Zoological Nomenclature, but based on Article 74.5, the lectotypification for S. victoriae should be considered invalid because it cannot unambiguously indicate a single name-bearing specimen. Thus, we designate a new lectotype for S. victoriae (BMNH 1906.5.30.191, Entebbe, standard length 188.2 mm) out of two syntypes and provide illustrations and new morphometric and meristic data for both specimens.
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- 2023
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9. Short-term-outcomes of idiopathic epiretinal membranes treated with pars-plana-vitrectomy – examination of visual function and OCT-morphology
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Verena Anna Englmaier, Jens Julian Storp, Nicole Eter, and Sami Al-Nawaiseh
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Gliosis ,Oct ,Optical coherence tomography ,Retina ,Classification ,Biomarkers ,Ophthalmology ,RE1-994 - Abstract
Abstract Background Epiretinal membranes (ERM) represent one of the most common findings in retinal examination. Structural changes of the retinal layers in patients with ERM can be visualized and classified using OCT. The purpose of this study is to evaluate structural and functional changes related to surgical treatment of ERM. Methods Monocentric retrospective analysis of 92 patients who underwent 23-gauge-pars plana vitrectomy (ppV) combined with cataract surgery for idiopathic ERM from 2015 to 2020. Visual acuity was determined directly preoperatively, at four weeks and three months postoperatively. Disease stage and tomographic biomarkers related to ERM were assessed in OCT imaging. Results 92 eyes of 92 patients were included. At the time of surgery, the mean patient age was 71 years. Visual acuity improved significantly by 2 lines postoperatively, on average from LogMar 0.4 to 0.2 (p
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- 2023
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10. Antikoagulanzienassoziierte Sterbefälle: Eine Analyse Münchner Todesbescheinigungen
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Gleich, S., Englmaier, M., Peschel, O., Graw, M., and Schäffer, B.
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- 2023
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11. Algorithmic transparency and interpretability measures improve radiologists’ performance in BI-RADS 4 classification
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Jungmann, Friederike, Ziegelmayer, Sebastian, Lohoefer, Fabian K., Metz, Stephan, Müller-Leisse, Christina, Englmaier, Maximilian, Makowski, Marcus R., Kaissis, Georgios A., and Braren, Rickmer F.
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- 2023
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12. A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology
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Julian Petersen, Lukas Englmaier, Artem V. Artemov, Irina Poverennaya, Ruba Mahmoud, Thibault Bouderlique, Marketa Tesarova, Ruslan Deviatiiarov, Anett Szilvásy-Szabó, Evgeny E. Akkuratov, David Pajuelo Reguera, Hugo Zeberg, Marketa Kaucka, Maria Eleni Kastriti, Jan Krivanek, Tomasz Radaszkiewicz, Kristína Gömöryová, Sarah Knauth, David Potesil, Zbynek Zdrahal, Ranjani Sri Ganji, Anna Grabowski, Miriam E. Buhl, Tomas Zikmund, Michaela Kavkova, Håkan Axelson, David Lindgren, Rafael Kramann, Christoph Kuppe, Ferenc Erdélyi, Zoltán Máté, Gábor Szabó, Till Koehne, Tibor Harkany, Kaj Fried, Jozef Kaiser, Peter Boor, Csaba Fekete, Jan Rozman, Petr Kasparek, Jan Prochazka, Radislav Sedlacek, Vitezslav Bryja, Oleg Gusev, and Igor Adameyko
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Science - Abstract
Abstract In this study we use comparative genomics to uncover a gene with uncharacterized function (1700011H14Rik/C14orf105/CCDC198), which we hereby name FAME (Factor Associated with Metabolism and Energy). We observe that FAME shows an unusually high evolutionary divergence in birds and mammals. Through the comparison of single nucleotide polymorphisms, we identify gene flow of FAME from Neandertals into modern humans. We conduct knockout experiments on animals and observe altered body weight and decreased energy expenditure in Fame knockout animals, corresponding to genome-wide association studies linking FAME with higher body mass index in humans. Gene expression and subcellular localization analyses reveal that FAME is a membrane-bound protein enriched in the kidneys. Although the gene knockout results in structurally normal kidneys, we detect higher albumin in urine and lowered ferritin in the blood. Through experimental validation, we confirm interactions between FAME and ferritin and show co-localization in vesicular and plasma membranes.
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- 2023
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13. The Preserflo MicroShunt Affects Microvascular Flow Density in Optical Coherence Tomography Angiography
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Jens Julian Storp, Hannah Schatten, Friederike Elisabeth Vietmeier, Ralph-Laurent Merté, Larissa Lahme, Julian Alexander Zimmermann, Verena Anna Englmaier, Nicole Eter, and Viktoria Constanze Brücher
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surgery ,device ,intraocular pressure ,IOP ,vessel density ,MIGS ,Biology (General) ,QH301-705.5 - Abstract
Intraocular pressure (IOP) lowering surgery has been shown to alter microvascular density in glaucoma patients. The aim of this study is to report changes in retinal flow density (FD) over the course of treatment with the Preserflo MicroShunt, using optical coherence tomography angiography (OCTA). 34 eyes from 34 patients who underwent Preserflo MicroShunt implantation were prospectively enrolled in this study. OCTA imaging was conducted at the superficial (SCP), deep (DCP) and radial peripapillary plexus (RPC) levels. The progression of FD and IOP was assessed at different time points from baseline to six months postoperatively for the entire patient population, as well as disease severity subgroups. The Preserflo MicroShunt achieved a significant reduction in IOP over the course of six months (median: 8 mmHg; p < 0.01). FD values of the SCP and DCP did not show significant fluctuations, even after adjusting for disease severity. FD of the RPC decreased significantly over the course of six months postoperatively from 42.31 at baseline to 39.59 at six months postoperatively (p < 0.01). The decrease in peripapillary FD was strongest in patients with advanced glaucoma (median: −3.58). These observations hint towards dysfunctional autoregulatory mechanisms in capillaries surrounding the optic nerve head in advanced glaucoma. In comparison, the microvascular structure of the macula appeared more resilient to changes in IOP.
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- 2023
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14. General patterns of sexual dimorphism in graylings (Thymallus), with a comparison to other salmonid species
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Englmaier, Gernot K., Antonov, Alexander, and Weiss, Steven J.
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- 2022
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15. Author Correction: A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology
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Julian Petersen, Lukas Englmaier, Artem V. Artemov, Irina Poverennaya, Ruba Mahmoud, Thibault Bouderlique, Marketa Tesarova, Ruslan Deviatiiarov, Anett Szilvásy-Szabó, Evgeny E. Akkuratov, David Pajuelo Reguera, Hugo Zeberg, Marketa Kaucka, Maria Eleni Kastriti, Jan Krivanek, Tomasz Radaszkiewicz, Kristína Gömöryová, Sarah Knauth, David Potesil, Zbynek Zdrahal, Ranjani Sri Ganji, Anna Grabowski, Miriam E. Buhl, Tomas Zikmund, Michaela Kavkova, Håkan Axelson, David Lindgren, Rafael Kramann, Christoph Kuppe, Ferenc Erdélyi, Zoltán Máté, Gábor Szabó, Till Koehne, Tibor Harkany, Kaj Fried, Jozef Kaiser, Peter Boor, Csaba Fekete, Jan Rozman, Petr Kasparek, Jan Prochazka, Radislav Sedlacek, Vitezslav Bryja, Oleg Gusev, and Igor Adameyko
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Science - Published
- 2023
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16. Genetic diversity of Nile tilapia (Oreochromis niloticus) populations in Ethiopia: insights from nuclear DNA microsatellites and implications for conservation
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Genanaw Tesfaye, Manuel Curto, Paul Meulenbroek, Gernot K. Englmaier, Papius Dias Tibihika, Esayas Alemayehu, Abebe Getahun, and Harald Meimberg
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Ethiopian Rift Valley ,Cichlid ,Genotyping ,Admixture ,Freshwater biodiversity ,Stocking ,Ecology ,QH540-549.5 ,Evolution ,QH359-425 - Abstract
Abstract Background Nile tilapia, Oreochromis niloticus (Linnaeus, 1758) is among the economically most important freshwater fish species in East Africa, and a major source of protein for local consumption. Human induced translocations of non-native stocks for aquaculture and fisheries have been found as a potential threat to the genetic diversity and integrity of local populations. In the present study, we investigate the genetic structure of O. niloticus from 16 waterbodies across Ethiopia using 37 microsatellite loci with SSR-GBAS techniques. Results The samples are structured into three main clusters shaped either by biogeographic factors or stocking activities. High F ST values (Global F ST = 0.438) between populations indicate a high level of genetic differentiation and may suggest long term isolation even within the same drainage systems. Natural populations of the Omo-Turkana system and the lakes in the Southern Main Ethiopian Rift showed the highest genetic variability while low variability was found in stocked populations of lakes Hora, Hashenge and Hayq. Conclusions The results presented herein, may provide an essential basis for the management and conservation of the unique genetic resources in northern East Africa, and advance our understanding of biodiversity, phylogeny, evolution and development towards phylogenetically more accurate taxonomic classifications.
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- 2021
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17. Global systematic diversity, range distributions, conservation and taxonomic assessments of graylings (Teleostei: Salmonidae; Thymallus spp.)
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Weiss, Steven J., Gonçalves, Duarte V., Secci-Petretto, Giulia, Englmaier, Gernot K., Gomes-Dos-Santos, André, Denys, Gael P. J., Persat, Henri, Antonov, Alexander, Hahn, Christoph, Taylor, Eric B., and Froufe, Elsa
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- 2021
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18. New data on Garra makiensis (Cyprinidae, Labeoinae) from the Awash River (Ethiopia) with remarks on its relationships to congeners on the Arabian Peninsula
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Gernot K. Englmaier, Nuria Viñuela Rodríguez, Herwig Waidbacher, Anja Palandačić, Genanaw Tesfaye, Wolfgang Gessl, and Paul Meulenbroek
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Zoology ,QL1-991 - Abstract
On the African continent, the genus Garra consists of several species often insufficiently separated from each other by diagnostic characters. Herein, a detailed morphological redescription of Garra makiensis from the Awash River drainage is presented, together with additional data on the type specimens of G. makiensis and G. rothschildi. Mitochondrial CO1 sequence data are also provided, including the historic paralectotype of G. makiensis, with a comparison to Garra species from Africa and the Middle East. Based on these sequences, G. makiensis clusters outside the group of African congeners and is a sister lineage to species from the south-east of the Arabian Peninsula. Although morphologically variable, G. makiensis is characterised by having a single unbranched pectoral-fin ray, a short distance between vent and anal-fin origin (7.3–19.7 % of pelvic – anal distance), chest and belly covered with scales, and a prominent axillary scale at base of pelvic fin (18.8–35.5 % of pelvic-fin length).
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- 2020
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19. A new species of Enteromius (Actinopterygii, Cyprinidae, Smiliogastrinae) from the Awash River, Ethiopia, and the re-establishment of E. akakianus
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Gernot K. Englmaier, Genanaw Tesfaye, and Nina G. Bogutskaya
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Zoology ,QL1-991 - Abstract
In the present study, populations of small-sized smiliogastrin barbs with a thickened and serrated last simple dorsal-fin ray distributed in the Main Ethiopian Rift were analysed. An integrated approach combining genetic markers and a variety of morphological methods based on a wide set of characters, including osteology and sensory canals, proved to be very productive for taxonomy in this group of fishes. The results showed that Ethiopian Enteromius species with a serrated dorsal-fin ray are distant from the true E. paludinosus (with E. longicauda as a synonym) and the so-called E. paludinosus complex involves several supposedly valid species with two distinct species occurring in the Main Ethiopian Rift area. A new species, Enteromius yardiensis sp. nov., is described from the Afar Depression in the north-eastern part of the Northern Main Ethiopian Rift. Enteromius akakianus is resurrected as a valid species including populations from the Central Main Ethiopian Rift (basins of lakes Langano, Ziway, and Awasa). No genetic data were available for E. akakianus from its type locality. Enteromius yardiensis sp. nov. is clearly distant from E. akakianus from the Central Main Ethiopian Rift by CO1 and cytb barcodes: pairwise distances between the new species and the Ethiopian congeners were 5.4 % to 11.0 %. Morphologically, the new species most clearly differs from all examined Ethiopian congeners by three specialisations which are unique in the group: the absence of the anterior barbel, the absence of the medial branch of the supraorbital sensory canal, and few, 1–3, commonly two, scale rows between the lateral line and the anus.
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- 2020
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20. Genetic diversity of Nile tilapia (Oreochromis niloticus) populations in Ethiopia: insights from nuclear DNA microsatellites and implications for conservation
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Tesfaye, Genanaw, Curto, Manuel, Meulenbroek, Paul, Englmaier, Gernot K., Tibihika, Papius Dias, Alemayehu, Esayas, Getahun, Abebe, and Meimberg, Harald
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- 2021
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21. Longitudinal river zonation in the tropics: examples of fish and caddisflies from the endorheic Awash River, Ethiopia
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Englmaier, Gernot K., Hayes, Daniel S., Meulenbroek, Paul, Terefe, Yonas, Lakew, Aschalew, Tesfaye, Genanaw, Waidbacher, Herwig, Malicky, Hans, Wubie, Alemayehu, Leitner, Patrick, and Graf, Wolfram
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- 2020
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22. Comparative genetic analysis of grayling (Thymallus spp. Salmonidae) across the paleohydrologically dynamic river drainages of the Altai-Sayan mountain region
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Weiss, Steven, Grimm, Jacqueline, Gonçalves, Duarte V., Secci-Petretto, Giulia, Englmaier, Gernot K., Baimukanov, Mirgaliy, and Froufe, Elsa
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- 2020
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23. Managerial Payoff and Gift-Exchange in the Field
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Englmaier, Florian and Leider, Stephen
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- 2020
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24. The complexity of bony malalignment in patellofemoral disorders: femoral and tibial torsion, trochlear dysplasia, TT–TG distance, and frontal mechanical axis correlate with each other
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Imhoff, Florian B., Funke, Victor, Muench, Lukas N., Sauter, Andreas, Englmaier, Maximilian, Woertler, Klaus, Imhoff, Andreas B., and Feucht, Matthias J.
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- 2020
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25. The Milky Way Spiral Arm Pattern
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Englmaier, Peter, Pohl, Martin, and Bissantz, Nicolai
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Astrophysics - Abstract
A complete map of the 3D distribution of molecular (CO) gas was constructed using a realistic dynamical model of the gas flow in the barred potential of the Milky Way. The map shows two prominent spiral arms starting at the bar ends connecting smoothly to the 4-armed spiral pattern observed in the atomic hydrogen gas in the outer Galaxy. Unlike previous attempts, our new map uncovers the gas distribution in the bar region of the Galaxy and the far side of the disk. For the first time, we can follow spiral arms in gas as they pass behind the galactic centre., Comment: 6 pages, 4 figures. To appear in "Tumbling, Twisting, and Winding Galaxies: Pattern Speeds along the Hubble Sequence", E. M. Corsini and V. P. Debattista (eds.), Memorie della Societa Astronomica Italiana
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- 2008
26. Evaluation of a shortened cardiac MRI protocol for left ventricular examinations: diagnostic performance of T1-mapping and myocardial function analysis
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Jonathan Nadjiri, Anna-Lena Zaschka, Alexandra S. Straeter, Andreas Sauter, Maximilian Englmaier, Florian Weis, Karl-Ludwig Laugwitz, Ernst J. Rummeny, Daniela Pfeiffer, and Michael Rasper
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Cardiac MRI ,Economic ,Shortened protocol ,T1mapping ,CMR ,Medical technology ,R855-855.5 - Abstract
Abstract Background In this study we sought to retrospectively evaluate whether a very brief cardiac magnetic resonance imaging (CMR) protocol sufficiently distinguishes patients with relevant myocardial changes with need for further examination from healthy subjects. Methods Patients with clinical indication for CMR (n = 160) were included in the study. Patients were categorized into two groups depending on presence of left ventricular (LV) dysfunction. ROC-analysis was done for results of T1-, T2- mapping and extracellular volume evaluation in patients without LV dysfunction. Binary endpoint was correctly depicted pathology of the conventional qualitative CMR techniques and report. Results In the patient cohort without LV dysfunction (49%), AUC for T1 mapping was 82% (p
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- 2019
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27. 3D Distribution of Molecular Gas in the Barred Milky Way
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Pohl, Martin, Englmaier, Peter, and Bissantz, Nicolai
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Astrophysics - Abstract
We present a new model of the three-dimensional distribution of molecular gas in the Milky Way Galaxy, based on CO line data. Our analysis is based on a gas-flow simulation of the inner Galaxy using smoothed-particle hydrodynamics (SPH) using a realistic barred gravitional potential derived from the observed COBE/DIRBE near-IR light distribution. The gas model prescribes the gas orbits much better than a simple circular rotation model and is highly constrained by observations, but it cannot predict local details. In this study, we provide a 3D map of the observed molecular gas distribution using the velocity field from the SPH model. A comparison with studies of the Galactic Center region suggests that the main structures are reproduced but somewhat stretched along the line-of-sight, probably on account of limited resolution of the underlying SPH simulation. The gas model will be publicly available and may prove useful in a number of applications, among them the analysis of diffuse gamma-ray emission as measured with GLAST., Comment: ApJ in press
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- 2007
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28. Magnetic fields in barred galaxies. V. Modelling NGC 1365
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Moss, D., Snodin, A. P., Englmaier, P., Shukurov, A., Beck, R., and Sokoloff, D. D.
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Astrophysics - Abstract
We present a model of the global magnetic field in the barred galaxy NGC 1365 based jointly on the large-scale velocity field of interstellar gas fitted to HI and CO observations of this galaxy and on mean-field dynamo theory. The aim of the paper is to present a detailed quantitative comparison of a galactic dynamo model with independent radio observations. We consider several gas dynamical and nonlinear dynamo models that include plausible variations of parameters that are poorly known. Models of cosmic ray distribution in the galaxy are introduced to produce synthetic radio polarization maps allowing direct comparison with those observed at 3.5cm and 6.2cm. We show that the dynamo model is robust in that the most important magnetic features are controlled by the relatively well established properties of the density distribution and gas velocity field. The optimal agreement between the synthetic polarization maps and observations is obtained when a uniform cosmic ray distribution is adopted. We find some indirect evidence for enhanced turbulence in the regions of strong velocity shear and within 1-2kpc of the galactic centre. We confirm that magnetic stresses can drive an inflow of gas into the inner 1kpc of the galaxy at a rate of a few solar masses per year. The dynamo models are successful to some extent in modelling the large scale regular magnetic field in this galaxy. Our results demonstrate that dynamo models and synthetic polarization maps can provide information about both the gas dynamical models and conditions in the interstellar medium. We demonstrate that the dynamical effects of magnetic fields cannot be everywhere ignored in galaxy modelling., Comment: 14 pages, 25 figures, Accepted for publication in A&A
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- 2007
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29. Milky Way Gas Dynamics
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Englmaier, P. and Gerhard, O.
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Astrophysics - Abstract
The Milky Way is made up of a central bar, a disk with embedded spiral arms, and a dark matter halo. Observational and theoretical constraints for the characteristic parameters of these components will be presented, with emphasis on the constraints from the dynamics of the Milky Way gas. In particular, the fraction of dark matter inside the solar radius, the location of the main resonances, and the evidence for multiple pattern speeds will be discussed., Comment: 19 pages, 6 figures, invited review talk, AAS-DDA 36th annual meeting, April 2005, Santa Barbara, to appear in: Celestial Mechanics and Dynamical Astronomy
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- 2006
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30. Molecular Gas in NUclei of GAlaxies (NUGA) III. The warped LINER NGC3718
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Krips, M., Eckart, A., Neri, R., Pott, J. U., Leon, S., Combes, F., Garcia-Burillo, S., Hunt, L. K., Baker, A. J., Tacconi, L. J., Englmaier, P., Schinnerer, E., and Boone, F.
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Astrophysics - Abstract
We present the first interferometric observations of CO(1-0) and CO(2-1) line emission from the warped LINER NGC3718, obtained with the IRAM PdBI. This L1.9 galaxy has a prominent dust lane and on kpc scales, a strongly warped atomic and molecular gas disk. The molecular gas is closely associated with the dust lane across the nucleus and its kinematic center is consistent with the mm continuum AGN. A comparison of our interferometric mosaic data, which fully cover the ~9kpc warped disk, with a previously obtained IRAM 30m single dish CO(1-0) map shows that the molecular gas distribution in the disk is heavily resolved by the PdBI map. After applying a short-spacing correction with the IRAM 30m data, we find in total six main source components within the dust lane: one associated with the nucleus, four symmetrically positioned on either side at galactocentric distances of about 1.3kpc and 4.0kpc from the center, and a sixth on the western side at ~3kpc with only a very weak eastern counterpart. In the framework of a kinematic model using tilted rings, we interpret the five symmetric source components as locations of strong orbital crowding. We further find indications that the warp appears not only on kpc scales, but continues down to 250pc. Besides the sixth feature on the western side, the lower flux of the eastern components compared to the western ones indicates an intrinsic large scale asymmetry in NGC3718 that cannot be explained by the warp. Indications for a small scale asymmetry are also seen in the central 600pc. These asymmetries might be evidence for a tidal interaction with a companion galaxy (large scales) and gas accretion onto the nucleus (small scales). Our study of NGC3718 is part of the NUGA project that aims at investigating the different processes of gas accretion onto AGN., Comment: 16 pages, 17 figures, accepted by A&A, high resolution version of the paper available at
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- 2005
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31. Dynamical Decoupling of Nested Bars: Self-Gravitating Gaseous Nuclear Bars
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Englmaier, Peter and Shlosman, Isaac
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Astrophysics - Abstract
A substantial fraction of barred galaxies host additional nuclear bars which tumble with pattern speeds exceeding those of the large-scale (primary) stellar bars. We have investigated the mechanism of formation and dynamical decoupling in such nested bars which include gaseous (secondary) nuclear bars within the full size galactic disks, hosting a double inner Lindblad resonance. Becoming increasingly massive and self-gravitating, the nuclear bars lose internal (circulation) angular momentum to the primary bars and increase their strength. Developing chaos within these bars triggers a rapid gas collapse -- bar contraction. During this time period, the secondary bar pattern speed Omega_s~a^{-1}, where "a" stands for the bar size. As a result, Omega_s increases dramatically until a new equilibrium is reached (if at all), while the gas specific angular momentum decreases -- demonstrating the dynamical decoupling of nested bars. Viscosity, and therefore the gas presence, appears to be a necessary condition for the prograde decoupling of nested bars. This process maintains an inflow rate of ~1 M_o/yr over ~10^8 yrs across the central 200 pc and has important implications for fueling the nuclear starbursts and AGN., Comment: 7 pages, 4 postscript figures. (The associated MPEG movie can be requested from the authors directly.) Submitted to Astrophysical Journal Letters
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- 2004
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32. Feeding AGN: new results from the NUGA survey
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Garcia-Burillo, S., Combes, F., Schinnerer, E., Boone, F., Hunt, L. K., Eckart, A., Tacconi, L. J., Leon, S., Baker, A. J., Englmaier, P., and Neri, R.
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Astrophysics - Abstract
The NUGA project is a high-resolution (0.5''-1'') CO survey of low luminosity AGN including the full sequence of activity types (Seyferts, LINERs and transition objects). NUGA aims to systematically study the different mechanisms for gas fueling of AGNs in the Local Universe. In this paper we discuss the latest results of this recently completed survey, which now includes newly acquired subarcsec resolution observations for all targets of the sample. The large variety of circumnuclear disk morphologies found in NUGA galaxies (m=1, m=2 and stochastic instabilities) is a challenging result that urges the refinement of current dynamical models. In this paper we report on new results obtained in 4 study cases for NUGA: NGC4826, NGC7217, NGC4579 and NGC6951, Comment: 4 pages, 2 figures. Contributed talk to appear in "The Interplay among Black Holes, Stars and ISM in Galactic Nuclei," Proc. IAU 222 (Gramado, Brazil), eds. Th. Storchi Bergmann, L.C. Ho, H.R. Schmitt
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- 2004
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33. NUclei of GAlaxies (NUGA): the IRAM Survey of Low Luminosity AGN
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Garcia-Burillo, S., Combes, F., Eckart, A., Tacconi, L. J., Hunt, L. K., Leon, S., Baker, A. J., Englmaier, P., Boone, F., Schinnerer, E., and Neri, R.
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Astrophysics - Abstract
The NUGA project is the first high-resolution (0.5''-1'') CO survey of low luminosity AGN including the full sequence of activity types (Seyfert 1--2 and LINERs). NUGA aims to study systematically the different mechanisms for gas fueling of the AGN. In order to reach the critical spatial scales for AGN feeding (<100 pc), we are undertaking high-resolution observations, made at the Plateau de Bure Interferometer, to achieve a sharp view of the distribution and kinematics of molecular gas. In this talk we discuss the latest results of this survey which now includes newly acquired subarcsec resolution observations for 5 targets of our sample. The large variety of circumnuclear disk morphologies found in NUGA galaxies (m=1, m=2 and m=0-type gravitational instabilities) is a challenging result that urges the refinement of current dynamical models., Comment: Contributed Talk to the 4th Cologne-Bonn-Zermatt-Symposium: The Dense Interstellar Medium in Galaxies, September 2003. Conference Proceedings
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- 2003
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34. Molecular Gas in NUclei of GAlaxies (NUGA): II. The Ringed LINER NGC7217
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Combes, F., Garcia-Burillo, S., Boone, F., Hunt, L. K., Baker, A. J., Eckart, A., Englmaier, P., Leon, S., Neri, R., Schinnerer, E., and Tacconi, L. J.
- Subjects
Astrophysics - Abstract
We present CO(1-0) and CO(2-1) maps of the LINER galaxy NGC7217, obtained with the IRAM interferometer, at 2.4"x1.9" and 1.2"x0.8" resolution respectively. The nuclear ring (at r=12"=0.8kpc) dominates the CO maps, and has a remarkable sharp surface density gradient at its inner edge. The latter is the site of the stellar/Halpha ring, while the CO emission ring extends farther or is broader (500-600pc). This means that the star formation has been more intense toward the inner edge of the CO ring, in a thin layer, just at the location of the high gas density gradient. In the CO(2-1) map, a central concentration inside 3" coincides with a spiral dust lane, clearly seen in the HST V-I color image. N-body simulations including gas dissipation and star formation are performed to better understand the nature of the nuclear ring observed. In the best model, the gas content was higher in the recent past (having been consumed via star formation), and the oval/spiral formed were more self-gravitating (abridged)., Comment: 16 pages, 23 figures, accepted in Astronomy and Astrophysics
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- 2003
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35. Large-scale Gas Dynamics in the Milky Way
- Author
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Englmaier, P., Gerhard, O. E., and Bissantz, N.
- Subjects
Astrophysics - Abstract
We present new gas flow models for the Milky Way inside the solar circle. Using a mass model derived from the COBE/DIRBE maps and clump giant star counts, and using a parametric model for the spiral arm pattern in the disk, we calculate the gas flow and compare with 12CO observations. We find that models with 4 spiral arms fit the observations better then 2-armed models. We also find that models with separate pattern speeds for the bar and spiral arms can explain the gas flow in the bar corotation region better than single-pattern speed models., Comment: invited talk, 7 pages, LaTeX, full resolution version available at http://www.astro.unibas.ch/~ppe/papers/mw-boston.ps.gz, to appear in Milky Way Surveys: The Structure and Evolution of Our Galaxy, eds. D. Clemens, T. Brainerd, R. Shah
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- 2003
36. Molecular Gas in NUclei of GAlaxies (NUGA) I.The counter-rotating LINER NGC4826
- Author
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Garcia-Burillo, S., Combes, F., Hunt, L. K., Boone, F., Baker, A. J., Tacconi, L. J., Eckart, A., Neri, R., Leon, S., Schinnerer, E., and Englmaier, P.
- Subjects
Astrophysics - Abstract
We present new high-resolution observations of the nucleus of the counter-rotating LINER NGC4826, made in the J=1-0 and J=2-1 lines of 12CO with the IRAM Plateau de Bure mm-interferometer(PdBI).The CO maps, which achieve 0.8''(16pc) resolution in the 2-1 line, fully resolve an inner molecular gas disk which is truncated at an outer radius of 700pc. The total molecular gas mass is distributed in a lopsided nuclear disk of 40pc radius and two one-arm spirals, which develop at different radii in the disk. The distribution and kinematics of molecular gas in the inner 1kpc of NGC4826 show the prevalence of different types of m=1 perturbations in the gas. Although dominated by rotation, the gas kinematics are perturbed by streaming motions related to the m=1 instabilities. The non-circular motions associated with the inner m=1 perturbations agree qualitatively with the pattern expected for a trailing wave developed outside corotation ('fast' wave). In contrast, the streaming motions in the outer m=1 spiral are better explained by a 'slow' wave. A paradoxical consequence is that the inner m=1 perturbations would not favour AGN feeding. An independent confirmation that the AGN is not being generously fueled at present is found in the low values of the gravitational torques exerted by the stellar potential for R<530pc. The distribution of star formation in the disk of NGC4826 is also strongly asymmetrical. Massive star formation is still vigorous, fed by the significant molecular gas reservoir at R<700pc. There is supporting evidence for a recent large mass inflow episode in NGC4826. These observations have been made in the context of the NUclei of GAlaxies (NUGA) project, aimed at the study of the different mechanisms for gas fueling of AGN., Comment: A&A, 2003, Paper accepted (04/06/03). For a full-resolution version of this paper see http://www.oan.es/preprints
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- 2003
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37. Gas Dynamics in the Milky Way: Second Pattern Speed and Large-Scale Morphology
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Bissantz, Nicolai, Englmaier, Peter, and Gerhard, Ortwin
- Subjects
Astrophysics - Abstract
We present new gas flow models for the Milky Way inside the solar circle. To this end we use SPH simulations in gravitational potentials determined from the NIR luminosity distribution (including spiral arms) which are based on the COBE/DIRBE maps. Gas flows in models which include massive spiral arms clearly match the observed 12CO lvplot better than if the potential does not include spiral structure. Besides single pattern speed models we investigate models with separate pattern speeds for the bar and spiral arms. The most important difference is that in the latter case the gas spiral arms go through the bar corotation region, keeping the gas aligned with the arms there. In the (l,v) plot this results in characteristic regions which appear to be nearly void of gas.In single pattern speed models these regions are filled with gas because the spiral arms dissolve in the bar corotation region. Comparing with the 12CO data we find evidence for separate pattern speeds in the Milky Way.From a series of models the preferred range for the bar pattern speed is Om_p=60\pm5 /Gyr, corresponding to corotation at 3.4\pm0.3kpc. The spiral pattern speed is less well constrained, but our preferred value is Om_sp\approx 20 /Gyr. A further series of gas models is computed for different bar angles, using separately determined luminosity models and gravitational potentials in each case. We find acceptable gas models for 20<=\phibar<=25. The model with (\phibar=20, Om_p=60 /Gyr, Om_sp=20 /Gyr) gives an excellent fit to the spiral arm ridges in the observed (l,v) plot., Comment: Paper accepted for publication in MNRAS. The paper contains many figures. These are not included in the version available here to save download time. A full version can be downloaded from http://latour.stochastik.math.uni-goettingen.de/~downloads/sphpaper.ps.gz
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- 2002
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38. NUGA: the IRAM survey of AGN spiral hosts
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Garcia-Burillo, S., Combes, F., Eckart, A., Tacconi, L. J., Hunt, L. K., Leon, S., Baker, A. J., Englmaier, P. P., Boone, F., Schinnerer, E., and Neri, R.
- Subjects
Astrophysics - Abstract
The NUclei of GAlaxies (NUGA) project is a combined effort to carry out a high-resolution (<1'') interferometer CO survey of a sample of 12 nearby AGN spiral hosts, using the IRAM array. We map the distribution and dynamics of molecular gas in the inner 1 kpc of the nuclei with resolutions of 10-50 pc, and study the mechanisms for gas fueling of the different low-luminosity AGN. First results show evidence for the occurrence of strong m=1 gas instabilities in Seyferts. NUGA maps allow us to address the origin/nature of m=1 modes and their link with m=2 modes and acoustic instabilities, present in other targets., Comment: 1 gzipped tar file containing 1 Latex file + 3 eps figures. Proceedings of ''Active Galactic Nuclei: from Central Engine to Host Galaxy'', meeting held in Meudon, France, July 23-27, 2002, Eds.: S. Collin, F. Combes and I. Shlosman. To be published in ASP Conference Series
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- 2002
39. Molecular gas in the 3-ringed Seyfert/Liner galaxy NGC 7217
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Combes, F., Garcia-Burillo, S., Boone, F., Hunt, L. K., Leon, S., Eckart, A., Baker, A. J., Tacconi, L. J., Englmaier, P., Schinnerer, E., and Neri, R.
- Subjects
Astrophysics - Abstract
We present CO(1-0) and CO(2-1) maps of the Seyfert galaxy NGC 7217, obtained with the IRAM interferometer, at 3" and 1.5" resolution respectively. The nuclear ring (at r=12"=0.8kpc) is predominant in the CO maps, with a remarkable surface density gradient between the depleted region inside the ring and the inner border of the ring. The CO nuclear ring is significantly broader (500-600pc) than the dust lane ring. The CO(2-1)/CO(1-0) ratio is around 1, typical of optically thick gas with high density. The overall morphology of the ring is quite circular, with no evidence of non-circular velocities. In the CO(2-1) map, a central concentration might be associated with the circumnuclear ring of ionised gas detected inside r=3" and interpreted as a polar ring by Sil'chenko and Afanasiev (2000). Our interpretation is more in terms of a bar/spiral structure, in the same plane as the global galaxy but affected by non-circular motions, which results in a characteristic S-shape of the isovels. This nuclear bar/spiral structure, clearly seen in a V-I HST colour image, is essentially gaseous and might be explained with acoustic waves., Comment: 2 pages, 1 figure, Proceedings SF2A-2002, Paris, ed. F. Combes and D. Barret, EDP-Sciences
- Published
- 2002
40. Gas Dynamics in NGC 5248: Fueling a Circumnuclear Starburst Ring of Super Star Clusters
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Jogee, Shardha, Shlosman, Isaac, Laine, Seppo, Englmaier, Peter, Knapen, Johan H., Scoville, Nick Z., and Wilson, Christine D.
- Subjects
Astrophysics - Abstract
Through observations and modeling, we demonstrate how the recently discovered large-scale bar in NGC 5248 generates spiral structure which extends from 10 kpc down to 100 pc, fuels star formation on progressively smaller scales, and drives disk evolution. Deep inside the bar, two massive molecular spirals cover nearly 180 degrees in azimuth, show streaming motions of 20--40 km/s and feed a starburst ring of super star clusters at 375 pc. They also connect to two narrow K-band spirals which delineate the UV-bright star clusters in the ring. The data suggest that the K-band spirals are young, and the starburst has been triggered by a bar-driven spiral density wave (SDW). The latter may even have propagated closer to the center where a second Halpha ring and a dust spiral are found. The molecular and HST data support a scenario where stellar winds and supernovae efficiently clear out gas from dense star-forming regions on timescales less than a few Myrs. We have investigated the properties of massive CO spirals within the framework of bar-driven SDWs, incorporating the effect of gas self-gravity. We find good agreement between the model predictions and the observed morphology, kinematics, and pitch angle of the spirals. This combination of observations and modeling provides the best evidence to date for a strong dynamical coupling between the nuclear region and the surrounding disk. It also confirms that a low central mass concentration, which may be common in late-type galaxies, is particularly favorable to the propagation of a bar-driven gaseous SDW deep into the central region of the galaxy, whereas a large central mass concentration favors other processes, such as the formation and decoupling of nuclear bars., Comment: Accepted by ApJ. Figures 6, 7, 8, and 13 are color jpeg files. For a version of the paper with high resolution figures see ftp://ftp.astro.caltech.edu/users/sj/astroph/n5248-p2-highres.ps.gz
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- 2002
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41. Discovery and Implications of a New Large-Scale Stellar Bar in NGC 5248
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Jogee, Shardha, Knapen, Johan H., Laine, Seppo, Shlosman, Isaac, Scoville, Nick Z., and Englmaier, Peter
- Subjects
Astrophysics - Abstract
For decades, the grand-design SAB spiral galaxy NGC 5248 has been postulated to host a short bar of semi-major axis 22" (1.6 kpc). From dynamical and morphological arguments, we argue, however, that its spiral structure is being driven by a large-scale bar whose corotation radius lies at around 115" (8.6 kpc).Our estimate is based partially on a deep R-band image which reveals that the feature previously thought to be an inclined disk is in fact an extended stellar bar. The bar is embedded within a fainter outer disk visible out to a radius of 230" (17.2 kpc). The bar has a deprojected ellipticity of 0.44 and a semi-major axis of 95" (7.1 kpc). The classical grand-design spirals of NGC 5248, prominent in B, R, and K light, lie on the leading edge of the large-scale stellar bar and are accompanied by concave dust lanes out to at least 70". The offset between the dust and young stars is consistent with our understanding of gas flows in barred galaxies, where shocks along the leading edges of a moderately strong bar compress the gas to form massive young stars. While in many strongly barred galaxies, optical spiral arms are prominent outside the bar but not within it, NGC 5248 illustrates how intense star formation along a moderately strong bar can lead to conspicuous open spiral arms within the bar itself. NGC 5248 also provides a clear example of how a large-scale stellar bar embedded within a faint outer optical disk can be misidentified as an inclined disk when imaging studies lack the sensitivity to detect the actual outer disk. We discuss the implications for the estimated bar fraction at higher redshifts., Comment: Accepted by ApJL. 12 pages, 3 figures, preprint style. For a version of the paper with high resolution figures see ftp://ftp.astro.caltech.edu/users/sj/astroph/n5248-p1-highres.ps.gz
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- 2002
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42. Double Bars in Disk Galaxies: Dynamical Decoupling of Non-Self-Gravitating Gaseous Bars
- Author
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Heller, Clayton, Shlosman, Isaac, and Englmaier, Peter
- Subjects
Astrophysics - Abstract
We find that nuclear rings in barred galaxies can be subject to a new type of non-self-gravitational dynamical instability. The instability leads to the formation of gaseous molecular bars with pattern speeds which are substantially slower than speeds of the primary stellar bars. This spectacular decoupling of nuclear bars from the underlying gravitational potential is triggered but is not driven by the gas viscosity. We find that low-viscosity systems can spend a substantial period of time in a fully decoupled state, with the nuclear bar slowly tumbling in the gravitational field of the primary bar. Higher viscosity systems form nuclear bars which librate about the primary bar. The shape of a nuclear bar, i.e., its eccentricity, correlates strongly with the angle between the bars. We also find that such decoupling, partial or full, most probably will be associated with bursts of star formation and with gas inflow across the inner (Lindblad) resonance zone towards smaller radii., Comment: 10 pages, Latex plus 8 figures, ApJ double column macros, mpeg simulations available from the on-line edition of the Astrophysical Journal, or from authors. to be published in Astrophysical Journal, Vol. 551, April 20, 2001
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- 2001
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43. Circumnuclear kinematics in NGC 5248: the origin of nuclear spiral arms
- Author
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Laine, S., Knapen, J. H., Perez-Ramirez, D., Englmaier, P., and Matthias, M.
- Subjects
Astrophysics - Abstract
We present for the first time a two-dimensional velocity field of the central region of the grand-design spiral galaxy NGC 5248, at 0.9 arcsec spatial resolution. The H-alpha velocity field is dominated by circular rotation. While no systematic streaming motions are seen in the area of the nuclear grand-design spiral or the circumnuclear ring, the amplitude of residual velocities, after subtracting a model circular velocity field, reaches 20 km/s in projection. The rotation curve levels out at around 140 km/s, after a well-resolved and rather shallow rise. We have generated an analytical model for the nuclear spiral and fitted it to our observations to obtain estimates of the pattern speed of the spiral and the sound speed in the central region of NGC 5248. Our results are consistent with a low pattern speed, suggesting that the nuclear spiral rotates with the same rate as the main spiral structure in NGC 5248, and thus that the spiral structure is coupled from scales of a few hundred parsecs to several kiloparsecs. We have also compared the observed structure and kinematics between the nuclear regions of NGC 5248 and M100. Several similarities and differences are discussed, including the location of the peak emission regions on major and minor axes, and the spiral arm streaming motions. We find no kinematic evidence for a presence of a nuclear bar in NGC 5248., Comment: Accepted for publication in MNRAS
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- 2001
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44. Gas Flow and Star Formation in the `Antennae' Galaxies NGC 4038/9
- Author
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Englmaier, P., Rigopoulou, D., and Mengel, S.
- Subjects
Astrophysics - Abstract
The prominent interacting galaxy pair NGC 4038/9 contains many active star-forming regions and is continuously forming new star clusters. We present a self-consistent n-body model for this system which includes an SPH gas component. The model qualitatively explains the apparent concentration of gas in the so-called overlap region between the two nuclei as a bridge of gas connecting the two galaxies. Projected on the sky, the bridge appears as a dense spot of gas. We discuss some implications for the evolution of Ultra-luminous infrared galaxies., Comment: To appear in proceedings of Gas and Galaxy Evolution, (VLA 20th Anniversary Conference), ASP Conf. Series, ed. J. Hibbard, M. Rupen, & J. van Gorkom. 2 pages, no figures, uses newpasp.sty
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- 2000
45. Gas Streams and Spiral Structure in the Milky Way
- Author
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Englmaier, Peter
- Subjects
Astrophysics - Abstract
The observed gas dynamics in the Milky Way can only be explained by a bar in the galactic center. Such a bar is directly visible in the near-IR maps of the bulge, where it causes a distinctive asymmetric light distribution pattern. Another large-scale structure is the grand-design 4-arm spiral pattern, most clearly observed in the spatial distribution of molecular gas and HII-regions. In order to model the observed gas flow structure, we constructed a model for the stellar mass distribution. For the inner 5 $\kpc$ we used the 3D deprojected near-IR light distribution, as observed by the COBE/DIRBE experiment, and added an analytical disk model outside the box as well as a halo model. With this frozen mass distribution, we computed the stationary gas flow for various deprojection parameters and pattern speeds. For all reasonable parameter choices, we obtain a 4-armed spiral pattern, which can be matched to the observed spiral arms. In the bar region, our model can explain the non-circular motion visible in the terminal velocity curve as well as part of the forbidden velocities. Inside the corotation, we also find 4 spiral arms, the nearest arm corresponds to the 3-kpc-arm, although only qualitatively. The missing southern 3-kpc-arm at the far end of the galaxy is explained by running parallel to another arm. Close to the center, we find gas on circular orbits forming a disk. Such a disk has been observed in emission of the CS molecule, however only part of the disk appears to be occupied by dense enough gas to be traced by CS. Further we compare our model to the distribution of OH/IR stars in the inner galaxy., Comment: 17 pages, 6 figures, to appear in Reviews in Modern Astronomy Vol. 13
- Published
- 2000
46. VEGF-Trap Modulates Retinal Inflammation in the Murine Oxygen-Induced Retinopathy (OIR) Model
- Author
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Jesús Eduardo Rojo Arias, Vanessa Elisabeth Englmaier, and József Jászai
- Subjects
Aflibercept ,VEGF-Trap ,microglia ,retina ,inflammation ,oxygen-induced retinopathy ,Biology (General) ,QH301-705.5 - Abstract
Anti-Vascular Endothelial Growth Factor (VEGF) agents are the first-line treatment for retinal neovascular diseases, which represent the most prevalent causes of acquired vision loss world-wide. VEGF-Trap (Aflibercept, AFL), a recombinant decoy receptor recognizing ligands of both VEGFR-1 and -2, was recently reported to be highly efficient in improving visual acuity and preserving retinal anatomy in individuals affected by diabetic macular edema. However, the precise molecular and cell biological mechanisms underlying the beneficial effects of this novel tool have yet to be elucidated. Using the mouse oxygen-induced retinopathy (OIR) model as a surrogate of retinopathies with sterile post-ischemic inflammation, such as late proliferative diabetic retinopathy (PDR), retinopathy of prematurity (ROP), and diabetic macular edema (DME), we provide evidence that AFL modulates inflammation in response to hypoxia by regulating the morphology of microglial cells, a parameter commonly used as a proxy for changes in their activation state. We show that AFL administration during the hypoxic period of OIR leads to an increased number of ramified Iba1+ microglial cells/macrophages while subsequently limiting the accumulation of these cells in particular retinal layers. Our results suggest that, beyond its well-documented beneficial effects on microvascular regeneration, AFL might exert important modulatory effects on post-ischemic retinal inflammation.
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- 2022
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47. Density Waves Inside Inner Lindblad Resonance: Nuclear Spirals in Disk Galaxies
- Author
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Englmaier, Peter and Shlosman, Isaac
- Subjects
Astrophysics - Abstract
We analyze formation of grand-design two-arm spiral structure in the nuclear regions of disk galaxies. Such morphology has been recently detected in a number of objects using high-resolution near-infrared observations. Motivated by the observed (1) continuity between the nuclear and kpc-scale spiral structures, and by (2) low arm-interarm contrast, we apply the density wave theory to explain the basic properties of the spiral nuclear morphology. In particular, we address the mechanism for the formation, maintenance and the detailed shape of nuclear spirals. We find, that the latter depends mostly on the shape of the underlying gravitational potential and the sound speed in the gas. Detection of nuclear spiral arms provides diagnostics of mass distribution within the central kpc of disk galaxies. Our results are supported by 2D numerical simulations of gas response to the background gravitational potential of a barred stellar disk. We investigate the parameter space allowed for the formation of nuclear spirals using a new method for constructing a gravitational potential in a barred galaxy, where positions of resonances are prescribed., Comment: 18 pages, 9 figures, higher resolution available at http://www.pa.uky.edu/~ppe/papers/nucsp.ps.gz
- Published
- 1999
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48. The Face-on View of the Milky Way: Gas Dynamics in the COBE NIR Bulge and Disk
- Author
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Englmaier, Peter and Gerhard, Ortwin E.
- Subjects
Astrophysics - Abstract
We report simulations of the gas flow in the gravitational potential of the COBE NIR bulge and disk. These models lead to four--armed spiral structure between corotation of the bar and the Sun, in agreement with the observed spiral arm tangents. The 3-kpc-arm is identified with one of the arms emanating from the ends of the bar., Comment: Latex, 4 pages, 2 figures. To appear in the proceedings of the `Galaxy Dynamics' conference held at Rutgers Univ., August 8-12, 1998
- Published
- 1998
49. Gas Dynamics and Large-Scale Morphology of the Milky Way Galaxy
- Author
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Englmaier, Peter and Gerhard, Ortwin
- Subjects
Astrophysics - Abstract
We present a new model for the gas dynamics in the galactic disk inside the Sun's orbit. Quasi-equilibrium flow solutions are determined in the gravitational potential of the deprojected COBE NIR bar and disk, complemented by a central cusp and, in some models, an outer halo. These models generically lead to four-armed spiral structure between corotation of the bar and the solar circle; their large-scale morphology is not sensitive to the precise value of the bar's pattern speed, to the orientation of the bar with respect to the observer, and to whether or not the spiral arms carry mass. Our best model provides a coherent interpretation of many observed gas dynamical features. Its four-armed spiral structure outside corotation reproduces quantitatively the directions to the five main spiral arm tangents at |l|<=60deg observed in a variety of tracers. The 3-kpc-arm is identified with one of the model arms emanating from the ends of the bar, extending into the corotation region. The model features an inner gas disk with a cusped orbit shock transition to an x_2 orbit disk of radius R~150pc. The bar's corotation radius is fairly well--constrained at R_c=3.5 +/- 0.5 kpc. The best value for the orientation angle of the bar is probably 20-25deg, but the uncertainty is large since no detailed quantitative fit to all features in the observed lv-diagrams is yet possible. The Galactic terminal velocity curve from HI and CO observations out to l=+/-45deg (=5 kpc) is approximately described by a maximal disk model with constant mass-to-light ratio for the NIR bulge and disk., Comment: 24 pages, 16 figures, Latex, to appear in MNRAS. Available with full resolution figures at http://www.astro.unibas.ch/galaxies/papers.html
- Published
- 1998
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50. At a Crossroads to Cancer: How p53-Induced Cell Fate Decisions Secure Genome Integrity
- Author
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Dario Rizzotto, Lukas Englmaier, and Andreas Villunger
- Subjects
p53 ,cell cycle ,DREAM-complex ,cell death ,PIDDosome ,CIN ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
P53 is known as the most critical tumor suppressor and is often referred to as the guardian of our genome. More than 40 years after its discovery, we are still struggling to understand all molecular details on how this transcription factor prevents oncogenesis or how to leverage current knowledge about its function to improve cancer treatment. Multiple cues, including DNA-damage or mitotic errors, can lead to the stabilization and nuclear translocation of p53, initiating the expression of multiple target genes. These transcriptional programs may be cell-type- and stimulus-specific, as is their outcome that ultimately imposes a barrier to cellular transformation. Cell cycle arrest and cell death are two well-studied consequences of p53 activation, but, while being considered critical, they do not fully explain the consequences of p53 loss-of-function phenotypes in cancer. Here, we discuss how mitotic errors alert the p53 network and give an overview of multiple ways that p53 can trigger cell death. We argue that a comparative analysis of different types of p53 responses, elicited by different triggers in a time-resolved manner in well-defined model systems, is critical to understand the cell-type-specific cell fate induced by p53 upon its activation in order to resolve the remaining mystery of its tumor-suppressive function.
- Published
- 2021
- Full Text
- View/download PDF
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