1. Spatiotemporal structure of cell fate decisions in murine neural crest
- Author
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Maria Eleni Kastriti, David A. Guertin, G. Giacomo Consalez, Julian Petersen, Ruslan A. Soldatov, Xiaoyan Qian, Yunshi Yang, Tatiana Chontorotzea, Wen Yu Hsiao, Michael L. Piacentino, Markus M. Hilscher, Jean-François Brunet, Matthias Farlik, Viacheslav Dyachuk, Marketa Kaucka, Kaj Fried, Martin Häring, Chika Yokota, Mats Nilsson, Peter V. Kharchenko, Lukas Englmaier, Christoph Bock, Laura Croci, Igor Adameyko, Marianne E. Bronner, Franck Boismoreau, Patrik Ernfors, Natalia Akkuratova, Soldatov, R, Kaucka, M, Kastriti, Me, Petersen, J, Chontorotzea, T, Englmaier, L, Akkuratova, N, Yang, Y, Häring, M, Dyachuk, V, Bock, C, Farlik, M, Piacentino, Ml, Boismoreau, F, Hilscher, Mm, Yokota, C, Qian, X, Nilsson, M, Bronner, M, Croci, L, Hsiao, Wy, Guertin, D, Brunet, Jf, Consalez, Gg, Ernfors, P, Fried, K, Kharchenko, Pv, and Adameyko, I
- Subjects
0301 basic medicine ,Cell type ,Neural Tube ,Ectomesenchyme ,Neurogenesis ,Nerve Tissue Proteins ,Biology ,Cell fate determination ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Cranial neural crest ,Single-cell analysis ,Neural Stem Cells ,medicine ,Basic Helix-Loop-Helix Transcription Factors ,Animals ,Cell Lineage ,Neurons ,Multidisciplinary ,Twist-Related Protein 1 ,Neural tube ,Neural crest ,Gene Expression Regulation, Developmental ,Nuclear Proteins ,Mesenchymal Stem Cells ,Embryonic stem cell ,Mice, Mutant Strains ,030104 developmental biology ,medicine.anatomical_structure ,Neural Crest ,Single-Cell Analysis ,Neuroscience ,Neuroglia ,030217 neurology & neurosurgery - Abstract
Binary decisions refine fate decisions Neural crest cells develop into tissues ranging from craniofacial bones to peripheral neurons. Combining single-cell RNA sequencing with spatial transcriptomics, Soldatov et al. analyzed how neural crest cells in mouse embryos decide among the various fates available to them (see the Perspective by Mayor). These multipotent cells become biased toward a given fate early on and step through a progression of binary decisions as their fate is refined. Competing fate programs coexist until increased synchronization favors one and repression disfavors the other. Science , this issue p. eaas9536 ; see also p. 937
- Published
- 2019