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9. Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children

Author

Madrid-Gambin, Francisco, Föcking, Melanie, Sabherwal, Sophie, Heurich, Meike, English, Jane A., O’Gorman, Aoife, Suvitaival, Tommi, Ahonen, Linda, Cannon, Mary, Lewis, Glyn, Mattila, Ismo, Scaife, Caitriona, Madden, Sean, Hyötyläinen, Tuulia, Orešič, Matej, Zammit, Stanley, Cagney, Gerard, Cotter, David R., and Brennan, Lorraine

Published
2019
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10. Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis

Author

Grabrucker, Stefanie, primary, Marizzoni, Moira, additional, Silajdžić, Edina, additional, Lopizzo, Nicola, additional, Mombelli, Elisa, additional, Nicolas, Sarah, additional, Dohm-Hansen, Sebastian, additional, Scassellati, Catia, additional, Moretti, Davide Vito, additional, Rosa, Melissa, additional, Hoffmann, Karina, additional, Cryan, John F, additional, O’Leary, Olivia F, additional, English, Jane A, additional, Lavelle, Aonghus, additional, O’Neill, Cora, additional, Thuret, Sandrine, additional, Cattaneo, Annamaria, additional, and Nolan, Yvonne M, additional

Published
2023
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19. Faecal microbiota transplantation from Alzheimer’s participants induces impairments in neurogenesis and cognitive behaviours in rats

Author

Grabrucker, Stefanie, primary, Marizzoni, Moira, additional, Silajdžić, Edina, additional, Lopizzo, Nicola, additional, Mombelli, Elisa, additional, Nicolas, Sarah, additional, Dohm-Hansen, Sebastian, additional, Scassellati, Catia, additional, Moretti, Davide Vito, additional, Rosa, Melissa, additional, Hoffmann, Karina, additional, English, Jane A, additional, Lavelle, Aonghus, additional, O’Neill, Cora, additional, Thuret, Sandrine, additional, Cattaneo, Annamaria, additional, and Nolan, Yvonne M, additional

Published
2022
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20. Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case–Control Study of the ALSPAC Longitudinal Birth Cohort

Author

English, Jane A, Lopez, Lorna M, O’Gorman, Aoife, Föcking, Melanie, Hryniewiecka, Magdalena, Scaife, Caitriona, Sabherwal, Sophie, Wynne, Kieran, Dicker, Patrick, Rutten, Bart P F, Lewis, Glynn, Zammit, Stanley, Cannon, Mary, Cagney, Gerard, and Cotter, David R

Published
2018
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21. Student teamwork in professional programmes in higher education: a comparative study of Spain and South Africa

Author

Nudelman, Gabrielle, Kalil, Claudia, Navarro-Astor, Elena, English, Jane, Nudelman, Gabrielle, Kalil, Claudia, Navarro-Astor, Elena, and English, Jane

Abstract

Teamwork is a fundamental employability skill and, as such, is fostered in professional programmes. This study presents a comparative analysis of higher education students' perceptions, development, and experiences of teamwork at two universities: one in South Africa and the other in Spain. These study sites provided a fruitful opportunity for comparison, given their contextual similarities. Through a survey of 395 3rd and 4th-year students of professional degrees, the authors explored how these students developed the teamwork skills required within their curricula. The findings showed that respondents from both institutions perceive teamwork similarly, but there are significant differences in how these skills are developed. While most South African respondents had participated in courses focused on team functioning, the Spanish had learnt to function in teams during project work. Furthermore, the South African sample was more aware of the impact of socio-cultural factors on team functioning than the Spanish one. The former reported feeling marginalised due to their race, gender and language to a greater extent than the Spanish. The paper outlines the potential benefits of successful teamwork, such as improving social cohesion. The results could be useful to policymakers and lecturers designing context-specific interventions to develop students' teamwork skills.

Published
2022

23. Philosophy

Author

English, Jane

Published
1978

29. Effect of L-Ergothioneine on the metabolic plasma profile of the RUPP rat model of preeclampsia

Author

Morillon, Aude Claire, Williamson, Rachel D., Baker, Philip N., Kell, Douglas B., Kenny, Louise C., English, Jane A., McCarthy, Fergus P., McCarthy, Cathal, Morillon, Aude Claire, Williamson, Rachel D., Baker, Philip N., Kell, Douglas B., Kenny, Louise C., English, Jane A., McCarthy, Fergus P., and McCarthy, Cathal

Abstract

Introduction Pre-eclampsia is a major cause of maternal and fetal mortality and morbidity worldwide. Its pathophysiology remains unclear, but mitochondrial dysfunction and oxidative stress have been implicated. L-Ergothioneine is a naturally occurring, water-soluble betaine, that has demonstrated antioxidant properties. Using the reduced uterine perfusion pressure (RUPP) rat model of pre-eclampsia, this study aimed to define the plasma metabolic profile following treatment with L-Ergothioneine. Methods The effect of L-Ergothioneine (ET) treatment was explored using in vivo treatment in rats: Sham control (SC, n = 5), RUPP control (RC, n = 5), Sham +ET (ST, n = 5), RUPP +ET (RT, n = 5). Differential expression of plasma metabolites were obtained using untargeted liquid chromatography coupled to mass spectrometry. Statistical analysis was performed on normalised data comparing RC to SC, RT to RC, and RT to ST. Metabolites significantly altered (FDR < 0.05) were identified through database search. Results We report significantly lower levels of L-palmitoylcarnitine in RC compared to SC, a fatty acyl substrate involved in beta-oxidation in the mitochondria. We report that a metabolite that has been associated with oxidative stress (Glutamylcysteine) was detected at significantly higher levels in RT vs RC and RT vs ST. Five metabolites associated with inflammation were significantly lower in RT vs RC and three metabolites in RT vs ST, demonstrating the anti-inflammatory effects of ET in the RUPP rat model of pre-eclampsia. Conclusions L-Ergothioneine may help preserve mitochondrial function by increasing antioxidant levels, and reducing inflammatory responses associated with pre-eclampsia. This study shows the potential of L-Ergothioneine as a treatment for pre-eclampsia.

Published
2020

35. Instructing facilitators to support the communication of people who use augmentative communication systems

Author

Light, Janice, Dattilo, John, English, Jane, Gutierrez, Lisa, and Hartz, Jane

Subjects
Aphasic persons, Disabled persons, Health, Languages and linguistics
Abstract

A single-subject multiple-baseline design, replicated across three dyads, was used to examine the efficacy of instructing facilitators (i.e., significant others) to promote communication with people who use augmentative and alternative communication (AAC) systems.Facilitators were instructed in four 1-hour sessions to decrease their conversational control and provide more opportunities for the participants using AAC systems to communicate. Following instruction, facilitators decreased their rates of turn-taking and initiations and increased the proportion of turns that were responsive. Participants using AAC systems increased the frequency of their initiations. Following intervention, turn-taking and initiation patterns in the dyads were more reciprocal. Generalization occurred to the natural environment. Results suggest that facilitator instruction is an effective and efficient means of promoting greater participation in daily interactions by people who use AAC systems.

Published
1992

37. Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case–Control Study of the ALSPAC Longitudinal Birth Cohort

Author

English, Jane A., Lopez, Lorna, OGorman, Aoife, Focking, Melanie, Hryniewicka, Magdalena, Scaife, Caitriona, Sabherwal, Sophie, Wynne, Kieran, Dicker, Patrick, Rutten, Bart P.F., Lewis, Glynn, Zammit, Stanley, Cannon, Mary, Cagney, Gerard, Cotter, David R., English, Jane A., Lopez, Lorna, OGorman, Aoife, Focking, Melanie, Hryniewicka, Magdalena, Scaife, Caitriona, Sabherwal, Sophie, Wynne, Kieran, Dicker, Patrick, Rutten, Bart P.F., Lewis, Glynn, Zammit, Stanley, Cannon, Mary, Cagney, Gerard, and Cotter, David R.

Abstract

The identification of early biological changes associated with the psychotic disorder (PD) is important as it may provide clues to the underlying pathophysiological mechanisms. We undertook the first proteomic profiling of blood plasma samples of children who later develop a PD. Participants were recruited from the UK Avon Longitudinal Study of Parents and Children (ALSPAC) cohort who also participated in psychiatric assessment interviews at age 18. Protein expression levels at age 11 were compared between individuals who developed PD at age 18 (n = 37) with population-based agematched controls (n = 38). Sixty out of 181 plasma proteins profiled were found to be differentially expressed (P < .05) in children with an outcome of the PD. Thirty-four of these proteins were found to be differentially expressed following correction for multiple comparisons. Pathway analysis implicated the complement and coagulation cascade. A second, targeted proteomic approach was used to verify these findings in age 11 plasma from subjects who reported psychotic experiences at age 18 (n = 40) in comparison to age-matched controls (n = 66). Our findings indicate that the complement and coagulation system is dysregulated in the blood during childhood before the development of the PD.

Published
2018

38. Professional Communication: Deliver Effective Written, Spoken and Visual Messages

Author

English, Jane and English, Jane

Subjects
Written communication, Oral communication, Business communication, English language--Business English
Abstract

Professional Communication: Deliver effective written, spoken and visual messages Fourth Edition is aimed at all professionals and students in business, industry and higher education institutions. It offers sound advice, clear guidelines and numerous practical examples, and this latest edition includes managing digital communication platforms, creating templates, being interviewed for a job, raising funding, and conducting and managing Internet research. Designed and written as an easy, instant reference and practical aid for all levels of readers, it has proved its success as a textbook in academia, and as a resource in industry.

Published
2017

39. Anxiety, depression, and stress in response to the coronavirus disease-19 pandemic.

Author

Pérez-Cano, Héctor J., Moreno-Murguía, Madeleine B., Morales-López, Oscar, Crow-Buchanan, Olliever, English, Jane A., Lozano-Alcázar, Jaime, and Somilleda-Ventura, Selma A.

Subjects
ANXIETY, COVID-19 pandemic, MENTAL depression, PSYCHOLOGICAL stress, PSYCHOLOGICAL factors
Abstract

Copyright of Cirugía y Cirujanos is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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45. Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells

Author

Topol, Aaron, primary, Zhu, Shijia, additional, Hartley, Brigham J., additional, English, Jane, additional, Hauberg, Mads E., additional, Tran, Ngoc, additional, Rittenhouse, Chelsea Ann, additional, Simone, Anthony, additional, Ruderfer, Douglas M., additional, Johnson, Jessica, additional, Readhead, Ben, additional, Hadas, Yoav, additional, Gochman, Peter A., additional, Wang, Ying-Chih, additional, Shah, Hardik, additional, Cagney, Gerard, additional, Rapoport, Judith, additional, Gage, Fred H., additional, Dudley, Joel T., additional, Sklar, Pamela, additional, Mattheisen, Manuel, additional, Cotter, David, additional, Fang, Gang, additional, and Brennand, Kristen J., additional

Published
2017
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46. Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case–Control Study of the ALSPAC Longitudinal Birth Cohort

Author

English, Jane A, primary, Lopez, Lorna M, additional, O’Gorman, Aoife, additional, Föcking, Melanie, additional, Hryniewiecka, Magdalena, additional, Scaife, Caitriona, additional, Sabherwal, Sophie, additional, Wynne, Kieran, additional, Dicker, Patrick, additional, Rutten, Bart P F, additional, Lewis, Glynn, additional, Zammit, Stanley, additional, Cannon, Mary, additional, Cagney, Gerard, additional, and Cotter, David R, additional

Published
2017
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47. 126. Altered Complement and Coagulation Cascade in Age 11 Children Precedes to the Onset of Psychotic Disorder

Author

Cotter, David, primary, English, Jane, additional, Lopez, Lorna, additional, O’Gorman, Aoife, additional, Hryniewiecka, Magdalena, additional, Scaife, Catriona, additional, Sabherwal, Sophie, additional, Wynne, Kieran, additional, Dicker, Patrick, additional, Zammit, Stanley, additional, Cannon, Mary, additional, and Cagney, Gerard, additional

Published
2017
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50. Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells

Author

Topol, Aaron, primary, Zhu, Shijia, additional, Hartley, Brigham J., additional, English, Jane, additional, Hauberg, Mads E., additional, Tran, Ngoc, additional, Rittenhouse, Chelsea Ann, additional, Simone, Anthony, additional, Ruderfer, Douglas M., additional, Johnson, Jessica, additional, Readhead, Ben, additional, Hadas, Yoav, additional, Gochman, Peter A., additional, Wang, Ying-Chih, additional, Shah, Hardik, additional, Cagney, Gerard, additional, Rapoport, Judith, additional, Gage, Fred H., additional, Dudley, Joel T., additional, Sklar, Pamela, additional, Mattheisen, Manuel, additional, Cotter, David, additional, Fang, Gang, additional, and Brennand, Kristen J., additional

Published
2016
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