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26 results on '"Engelman, Zoar J."'

11. Surgical ablation of the right greater splanchnic nerve for the treatment of heart failure with preserved ejection fraction: first‐in‐human clinical trial

Author

Málek, Filip, primary, Gajewski, Piotr, additional, Zymliński, Robert, additional, Janczak, Dariusz, additional, Chabowski, Mariusz, additional, Fudim, Marat, additional, Martinca, Tomas, additional, Neužil, Petr, additional, Biegus, Jan, additional, Mates, Martin, additional, Krüger, Andreas, additional, Skalský, Ivo, additional, Bapna, Anisha, additional, Engelman, Zoar J., additional, and Ponikowski, Piotr P., additional

Published
2021
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12. Splanchnic nerve modulation in heart failure: mechanistic overview, initial clinical experience, and safety considerations

Author

Fudim, Marat, primary, Ponikowski, Piotr P., additional, Burkhoff, Daniel, additional, Dunlap, Mark E., additional, Sobotka, Paul A., additional, Molinger, Jeroen, additional, Patel, Manesh R., additional, Felker, G. Michael, additional, Hernandez, Adrian F., additional, Litwin, Sheldon E., additional, Borlaug, Barry A., additional, Bapna, Anisha, additional, Sievert, Horst, additional, Reddy, Vivek Y., additional, Engelman, Zoar J., additional, and Shah, Sanjiv J., additional

Published
2021
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15. Endovascular Ablation of the Right Greater Splanchnic Nerve for the Treatment of Heart Failure with Preserved Ejection Fraction - First-in-human Clinical Trial

Author

Shah, Sanjiv J., primary, Zirakashvili, Teona, additional, Shaburishvili, Nikoloz, additional, Shaishmelashvili, Giorgi, additional, Sievert, Horst, additional, Sievert, Kolja, additional, Bapna, Anisha, additional, Engelman, Zoar J., additional, Burkhoff, Daniel, additional, and Shaburishvili, Tamaz, additional

Published
2020
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18. Effects of selective carotid body stimulation with adenosine in conscious humans

Author

Tubek, Stanislaw, Niewinski, Piotr, Reczuch, Krzysztof, Janczak, Dariusz, Rucinski, Artur, Paleczny, Bartlomiej, Engelman, Zoar J., Banasiak, Waldemar, Paton, Julian F R, and Ponikowski, Piotr

Subjects
adenosine, carotid body, chemoreflex, peripheral chemoreceptors
Abstract

Stimulation of peripheral chemoreceptors by acute hypoxia causes an increase in minute ventilation (VI), heart rate (HR) and arterial blood pressure (BP). However, the contribution of particular chemosensory areas, such as carotid (CB) vs. aortic bodies, to this response in humans remains unknown. We performed a blinded, randomized and placebo-controlled study in 11 conscious patients (nine men, two women) undergoing common carotid artery angiography. Doses of adenosine ranging from 4 to 512 μg or placebo solution of a matching volume were administered in randomized order via a diagnostic catheter located in a common carotid artery. Separately, ventilatory and haemodynamic responses to systemic hypoxia were also assessed. Direct excitation of a CB with intra-arterial adenosine increased VI, systolic BP, mean BP and decreased HR. No responses in these variables were seen after injections of placebo. The magnitude of the ventilatory and haemodynamic responses depended on both the dose of adenosine used and on the level of chemosensitivity as determined by the ventilatory response to hypoxia. Percutaneous radiofrequency ablation of the CB abolished the adenosine evoked respiratory response and partially depressed the cardiovascular response in one participant. The results of the present study confirm the excitatory role of purines in CB physiology in humans and suggest that adenosine may be used for selective stimulation and assessment of CB activity. The trial is registered at ClinicalTrials.gov NCT01939912.

Published
2016
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19. Carotid body resection for sympathetic modulation in systolic heart failure: results from first-in-man study

Author

Niewinski, Piotr, primary, Janczak, Dariusz, additional, Rucinski, Artur, additional, Tubek, Stanislaw, additional, Engelman, Zoar J., additional, Piesiak, Pawel, additional, Jazwiec, Przemyslaw, additional, Banasiak, Waldemar, additional, Fudim, Marat, additional, Sobotka, Paul A., additional, Javaheri, Shahrokh, additional, Hart, Emma C.J., additional, Paton, Julian F.R., additional, and Ponikowski, Piotr, additional

Published
2016
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21. Dissociation between blood pressure and heart rate response to hypoxia after bilateral carotid body removal in men with systolic heart failure

Author

Niewinski, Piotr, primary, Janczak, Dariusz, additional, Rucinski, Artur, additional, Tubek, Stanislaw, additional, Engelman, Zoar J., additional, Jazwiec, Przemyslaw, additional, Banasiak, Waldemar, additional, Sobotka, Paul A., additional, Hart, Emma C. J., additional, Paton, Julian F. R., additional, and Ponikowski, Piotr, additional

Published
2013
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22. Response to Role of the Carotid Body in Obesity-Related Sympathoactivation

Author

Paton, Julian F.R., primary, Sobotka, Paul A., additional, Fudim, Marat, additional, Engelman, Zoar J., additional, Hart, Emma C.J., additional, McBryde, Fiona D., additional, Abdala, Ana P., additional, Marina, Nepthali, additional, Gourine, Alexander V., additional, Lobo, Mel, additional, Patel, Nik, additional, Burchell, Amy, additional, Ratcliffe, Laura, additional, and Nightingale, Angus, additional

Published
2013
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23. The Carotid Body as a Therapeutic Target for the Treatment of Sympathetically Mediated Diseases

Author

Paton, Julian F.R., primary, Sobotka, Paul A., additional, Fudim, Marat, additional, Engelman, Zoar J., additional, Hart, Emma C.J., additional, McBryde, Fiona D., additional, Abdala, Ana P., additional, Marina, Nepthali, additional, Gourine, Alexander V., additional, Lobo, Mel, additional, Patel, Nik, additional, Burchell, Amy, additional, Ratcliffe, Laura, additional, and Nightingale, Angus, additional

Published
2013
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26. Models for mechanistic investigations of pacing arrthymogenesis and cardiac tissue structure.

Author

Engelman ZJ, Trew ML, and Smaill BH

Subjects
Animals, Computer Simulation, Humans, Rats, Action Potentials, Arrhythmias, Cardiac physiopathology, Biological Clocks, Cardiac Pacing, Artificial methods, Disease Models, Animal, Heart Conduction System physiopathology, Models, Cardiovascular
Abstract

Two-dimensional in silico models have been constructed for investigating electrical dynamics arising due to pacing rates and tissue discontinuities. Discontinuities (structures) are introduced explicitly through flux discontinuities in the intracellular space. These models use isotropic electrophysiological properties with heterogeneity arising solely from tissue structure. Both simplified and tissue-specific structures can be used together with membrane models with varying restitution properties. Stimuli are delivered at increasing pacing rates, and solution restarts enable the investigation of repeat stimulation at any of the rates. Investigations using these models are providing new insights into mechanisms leading to conduction block and arrhythmogenesis in cardiac tissue.

Published
2008
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