Search

Your search keyword '"Engelhardt S"' showing total 498 results
Start Over Author "Engelhardt S"
498 results on '"Engelhardt S"'

4. Simulation of McKean Vlasov SDEs with super linear growth

Author

Reis, G. dos, Engelhardt, S., and Smith, G.

Subjects
Mathematics - Probability, Mathematics - Numerical Analysis, 65C05, 65C30, 65C35
Abstract

We present two fully probabilistic Euler schemes, one explicit and one implicit, for the simulation of McKean-Vlasov Stochastic Differential Equations (MV-SDEs) with drifts of super-linear growth and random initial condition. We provide a pathwise propagation of chaos result and show strong convergence for both schemes on the consequent particle system. The explicit scheme attains the standard $1/2$ rate in stepsize. From a technical point of view, we successfully use stopping times to prove the convergence of the implicit method although we avoid them altogether for the explicit one. The combination of particle interactions and random initial condition makes the proofs technically more involved. Numerical tests recover the theoretical convergence rates and illustrate a computational complexity advantage of the explicit over the implicit scheme. A comparative analysis is carried out on a stylized non-Lipschitz MV-SDE and a mean-field model for FitzHugh-Nagumo neurons. We provide numerical tests illustrating "particle corruption" effect where one single particle diverging can "corrupt" the whole particle system. Moreover, the more particles in the system the more likely this divergence is to occur., Comment: 43 pages, 4 figures, 1 Table; Final Author version (to appear in IMA Journal of Numerical Analysis)

Published
2018

5. Nicht kodierende Ribonukleinsäure im kardiovaskulären System: Sonderforschungsbereich-Transregio (SFB-TRR 267)

Author

Engelhardt, S., Dimmeler, S., Heim, C., Bär, C., Böttger, T., Boon, R., Brandes, R. P., Braun, T., Dueck, A., Gagneur, J., Grote, P., Holdt, L. M., Jaé, N., Krishnan, J., Kupatt, C., Laugwitz, K.-L., Leisegang, M. S., Maegdefessel, L., Meitinger, T., Moretti, A., Müller-McNicoll, M., Sattler, M., Schnieke, A., Schulz, M., Schunkert, H., Schwalbe, H., Teupser, D., Thum, T., Weber, C., Wittig, I., and Zarnack, K.

Published
2022
Full Text
View/download PDF

11. Why is the Winner the Best?

Author

Eisenmann, M., primary, Reinke, A., additional, Weru, V., additional, Tizabi, M. D., additional, Isensee, F., additional, Adler, T. J., additional, Ali, S., additional, Andrearczyk, V., additional, Aubreville, M., additional, Baid, U., additional, Bakas, S., additional, Balu, N., additional, Bano, S., additional, Bernal, J., additional, Bodenstedt, S., additional, Casella, A., additional, Cheplygina, V., additional, Daum, M., additional, De Bruijne, M., additional, Depeursinge, A., additional, Dorent, R., additional, Egger, J., additional, Ellis, D. G., additional, Engelhardt, S., additional, Ganz, M., additional, Ghatwary, N., additional, Girard, G., additional, Godau, P., additional, Gupta, A., additional, Hansen, L., additional, Harada, K., additional, Heinrich, M., additional, Heller, N., additional, Hering, A., additional, Huaulmé, A., additional, Jannin, P., additional, Kavur, A. E., additional, Kodym, O., additional, Kozubek, M., additional, Li, J., additional, Li, H., additional, Ma, J., additional, Martín-Isla, C., additional, Menze, B., additional, Noble, A., additional, Oreiller, V., additional, Padoy, N., additional, Pati, S., additional, Payette, K., additional, Rädsch, T., additional, Rafael-Patiño, J., additional, Bawa, V. Singh, additional, Speidel, S., additional, Sudre, C. H., additional, Van Wijnen, K., additional, Wagner, M., additional, Wei, D., additional, Yamlahi, A., additional, Yap, M. H., additional, Yuan, C., additional, Zenk, M., additional, Zia, A., additional, Zimmerer, D., additional, Aydogan, D., additional, Bhattarai, B., additional, Bloch, L., additional, Brüngel, R., additional, Cho, J., additional, Choi, C., additional, Dou, Q., additional, Ezhov, I., additional, Friedrich, C. M., additional, Fuller, C., additional, Gaire, R. R., additional, Galdran, A., additional, Faura, Á. García, additional, Grammatikopoulou, M., additional, Hong, S., additional, Jahanifar, M., additional, Jang, I., additional, Kadkhodamohammadi, A., additional, Kang, I., additional, Kofler, F., additional, Kondo, S., additional, Kuijf, H., additional, Li, M., additional, Luu, M., additional, Martinčič, T., additional, Morais, P., additional, Naser, M. A., additional, Oliveira, B., additional, Owen, D., additional, Pang, S., additional, Park, J., additional, Park, S., additional, Płotka, S., additional, Puybareau, E., additional, Rajpoot, N., additional, Ryu, K., additional, Saeed, N., additional, Shephard, A., additional, Shi, P., additional, Štepec, D., additional, Subedi, R., additional, Tochon, G., additional, Torres, H. R., additional, Urien, H., additional, Vilaça, J. L., additional, Wahid, K. A., additional, Wang, H., additional, Wang, J., additional, Wang, L., additional, Wang, X., additional, Wiestler, B., additional, Wodzinski, M., additional, Xia, F., additional, Xie, J., additional, Xiong, Z., additional, Yang, S., additional, Yang, Y., additional, Zhao, Z., additional, Maier-Hein, K., additional, Jäger, P. F., additional, Kopp-Schneider, A., additional, and Maier-Hein, L., additional

Published
2023
Full Text
View/download PDF

15. Why is the winner the best?

Author

Eisenmann, M, Reinke, A, Weru, V, Tizabi, MD, Isensee, F, Adler, TJ, Ali, S, Andrearczyk, V, Aubreville, M, Baid, U, Bakas, S, Balu, N, Bano, S, Bernal, J, Bodenstedt, S, Casella, A, Cheplygina, V, Daum, M, De Bruijne, M, Depeursinge, A, Dorent, R, Egger, J, Ellis, DG, Engelhardt, S, Ganz, M, Ghatwary, N, Girard, G, Godau, P, Gupta, A, Hansen, L, Harada, K, Heinrich, M, Heller, N, Hering, A, Huaulmé, A, Jannin, P, Kavur, AE, Kodym, O, Kozubek, M, Li, J, Li, H, Ma, J, Martín-Isla, C, Menze, B, Noble, A, Oreiller, V, Padoy, N, Pati, S, Payette, K, Rädsch, T, Rafael-Patiño, J, Bawa, VS, Speidel, S, Sudre, CH, Van Wijnen, K, Wagner, M, Wei, D, Yamlahi, A, Yap, MH, Yuan, C, Zenk, M, Zia, A, Zimmerer, D, Aydogan, D, Bhattarai, B, Bloch, L, Brüngel, R, Cho, J, Choi, C, Dou, Q, Ezhov, I, Friedrich, CM, Fuller, C, Gaire, RR, Galdran, A, García Faura, A, Grammatikopoulou, M, Hong, S, Jahanifar, M, Jang, I, Kadkhodamohammadi, A, Kang, I, Kofler, F, Kondo, S, Kuijf, H, Li, M, Luu, M, Martinčič, T, Morais, P, Naser, MA, Oliveira, B, Owen, D, Pang, S, Park, J, Park, S, Płotka, S, Puybareau, E, Rajpoot, N, Ryu, K, Saeed, N, Eisenmann, M, Reinke, A, Weru, V, Tizabi, MD, Isensee, F, Adler, TJ, Ali, S, Andrearczyk, V, Aubreville, M, Baid, U, Bakas, S, Balu, N, Bano, S, Bernal, J, Bodenstedt, S, Casella, A, Cheplygina, V, Daum, M, De Bruijne, M, Depeursinge, A, Dorent, R, Egger, J, Ellis, DG, Engelhardt, S, Ganz, M, Ghatwary, N, Girard, G, Godau, P, Gupta, A, Hansen, L, Harada, K, Heinrich, M, Heller, N, Hering, A, Huaulmé, A, Jannin, P, Kavur, AE, Kodym, O, Kozubek, M, Li, J, Li, H, Ma, J, Martín-Isla, C, Menze, B, Noble, A, Oreiller, V, Padoy, N, Pati, S, Payette, K, Rädsch, T, Rafael-Patiño, J, Bawa, VS, Speidel, S, Sudre, CH, Van Wijnen, K, Wagner, M, Wei, D, Yamlahi, A, Yap, MH, Yuan, C, Zenk, M, Zia, A, Zimmerer, D, Aydogan, D, Bhattarai, B, Bloch, L, Brüngel, R, Cho, J, Choi, C, Dou, Q, Ezhov, I, Friedrich, CM, Fuller, C, Gaire, RR, Galdran, A, García Faura, A, Grammatikopoulou, M, Hong, S, Jahanifar, M, Jang, I, Kadkhodamohammadi, A, Kang, I, Kofler, F, Kondo, S, Kuijf, H, Li, M, Luu, M, Martinčič, T, Morais, P, Naser, MA, Oliveira, B, Owen, D, Pang, S, Park, J, Park, S, Płotka, S, Puybareau, E, Rajpoot, N, Ryu, K, and Saeed, N

Abstract

International benchmarking competitions have become fundamental for the comparative performance assessment of image analysis methods. However, little attention has been given to investigating what can be learnt from these competitions. Do they really generate scientific progress? What are common and successful participation strategies? What makes a solution superior to a competing method? To address this gap in the literature, we performed a multicenter study with all 80 competitions that were conducted in the scope of IEEE ISBI 2021 and MICCAI 2021. Statistical analyses performed based on comprehensive descriptions of the submitted algorithms linked to their rank as well as the underlying participation strategies revealed common characteristics of winning solutions. These typically include the use of multi-task learning (63%) and/or multi-stage pipelines (61%), and a focus on augmentation (100%), image preprocessing (97%), data curation (79%), and post-processing (66%). The 'typical' lead of a winning team is a computer scientist with a doctoral degree, five years of experience in biomedical image analysis, and four years of experience in deep learning. Two core general development strategies stood out for highly-ranked teams: the reflection of the metrics in the method design and the focus on analyzing and handling failure cases. According to the organizers, 43% of the winning algorithms exceeded the state of the art but only 11% completely solved the respective domain problem. The insights of our study could help researchers (1) improve algorithm development strategies when approaching new problems, and (2) focus on open research questions revealed by this work.

Published
2023

16. Why is the Winner the Best?

Author

Beeldverwerking ISI, Brain, Cancer, Circulatory Health, Structure and Connections, Eisenmann, M., Reinke, A., Weru, V., Tizabi, M. D., Isensee, F., Adler, T. J., Ali, S., Andrearczyk, V., Aubreville, M., Baid, U., Bakas, S., Balu, N., Bano, S., Bernal, J., Bodenstedt, S., Casella, A., Cheplygina, V., Daum, M., De Bruijne, M., Depeursinge, A., Dorent, R., Egger, J., Ellis, D. G., Engelhardt, S., Ganz, M., Ghatwary, N., Girard, G., Godau, P., Gupta, A., Hansen, L., Harada, K., Heinrich, M., Heller, N., Hering, A., Huaulmé, A., Jannin, P., Kavur, A. E., Kodym, O., Kozubek, M., Li, J., Li, H., Ma, J., Martín-Isla, C., Menze, B., Noble, A., Oreiller, V., Padoy, N., Pati, S., Payette, K., Rädsch, T., Rafael-Patiño, J., Bawa, V. Singh, Speidel, S., Sudre, C. H., Van Wijnen, K., Wagner, M., Wei, D., Yamlahi, A., Yap, M. H., Yuan, C., Zenk, M., Zia, A., Zimmerer, D., Aydogan, D., Bhattarai, B., Bloch, L., Brüngel, R., Cho, J., Choi, C., Dou, Q., Ezhov, I., Friedrich, C. M., Fuller, C., Gaire, R. R., Galdran, A., García Faura, A., Grammatikopoulou, M., Hong, S., Jahanifar, M., Jang, I., Kadkhodamohammadi, A., Kang, I., Kofler, F., Kondo, S., Kuijf, H., Li, M., Luu, M., Martinčič, T., Morais, P., Naser, M. A., Oliveira, B., Owen, D., Pang, S., Park, J., Park, S., Płotka, S., Puybareau, E., Rajpoot, N., Ryu, K., Saeed, N., Shephard, A., Shi, P., Štepec, D., Subedi, R., Tochon, G., Torres, H. R., Urien, H., Vilaça, J. L., Wahid, K. A., Wang, H., Wang, J., Wang, L., Wang, X., Wiestler, B., Wodzinski, M., Xia, F., Xie, J., Xiong, Z., Yang, S., Yang, Y., Zhao, Z., Maier-Hein, K., Jäger, P. F., Kopp-Schneider, A., Maier-Hein, L., Beeldverwerking ISI, Brain, Cancer, Circulatory Health, Structure and Connections, Eisenmann, M., Reinke, A., Weru, V., Tizabi, M. D., Isensee, F., Adler, T. J., Ali, S., Andrearczyk, V., Aubreville, M., Baid, U., Bakas, S., Balu, N., Bano, S., Bernal, J., Bodenstedt, S., Casella, A., Cheplygina, V., Daum, M., De Bruijne, M., Depeursinge, A., Dorent, R., Egger, J., Ellis, D. G., Engelhardt, S., Ganz, M., Ghatwary, N., Girard, G., Godau, P., Gupta, A., Hansen, L., Harada, K., Heinrich, M., Heller, N., Hering, A., Huaulmé, A., Jannin, P., Kavur, A. E., Kodym, O., Kozubek, M., Li, J., Li, H., Ma, J., Martín-Isla, C., Menze, B., Noble, A., Oreiller, V., Padoy, N., Pati, S., Payette, K., Rädsch, T., Rafael-Patiño, J., Bawa, V. Singh, Speidel, S., Sudre, C. H., Van Wijnen, K., Wagner, M., Wei, D., Yamlahi, A., Yap, M. H., Yuan, C., Zenk, M., Zia, A., Zimmerer, D., Aydogan, D., Bhattarai, B., Bloch, L., Brüngel, R., Cho, J., Choi, C., Dou, Q., Ezhov, I., Friedrich, C. M., Fuller, C., Gaire, R. R., Galdran, A., García Faura, A., Grammatikopoulou, M., Hong, S., Jahanifar, M., Jang, I., Kadkhodamohammadi, A., Kang, I., Kofler, F., Kondo, S., Kuijf, H., Li, M., Luu, M., Martinčič, T., Morais, P., Naser, M. A., Oliveira, B., Owen, D., Pang, S., Park, J., Park, S., Płotka, S., Puybareau, E., Rajpoot, N., Ryu, K., Saeed, N., Shephard, A., Shi, P., Štepec, D., Subedi, R., Tochon, G., Torres, H. R., Urien, H., Vilaça, J. L., Wahid, K. A., Wang, H., Wang, J., Wang, L., Wang, X., Wiestler, B., Wodzinski, M., Xia, F., Xie, J., Xiong, Z., Yang, S., Yang, Y., Zhao, Z., Maier-Hein, K., Jäger, P. F., Kopp-Schneider, A., and Maier-Hein, L.

Published
2023

17. Myositis als postakute Folge einer COVID-19-Erkrankung?

Author

Engelhardt, S., Dislich, B., Zubler, C., Maragkou, T., Wartenberg, M., and Tzankov, A.

Abstract

Es wird über eine an COVID-19 erkrankte Patientin mit Verdacht auf eine Myositis als Folge einer SARS-CoV-2-Infektion berichtet. Initial führte wenig Information über die Krankengeschichte zur erschwerten histopathologischen Interpretation. Im Verlauf konnten weitere Details eruiert und die Diagnose einer infektassoziierten thrombotischen Mikroangiopathie im Rahmen einer Morganella-morganii-Myositis gestellt werden. Der Fall zeigt, dass auch in Zeiten der allgegenwärtigen Pandemie und selbst bei positivem COVID-19-Test Differentialdiagnosen sowie der integrative klinisch-pathologische Ansatz bei der Befundung von Muskelbiopsien nicht außer Acht gelassen werden sollten.

Published
2024
Full Text
View/download PDF

18. On-demand mitral valve morphometrics during surgical repair

Author

Grizelj Andela, Sharan Lalith, Karck Matthias, De Simone Raffaele, Romano Gabriele, and Engelhardt Sandy

Subjects
mitral valve repair, minimally invasive cardiac surgery, quantification, augmented reality, Medicine
Abstract

Mitral valve regurgitation is one of the most common heart valve diseases that can occur when the structural composition of the mitral valve is affected. Mitral valve repair, typically performed in a minimally invasive setting, is a complex surgery that aims to reinstate the structural integrity of the valve and thereby restore normal valve function. The current practice lacks quantification of geometrical changes and interactive 3D visualization that could enhance the understanding of pathomorphological changes and impact of surgical correction. This work presents functionalities from smartMVR, a quantitative tool to measure, compare, and analyse changes in mitral valve geometry from data captured on-demand using an RGB-D camera. The feasibility of the approach is demonstrated on a silicone replica of a pathological mitral valve that is iteratively corrected using common surgical techniques.

Published
2024
Full Text
View/download PDF

19. Darstellung des Entwicklungsvorgang eines praktisch umsetzbaren Technologienkonzeptes, damit das häusliche Umfeld in die Versorgungskette integriert werden kann

Author

Engelhardt, S, Mayer-Huber, S, Rauner, Y, Kastl, A, and Benstetter, F

Subjects
ddc: 610, Medicine and health
Abstract

Hintergrund: Innerhalb des Forschungsprojekts DeinHaus 4.0-Oberbayern, werden innovative Versorgungskonzepte entwickelt, damit ein selbstbestimmtes und selbständiges Leben in den eigenen vier Wänden gewährleistet werden kann. Zur Sicherstellung dieses Zieles muss das häusliche Setting [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
Full Text
View/download PDF

20. Stakeholder Bedarfs- und Bedürfnisanalyse unter Einbindung von Design Thinking Methoden in der Versorgungsforschung – eine qualitative Studie

Author

Kastl, A, Mayer-Huber, S, Engelhardt, S, Rauner, Y, and Benstetter, F

Subjects
ddc: 610, Medicine and health
Abstract

Hintergrund und Stand (inter)nationaler Forschung: „Zuhause alt werden“ ist ein weit verbreiteter Wunsch von älteren und pflegebedürftigen Menschen. Barrierefreies Wohnen, Smart-Home- und Ambient-Assisted-Living-Technologien können ältere und pflegebedürftige Menschen [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
Full Text
View/download PDF

22. Visualization and Analysis of Flow Patterns and Water Flow Simulations in Disturbed and Undisturbed Tropical Soils

Author

Bogner, C., Engelhardt, S., Zeilinger, J., Huwe, B., Caldwell, M. M., editor, Heldmaier, G., editor, Jackson, R. B., editor, Lange, O. L., editor, Mooney, H. A., editor, Schulze, E. -D., editor, Sommer, U., editor, Beck, Erwin, editor, Bendix, Jörg, editor, Kottke, Ingrid, editor, Makeschin, Franz, editor, and Mosandl, Reinhard, editor

Published
2008
Full Text
View/download PDF

26. Adrenergic System

Author

Engelhardt, S., Hein, L., Starke, K., editor, Offermanns, Stefan, editor, and Hein, Lutz, editor

Published
2004
Full Text
View/download PDF

27. Nicht kodierende Ribonukleinsäure im kardiovaskulären System:Sonderforschungsbereich-Transregio (SFB-TRR 267)

Author

Engelhardt, S., Dimmeler, S., Heim, C., Bär, C., Böttger, T., Boon, R., Brandes, R. P., Braun, T., Dueck, A., Gagneur, J., Grote, P., Holdt, L. M., Jaé, N., Krishnan, J., Kupatt, C., Laugwitz, K. L., Leisegang, M. S., Maegdefessel, L., Meitinger, T., Moretti, A., Müller-McNicoll, M., Sattler, M., Schnieke, A., Schulz, M., Schunkert, H., Schwalbe, H., Teupser, D., Thum, T., Weber, C., Wittig, I., and Zarnack, K.

Abstract

The discovery of regulatory noncoding RNA molecules (ncRNA) revolutionized our previous understanding of gene expression. As shown by extensive sequencing projects from earlier times, ncRNA occurs in the human transcriptome in a previously unforeseen number and diversity, whereas mRNA coding for proteins only makes up a small proportion of the human transcriptome. In addition to structurally important ncRNA, tens of thousands of regulatory ncRNAs were identified in humans, of which microRNAs, long noncoding RNAs and the recently discovered circular RNAs are important groups. Members of this joint project have already contributed essential knowledge on the role, the mechanisms and the target structures of ncRNAs in the cardiovascular (CV) system. Furthermore, they have shown the feasibility of treatment based on the manipulation of ncRNA in cardiovascular diseases. Although a fascinating new field of research has opened up with ncRNAs, the enormous number of RNA transcripts, their different mechanisms of action and the complex methods necessary for their investigation represent major challenges. The tasks are now 1) to determine those ncRNAs which are essential for the development and homeostasis as well as the development and progression of diseases in the cardiovascular system and 2) to mechanistically understand their mode of functioning, with the aim to derive target structures and their manipulation to develop urgently needed new therapies.

Published
2022

31. [Myositis as a post-acute sequela of COVID-19 disease? : Even in times of the pandemic, muscle biopsies can only be assessed in the context of accurate clinical information]

Author

Engelhardt, S, Dislich, B, Zubler, C, Maragkou, T, Wartenberg, M, and Tzankov, A

Subjects
570 Life sciences, biology, 610 Medicine & health
Abstract

A case of a patient suffering from COVID-19 with suspected associated myositis is reported, in which the initially limited information about the history and disease course led to difficulties in establishing a reasonable diagnosis. Through inquiry, further data could be collected, so that the diagnosis of an infection-associated thrombotic microangiopathy in the context of a Morganella morganii myositis could be made. This patient study shows that even in times of the omnipresent pandemic and despite the context of a positive COVID-19 test result, differential diagnoses and the integrative clinicopathologic approach in interpreting muscle biopsy findings should not be neglected.

Published
2022
Full Text
View/download PDF

33. Moloney Murine Leukemia Virus: A Powerful Tool to Genetically Manipulate Cardiac and Noncardiac Fibroblasts

Author

Mohr, T., additional, Schiffer, M., additional, Niemann, P., additional, Geisen, C., additional, Carls, E., additional, Mykhaylyk, O., additional, Hildebrand, S., additional, Pfeifer, A., additional, Ramanujam, D., additional, Engelhardt, S., additional, Funken, M., additional, Bakhtiary, F., additional, Fleischmann, B. K., additional, and Roell, W., additional

Published
2022
Full Text
View/download PDF

34. LifeTime and improving European healthcare through cell-based interceptive medicine

Author

Rajewsky, N., Almouzni, G., Gorski, S., Aerts, S., Amit, I., Bertero, M., Bock, C., Bredenoord, A., Cavalli, G., Chiocca, S., Clevers, H., Strooper, B., Eggert, A., Ellenberg, J., Fernández, X., Figlerowicz, M., Gasser, S., Hubner, N., Kjems, J., Knoblich, J., Krabbe, G., Lichter, P., Linnarsson, S., Marine, J., Marioni, J., Marti-Renom, M., Netea, M., Nickel, D., Nollmann, M., Novak, H., Parkinson, H., Piccolo, S., Pinheiro, I., Pombo, A., Popp, C., Reik, W., Roman-Roman, S., Rosenstiel, P., Schultze, J., Stegle, O., Tanay, A., Testa, G., Thanos, D., Theis, F., Torres-Padilla, M., Valencia, A., Vallot, C., van Oudenaarden, A., Vidal, M., Voet, T., Alberi, L., Alexander, S., Alexandrov, T., Arenas, E., Bagni, C., Balderas, R., Bandelli, A., Becher, B., Becker, M., Beerenwinkel, N., Benkirame, M., Beyer, M., Bickmore, W., Biessen, E., Blomberg, N., Blumcke, I., Bodenmiller, B., Borroni, B., Boumpas, D., Bourgeron, T., Bowers, S., Braeken, D., Brooksbank, C., Brose, N., Bruining, H., Bury, J., Caporale, N., Cattoretti, G., Chabane, N., Chneiweiss, H., Cook, S., Curatolo, P., de Jonge, M., Deplancke, B., de Witte, P., Dimmeler, S., Draganski, B., Drews, A., Dumbrava, C., Engelhardt, S., Gasser, T., Giamarellos-Bourboulis, E., Graff, C., Grün, D., Gut, I., Hansson, O., Henshall, D., Herland, A., Heutink, P., Heymans, S., Heyn, H., Huch, M., Huitinga, I., Jackowiak, P., Jongsma, K., Journot, L., Junker, J., Katz, S., Kehren, J., Kempa, S., Kirchhof, P., Klein, C., Koralewska, N., Korbel, J., Kühnemund, M., Lamond, A., Lauwers, E., Le Ber, I., Leinonen, V., Tobon, A., Lundberg, E., Lunkes, A., Maatz, H., Mann, M., Marelli, L., Matser, V., Matthews, P., Mechta-Grigoriou, F., Menon, R., Nielsen, A., Pagani, M., Pasterkamp, R., Pitkänen, A., Popescu, V., Pottier, C., Puisieux, A., Rademakers, R., Reiling, D., Reiner, O., Remondini, D., Ritchie, C., Rohrer, J., Saliba, A., Sanchez-Valle, R., Santosuosso, A., Sauter, A., Scheltema, R., Scheltens, P., Schiller, H., Schneider, A., Seibler, P., Sheehan-Rooney, K., Shields, D., Sleegers, K., Smit, A., Smith, K., Smolders, I., Synofzik, M., Tam, W., Teichmann, S., Thom, M., Turco, M., van Beusekom, H., Vandenberghe, R., den Hoecke, S., de Poel, I., van der Ven, A., van der Zee, J., van Lunzen, J., van Minnebruggen, G., Paesschen, W., van Swieten, J., van Vught, R., Verhage, M., Verstreken, P., Villa, C., Vogel, J., von Kalle, C., Walter, J., Weckhuysen, S., Weichert, W., Wood, L., Ziegler, A., Zipp, F., HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany., Medical Research Council (MRC), UK DRI Ltd, TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany., Barcelona Supercomputing Center, LifeTime Community Working Groups, Cardiology, Neurology, Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Human genetics, Rajewsky N., Almouzni G., Gorski S.A., Aerts S., Amit I., Bertero M.G., Bock C., Bredenoord A.L., Cavalli G., Chiocca S., Clevers H., De Strooper B., Eggert A., Ellenberg J., Fernandez X.M., Figlerowicz M., Gasser S.M., Hubner N., Kjems J., Knoblich J.A., Krabbe G., Lichter P., Linnarsson S., Marine J.-C., Marioni J.C., Marti-Renom M.A., Netea M.G., Nickel D., Nollmann M., Novak H.R., Parkinson H., Piccolo S., Pinheiro I., Pombo A., Popp C., Reik W., Roman-Roman S., Rosenstiel P., Schultze J.L., Stegle O., Tanay A., Testa G., Thanos D., Theis F.J., Torres-Padilla M.-E., Valencia A., Vallot C., van Oudenaarden A., Vidal M., Voet T., Alberi L., Alexander S., Alexandrov T., Arenas E., Bagni C., Balderas R., Bandelli A., Becher B., Becker M., Beerenwinkel N., Benkirame M., Beyer M., Bickmore W., Biessen E.E.A.L., Blomberg N., Blumcke I., Bodenmiller B., Borroni B., Boumpas D.T., Bourgeron T., Bowers S., Braeken D., Brooksbank C., Brose N., Bruining H., Bury J., Caporale N., Cattoretti G., Chabane N., Chneiweiss H., Cook S.A., Curatolo P., de Jonge M.I., Deplancke B., de Witte P., Dimmeler S., Draganski B., Drews A., Dumbrava C., Engelhardt S., Gasser T., Giamarellos-Bourboulis E.J., Graff C., Grun D., Gut I., Hansson O., Henshall D.C., Herland A., Heutink P., Heymans S.R.B., Heyn H., Huch M., Huitinga I., Jackowiak P., Jongsma K.R., Journot L., Junker J.P., Katz S., Kehren J., Kempa S., Kirchhof P., Klein C., Koralewska N., Korbel J.O., Kuhnemund M., Lamond A.I., Lauwers E., Le Ber I., Leinonen V., Tobon A.L., Lundberg E., Lunkes A., Maatz H., Mann M., Marelli L., Matser V., Matthews P.M., Mechta-Grigoriou F., Menon R., Nielsen A.F., Pagani M., Pasterkamp R.J., Pitkanen A., Popescu V., Pottier C., Puisieux A., Rademakers R., Reiling D., Reiner O., Remondini D., Ritchie C., Rohrer J.D., Saliba A.-E., Sanchez-Valle R., Santosuosso A., Sauter A., Scheltema R.A., Scheltens P., Schiller H.B., Schneider A., Seibler P., Sheehan-Rooney K., Shields D., Sleegers K., Smit A.B., Smith K.G.C., Smolders I., Synofzik M., Tam W.L., Teichmann S., Thom M., Turco M.Y., van Beusekom H.M.M., Vandenberghe R., Van den Hoecke S., Van de Poel I., van der Ven A., van der Zee J., van Lunzen J., van Minnebruggen G., Van Paesschen W., van Swieten J., van Vught R., Verhage M., Verstreken P., Villa C.E., Vogel J., von Kalle C., Walter J., Weckhuysen S., Weichert W., Wood L., Ziegler A.-G., Zipp F., Center for Neurogenomics and Cognitive Research, Functional Genomics, Rajewsky, N, Almouzni, G, Gorski, S, Aerts, S, Amit, I, Bertero, M, Bock, C, Bredenoord, A, Cavalli, G, Chiocca, S, Clevers, H, De Strooper, B, Eggert, A, Ellenberg, J, Fernández, X, Figlerowicz, M, Gasser, S, Hubner, N, Kjems, J, Knoblich, J, Krabbe, G, Lichter, P, Linnarsson, S, Marine, J, Marioni, J, Marti-Renom, M, Netea, M, Nickel, D, Nollmann, M, Novak, H, Parkinson, H, Piccolo, S, Pinheiro, I, Pombo, A, Popp, C, Reik, W, Roman-Roman, S, Rosenstiel, P, Schultze, J, Stegle, O, Tanay, A, Testa, G, Thanos, D, Theis, F, Torres-Padilla, M, Valencia, A, Vallot, C, van Oudenaarden, A, Vidal, M, Voet, T, Cattoretti, G, Alliance for Modulation in Epilepsy, Pharmaceutical and Pharmacological Sciences, Experimental Pharmacology, RS: Carim - H02 Cardiomyopathy, MUMC+: MA Med Staf Spec Cardiologie (9), and Cardiologie

Subjects
0301 basic medicine, Male, Artificial intelligence, Legislation, Medical, [SDV]Life Sciences [q-bio], Molecular datasets, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Cell- and Tissue-Based Therapy, Diseases, LifeTime Community Working Groups, Disease, Biomarkers, Systems biology, Health data, Pharmacology, Toxicology and Pharmaceutics(all), 0302 clinical medicine, Conjunts de dades, ethics [Delivery of Health Care], Health care, Pathology, Medicine, European healthcare, BRAIN, Single-cell multi-omics, GENE-EXPRESSION, Multidisciplinary, methods [Medicine], Education, Medical, Settore BIO/13, Intel.ligència artificial, 3. Good health, ALZHEIMERS-DISEASE, Europe, Health, Management system, Perspective, Female, ddc:500, Single-Cell Analysis, Biomarkers, Diseases, Systems biology, Complex diseases, Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC], medicine.medical_specialty, General Science & Technology, Cells, MEDLINE, cell-based interceptive medicine, LifeTime Initiative, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Clinical datasets, Artificial Intelligence, REVEALS, LifeTime Community, standards [Medicine], Humans, OMICS, RECONSTRUCTION, Intensive care medicine, trends [Medicine], trends [Delivery of Health Care], business.industry, Disease progression, standards [Delivery of Health Care], methods [Delivery of Health Care], 030104 developmental biology, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], single cell, personalized therapy, machine learning, bioinformatics, systems biology, disease, cell-based interceptive medicine, Early Diagnosis, Cardiovascular and Metabolic Diseases, Human medicine, business, Delivery of Health Care, 030217 neurology & neurosurgery, Cell based
Abstract

Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during the progression from health to disease. The analysis of large molecular and clinical datasets will identify molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. The timely detection and interception of disease embedded in an ethical and patient-centred vision will be achieved through interactions across academia, hospitals, patient associations, health data management systems and industry. The application of this strategy to key medical challenges in cancer, neurological and neuropsychiatric disorders, and infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade., The LifeTime initiative is an ambitious, multidisciplinary programme that aims to improve healthcare by tracking individual human cells during disease processes and responses to treatment in order to develop and implement cell-based interceptive medicine in Europe.

Published
2020

36. Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine (Nature, (2020), 587, 7834, (377-386), 10.1038/s41586-020-2715-9)

Author

Rajewsky, N. Almouzni, G. Gorski, S.A. Aerts, S. Amit, I. Bertero, M.G. Bock, C. Bredenoord, A.L. Cavalli, G. Chiocca, S. Clevers, H. De Strooper, B. Eggert, A. Ellenberg, J. Fernández, X.M. Figlerowicz, M. Gasser, S.M. Hubner, N. Kjems, J. Knoblich, J.A. Krabbe, G. Lichter, P. Linnarsson, S. Marine, J.-C. Marioni, J.C. Marti-Renom, M.A. Netea, M.G. Nickel, D. Nollmann, M. Novak, H.R. Parkinson, H. Piccolo, S. Pinheiro, I. Pombo, A. Popp, C. Reik, W. Roman-Roman, S. Rosenstiel, P. Schultze, J.L. Stegle, O. Tanay, A. Testa, G. Thanos, D. Theis, F.J. Torres-Padilla, M.-E. Valencia, A. Vallot, C. van Oudenaarden, A. Vidal, M. Voet, T. Alberi, L. Alexander, S. Alexandrov, T. Arenas, E. Bagni, C. Balderas, R. Bandelli, A. Becher, B. Becker, M. Beerenwinkel, N. Benkirane, M. Beyer, M. Bickmore, W.A. Biessen, E.E.A.L. Blomberg, N. Blumcke, I. Bodenmiller, B. Borroni, B. Boumpas, D.T. Bourgeron, T. Bowers, S. Braeken, D. Brooksbank, C. Brose, N. Bruining, H. Bury, J. Caporale, N. Cattoretti, G. Chabane, N. Chneiweiss, H. Cook, S.A. Curatolo, P. de Jonge, M.I. Deplancke, B. de Witte, P. Dimmeler, S. Draganski, B. Drews, A. Dumbrava, C. Engelhardt, S. Gasser, T. Giamarellos-Bourboulis, E.J. Graff, C. Grün, D. Gut, I.G. Hansson, O. Henshall, D.C. Herland, A. Heutink, P. Heymans, S.R.B. Heyn, H. Huch, M. Huitinga, I. Jackowiak, P. Jongsma, K.R. Journot, L. Junker, J.P. Katz, S. Kehren, J. Kempa, S. Kirchhof, P. Klein, C. Koralewska, N. Korbel, J.O. Kühnemund, M. Lamond, A.I. Lauwers, E. Le Ber, I. Leinonen, V. López-Tobón, A. Lundberg, E. Lunkes, A. Maatz, H. Mann, M. Marelli, L. Matser, V. Matthews, P.M. Mechta-Grigoriou, F. Menon, R. Nielsen, A.F. Pagani, M. Pasterkamp, R.J. Pitkänen, A. Popescu, V. Pottier, C. Puisieux, A. Rademakers, R. Reiling, D. Reiner, O. Remondini, D. Ritchie, C. Rohrer, J.D. Saliba, A.-E. Sanchez-Valle, R. Santosuosso, A. Sauter, A. Scheltema, R.A. Scheltens, P. Schiller, H.B. Schneider, A. Seibler, P. Sheehan-Rooney, K. Shields, D.J. Sleegers, K. Smit, A.B. Smith, K.G.C. Smolders, I. Synofzik, M. Tam, W.L. Teichmann, S.A. Thom, M. Turco, M.Y. van Beusekom, H.M.M. Vandenberghe, R. Van den Hoecke, S. van de Poel, I. van der Ven, A. van der Zee, J. van Lunzen, J. van Minnebruggen, G. van Oudenaarden, A. Van Paesschen, W. van Swieten, J.C. van Vught, R. Verhage, M. Verstreken, P. Villa, C.E. Vogel, J. von Kalle, C. Walter, J. Weckhuysen, S. Weichert, W. Wood, L. Ziegler, A.-G. Zipp, F. LifeTime Community Working Groups

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Abstract

In this Perspective, owing to an error in the HTML, the surname of author Alejandro López-Tobón of the LifeTime Community Working Groups consortium was indexed as ‘Tobon’ rather than ‘López-Tobón’ and the accents were missing. The HTML version of the original Perspective has been corrected; the PDF and print versions were always correct. © 2021, The Author(s).

Published
2021

41. LifeTime and improving European healthcare through cell-based interceptive medicine

Author

Rajewsky, N. (Nikolaus), Almouzni, G. (Geneviève), Gorski, S.A. (Stanislaw A.), Aerts, S. (Stein), Amit, I. (Ido), Bertero, M.G. (Michela G.), Bock, C. (Christoph), Bredenoord, A.L. (Annelien L.), Cavalli, G. (Giacomo), Chiocca, S. (Susanna), Clevers, H.C. (Hans), Strooper, B. (Bart) de, Eggert, A. (Angelika), Ellenberg, J. (Jan), Fernández, X.M. (Xosé M.), Figlerowicz, M. (Marek), Gasser, S.M. (Susan M.), Hübner, N. (Norbert), Kjems, J. (Jørgen), Knoblich, J.A. (Jürgen A.), Krabbe, G. (Grietje), Lichter, P. (Peter), Linnarsson, S. (Sten), Marine, J.-C. (J.), Marioni, J. (John), Marti-Renom, M.A. (Marc A.), Netea, M.G. (Mihai), Nickel, D. (Dörthe), Nollmann, M. (Marcelo), Novak, H.R. (Halina R.), Parkinson, H. (Helen), Piccolo, S. (Stefano), Pinheiro, I. (Inês), Pombo, A. (Ana), Popp, C. (Christian), Reik, W. (Wolf), Roman-Roman, S. (Sergio), Rosenstiel, P. (Philip), Schultze, J.L. (Joachim), Stegle, O. (Oliver), Tanay, A. (Amos), Testa, G. (Giuseppe), Thanos, D. (Dimitris), Theis, F. (Fabian), Torres-Padilla, M.-E. (Maria-Elena), Valencia, A. (Alfonso), Vallot, C. (Céline), van Oudenaarden, A. (Alexander), Vidal, M. (Marie), Voet, T. (Thierry), Alberi, L. (Lavinia), Alexander, S. (Stephanie), Alexandrov, T. (Theodore), Arenas, E. (Ernest), Bagni, C. (Claudia), Balderas, R. (Robert), Bandelli, A. (Andrea), Becher, B. (Burkhard), Becker, M. (Matthias), Beerenwinkel, N. (Niko), Benkirame, M. (Monsef), Beyer, M. (Marc), Bickmore, W. (Wendy), Biessen, E.E.A.L. (Erik E.A.L.), Blomberg, N. (Niklas), Blumcke, I. (Ingmar), Bodenmiller, B. (Bernd), Borroni, B. (Barbara), Boumpas, D.T. (Dimitrios T.), Bourgeron, T. (Thomas), Bowers, S. (Sarion), Braeken, D. (Dries), Brooksbank, C. (Catherine), Brose, N. (Nils), Bruining, J. (Hans), Bury, J. (Jo), Caporale, N. (Nicolo), Cattoretti, G. (Giorgio), Chabane, N. (Nadia), Chneiweiss, H. (Hervé), Cook, S.A. (Stuart A.), Curatolo, P. (Paolo), Jonge, M.I. (Marien) de, Deplancke, B. (Bart), De Strooper, B. (Bart), de Witte, P. (Peter), Dimmeler, S. (Stefanie), Draganski, B. (Bogdan), Drews, A.-D. (Anna-Dorothee), Dumbrava, C. (Costica), Engelhardt, S. (Stefan), Gasser, T. (Thomas), Giamarellos-Bourboulis, E. (Evangelos), Graff, C. (Caroline), Grün, D. (Dominic), Gut, I. (Ivo), Hansson, O. (Oskar), Henshall, D.C. (David C.), Herland, A. (Anna), Heutink, P. (Peter), Heymans, S. (Stephane), Heyn, H. (Holger), Huch, M. (Meritxell), Huitinga, I. (Inge), Jackowiak, P. (Paulina), Jongsma, K.R. (Karin), Journot, L. (Laurent), Junker, J.P. (Jan Philipp), Katz, S. (Shauna), Kehren, J. (Jeanne), Kempa, S. (Stefan), Kirchhof, P. (Paulus), Klein, C. (Christoph), Koralewska, N. (Natalia), Korbel, J.O. (Jan), Kühnemund, M. (Malte), Lamond, A.I. (Angus I.), Lauwers, E. (Elsa), Le Ber, I. (Isabelle), Leinonen, V. (Ville), Tobon, A.L. (Alejandro Lopez), Lundberg, E. (Emma), Lunkes, A. (Astrid), Maatz, H. (Henrike), Mann, M. (Mathias), Marelli, L. (Luca), Matser, V. (Vera), Matthews, P.M. (P.), Mechta-Grigoriou, F. (Fatima), Menon, R. (Radhika), Nielsen, A.F. (Anne F.), Pagani, M. (Massimiliano), Pasterkamp, R.J. (Jeroen), Pitkanen, A. (Asla), Popescu, V. (Valentin), Pottier, C. (Cyril), Puisieux, A. (Alain), Rademakers, R. (Rosa), Reiling, D. (Dory), Reiner, O. (Orly), Remondini, D. (Daniel), Ritchie, C. (Craig), Rohrer, J.D. (Jonathan D.), Saliba, A.-E. (Antione-Emmanuel), Sánchez-Valle, R. (Raquel), Santosuosso, A. (Amedeo), Sauter, A. (Arnold), Scheltema, R.A. (Richard A.), Scheltens, P. (Philip), Schiller, H.B. (Herbert B.), Schneider, A. (Anja), Seibler, P. (Philip), Sheehan-Rooney, K. (Kelly), Shields, D. (David), Sleegers, K. (Kristel), Smit, G. (Guus), Smith, K.G.C. (Kenneth G. C.), Smolders, I. (Ilse), Synofzik, M. (Matthis), Tam, W.L. (Wai Long), Teichmann, S. (Sarah), Thom, M. (Maria), Turco, M.Y. (Margherita Y.), Beusekom, H.M.M. (Heleen) van, Vandenberghe, R. (Rik), den Hoecke, S.V. (Silvie Van), Van de Poel, E. (Ellen), der Ven, A. (Andre van), van der Zee, J. (Julie), van Lunzen, J. (Jan), van Minnebruggen, G. (Geert), Van Paesschen, W. (Wim), Swieten, J.C. (John) van, van Vught, R. (Remko), Verhage, M. (Matthijs), Verstreken, P. (Patrik), Villa, C.E. (Carlo Emanuele), Vogel, J. (Jörg), Kalle, C. (Christof) von, Walter, J. (Jörn), Weckhuysen, S. (Sarah), Weichert, W. (Wilko), Wood, L. (Louisa), Ziegler, A.-G. (Anette-Gabriele), Zipp, F. (Frauke), Rajewsky, N. (Nikolaus), Almouzni, G. (Geneviève), Gorski, S.A. (Stanislaw A.), Aerts, S. (Stein), Amit, I. (Ido), Bertero, M.G. (Michela G.), Bock, C. (Christoph), Bredenoord, A.L. (Annelien L.), Cavalli, G. (Giacomo), Chiocca, S. (Susanna), Clevers, H.C. (Hans), Strooper, B. (Bart) de, Eggert, A. (Angelika), Ellenberg, J. (Jan), Fernández, X.M. (Xosé M.), Figlerowicz, M. (Marek), Gasser, S.M. (Susan M.), Hübner, N. (Norbert), Kjems, J. (Jørgen), Knoblich, J.A. (Jürgen A.), Krabbe, G. (Grietje), Lichter, P. (Peter), Linnarsson, S. (Sten), Marine, J.-C. (J.), Marioni, J. (John), Marti-Renom, M.A. (Marc A.), Netea, M.G. (Mihai), Nickel, D. (Dörthe), Nollmann, M. (Marcelo), Novak, H.R. (Halina R.), Parkinson, H. (Helen), Piccolo, S. (Stefano), Pinheiro, I. (Inês), Pombo, A. (Ana), Popp, C. (Christian), Reik, W. (Wolf), Roman-Roman, S. (Sergio), Rosenstiel, P. (Philip), Schultze, J.L. (Joachim), Stegle, O. (Oliver), Tanay, A. (Amos), Testa, G. (Giuseppe), Thanos, D. (Dimitris), Theis, F. (Fabian), Torres-Padilla, M.-E. (Maria-Elena), Valencia, A. (Alfonso), Vallot, C. (Céline), van Oudenaarden, A. (Alexander), Vidal, M. (Marie), Voet, T. (Thierry), Alberi, L. (Lavinia), Alexander, S. (Stephanie), Alexandrov, T. (Theodore), Arenas, E. (Ernest), Bagni, C. (Claudia), Balderas, R. (Robert), Bandelli, A. (Andrea), Becher, B. (Burkhard), Becker, M. (Matthias), Beerenwinkel, N. (Niko), Benkirame, M. (Monsef), Beyer, M. (Marc), Bickmore, W. (Wendy), Biessen, E.E.A.L. (Erik E.A.L.), Blomberg, N. (Niklas), Blumcke, I. (Ingmar), Bodenmiller, B. (Bernd), Borroni, B. (Barbara), Boumpas, D.T. (Dimitrios T.), Bourgeron, T. (Thomas), Bowers, S. (Sarion), Braeken, D. (Dries), Brooksbank, C. (Catherine), Brose, N. (Nils), Bruining, J. (Hans), Bury, J. (Jo), Caporale, N. (Nicolo), Cattoretti, G. (Giorgio), Chabane, N. (Nadia), Chneiweiss, H. (Hervé), Cook, S.A. (Stuart A.), Curatolo, P. (Paolo), Jonge, M.I. (Marien) de, Deplancke, B. (Bart), De Strooper, B. (Bart), de Witte, P. (Peter), Dimmeler, S. (Stefanie), Draganski, B. (Bogdan), Drews, A.-D. (Anna-Dorothee), Dumbrava, C. (Costica), Engelhardt, S. (Stefan), Gasser, T. (Thomas), Giamarellos-Bourboulis, E. (Evangelos), Graff, C. (Caroline), Grün, D. (Dominic), Gut, I. (Ivo), Hansson, O. (Oskar), Henshall, D.C. (David C.), Herland, A. (Anna), Heutink, P. (Peter), Heymans, S. (Stephane), Heyn, H. (Holger), Huch, M. (Meritxell), Huitinga, I. (Inge), Jackowiak, P. (Paulina), Jongsma, K.R. (Karin), Journot, L. (Laurent), Junker, J.P. (Jan Philipp), Katz, S. (Shauna), Kehren, J. (Jeanne), Kempa, S. (Stefan), Kirchhof, P. (Paulus), Klein, C. (Christoph), Koralewska, N. (Natalia), Korbel, J.O. (Jan), Kühnemund, M. (Malte), Lamond, A.I. (Angus I.), Lauwers, E. (Elsa), Le Ber, I. (Isabelle), Leinonen, V. (Ville), Tobon, A.L. (Alejandro Lopez), Lundberg, E. (Emma), Lunkes, A. (Astrid), Maatz, H. (Henrike), Mann, M. (Mathias), Marelli, L. (Luca), Matser, V. (Vera), Matthews, P.M. (P.), Mechta-Grigoriou, F. (Fatima), Menon, R. (Radhika), Nielsen, A.F. (Anne F.), Pagani, M. (Massimiliano), Pasterkamp, R.J. (Jeroen), Pitkanen, A. (Asla), Popescu, V. (Valentin), Pottier, C. (Cyril), Puisieux, A. (Alain), Rademakers, R. (Rosa), Reiling, D. (Dory), Reiner, O. (Orly), Remondini, D. (Daniel), Ritchie, C. (Craig), Rohrer, J.D. (Jonathan D.), Saliba, A.-E. (Antione-Emmanuel), Sánchez-Valle, R. (Raquel), Santosuosso, A. (Amedeo), Sauter, A. (Arnold), Scheltema, R.A. (Richard A.), Scheltens, P. (Philip), Schiller, H.B. (Herbert B.), Schneider, A. (Anja), Seibler, P. (Philip), Sheehan-Rooney, K. (Kelly), Shields, D. (David), Sleegers, K. (Kristel), Smit, G. (Guus), Smith, K.G.C. (Kenneth G. C.), Smolders, I. (Ilse), Synofzik, M. (Matthis), Tam, W.L. (Wai Long), Teichmann, S. (Sarah), Thom, M. (Maria), Turco, M.Y. (Margherita Y.), Beusekom, H.M.M. (Heleen) van, Vandenberghe, R. (Rik), den Hoecke, S.V. (Silvie Van), Van de Poel, E. (Ellen), der Ven, A. (Andre van), van der Zee, J. (Julie), van Lunzen, J. (Jan), van Minnebruggen, G. (Geert), Van Paesschen, W. (Wim), Swieten, J.C. (John) van, van Vught, R. (Remko), Verhage, M. (Matthijs), Verstreken, P. (Patrik), Villa, C.E. (Carlo Emanuele), Vogel, J. (Jörg), Kalle, C. (Christof) von, Walter, J. (Jörn), Weckhuysen, S. (Sarah), Weichert, W. (Wilko), Wood, L. (Louisa), Ziegler, A.-G. (Anette-Gabriele), and Zipp, F. (Frauke)

Abstract

LifeTime aims to track, understand and target human cells during the onset and progression of complex diseases and their response to therapy at single-cell resolution. This mission will be implemented through the development and integration of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during progression from health to disease. Analysis of such large molecular and clinical datasets will discover molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. Timely detection and interception of disease embedded in an ethical and patient-centered vision will be achieved through interactions across academia, hospitals, patient-associations, health data management systems and industry. Applying this strategy to key medical challenges in cancer, neurological, infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results