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231 results on '"Engelbrecht V"'

26. Diagnosis and treatment of a primary brainstem mass lesion due to Erdheim-Chester disease

Author

Marin-Laut, F, Megele, R, Engelbrecht, V, and Kleindienst, A

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Mass lesions within the brain stem constitute a diagnostic and therapeutic challenge. Even a stereotactic biopsy is associated with a high incidence of secondary neurological deficits. We report the diagnostic work-up and consecutive therapy of a young patient with a massive brain stem lesion[for full text, please go to the a.m. URL], 60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit den Benelux-Ländern und Bulgarien

Published
2009
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28. Global Estimation of Myelination in the Developing Brain on the Basis of Magnetization Transfer Imaging: A Preliminary Study

Author

Mark van Buchem, Steens, Sca, Vrooman, Ha, Zwinderman, Ah, Mcgowan, Jc, Rassek, M., and Engelbrecht, V.

Subjects
Pediatric, Male, Adolescent, Age Factors, Brain, Infant, Image Enhancement, Magnetic Resonance Imaging, Imaging, Three-Dimensional, Reference Values, Child, Preschool, Humans, Female, sense organs, Child, Myelin Sheath
Abstract

BACKGROUND AND PURPOSE: In the developing brain, myelination occurs in an orderly and predetermined sequence. The aim of this study was to determine whether such changes can be tracked using volumetric magnetization transfer imaging. METHODS: Three-dimensional magnetization transfer imaging was performed in 50 children (age range, 0.6–190 months) with no evidence of developmental delay or structural abnormalities. Volumetric magnetization transfer ratio (MTR) parameters generated of the whole brain were mean MTR and height and location of the MTR histogram peak. Relationships between volumetric MTR parameters and age were assessed using nonlinear regression analysis. RESULTS: With age, all volumetric MTR parameters changed exponentially in a way that was best expressed by the function y = a + b.exp(−x/c) (P < .0001). The peak height of the MTR histogram was the parameter that changed most predictably and that continued to change for the longest period of time. CONCLUSION: With this preliminary study, we show that by using volumetric MTR analysis, it is possible to monitor changes in the developing brain, presumably the myelination progress. This method has a potential role for detecting myelination disorders in the pediatric population, for studying the natural history of these diseases, and for monitoring the effects of treatment.

Published
2001

29. GLUT1 deficiency with delayed myelination responding to ketogenic diet.

Author

Klepper, J., Engelbrecht, V., Scheffer, H., Knaap, M.S. van der, Fiedler, A., Klepper, J., Engelbrecht, V., Scheffer, H., Knaap, M.S. van der, and Fiedler, A.

Abstract

Item does not contain fulltext, Monitoring effects of a ketogenic diet in GLUT1 deficiency syndrome without seizures is difficult. Neuroimaging is considered uninformative. We report the case of a boy with neurodevelopmental delay, severe ataxia, an E54X-mutation in the SLC2A1 gene (previously GLUT1), and neuroimaging abnormalities indicative of delayed myelination. Six months on a ketogenic diet resulted in an improved high subcortical white matter signal on T2-weighted images and a reduced N-acetylaspartate/creatine ratio. We conclude that delayed subcortical myelination may occur in GLUT1 deficiency syndrome as a nonspecific finding reflecting developmental delay. In patients without seizures, cranial magnetic resonance imaging and magnetic resonance spectroscopy may prove useful tools to monitor the response to a ketogenic diet.

Published
2007

34. Cystic leukoencephalopathy without megalencephaly: A distinct disease entity in 15 children

Author

Henneke, M., primary, Preuss, N., additional, Engelbrecht, V., additional, Aksu, F., additional, Bertini, E., additional, Bibat, G., additional, Brockmann, K., additional, Hubner, C., additional, Mayer, M., additional, Mejaski-Bosnjak, V., additional, Naidu, S., additional, Neumaier-Probst, E., additional, Rodriguez, D., additional, Weisz, W., additional, Kohlschutter, A., additional, and Gartner, J., additional

Published
2005
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