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369 results on '"Engelbert J"'

7. Dynamic Investment Games

Author

Dockner, Engelbert J., Nishimura, Kazuo, Dockner, Engelbert J., editor, Hartl, Richard F., editor, Luptačik, Mikulas, editor, and Sorger, Gerhard, editor

Published
2000
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9. Time Consistency, Subgame Perfectness, Solution Concepts and Information Patterns in Dynamic Models of Stabilization Policies

Author

Dockner, Engelbert J., Neck, Reinhard, Amman, Hans, editor, Nagurney, Anna, editor, Duraiappah, Anantha K., editor, Geweke, John, editor, Gilli, Manfred, editor, Judd, Kenneth L., editor, Kendrick, David, editor, McFadden, Daniel, editor, McGrattan, Ellen, editor, Neck, Reinhard, editor, Pagan, Adrian R., editor, Rust, John, editor, Rustem, Berc, editor, Varian, Hal R., editor, Richter, Christian, editor, and Mooslechner, Peter, editor

Published
2008
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16. Gustav Feichtinger celebrates his 70th birthday.

Author

Herbert Dawid, Engelbert J. Dockner, Richard F. Hartl, Josef L. Haunschmied, Ulrike Leopold-Wildburger, Mikulás Luptácik, Alexander Mehlmann, Alexia Prskawetz, Marion S. Rauner, Gerhard Sorger, Gernot Tragler, Vladimir M. Veliov, and Franz Wirl

Published
2010
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18. Annona muricata L. and Annona squamosa L. (Annonaceae): A review of their traditional uses and anticancer activities

Author

Virgile Ahyi, Mahunakpon Ng Gnanga, Engelbert J Agbokponto, Habib Ganfon, Fernand Gbaguidi, and Assogba Gabin Assanhou

Subjects
Traditional medicine, biology, law, Annonaceae, medicine, Cancer, Annona squamosa, Drug resistance, biology.organism_classification, Phytotherapy, medicine.disease, Annona muricata, law.invention
Abstract

Over the past century, research on cancer has increased due to the importance of the disease as sixth leading cause of mortality worldwide. Several medicines, methods and strategies have been used to cure the disease. However, the problematic of drug resistance faced by researchers and physicians before different cancer types remains a big challenge. Therefore, basic plant research has produced new bioactive compounds with promising prospects in this regard. Phytotherapy appears then as a potential alternative for the discovery of new drugs in the fight against cancer and its drug resistance.

Published
2021
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37. Cells of the human intestinal tract mapped across space and time

Author

Elmentaite, R, Kumasaka, N, Roberts, K, Fleming, A, Dann, E, King, HW, Kleshchevnikov, V, Dabrowska, M, Pritchard, S, Bolt, L, Vieira, SF, Mamanova, L, Huang, N, Perrone, F, Kai'En, IG, Lisgo, SN, Katan, M, Leonard, S, Oliver, TRW, Hook, CE, Nayak, K, Campos, LS, Conde, CD, Stephenson, E, Engelbert, J, Botting, RA, Polanski, K, van Dongen, S, Patel, M, Morgan, MD, Marioni, JC, Bayraktar, OA, Meyer, KB, He, X, Barker, RA, Uhlig, HH, Mahbubani, KT, Saeb-Parsy, K, Zilbauer, M, Clatworthy, MR, Haniffa, M, James, KR, Teichmann, SA, Elmentaite, R, Kumasaka, N, Roberts, K, Fleming, A, Dann, E, King, HW, Kleshchevnikov, V, Dabrowska, M, Pritchard, S, Bolt, L, Vieira, SF, Mamanova, L, Huang, N, Perrone, F, Kai'En, IG, Lisgo, SN, Katan, M, Leonard, S, Oliver, TRW, Hook, CE, Nayak, K, Campos, LS, Conde, CD, Stephenson, E, Engelbert, J, Botting, RA, Polanski, K, van Dongen, S, Patel, M, Morgan, MD, Marioni, JC, Bayraktar, OA, Meyer, KB, He, X, Barker, RA, Uhlig, HH, Mahbubani, KT, Saeb-Parsy, K, Zilbauer, M, Clatworthy, MR, Haniffa, M, James, KR, and Teichmann, SA

Abstract

The cellular landscape of the human intestinal tract is dynamic throughout life, developing in utero and changing in response to functional requirements and environmental exposures. Here, to comprehensively map cell lineages, we use single-cell RNA sequencing and antigen receptor analysis of almost half a million cells from up to 5 anatomical regions in the developing and up to 11 distinct anatomical regions in the healthy paediatric and adult human gut. This reveals the existence of transcriptionally distinct BEST4 epithelial cells throughout the human intestinal tract. Furthermore, we implicate IgG sensing as a function of intestinal tuft cells. We describe neural cell populations in the developing enteric nervous system, and predict cell-type-specific expression of genes associated with Hirschsprung's disease. Finally, using a systems approach, we identify key cell players that drive the formation of secondary lymphoid tissue in early human development. We show that these programs are adopted in inflammatory bowel disease to recruit and retain immune cells at the site of inflammation. This catalogue of intestinal cells will provide new insights into cellular programs in development, homeostasis and disease.

Published
2021

38. Single-cell multi-omics analysis of the immune response in COVID-19

Author

Stephenson, E, Reynolds, G, Botting, RA, Calero-Nieto, FJ, Morgan, MD, Tuong, ZK, Bach, K, Sungnak, W, Worlock, KB, Yoshida, M, Kumasaka, N, Kania, K, Engelbert, J, Olabi, B, Spegarova, JS, Wilson, NK, Mende, N, Jardine, L, Gardner, LCS, Goh, I, Horsfall, D, McGrath, J, Webb, S, Mather, MW, Lindeboom, RGH, Dann, E, Huang, N, Polanski, K, Prigmore, E, Gothe, F, Scott, J, Payne, RP, Baker, KF, Hanrath, AT, van der Loeff, ICDS, Barr, AS, Sanchez-Gonzalez, A, Bergamaschi, L, Mescia, F, Barnes, JL, Kilich, E, de Wilton, A, Saigal, A, Saleh, A, Janes, SM, Smith, CM, Gopee, N, Wilson, C, Coupland, P, Coxhead, JM, Kiselev, VY, van Dongen, S, Bacardit, J, King, HW, Rostron, AJ, Simpson, AJ, Hambleton, S, Laurenti, E, Lyons, PA, Meyer, KB, Nikolic, MZ, Duncan, CJA, Smith, KGC, Teichmann, SA, Clatworthy, MR, Marioni, JC, Gottgens, B, Haniffa, M, Stephenson, E, Reynolds, G, Botting, RA, Calero-Nieto, FJ, Morgan, MD, Tuong, ZK, Bach, K, Sungnak, W, Worlock, KB, Yoshida, M, Kumasaka, N, Kania, K, Engelbert, J, Olabi, B, Spegarova, JS, Wilson, NK, Mende, N, Jardine, L, Gardner, LCS, Goh, I, Horsfall, D, McGrath, J, Webb, S, Mather, MW, Lindeboom, RGH, Dann, E, Huang, N, Polanski, K, Prigmore, E, Gothe, F, Scott, J, Payne, RP, Baker, KF, Hanrath, AT, van der Loeff, ICDS, Barr, AS, Sanchez-Gonzalez, A, Bergamaschi, L, Mescia, F, Barnes, JL, Kilich, E, de Wilton, A, Saigal, A, Saleh, A, Janes, SM, Smith, CM, Gopee, N, Wilson, C, Coupland, P, Coxhead, JM, Kiselev, VY, van Dongen, S, Bacardit, J, King, HW, Rostron, AJ, Simpson, AJ, Hambleton, S, Laurenti, E, Lyons, PA, Meyer, KB, Nikolic, MZ, Duncan, CJA, Smith, KGC, Teichmann, SA, Clatworthy, MR, Marioni, JC, Gottgens, B, and Haniffa, M

Abstract

Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). We performed single-cell transcriptome, surface proteome and T and B lymphocyte antigen receptor analyses of over 780,000 peripheral blood mononuclear cells from a cross-sectional cohort of 130 patients with varying severities of COVID-19. We identified expansion of nonclassical monocytes expressing complement transcripts (CD16+C1QA/B/C+) that sequester platelets and were predicted to replenish the alveolar macrophage pool in COVID-19. Early, uncommitted CD34+ hematopoietic stem/progenitor cells were primed toward megakaryopoiesis, accompanied by expanded megakaryocyte-committed progenitors and increased platelet activation. Clonally expanded CD8+ T cells and an increased ratio of CD8+ effector T cells to effector memory T cells characterized severe disease, while circulating follicular helper T cells accompanied mild disease. We observed a relative loss of IgA2 in symptomatic disease despite an overall expansion of plasmablasts and plasma cells. Our study highlights the coordinated immune response that contributes to COVID-19 pathogenesis and reveals discrete cellular components that can be targeted for therapy.

Published
2021

39. Blood and immune development in human fetal bone marrow and Down syndrome

Author

Jardine, L, Webb, S, Goh, I, Londono, MQ, Reynolds, G, Mather, M, Olabi, B, Stephenson, E, Botting, RA, Horsfall, D, Engelbert, J, Maunder, D, Mende, N, Murnane, C, Dann, E, McGrath, J, King, H, Kucinski, I, Queen, R, Carey, CD, Shrubsole, C, Poyner, E, Acres, M, Jones, C, Ness, T, Coulthard, R, Elliott, N, O'Byrne, S, Haltalli, MLR, Lawrence, JE, Lisgo, S, Balogh, P, Meyer, KB, Prigmore, E, Ambridge, K, Jain, MS, Efremova, M, Pickard, K, Creasey, T, Bacardit, J, Henderson, D, Coxhead, J, Filby, A, Hussain, R, Dixon, D, McDonald, D, Popescu, D-M, Kowalczyk, MS, Li, B, Ashenberg, O, Tabaka, M, Dionne, D, Tickle, TL, Slyper, M, Rozenblatt-Rosen, O, Regev, A, Behjati, S, Laurenti, E, Wilson, NK, Roy, A, Goettgens, B, Roberts, I, Teichmann, SA, Haniffa, M, Jardine, L, Webb, S, Goh, I, Londono, MQ, Reynolds, G, Mather, M, Olabi, B, Stephenson, E, Botting, RA, Horsfall, D, Engelbert, J, Maunder, D, Mende, N, Murnane, C, Dann, E, McGrath, J, King, H, Kucinski, I, Queen, R, Carey, CD, Shrubsole, C, Poyner, E, Acres, M, Jones, C, Ness, T, Coulthard, R, Elliott, N, O'Byrne, S, Haltalli, MLR, Lawrence, JE, Lisgo, S, Balogh, P, Meyer, KB, Prigmore, E, Ambridge, K, Jain, MS, Efremova, M, Pickard, K, Creasey, T, Bacardit, J, Henderson, D, Coxhead, J, Filby, A, Hussain, R, Dixon, D, McDonald, D, Popescu, D-M, Kowalczyk, MS, Li, B, Ashenberg, O, Tabaka, M, Dionne, D, Tickle, TL, Slyper, M, Rozenblatt-Rosen, O, Regev, A, Behjati, S, Laurenti, E, Wilson, NK, Roy, A, Goettgens, B, Roberts, I, Teichmann, SA, and Haniffa, M

Abstract

Haematopoiesis in the bone marrow (BM) maintains blood and immune cell production throughout postnatal life. Haematopoiesis first emerges in human BM at 11-12 weeks after conception1,2, yet almost nothing is known about how fetal BM (FBM) evolves to meet the highly specialized needs of the fetus and newborn. Here we detail the development of FBM, including stroma, using multi-omic assessment of mRNA and multiplexed protein epitope expression. We find that the full blood and immune cell repertoire is established in FBM in a short time window of 6-7 weeks early in the second trimester. FBM promotes rapid and extensive diversification of myeloid cells, with granulocytes, eosinophils and dendritic cell subsets emerging for the first time. The substantial expansion of B lymphocytes in FBM contrasts with fetal liver at the same gestational age. Haematopoietic progenitors from fetal liver, FBM and cord blood exhibit transcriptional and functional differences that contribute to tissue-specific identity and cellular diversification. Endothelial cell types form distinct vascular structures that we show are regionally compartmentalized within FBM. Finally, we reveal selective disruption of B lymphocyte, erythroid and myeloid development owing to a cell-intrinsic differentiation bias as well as extrinsic regulation through an altered microenvironment in Down syndrome (trisomy 21).

Published
2021

40. Venture capital financed investments in intellectual capital

Author

JA[cedilla]rgensen, Steffen, Kort, Peter M., and Dockner, Engelbert J.

Subjects
Investments, Venture capital, Company investment, Company business management, Venture capital, Business, Economics
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jedc.2005.07.005 Byline: Steffen JA[cedilla]rgensen (a), Peter M. Kort (b)(c), Engelbert J. Dockner (d) Abstract: The paper considers a new company in the IT industry, founded by a management team and partially financed by venture capital. Among the questions that the paper addresses are: how much venture capital should be acquired to help finance the development of the firm? How should a wish to grow, with the aim of making a breakthrough in the IT area, be balanced against the stockholders' wish to consume? The problem is studied as an optimal control problem with a random time horizon and we derive a series of prescriptions for investment and financial decisions. Author Affiliation: (a) Department of Business and Economics, University of Southern Denmark, Odense, Denmark (b) Department of Econometrics & Operations Research and CentER, Tilburg University, Tilburg, The Netherlands (c) Department of Economics, University of Antwerp, Antwerp, Belgium (d) Department of Finance and Vienna Graduate School of Finance, University of Vienna, Vienna, Austria Article History: Received 29 March 2004; Accepted 11 July 2005

Published
2006

41. Venture capital financed investments in intellectual capital

Author

Jorgensen, Steffen, Kort, Peter M., and Dockner, Engelbert J.

Subjects
Venture capital -- Management, Computer services industry -- Management, Computer services industry -- Research, Venture capital, Computer services industry, Company business management, Business, Economics
Abstract

A research is conducted on the management of venture capital and financial decisions in information technology industry.

Published
2006

42. Cells of the human intestinal tract mapped across space and time

Author

Elmentaite, R, primary, Kumasaka, N, additional, King, HW, additional, Roberts, K, additional, Dabrowska, M, additional, Pritchard, S, additional, Bolt, L, additional, Vieira, SF, additional, Mamanova, L, additional, Huang, N, additional, Goh Kai’En, I, additional, Stephenson, E, additional, Engelbert, J, additional, Botting, RA, additional, Fleming, A, additional, Dann, E, additional, Lisgo, SN, additional, Katan, M, additional, Leonard, S, additional, Oliver, TRW, additional, Hook, CE, additional, Nayak, K, additional, Perrone, F, additional, Campos, LS, additional, Dominguez-Conde, C, additional, Polanski, K, additional, Van Dongen, S, additional, Patel, M, additional, Morgan, MD, additional, Marioni, JC, additional, Bayraktar, OA, additional, Meyer, KB, additional, Zilbauer, M, additional, Uhlig, H, additional, Clatworthy, MR, additional, Mahbubani, KT, additional, Saeb Parsy, K, additional, Haniffa, M, additional, James, KR, additional, and Teichmann, SA, additional

Published
2021
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43. Capital accumulation games with a non-concave production function

Author

Dockner, Engelbert J. and Nishimura, Kazuo

Subjects
Capital formation -- Analysis, Markov processes -- Analysis, Business, Economics
Abstract

The analysis of two different capital accumulation games and their corresponding equilibrium, with reference to an economy with a single stock are furnished.

Published
2005

48. The effects of long-term debt on a firm's new product pricing policy in duopolistic markets

Author

Baldauf, Artur, Dockner, Engelbert J., and Reisinger, Heribert

Subjects
Debt financing (Corporations) -- Research, Duopolies -- Research, New products -- Prices and rates, Business, Business, general
Abstract

A new study examines how a company's new product pricing policy in a duopolistic market structure is affected by long-term debt.

Published
2000

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