659 results on '"Engel, James Douglas"'
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2. The abundance of the short GATA1 isoform affects megakaryocyte differentiation and leukemic predisposition in mice
3. TR4 and BCL11A repress γ-globin transcription via independent mechanisms
4. Murine erythroid differentiation kinetics in vivo under normal and anemic stress conditions
5. Decoding the pathogenesis of Diamond–Blackfan anemia using single-cell RNA-seq
6. A new murine Rpl5 (uL18) mutation provides a unique model of variably penetrant Diamond-Blackfan anemia
7. Gata2 heterozygous mutant mice exhibit reduced inflammatory responses and impaired bacterial clearance
8. In situ mapping identifies distinct vascular niches for myelopoiesis
9. Hemodynamic regulation of perivalvular endothelial gene expression prevents deep venous thrombosis
10. UNC0638 induces high levels of fetal hemoglobin expression in β-thalassemia/HbE erythroid progenitor cells
11. Understanding Distal Transcriptional Regulation from Sequence Motif, Network Inference and Interactome Perspectives
12. Understanding Transcriptional Regulation Using De-novo Sequence Motif Discovery, Network Inference and Interactome Data
13. Finding Sequence Features in Tissue-specific Sequences
14. Reactivation of Fetal Hemoglobin for Treating β-Thalassemia and Sickle Cell Disease
15. Oral administration of the LSD1 inhibitor ORY-3001 increases fetal hemoglobin in sickle cell mice and baboons
16. Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development
17. The orphan nuclear receptor TR4 regulates erythroid cell proliferation and maturation
18. Genomic Imprinting Recapitulated in the Human β-Globin Locus
19. Small Maf Proteins Serve as Transcriptional Cofactors for Keratinocyte Differentiation in the Keap1-Nrf2 Regulatory Pathway
20. GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis
21. The Aγ -globin 3 ′ Element Provides no Unique Function(s) for Human β -globin Locus Gene Regulation
22. GATA-1 Transcription is Controlled by Distinct Regulatory Mechanisms during Primitive and Definitive Erythropoiesis
23. Mutation of Gene-Proximal Regulatory Elements Disrupts Human ε -, γ -, and β -globin Expression in Yeast Artificial Chromosome Transgenic Mice
24. The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice
25. Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genes
26. Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation
27. Identification of Novel Regulators of Erythropoiesis Using Whole-Genome CRISPR-Cas9 Screening
28. p53-Independent Pathways in Diamond Blackfan Anemia
29. GATA1 and GATA2 Function in Hematopoietic Differentiation
30. Long non-coding RNA-dependent mechanism to regulate heme biosynthesis and erythrocyte development
31. Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs
32. Identification of novel γ-globin inducers among all potential erythroid druggable targets
33. TRIM28 is essential for erythroblast differentiation in the mouse
34. GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry
35. Thalassaemia
36. Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes
37. Combinatorial Gata2 and Sca1 Expression Defines Hematopoietic Stem Cells in the Bone Marrow Niche
38. SEC23A rescues SEC23B-deficient congenital dyserythropoietic anemia type II
39. An erythroid-to-myeloid cell fate conversion is elicited by LSD1 inactivation
40. A new murineRpl5(uL18) mutation provides a unique model of variably penetrant Diamond-Blackfan anemia
41. GATA3 is essential for separating patterning domains during facial morphogenesis
42. Expression of Cytoskeletal Protein 4.1 during Avian Erythroid Cellular Maturation
43. Isolation of Recombinant cDNAs Encoding Chicken Erythroid δ -aminolevulinate Synthase
44. The Chicken β/ε-Globin Enhancer Directs Autonomously Regulated, High-Level Expression of the Chicken ε-Globin Gene in Transgenic Mice
45. Expression of δ -aminolevulinate Synthase in Avian Cells: Separate Genes Encode Erythroid-Specific and Nonspecific Isozymes
46. Analysis of the Closely Linked Adult Chicken α -Globin Genes in Recombinant DNAs
47. An Unusual 5 ′ Splice Sequence is Efficiently Utilized in vivo
48. Unusual Structure of the Chicken Embryonic α -globin Gene, π ′
49. Histone Genes are Clustered but not Tandemly Repeated in the Chicken Genome
50. Adult Chicken α -globin Genes, α A and α D : No Anemic Shock α -globin Exists in Domestic Chickens
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