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1. Association of Fluid Balance and Hemoglobin Decline With Neurological Outcome After Aneurysmal Subarachnoid Hemorrhage

Author

Truckenmueller, Peter, Wolf, Stefan, Wasilewski, David, Vajkoczy, Peter, Früh, Anton, Baro, Norbert, Bauer, Miriam, Barner, Christoph, Dengler, Nora F., von Dincklage, Falk, Finger, Tobias, Francis, Roland, Hotter, Benjamin, Hunsicker, Oliver, Jussen, Daniel, Jüttler, Eric, Pohrt, Anne, Salih, Farid, Schaumann, Andreas, Witsch, Jens, Nagel, Christoph, Lemcke, Johannes, Meier, Ullrich, Podlesik, Dino, Schackert, Gabriele, Juratli, Tareq A., Huttner, Hagen, Schwab, Stefan, Staykov, Dimitre, Hagedorn, Sabine, Müller, Daniela, Müller, Oliver, Sarge, Robert, Sure, Ulrich, Bardutzky, Jürgen, Niesen, Wolf-Dirk, Lange, Katharina, Malinova, Vesna, Mielke, Dorothee, Rohde, Veit, Päsler, Dennis, Reinhardt, Stephanie, Schroeder, Henry W.S., Czorlich, Patrick, Regelsberger, Jan, Sauvigny, Thomas, Westphal, Manfred, Ehlert, Angelika, Gremmer, Rudolf, Beyer, Christian, Beyer, Desiree, Huthmann, Alexandra, Kerz, Thomas, Landscheidt, Julia, Schürer, Ludwig, Schul, David B., Meyer, Bernhard, Ryang, Yu-Mi, Toeroek, Elisabeth, Wostrack, Maria, Arouk, Wasim, Al-Jehani, Hosam, Fritsch, Michael, Al-Jehani, Hosam, Alturk, Abdulrahman Y., Sinclair, David B., Beck, Jürgen, Fung, Christian, Soell, Nicole, Engel, Doortje C., Hildebrandt, Gerhard, Huscher, Karen, Lange, Heidrun, Hutchinson, Peter, and Tseng, Ming-Yuan

Published
2024
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2. Parenthood and neurosurgery in Europe, a white paper from the European association of neurosurgical societies’ diversity in neurosurgery committee, part II – practice with children

Author

Janz, Claudia, Hadelsberg, Uri Pinchas, Broekman, Marike, Cavallo, Claudio, Engel, Doortje, Majernik, Gökce Hatipoglu, Hoellig, Anke, Ilic, Tijana, Jeltema, Hanne-Rinck, Mielke, Dorothee, Rodríguez-Hernández, Ana, Ryang, Yu-Mi, Fozia, Saeed, Syrmos, Nikolaos, Vanchaze, Kristel, Vayssiere, Pia, and Hernandez-Duran, Silvia

Published
2024
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4. Parenthood and neurosurgery in Europe a white paper from the European Association of Neurosurgical Societies’ Diversity in Neurosurgery Committee Part I – Family Planning and Practice during Pregnancy

Author

Vayssiere, Pia, Broekman, Marike, Cavallo, Claudio, Engel, Doortje, Hadelsberg, Uri Pinchas, Majernik, Gökce Hatipoglu, Hoellig, Anke, Ilic, Tijana, Janz, Claudia, Jeltema, Hanne-Rinck, Mielke, Dorothee, Rodríguez-Hernández, Ana, Ryang, Yu-Mi, Fozia, Saeed, Syrmos, Nikolaos, Vanchaze, Kristel, and Hernandez-Duran, Silvia

Published
2023
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8. Parenthood and neurosurgery in Europe, a white paper from the European association of neurosurgical societies’ diversity in neurosurgery committee, part II – practice with children

Author

Vayssiere, Pia, primary, Broekman, Marike, additional, Cavallo, Claudio, additional, Engel, Doortje, additional, Hadelsberg, Uri Pinchas, additional, Majernik, Gökce Hatipoglu, additional, Hoellig, Anke, additional, Ilic, Tijana, additional, Janz, Claudia, additional, Jeltema, Hanne-Rinck, additional, Mielke, Dorothee, additional, Rodríguez-Hernández, Ana, additional, Ryang, Yu-Mi, additional, Fozia, Saeed, additional, Syrmos, Nikolaos, additional, Vanchaze, Kristel, additional, and Hernandez-Duran, Silvia, additional

Published
2023
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12. Sequencing of SARS-CoV-2 RNA Fragments in Wastewater Detects the Spread of New Variants during Major Events

Author

Zhakparov, Damir; https://orcid.org/0000-0001-7175-0843, Quirin, Yves, Xiao, Yi, Battaglia, Nicole, Holzer, Michael, Bühler, Martin, Kistler, Walter; https://orcid.org/0000-0002-9289-6953, Engel, Doortje, Zumthor, Jon Paulin, Caduff, Alexa; https://orcid.org/0000-0002-9008-6148, Baerenfaller, Katja; https://orcid.org/0000-0002-1904-9440, Zhakparov, Damir; https://orcid.org/0000-0001-7175-0843, Quirin, Yves, Xiao, Yi, Battaglia, Nicole, Holzer, Michael, Bühler, Martin, Kistler, Walter; https://orcid.org/0000-0002-9289-6953, Engel, Doortje, Zumthor, Jon Paulin, Caduff, Alexa; https://orcid.org/0000-0002-9008-6148, and Baerenfaller, Katja; https://orcid.org/0000-0002-1904-9440

Abstract

The sequencing of SARS-CoV-2 RNA in wastewater is an unbiased method to detect the spread of emerging variants and to track regional infection dynamics, which is especially useful in case of limited testing and clinical sequencing. To test how major international events influence the spread of new variants we have sequenced SARS-CoV-2 RNA in the wastewater samples of Davos, Landquart, Lostallo, and St. Moritz in the Swiss canton of Grisons in the time around the international sports competitions in Davos and St. Moritz in December 2021, and additionally in May 2022 and January 2023 in Davos and St. Moritz during the World Economic Forum (WEF) in Davos. The prevalence of the variants identified from the wastewater sequencing data showed that the Omicron variant BA.1 had spread in Davos and St. Moritz during the international sporting events hosted there in December 2021. This spread was associated with an increase in case numbers, while it was not observed in Landquart and Lostallo. Another instance of new variant spread occurred during the WEF in January 2023, when the Omicron variant BA.2.75 arrived in Davos but not in St. Moritz. We can therefore conclude that major international events promote the spread of new variants in the respective host region, which has important implications for the protective measures that should be taken.

Published
2023

14. Effectiveness of Lumbar Cerebrospinal Fluid Drain Among Patients With Aneurysmal Subarachnoid Hemorrhage: A Randomized Clinical Trial

Author

Wolf, Stefan, Mielke, Dorothee, Barner, Christoph, Malinova, Vesna, Kerz, Thomas, Wostrack, Maria, Czorlich, Patrick, Salih, Farid, Engel, Doortje C, Ehlert, Angelika, Staykov, Dimitre, Alturki, Abdulrahman Y, Sure, Ulrich, Bardutzky, Jürgen, Schroeder, Henry W S, Schürer, Ludwig, Beck, Jürgen, Juratli, Tareq A, Fritsch, Michael, Lemcke, Johannes, Pohrt, Anne, Meyer, Bernhard, Schwab, Stefan, Rohde, Veit, and Vajkoczy, Peter

Subjects
610 Medicine & health
Abstract

IMPORTANCE After aneurysmal subarachnoid hemorrhage, the use of lumbar drains has been suggested to decrease the incidence of delayed cerebral ischemia and improve long-term outcome. OBJECTIVE To determine the effectiveness of early lumbar cerebrospinal fluid drainage added to standard of care in patients after aneurysmal subarachnoid hemorrhage. DESIGN, SETTING, AND PARTICIPANTS The EARLYDRAIN trial was a pragmatic, multicenter, parallel-group, open-label randomized clinical trial with blinded end point evaluation conducted at 19 centers in Germany, Switzerland, and Canada. The first patient entered January 31, 2011, and the last on January 24, 2016, after 307 randomizations. Follow-up was completed July 2016. Query and retrieval of data on missing items in the case report forms was completed in September 2020. A total of 20 randomizations were invalid, the main reason being lack of informed consent. No participants meeting all inclusion and exclusion criteria were excluded from the intention-to-treat analysis. Exclusion of patients was only performed in per-protocol sensitivity analysis. A total of 287 adult patients with acute aneurysmal subarachnoid hemorrhage of all clinical grades were analyzable. Aneurysm treatment with clipping or coiling was performed within 48 hours. INTERVENTION A total of 144 patients were randomized to receive an additional lumbar drain after aneurysm treatment and 143 patients to standard of care only. Early lumbar drainage with 5 mL per hour was started within 72 hours of the subarachnoid hemorrhage. MAIN OUTCOMES AND MEASURES Primary outcome was the rate of unfavorable outcome, defined as modified Rankin Scale score of 3 to 6 (range, 0 to 6), obtained by masked assessors 6 months after hemorrhage. RESULTS Of 287 included patients, 197 (68.6%) were female, and the median (IQR) age was 55 (48-63) years. Lumbar drainage started at a median (IQR) of day 2 (1-2) after aneurysmal subarachnoid hemorrhage. At 6 months, 47 patients (32.6%) in the lumbar drain group and 64 patients (44.8%) in the standard of care group had an unfavorable neurological outcome (risk ratio, 0.73; 95% CI, 0.52 to 0.98; absolute risk difference, -0.12; 95% CI, -0.23 to -0.01; P = .04). Patients treated with a lumbar drain had fewer secondary infarctions at discharge (41 patients [28.5%] vs 57 patients [39.9%]; risk ratio, 0.71; 95% CI, 0.49 to 0.99; absolute risk difference, -0.11; 95% CI, -0.22 to 0; P = .04). CONCLUSION AND RELEVANCE In this trial, prophylactic lumbar drainage after aneurysmal subarachnoid hemorrhage lessened the burden of secondary infarction and decreased the rate of unfavorable outcome at 6 months. These findings support the use of lumbar drains after aneurysmal subarachnoid hemorrhage. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT01258257.

Published
2023
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19. Results from Canton Grisons of Switzerland Suggest Repetitive Testing Reduces SARS-CoV-2 Incidence (February-March 2021)

Author

Gorji, Hossein, primary, Lunati, Ivan, additional, Rudolf, Fabian, additional, Vidondo, Beatriz, additional, Hardt, Wolf-Dietrich, additional, Jenny, Patrick, additional, Engel, Doortje, additional, Schneider, Jörg, additional, Jamnicki, Marina, additional, Leuthold, Rudolf, additional, Risch, Lorenz, additional, Risch, Martin, additional, Bühler, Martin, additional, Sommer, Adrian, additional, and Caduff, Alexa, additional

Published
2021
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20. A basic model for training of microscopic and endoscopic transsphenoidal pituitary surgery: the Egghead

Author

Engel, Doortje, Ferrari, Andrea, Tasman, Abel-Jan, Schmid, Raphael, Schindel, Ralf, Haile, Sarah, Mariani, Luigi, Fournier, Jean-Yves, Engel, Doortje, Ferrari, Andrea, Tasman, Abel-Jan, Schmid, Raphael, Schindel, Ralf, Haile, Sarah, Mariani, Luigi, and Fournier, Jean-Yves

Abstract

Background: Transsphenoidal endoscopic surgery has gained popularity in the last 2 decades and is becoming a standard technique for resection of pituitary adenomas. In contrast to their ENT colleagues, neurosurgical residents have practically no endoscopic experience when they reach the training stage for transsphenoidal procedures. We have developed an affordable method for repetitive training in endoscopic (and microscopic) work in a narrow channel, allowing training of the basic movements needed for resection of pituitary adenoma. Methods: In collaboration with colleagues in the ENT Department, Cantonal Hospital St. Gall, and the Technical University of Zurich, a three-dimensional model of the nasal cavity was developed and patented. The Egghead model consists of a 3D synthetic reconstruction of the head nasal cavity and sphenoid sinus. A boiled egg represents the sella. For validation, 17 neurosurgical residents from the Department of Neurosurgery, University Hospital of Basel, and Department of Neurosurgery, Cantonal Hospital of St. Gall, St. Gall, Switzerland, and two experts performed a standardized procedure mimicking a transsphenoidal pituitary procedure by dissecting a corridor to the egg yolk and resecting it, respecting the surrounding egg white. This procedure was performed under both microscopic and video-endoscopic visualization. A score for the precision and speed of the surgical performance was developed and used. Results: The model allows repetitive training of the resection of the egg yolk under sparing of the egg white after careful opening of the shell. The validation data showed a steeper learning curve using the endoscopic technique than performing the same task using the microscope. After three repetitions, the quality of resection was better with the endoscopic technique. Conclusions: Our model, the Egghead, is affordable, offers tactile feedback and allows infinite repetitions in basic training for pituitary surgery. It can be used for trai

Published
2021

22. Contributors

Author

Aarabi, Bizhan, primary, Abbott, Rick, additional, Abdulrauf, Saleem I., additional, Acosta, Frank L., additional, Adler, John R., additional, Agazaryan, Nzhde, additional, Aghi, Manish, additional, Ahn, Edward S., additional, Alaraj, Ali, additional, Albert, Gregory W., additional, Albright, Leland, additional, Albuquerque, Felipe C., additional, Alden, Tord D., additional, Alexander, Michael J., additional, Alexandrov, Andrei V., additional, Al-Mefty, Ossama, additional, Alterman, Ron L., additional, Álvarez, Lázaro, additional, Amankulor, Nduka M., additional, Amenta, Peter S., additional, Ames, Christopher P., additional, Amin-Hanjani, Sepideh, additional, Ammirati, Mario, additional, Anderson, Carryn, additional, Anderson, Richard C.E., additional, Anderson, William S., additional, Angevine, Peter D., additional, Arif, Hiba, additional, Arle, Jeffrey E., additional, Armonda, Rocco, additional, Arnold, Paul M., additional, Asadi-Moghaddam, Kaveh, additional, Asghar, Ferhan A., additional, Ashley, William W., additional, Aydin, Sabri, additional, Aygun, Nafi, additional, Baehring, Joachim M., additional, Bagley, Jacob H., additional, Bahgat, Diaa, additional, Bailes, Julian E., additional, Ball, Jonathon R., additional, Baltuch, Gordon H., additional, Bambakidis, Nicholas C., additional, Baraban, Scott C., additional, Barani, Igor J., additional, Barbaro, Nicholas M., additional, Barker, Frederick G., additional, Barnett, Gene H., additional, Barnwell, Stanley L., additional, Barone, Constance M., additional, Barrow, Daniel L., additional, Bartolomei, Fabrice, additional, Bartolomei, Juan, additional, Batchelor, Tracy T., additional, Batjer, H. Hunt, additional, Bauer, Andrew M., additional, Bauman, Joel A., additional, Baumann, Thomas K., additional, Baumgartner, James E., additional, Bayouth, John, additional, Beaumont, Andrew, additional, Bederson, Joshua B., additional, Beisse, Rudolf, additional, Bell, Randy S., additional, Belzberg, Allan, additional, Benabid, Alim Louis, additional, Benarroch, Eduardo E., additional, Benazzouz, Abdelhamid, additional, Bendok, Bernard R., additional, Benzel, Edward C., additional, Berenstein, Alejandro, additional, Berger, Mitchel S., additional, Bergsneider, Marvin, additional, Bertalanffy, Helmut, additional, Bhalla, Tarun, additional, Bidros, Dani S., additional, Biller, José, additional, Bilsky, Mark H., additional, Binder, Devin K., additional, Bingaman, William, additional, Birch, Rolfe, additional, Bishop, Allen T., additional, Black, Peter M., additional, Blount, Jeffrey P., additional, Blumbergs, Peter C., additional, Bohman, Leif-Erik, additional, Boomsaad, Zackary E., additional, Boop, Frederick A., additional, Bou-Haidar, Pascal, additional, Boué, Daniel R., additional, Bourgeois, Blaise F.D., additional, Bowman, Robin M., additional, Bozinov, Oliver, additional, Bramlett, Helen M., additional, Brem, Henry, additional, Brem, Steven, additional, Britz, Gavin W., additional, Brockmeyer, Douglas L., additional, Brooks, David J., additional, Browd, Samuel R., additional, Brown, Paul D., additional, Brown, Robert D., additional, Bruce, Jeffrey N., additional, Brunstrom-Hernandez, Janice E., additional, Buatti, John, additional, Bullock, M. Ross, additional, Burchiel, Kim J., additional, Burger, Peter C., additional, Bussière, Marc R., additional, Bydon, Mohamad, additional, Byrne, Richard W., additional, Calcagnotto, Maria Elisa, additional, Campbell, Victoria A., additional, Campbell, William, additional, Cannon, George M., additional, Caragine, Louis P., additional, Carson, Benjamin S., additional, Cascino, Gregory D., additional, Cascio, Ethan, additional, Castinetti, Frédéric, additional, Cawley, C. Michael, additional, Cetas, Justin S., additional, Chabardès, Stéphan, additional, Chang, Edward F., additional, Chang, Eric C., additional, Chang, Eric L., additional, Chang, Steven D., additional, Chang, Steven W., additional, Chang, Susan M., additional, Chao, Kevin, additional, Chapman, Paul H., additional, Charbel, Fady T., additional, Chauvel, Patrick, additional, Chen, Grace, additional, Cheng, Boyle C., additional, Cheng, Joseph S., additional, Chern, Joshua J., additional, Chiocca, E. Antonio, additional, Choutka, Ondrej, additional, Chowdhry, Shakeel A., additional, Christian, Cindy W., additional, Chuang, Kathy, additional, Claassen, Jan, additional, Clatterbuck, Richard E., additional, Claus, Elizabeth B., additional, Cleary, Daniel R., additional, Coffey, Robert J., additional, Cohen, Alan R., additional, Cole, Andrew J., additional, Connolly, E. Sander, additional, Connolly, Patrick J., additional, Copay, Anne G., additional, Coppens, Jeroen R., additional, Corbett, James J., additional, Corcos, Daniel M., additional, Coric, Domagoj, additional, Cosgrove, Garth Rees, additional, Couldwell, William T., additional, Craig, Stirling, additional, Crawford, Neil R., additional, Crino, Peter B., additional, Crowley, R. Webster, additional, Curt, Bradford A., additional, Czosnyka, Marek, additional, Czosnyka, Zofia, additional, Dadashev, Vladimir Y., additional, Dailey, Andrew T., additional, Danan, Deepa, additional, Danish, Shabbar F., additional, Dashti, Shervin R., additional, David, Carlos A., additional, David, David J., additional, Day, Arthur L., additional, De Salles, Antonio A.F., additional, Dehdashti, Amir R., additional, Del Brutto, Oscar H., additional, Delashaw, Johnny B., additional, Delman, Bradley, additional, DeLong, Mahlon R., additional, DeMonte, Franco, additional, Dhall, Sanjay S., additional, Dias, Mark S., additional, Dickman, Curtis A., additional, Dietrich, W. Dalton, additional, DiLuna, Michael L., additional, Di Meco, Francesco, additional, Dirks, Peter, additional, Dixon, C. Edward, additional, Donoghue, Jacob A., additional, Dorward, Ian G., additional, Doshi, Amish H., additional, Drake, James, additional, Drzymalski, Dan, additional, Du, Rose, additional, Ducruet, Andrew, additional, Duhaime, Ann-Christine, additional, Dumont, Aaron S., additional, Duntsch, Christopher D., additional, Dusick, Joshua R., additional, Dyve, Suzan, additional, Eberwine, James, additional, Eboli, Paula, additional, Ecker, Robert D., additional, Edwards, Richard J., additional, Eichler, Marc E., additional, Engel, Doortje C., additional, Epstein, Nancy E., additional, Ewend, Matthew G., additional, Farhat, Hamad, additional, Farrell, Christopher J., additional, Fehlings, Michael G., additional, Feiz-Erfan, Iman, additional, Feldstein, Neil A., additional, Fessler, Richard G., additional, Figueroa, Juan J., additional, Filler, Aaron G., additional, Findlay, J. Max, additional, Finn, Michael A., additional, Fiorella, David J., additional, Fisher, James L., additional, Fisher, Robert S., additional, Flamm, Eugene S., additional, Fleck, James D., additional, Flemming, Kelly D., additional, Flickinger, John C., additional, Flores-Sarnat, Laura, additional, Follett, Kenneth A., additional, Foote, Kelly D., additional, Fourney, Daryl R., additional, Fraix, Valerie, additional, Frazier, James L., additional, Fried, Itzhak, additional, Friedman, Allan H., additional, Friedman, William A., additional, Friehs, Gerhard M., additional, Fry, Donald E., additional, Fuller, Gregory N., additional, Garcia, Hector H., additional, Gardner, Paul A., additional, Garrett, Mark, additional, Garton, Hugh, additional, Gavin, Cormac G., additional, Gean, Alisa D., additional, Gennarelli, Thomas A., additional, Gerganov, Venelin, additional, Germanwala, Anand V., additional, Gerosa, Massimo, additional, Gerstner, Elizabeth R., additional, Gerszten, Peter C., additional, Ghatan, Saadi, additional, Ghostine, Samer, additional, Giannotta, Steven, additional, Gigante, Paul R., additional, Gilliam, Frank, additional, Gilmer-Hill, Holly, additional, Gjedde, Albert, additional, Glick, Roberta P., additional, Gokaslan, Ziya L., additional, Gologorsky, Yakov, additional, Golshani, Kiarash, additional, Gonzalez, Nestor R., additional, Goodrich, James Tait, additional, Gordon, Tessa, additional, Gorgulho, Alessandra A., additional, Goumnerova, Liliana C., additional, Grady, M. Sean, additional, Grafman, Jordan, additional, Grand, Sylvie, additional, Grant, Gerald A., additional, Graziano, Gregory P., additional, Greenberg, Benjamin, additional, Guest, James, additional, Guha, Abhijit, additional, Günel, Murat, additional, Gupta, Gaurav, additional, Gupta, Nalin, additional, Guridi, Jorge, additional, Guthrie, Barton L., additional, Haddad, Georges F., additional, Haglund, Michael M., additional, Haid, Regis W., additional, Haines, Stephen J., additional, Hamani, Clement, additional, Hamilton, Bronwyn E., additional, Hamilton, D. Kojo, additional, Hankinson, Todd C., additional, Happel, Leo T., additional, Haq, Ihtsham Ul, additional, Haque, Raqeeb, additional, Harbaugh, Robert E., additional, Harraher, Ciara D., additional, Harris, Leo, additional, Harrop, James S., additional, Hassaneen, Wael, additional, Hawkins, Cynthia, additional, Hawryluk, Gregory W.J., additional, Haynes, Neal G., additional, Heary, Robert F., additional, Heimberger, Amy B., additional, Heinricher, Mary M., additional, Hemmen, Thomas M., additional, Henderson, Jaimie M., additional, Heros, Roberto C., additional, Herrup, Karl, additional, Hervey-Jumper, Shawn L., additional, Heuer, Gregory G., additional, Hirsch, Lawrence J., additional, Hirschl, Robert, additional, Hoh, Brian L., additional, Hoh, Daniel J., additional, Holland, Eric C., additional, Holtzheimer, Paul E., additional, Hopkins, L. Nelson, additional, Horner, Philip J., additional, Hovda, David A., additional, Howard, Matthew A., additional, Hsieh, Patrick, additional, Hu, Yin C., additional, Hua, Sherwin E., additional, Huang, Jason H., additional, Huang, Judy, additional, Hughes, Samuel A., additional, Huisman, Thierry A.G.M., additional, Hunt, Matthew A., additional, Hurlbert, R. John, additional, Hurst, Robert W., additional, Huttner, Anita, additional, Hwang, Steven W., additional, Isaias, Ioannis U., additional, Iskandar, Bermans J., additional, Jacob, Arun, additional, Jaeckle, Kurt A., additional, Jagannathan, Jay, additional, Jakacki, Regina I., additional, Jallo, George I., additional, Jane, John A., additional, Janicki, Ryan, additional, Janigro, Damir, additional, Jeelani, N u Owase, additional, Jellinger, Kurt A., additional, Jenkins, Arthur L., additional, Jernigan, Sarah, additional, Jimenez, David F., additional, Johanson, Conrad E., additional, Johnson, J. Patrick, additional, Johnson, Matthew D., additional, Jones, G. Alexander, additional, Jutla, Rajni K., additional, Kainth, Koijan Singh, additional, Kaiser, Michael G., additional, Kakarla, U. Kumar, additional, Kalfas, Iain H., additional, Kalnins, Aleksandrs Uldis, additional, Kano, Hideyuki, additional, Kanpolat, Yucel, additional, Kanter, Adam S., additional, Karimi, Reza J., additional, Kassam, Amin B., additional, Kaufman, Bruce A., additional, Kaufman, Christian B., additional, Kawasaki, Hiroto, additional, Kelley, Brian C., additional, Kellner, Christopher P., additional, Keong, Nicole C., additional, Kestle, John R.W., additional, Khalessi, Alexander A., additional, Khan, Nadia, additional, Khurana, Vini G., additional, Kim, Daniel H., additional, Kim, Dong Gyu, additional, Kim, Dong H., additional, Kim, Jong Hyun, additional, Kim, Louis J., additional, Kim, Paul K., additional, Kim, Thomas Aquinas, additional, Kim, Won, additional, King, James A.J., additional, Kitagawa, Ryan S., additional, Kitchen, Neil D., additional, Klimo, Paul, additional, Kline, David G., additional, Kobayashi, Kazutaka, additional, Kochanek, Patrick M., additional, Kondziolka, Douglas, additional, Kongkham, Paul N., additional, Koski, Tyler R., additional, Kosztowski, Thomas, additional, Krack, Paul, additional, Krauss, Joachim K., additional, Kraut, Michael A., additional, Krayenbühl, Niklaus, additional, Kretschmer, Thomas, additional, Krishnaney, Ajit, additional, Kuntz, Charles, additional, Kuo, Jeffrey V., additional, Kwon, Brian K., additional, Laack, Nadia N. Issa, additional, Lad, Shivanand P., additional, Ladha, Alim M., additional, Ladouceur, Amos K., additional, Lam, Arthur M., additional, Lang, Frederick F., additional, Lanzino, Giuseppe, additional, Lavine, Sean D., additional, Laws, Edward R., additional, Lawton, Michael T., additional, Laxton, Adrian W., additional, Le, Tuong H., additional, LeBas, Jean François, additional, Lebed, Brett D., additional, Lebow, Richard L., additional, Lee, Amy, additional, Lee, Ian, additional, Lee, Seon-Kyu, additional, Lehmann, Emily, additional, Leiphart, James W., additional, Lekovic, Gregory P., additional, Lenz, Frederick A., additional, Leonard, Jeffrey R., additional, LeRoux, Peter D., additional, Lévêque, Marc, additional, Levi, Allan D., additional, Levy, Elad I., additional, Liau, Linda M., additional, Liauw, Jason, additional, Lichtenbaum, Roger, additional, Lichtor, Terry, additional, Limbrick, David D., additional, Lingsma, Hester, additional, Link, Michael J., additional, Linskey, Mark E., additional, Litt, Brian, additional, Litvack, Zachary N., additional, Liu, James K.C., additional, Liu, Kenneth C., additional, Loeffler, Jay S., additional, Loftus, Christopher M., additional, Lonser, Russell R., additional, Louvi, Angeliki, additional, Lozano, Andres M., additional, Lu, Daniel C., additional, Lukas, Rimas V., additional, Lunsford, L. Dade, additional, Luther, Neal, additional, Lylyk, Pedro, additional, Maas, Andrew I.R., additional, Macdonald, R. Loch, additional, Machado, Andre, additional, Macias, Raul, additional, Maciunas, Robert J., additional, Maddux, Brian N., additional, Magistretti, Pierre, additional, Malessy, Martijn J.A., additional, Malhotra, Neil R., additional, Malone, Donald A., additional, Mamelak, Adam N., additional, Mandigo, Christopher E., additional, Mangano, Francesco T., additional, Maniker, Allen H., additional, Manley, Geoffrey T., additional, Marchac, Daniel, additional, Marmarou, Anthony, additional, Maroon, Joseph C., additional, Marshall, Lawrence F., additional, Martin, Neil A., additional, Martin, Timothy J., additional, Mason, Alexander M., additional, Mathews, Marlon S., additional, Mayberg, Helen S., additional, McAllister, James P., additional, McComb, J. Gordon, additional, McCormick, Paul C., additional, McCutcheon, Ian E., additional, McDermott, Michael W., additional, McDougall, Cameron G., additional, McGehee, Matthew, additional, McIntyre, Cameron C., additional, McKhann, Guy M., additional, McKisic, M. Sean, additional, Meaney, David F., additional, Mehta, Minesh P., additional, Mehta, Vivek, additional, Melega, William P., additional, Menezes, Arnold H., additional, Mertens, Patrick, additional, Meyer, Fredric B., additional, Meyer, Scott A., additional, Meyers, Philip M., additional, Michaelides, Costas, additional, Michaud, Karine, additional, Midha, Rajiv, additional, Miele, Vincent J., additional, Miller, Jonathan, additional, Miller, Matthew L., additional, Miller, Neil R., additional, Mitrofanis, John, additional, Miyashiro, Kevin Y., additional, Mocco, J., additional, Modic, Michael T., additional, Moftakhar, Parham, additional, Mohan, Avinash, additional, Monteith, Stephen J., additional, Morcos, Jacques J., additional, Morgan, Michael, additional, Morris, David E., additional, Moss, S. David, additional, Muizelaar, J. Paul, additional, Mukhida, Karim, additional, Mummaneni, Praveen V., additional, Murad, Gregory J.A., additional, Muraszko, Karin, additional, Mussi, Antônio C.M., additional, Najm, Imad, additional, Nakaji, Peter, additional, Narayanan, Sandra, additional, Newell, David W., additional, Nicholas, M. Kelly, additional, Niimi, Yasunari, additional, Nimjee, Shahid M., additional, Niranjan, Ajay, additional, North, Richard B., additional, Novotny, Josef, additional, Nurmikko, Turo, additional, Nutt, Samuel E., additional, Oakes, W. Jerry, additional, Obeso, José A., additional, Ogden, Alfred T., additional, Ogieglo, Lissa, additional, Ogilvy, Christopher S., additional, Okonkwo, David O., additional, Okun, Michael S., additional, Oldfield, Edward H., additional, Olivi, Alessandro, additional, Olvey, Stephen E., additional, Omahen, David, additional, O'Neill, Brent, additional, Oskouian, Rod J., additional, Owen, Robert, additional, Özduman, Koray, additional, Ozturk, Ali Kemal, additional, Pamir, M. Necmettin, additional, Pang, Dachling, additional, Pardini, Jamie, additional, Parent, Andrew D., additional, Park, T.S., additional, Partington, Michael D., additional, Patel, Aman B., additional, Patil, Parag G., additional, Pavese, Nicola, additional, Penn, Richard D., additional, Perin, Noel I., additional, Persing, John A., additional, Petersen, Erika A., additional, Petraglia, Anthony L., additional, Piallat, Brigitte, additional, Piatt, Joseph H., additional, Pickard, John D., additional, Piepmeier, Joseph M., additional, Pilcher, Webster H., additional, Pineda, José, additional, Pinter, Joseph D., additional, Pisculli, Mary L., additional, Pittman, Thomas, additional, Pollack, Ian F., additional, Pollak, Pierre, additional, Pollock, Bruce E., additional, Ponce, Francisco A., additional, Porter, Alyx B., additional, Porter, Randall W., additional, Post, Kalmon D., additional, Powers, Alexander K., additional, Proctor, Mark R., additional, Prost, Robert W., additional, Pugh, Jeffrey, additional, Quiñones-Hinojosa, Alfredo, additional, Raffel, Corey, additional, Rajpal, Sharad, additional, Rangel-Castilla, Leonardo, additional, Rao, Ganesh, additional, Raslan, Ahmed, additional, Rasmussen, Peter A., additional, Ray, Dibyendu K., additional, Raza, Shaan M., additional, Reames, Davis L., additional, Reddy, Chandan G., additional, Redmond, Andy J., additional, Régis, Jean, additional, Reilly, Peter L., additional, Renier, Dominique, additional, Resnick, Daniel K., additional, Reynolds, Renee, additional, Rezai, Ali R., additional, Rhines, Laurence D., additional, Rhoton, Albert L., additional, Ribalta, Teresa, additional, Richardson, R. Mark, additional, Rigamonti, Daniele, additional, Riggins, Gregory J., additional, Riva-Cambrin, Jay, additional, Rizzo, Paolo, additional, Roberts, David W., additional, Robertson, Claudia, additional, Robinson, Lawrence, additional, Robinson, Shenandoah, additional, Roche, Pierre-Hugues, additional, Rockoff, Mark A., additional, Rodts, Gerald E., additional, Romanelli, Pantaleo, additional, Rosenblum, Mark L., additional, Rosenow, Joshua M., additional, Rosner, Michael K., additional, Rovner, Eric S., additional, Runge-Samuelson, Christina L., additional, Russell, Stephen M., additional, Rutka, James T., additional, Sagher, Oren, additional, St. Clair, Eric G., additional, Samii, Madjid, additional, Sampath, Prakash, additional, Samudrala, Srinath, additional, Sanai, Nader, additional, Sanford, Robert A., additional, Santiago, Paul, additional, Santiago-Sim, Teresa, additional, Sarnat, Harvey B., additional, Sawaya, Raymond, additional, Scheld, W. Michael, additional, Shirzadi, Wouter I., additional, Schiff, Nicholas D., additional, Schirmer, Clemens M., additional, Schlesinger, David, additional, Schmidt, Meic H., additional, Schouten, Joost W., additional, Schramm, Johannes, additional, Schuler, Thomas C., additional, Schuster, James M., additional, Schwartz, Theodore H., additional, Schwartzbaum, Judith A., additional, Schweder, Patrick M., additional, Scott, R. Michael, additional, Seigneuret, Eric, additional, Selden, Nathan R., additional, Selman, Warren R., additional, Shaffrey, Christopher I., additional, Shah, Manish N., additional, Shahlaie, Kiarash, additional, Shapiro, William R., additional, Sharma, Deepak, additional, Sheehan, Jason P., additional, Sheehan, Jonas M., additional, Sherma, Arun K., additional, Shiflett, James M., additional, Shih, Helen A., additional, Shils, Jay L., additional, Shin, Alexander Y., additional, Shirzadi, Ali, additional, Siddiqui, Adnan H., additional, Sindou, Marc, additional, Slavin, Konstantin V., additional, Smith, Edward R., additional, Smith, Justin S., additional, Smith, Yoland, additional, Smyth, Matthew D., additional, Sneed, Penny K., additional, Snyder, Brian J., additional, Snyder, Kenneth V., additional, Solomon, Robert A., additional, Sonntag, Volker K.H., additional, Sørensen, Leif, additional, Soriano, Sulpicio G., additional, Souweidane, Mark M., additional, Spears, Julian, additional, Spencer, David, additional, Spencer, Dennis D., additional, Spetzler, Robert F., additional, Spinner, Robert J., additional, Stacey, Brett R., additional, Stacey, William C., additional, Starke, Robert M., additional, Starr, Philip A., additional, Steinberg, Gary K., additional, Stephens, Frederick L., additional, Stern, Barney J., additional, Stevenson, Charles B., additional, Stiner, Eric, additional, Stone, Scellig, additional, Stroud, Nicole L., additional, Stuart, Robert Morgan, additional, Subach, Brian R., additional, Sugrue, Patrick A., additional, Suki, Dima, additional, Sulaiman, Wale A.R., additional, Surdell, Daniel L., additional, Sutherling, William W., additional, Sutton, Leslie N., additional, Syed, Omar N., additional, Tagliati, Michele, additional, Takagi, Yasushi, additional, Tamargo, Rafael J., additional, Tan, Caroline C., additional, Tandon, Nitin, additional, Tatagiba, Marcos, additional, Taylor, Michael D., additional, Telian, Steven A., additional, Teo, Charles, additional, Tessier, Jeffrey M., additional, Than, Khoi D., additional, Thapar, Kamal, additional, Theodore, Nicholas, additional, Thompson, B. Gregory, additional, Tiel,, Robert, additional, Tihan, Tarik, additional, Tilton, Ann, additional, Timmons, Shelly D., additional, Toledo, Maria, additional, Tomita, Tadanori, additional, Tomycz, Nestor D., additional, Torres, Napoleon, additional, Toussaint, Charles P., additional, Trapp, Bruce D., additional, Traynelis, Vincent C., additional, Tubbs, R. Shane, additional, Tumialán, Luis M., additional, Tunkel, Allan R., additional, Umemura, Atsushi, additional, Vaccaro, Alexander R., additional, van Besien, Koen, additional, Vitek, Jerrold L., additional, Vives, Kenneth P., additional, Vogel, Timothy W., additional, Vogelbaum, Michael A., additional, Vollmer, Dennis G., additional, Von Allmen, Gretchen K., additional, von Eckardstein, Kajetan L., additional, Wackym, P. Ashley, additional, Wainwright, Mark, additional, Waldau, Ben, additional, Walker, Marion L., additional, Wallace, M. Christopher, additional, Walsh, Brian, additional, Wang, Huan, additional, Wang, Michael Y., additional, Wang, Vincent Y., additional, Warnick, Ronald E., additional, Webb, Sharon, additional, Weigel, Ralf, additional, Weil, Robert J., additional, Weingart, Jon D., additional, Weir, Bryce, additional, Weiss, Martin, additional, Weiss, Nirit, additional, Welch, William C., additional, Wellons, John C., additional, Wen, Hung Tzu, additional, Wess, Christian, additional, West, G. Alexander, additional, Wetjen, Nicholas M., additional, Whitmore, Robert G., additional, Whitworth, Louis A., additional, Wichmann, Thomas, additional, Wiemels, Joseph L., additional, Wijdicks, Eelco F.M., additional, Wilberger, Adam C., additional, Wilberger, Jack, additional, Wildrick, David M., additional, Wilson, Jason, additional, Winfree, Christopher J., additional, Winn, H. Richard, additional, Wolfla, Christopher, additional, Wong, Eric T., additional, Wormald, Peter J., additional, Wrensch, Margaret, additional, Wright, Neill M., additional, Wright, Zachary, additional, Yam, David, additional, Yamada, Shinya, additional, Yamada, Yoshiya, additional, Yang, Isaac, additional, Yang, Victor X.D., additional, Yao, Tom, additional, Yen, Chun-Po, additional, Yeoh, H. Kwang, additional, Yonekawa, Yasuhiro, additional, Yoo, Alice, additional, Yousem, David M., additional, Yuen, Eric C., additional, Zabramski, Joseph M., additional, Zacest, Andrew C., additional, Zacko, J. Christopher, additional, Zada, Gabriel, additional, Zafonte, Ross, additional, Zager, Eric L., additional, Zaidi, Hasan A., additional, Zarzour, Hekmat, additional, Zerris, Vasilios A., additional, Zivin, Justin A., additional, Zovickian, John G., additional, Zubkov, Alexander Y., additional, and Zwienenberg-Lee, Marike, additional

Published
2011
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27. What is OSAM?

Author

Adib , Sasan Darius, Hauser, Till-Karsten, Engel , Doortje C., Tatagiba, Marcos, Skardelly, Marco, and Fingerle-Ramina, Kristofer

Subjects
ddc: 610, cardiovascular system, 610 Medical sciences, Medicine
Abstract

Objective: Over-shunting associated myelopathy (OSAM) is a very rare complication of ventricular shunt therapy, and only 11 previous cases have been reported in the literature. We report the successful surgical management of a case of OSAM in a patient with bilateral jugular vein occlusion and congenital[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Published
2018
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28. Longitudinal Assessment of Rotation Angles after Implantation of Directional Deep Brain Stimulation Leads.

Author

Lange, Florian, Steigerwald, Frank, Engel, Doortje, Malzacher, Tobias, Neun, Tilmann, Fricke, Patrick, Volkmann, Jens, Matthies, Cordula, and Capetian, Philipp

Abstract

Purpose: The risk/benefit-ratio of deep brain stimulation (DBS) depends on focusing the electrical field onto the target volume, excluding side-effect eliciting structures. Directional leads limiting radial current diffusion can target stimulation but add a spatial degree of freedom that requires control to align multimodal imaging datasets and for anatomical interpretation of stimulation. Unpredictable postoperative lead rotations have been reported. The extent and timing of rotation from the surgically intended alignment remain uncertain, as does the time point at which directional stimulation can be safely initiated without risking unexpected shifts in stimulation volume. We present a retrospective analysis of clinically indicated, repeated neuroimaging controls postimplantation in patients with directional DBS systems, which allow estimation of the amount and timing of postoperative lead rotation. Methods: Data from 67 patients with directional leads and multiple cranial computer tomographies (CCT) and/or rotation fluoroscopies at different postoperative time points were included. Rotation angles were detected based on CCT artifacts (n = 56) or direct visualization of lead segments on rotation fluoroscopies (n = 52). Cross-validation of both methods was conducted in patients who received both imaging modalities (n = 51). Results: Rotation angles deviated significantly (∼30°) from their intended 0° anterior/posterior orientation. Rotation was firmly established within the first postoperative day, with no additional torque in subsequent scans. The two methods highly correlated (right hemisphere: R2 = 0.94, left hemisphere: R2 = 0.91). Conclusion: Both methods for measuring rotation angles led to comparable results and can be used interchangeably. Directional stimulation settings can safely be initiated after the first postoperative day, without risking subsequent lead rotation-related anatomical shifts. [ABSTRACT FROM AUTHOR]

Published
2021
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29. Secondary deterioration of idiopathic normal pressure hydrocephalus: natural course or treatment failure?

Author

Engel, Doortje, Franke, Lara, Adib, Sasan, and Schuhmann, Martin

Subjects
ddc: 610, macromolecular substances, 610 Medical sciences, Medicine
Abstract

Objective: Idiopathic normal pressure hydrocephalus (iNPH) has a naturally deteriorating course over time. A secondary deterioration during VP-Shunt (VPS) treatment is due to either natural deterioration of disease, insufficient VPS function or development of concomitant disease i.e. Alzheimer’s[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Published
2017
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32. Trigeminal Neuralgia Type 1: Earlier Microvascular Decompression is Associated with Improved Outcome

Author

Engel, Doortje C, Fournier, Jean Yves, Yetimoglu, Cem, Haile, Sarah R; https://orcid.org/0000-0002-4704-6570, Engel, Doortje C, Fournier, Jean Yves, Yetimoglu, Cem, and Haile, Sarah R; https://orcid.org/0000-0002-4704-6570

Abstract

Background: Medication therapy is commonly accepted as the initial treatment of trigeminal neuralgia (TN). Microvascular decompression (MVD) is the surgical treatment with the highest efficacy, but is considered as last tier therapy for patients with medication refractory pain or for those with unbearable side effects. The aim of this study was to investigate the association of symptom duration on outcome. Methods: A retrospective study was conducted from 2001 through 2012. Patients were categorized according to Burchiel’s “Classification scheme for facial pains commonly encountered in neurosurgical practice”. Demographical, disease and treatment data as well as surgical data including complications and outcome were recorded and analyzed. Results: In total, 65 patients were included. Distribution of diagnoses was as follows: TN type 1 (>50% episodic pain) n=54, TN type 2 (>50% constant pain) n=4, neuropathic TN n=1, symptomatic TN due to multiple sclerosis n=3, post herpetic n=2. Onset of disease to surgery was on average 7 years (<1-21 years). Shorter time from disease onset to surgery had a statistically significant association with a pain-free outcome in only TN type 1 patients (6 vs. 13 years, p=0.01). Overall success rate in TN1 was 88.9%. Overall mortality and morbidity rate were 3%. Overall complication rate was 13.5%. Conclusion: Earlier MVD was significantly associated with better outcome. Patients should be informed about the option of MVD at an early stage of disease.

Published
2018

33. Preoperative pathological silent periods correlate with the size of the concomitant syrinx in intramedullary tumors

Author

Rexer, Elisabeth, Engel, Doortje C., Ebner, Florian, Liebsch, Marina, and Tatagiba, Marcos

Subjects
fluids and secretions, ddc: 610, fungi, education, 610 Medical sciences, Medicine, equipment and supplies, intramedullary tumor, electrophysiology, silent periods
Abstract

Objective: Intramedullary ependymomas are a challenge due to their eloquent location and sometimes invasive growth pattern. Silent periods (SPs) are a method of evaluation of the spinothalamic tract. SP are used in syringomyelia diagnostics. Less is known about the role of SPs in intramedullary tumors.[for full text, please go to the a.m. URL], 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Published
2016

34. The elderly patient improves after surgery for intraspinal meningioma

Author

Engel, Doortje C., Gawellek, Lena, Peraio, Simone, Tatagiba, Marcos, and Ebner, Florian

Subjects
ddc: 610, otorhinolaryngologic diseases, outcome, 610 Medical sciences, Medicine, neoplasms, elderly, humanities, spinal meningioma, nervous system diseases
Abstract

Objective: Although meningiomas are most common in people aged between 40 and 70. The custom of operating elderly for benign tumors has increased in the past decade, as humans become older in general. Several studies have investigated complications and outcome in elderly with intracranial meningiomas.[for full text, please go to the a.m. URL], 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Published
2016

36. Traumatic brain injury: diversity of its training within Europe

Author

Engel, Doortje

Subjects
training, ddc: 610, traumatic brain injury, 610 Medical sciences, Medicine, European
Abstract

Objective: It is common knowledge that adherence to medical guidelines differs greatly between countries and hospitals or even within departments. In line with this is the diversity of training programs of neurosurgical residents throughout the world. Traumatic brain injury (TBI) is one the most common[for full text, please go to the a.m. URL], 66. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Published
2015
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37. Three versus seven days to return-to-work after mild traumatic brain injury: a randomised parallel-group trial with neuropsychological assessment

Author

Studerus-Germann, Aline M, Engel, Doortje C, Stienen, Martin N, von Ow, Dieter, Hildebrandt, Gerhard, Gautschi, Oliver P, Studerus-Germann, Aline M, Engel, Doortje C, Stienen, Martin N, von Ow, Dieter, Hildebrandt, Gerhard, and Gautschi, Oliver P

Abstract

Although most patients with a mild traumatic brain injury (mTBI) recover within days to weeks, some experience persistent physical, cognitive and emotional symptoms, often described as postconcussion syndrome (PCS). The optimal recovery time including return-to-work (RTW) after mTBI is unclear. In this single-centre parallel-group trial, patients assigned three days (3D-group) or seven days (7D-group) sick leave were compared with a comprehensive neuropsychological test battery including the Post Concussion Symptom Scale (PCSS) within one week, after three and twelve months post-injury. The influence of the effective time until RTW on postconcussional symptoms and cognitive performance was analyzed. The 3D-group rated significantly higher mean scores in some PCSS symptoms, tended to fulfil diagnosis criteria of PCS more often and showed better cognitive performance in several neuropsychological test scores than the 7D-group at all three time-points of follow-up. Overall, patients returned to work 11.35 days post injury, thus distinctly above both recommended sick leaves. There was a trend for longer sick leave in patients randomized into the 3D-group. Further analyses revealed that the group with an absolute RTW within one week showed lower symptom severity in fatigue at three and twelve months, less PCS and faster performance in fine motor speed at twelve months than the group with an absolute RTW after one week. Our data underline the heterogeneity of mTBI and shows that acute and sub-acute symptoms are not prognostic factors for neuropsychological outcome at one year. Later ability to work seems to be prognostic for long-term occurrence of PCS.

Published
2017

38. Experimental model for training of endoscopic transsphenoidal pituitary surgery

Author

Engel, Doortje, Tasman, Abel-Jan, Schmid, Raphael, Schindel, Ralf, and Fournier, Jean-Yves

Subjects
pituitary surgery, training, ddc: 610, education, 610 Medical sciences, Medicine, endoscopy
Abstract

Objective: Transsphenoidal endoscopic surgery has gained popularity in the last 2 decades and is becoming the standard technique for resection of pituitary adenomas. In contrast to their ENT colleagues, neurosurgical residents have practically no endoscopic experience when they reach the training stadium[for full text, please go to the a.m. URL], 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Published
2014

44. Standardizing Data Collection in Traumatic Brain Injury

Author

WALTER REED ARMY INST OF RESEARCH WASHINGTON DC, Maas, Andrew I., Harrison-Felix, Cynthia L., Menon, David, Adelson, P. D., Balkin, Tom, Bullock, Ross, Engel, Doortje C., Gordon, Wayne, Langlois-Orman, Jean, Lew, Henry L., WALTER REED ARMY INST OF RESEARCH WASHINGTON DC, Maas, Andrew I., Harrison-Felix, Cynthia L., Menon, David, Adelson, P. D., Balkin, Tom, Bullock, Ross, Engel, Doortje C., Gordon, Wayne, Langlois-Orman, Jean, and Lew, Henry L.

Abstract

Collaboration among investigators, centers, countries and disciplines is essential to advancing the care for traumatic brain injury (TBI). It is then important that we "speak the same language". Great variability, however exists in data collection and coding of variables in TBI studies, confounding comparisons between and analysis across different studies. Randomized controlled trials can never address the many uncertainties around treatment approaches in TBI. Pooling data from different clinical studies and high-quality observational studies combined with Comparative Effectiveness Research may provide excellent alternatives in a cost-efficient way. Standardization of data collection and coding is essential to this purpose. Common Data Elements are presented for demographics and clinical variables applicable across the broad spectrum of TBI. Most recommendations represent a consensus, derived from clinical practice. Some recommendations concern novel approaches, for example towards assessing the intensity of therapy in severely injured patients. Up to three levels of detail for coding data elements were developed: basic, intermediate, and advanced, with the greatest level of detail in the advanced version. More detailed codings can be collapsed into the basic version. Templates were produced to summarize coding formats explanation of choices and recommendations for procedures. Endorsement of the recommendations has been obtained from many authoritative organisations. The development of Common Data Elements for TBI should be viewed as a continuing process: As more experience is gained, refinement and amendments will be required. This proposed process of standardization will facilitate Comparative Effectiveness Research and encourage high-quality meta-analysis of individual patient data., Pub. in Journal of Neurotrauma, p1-45, 2010.

Published
2010

47. Inhalation of Nitric Oxide Prevents Ischemic Brain Damage in Experimental Stroke by Selective Dilatation of Collateral Arterioles

Author

Terpolilli, Nicole A., primary, Kim, Seong-Woong, additional, Thal, Serge C., additional, Kataoka, Hiroharu, additional, Zeisig, Vilia, additional, Nitzsche, Bjoern, additional, Klaesner, Benjamin, additional, Zhu, Changlian, additional, Schwarzmaier, Susanne, additional, Meissner, Lilja, additional, Mamrak, Uta, additional, Engel, Doortje C., additional, Drzezga, Alexander, additional, Patel, Rakesh P., additional, Blomgren, Klas, additional, Barthel, Henryk, additional, Boltze, Johannes, additional, Kuebler, Wolfgang M., additional, and Plesnila, Nikolaus, additional

Published
2012
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48. Standardizing Data Collection in Traumatic Brain Injury

Author

Maas, Andrew I.R., primary, Harrison-Felix, Cynthia L., additional, Menon, David, additional, Adelson, P. David, additional, Balkin, Tom, additional, Bullock, Ross, additional, Engel, Doortje C., additional, Gordon, Wayne, additional, Langlois-Orman, Jean, additional, Lew, Henry L., additional, Robertson, Claudia, additional, Temkin, Nancy, additional, Valadka, Alex, additional, Verfaellie, Mieke, additional, Wainwright, Mark, additional, Wright, David W., additional, and Schwab, Karen, additional

Published
2011
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