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158 results on '"Engbersen, J.F.J."'

2. Responsive Layer-by-Layer Films

Author

Hujaya, Sry Dewi, Wohl, Benjamin M., Engbersen, J.F.J., Paulusse, J.M.J., Biomaterials Science and Technology, Advanced Organ bioengineering and Therapeutics, TechMed Centre, MESA+ Institute, and Biomolecular Nanotechnology

Subjects
NLA
Abstract

Layer-by-layer (LbL) assembly is the process of building functional multilayered thin films. Owing to its highly modular and versatile nature, it has been used to coat a wide variety of different surfaces, including inorganic substrates, membranes, implants, nanoparticles and even living cells. It provides ways to induce responsiveness through both the chemically engineered macromolecular components, and the way the multilayers are built up. For example, assembly degradability can be adjusted by using degradable polymers or crosslinkers, while physical properties can be altered through the use of additives, or by the assembly method. This chapter is dedicated to LbL fabrication-specific responsiveness, and to recent developments in multilayers composed of specifically tailored polymers. It further focuses on chemically and biologically responsive LbL systems, with main applications in the biomedical field. The introduction covers general aspects of LbL assembly and physicochemical aspects of the assemblies. The second part describes physicochemical aspects in more detail with examples on how variation in deposition conditions, e.g. pH and ionic strength, as well as specific additives, induce responsiveness to the resulting multilayers. It also highlights several reports on compartmentalized multilayered coating fabrication for tunable disassembly or release of incorporated materials. The third part describes multilayers fabricated with chemically tailored biomaterials for different chemical and biological responsiveness. More specifically, multilayer disassembly can be triggered by the inherent responsiveness of one of the multilayer components, through incorporation of labile bonds that respond to specific external triggers, or through disruption of the interlayer interaction between two or more multilayer components.

Published
2022

8. Molecular recognition by self-assembled monolayers of cavitand receptors

Author

Schierbaum, K.D., Weiss, T., Thoden van Velzen, E.U., Engbersen, J.F.J., Reinhoudt, D.N., and Gopel, W.

Subjects
Molecular biology -- Research, Monomolecular films -- Research, Science and technology, Research
Abstract

It is shown by angle-resolved x-ray photoelectron spectroscopy that cavitands derived from resorcin[4]arenes provided with four dialkylsulfide chains form stable monolayers on gold surfaces that are well organized by self-assembly. The cavitand headgroups at the surface of the resorcin[4]arene monolayer act as molecular recognition sites for small organic molecules with remarkable selectivity for perchloroethylene ([C.sub.2][Cl.sub.4]). Comparati thermal desoption experiments indicate binding sites with high interaction energies of [C.sub.2][Cl.sub.4] at the surface of the resorcin[4]arene monolayers. Fast and reversible 'host-gue nanogram range) with a quartz microbalance oscillator provided with gold electrodes coated by resorcin[4]arene monolayers., Molecular recognition is an essential feature of many biological processes in living cells, for example, during the specific 'host-guest' coupling of compounds at receptors in lipid membranes. During the last [...]

Published
1994

10. Synthesis and Binding-Properties of Novel Cyclodextrin Dimers

Author

Venema, F., Baselier, C.M., Dienst, E. van, Ruel, B.H.M., Feiters, M.C., Engbersen, J.F.J., Reinhoudt, D.N., and Nolte, R.J.M.

Subjects
GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Contains fulltext : 10579.pdf (Publisher’s version ) (Open Access)

Published
1994

11. Bioreducible poly(amidoamine)s with charge-reversel properties for intracellular protein delivery

Author

Coué, G.M.J.P.C., Engbersen, Johannes F.J., Hennink, W.E., Engbersen, J.F.J., and Faculty of Science and Technology

Subjects
chemistry.chemical_classification, IR-80273, Drug Carriers, Endosome, Amidoamine, Pharmaceutical Science, Proteins, Charge (physics), Polymer, Poly(amidoamine), chemistry.chemical_compound, Polymer degradation, chemistry, Polymer chemistry, Biophysics, Polyamines, Particle Size, Pendant group, Drug carrier, METIS-274351, METIS-274375
Abstract

An effective intracellular protein delivery system was developed using bioreducible disulfide-containing poly(amidoamine)s with negatively charged citraconic side groups that can give charge-reversal upon pH decrease. These water-soluble and linear polymers efficiently self-assemble with proteins into nanocomplexes by charge attraction. Intracellular-mimicking protein release from the particles is triggered by the reduction of polymer disulfide linkages, causing polymer degradation, and inversion of protein-polymer interaction at endosomal pH due to the charge-reversal of the citraconic side group.

Published
2010

18. Kinome analysis of stem cells

Author

Koopman, H.F.J.M., Scholma, Jetse, Joore, J.Th., Kanger, J.S., Engbersen, J.F.J., Post, J.N., and Kruijer, W.

Subjects
METIS-255686
Published
2008

36. Novel poly(amido amine)s with bioreducible disulfide linkages in their diamino-units: structure effects and in vitro gene transfer properties

Author

Advanced drug delivery systems/drug targeting, Dep Farmaceutische wetenschappen, Piest, M., Lin, C., Mateos-Timoneda, M.A., Lok, M.C., Hennink, W.E., Feijen, J., Engbersen, J.F.J., Advanced drug delivery systems/drug targeting, Dep Farmaceutische wetenschappen, Piest, M., Lin, C., Mateos-Timoneda, M.A., Lok, M.C., Hennink, W.E., Feijen, J., and Engbersen, J.F.J.

Published
2008

37. Bioreducible poly(amido amine)s with oligoamine side chains: Synthesis, characterization, and structural effects on gene delivery

Author

Advanced drug delivery systems/drug targeting, Dep Farmaceutische wetenschappen, Lin, C., Blaauboer, C.J., Timoneda, M.M., Lok, M.C., van Steenbergen, M.J., Hennink, W.E., Zhong, Z., Feijen, J., Engbersen, J.F.J., Advanced drug delivery systems/drug targeting, Dep Farmaceutische wetenschappen, Lin, C., Blaauboer, C.J., Timoneda, M.M., Lok, M.C., van Steenbergen, M.J., Hennink, W.E., Zhong, Z., Feijen, J., and Engbersen, J.F.J.

Published
2008

41. Linear poly(amido amine)s with secondary and tertiary amino groups and variable amounts of disulfide linkages: synthesis and in vitro gene transfer properties

Author

Advanced drug delivery systems/drug targeting, Dep Farmaceutische wetenschappen, Lin, C., Zhong, M.C., Jiang, X., Hennink, W.E., Feijen, J., Engbersen, J.F.J., Advanced drug delivery systems/drug targeting, Dep Farmaceutische wetenschappen, Lin, C., Zhong, M.C., Jiang, X., Hennink, W.E., Feijen, J., and Engbersen, J.F.J.

Published
2006

42. Polysilylenes with ethynylphenyl-substituents

Author

Frey, H., Schulenburg, E.-J., Möller, M., Noorlander-Bunt, H., Engbersen, J.F.J., Reinhoudt, D.N., Faculty of Science and Technology, and Materials Science and Technology of Polymers

Abstract

Ethynylphenyl-methyldichlorosilane (EPDMS) has been prepared as a new monomer for the synthesis of polysilylenes with triple bonds attached to the catenated Si chain. A series of copolymers with methylphenyldichlorosilane (MPDS) as well as the homopolymer, PEPMS, have been synthesized. The content of ethynylphenyl substituents was quantitatively analyzed by FTIR spectroscopy. The optical properties of the new polymers were studied with respect to potential - interaction. No significant bathochromic shift of the UV-absorption maximum could be detected. Unexpectedly, increasing content of incorporated EPMS units led to a decrease of the (-*) absorption. The ethynylphenyl-substituted polysilylenes exhibited strong, temperature-dependent fluorescence in solution as well as in films.

Published
1995

43. A Double Chemfet Flow Cell System for Detection of Heavy Metal Ions and Integration in µTAS

Author

Engbersen, J.F.J., Cobben, P.L.H.M., Lugtenberg, R.J.W., Reinhoudt, D.N., van den Berg, A., Bergveld, P., and Faculty of Science and Technology

Subjects
Aqueous solution, Materials science, Supporting electrolyte, Metal ions in aqueous solution, Analytical chemistry, Differential signal, Reference electrode, Hydroxyethyl methacrylate, Ion, Covalent attachment, Metal, visual_art, Miniaturization, visual_art.visual_art_medium, Total analysis system, Flow cells, Crown ether
Abstract

A new type of flow cell has been developed for detection of heavy metal ions in aqueous solutions, based on the flow injection method. The cell contains two chemically modified field effect transistors (CHEMFETs) of which one is selective for the supporting electrolyte ion (in this case a 0.1 M potassium ion solution) and the other is selective for the heavy metal ion to be detected (Cd2+, Pb2+). The differential signal of the reference electrode CHEMFET and the heavy metal ion CHEMFET in the flow cell system which has been presently developed will be evaluated for miniaturization and further integration in a micro total analysis system.

Published
1995
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44. Chemical microsensors

Author

Engbersen, J.F.J., Olthuis, W., and Bos, M.

Subjects
METIS-116936
Published
1995

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