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2. The translational use of kisspeptin and kisspeptin receptor agonists in humans

Author

Eng, Pei Chia, Abbara, Ali, Dhillo, Waljit, and Comninos, Alexander

Abstract

Kisspeptin is a neuropeptide that is known to be a critical regulator of hypothalamic gonadotrophin releasing hormone (GnRH). Physiological studies of kisspeptin have examined the effects of different kisspeptin isoforms (Kisspeptin-10, kisspeptin-54) on GnRH release in men and women. These studies have not only produced new insights into kisspeptin physiology but also paved the way for future studies using kisspeptin as a physiologic, diagnostic and therapeutic tool in individuals with reproductive disorders. The human kisspeptin peptides, Kisspeptin-10, -13, -14, -54 are named according to their constituent amino acids. Kisspeptin-10, being smaller and easier to synthesize, offers a far more economically viable therapy compared to the longer Kisspeptin-54 peptide. However, due to Kisspeptin-10's shorter half-life, it requires repeated dosing or prolonged infusion. Kisspeptin receptor agonist (MVT-602) is a modified form of kisspeptin-10 with a longer half-life compared to native kisspeptin-54 (1.5-3.5 hrs vs 0.5 hrs). However, effects of MVT-602 in women have never been determined. By investigating the effects of MVT-602 in healthy women and women with reproductive disorders, I uncovered novel understanding of the effects of MVT-602 in women and demonstrated for the first time that the prolonged and sustained rise of gonadotrophins with MVT-602 can be used as a therapeutic tool in women with reproductive disorders. Having established the effects of MVT-602 in women, I proceeded to investigate the utility of Kisspeptin-54 to interrogate hypothalamic function in men with Congenital Hypogonadotrophic Hypogonadism (CHH). I have shown that a kisspeptin-54 test, unlike the currently used GnRH test, could offer significant clinical benefit for the accurate diagnosis and management of patients with hypogonadism. In summary, the data conceived from this thesis have important implications for the development of kisspeptin as a potential therapeutic and diagnostic tool for reproductive pathologies.

Published
2020
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4. Performance of plasma kisspeptin as a biomarker for miscarriage improves with gestational age during the first trimester

Author

Abbara, Ali, Al-Memar, Maya, Phylactou, Maria, Kyriacou, Christopher, Eng, Pei Chia, Nadir, Rans, Izzi-Engbeaya, Chioma, Clarke, Sophie A., Mills, Edouard G., Daniels, Elisabeth, Huo, Lechun, Pacuszka, Ewa, Yang, Lisa, Patel, Bijal, Tan, Tricia, Bech, Paul, Comninos, Alexander N., Fourie, Hanine, Kelsey, Tom W., Bourne, Tom, and Dhillo, Waljit S.

Published
2021
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5. Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders

Author

Abbara, Ali, Eng, Pei Chia, Phylactou, Maria, Clarke, Sophie A., Richardson, Rachel, Sykes, Charlene M., Phumsatitpong, Chayarndorn, Mills, Edouard, Modi, Manish, Izzi-Engbeaya, Chioma, Papadopoulou, Debbie, Purugganan, Kate, Jayasena, Channa N., Webber, Lisa, Salim, Rehan, Owen, Bryn, Bech, Paul, Comninos, Alexander N., McArdle, Craig A., Voliotis, Margaritis, Tsaneva-Atanasova, Krasimira, Moenter, Suzanne, Hanyaloglu, Aylin, and Dhillo, Waljit S.

Subjects
Cell receptors -- Health aspects, Female genital diseases -- Genetic aspects -- Development and progression -- Care and treatment, Health care industry
Abstract

BACKGROUND. Kisspeptin is a key regulator of hypothalamic gonadotropin-releasing hormone (GnRH) neurons and is essential for reproductive health. A specific kisspeptin receptor (KISS1R) agonist could significantly expand the potential clinical utility of therapeutics targeting the kisspeptin pathway. Herein, we investigate the effects of a KISS1R agonist, MVT-602, in healthy women and in women with reproductive disorders. METHODS. We conducted in vivo and in vitro studies to characterize the action of MVT-602 in comparison with native kisspeptin-54 (KP54). We determined the pharmacokinetic and pharmacodynamic properties of MVT-602 (doses 0.01 and 0.03 nmol/kg) versus KP54 (9.6 nmol/kg) in the follicular phase of healthy women (n = 9), and in women with polycystic ovary syndrome (PCOS; n = 6) or hypothalamic amenorrhea (HA; n = 6). Further, we investigated their effects on KISS1R-mediated inositol monophosphate ([IP.sub.1]) and [Ca.sup.2+] signaling in cell lines and on action potential firing of GnRH neurons in brain slices. RESULTS. In healthy women, the amplitude of luteinizing hormone (LH) rise was similar to that after KP54, but peaked later (21.4 vs. 4.7 hours; P = 0.0002), with correspondingly increased AUC of LH exposure (169.0 vs. 38.5 IU-h/L; P = 0.0058). LH increases following MVT-602 were similar in PCOS and healthy women, but advanced in HA (P = 0.004). In keeping with the clinical data, MVT-602 induced more potent signaling of KISS1R-mediated [IP.sub.1] accumulation and a longer duration of GnRH neuron firing than KP54 (115 vs. 55 minutes; P = 0.0012). CONCLUSION. Taken together, these clinical and mechanistic data identify MVT-602 as having considerable therapeutic potential for the treatment of female reproductive disorders. TRIAL REGISTRATION. International Standard Randomised Controlled Trial Number (ISRCTN) Registry, ISRCTN21681316. FUNDING. National Institute for Health Research and NIH., Introduction Kisspeptin is recognized to play a pivotal role in the regulation of reproductive hormone secretion following 2 landmark reports in 2003, demonstrating that decreased signaling of its G protein-coupled [...]

Published
2020
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6. Obesity-Related Hypogonadism in Women.

Author

Eng, Pei Chia, Phylactou, Maria, Qayum, Ambreen, Woods, Casper, Lee, Hayoung, Aziz, Sara, Moore, Benedict, Miras, Alexander D, Comninos, Alexander N, Tan, Tricia, Franks, Steve, Dhillo, Waljit S, and Abbara, Ali

Abstract

Obesity-related hypogonadotropic hypogonadism is a well-characterized condition in men (termed male obesity-related secondary hypogonadism; MOSH); however, an equivalent condition has not been as clearly described in women. The prevalence of polycystic ovary syndrome (PCOS) is known to increase with obesity, but PCOS is more typically characterized by increased gonadotropin-releasing hormone (GnRH) (and by proxy luteinizing hormone; LH) pulsatility, rather than by the reduced gonadotropin levels observed in MOSH. Notably, LH levels and LH pulse amplitude are reduced with obesity, both in women with and without PCOS, suggesting that an obesity-related secondary hypogonadism may also exist in women akin to MOSH in men. Herein, we examine the evidence for the existence of a putative non-PCOS "female obesity-related secondary hypogonadism" (FOSH). We précis possible underlying mechanisms for the occurrence of hypogonadism in this context and consider how such mechanisms differ from MOSH in men, and from PCOS in women without obesity. In this review, we consider relevant etiological factors that are altered in obesity and that could impact on GnRH pulsatility to ascertain whether they could contribute to obesity-related secondary hypogonadism including: anti-Müllerian hormone, androgen, insulin, fatty acid, adiponectin, and leptin. More precise phenotyping of hypogonadism in women with obesity could provide further validation for non-PCOS FOSH and preface the ability to define/investigate such a condition. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Obesity-Related Hypogonadism in Women

Author

Eng, Pei Chia, primary, Phylactou, Maria, additional, Qayum, Ambreen, additional, Woods, Casper, additional, Lee, Hayoung, additional, Aziz, Sara, additional, Moore, Benedict, additional, Miras, Alexander D, additional, Comninos, Alexander N, additional, Tan, Tricia, additional, Franks, Steve, additional, Dhillo, Waljit S, additional, and Abbara, Ali, additional

Published
2023
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10. Endocrine responses to triptorelin in healthy women, women with Polycystic Ovary Syndrome and Hypothalamic Amenorrhea

Author

Abbara, Ali, primary, Phylactou, Maria, additional, Eng, Pei Chia, additional, Clarke, Sophie A, additional, Pham, Toan D, additional, M H, Tuong, additional, Ng, Kah Yan, additional, Mills, Edouard G, additional, Purugganan, Kate, additional, Hunjan, Tia, additional, Salim, Rehan, additional, Comninos, Alexander N, additional, Vuong, Lan N, additional, and Dhillo, Waljit S, additional

Published
2023
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12. Insulin-like peptide 3 (INSL3) in congenital hypogonadotrophic hypogonadism (CHH) in boys with delayed puberty and adult men

Author

Abbara, Ali, primary, Koysombat, Kanyada, additional, Phylactou, Maria, additional, Eng, Pei Chia, additional, Clarke, Sophie, additional, Comninos, Alexander N., additional, Yang, Lisa, additional, Izzi-Engbeaya, Chioma, additional, Hanassab, Simon, additional, Smith, Neil, additional, Jayasena, Channa N., additional, Xu, Cheng, additional, Quinton, Richard, additional, Pitteloud, Nelly, additional, Binder, Gerhard, additional, Anand-Ivell, Ravinder, additional, Ivell, Richard, additional, and Dhillo, Waljit S., additional

Published
2022
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13. RF01 | PMON43 Melanocortin-4 Receptor Agonism Enhances Sexual Brain Processing in Women with Hypoactive Sexual Desire Disorder

Author

Thurston, Layla, primary, Hunjan, Tia, additional, Mills, Edouard, additional, Wall, Matthew, additional, Ertl, Natalie, additional, Phylactou, Maria, additional, Muzi, Beatrice, additional, Patel, Bijal, additional, Alexander, Emma, additional, Suladze, Sofiya, additional, Modi, Manish, additional, Eng, Pei Chia, additional, Bassett, Paul, additional, Abbara, Ali, additional, Goldmeier, David, additional, Comninos, Alexander, additional, and Dhillo, Waljit, additional

Published
2022
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19. A Novel Somatic Mutation Implicates ATP6V0D1 in Proinsulin Processing.

Author

Avari, Parizad, Eng, Pei Chia, Hu, Ming, Chen, Runzhi, Popovic, Natalija, Polychronakos, Constantin, Spalding, Duncan, Rutter, Guy A, Oliver, Nick, and Wernig, Florian

Abstract

Context Prohormone convertase 1/3 (PC1/3), encoded by protein convertase subtilisin kexin type 1 (PCSK1), converts inactive prohormones into biologically active peptides. Somatic mutations of insulinomas are associated with genetic defects interfering with control of insulin secretion from pancreatic beta cells. However, somatic mutations in proinsulinomas have not been described. Objective We report a case of a proinsulinoma, with suppressed insulin and C-peptide levels. Methods A 70-year-old woman presented with a 20-year history of "blackouts." During a 72-hour fast, blood glucose level dropped to 1.9 mmol/L with suppressed plasma insulin and C-peptide levels, but proinsulin levels were raised at 37 pmol/L (<10 pmol/L). Results Imaging revealed 3 distinct DOTATATE-avid pancreatic lesions. Laparoscopic spleen-preserving distal pancreatomy was performed. In view of discordant insulin, C-peptide, and proinsulin levels, whole exome sequencing analysis was performed on the tumor. In the somatic exome of the tumor, we found mutations in PCSK expression regulators, as well as a novel truncating somatic mutation in ATP6V0D1 , a subunit of the ion pump that acidifies the β-cell compartments where the PCSKs act. Conclusion Appropriately suppressed insulin levels in the context of hypoglycemia do not always indicate the absence of a neuroendocrine islet cell tumor and proinsulin levels may be indicated to solidify the diagnosis. In the context of elevated proinsulin levels, low insulin and C-peptide levels might be explained by somatic mutations that likely implicate proinsulin processing within the tumor. Furthermore, we propose several mechanistic candidates, including ATP6V0D1. Experimental validation using cellular approaches may in future confirm pathomechanisms involved in this rare condition. [ABSTRACT FROM AUTHOR]

Published
2023
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20. The benefit of dexamethasone in patients with COVID ‐19 infection is preserved in patients with diabetes

Author

Eng, Pei Chia, primary, Distaso, Walter, additional, Durreshahwar, Hashmi, additional, Shaikhali, Yusuf, additional, Narendranathan, Divani, additional, Cassin‐Scott, Rebecca, additional, Misra, Shivani, additional, Hill, Neil E., additional, Tharakan, George, additional, Oliver, Nick S., additional, Tan, Tricia M., additional, Izzi‐Engbeaya, Chioma, additional, and Salem, Victoria, additional

Published
2022
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22. An unusual presentation of hypoglycaemia: An investigative challenge

Author

Parizad Avari, Duncan Spalding, Eng Pei Chia, Nicholas H.S. Oliver, Runzi Chen, and Florian Wernig

Subjects
Presentation, medicine.medical_specialty, business.industry, media_common.quotation_subject, Medicine, business, Intensive care medicine, media_common
Published
2021

24. Thyroid Function Before, During and After COVID-19

Author

Eu Khoo, Bernard Chong, primary, Tan, Tricia, additional, Mills, Edouard, additional, Clarke, Sophie A, additional, Patel, Bijal, additional, Modi, Manish, additional, Phylactou, Maria, additional, Eng, Pei Chia, additional, Thurston, Layla, additional, Alexander, Emma C, additional, Meeran, Karim, additional, Comninos, Alexander N, additional, Abbara, Ali, additional, and Dhillo, Waljit Singh, additional

Published
2021
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25. Kisspeptin-54 accurately identifies hypothalamic dysfunction in men with congenital hypogonadotropic hypogonadism

Author

Channa N. Jayasena, Ali Abbara, Sophie Clarke, Chioma Izzi-Engbeaya, Germaine Chia, Ravinder Anand-Ivell, Waljit S. Dhillo, Jesse Rademaker, Edouard Mills, Nelly Pittelout, Eng Pei Chia, Alexander N Comninos, Richard Quinton, Maria Phylactou, Richard Ivell, Lisa Yang, and Xu Cheng

Subjects
medicine.medical_specialty, Endocrinology, Kisspeptin, business.industry, Internal medicine, Hypothalamic dysfunction, medicine, Congenital Hypogonadotropic Hypogonadism, business
Published
2020

26. Kisspeptin as a biomarker for pregnancy complications

Author

Maria Phylactou, Rans Nadir, Tom Kelsey, Waljit S. Dhillo, Mark Sykes, Paul Bech, Ewa Pacuszka, Ali Abbara, Tom Bourne, Alexander N Comninos, Edouard Mills, Lisa Yang, H. Fourie, Sophie Clarke, Eng Pei Chia, Chioma Izzi-Engbeaya, and Maya Al-Memar

Subjects
Pregnancy, Kisspeptin, business.industry, medicine, Biomarker (medicine), medicine.disease, Bioinformatics, business
Published
2020

27. Kisspeptin-54 Accurately Identifies Hypothalamic Gonadotropin-Releasing Hormone Neuronal Dysfunction in Men with Congenital Hypogonadotropic Hypogonadism

Author

Abbara, Ali, primary, Eng, Pei Chia, additional, Phylactou, Maria, additional, Clarke, Sophie A., additional, Mills, Edouard, additional, Chia, Germaine, additional, Yang, Lisa, additional, Izzi-Engbeaya, Chioma, additional, Smith, Neil, additional, Jayasena, Channa N., additional, Comninos, Alexander N., additional, Anand-Ivell, Ravinder, additional, Rademaker, Jesse, additional, Xu, Cheng, additional, Quinton, Richard, additional, Pitteloud, Nelly, additional, and Dhillo, Waljit S., additional

Published
2020
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28. Thyroid Function Before, During, and After COVID-19

Author

Khoo, Bernard, primary, Tan, Tricia, additional, Clarke, Sophie A, additional, Mills, Edouard G, additional, Patel, Bijal, additional, Modi, Manish, additional, Phylactou, Maria, additional, Eng, Pei Chia, additional, Thurston, Layla, additional, Alexander, Emma C, additional, Meeran, Karim, additional, Comninos, Alexander N, additional, Abbara, Ali, additional, and Dhillo, Waljit S, additional

Published
2020
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29. Pharmacodynamic Response to Anti-thyroid Drugs in Graves' Hyperthyroidism

Author

Abbara, Ali, primary, Clarke, Sophie A., additional, Brewster, Rosalind, additional, Simonnard, Alexia, additional, Eng, Pei Chia, additional, Phylactou, Maria, additional, Papadopoulou, Deborah, additional, Izzi-Engbeaya, Chioma, additional, Sam, Amir H., additional, Wernig, Florian, additional, Jonauskyte, Eliza, additional, Comninos, Alexander N., additional, Meeran, Karim, additional, Kelsey, Tom W., additional, and Dhillo, Waljit S., additional

Published
2020
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31. OR20-06 Kisspeptin as a Biomarker for Pregnancy Complications

Author

Phylactou, Maria, primary, Abbara, Ali, primary, Al-Memar, Maya, primary, Eng, Pei Chia, primary, Comninos, Alexander N, primary, Izzi-Engbeaya, Chioma, primary, Clarke, Sophie A, primary, Mills, Edouard, primary, Nadir, Rans, primary, Sykes, Mark, primary, Ewa, Pacuszka, primary, Yang, Lisa, primary, Fourie, Hanine, primary, Bech, Paul, primary, Kelsey, Tom, primary, Bourne, Tom, primary, and Dhillo, Waljit Singh, primary

Published
2020
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32. Acute Effects of Glucagon on Reproductive Hormone Secretion in Healthy Men

Author

Izzi-Engbeaya, Chioma, primary, Jones, Sophie, additional, Crustna, Yoshibye, additional, Machenahalli, Pratibha C, additional, Papadopoulou, Deborah, additional, Modi, Manish, additional, Starikova, Jessica, additional, Chan, Derek, additional, Eng, Pei Chia, additional, Phylactou, Maria, additional, Ratnasabapathy, Risheka, additional, Mills, Edouard, additional, Yang, Lisa, additional, Pacuszka, Ewa, additional, Bech, Paul, additional, Minnion, James, additional, Tharakan, George, additional, Tan, Tricia, additional, Veldhuis, Johannes, additional, Abbara, Ali, additional, Comninos, Alexander N, additional, and Dhillo, Waljit S, additional

Published
2020
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34. Effects of Glucagon-like Peptide-1 on the Reproductive Axis in Healthy Men

Author

Izzi-Engbeaya, Chioma, primary, Jones, Sophie, additional, Crustna, Yoshibye, additional, Machenahalli, Pratibha C, additional, Papadopoulou, Deborah, additional, Modi, Manish, additional, Panayi, Christos, additional, Starikova, Jessica, additional, Eng, Pei Chia, additional, Phylactou, Maria, additional, Mills, Edouard, additional, Yang, Lisa, additional, Ratnasabapathy, Risheka, additional, Sykes, Mark, additional, Plumptre, Isabella, additional, Coumbe, Ben, additional, Wing, Victoria C, additional, Pacuszka, Ewa, additional, Bech, Paul, additional, Minnion, James, additional, Tharakan, George, additional, Tan, Tricia, additional, Veldhuis, Johannes, additional, Abbara, Ali, additional, Comninos, Alexander N, additional, and Dhillo, Waljit S, additional

Published
2020
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36. The effects of peptide-YY (PYY) on the reproductive axis in humans

Author

Izzi-Engbeaya, Chioma, primary, Jones, Sophie, additional, Crustna, Yoshibye, additional, Machenahalli, Pratibha, additional, Papadopoulou, Deborah, additional, Modi, Manish, additional, Panayi, Christos, additional, Starikova, Jessica, additional, Eng, Pei Chia, additional, Phylactou, Maria, additional, Mills, Edouard, additional, Yang, Lisa, additional, Ratnasabapathy, Risheka, additional, Sykes, Mark, additional, Plumptre, Isabella, additional, Minnion, James, additional, Tharakan, George, additional, Tan, Tricia, additional, Veldhuis, Johannes, additional, Abbara, Ali, additional, Comninos, Alexander, additional, and Dhillo, Waljit, additional

Published
2019
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37. Kisspeptin as a novel biomarker for pregnancy complications

Author

Phylactou, Maria, primary, Abbara, Ali, additional, Al-Memar, Maya, additional, Eng, Pei Chia, additional, Comninos, Alexander N, additional, Izzi-Engbeaya, Chioma, additional, Clarke, Sophie A, additional, Mills, Edouard, additional, Nadir, Rans, additional, Sykes, Mark, additional, Pacuszka, Ewa, additional, Yang, Lisa, additional, Fourie, Hanine, additional, Bech, Paul, additional, Kelsey, Tom W, additional, Bourne, Tom, additional, and Dhillo, Waljit S, additional

Published
2019
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38. Gonadotrophin rise following the kisspeptin analogue (MVT-602) is increased in women with hypothalamic amenorrhoea compared to healthy women

Author

Eng, Pei Chia, primary, Abbara, Ali, additional, Phylactou, Maria, additional, Clarke, Sophie A, additional, Yang, Lisa, additional, Mills, Edouard, additional, Modi, Manish, additional, Papadopoulou, Deborah, additional, Plumptre, Isabella, additional, Hunjan, Tia, additional, Purugganan, Kate, additional, Webber, Lisa, additional, Salim, Rehan, additional, Comninos, Alexander N, additional, and Dhillo, Waljit S, additional

Published
2019
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39. Kisspeptin-54 Accurately Identifies Hypothalamic Gonadotropin-Releasing Hormone Neuronal Dysfunction in Men with Congenital Hypogonadotropic Hypogonadism.

Author

Abbara, Ali, Eng, Pei Chia, Phylactou, Maria, Clarke, Sophie A., Mills, Edouard, Chia, Germaine, Yang, Lisa, Izzi-Engbeaya, Chioma, Smith, Neil, Jayasena, Channa N., Comninos, Alexander N., Anand-Ivell, Ravinder, Rademaker, Jesse, Xu, Cheng, Quinton, Richard, Pitteloud, Nelly, and Dhillo, Waljit S.

Subjects
*HYPOTHALAMIC hormones, *HYPOGONADISM, *KALLMANN syndrome, *RECEIVER operating characteristic curves, *GENETIC variation
Abstract

Background: Hypogonadotropic hypogonadism (HH) is hypogonadism due to either hypothalamic or pituitary dysfunction. While gonadotropin-releasing hormone (GnRH) can directly test pituitary function, no specific test of hypothalamic function exists. Kisspeptin-54 (KP54) is a neuropeptide that directly stimulates hypothalamic GnRH release and thus could be used to specifically interrogate hypothalamic function. Congenital HH (CHH) is typically due to variants in genes that control hypothalamic GnRH neuronal migration or function. Thus, we investigated whether KP54 could accurately identify hypothalamic dysfunction in men with CHH. Methods: Men with CHH (n = 21) and healthy eugonadal men (n = 21) received an intravenous bolus of either GnRH (100 μg) or KP54 (6.4 nmol/kg), on 2 occasions, and were monitored for 6 h after administration of each neuropeptide. Results: Maximal luteinizing hormone (LH) rise after KP54 was significantly greater in healthy men (12.5 iU/L) than in men with CHH (0.4 iU/L; p < 0.0001). KP54 more accurately differentiated CHH men from healthy men than GnRH (area under receiver operating characteristic curve KP54: 1.0, 95% CI 1.0–1.0; GnRH: 0.88, 95% CI 0.76–0.99). Indeed, all CHH men had an LH rise <2.0 iU/L following KP54, whereas all healthy men had an LH rise >4.0 iU/L. Anosmic men with CHH (i.e., Kallmann syndrome) had even lower LH rises after KP54 than did normosmic men with CHH (p = 0.017). Likewise, men identified to have pathogenic/likely pathogenic variants in CHH genes had even lower LH rises after KP54 than other men with CHH (p = 0.035). Conclusion: KP54 fully discriminated men with CHH from healthy men. Thus, KP54 could be used to specifically interrogate hypothalamic GnRH neuronal function in patients with CHH. [ABSTRACT FROM AUTHOR]

Published
2021
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40. A single bolus of the novel kisspeptin analogue, MVT-602, induces a prolonged LH surge compared to kisspeptin-54 during the follicular phase in healthy women

Author

Koteshwara Muralidhara, Maria Phylactou, Edouard Mills, Julia K Prague, Sophie Clarke, Germaine Chia, Chioma Izzi-Engbeaya, Lisa Yang, Mark Sykes, Ali Abbara, Waljit S. Dhillo, Alexander N Comninos, Sophie Jones, Machenahalli C Pratibha, Eng Pei Chia, and Deborah Papadopoulou

Subjects
medicine.medical_specialty, Endocrinology, Kisspeptin, Single bolus, business.industry, Internal medicine, Follicular phase, medicine, business
Published
2018

41. Kisspeptin- a novel clinical test of hypothalamic function in men with hypogonadotrophic hypogonadism

Author

Maria Phylactou, Chioma Izzy-Engbeaya, Waljit S. Dhillo, Sophie Clarke Ali Abbara, Deborah Papadopoulou, Lisa Yang, Eng Pei Chia, Alexander N Comninos, Muralidhara Koteshwara, Germaine Chia, Machenahalli C Pratibha, Edouard Mills, and Channa N. Jayasena

Subjects
medicine.medical_specialty, Endocrinology, Kisspeptin, business.industry, Internal medicine, Medicine, business, Hypogonadotrophic hypogonadism
Published
2018

42. Effects of Peptide YY on the Hypothalamic-Pituitary-Gonadal Axis in Healthy Men

Author

Izzi-Engbeaya, Chioma, primary, Jones, Sophie, additional, Crustna, Yoshibye, additional, Machenahalli, Pratibha C, additional, Papadopoulou, Deborah, additional, Modi, Manish, additional, Panayi, Christos, additional, Starikova, Jessica, additional, Eng, Pei Chia, additional, Phylactou, Maria, additional, Mills, Edouard, additional, Yang, Lisa, additional, Ratnasabapathy, Risheka, additional, Sykes, Mark, additional, Plumptre, Isabella, additional, Coumbe, Ben, additional, Wing, Victoria, additional, Pacuszka, Ewa, additional, Bech, Paul, additional, Minnion, James, additional, Tharakan, George, additional, Tan, Tricia, additional, Veldhuis, Johannes, additional, Abbara, Ali, additional, Comninos, Alexander N, additional, and Dhillo, Waljit S, additional

Published
2019
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43. Anti-Müllerian hormone (AMH) in the Diagnosis of Menstrual Disturbance Due to Polycystic Ovarian Syndrome

Author

Abbara, Ali, primary, Eng, Pei Chia, additional, Phylactou, Maria, additional, Clarke, Sophie A., additional, Hunjan, Tia, additional, Roberts, Rachel, additional, Vimalesvaran, Sunitha, additional, Christopoulos, George, additional, Islam, Rumana, additional, Purugganan, Kate, additional, Comninos, Alexander N., additional, Trew, Geoffrey H., additional, Salim, Rehan, additional, Hramyka, Artsiom, additional, Owens, Lisa, additional, Kelsey, Tom, additional, and Dhillo, Waljit S., additional

Published
2019
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44. FSH Requirements for Follicle Growth During Controlled Ovarian Stimulation

Author

Abbara, Ali, primary, Patel, Aaran, additional, Hunjan, Tia, additional, Clarke, Sophie A., additional, Chia, Germaine, additional, Eng, Pei Chia, additional, Phylactou, Maria, additional, Comninos, Alexander N., additional, Lavery, Stuart, additional, Trew, Geoffrey H., additional, Salim, Rehan, additional, Rai, Raj S., additional, Kelsey, Tom W., additional, and Dhillo, Waljit S., additional

Published
2019
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45. OR33-4 A Single Subcutaneous Injection Of The Kisspeptin Analogue, MVT-602, Induces A More Prolonged LH Surge Compared With Kisspeptin-54 In Healthy Women

Author

Clarke, Sophie, primary, Abbara, Ali, additional, Eng, Pei Chia, additional, Phylactou, Maria, additional, Chia, Germaine, additional, Yang, Lisa, additional, Prague, Julia, additional, Muralidhara, Koteshwara, additional, Papadopoulou, Deborah, additional, Mills, Edouard, additional, Izzi-Engbeaya, Chioma, additional, Jones, Sophie, additional, Machenahalli, C Pratibha, additional, Sykes, Mark, additional, Comninos, Alexander, additional, and Dhillo, Waljit, additional

Published
2019
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46. SAT-211 Gonadotrophin Rise Following Kisspeptin Analogue (MVT-602) Is Increased In Women With Hypothalamic Amenorrhoea Compared To Healthy Women

Author

Eng, Pei Chia, primary, Abbara, Ali, additional, Phylactou, Maria, additional, Clarke, Sophie, additional, Yang, Lisa, additional, Mills, Edouard GA, additional, Modi, Manish, additional, Papadopoulou, Deborah, additional, Plumptre, Isabella, additional, Tia, Hunjan, additional, Purugganan, Kate, additional, Webber, Lisa, additional, Salim, Rehan, additional, Comninos, Alexander, additional, and Dhillo, Waljit, additional

Published
2019
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47. SUN-LB044 Effects of Glucagon-Like Peptide-1 (GLP-1) on the Hypothalamic-Pituitary-Gonadal Axis in Healthy Men

Author

Izzi-Engbeaya, Chioma, primary, Jones, Sophie, additional, Crustna, Yoshibye, additional, Machenahalli, Pratibha, additional, Papadopoulou, Deborah, additional, Modi, Manish, additional, Panayi, Christos, additional, Starikova, Jessica, additional, Eng, Pei Chia, additional, Phylactou, Maria, additional, Mills, Edouard, additional, Yang, Lisa, additional, Ratnasabapathy, Risheka, additional, Sykes, Mark, additional, Plumptre, Bella, additional, Abbara, Ali, additional, Minnion, James, additional, Tharakan, George, additional, Tan, Tricia, additional, Veldhuis, Johannes, additional, Comninos, Alexander, additional, and Dhillo, Waljit, additional

Published
2019
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48. Clinical and biochemical characteristics of patients presenting with pituitary apoplexy

Author

Abbara, Ali, primary, Clarke, Sophie, additional, Eng, Pei Chia, additional, Milburn, James, additional, Joshi, Devavrata, additional, Comninos, Alexander N, additional, Ramli, Rozana, additional, Mehta, Amrish, additional, Jones, Brynmor, additional, Wernig, Florian, additional, Nair, Ramesh, additional, Mendoza, Nigel, additional, Sam, Amir H, additional, Hatfield, Emma, additional, Meeran, Karim, additional, Dhillo, Waljit S, additional, and Martin, Niamh M, additional

Published
2018
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49. The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans

Author

Izzi-Engbeaya, Chioma, primary, Comninos, Alexander N., additional, Clarke, Sophie A., additional, Jomard, Anne, additional, Yang, Lisa, additional, Jones, Sophie, additional, Abbara, Ali, additional, Narayanaswamy, Shakunthala, additional, Eng, Pei Chia, additional, Papadopoulou, Deborah, additional, Prague, Julia K., additional, Bech, Paul, additional, Godsland, Ian F., additional, Bassett, Paul, additional, Sands, Caroline, additional, Camuzeaux, Stephane, additional, Gomez-Romero, Maria, additional, Pearce, Jake T. M., additional, Lewis, Matthew R., additional, Holmes, Elaine, additional, Nicholson, Jeremy K., additional, Tan, Tricia, additional, Ratnasabapathy, Risheka, additional, Hu, Ming, additional, Carrat, Gaelle, additional, Piemonti, Lorenzo, additional, Bugliani, Marco, additional, Marchetti, Piero, additional, Johnson, Paul R., additional, Hughes, Stephen J., additional, James Shapiro, A. M., additional, Rutter, Guy A., additional, and Dhillo, Waljit S., additional

Published
2018
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50. Thyroid Function Before, During, and After COVID-19

Author

Khoo, Bernard, Tan, Tricia, Clarke, Sophie A, Mills, Edouard G, Patel, Bijal, Modi, Manish, Phylactou, Maria, Eng, Pei Chia, Thurston, Layla, Alexander, Emma C, Meeran, Karim, Comninos, Alexander N, Abbara, Ali, and Dhillo, Waljit S

Published
2021
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