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2. The Predictivity of Access Tests for University Success

Author

Genova, Vincenzo Giuseppe, Attanasio, Massimo, Enea, Marco, Gaul, Wolfgang, Managing Editor, Vichi, Maurizio, Managing Editor, Weihs, Claus, Managing Editor, Baier, Daniel, Editorial Board Member, Critchley, Frank, Editorial Board Member, Decker, Reinhold, Editorial Board Member, Diday, Edwin, Editorial Board Member, Greenacre, Michael, Editorial Board Member, Lauro, Carlo Natale, Editorial Board Member, Meulman, Jacqueline, Editorial Board Member, Monari, Paola, Editorial Board Member, Nishisato, Shizuhiko, Editorial Board Member, Ohsumi, Noboru, Editorial Board Member, Opitz, Otto, Editorial Board Member, Ritter, Gunter, Editorial Board Member, Schader, Martin, Editorial Board Member, Davino, Cristina, editor, Palumbo, Francesco, editor, Wilhelm, Adalbert F. X., editor, and Kestler, Hans A., editor

Published
2024
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5. Oesophageal varices predict complications in compensated advanced non-alcoholic fatty liver disease

Author

Pennisi, Grazia, Enea, Marco, Viganò, Mauro, Schepis, Filippo, de Ledinghen, Victor, Berzigotti, Annalisa, Wai-Sun Wong, Vincent, Fracanzani, Anna Ludovica, Sebastiani, Giada, Lara-Romero, Carmen, Bugianesi, Elisabetta, Svegliati-Baroni, Gianluca, Marra, Fabio, Aghemo, Alessio, Valenti, Luca, Calvaruso, Vincenza, Colecchia, Antonio, Di Maria, Gabriele, La Mantia, Claudia, Lin, Huapeng, Mendoza, Yuly P., Pugliese, Nicola, Ravaioli, Federico, Romero-Gomez, Manuel, Saltini, Dario, Craxì, Antonio, Di Marco, Vito, Cammà, Calogero, and Petta, Salvatore

Published
2023
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7. FRI-317 Clinical outcomes of metabolic liver disease versus non-alcoholic fatty liver disease: a meta-analysis of observational studies

Author

Pennisi, Grazia, primary, Infantino, Giuseppe, additional, Celsa, Ciro, additional, Maria, Gabriele Di, additional, Enea, Marco, additional, Vaccaro, Marco, additional, Cannella, Roberto, additional, Ciccioli, Carlo, additional, La Mantia, Claudia, additional, Mantovani, Alessandro, additional, Mercurio, Francesco, additional, Tilg, Herbert, additional, Targher, Giovanni, additional, Marco, Vito Di, additional, Camma, Calogero, additional, and Petta, Salvatore, additional

Published
2024
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8. SAT-209-YI A Markov model unveiling the impact of Resmetirom on the natural history of MASLD patients with baseline significant or severe liver fibrosis

Author

Pennisi, Grazia, primary, Di Maria, Gabriele, additional, Enea, Marco, additional, Vaccaro, Marco, additional, Ciccioli, Carlo, additional, Celsa, Ciro, additional, Infantino, Giuseppe, additional, Tulone, Adele, additional, Di Marco, Vito, additional, Camma, Calogero, additional, and Petta, Salvatore, additional

Published
2024
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9. High-Resolution Gridded Air Temperature Data for the Urban Environment: The Milan Data Set

Author

Giuseppe Frustaci, Samantha Pilati, Cristina Lavecchia, and Enea Marco Montoli

Subjects
urban meteorology, LST, cokriging, UrbClim, WRF-BEP, Science (General), Q1-390, Mathematics, QA1-939
Abstract

Temperature is the most used meteorological variable for a large number of applications in urban resilience planning, but direct measurements using traditional sensors are not affordable at the usually required spatial density. On the other hand, spaceborne remote sensing provides surface temperatures at medium to high spatial resolutions, almost compatible with the needed requirements. However, in this case, limitations are represented by cloud conditions and passing times together with the fact that surface temperature is not directly comparable to air temperature. Various methodologies are possible to take benefits from both measurements and analysis methods, such as direct assimilation in numerical models, multivariate analysis, or statistical interpolation. High-resolution thermal fields in the urban environment are also obtained by numerical modelling. Several codes have been developed to resolve at some level or to parameterize the complex urban boundary layer and are used for research and applications. Downscaling techniques from global or regional models offer another possibility. In the Milan metropolitan area, given the availability of both a high-quality urban meteorological network and spaceborne land surface temperatures, and also modelling and downscaling products, these methods can be directly compared. In this paper, the comparison is performed using: the ClimaMi Project high-quality data set with the accurately selected measurements in the Milan urban canopy layer, interpolated by a cokriging technique with remote-sensed land surface temperatures to enhance spatial resolution; the UrbClim downscaled data from the reanalysis data set ERA5; a set of near-surface temperatures produced by some WRF outputs with the building environment parameterization urban scheme. The comparison with UrbClim and WRF of the cokriging interpolated data set, mainly based on the urban canopy layer measurements and covering several years, is presented and discussed in this article. This comparison emphasizes the primary relevance of surface urban measurements and highlights discrepancies with the urban modelling data sets.

Published
2022
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11. Monitoring Occurrence of Liver-Related Events and Survival by Transient Elastography in Patients With Nonalcoholic Fatty Liver Disease and Compensated Advanced Chronic Liver Disease

Author

Petta, Salvatore, Sebastiani, Giada, Viganò, Mauro, Ampuero, Javier, Wai-Sun Wong, Vincent, Boursier, Jerome, Berzigotti, Annalisa, Bugianesi, Elisabetta, Fracanzani, Anna Ludovica, Cammà, Calogero, Enea, Marco, Grottes, Marraud des, Di Marco, Vito, Younes, Ramy, Keyrouz, Aline, Mazzola, Sergio, Mendoza, Yuly, Pennisi, Grazia, Romero-Gomez, Manuel, Craxì, Antonio, and de Ledinghen, Victor

Published
2021
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14. A penalized approach to the bivariate logistic regression model for the association between ordinal responses

Author

Enea, Marco and Lovison, Gianfranco

Subjects
Mathematics - Statistics Theory, Statistics - Applications, Statistics - Computation, Statistics - Methodology
Abstract

Bivariate ordered logistic models (BOLMs) are appealing to jointly model the marginal distribution of two ordered responses and their association, given a set of covariates. When the number of categories of the responses increases, the number of global odds ratios (or their re-parametrizations) to be estimated also increases and estimating the association structure becomes crucial for this type of data. In fact, such data could be too "rich" to be fully modelled with an ordinary BOLM while, sometimes, the well-known Dale's model could be too parsimonious to provide a good fit. In addition, when the cross-tabulation of the responses contains some zeros, for a number of model configurations, including the bivariate version of the partial proportional odds model (PPOM), estimation of a BOLM by the Fisher-scoring algorithm may either fail or estimate a too "irregular" association structure. In this work, we propose to use a nonparametric approach for the maximum likelihood estimation of a BOLM. We apply penalties to the differences between adjacent row and column effects. As a result, estimation is less demanding than an ordinary BOLM, permitting the fit of PPOMs and/or the smoothing of the marginal and association parameters by polynomial curves and surfaces, with scores chosen by the data. Model selection is based on the penalized log-likelihood ratio, whose limiting distribution has been studied through simulations, and AIC. Our proposal is compared to the Goodman's model and the Dale's model, in terms of goodness-of-fit and parsimony, on a literature data set. Finally, an application on an original data set of liver disease patients is proposed.

Published
2014

15. Competing-risk analysis of coronavirus disease 2019 in-hospital mortality in a Northern Italian centre from SMAtteo COvid19 REgistry (SMACORE)

Author

Zuccaro, Valentina, Celsa, Ciro, Sambo, Margherita, Battaglia, Salvatore, Sacchi, Paolo, Biscarini, Simona, Valsecchi, Pietro, Pieri, Teresa Chiara, Gallazzi, Ilaria, Colaneri, Marta, Sachs, Michele, Roda, Silvia, Asperges, Erika, Lupi, Matteo, Di Filippo, Alessandro, Seminari, Elena, Di Matteo, Angela, Novati, Stefano, Maiocchi, Laura, Enea, Marco, Attanasio, Massimo, Cammà, Calogero, and Bruno, Raffaele

Published
2021
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17. Risk of liver-related events in metabolic dysfunction–associated steatohepatitis (MASH) patients with fibrosis: A comparative analysis of various risk stratification criteria.

Author

Pennisi, Grazia, Enea, Marco, Romero-Gomez, Manuel, Bugianesi, Elisabetta, Wai-Sun Wong, Vincent, Fracanzani, Anna Ludovica, de Ledinghen, Victor, George, Jacob, Berzigotti, Annalisa, Viganò, Mauro, Sebastiani, Giada, Cannella, Roberto, Delamarre, Adèle, Di Maria, Gabriele, Lange, Naomi F., Tulone, Adele, Di Marco, Vito, Cammà, Calogero, and Petta, Salvatore

Published
2024
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18. Balancing Efficacy and Tolerability of First-Line Systemic Therapies for Advanced Hepatocellular Carcinoma: A Network Meta-Analysis.

Author

Celsa, Ciro, Cabibbo, Giuseppe, Pinato, David James, Di Maria, Gabriele, Enea, Marco, Vaccaro, Marco, Battaglia, Salvatore, Rizzo, Giacomo Emanuele Maria, Giuffrida, Paolo, Giacchetto, Carmelo Marco, Rancatore, Gabriele, Grassini, Maria Vittoria, and Cammà, Calogero

Subjects
IMMUNE checkpoint inhibitors, SURVIVAL rate, PROTEIN-tyrosine kinase inhibitors, OVERALL survival, ENDOTHELIAL growth factors, HEPATOCELLULAR carcinoma
Abstract

Background: Atezolizumab + bevacizumab represent the current standard of care for first-line treatment of advanced hepatocellular carcinoma (HCC). However, direct comparison with other combination treatments including immune checkpoint inhibitors (ICI) + tyrosine kinase inhibitors (TKIs) are lacking. Objectives: This network meta-analysis (NMA) aims to indirectly compare the efficacy and the safety of first-line systemic therapies for unresectable advanced HCC. Method: A literature search of MEDLINE, Embase, and SCOPUS databases was conducted up to October 31, 2022. Phase 3 randomized controlled trials (RCTs) testing TKIs, including sorafenib and lenvatinib, or ICIs reporting overall survival (OS) and progression-free survival (PFS) were included. Individual survival data were extracted from OS and PFS curves to calculate restricted mean survival time. A Bayesian NMA was performed to compare treatments in terms of efficacy (15- and 30-month OS, 6-month PFS) and safety, represented by grade ≥3 (severe) adverse events (SAEs). The incremental safety-effectiveness ratio as measure of net health benefit was calculated as the difference in SAE probability divided by survival difference between the 2 most effective treatments. Results: Nine RCTs enrolling 6,600 patients were included. Atezolizumab plus bevacizumab showed the highest probability (88%) of achieving the 30-month OS landmark. Lenvatinib showed a probability of 86% of achieving best PFS outcomes. ICI monotherapies ranked as most tolerable. Atezolizumab plus bevacizumab showed the best net health benefit for OS, compared to durvalumab plus tremelimumab. When evaluating the net health benefit for PFS, at a willingness-to-risk threshold of 10% of SAEs for life-month gained, atezolizumab plus bevacizumab was favoured in 78% of cases, while at threshold of 30% of SAEs for life-month gained, lenvatinib was favoured in 76% of cases. Conclusions: Atezolizumab plus bevacizumab is the best treatment in terms of net benefit and therefore it should be recommended as standard of care. Compared to atezolizumab plus bevacizumab, lenvatinib monotherapy had the best net benefit for PFS when physicians and patients are available to accept a higher risk of toxicity. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Risk of liver-related events in metabolic dysfunction–associated steatohepatitis (MASH) patients with fibrosis: A comparative analysis of various risk stratification criteria

Author

Pennisi, Grazia, primary, Enea, Marco, additional, Romero-Gomez, Manuel, additional, Bugianesi, Elisabetta, additional, Wai-Sun Wong, Vincent, additional, Fracanzani, Anna Ludovica, additional, de Ledinghen, Victor, additional, George, Jacob, additional, Berzigotti, Annalisa, additional, Viganò, Mauro, additional, Sebastiani, Giada, additional, Cannella, Roberto, additional, Delamarre, Adèle, additional, Di Maria, Gabriele, additional, Lange, Naomi F., additional, Tulone, Adele, additional, Di Marco, Vito, additional, Cammà, Calogero, additional, and Petta, Salvatore, additional

Published
2023
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20. Balancing Efficacy and Tolerability of First-Line Systemic Therapies for Advanced Hepatocellular Carcinoma: A Network Meta-Analysis

Author

Celsa, Ciro, primary, Cabibbo, Giuseppe, additional, Pinato, David James, additional, Di Maria, Gabriele, additional, Enea, Marco, additional, Vaccaro, Marco, additional, Battaglia, Salvatore, additional, Rizzo, Giacomo Emanuele Maria, additional, Giuffrida, Paolo, additional, Giacchetto, Carmelo Marco, additional, Rancatore, Gabriele, additional, Grassini, Maria Vittoria, additional, and Cammà, Calogero, additional

Published
2023
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21. Serological status for TORCH in women of childbearing age: a decade-long surveillance (2012–2022) in Italy

Author

Palazzotto, Emilia, primary, Bonura, Floriana, additional, Calà, Cinzia, additional, Capra, Giuseppina, additional, Pistoia, Daniela, additional, Mangione, Donatella, additional, Mascarella, Chiara, additional, Minì, Giuseppe, additional, Enea, Marco, additional, Giammanco, Giovanni M., additional, Ferraro, Donatella, additional, and De Grazia, Simona, additional

Published
2023
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22. Balancing efficacy and tolerability of first-line systemic therapies for advanced hepatocellular carcinoma: a network metanalysis

Author

Celsa, Ciro, primary, Cabibbo, Giuseppe, additional, Di Maria, Gabriele, additional, Vaccaro, Marco, additional, Battaglia, Salvatore, additional, Maria Rizzo, Giacomo Emanuele, additional, Ciccia, Roberta, additional, Grova, Alessandro, additional, Salvato, Mauro, additional, Giuffrida, Paolo, additional, Giacchetto, Marco, additional, Rancatore, Gabriele, additional, Grassini, Maria Vittoria, additional, Antonucci, Michela, additional, Morana, Piera, additional, Enea, Marco, additional, and Camma, Calogero, additional

Published
2023
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23. Programmed cell death 1 genetic variant and liver damage in non-alcoholic fatty liver disease

Author

Pennisi, Grazia, primary, Pipitone, Rosaria Maria, additional, Malvestiti, Francesco, additional, Jamialahmadi, Oveis, additional, Dongiovanni, Paola, additional, Bertolazzi, Giorgio, additional, Pihlajamaki, Jussi, additional, Yki-Järvinen, Hannele, additional, Gentilucci, Umberto Vespasiani, additional, Tavaglione, Federica, additional, Maurotti, Samantha, additional, Bianco, Cristiana, additional, Di Maria, Gabriele, additional, Enea, Marco, additional, Fracanzani, Anna Ludovica, additional, Kärjä, Vesa, additional, Lupo, Giulia, additional, Männistö, Ville, additional, Meroni, Marica, additional, Piciotti, Roberto, additional, Qadri, Sami, additional, Zito, Rossella, additional, Craxi, Antonio, additional, Di Marco, Vito, additional, Camma, Calogero, additional, Tripodo, Claudio, additional, Valenti, Luca, additional, Romeo, Stefano, additional, Petta, Salvatore, additional, and Grimaudo, Stefania, additional

Published
2023
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24. Presence and severity of esophageal varices drives portal hypertension-related complications in compensated advanced non-alcoholic fatty liver disease

Author

Pennisi, Grazia, primary, Enea, Marco, additional, Viganò, Mauro, additional, Schepis, Filippo, additional, de Lédinghen, Victor, additional, Berzigotti, Annalisa, additional, Wong, Vincent Wai-Sun, additional, Fracanzani, Anna Ludovica, additional, Sebastiani, Giada, additional, Gomez, Manuel Romero, additional, Bugianesi, Elisabetta, additional, Svegliati-Baroni, Gianluca, additional, Marra, Fabio, additional, Aghemo, Alessio, additional, Valenti, Luca, additional, Calvaruso, Vincenza, additional, Colecchia, Antonio, additional, Di Maria, Gabriele, additional, La Mantia, Claudia, additional, Lin, Huapeng, additional, Mendoza, Yuly, additional, Pugliese, Nicola, additional, Ravaioli, Federico, additional, Lara-Romero, Carmen, additional, Saltini, Dario, additional, Craxi, Antonio, additional, Di Marco, Vito, additional, Camma, Calogero, additional, and Petta, Salvatore, additional

Published
2023
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25. Risk factors for viral reactivation in patients with overt or occult HepatitisB Virus infection receiving immunosuppressive treatments: a systematic review and meta-analysis

Author

Celsa, Ciro, primary, Maria Rizzo, Giacomo Emanuele, additional, Rancatore, Gabriele, additional, Graceffa, Pietro, additional, Falco, Giuseppe, additional, Di Maria, Gabriele, additional, Vaccaro, Marco, additional, Enea, Marco, additional, Calvaruso, Vincenza, additional, Camma, Calogero, additional, and Di Marco, Vito, additional

Published
2023
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26. The Performance of the Gradient-Like Influence Measure in Generalized Linear Mixed Models

Author

Enea, Marco, Plaia, Antonella, Arabie, Phipps, Series editor, Gaul, Wolfgang, Editor-in-chief, Baier, Daniel, Series editor, Vichi, Maurizio, Editor-in-chief, Bock, Hans-Hermann, Series editor, Bodendorf, Freimut, Series editor, Bryant, Peter G., Series editor, Critchley, Frank, Series editor, Decker, Reinhold, Series editor, Diday, Edwin, Series editor, Greenacre, Michael, Series editor, Ihm, Peter, Series editor, Wille, Rudolf, Series editor, Lauro, Carlo Natale, Series editor, Radermacher, Franz Josef, Series editor, Meulman, Jacqueline, Series editor, Monari, Paola, Series editor, Nishisato, Shizuhiko, Series editor, Ohsumi, Noboru, Series editor, Opitz, Otto, Series editor, Ritter, Gunter, Series editor, Schader, Martin, Series editor, Weihs, Claus, Editor-in-chief, Morlini, Isabella, editor, and Minerva, Tommaso, editor

Published
2015
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27. Programmed cell death 1 genetic variant and liver damage in nonalcoholic fatty liver disease

Author

Pipitone, Rosaria M., primary, Malvestiti, Francesco, additional, Pennisi, Grazia, additional, Jamialahmadi, Oveis, additional, Dongiovanni, Paola, additional, Bertolazzi, Giorgio, additional, Pihlajamäki, Jussi, additional, Yki‐Järvinen, Hannele, additional, Vespasiani‐Gentilucci, Umberto, additional, Tavaglione, Federica, additional, Maurotti, Samantha, additional, Bianco, Cristiana, additional, Di Maria, Gabriele, additional, Enea, Marco, additional, Fracanzani, Anna L., additional, Kärjä, Vesa, additional, Lupo, Giulia, additional, Männistö, Ville, additional, Meroni, Marica, additional, Piciotti, Roberto, additional, Qadri, Sami, additional, Zito, Rossella, additional, Craxì, Antonio, additional, Di Marco, Vito, additional, Cammà, Calogero, additional, Tripodo, Claudio, additional, Valenti, Luca, additional, Romeo, Stefano, additional, Petta, Salvatore, additional, and Grimaudo, Stefania, additional

Published
2023
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28. Noninvasive assessment of liver disease severity in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes

Author

Pennisi, Grazia, primary, Enea, Marco, additional, Falco, Vincenzo, additional, Aithal, Guruprasad P., additional, Palaniyappan, Naaventhan, additional, Yilmaz, Yusuf, additional, Boursier, Jerome, additional, Cassinotto, Christophe, additional, de Lédinghen, Victor, additional, Chan, Wah Kheong, additional, Mahadeva, Sanjiv, additional, Eddowes, Peter, additional, Newsome, Philip, additional, Karlas, Thomas, additional, Wiegand, Johannes, additional, Wong, Vincent Wai-Sun, additional, Schattenberg, Jörn M., additional, Labenz, Christian, additional, Kim, Won, additional, Lee, Myoung Seok, additional, Lupsor-Platon, Monica, additional, Cobbold, Jeremy F. L., additional, Fan, Jian-Gao, additional, Shen, Feng, additional, Staufer, Katharina, additional, Trauner, Michael, additional, Stauber, Rudolf, additional, Nakajima, Atsushi, additional, Yoneda, Masato, additional, Bugianesi, Elisabetta, additional, Younes, Ramy, additional, Gaia, Silvia, additional, Zheng, Ming-Hua, additional, Cammà, Calogero, additional, Anstee, Quentin M., additional, Mózes, Ferenc Emil, additional, Pavlides, Michael, additional, and Petta, Salvatore, additional

Published
2023
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29. Reply

Author

Vizzutti, Francesco, primary, Celsa, Ciro, additional, Battaglia, Salvatore, additional, Miraglia, Roberto, additional, Enea, Marco, additional, Marra, Fabio, additional, Colecchia, Antonio, additional, Cammà, Calogero, additional, and Schepis, Filippo, additional

Published
2023
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30. Oesophageal varices predict complications in compensated advanced non-alcoholic fatty liver disease

Author

Ministero dell'Istruzione e del Merito, Fonds de Recherche du Québec, Pennisi, Grazia, Enea, Marco, Viganò, Mauro, Schepis, Filippo, Ledinghen, Victor de, Berzigotti, Annalisa, Wai-Sun Wong, Vincent, Fracanzani, Anna Ludovica, Sebastiani, Giada, Lara-Romero, Carmen, Bugianesi, Elisabetta, Svegliati-Baroni, Gianluca, Marra, Fabio, Aghemo, Alessio, Valenti, Luca, Calvaruso, Vincenza, Colecchia, Antonio, Di Maria, Gabriele, La Mantia, Claudia, Lin, Huapeng, Mendoza, Yuly, Pugliese, Nicola, Ravaioli, Federico, Romero-Gómez, Manuel, Saltini, Dario, Craxi, Antonio, Di Marco, Vito, Cammà, Calogero, Petta, Salvatore, Ministero dell'Istruzione e del Merito, Fonds de Recherche du Québec, Pennisi, Grazia, Enea, Marco, Viganò, Mauro, Schepis, Filippo, Ledinghen, Victor de, Berzigotti, Annalisa, Wai-Sun Wong, Vincent, Fracanzani, Anna Ludovica, Sebastiani, Giada, Lara-Romero, Carmen, Bugianesi, Elisabetta, Svegliati-Baroni, Gianluca, Marra, Fabio, Aghemo, Alessio, Valenti, Luca, Calvaruso, Vincenza, Colecchia, Antonio, Di Maria, Gabriele, La Mantia, Claudia, Lin, Huapeng, Mendoza, Yuly, Pugliese, Nicola, Ravaioli, Federico, Romero-Gómez, Manuel, Saltini, Dario, Craxi, Antonio, Di Marco, Vito, Cammà, Calogero, and Petta, Salvatore

Abstract

[Background & Aims] We aimed to evaluate the impact of oesophageal varices (OV) and their evolution on the risk of complications of compensated advanced chronic liver disease (cACLD) caused by non-alcoholic fatty liver disease (NAFLD). We also assessed the accuracy of non-invasive scores for predicting the development of complications and for identifying patients at low risk of high-risk OV., [Methods] We performed a retrospective assessment of 629 patients with NAFLD-related cACLD who had baseline and follow-up oesophagogastroduodenoscopy and clinical follow-up to record decompensation, portal vein thrombosis (PVT), and hepatocellular carcinoma., [Results] Small and large OV were observed at baseline in 30 and 15.9% of patients, respectively. The 4-year incidence of OV from absence at baseline, and that of progression from small to large OV were 16.3 and 22.4%, respectively. Diabetes and a ≥5% increase in BMI were associated with OV progression. Multivariate Cox regression revealed that small (hazard ratio [HR] 2.24, 95% CI 1.47–3.41) and large (HR 3.86, 95% CI 2.34–6.39) OV were independently associated with decompensation. When considering OV status and trajectories, small (HR 2.65, 95% CI 1.39–5.05) and large (HR 4.90, 95% CI 2.49–9.63) OV at baseline and/or follow-up were independently associated with decompensation compared with the absence of OV at baseline and/or follow-up. The presence of either small (HR 2.8, 95% CI 1.16–6.74) or large (HR 5.29, 95% CI 1.96–14.2) OV was also independently associated with incident PVT., [Conclusion] In NAFLD-related cACLD, the presence, severity, and evolution of OV stratify the risk of developing decompensation and PVT., [Impact and implications] Portal hypertension is the main driver of liver decompensation in chronic liver diseases, and its non-invasive markers can help risk prediction. The presence, severity, and progression of oesophageal varices stratify the risk of complications of non-alcoholic fatty liver disease. Easily obtainable laboratory values and liver stiffness measurement can identify patients at low risk for whom endoscopy may be withheld, and can also stratify the risk of liver-related complications.

Published
2023

31. Influence Diagnostics for Meta-Analysis of Individual Patient Data Using Generalized Linear Mixed Models

Author

Enea, Marco, Plaia, Antonella, Bock, Hans-Hermann, Editor-in-chief, Gaul, Wolfgang, Editor-in-chief, Baier, Daniel, Series editor, Vichi, Maurizio, Editor-in-chief, Critchley, Frank, Series editor, Decker, Reinhold, Series editor, Diday, Edwin, Series editor, Greenacre, Michael, Series editor, Lauro, Carlo Natale, Series editor, Meulman, Jacqueline, Series editor, Monari, Paola, Series editor, Nishisato, Shizuhiko, Series editor, Ohsumi, Noboru, Series editor, Opitz, Otto, Series editor, Ritter, Gunter, Series editor, Schader, Martin, Series editor, Weihs, Claus, Editor-in-chief, Vicari, Donatella, editor, Okada, Akinori, editor, and Ragozini, Giancarlo, editor

Published
2014
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33. Reply

Author

Vizzutti, Francesco, primary, Celsa, Ciro, additional, Battaglia, Salvatore, additional, Miraglia, Roberto, additional, Enea, Marco, additional, Marra, Fabio, additional, Caporali, Cristian, additional, Cammà, Calogero, additional, and Schepis, Filippo, additional

Published
2022
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34. Effect of pharmacological interventions and placebo on liver Histology in nonalcoholic steatohepatitis: A network meta-analysis

Author

Pennisi, Grazia, primary, Celsa, Ciro, additional, Enea, Marco, additional, Vaccaro, Marco, additional, Di Marco, Vito, additional, Ciccioli, Carlo, additional, Infantino, Giuseppe, additional, La Mantia, Claudia, additional, Parisi, Stefanie, additional, Vernuccio, Federica, additional, Craxì, Antonio, additional, Cammà, Calogero, additional, and Petta, Salvatore, additional

Published
2022
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35. Endothelial angiopoietin-2 overexpression in explanted livers identifies subjects at higher risk of recurrence of hepatocellular carcinoma after liver transplantation

Author

Lasagni, Simone, primary, Leonardi, Filippo, additional, Pivetti, Alessandra, additional, Di Marco, Lorenza, additional, Ravaioli, Federico, additional, Serenari, Matteo, additional, Gitto, Stefano, additional, Critelli, Rosina Maria, additional, Milosa, Fabiola, additional, Romanzi, Adriana, additional, Mancarella, Serena, additional, Dituri, Francesco, additional, Riefolo, Mattia, additional, Catellani, Barbara, additional, Magistri, Paolo, additional, Romagnoli, Dante, additional, Celsa, Ciro, additional, Enea, Marco, additional, de Maria, Nicola, additional, Schepis, Filippo, additional, Colecchia, Antonio, additional, Cammà, Calogero, additional, Cescon, Matteo, additional, d’Errico, Antonietta, additional, di Benedetto, Fabrizio, additional, Giannelli, Gianluigi, additional, Martinez-Chantar, Maria Luz, additional, and Villa, Erica, additional

Published
2022
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37. Mortality after transjugular intrahepatic portosystemic shunt in older adult patients with cirrhosis: A validated prediction model

Author

Vizzutti, Francesco, primary, Celsa, Ciro, additional, Calvaruso, Vincenza, additional, Enea, Marco, additional, Battaglia, Salvatore, additional, Turco, Laura, additional, Senzolo, Marco, additional, Nardelli, Silvia, additional, Miraglia, Roberto, additional, Roccarina, Davide, additional, Campani, Claudia, additional, Saltini, Dario, additional, Caporali, Cristian, additional, Indulti, Federica, additional, Gitto, Stefano, additional, Zanetto, Alberto, additional, Di Maria, Gabriele, additional, Bianchini, Marcello, additional, Pecchini, Maddalena, additional, Aspite, Silvia, additional, Di Bonaventura, Chiara, additional, Citone, Michele, additional, Guasconi, Tomas, additional, Di Benedetto, Fabrizio, additional, Arena, Umberto, additional, Fanelli, Fabrizio, additional, Maruzzelli, Luigi, additional, Riggio, Oliviero, additional, Burra, Patrizia, additional, Colecchia, Antonio, additional, Villa, Erica, additional, Marra, Fabio, additional, Cammà, Calogero, additional, and Schepis, Filippo, additional

Published
2022
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39. RESIST-HCV Criteria to Monitor Progression of Low-Risk Esophageal Varices in Patients With Compensated Cirrhosis After HCV Eradication: The SIMPLE Study: SIMPLE: Scoring Index to Monitor Progression of Low-risk Esophageal varices

Author

Calvaruso, Vincenza, Celsa, Ciro, D'Ambrosio, Roberta, Simone, Fabio, Petta, Salvatore, Cacciola, Irene, Enea, Marco, Battaglia, Salvatore, Pandolfo, Alessandra, Licata, Massimo, Degasperi, Elisabetta, Cabibbo, Giuseppe, Di Marco, Lorenza, Pennisi, Grazia, Borghi, Marta, Di Martino, Vincenzo, Filomia, Roberto, Abdel-Hadi, Yasmin, Crapanzano, Luciano, Raimondo, Giovanni, Lampertico, Pietro, Craxì, Antonio, Cammà, Calogero, Di Marco, Vito, Calvaruso, Vincenza, Celsa, Ciro, D'Ambrosio, Roberta, Simone, Fabio, Petta, Salvatore, Cacciola, Irene, Enea, Marco, Battaglia, Salvatore, Pandolfo, Alessandra, Licata, Massimo, Degasperi, Elisabetta, Cabibbo, Giuseppe, Di Marco, Lorenza, Pennisi, Grazia, Borghi, Marta, Di Martino, Vincenzo, Filomia, Roberto, Abdel-Hadi, Yasmin, Crapanzano, Luciano, Raimondo, Giovanni, Lampertico, Pietro, Craxì, Antonio, Cammà, Calogero, and Di Marco, Vito

Subjects
Antiviral Agent, Male, Liver Cirrhosis, Hepatology, Platelet Count, Liver Cirrhosi, Gastroenterology, Hepacivirus, Hepatitis C, Chronic, Esophageal and Gastric Varices, Antiviral Agents, Elasticity Imaging Techniques, Esophageal and Gastric Varice, Humans, Female, Serum Albumin, Human, Aged
Abstract

Noninvasive criteria to predict the progression of low-risk esophageal varices (EV) in patients with compensated hepatitis C virus (HCV) cirrhosis after sustained virological response (SVR) by direct-acting antivirals (DAAs) are lacking. Our aim was to assess the diagnostic performance of Rete Sicilia Selezione Terapia-HCV (RESIST-HCV) criteria for EV progression compared with elastography-based criteria (Baveno VI, Expanded Baveno VI, and Baveno VII-HCV criteria).All consecutive patients observed at 3 referral centers with compensated HCV cirrhosis with or without F1 EV who achieved sustained virological response by DAAs were classified at last esophagogastroduodenoscopy (EGDS) as RESIST-HCV low risk (i.e., low probability of high-risk varices [HRV]) if platelets were120 × 10 9 /L and serum albumin3.6 g/dL or RESIST-HCV high risk (i.e., high probability of HRV) if platelets were120 × 10 9 /L or serum albumin3.6 g/dL. The primary outcome was the progression to HRV. The area under the receiver operating characteristic curve and decision curve analysis of noninvasive criteria were calculated.The cohort consisted of 353 patients in Child-Pugh class A (mean age 67.2 years, 53.8% males). During a mean follow-up of 44.2 months, 34 patients (9.6%, 95% CI 6.7%-13.5%) developed HRV. At the last EGDS, 178 patients (50.4%) were RESIST-low risk, and 175 (49.6%) were RESIST-high risk. RESIST-HCV criteria showed the highest area under the receiver operating characteristic curve (0.70, 95% confidence interval 0.65-0.75), correctly sparing the highest number of EGDS (54.3%), with the lowest false-positive rate (45.7%), compared with elastography-based criteria. Decision curve analysis showed that RESIST-HCV had higher clinical utility than elastography-based criteria.Biochemical-based RESIST-HCV criteria are useful to easily predict HRV development after HCV eradication by DAAs in patients with compensated cirrhosis and low-risk EV.

Published
2022

40. Efficacy and safety of Atezolizumab plus Bevacizumab-based sequential treatment for unresectable hepatocellular carcinoma: a simulation model

Author

Celsa, Ciro, primary, Cabibbo, Giuseppe, additional, Battaglia, Salvatore, additional, Giuffrida, Paolo, additional, Maria Rizzo, Giacomo Emanuele, additional, Grova, Mauro, additional, Giacchetto, Marco, additional, Rancatore, Gabriele, additional, Stornello, Caterina, additional, Grassini, Maria Vittoria, additional, Badalamenti, Giuseppe, additional, Enea, Marco, additional, Craxi, Antonio, additional, Di Marco, Vito, additional, and Camma, Calogero, additional

Published
2022
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41. AGILE 3+ Score for the Diagnosis of Advanced Fibrosis and for Predicting Liver-related Events in NAFLD

Author

Pennisi, Grazia, primary, Enea, Marco, additional, Pandolfo, Alessandra, additional, Celsa, Ciro, additional, Antonucci, Michela, additional, Ciccioli, Carlo, additional, Infantino, Giuseppe, additional, La Mantia, Claudia, additional, Parisi, Stefanie, additional, Tulone, Adele, additional, Di Marco, Vito, additional, Craxì, Antonio, additional, Cammà, Calogero, additional, and Petta, Salvatore, additional

Published
2022
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42. Spontaneous and drug-induced histological changes in non-alcoholic steatohepatitis: an assessment by meta-analysis of trials

Author

Pennisi, Grazia, primary, Celsa, Ciro, additional, Enea, Marco, additional, Vaccaro, Marco, additional, Di Marco, Vito, additional, Ciccioli, Carlo, additional, Infantino, Giuseppe, additional, Parisi, Stefanie, additional, La Mantia, Claudia, additional, Craxi, Antonio, additional, Camma, Calogero, additional, and Petta, Salvatore, additional

Published
2022
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43. Diagnostic performance of AGILE 3+ score for identification of advanced fibrosis and prediction of liver-related events in patients with non-alcoholic fatty liver disease

Author

Pennisi, Grazia, primary, Celsa, Ciro, additional, Enea, Marco, additional, Pandolfo, Alessandra, additional, Antonucci, Michela, additional, Ciccioli, Carlo, additional, Infantino, Giuseppe, additional, La Mantia, Claudia, additional, Parisi, Stefanie, additional, Tulone, Adele, additional, Di Marco, Vito, additional, Craxi, Antonio, additional, Camma, Calogero, additional, and Petta, Salvatore, additional

Published
2022
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44. Radiomics Analysis on Gadoxetate Disodium-Enhanced MRI Predicts Response to Transarterial Embolization in Patients with HCC

Author

Cannella, Roberto, primary, Cammà, Carla, additional, Matteini, Francesco, additional, Celsa, Ciro, additional, Giuffrida, Paolo, additional, Enea, Marco, additional, Comelli, Albert, additional, Stefano, Alessandro, additional, Cammà, Calogero, additional, Midiri, Massimo, additional, Lagalla, Roberto, additional, Brancatelli, Giuseppe, additional, and Vernuccio, Federica, additional

Published
2022
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45. Hepatocellular carcinoma recurrence after direct-acting antiviral therapy: An individual patient data meta-analysis

Author

Universidad de Sevilla. Departamento de Medicina, Sapena, Victor, Enea, Marco, Torres, Ferran, Celsa, Ciro, Ríos, José J., Rizzo, Giacomo Emanuele Maria, Nahon, Pierre, Merchante Gutiérrez, Nicolás, Reig, Maria, Universidad de Sevilla. Departamento de Medicina, Sapena, Victor, Enea, Marco, Torres, Ferran, Celsa, Ciro, Ríos, José J., Rizzo, Giacomo Emanuele Maria, Nahon, Pierre, Merchante Gutiérrez, Nicolás, and Reig, Maria

Abstract

Objective The benefit of direct-acting antivirals (DAAs) against HCV following successful treatment of hepatocellular carcinoma (HCC) remains controversial. This meta-analysis of individual patient data assessed HCC recurrence risk following DAA administration. Design We pooled the data of 977 consecutive patients from 21 studies of HCV-related cirrhosis and HCC, who achieved complete radiological response after surgical/locoregional treatments and received DAAs (DAA group). Recurrence or death risk was expressed as HCC recurrence or death per 100 person-years (100PY). Propensity score-matched patients from the ITA.LI.CA. cohort (n=328) served as DAA-unexposed controls (no-DAA group). Risk factors for HCC recurrence were identified using random-effects Poisson. Results Recurrence rate and death risk per 100PY in DAA-treated patients were 20 (95% CI 13.9 to 29.8, I2=74.6%) and 5.7 (2.5 to 15.3, I2=54.3), respectively. Predictive factors for recurrence were alpha-fetoprotein logarithm (relative risk (RR)=1.11, 95% CI 1.03 to 1.19; p=0.01, per 1 log of ng/mL), HCC recurrence history pre-DAA initiation (RR=1.11, 95% CI 1.07 to 1.16; p<0.001), performance status (2 vs 0, RR=4.35, 95% CI 1.54 to 11.11; 2 vs 1, RR=3.7, 95% CI 1.3 to 11.11; p=0.01) and tumour burden pre-HCC treatment (multifocal vs solitary nodule, RR=1.75, 95% CI 1.25 to 2.43; p<0.001). No significant difference was observed in RR between the DAA-exposed and DAA-unexposed groups in propensity score-matched patients (RR=0.64, 95% CI 0.37 to 1.1; p=0.1). Conclusion Effects of DAA exposure on HCC recurrence risk remain inconclusive. Active clinical and radiological follow-up of patients with HCC after HCV eradication with DAA is justified.

Published
2022

46. A cholestatic pattern predicts major liver-related outcomes in patients with non-alcoholic fatty liver disease

Author

Fonds de Recherche du Québec, Pennisi, Grazia, Pipitone, Rosaria Maria, Cabibi, Daniela, Enea, Marco, Romero-Gómez, Manuel, Viganò, Mauro, Bugianesi, Elisabetta, Wong, Vincent W., Fracanzani, Anna Ludovica, Sebastiani, Giada, Berzigotti, Annalisa, Di Salvo, Francesca, Giannone, Antonino Giulio, La Mantia, Claudia, Lupo, Giulia, Porcasi, Rossana, Vernuccio, Federica, Zito, Rossella, Di Marco, Vito, Cammà, Calogero, Craxi, Antonio, Ledinghen, Victor de, Grimaudo, Stefania, Petta, Salvatore, Fonds de Recherche du Québec, Pennisi, Grazia, Pipitone, Rosaria Maria, Cabibi, Daniela, Enea, Marco, Romero-Gómez, Manuel, Viganò, Mauro, Bugianesi, Elisabetta, Wong, Vincent W., Fracanzani, Anna Ludovica, Sebastiani, Giada, Berzigotti, Annalisa, Di Salvo, Francesca, Giannone, Antonino Giulio, La Mantia, Claudia, Lupo, Giulia, Porcasi, Rossana, Vernuccio, Federica, Zito, Rossella, Di Marco, Vito, Cammà, Calogero, Craxi, Antonio, Ledinghen, Victor de, Grimaudo, Stefania, and Petta, Salvatore

Abstract

NAFLD patients usually have an increase in AST/ALT levels, but cholestasis can also be observed. We aimed to assess in subjects with NAFLD the impact of the (cholestatic) C pattern on the likelihood of developing major liver-related outcomes (MALO).

Published
2022

47. Mortality after transjugular intrahepatic portosystemic shunt in older adult patients with cirrhosis: A validated prediction model.

Author

Vizzutti, Francesco, Celsa, Ciro, Calvaruso, Vincenza, Enea, Marco, Battaglia, Salvatore, Turco, Laura, Senzolo, Marco, Nardelli, Silvia, Miraglia, Roberto, Roccarina, Davide, Campani, Claudia, Saltini, Dario, Caporali, Cristian, Indulti, Federica, Gitto, Stefano, Zanetto, Alberto, Di Maria, Gabriele, Bianchini, Marcello, Pecchini, Maddalena, and Aspite, Silvia

Published
2023
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48. A cholestatic pattern predicts major liver‐related outcomes in patients with non‐alcoholic fatty liver disease

Author

Pennisi, Grazia, primary, Pipitone, Rosaria Maria, additional, Cabibi, Daniela, additional, Enea, Marco, additional, Romero‐Gomez, Manuel, additional, Viganò, Mauro, additional, Bugianesi, Elisabetta, additional, Wong, Vincent Wai‐Sun, additional, Fracanzani, Anna Ludovica, additional, Sebastiani, Giada, additional, Berzigotti, Annalisa, additional, Di Salvo, Francesca, additional, Giannone, Antonino Giulio, additional, La Mantia, Claudia, additional, Lupo, Giulia, additional, Porcasi, Rossana, additional, Vernuccio, Federica, additional, Zito, Rossella, additional, Di Marco, Vito, additional, Cammà, Calogero, additional, Craxì, Antonio, additional, de Ledinghen, Victor, additional, Grimaudo, Stefania, additional, and Petta, Salvatore, additional

Published
2022
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49. A Genetic and Metabolic Staging System for Predicting the Outcome of Nonalcoholic Fatty Liver Disease

Author

Pennisi, Grazia, primary, Pipitone, Rosaria Maria, additional, Enea, Marco, additional, De Vincentis, Antonio, additional, Battaglia, Salvatore, additional, Di Marco, Vito, additional, Di Martino, Vincenzo, additional, Spatola, Federica, additional, Tavaglione, Federica, additional, Vespasiani‐Gentilucci, Umberto, additional, Zito, Rossella, additional, Romeo, Stefano, additional, Cammà, Calogero, additional, Craxì, Antonio, additional, Grimaudo, Stefania, additional, and Petta, Salvatore, additional

Published
2022
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