236 results on '"Ene D"'
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2. Activation assessment of the soil around the ESS accelerator tunnel
- Author
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Rakhno, I. L., Mokhov, N. V., Tropin, I. S., and Ene, D.
- Subjects
Physics - Accelerator Physics - Abstract
Activation of the soil surrounding the ESS accelerator tunnel calculated by the MARS15 code is presented. A detailed composition of the soil, that comprises about 30 different chemical elements, is considered. Spatial distributions of the produced activity are provided in both transverse and longitudinal direction. A realistic irradiation profile for the entire planned lifetime of the facility is used. The nuclear transmutation and decay of the produced radionuclides is calculated with the DeTra code which is a built-in tool for the MARS15 code. Radionuclide production by low-energy neutrons is calculated using the ENDF/B-VII evaluated nuclear data library. In order to estimate quality of this activation assessment, a comparison between calculated and measured activation of various foils in a similar radiation environment is presented., Comment: 20 pp. Presented at the 4th International Workshop on Accelerator Radiation Induced Activation (ARIA'17) held at the European Spallation Source (ESS) on May 22-24, 2017 in Lund, Sweden
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- 2018
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- View/download PDF
3. Anne’s Veneration as a Part of the Cult of the Saints
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Ene D-Vasilescu, Elena, Curta, Florin, Series Editor, Neville, Leonora, Series Editor, Tougher, Shaun, Series Editor, and Ene D-Vasilescu, Elena
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- 2018
- Full Text
- View/download PDF
4. Introduction
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Ene D-Vasilescu, Elena, Curta, Florin, Series Editor, Neville, Leonora, Series Editor, Tougher, Shaun, Series Editor, and Ene D-Vasilescu, Elena
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- 2018
- Full Text
- View/download PDF
5. St. Anne as the Prototype of a Saint Connected with Healing and Milk Nourishing: Introducing Various Additional Textual Sources, Including the Apocrypha
- Author
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Ene D-Vasilescu, Elena, Curta, Florin, Series Editor, Neville, Leonora, Series Editor, Tougher, Shaun, Series Editor, and Ene D-Vasilescu, Elena
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- 2018
- Full Text
- View/download PDF
6. Conclusion
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Ene D-Vasilescu, Elena, Curta, Florin, Series Editor, Neville, Leonora, Series Editor, Tougher, Shaun, Series Editor, and Ene D-Vasilescu, Elena
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- 2018
- Full Text
- View/download PDF
7. Anna Lactans/Galaktotrophousa Iconographic Motif Between the Twelfth and the Fourteenth Centuries
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Ene D-Vasilescu, Elena, Curta, Florin, Series Editor, Neville, Leonora, Series Editor, Tougher, Shaun, Series Editor, and Ene D-Vasilescu, Elena
- Published
- 2018
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- View/download PDF
8. The Bogomils and Iconography
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Ene D-Vasilescu, Elena, Curta, Florin, Series Editor, Neville, Leonora, Series Editor, Tougher, Shaun, Series Editor, and Ene D-Vasilescu, Elena
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- 2018
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9. Patristic Texts About Saint Anne’s Role as an Intercessor with Regard to the Alleviation of People’s Barrenness and Healing in General: Proliferation of Her Cult
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Ene D-Vasilescu, Elena, Curta, Florin, Series Editor, Neville, Leonora, Series Editor, Tougher, Shaun, Series Editor, and Ene D-Vasilescu, Elena
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- 2018
- Full Text
- View/download PDF
10. Other Faith Encounters and Instances of Milk Nourishment
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Ene D-Vasilescu, Elena, Curta, Florin, Series Editor, Neville, Leonora, Series Editor, Tougher, Shaun, Series Editor, and Ene D-Vasilescu, Elena
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- 2018
- Full Text
- View/download PDF
11. The Connection Between Heavenly Nurture and Biological Sustenance in the Ancient World
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Ene D-Vasilescu, Elena, Curta, Florin, Series Editor, Neville, Leonora, Series Editor, Tougher, Shaun, Series Editor, and Ene D-Vasilescu, Elena
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- 2018
- Full Text
- View/download PDF
12. The Pleasure of Child Nursing: St. Anne and the Infant Mary in Texts and Byzantine Art
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Ene D-Vasilescu, Elena and Ene D-Vasilescu, Elena, editor
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- 2018
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13. Changes in the phenomenon of icon-painting in Romania from the second half of the nineteenth century to the present day
- Author
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Ene D-Vasilescu, Elena and Ware, Kallistos
- Subjects
704.9482 ,Icon painting ,Romania - Abstract
The thesis aims to prove, on the one hand that the second half of the nineteenth century was the period of maximum deviation from the traditional Romanian style of icon-painting and, on the other hand, that the process following the Romanian Orthodox Church's Synod of 1889, in spite of the proclaimed return to a pure Byzantine style, actually has involved the coexistence of at least two main styles of painting: Eastern Mannerist of Byzantine lineage and Western Mannerist of Renaissance persuasion. In addition to this, a mixture of various elements, even in the painting of the same building, is also present, reaching sometimes the point of kitsch. As steps towards this end, my thesis discusses the way in which the tradition of the Orthodox Church regarding icon and wall-painting manifested itself throughout Romanian history, with special emphasis on the period from the second half of the nineteenth century to the present day. I investigate whether or not, and how the Romanian modern icons (still) fit into the Byzantine conception of an icon. The thesis presents the same tradition regarding the requirements of the profession of an iconographer, how they were fulfilled in the past and how they are satisfied today in Romania, in both a monastic and a secular milieu. Traditionally, in addition to their skills and artistic training, it is essential that iconographers should be deep believers, have a solid theological training, and live a very pure life. In Chapter 6 I present the answers of 27 Romanian contemporary iconographers to a 17 item questionnaire regarding the way in which they are trained and keep the canonical rules today, the techniques they use in painting and their own attitude towards their work.
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- 2005
14. Devotion to St. Anne in Texts and Images: From Byzantium to the Late European Middle Ages
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Elena Ene D-Vasilescu and Elena Ene D-Vasilescu
- Published
- 2018
15. Heavenly Sustenance in Patristic Texts and Byzantine Iconography: Nourished by the Word
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Elena Ene D-Vasilescu and Elena Ene D-Vasilescu
- Published
- 2018
16. Clear evidence for the impact of wildfire smoke on cirrus formation
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Ansmann, A., Ohneiser, K., Engelmann, R., Seifert, P., Mamouri, R., Ene, D., and Nisantzi, A.
- Abstract
From 27 October to 1 November 2020 we observed aged wildfire smoke layers from 10-11.5 km height with a multiwavelength Raman lidar at Limassol, Cyprus, continuously over 6 days. Aged smoke particles consist mainly of organic material. On all days, ice nucleation occurred just above the base of the smoke layer at temperatures around -50°C. The ice crystals grew fast and formed strong virga in clean air below the smoke layers. The observed smoke and cirrus features clearly indicates where the ice nucleation occurred. During the MOSAiC (Multidisciplinary drifting Observatory for the Study of Arctic Climate) expedition the German icebreaker Polarstern with a multiwavelength Raman lidar aboard drifted through the pack ice at latitudes from 85°-88.5°N from October 2019 to March 2020. During this period a wildfire smoke layer originating from record-breaking Siberian fires in the summer of 2019 and cirrus layers were continuously observed with the our lidar and a cloud radar of the ARM mobile facility in the upper troposphere and lower stratosphere (UTLS) from 7-17 km height. In this smoke layer, the evolution of more than 50 cirrus systems were monitored in the North Pole region within this 6-month period. We will discuss ice nucleation processes over Cyprus and the North Pole region. In the case of MOSAiC, the discussion is based on derived smoke ice nucleating particle concentrations and ice crystal number concentrations obtained from the combined lidar-radar studies., The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)
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- 2023
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17. The Validity of a Recipe against Asthma within Chapter 23 of Book XX in Pliny the Elder's the Natural History
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Dr.Elena Ene D-Vasilescu
- Published
- 2022
18. Heavenly Sustenance in Patristic Texts and Byzantine Iconography
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Ene D-Vasilescu, Elena, primary
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- 2018
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19. New Perspectives on Diagnosing Psoriatic Arthritis by Imaging Techniques
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Sarbu MI, Sarbu N, Cristea Ene D, Corche D, Baz R, Negru D, Nechita A, Fotea S, Anghel L, and Tatu AL
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psoriatic arthritis ,RC925-935 ,ultrasound ,imaging ,Diseases of the musculoskeletal system ,mri - Abstract
Mihaela Ionela Sarbu,1,* Nicolae Sarbu,2 Doriana Cristea Ene,3 Daniela Corche,3 Radu Baz,4,* Dragos Negru,5,* Aurel Nechita,1,6 Silvia Fotea,1,6 Lucretia Anghel,1,3 Alin Laurentiu Tatu7,8 1Faculty of Medicine and Pharmacy, “Dunarea de Jos” University, Galati, Romania; 2Faculty of Medicine and Pharmacy, “Dunarea de Jos” University, Al. I. Cuza No 35, Galati, Romania; 3Sf Apostol Andrei Clinical County Emergency Hospital, Galati, Romania; 4Department of Radiology and Medical Imaging, Clinical County Emergency Hospital Constanta, “Ovidius” University, Constanta, Romania; 5Department of Radiology – Imaging, University Hospital “Sf. Spiridon”, University of Medicine and Pharmacy “Grigore T. Popa”, Iasi, Romania; 6Department of Pediatrics, “Sf. Ioan” Clinical Hospital for Children, Galati, Romania; 7Faculty of Medicine and Pharmacy, Clinical Department, Medical and Pharmaceutical Research Unit/Competitive, Interdisciplinary Research Integrated Platform’, ReForm-UDJG, “Dunarea de Jos” University, Galati, Romania; 8Clinical Hospital St Parascheva of Infectious Diseases, Dermatology Department, Galati, Romania*These authors contributed equally to this workCorrespondence: Nicolae SarbuFaculty of Medicine and Pharmacy, “Dunarea de Jos” University, Al. I. Cuza No 35, Galati, RomaniaTel +40728301044Email dnsarbu@gmail.comAbstract: Psoriatic arthritis is a chronic inflammatory condition that can lead to severe functional impairment and irreversible damage. The diagnosis can be difficult in early cases where the clinical exam is often scarce. The lack of a serological biomarker can lead to a considerable delay in diagnosis. In this review, we discuss the existent imaging methods that have improved the diagnosis of psoriatic arthritis (PsA). The degree and type of musculoskeletal involvement cannot be assessed by only one imaging method. We think that a combination of methods is the best approach to evaluate both structural damage and inflammatory lesions and that ultrasound (US) could be the best tool to screen a patient when considering the diagnosis of PsA. US is an accessible, non-ionizing technique that offers information regarding active inflammation in joints, entheses, and soft tissues.Keywords: imaging, psoriatic arthritis, MRI, ultrasound
- Published
- 2021
20. The Validity of a Recipe against Asthma within Chapter 23 of Book XX in Pliny the Elder's the Natural History
- Author
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Ene D-Vasilescu, Dr.Elena, primary
- Published
- 2022
- Full Text
- View/download PDF
21. The ‘Gospel of Freedom’ or a Letter of Warning? The Use of Paul’s Epistle to the Galatians in the Byzantine Liturgy of St. John Chrysostom
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Elena Ene D-Vasilescu
- Subjects
Galatians ,St. John Chrysostom ,media_common.quotation_subject ,Philosophy ,John Chrysostom ,St. Paul ,Gospel ,Byzantine Liturgy ,lcsh:History of Greece ,lcsh:DF10-951 ,lcsh:Greek philology and language ,Apostle ,lcsh:PA201-899 ,Liturgy ,Classics ,Theology ,Byzantine architecture ,media_common - Abstract
Paul’s Epistle to the Galatians, read on important Christian feasts, can be commented on from various perspectives: as a documents about mission, about warning with regard to the difficulties concerning the life of a believer, as one about the differences between Jews and Christians, or/and as one about freedom. It seems to us that within this text the Apostle intended to emphasize especially the latest aspect. St. John Chrysostom considered this document so important that he included it in his Liturgy.
- Published
- 2019
22. Aspects of iconography in Byzantine Cappadocia
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E. Ene D-Vasilescu
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Motif (narrative) ,media_common.quotation_subject ,Novelty ,Art ,Iconography ,Fresco ,Classics ,Byzantine architecture ,media_common - Abstract
The main novelty my article brings concerns a particular iconographic motif: that known as the ‘trial by the water of reproach’. In the few cases where this is rendered, usually only Mary is presented as undergoing this test, but in Cappadocian art Joseph is also subjected to it. Additionally, to this visual topic, another one that is rarely depicted will be introduced and commented upon: that known as ‘Christ’s first bath’. I will provide a particular example: the fresco which constitutes part of the decoration that embellishes the walls of Karabaş Kilise/ ‘The Big Church’ in Soğanlı Valley, southern Cappadocia. A few images – one of them never published before – have been included within this publication.
- Published
- 2021
23. EURISOL-DS multi-MW target unit: Neutronics performance and shielding assessment, dose rate and material activation calculations for the MAFF configuration
- Author
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Romanets, Y., Bermudez, J., David, J.C., Ene, D., Goncalves, I.F., Kadi, Y., Kharoua, C., Luis, R., Negoita, F., Rocca, R., Tecchio, L., and Vaz, P.
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- 2010
- Full Text
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24. Global characterisation of the GELINA facility for high-resolution neutron time-of-flight measurements by Monte Carlo simulations
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Ene, D., Borcea, C., Kopecky, S., Mondelaers, W., Negret, A., and Plompen, A.J.M.
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- 2010
- Full Text
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25. Aspects of Iconography in Byzantine Cappadocia
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Ene D-Vasilescu, E., primary
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- 2021
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26. The church of San Marco in the eleventh century
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Ene D-Vasilescu, E
- Subjects
Iglesia de san Marcos ,Bizancio ,Emperor Henry IV ,The eleventh century ,Dominico Selv ,Dominico Selvo ,St Mark's church ,Venecia ,Byzantium ,Emperador Enrique IV ,Venice ,Siglo XI - Abstract
In 1084 the most important of the few consecrations of St Mark's church in Venice - that which solemnized the completion of its largest altar - took place. It is assumed that Doge Dominico Selvo (1071-1084) assigned Byzantine mosaicists to finish the decorative programme in time for the respective event. In part because of the beauty and the remarkable quality of the works they created, the eleventh century saw the prestige of this Venetian shrine increase. Also what in the popular imagination was the miraculous appearance of the relics of its patron saint from a pillar (either in 1084 or 1094, depending on the source employed) further augmented it. The article attempts to prove that the eleventh century was the most important period in the existence of the medieval Venetian church which much later became the cathedral San Marco. It will venture a description of this shrine not only on the basis of its similarities, claimed by most scholars, with the Apostoleion church in Constantinople, but also using information from extant documents as well as results of new scientific and archaeological discoveries, especially those published in the catalogue of the exhibition organised by its Procuratoria between July and November 2011, in Ken Dark and Ferudun Özgümüş's works, in the reports concerning the research undertaken by the British Museum, and in other sources. En 1084 tuvo lugar la más importante de las pocas consagraciones de la iglesia de San Marcos en Venecia, la que solemnizó la finalización de su altar mayor. Se supone que el dogo Dominico Selvo (1071-1084) encargó mosaicos bizantinos para terminar el programa decorativo a tiempo para el evento respectivo. En parte debido a la belleza y la notable calidad de las obras que crearon, el siglo XI vio aumentar el prestigio de este santuario veneciano. También lo que en el imaginario popular fue la aparición milagrosa de las reliquias de su santo patrón en un pilar (ya sea en 1084 o en 1094, según la fuente empleada) lo aumentó aún más. El artículo intenta demostrar que el siglo XI fue el período más importante en la existencia de la iglesia medieval veneciana, que mucho más tarde se convirtió en la catedral de San Marco. Se venturará una descripción de este santuario no solo sobre la base de sus similitudes, afirmadas por la mayoría de los eruditos, con la iglesia Apostoleion en Constantinopla, sino también utilizando información de documentos existentes, así como los resultados de nuevos descubrimientos científicos y arqueológicos, especialmente los publicados. en el catálogo de la exposición organizada por su Procuratoria entre julio y noviembre de 2011, en las obras de Ken Dark y Ferudun Özgümüş, en los informes sobre la investigación realizada por el Museo Británico, y en otras fuentes.
- Published
- 2021
27. Pseudo-Dionysius the Areopagite and Byzantine Art
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Ene D-Vasilescu, Elena, primary
- Published
- 2021
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28. In-target radioactive nuclei production rates with EURISOL single-stage target configuration
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Chabod, S. P., David, J. -Ch., Ene, D., Ridikas, D., and Thiollière, N.
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- 2010
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29. Experimental techniques for the calibration of lidar depolarization channels in EARLINET
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Belegante, L., Bravo-Aranda, J. A., Freudenthaler, V., Nicolae, D., Nemuc, A., Ene, D., Alados-Arboledas, L., Amodeo, A., Pappalardo, G., D'Amico, G., Amato, F., Engelmann, R., Baars, H., Wandinger, U., Papayannis, A., Kokkalis, P., and Pereira, S. N.
- Subjects
Atmospheric Science ,010504 meteorology & atmospheric sciences ,aerosol ,MASS ,01 natural sciences ,experimental study ,010309 optics ,RATIO ,SAHARAN DUST ,0103 physical sciences ,Depolarization ratio ,data quality ,INVERSION ,measurement method ,lcsh:TA170-171 ,uncertainty analysis ,EYJAFJALLAJOKULL ERUPTION ,lidar ,accuracy assessment ,0105 earth and related environmental sciences ,Remote sensing ,MULTIWAVELENGTH RAMAN LIDAR ,lcsh:TA715-787 ,lcsh:Earthwork. Foundations ,Depolarization ,OPTICAL-PROPERTIES ,calibration ,lcsh:Environmental engineering ,Aerosol ,AEROSOL CLASSIFICATION ,Lidar ,Environmental science ,ATHENS ,POLARIZATION LIDAR - Abstract
Particle depolarization ratio retrieved from lidar measurements are commonly used for aerosol-typing studies, microphysical inversion, or mass concentration retrievals. The particle depolarization ratio is one of the primary parameters that can differentiate several major aerosol components but only if the measurements are accurate enough. The accuracy related to the retrieval of particle depolarization ratios is the driving factor for assessing and improving the uncertainties of the depolarization products. This paper presents different depolarization calibration procedures used to improve the quality of the depolarization data. The results illustrate a significant improvement of the depolarization lidar products for all the selected lidar stations that have implemented depolarization calibration procedures. The calibrated volume and particle depolarization profiles at 532 nm show values that fall within a range that is generally accepted in the literature.
- Published
- 2018
30. 3D laser reconstructions of Buddhist temple from Ladakh
- Author
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Ene, D, primary and Rădvan, R, additional
- Published
- 2010
- Full Text
- View/download PDF
31. The ‘Gospel of Freedom’ or a Letter of Warning? The Use of Paul’s Epistle to the Galatians in the Byzantine Liturgy of St. John Chrysostom
- Author
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Ene D-Vasilescu, Elena, primary
- Published
- 2019
- Full Text
- View/download PDF
32. Anti-inflammatory and liver protective action of bioactive complex rich in glycosaminoglycans obtained from small sea fish: A3.34
- Author
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Rosoiu, N., Nita, R., Ene, D., and Olariu, L.
- Published
- 2010
33. A Gaze from the Fourth Century. Part two: the rendering of Christ in the Temple Icon of the Theotokos
- Author
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Elena Ene D-Vasilescu
- Subjects
Theotokos ,Archeology ,History ,icon, egypt, christ, mary theotokos, fourth century ad ,business.industry ,Face (sociological concept) ,Ancient history ,D51-90 ,Style (visual arts) ,Portrait ,Archaeology ,Chapel ,Medicine ,Private collection ,Icon ,Classics ,business ,computer ,CC1-960 ,Period (music) ,computer.programming_language - Abstract
In the article published in Byzantinoslavica, vol. 65, 2007 about the so-called ‘Temple icon’ in London, I argue that this piece on cloth in wax encaustic technique (now in a private collection) dates from the fourth century. In doing so I opposed the estimation of it belonging to the sixth-seventh centuries made, among others, by Robin Cormack. Within that piece I brought evidence in connection to Mary. In the current paper I provide information which refers especially to the way the infant Jesus is depicted within the icon in order to back this dating: Christ is shown wearing a tunic with purple clavi, a bulla, and an earring in the manner Roman children display in the portraits that survived from the third-fourth centuries AD. There are depictions of youngsters similar to such a rendering at Antinoopolis (c. AD 250-300) and Fayum (four century). Additionally, I add a later observation concerning the Virgin: there are communalities between the icon in the UK and the Hodegetria wood panel in the chapel of St. Francisca Romana, which has been certainly attested to the fifth century - nuclear magnetic resonance sensors have been used for such a purpose. The most striking common features are the style in which the face of Mary is depicted and the manner in which the expression of her eyes has been rendered in both icons. Moreover, the shape of Mary’s vestment around the neck and its general appearance are the same in both icons. The pieces date from the pre-iconoclastic period and were transported from the East in countries pertaining to Western Christendom: the icon in Rome by Angelo Frangipane (in the fifth or sixth century), the other one probably by merchants or Napoleon’s army (to France, from where Richard Temple and Laurence Morocco brought it to the UK).
- Published
- 2019
34. Linagliptin Effects on Heart Failure and Related Outcomes in Individuals With Type 2 Diabetes Mellitus at High Cardiovascular and Renal Risk in CARMELINA
- Author
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McGuire D, Alexander J, Johansen O, Perkovic V, Rosenstock J, Cooper M, Wanner C, Kahn S, Toto R, Zinman B, Baanstra D, Pfarr E, Schnaidt S, Meinicke T, George J, von Eynatten M, Marx N, Aizenberg D, Fiorella A, Edgardo N, Belen C, Alonso P, Walter M, Maia K, Guillermo S, Leandro B, Constanza R, Alejandra N, Melina C, Ariel I, Rodrigo C, Alvarez C, Jorge M, Gabriel C, German S, Bartolacci I, Bolobanich G, Tale T, Meritano M, Echeverria M, Gerrini S, Alvarez M, Torrijos N, Berli M, Coggiola J, Castaneda G, Rode R, Milessi R, Roude A, Bono J, Caresani J, Arias V, Westberg J, Allende G, Liberman A, Bordonava A, Almagro S, Gerbaudo C, Schiavi L, Budassi N, Cecilia M, Buncuga M, Carlos S, Osvaldo T, Mercedes S, Calella P, Agustina V, Aljandro M, Alberto D, Fiorella M, Cantero M, Cariganano M, Anadon P, Cartasegna L, Gabriela M, Fernanda A, Alberto R, Chacon C, Jazmin F, Colombo H, Coni E, Mattausch S, Thomsenhall K, della Torre M, Morandini M, Berra F, Margarita H, Commendatore V, Tedesco J, Bolzan P, Cuneo C, Narcisa G, Caputi V, Pablo S, Sandra G, Pacora F, Tinari M, Jure H, Parody M, Toranzo A, Frechtel G, Yohena S, Lovecchio S, Muller C, Martin S, Olivera C, Breyaui M, Bianchi G, Garcia C, Luciana V, Florencia F, Ruben G, Gelersztein E, Rey G, Sanchez C, Fornasari L, Di Pierro L, Giacomi G, Miguel S, Laura T, Gonzalo C, Ramon C, Glenny J, Koretzky M, Porto A, Tiberio O, Ellenberg A, Saurral R, Igarzabal C, Vilamajo O, Matkovich J, de Lapertosa S, Villagra M, Cuzziol G, de la Cruz M, Pinchetti R, Mierez M, Lopez C, Gorosito V, Gabito A, Kleiban A, Grosembacher L, Adrian P, Paula R, Javier G, Kraft F, Andres F, Krynski F, Nicolas P, Marcelo F, Alfredo F, de la Fuente R, Natalia C, Luquez H, Recuero Y, Becchetti N, Ruiz M, Costantino M, Vazquez G, Guzman C, Pelatia P, Maffei L, Sassone S, Yantorno M, Prado G, Khron B, Maldonado N, Gustavo L, Veronica V, Marino J, Elizabeth A, Alejandra C, Oscar R, Azize G, Gallardo M, Escudero M, Vargas E, Ramos H, Lucero C, Najenson M, Crocci I, Chiesa A, Nardone L, Dominguez S, Zanini A, Manghi F, Grossman M, Giudice G, Romeo A, Piskorz D, Miguel C, Susana D, Noeli U, Rosa S, Martin V, Soledad A, Virginia M, Lorena G, Prado A, Veronica L, Eduardo H, Adolfo P, Florencia W, Rista L, Scolari C, Rojas N, Bertolio V, Zarandon R, Jair S, Orlando C, Sanabria H, Ignacio D, Viviana C, Marina R, Sarjanovich R, Scaro G, Huerta C, Mana M, Gutierrez M, Dain A, Gavicola R, Sessa H, Sacripanti J, Felman R, Vilarino P, Sicer M, Lagrutta M, Sala J, Casabella T, Cecilia H, Carlos B, Vines G, Javier R, Vico M, Lanchiotti P, Martella C, Torres L, Villarino A, Molina M, Martinez J, Farias C, Bertola S, Rojas M, Guzman P, Nisi J, Martinez D, Barrionuevo M, Vita N, Lopez A, Vottero E, Giuliano M, Paron L, Vogel D, Mele P, Imposti H, Dominguez A, Zaidman C, Fernando G, Beck M, Beltrame P, Chemello D, Junior R, Abreu A, Fernandes V, Saboia J, Rodrigues L, Carvalho M, Gurgel M, Gadelha D, Ramos C, Borba V, Golbert M, Pitthan M, Golbert L, Valentini R, Canani L, Gross J, Valenti A, Sartori C, Dutra O, Azevedo E, Azevedo A, Vaz R, Vaz H, da Costa F, da Costa L, Panarotto D, Lain F, Camazzola F, Dellomea B, Rech R, Pizzato P, Nunes C, Jaeger C, Silveira D, Wagner L, Machado L, Rea R, de Bem A, Alves J, Jonasson T, Malucelli F, Betti R, Lerario A, Lisboa H, Bem J, Tres G, Tavares C, Nardi A, Pozzatto M, Backes L, Reolao J, Scariot E, Ziguer E, Baldissera D, Griz L, Antunes D, Victor F, Freire K, Barros A, Costi B, Sa M, Carneiro A, Felicio J, Felicio K, Penha P, Ferreira J, Melo F, Alves A, Souza A, Costa L, Pinheiro D, Turatti L, Augusto G, Leanca C, Santomauro A, Forti A, Sena R, Marinho A, Facanha C, de Souza K, de Souza A, de Queiroz W, Leite S, Vieira S, Gubert L, Olsen A, Piazzetta G, Fuck A, Ferreira M, Fortes J, Brandao T, Alves F, Radice E, dos Santos J, de Almeida R, Franco D, Saporito W, Eliaschewitz F, de Siqueira K, Bona R, Genestreti P, de Castro D, Visconti G, Sampaio C, Palhares F, Konigsfeld H, Alves E, 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Ocicka-Kozakiewicz A, Jurowiecki J, Stasinska T, Karczewicz-Janowska J, Jaruga J, ZytkiewiczJaruga D, Krupinska E, Pupek-Musialik D, Bogdanski P, Szulinska M, Skrypnik D, Skokowska E, Bojarska-Los M, Giermkowska-Samek M, Pirog M, Wojnowski L, Jelinska A, Gradzka M, Danyluk A, Lysek R, Sliwinska T, Podrazka-Szczepaniak A, Barney M, Tomczyk A, Necki M, Malicka J, Dudzinska M, KiszczakBochynska E, Markiewicz A, Galbas K, Paciorkowski A, Mazur S, Mazur M, Chmielowski A, Swiatek A, Sobocka B, Wis J, Jozefowska M, Kaczmarek M, Timler M, Cieplucha Z, Lazuka L, Lazuka N, Wittek A, Spyra J, Jasiel-Wojculewicz H, Stefanski A, Wierucki L, Hanczuk A, Misiura M, Szmygel K, Kolcowa O, Orlowska-Kunikowska E, Rutkowski M, Ignaszewska-Wyrzykowska A, Popenda G, Maciejewska J, Mostowy A, WojteckaGrabka M, Grazyna M, Wieslaw K, Barbara K, Kramarczuk E, Wojciech C, Jaroslaw H, Ewa B, Karas P, Agnieszka S, Hanna C, Justyna S, Piotr K, Wozniak I, Mateusz W, Katarzyna W, Jacek F, Andrzej J, Cymerman K, 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V, Camelia T, Oana P, Monia A, Onaca A, Mircea O, Mot A, Stolea V, Elena N, Barbonta D, Cristian B, Oana S, Popescu A, Madalina M, Coman A, Anca C, Constantinescu S, Mircea C, Diaconu-Sotropa M, Ene D, Pintilei E, Mihai G, Delia R, Toarba I, Simona H, Negru D, Flaminzeanu F, Iulian C, Maria-Cristina C, Doros R, Cleo S, Sorin B, Demian L, Mihai S, Raul B, Ioana A, Nicolau A, Cosmin P, Isabela G, Elena C, Ileana T, Valuyskikh E, Miroshnichenko E, Klementyeva N, Zelman O, Chumakova G, Vigel A, Leonova N, Pergaeva Y, Stefanovskaya O, Pushkareva S, Antoshkina L, Zheleznova N, Iveitsman, Barbarash O, Zvereva T, Zhuravleva E, Zavyrylina I, Usoltceva E, Savostyanova Y, Kupriyanova T, Krivoshapova K, Kondyukova N, Inozemceva A, Argunova Y, Tsyba L, Belenky D, Mariich O, Terekhova A, Tsygankova O, Kuznetsova E, Nagibovich G, Ivchenko Y, Dobronravov V, Dobronravov A, Bush M, Trofimenko I, Vishnevsky A, Zikov V, Kositsyn D, Palzman Z, Spiridonova T, Rodina N, Polozhentsev S, Mamedova L, Panov A, Abesadze I, Alugishvili M, Ivashkin V, Drapkina O, Korneeva O, Zyatenkova E, Glinkina I, Poluboyarinova I, Gurova O, Raykhman A, Vertkin A, Rodykova I, Shamaeva K, Petrovskaya T, Uzueva E, Milovanov Y, Milovanova S, Milovanova L, Markina M, Dobrosmyslov I, Markov V, Afanasiev S, Babich E, Belokopytova N, Demyanov S, Maximov A, Maximov I, Rebrova T, Shtatolkina M, Masin A, Demko A, Chuyko O, Pronina A, Charf G, Akatova E, Urlaeva I, Nikolin O, Khovaeva Y, Ermachkova L, Burdina E, Shvalb P, Suchkov I, Pshennikov A, Gryaznov S, Rymar O, Dolinskaya Y, Bahareva Y, Mustafina S, Sherbakova L, Ovsyannikova A, Bolshakova O, Polunicheva E, Dora S, Agafyina A, Yashina A, Vasilieva I, Yakhontova P, Selivanova S, Kargapoltseva O, Shilina N, Bayramova G, Sorokin I, Astamirova K, Kuchuk P, Koniushenko D, Malykh N, Dvorkin M, Krovelets T, Konovalova K, Seeber M, van Niekerk F, Siebert H, Steenkamp W, Wiid S, Noeth M, Siebert R, Breedt J, Bouwer J, Kapp C, Venter T, Rayner B, Trinder Y, Rheeder P, Delport E, Mathijs S, Soma P, van Zyl D, Strydom M, Marais A, Badat A, Hansa S, Fourie D, Walton T, Engelbrecht J, Jansen J, Roos J, du Toit S, Lehloenya K, van Zyl L, van Zyl F, Naude M, Mookadam M, van der Merwe A, Trokis J, Lombard L, Coetzee K, Ismail S, Bruning H, Latiff G, Yasmin O, Pillay T, Mohamed Z, Dawood S, Stapelberg A, Abrahams P, Jurgens J, van Heerden P, Swart E, Botha C, Meeding J, Hemus A, Oosthuysen W, Visagie G, Fourie N, Hutton P, van der Merwe N, Chelin N, Everton T, Duki M, Ghila N, Joshi M, Hira M, Madueno F, Martinez B, Sebastian N, Mercadal L, Isbert S, Gonzalez I, Asencio J, Figueras M, Rivas M, Garcia H, Fusalba A, Geat D, Cambra G, Sastre J, Castro F, Mas A, Portillo C, Serrano I, Hernandez S, Fajardo F, Juan C, Ferrer J, Peralta F, Padin C, Mauricio D, Madorell B, San Miguel F, Pedrol N, Trescoli C, Montanana C, Gonzalo M, Capellan J, Estrella A, Martinez C, Montesinos I, Loscos A, Coronado J, Perez J, Castillo B, Alonso C, Quesada V, Teruel J, Perez S, Lama M, del Rio E, Zlova T, Ponomarenko K, Karpenko O, Bezuglova S, Mitskevych L, Kizim S, Nevolina I, Katerenchuk V, Liudmyla B, Ivan K, Rudyk I, Olena M, Anna I, Ganna B, Topchii I, Semenovykh P, Yulia Y, Mykhalchyshyn G, Kirienko D, Kobiliak N, Bodnar, Mykhalchyshyn, Pertseva N, Olena G, Tomashkevych H, Korpachev V, Prybyla O, Kovalchuk A, Kushnarova N, Zinych O, Tseluyko V, Andriy Z, Olga R, Mankovskyy B, Zherdova N, Lykhoshapko O, Logoida P, Godlevska O, Olena V, Olga C, Gyrina O, Alifer O, Dozhuk K, Pekhenko V, Gorobets N, Korneichuk A, Makarenko E, Martynyuk L, Martynuyk O, Stanislavchuk M, Larysa P, Natalia S, Botsyurko V, Kostitska I, Dzeman O, Ablitsov Y, Ivaseiko S, Konovart O, Sandurska S, Vendzilovych Y, Samoylov O, Iryna C, Rozhkivska L, Ulyanchenko I, Kateryna V, Orlenko V, Ivaskina K, Tronko M, Tronko K, Pashkovska N, Stankova N, Vynnychenko L, Bolotnikova N, Demokhova N, Reshotko D, Popova A, Dr Bogdana, Tetiana S, Svitlana D, Oksana R, Vlasenko M, Litvinova S, 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Satyavolu S, Dev D, Yalamanchili H, Sumeyye C, Fernandes H, Chaleff F, Jancko M, Trenche S, Kaplan W, Wilcox S, Goisse M, Rua M, Black J, Chapman K, Suh D, Yan L, Song D, Chanara S, Houchin V, McKeinness A, Sotolongo R, Gutierrez K, Miranda-Palma B, Solano M, Jain M, Needell J, Banerjee A, Jarratt M, Hantel S, Lees K, Welty F, Freedman S, Parhofer K, Birkeland K, McGill J, Tijssen J, Clemmensen P, Pehrson S, Grande P, Januzzi J, Wood M, Petrie M, Sairanen T, Tatlisumak T, Soinne L, Kase C, Turan T, Mann J, Agarwal R, Fogarty D, Navaneethan S, Srinivas T, Forsmark C, Frossard J, Gelrud A, Mayerle J, Lee R, Heist R, Sullivan R, Buchbinder E, Chodak G, Edelman M, Thompson V, Coles A, and CARMELINA Investigators
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cardiovascular disease ,type 2 diabetes mellitus ,heart failure ,chronic kidney diseases - Abstract
Background: Individuals with type 2 diabetes mellitus are at increased risk for heart failure (HF), particularly those with coexisting atherosclerotic cardiovascular disease and/or kidney disease. Some but not all dipeptidyl peptidase-4 inhibitors have been associated with increased HF risk. We performed secondary analyses of HF and related outcomes with the dipeptidyl peptidase-4 inhibitor linagliptin versus placebo in CARMELINA (The Cardiovascular and Renal Microvascular Outcome Study With Linagliptin), a cardiovascular outcomes trial that enrolled participants with type 2 diabetes mellitus and atherosclerotic cardiovascular disease and/or kidney disease. Methods: Participants in 27 countries with type 2 diabetes mellitus and concomitant atherosclerotic cardiovascular disease and/or kidney disease were randomized 1:1 to receive once daily oral linagliptin 5 mg or placebo, on top of standard of care. All hospitalization for HF (hHF), cardiovascular outcomes, and deaths were prospectively captured and centrally adjudicated. In prespecified and post hoc analyses of HF and related events, Cox proportional hazards models adjusting for region and baseline history of HF were used. Recurrent hHF events were analyzed using a negative binomial model. In a subset of participants with left ventricular ejection fraction captured within the year before randomization, HF-related outcomes were assessed in subgroups stratified by left ventricular ejection fraction > or 50%. Results: CARMELINA enrolled 6979 participants (mean age, 65.9 years; estimated glomerular filtration rate, mL/min per 1.73m(2); hemoglobin A1c, 8.0%; 62.9% men; diabetes mellitus duration, 14.8 years), including 1873 (26.8%) with a history of HF at baseline. Median follow-up was 2.2 years. Linagliptin versus placebo did not affect the incidence of hHF (209/3494 [6.0%] versus 226/3485 [6.5%], respectively; hazard ratio [HR], 0.90; 95% CI, 0.74-1.08), the composite of cardiovascular death/hHF (HR, 0.94; 95% CI, 0.82-1.08), or risk for recurrent hHF events (326 versus 359 events, respectively; rate ratio, 0.94; 95% CI, 0.75-1.20). There was no heterogeneity of linagliptin effects on hHF by history of HF at baseline, baseline estimated glomerular filtration rate or urine albumin-creatinine ratio, or prerandomization left ventricular ejection fraction. Conclusions: In a large, international cardiovascular outcome trial in participants with type 2 diabetes mellitus and concomitant atherosclerotic cardiovascular disease and/or kidney disease, linagliptin did not affect the risk of hHF or other selected HF-related outcomes, including among participants with and without a history of HF, across the spectrum of kidney disease, and independent of previous left ventricular ejection fraction. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01897532.
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- 2019
35. Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk The CARMELINA Randomized Clinical Trial
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Feldman D, Fujino Y, Kitamura H, Toriumi Y, Ishiguro H, Naganuma T, Shu S, Suzuki K, Hirota Y, Hayashi T, Hozawa K, Fukui T, Abe Y, Yamauchi K, Maruyama M, Matsumura S, Kozuma R, Nagai Y, Kihara Y, Maeda H, Nakanishi K, Iitsuka T, Hatori M, Shinozaki Y, Akiyama D, Kawabe M, Takei M, Sato A, Kawai Y, Kitajima K, Ide M, Sato N, Morisaki H, Nakashima K, Takayanagi H, Watanabe H, Iwahashi N, Tsujimoto M, Hibuse K, Hata T, Ueno K, Tatsuma H, Wakida Y, Ito T, Mizuno R, Fujita H, Konishi N, Kanehira T, Watanabe R, Miyaoka H, Okada T, Yamamoto M, Okita S, Murakami H, Todo Y, Umeoka F, Hori K, Shiraishi K, Tada F, Shimizu T, Tamai J, Sasaki C, Okuzima Y, Yasuda M, Iwaita Y, Tanaka K, Rha S, Na J, Cho D, Cho Y, Hwang E, Choi T, Won K, Kim H, Kim S, Oh D, Lee J, Choi H, Chung H, Park H, Suh Y, Kim Y, Kim N, Kim K, An J, Kim J, Park K, Kwak S, Kim M, Hwangbo Y, Lee D, Hong A, Kim L, Oh C, Moon S, Jung C, Jin J, Hyun B, Yang Y, Kong S, Yoon K, Yang H, Hong T, Oh J, Park J, Lee H, Choi J, Ahn J, Han S, Park W, Jo S, Suh S, An W, Park M, Lee S, Kim D, Jin H, Seo J, Chung C, Lim J, Huh J, Park I, Yu S, Sim N, Khan S, Albakari N, Sivaraman J, Manaf K, Maharuddin I, Nagendram S, Ali N, Abdul Latiff N, Othman N, Sarip S, Chew E, Mohamed S, Aziz N, Hui K, Lin L, Velaiutham S, Khir A, Lee L, Manikam S, Chooi K, Chang M, Ooi C, Anthony J, Seganathirajah M, Ng O, Ismail N, Cheah C, Ramanathan G, Mui N, Wen F, Choo T, Bin Ruhani A, Jamaludin S, Abidin S, Nor F, Abu Hassan M, Hanari N, Ahmad N, Suan M, Zainul N, Ali S, Sridhar G, Han C, Chin A, Vin L, Kadir K, Zain A, Hussain N, Pusparajah P, Lozano F, Gomez A, Zaccari E, Vigil A, Preciado C, de Leon M, Parra M, Cervantes A, Aguirre E, Orozco E, Gonzalez S, Elizondo R, Flores E, Guerrero M, Flores F, Sanchez J, Perez F, Rodriguez J, Martinez L, Marquez D, Gutierrez B, Flores M, Real M, Campos P, Garcia P, Rios M, Romero E, Perez Z, Tarabay C, Munoz L, Farias J, Gonzalez J, Palestino N, Sanchez L, Carrillo G, Ordonez N, Pech C, Andrade M, Euan J, Ortegon M, Garcia S, Orozco J, Vazquez H, Herrera R, Perez E, Arango A, Ibarra M, Gonzales L, Esperano J, Quintana L, Salazar I, Ruiz L, Barron C, Ballesteros C, Cervera L, Hercilla E, Gomez H, Mesa J, Herrera P, Rodriguez M, Ochoa R, Mora E, Charles C, Silva R, Mijangos J, Diaz C, Zavala C, Baron P, Bernal A, Martinez F, Tlapale M, Ramirez E, Basila A, Munguia R, Tello M, Martinez M, Mulder H, van der Graaff P, Nawaz A, Keller I, Schoofs M, Smak-Gregoor P, Al-Windy N, Bulut S, de Jong J, Maas A, Schaardenburgh P, Imholz B, Heijster J, Hoogenberg K, Smit C, Kooy A, Huvers F, Landewe-Cleuren S, Kars M, van Moorsel D, Wolffenbuttel B, Lutgens H, Schutte E, Gansevoort R, Idzerda N, Westerink J, Weijmans M, Berg J, van Kleef M, Slob M, Jaspers N, Hovens M, Monajemi H, Kobielusz-Gembala I, Zmuda W, Adamczyk M, Konieczny M, Strzelecka-Sosik A, Nowacka E, Krzyzagorska E, Sekulska M, CzajkowskaKaczmarek E, Kaczmarek B, Opawska K, Dabrowska M, Kus W, Wrzesien-Kus A, Piotrowski G, Hotlos L, Ocicka-Kozakiewicz A, Jurowiecki J, Stasinska T, Karczewicz-Janowska J, Jaruga J, ZytkiewiczJaruga D, Krupinska E, Pupek-Musialik D, Bogdanski P, Szulinska M, Skrypnik D, Skokowska E, Bojarska-Los M, Giermkowska-Samek M, Pirog M, Wojnowski L, Jelinska A, Gradzka M, Danyluk A, Lysek R, Sliwinska T, Podrazka-Szczepaniak A, Barney M, Tomczyk A, Necki M, Malicka J, Dudzinska M, KiszczakBochynska E, Markiewicz A, Galbas K, Paciorkowski A, Mazur S, Mazur M, Chmielowski A, Swiatek A, Sobocka B, Wis J, Jozefowska M, Kaczmarek M, Timler M, Cieplucha Z, Lazuka L, Lazuka N, Wittek A, Spyra J, Jasiel-Wojculewicz H, Stefanski A, Wierucki L, Hanczuk A, Misiura M, Szmygel K, Kolcowa O, Orlowska-Kunikowska E, Rutkowski M, Ignaszewska-Wyrzykowska A, Popenda G, Maciejewska J, Mostowy A, WojteckaGrabka M, Grazyna M, Wieslaw K, Barbara K, Kramarczuk E, Wojciech C, Jaroslaw H, Ewa B, Karas P, Agnieszka S, Hanna C, Justyna S, Piotr K, Wozniak I, Mateusz W, Katarzyna W, Jacek F, Andrzej J, Cymerman K, Gmytrasiewicz M, Zambrzycki J, Krysiak-Kowaluk H, Klodawska K, Klszczewski Z, Zieleniewski J, Opadczuk P, Urbanska K, Faran-Grabowska K, Szczepanik T, Siegel A, Kleczek A, Kincel K, Nowak D, Slowik-Gomulka L, Watemborska-Matuszyk G, Lampart J, Strozik-Krecichwost A, Dziewit T, Broncel M, Wojcik-Odyniec J, Jakubczyk E, Wierzbicka K, Witowicz A, Jedrych B, Korczyk P, Socik-Pojawa M, Monteiro P, Monteiro S, Mendes P, Soares F, Mendes S, Leite L, Vicente J, Santos M, Ferreira A, Alves P, Rosario F, Garrao A, Duarte L, Rogado C, Duarte R, Laginha T, Matos P, Raposo J, Mariz J, Teixeira J, Capela C, Leitao A, Cardiga R, Alface M, Augusto S, Basto L, Cunha A, Rei D, Dantas J, Verdasca I, Andrade L, Silva A, Suarez M, Dias V, Silva J, Pereira N, Goncalves M, Goncalves A, Silveira A, Sampaio A, Dias A, Diogo M, Vilaca C, Cif A, Calin T, Elena S, Crisan C, Adina S, Ramona S, Anghel V, Simona C, Turcu L, Mihaela V, Cosma D, Cristina H, Marius-Calin H, Negrisanu G, Andreea-Andrada M, Maria-Mihaela V, Camelia T, Oana P, Monia A, Onaca A, Mircea O, Mot A, Stolea V, Elena N, Barbonta D, Cristian B, Oana S, Popescu A, Madalina M, Coman A, Anca C, Constantinescu S, Mircea C, Diaconu-Sotropa M, Ene D, Pintilei E, Mihai G, Delia R, Toarba I, Simona H, Negru D, Flaminzeanu F, Iulian C, Maria-Cristina C, Doros R, Cleo S, Sorin B, Demian L, Mihai S, Raul B, Ioana A, Nicolau A, Cosmin P, Isabela G, Elena C, Ileana T, Valuyskikh E, Miroshnichenko E, Klementyeva N, Zelman O, Chumakova G, Vigel A, Leonova N, Pergaeva Y, Stefanovskaya O, Pushkareva S, Antoshkina L, Zheleznova N, Iveitsman, Barbarash O, Zvereva T, Zhuravleva E, Zavyrylina I, Usoltceva E, Savostyanova Y, Kupriyanova T, Krivoshapova K, Kondyukova N, Inozemceva A, Argunova Y, Tsyba L, Belenky D, Mariich O, Terekhova A, Tsygankova O, Kuznetsova E, Nagibovich G, Ivchenko Y, Dobronravov V, Dobronravov A, Bush M, Trofimenko I, Vishnevsky A, Zikov V, Kositsyn D, Palzman Z, Spiridonova T, Rodina N, Polozhentsev S, Mamedova L, Panov A, Abesadze I, Alugishvili M, Ivashkin V, Drapkina O, Korneeva O, Zyatenkova E, Glinkina I, Poluboyarinova I, Gurova O, Raykhman A, Vertkin A, Rodykova I, Shamaeva K, Petrovskaya T, Uzueva E, Milovanov Y, Milovanova S, Milovanova L, Markina M, Dobrosmyslov I, Markov V, Afanasiev S, Babich E, Belokopytova N, Demyanov S, Maximov A, Maximov I, Rebrova T, Shtatolkina M, Masin A, Demko A, Chuyko O, Pronina A, Charf G, Akatova E, Urlaeva I, Nikolin O, Khovaeva Y, Ermachkova L, Burdina E, Shvalb P, Suchkov I, Pshennikov A, Gryaznov S, Rymar O, Dolinskaya Y, Bahareva Y, Mustafina S, Sherbakova L, Ovsyannikova A, Bolshakova O, Polunicheva E, Dora S, Agafyina A, Yashina A, Vasilieva I, Yakhontova P, Selivanova S, Kargapoltseva O, Shilina N, Bayramova G, Sorokin I, Astamirova K, Kuchuk P, Koniushenko D, Malykh N, Dvorkin M, Krovelets T, Konovalova K, Seeber M, van Niekerk F, Siebert H, Steenkamp W, Wiid S, Noeth M, Siebert R, Breedt J, Bouwer J, Kapp C, Venter T, Rayner B, Trinder Y, Rheeder P, Delport E, Mathijs S, Soma P, van Zyl D, Strydom M, Marais A, Badat A, Hansa S, Fourie D, Walton T, Engelbrecht J, Jansen J, Roos J, du Toit S, Lehloenya K, van Zyl L, van Zyl F, Naude M, Mookadam M, van der Merwe A, Trokis J, Lombard L, Coetzee K, Ismail S, Bruning H, Latiff G, Yasmin O, Pillay T, Mohamed Z, Dawood S, Stapelberg A, Abrahams P, Jurgens J, van Heerden P, Swart E, Botha C, Meeding J, Hemus A, Oosthuysen W, Visagie G, Fourie N, Hutton P, van der Merwe N, Chelin N, Everton T, Duki M, Ghila N, Joshi M, Hira M, Madueno F, Martinez B, Sebastian N, Mercadal L, Isbert S, Gonzalez I, Asencio J, Figueras M, Rivas M, Garcia H, Fusalba A, Geat D, Cambra G, Sastre J, Castro F, Mas A, Portillo C, Serrano I, Hernandez S, Fajardo F, Juan C, Ferrer J, Peralta F, Padin C, Mauricio D, Madorell B, San Miguel F, Pedrol N, Trescoli C, Montanana C, Gonzalo M, Capellan J, Estrella A, Martinez C, Montesinos I, Loscos A, Coronado J, Perez J, Castillo B, Alonso C, Quesada V, Teruel J, Perez S, Lama M, del Rio E, Zlova T, Ponomarenko K, Karpenko O, Bezuglova S, Mitskevych L, Kizim S, Nevolina I, Katerenchuk V, Liudmyla B, Ivan K, Rudyk I, Olena M, Anna I, Ganna B, Topchii I, Semenovykh P, Yulia Y, Mykhalchyshyn G, Kirienko D, Kobiliak N, Bodnar, Mykhalchyshyn, Pertseva N, Olena G, Tomashkevych H, Korpachev V, Prybyla O, Kovalchuk A, Kushnarova N, Zinych O, Tseluyko V, Andriy Z, Olga R, Mankovskyy B, Zherdova N, Lykhoshapko O, Logoida P, Godlevska O, Olena V, Olga C, Gyrina O, Alifer O, Dozhuk K, Pekhenko V, Gorobets N, Korneichuk A, Makarenko E, Martynyuk L, Martynuyk O, Stanislavchuk M, Larysa P, Natalia S, Botsyurko V, Kostitska I, Dzeman O, Ablitsov Y, Ivaseiko S, Konovart O, Sandurska S, Vendzilovych Y, Samoylov O, Iryna C, Rozhkivska L, Ulyanchenko I, Kateryna V, Orlenko V, Ivaskina K, Tronko M, Tronko K, Pashkovska N, Stankova N, Vynnychenko L, Bolotnikova N, Demokhova N, Reshotko D, Popova A, Dr Bogdana, Tetiana S, Svitlana D, Oksana R, Vlasenko M, Litvinova S, Semenyuk I, Fishchuk O, Mostovoy Y, Tkachenko T, Ovcharuk M, Rasputina L, Vakaliuk I, Tymochko N, Drapchak I, Petrovska L, Lai W, Yen H, Voon W, Lin T, Cheng K, Chiu C, Chu C, Hsu P, Chiang C, Li Y, Kuo C, Lin S, Chao T, Yu W, Sung S, Wang K, Lu T, Shih K, Wu C, Chiang F, Hwang J, Tsai C, Juang J, Jeng J, Tang S, Lai C, Cheng C, Hsieh I, Hsieh M, Chen C, Lee C, Pai P, Ko P, Wang T, Chen T, Wu H, Chang S, Chen K, Hsieh L, Chou C, Jiang J, Lee M, Huang J, Chen J, Chiu K, Tsai L, Chen P, Saxena M, Collier D, Vaidya B, Harman S, Ramell M, Davies M, Chatterjee S, Meakin L, Quinn M, Bain S, Mallipedhi A, Min T, Bashir J, Blagden M, Ali J, McCrimmon R, Brennan G, Malcolm E, McDonald D, Pearson E, Illsley G, Darzy K, Winocour P, Hanif W, Cockwell P, Charlton M, Thekkepat S, Howat I, Devers M, Patrick J, Wyatt N, Smith C, Singh B, Nicholas J, Gillani S, Green F, Bell E, Boyle J, MacKin S, Livingstone R, Arif A, Syed M, Hammoud J, Sparks J, Anderson M, Tumey R, Condit J, Reddy M, Abalos-Galito M, Rebecca J, Barker T, Seaton B, Campbell E, Kompanik H, Jayson L, Huffman C, Bialow M, McDonnell G, McCaffrey J, Manis C, DeLuca E, Levins J, Bartlett M, Anorga K, Franco M, Gentry P, Hodge D, Pohil R, Rschultz, Leggett R, Blair L, Gisler J, Niegos F, Osburn M, Parma K, Schendel S, Stines L, Winnie M, Wu P, Canales J, Yu J, Cornett G, Beavins J, Hyde D, Zapinski D, Johnson T, Levinson D, Ahmed A, Kenny B, Kuehl A, Bates C, Jantzi C, Ananthula P, Shafer J, Louthan J, Bays A, Stapleton A, Staton P, Strum D, Taylor P, Smith A, Rapp R, Bao S, Randolph C, MacGillivray B, Schuster R, Harden T, Barnella C, Dunnam T, Whiles R, Bolick C, Brockmyre A, Plucker S, Marshall C, Poteet C, Morin D, Tavel E, Averill N, McFann A, Purcell D, Dixon T, Corey E, Goss J, Drescher R, Irfan M, Naeem M, Egelhof R, Mehta P, Koehler T, Walia J, Fernandez J, Bedel G, Preet R, Bhuchar S, Ahmed F, Onyema D, Benchabbat A, Kohanbash L, Miller P, Lalinde M, Carrithers E, Patterson R, Raube-Miceli A, Martinez A, Harris B, Levy R, Siev E, Berlin H, DiMattia M, Sugimoto D, Dugas J, Benson M, Stegemoller R, Schmoll M, Kinnaman S, O'Connor T, Powel T, Rudolph L, Lewiecki M, Best E, Chavez J, Garcia M, Cohen R, Colman D, Ocampo M, Heaney L, Rappley G, Quezada I, Santos V, Nikfarjam A, Reyes M, Rodriguez R, Josephs L, Hernandez R, Flores P, Espinoza L, Mejia W, Pedraza Z, Castaneda R, Laguerre J, Cook R, Patel R, Werner H, Blank R, Small S, Andersen J, Holmes D, Farmer M, Wiener V, Pharr W, Bray B, Beekman J, Anderson A, Andrawis N, Gabra N, Moche T, Marty S, Galvez O, Reyes R, Garcia R, Lerma G, Pliquin B, Mayfield R, Durham N, Phillips R, Baran A, Kondo N, Dempsey S, Kufs W, Laddis T, Zimmer K, Van Depol M, Dweck L, Kestler M, Werner N, Ashraf M, Quick A, Schallert G, Sligh T, Trueba P, Batista J, Martinez T, Moya J, Amarales V, Santos E, Torres P, Diaz T, Diaz J, Hodish I, Else T, Buras E, Moratis A, Valika S, Rahman A, Malalis W, Box E, Box P, Kerwood B, Nagaeva J, Metz C, Hinnant J, Griswell D, 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Sherrod T, Krishnaswamy K, Aamir S, Giddaluri P, Guevara S, Kazmi P, Thomas P, Popeil L, Albright D, Pimentel S, Mould E, Cox M, Alderson T, Conrow J, Sandberg J, Raam S, Suresh B, Lafave J, Lorenz T, Johnston J, Fereidouni S, Mahadevan A, West R, Nelson A, Scott K, Ansari S, Khan B, Rastogi A, Saumell F, Gonzalez G, Torres E, Elias R, Hart T, Lozano J, Gudavilla G, Savin V, Khan A, Wiegmann T, Goel A, Gomes M, Fernandez-Gonzalez M, Gustavo F, Ivan C, Chiong R, Llerena S, Jimenez M, Oram D, George D, Lewis J, Kiefer J, Dollman A, Edje L, Pastor F, Kandath D, Lorch D, Graves A, Powell R, Hooker T, Shah S, Gomez N, Miranda F, Rosales J, Bayona I, Gomez Y, Guedes R, Rodriguez Y, Wahlen J, Jonathan W, Spencer H, Michael W, Kumar U, Govindariju K, Ordonez S, Aguirre H, Sulur P, Agarwal N, Peters L, Kaviani B, Fomenko O, Firek A, Loreen W, Ronald F, Olha F, Parrillo J, Janovitz R, Hutchinson R, Delgado E, Ashley A, Robinson S, Barbel-Johnson K, Timothy L, William C, Al-Karadsheh A, Hooper L, Suarez J, Perez D, Guerrero V, Tung D, Loo C, Sodolak K, Michaelis C, Jackson R, Covington D, Wise J, Tran T, Messina T, Torres D, Falcone J, Barettella M, Patel K, Ribo A, Mattews T, Amendolare D, McGeehan J, Corder C, Black C, Hearne S, Bounds C, Cinderella J, Etherton J, Kiem S, Treuth M, Burke B, Tivikaran V, Howard S, Miller C, Neff H, Giullian J, Mcrae J, Surratt D, Phillips J, Kretchmar J, Valdes M, Cruz J, Navarro E, Zewail A, Tai-Chi-Kwo, Stevens J, Diane S, Kim T, Gregory L, Neal S, William S, Sangrigoli R, Gejer E, Stoller S, Jeffrey D, Colar S, Kenneth W, Farris N, Mooney S, Jamal A, Nitin B, Syed R, Andrew Y, Christopher W, Abid R, Claudio G, Mojtaba M, Amna R, Michael B, Vincent T, Cherlin R, Ashton R, Pudi K, Julian W, Stephen K, Ronald A, Frias J, Kelly S, Hsia S, Clemens P, Cara H, Farley B, Raible L, Oliveros O, Hafeez H, Pecci P, Bagga-Malhotra S, Reza R, Jamal M, Mulgado M, Guevara A, Vela M, Ochoa H, Melliza T, Pena G, Awua-Larbi S, Shafi M, Alausa T, Polster S, Earl J, McNeill R, Farrington C, Carr K, Nabat M, Matthew S, Yvette E, Handelsman Y, Delkhah S, Ismail Y, Janna C, Akhtar A, Neiman A, Blumenthal S, Colleen V, Schmidt D, Ashraf E, Bhargava A, Khoo T, Langel C, Theuma P, Wright D, Fitzgerald K, Hitchcock J, Capasso-Gulve E, Wolff E, Umpierrez G, Priyathama V, Francisco P, Dawn S, Quraishi A, Kahn B, Ferro F, Hertz B, Phelps J, Campbell A, Downing J, Pangtay D, Pangatay S, Villagran-Solis K, Haseeb M, Rettig K, Kwan R, Cox R, Slimak V, So A, Schmedtje J, Chang A, Douglas Z, McGarity W, Jestel J, Kanade P, Julie J, Asher R, Canaan Y, Perez A, Alonso I, Cutchin R, Koser A, Adeola Y, Brito S, Stocks J, Frandsen B, Weigelt M, Stehouwer E, Ince C, Stephen P, Shadi B, Jeffrey C, Thethi T, Carpio G, McDuffie R, Moreau C, Stell C, Katalenich B, McKendall-Lewis C, Htun W, Conroy K, Lovre D, Galagan R, Olmeda C, Sihota A, Barton A, Beasley R, Nankivel P, Aberle M, Machin I, Porras J, Rodriguez D, Albornoz A, Haidar A, Lopez-Santini R, Rivero G, Robins G, Colyar L, Hutchins C, Sturm D, Hart K, Phillips T, Montgomery C, Albrecht W, Fehlis K, Overman D, Box M, Villarreal-Martinez D, David-Svatek D, Ajani D, Shaikh Z, Wheeler K, Brown M, Ghosh C, Bandukwala I, Kleber S, Madden J, Bishara M, Perry K, Paoli-Bruno J, Abreu E, Espiritu R, Zmeili O, Christensen T, Grubb S, Beloff S, Caugh A, van Dijk C, Yalavarthy R, DeGraauw J, Fabian S, Gillum D, Corrigan G, Singh H, Jensen K, DeMore S, Montague T, Zieve F, Levy J, Fredrickson S, Tarkington P, Chapla P, Salacata A, Walls U, Iyer R, Nguyen K, Lettman J, Appleman B, Safavie F, Scaliem L, Eder F, Maklad S, Schlaen B, Molstead J, Hartwell J, Hubish D, Little R, Rando K, Kelly R, Drury M, Young P, Wininger S, Harman A, Daza R, Robbin S, Sanchez M, Rivera I, Garcia-Estrada M, Iglesias N, Dobs A, Andrade A, Falkowski S, Parrott T, Koon A, Wood T, Burkett E, Chavous K, Gupta A, Estes C, Loud D, Rhodes S, Chen M, Bromley L, Palma R, Kattan D, Kirk U, Tatu H, Stamatin R, Lupea S, Frasie M, Colfer H, Kane L, Teklinski A, Gadowski G, Levanovich P, Saba F, Confident L, Hossain S, Steinberg B, Philippe B, Choroenthkongtrakal S, Boccalano F, Anand R, Syam V, Manohar A, Suresh P, Madhusudhan P, Patel P, Cambier P, Klonaris J, Cheng W, Fisher S, Schelle M, Reese L, McLean S, Poock J, Hoens J, Rosie A, Welshons R, Dean J, Kuhlman P, Luke R, Lohrbauer L, Cunningham M, Buday P, Lehmann M, Chrzanowski K, Fletcher A, Hargrove J, Harris F, Debs-Perez G, Maiquez A, Cordoves L, Georgescu M, Tayoun H, Munoz F, Ortiz D, Munoz G, Hamzeh I, Misra A, Zhang L, Forgosh L, Loria K, Roncari C, Hommerding J, Morris G, Lebron C, Blake K, LaVenture K, Lange C, Levinson L, Baungarten T, Edevante S, Shawley S, Moyer H, Elliott K, Iachini K, Rajan R, Davis C, Shattuck A, Simon W, Lakin G, Secrist N, Buth D, Steere D, Talbot K, Singh N, Mascolo R, Sloan S, Kmetzo J, Brown J, Carter L, Lawrence M, Arauz-Pacheco C, Lender D, Kozlow W, Cavanaugh L, Wilson J, Gujja P, Akhter F, Khan M, Mohammed A, Satyavolu S, Dev D, Yalamanchili H, Sumeyye C, Fernandes H, Chaleff F, Jancko M, Trenche S, Kaplan W, Wilcox S, Goisse M, Rua M, Black J, Chapman K, Suh D, Yan L, Song D, Chanara S, Houchin V, McKeinness A, Sotolongo R, Gutierrez K, Miranda-Palma B, Solano M, Jain M, Needell J, Banerjee A, Jarratt M, Hantel S, Lees K, Welty F, Freedman S, Parhofer K, Birkeland K, McGill J, Tijssen J, Clemmensen P, Pehrson S, Grande P, Januzzi J, Wood M, Petrie M, Sairanen T, Tatlisumak T, Soinne L, Kase C, Turan T, Mann J, Agarwal R, Fogarty D, Navaneethan S, Srinivas T, Forsmark C, Frossard J, Gelrud A, Mayerle J, Lee R, Heist R, Sullivan R, Buchbinder E, Chodak G, Edelman M, Thompson V, Coles A, and CARMELINA Investigators
- Abstract
IMPORTANCE Type 2 diabetes is associated with increased cardiovascular (CV) risk. Prior trials have demonstrated CV safety of 3 dipeptidyl peptidase 4 (DPP-4) inhibitors but have included limited numbers of patients with high CV risk and chronic kidney disease. OBJECTIVE To evaluate the effect of linagliptin, a selective DPP-4 inhibitor, on CV outcomes and kidney outcomes in patients with type 2 diabetes at high risk of CV and kidney events. DESIGN, SETTING, AND PARTICIPANTS Randomized, placebo-controlled, multicenter noninferiority trial conducted from August 2013 to August 2016 at 605 clinic sites in 27 countries among adults with type 2 diabetes, hemoglobin A(1c) of 6.5% to 10.0%, high CV risk (history of vascular disease and urine-albumin creatinine ratio [UACR] > 200mg/g), and high renal risk (reduced eGFR and micro-or macroalbuminuria). Participants with end-stage renal disease (ESRD) were excluded. Final follow-up occurred on January 18, 2018. INTERVENTIONS Patients were randomized to receive linagliptin, 5 mg once daily (n = 3494), or placebo once daily (n = 3485) added to usual care. Other glucose-lowering medications or insulin could be added based on clinical need and local clinical guidelines. MAIN OUTCOMES AND MEASURES Primary outcomewas time to first occurrence of the composite of CV death, nonfatalmyocardial infarction, or nonfatal stroke. Criteria for noninferiority of linagliptin vs placebo was defined by the upper limit of the 2-sided 95% CI for the hazard ratio (HR) of linagliptin relative to placebo being less than 1.3. Secondary outcome was time to first occurrence of adjudicated death due to renal failure, ESRD, or sustained 40% or higher decrease in eGFR from baseline. RESULTS Of 6991 enrollees, 6979 (mean age, 65.9 years; eGFR, 54.6 mL/min/1.73m2; 80.1% with UACR > 30mg/g) received at least 1 dose of study medication and 98.7% completed the study. During a median follow-up of 2.2 years, the primary outcome occurred in 434 of 3494 (12.4%) and 420 of 3485 (12.1%) in the linagliptin and placebo groups, respectively, (absolute incidence rate difference, 0.13 [95% CI,-0.63 to 0.90] per 100 person-years) (HR, 1.02; 95% CI, 0.89-1.17; P
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- 2019
36. Shrines and schools in Byzantine Cappadocia
- Author
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Elena Ene D-Vasilescu
- Subjects
060303 religions & theology ,060103 classics ,History ,0601 history and archaeology ,06 humanities and the arts ,Ancient history ,0603 philosophy, ethics and religion ,Eleventh ,Byzantine architecture - Abstract
This article has two distinct sections: the first discusses churches and the second schools in Byzantine Cappadocia. Between the fifth and the eleventh centuries the churches in this province of the empire were not only the places where the liturgy was performed, but also the social and spiritual centres of villages, towns, army garrisons, monastic complexes, etc. They fulfilled the same specific functions regardless of the purpose and scale concerning the settlements in which they were located. The article provides evidence to illustrate what these functions were and, to some extent, by which means they were accomplished. It also makes some suggestions with respect to the physical appearance of schools in the area. In so doing it allows plausible generalisations regarding the layout of other educational establishments throughout the empire. As known, there has not been substantial material published on this subject in the field of Byzantine Studies and any contribution made on this topic should be welcome.
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- 2018
37. Novel dual acting molecules possessing 5-lipoxygenase enzyme inhibition and histamine H1 receptor antagonist properties
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Scannell, R. T., Arrington, M. P., Bayless, L., Cai, X., Eckman, J. B., Eckert, M., Ene, D. G., Ellis, J. L., Hussoin, S., Latham, G. M., Lewis, T. A., Libertine, L., Nicolas, J., Selig, W. M., Schwartz, C. E., Wels, B. F., Wypij, D. M., Young, M. A., and Zou, D.
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- 2004
- Full Text
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38. Twentieth Century Developments in European Icon Painting
- Author
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Elena Ene D-Vasilescu
- Subjects
Painting ,Persuasion ,Visual Arts and Performing Arts ,media_common.quotation_subject ,Religious studies ,Art ,Diaspora ,Style (visual arts) ,Continuance ,Icon ,Iconography ,computer ,Classics ,Byzantine architecture ,computer.programming_language ,media_common - Abstract
At the beginning of the 20th century in both Greece and Russian Diaspora (mainly in Paris and Prague) a renewal of iconography that was supposed to be of Byzantine persuasion took place. That happened in parallel with the continuance of traditional icon-writing. For instance, while Photius Kontoglou urged icon-painters to go back to the roots of their art, and in Prague a group worked in the “usual” Russian style, Joanna Reitlinger in Paris adopted a radically different manner of painting. A similar situation existed in Russia in the sixteenth-seventeenth centuries and in Romania in the nineteenth.
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- 2016
39. Knowledge, Language and Intellection from Origen to Gregory Nazianzen: A Selective Survey. By ANNA USACHEVA. Pp. 212. (Early Christianity in the Context of Antiquity, 18.) Bern: Peter Lang, 2017. ISBN 978 3 631 73109 3, 73111 6, and 93110 9. Hardback e49.50; e-book e49.50; ePDF e49.50
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Ene D-Vasilescu, E
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- 2018
40. The Pleasure of Child Nursing: St. Anne and the Infant Mary in Texts and Byzantine Art
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Elena Ene D-Vasilescu
- Subjects
Daughter ,media_common.quotation_subject ,Byzantine art ,Active listening ,Middle Ages ,Art ,Iconography ,Classics ,Byzantine architecture ,Family life ,media_common ,Pleasure - Abstract
After waiting for decades to become a mother there can be no doubt that Anne took great pleasure in bringing her daughter Mary up. The literature and iconography of the Byzantine Middle Ages reflect Anne’s happy and harmonious family life. Little Mary brought many joys to her parents and that becomes obvious from listening to the hymns dedicated to her and to them and from looking at the visual scenes in which she is depicted being milk-fed, caressed as well as taught to walk and read.
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- 2018
41. Conclusion
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Elena Ene D-Vasilescu
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- 2018
42. Anne’s Veneration as a Part of the Cult of the Saints
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Elena Ene D-Vasilescu
- Subjects
media_common.quotation_subject ,Veneration ,Art ,Ancient history ,Byzantine architecture ,Cult ,media_common - Abstract
This chapter treats the emergence and the dissemination of the saints’ cult and focuses on Anne’s veneration as a part of the cult of this phenomenon.
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- 2018
43. Other Faith Encounters and Instances of Milk Nourishment
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Elena Ene D-Vasilescu
- Subjects
Faith ,fluids and secretions ,History ,media_common.quotation_subject ,food and beverages ,Religious studies ,humanities ,Mysticism ,media_common - Abstract
This chapter delves into the manifestations of the same topic in the experience of the martyrs and medieval mystics. 3.1 Mystics and Milk 3.2 Martyrs and Milk
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- 2018
44. The Connection Between Heavenly Nurture and Biological Sustenance in the Ancient World
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Elena Ene D-Vasilescu
- Subjects
Church Fathers ,History ,Association (object-oriented programming) ,Sustenance ,Greeks ,Classics ,Nature versus nurture ,Connection (mathematics) - Abstract
This chapter presents the association between heavenly nurture and biological sustenance as it was conceived by the Ancient Greeks and Romans, by the Bible and the Church fathers, as well as by apocryphal literature.
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- 2018
45. The Bogomils and Iconography
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Elena Ene D-Vasilescu
- Subjects
Literature ,Nothing ,business.industry ,media_common.quotation_subject ,Depiction ,Art ,Iconography ,business ,Sect ,Connection (mathematics) ,media_common - Abstract
This chapter introduces the Bogomil sect and shows how the depiction of Anna Galaktotrophousa was a reaction to ideas propagated by its members. It points out that theological ideas have always informed iconography but that so far nothing has been written on the connection between Bogomilism and visual scenes referring to milk-nursing.
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- 2018
46. Patristic Texts About Saint Anne’s Role as an Intercessor with Regard to the Alleviation of People’s Barrenness and Healing in General: Proliferation of Her Cult
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Elena Ene D-Vasilescu
- Subjects
media_common.quotation_subject ,SAINT ,Art ,Religious studies ,Cult ,media_common - Abstract
This chapter makes known Patristic texts about St. Anne’s role as an intercessor for people at the divine court, initially in regard to barrenness and then to healing in general.
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- 2018
47. St. Anne as the Prototype of a Saint Connected with Healing and Milk Nourishing: Introducing Various Additional Textual Sources, Including the Apocrypha
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Elena Ene D-Vasilescu
- Subjects
Literature ,business.industry ,media_common.quotation_subject ,Apocrypha ,Mainstream ,SAINT ,Art ,business ,media_common - Abstract
This chapter explores various literary sources concerned with St. Anne, including apocryphal texts, particularly as they relate to the saint milk-nursing her daughter. 6.1 Selected Mainstream Christian Texts 6.2 Apocryphal Writings 6.2.1 The Protoevangelion 6.2.2 Pseudo Matthew 6.2.3 Variant Apocryphal Texts 6.3 Descriptions of Events Leading to Mary’s Birth in Apocryphal Sources 6.4 Descriptions of Anne Breastfeeding the Child Mary in Apocryphal Sources
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- 2018
48. Anna Lactans/Galaktotrophousa Iconographic Motif Between the Twelfth and the Fourteenth Centuries
- Author
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Elena Ene D-Vasilescu
- Subjects
media_common.quotation_subject ,Motif (music) ,Art ,Ancient history ,Cult ,media_common - Abstract
This chapter deals with the visual consequences of the development of the cult of St. Anne, especially along Via Egnatia between the twelfth and the fourteenth centuries.
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- 2018
49. A Gaze from the Fourth Century. Part two: the rendering of Christ in the Temple Icon of the Theotokos
- Author
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Ene D-Vasilescu, Elena, primary
- Published
- 2019
- Full Text
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50. Shrines and Schools in Byzantine Cappadocia
- Author
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Ene D-Vasilescu, Elena, primary
- Published
- 2019
- Full Text
- View/download PDF
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