1. Emerging autophagic endo-lysosomal targets in the management of Parkinson's disease.
- Author
-
Siddiqui T and Bhatt LK
- Subjects
- Humans, Animals, Endosomes metabolism, Endosomes physiology, Molecular Targeted Therapy methods, Parkinson Disease therapy, Parkinson Disease pathology, Parkinson Disease metabolism, Autophagy physiology, Lysosomes metabolism, alpha-Synuclein metabolism
- Abstract
Synucleopathies, specifically Parkinson's disease, are still incurable and available therapeutic options are scarce and symptomatic. The autophagy-lysosomal-endosomal system is an indigenous mechanism to manage the proteome. Excess/misfolded protein accumulation activates this system, which degrades the undesired proteins via lysosomes. Cells also eliminate these proteins by releasing them into the extracellular space via exosomes. However, the sutophagy-lysosomal-endosomal system becomes unfunctional in Parkinson's disease and there is accumulation and spread of pathogenic alpha-synuclein. Neuronal degeneration results Owing to pathogenic alpha-synuclein. Thus, the autophagy-lysosomal-endosomal system could be a promising target for neuroprotection. In the present review, we discuss the autophagy-lysosomal-endosomal system as an emerging target for the management of Parkinson's disease. Modulation of these targets associated with the autophagy-lysosomal-endosomal system can aid in clearing pathogenic alpha-synuclein and prevent the degeneration of neurons., (Copyright © 2023 Elsevier Masson SAS. All rights reserved.)
- Published
- 2024
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