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12,048 results on '"Endocrinologie"'

2. Feasibility, safety, and efficacy of dietary or lifestyle interventions for hypothalamic obesity: A systematic review

Author

Cancer, Endocrinologie onderzoek, Endocrinologie patientenzorg, Brain, Child Health, Van Roessel, I. M.A.A., Van Den Brink, M., Dekker, J., Ruitenburg-van Essen, B. G., Tissing, W. J.E., van Santen, H. M., Cancer, Endocrinologie onderzoek, Endocrinologie patientenzorg, Brain, Child Health, Van Roessel, I. M.A.A., Van Den Brink, M., Dekker, J., Ruitenburg-van Essen, B. G., Tissing, W. J.E., and van Santen, H. M.

Published
2024

3. Reply - Letter to the editor - YCLNU-D-24-02083

Author

Endocrinologie onderzoek, Cancer, Endocrinologie patientenzorg, Brain, Child Health, Van Roessel, I. M.A.A., Van Den Brink, M., Dekker, J., Ruitenburg-van Essen, B. G., Tissing, W. J.E., van Santen, H. M., Endocrinologie onderzoek, Cancer, Endocrinologie patientenzorg, Brain, Child Health, Van Roessel, I. M.A.A., Van Den Brink, M., Dekker, J., Ruitenburg-van Essen, B. G., Tissing, W. J.E., and van Santen, H. M.

Published
2024

5. LINE1-mediated epigenetic repression of androgen receptor transcription causes androgen insensitivity syndrome

Author

Cluster C, Endocrinologie, Child Health, Genetica Klinische Genetica, Genetica, Genetica Sectie Genoomdiagnostiek, Pozojevic, Jelena, Sivaprasad, Radhika, Laß, Joshua, Haarich, Franziska, Trinh, Joanne, Kakar, Naseebullah, Schulz, Kristin, Händler, Kristian, Verrijn Stuart, Annemarie A., Giltay, Jacques C., van Gassen, Koen L., Caliebe, Almuth, Holterhus, Paul Martin, Spielmann, Malte, Hornig, Nadine C., Cluster C, Endocrinologie, Child Health, Genetica Klinische Genetica, Genetica, Genetica Sectie Genoomdiagnostiek, Pozojevic, Jelena, Sivaprasad, Radhika, Laß, Joshua, Haarich, Franziska, Trinh, Joanne, Kakar, Naseebullah, Schulz, Kristin, Händler, Kristian, Verrijn Stuart, Annemarie A., Giltay, Jacques C., van Gassen, Koen L., Caliebe, Almuth, Holterhus, Paul Martin, Spielmann, Malte, and Hornig, Nadine C.

Published
2024

6. Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer

Author

Endocrinologie patientenzorg, Brain, Cancer, Child Health, Highfield Research Group, SCT patientenzorg, Speerpunt, Zorg en O&O, PMC Medisch specialisten, International Childhood Cancer Outcome Project participants, Endocrinologie patientenzorg, Brain, Cancer, Child Health, Highfield Research Group, SCT patientenzorg, Speerpunt, Zorg en O&O, PMC Medisch specialisten, and International Childhood Cancer Outcome Project participants

Published
2024

7. Differences in checkpoint-inhibitor-induced hypophysitis: mono- versus combination therapy induced hypophysitis

Author

MS Interne Geneeskunde, MS Medische Oncologie, Cancer, Infection & Immunity, MS Endocriene Oncologie, MS Radiologie, Brain, Circulatory Health, Endocrinologie patientenzorg, Child Health, van der Leij, Stephanie, Suijkerbuijk, Karijn P M, van den Broek, Medard F M, Valk, Gerlof D, Dankbaar, Jan Willem, van Santen, Hanneke M, MS Interne Geneeskunde, MS Medische Oncologie, Cancer, Infection & Immunity, MS Endocriene Oncologie, MS Radiologie, Brain, Circulatory Health, Endocrinologie patientenzorg, Child Health, van der Leij, Stephanie, Suijkerbuijk, Karijn P M, van den Broek, Medard F M, Valk, Gerlof D, Dankbaar, Jan Willem, and van Santen, Hanneke M

Published
2024

8. Association of physical activity and sports participation with insulin resistance and non-alcoholic fatty liver disease in people with type 1 diabetes

Author

Endocrinologie, MS Interne Geneeskunde, Epi Infectieziekten, Circulatory Health, de Vries, M., Westerink, J., Kaasjager, H. A.H., de Valk, H. W., the UCC-SMART Study Group, Endocrinologie, MS Interne Geneeskunde, Epi Infectieziekten, Circulatory Health, de Vries, M., Westerink, J., Kaasjager, H. A.H., de Valk, H. W., and the UCC-SMART Study Group

Published
2024

9. The development of fatigue after treatment for pediatric brain tumors does not differ between tumor locations

Author

P&O Programma's, Flex en UMCU-breed, Endocrinologie patientenzorg, Brain, Cancer, Child Health, Highfield Research Group, Speerpunt, Zorg en O&O, Irestorm, Elin, Schouten-van Meeteren, Antoinette Y.N., van Gorp, Marloes, Twisk, Jos W.R., van Santen, Hanneke M., Partanen, Marita, Grootenhuis, Martha A., van Litsenburg, Raphaele R.L., P&O Programma's, Flex en UMCU-breed, Endocrinologie patientenzorg, Brain, Cancer, Child Health, Highfield Research Group, Speerpunt, Zorg en O&O, Irestorm, Elin, Schouten-van Meeteren, Antoinette Y.N., van Gorp, Marloes, Twisk, Jos W.R., van Santen, Hanneke M., Partanen, Marita, Grootenhuis, Martha A., and van Litsenburg, Raphaele R.L.

Published
2024

10. A 14-year-old girl with premature ovarian insufficiency but with a positive pregnancy test

Author

Endocrinologie patientenzorg, CDL Poli WKZ, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), Pathologie Groep Van Diest, Pathologie patiënten zorg, Brain, Cancer, Child Health, Touwslager, Robbert N.H., Michel Zwaan, C., Bakker, Boudewijn, Lentjes, Eef G.W.M., Looijenga, Leendert H.J., van Santen, Hanneke M., Endocrinologie patientenzorg, CDL Poli WKZ, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), Pathologie Groep Van Diest, Pathologie patiënten zorg, Brain, Cancer, Child Health, Touwslager, Robbert N.H., Michel Zwaan, C., Bakker, Boudewijn, Lentjes, Eef G.W.M., Looijenga, Leendert H.J., and van Santen, Hanneke M.

Published
2024

11. Primary Hypothyroidism in Childhood Cancer Survivors Treated With Radiation Therapy: A PENTEC Comprehensive Review

Author

Klinische Fysica RT, Endocrinologie patientenzorg, Brain, Child Health, Cancer, Milano, Michael T, Vargo, John A, Yorke, Ellen D, Ronckers, Cécile M, Kremer, Leontien C, Chafe, Susan M J, van Santen, Hanneke M, Marks, Lawrence B, Bentzen, Søren M, Constine, Louis S, Vogelius, Ivan R, Klinische Fysica RT, Endocrinologie patientenzorg, Brain, Child Health, Cancer, Milano, Michael T, Vargo, John A, Yorke, Ellen D, Ronckers, Cécile M, Kremer, Leontien C, Chafe, Susan M J, van Santen, Hanneke M, Marks, Lawrence B, Bentzen, Søren M, Constine, Louis S, and Vogelius, Ivan R

Published
2024

12. Overview of European standard clinical practice recommendations for multidiscplinary teams involved in the treatment of central nervous system tumours in children and adolescents – SIOPE Brain Tumour Group

Author

MS Radiotherapie, Cancer, Zorgeenheid Oogheelkunde Medisch, MS Oogheelkunde, Brain, Endocrinologie patientenzorg, Child Health, Otth, Maria, Scheinemann, Katrin, Ajithkumar, Thankamma, Aquilina, Kristian, Avula, Shivaram, Gan, Hoong Wei, Janssens, Geert O., Lemiere, Jurgen, Morana, Giovanni, Opocher, Enrico, Pfister, Stefan M., Porro, Giorgio, Sahm, Felix, Thomale, Ulrich Wilhelm, van Egmond-Ebbeling, Michelle, van Santen, Hanneke M., Pizer, Barry, Rutkowski, Stefan, MS Radiotherapie, Cancer, Zorgeenheid Oogheelkunde Medisch, MS Oogheelkunde, Brain, Endocrinologie patientenzorg, Child Health, Otth, Maria, Scheinemann, Katrin, Ajithkumar, Thankamma, Aquilina, Kristian, Avula, Shivaram, Gan, Hoong Wei, Janssens, Geert O., Lemiere, Jurgen, Morana, Giovanni, Opocher, Enrico, Pfister, Stefan M., Porro, Giorgio, Sahm, Felix, Thomale, Ulrich Wilhelm, van Egmond-Ebbeling, Michelle, van Santen, Hanneke M., Pizer, Barry, and Rutkowski, Stefan

Published
2024

13. BMI increase during early childhood in boys with cystic fibrosis and early adrenarche

Author

Longziekten onderzoek 1, Longziekten patientenzorg, Speerpunt Child Health, Child Health, Infection & Immunity, Endocrinologie patientenzorg, Brain, Cancer, Tamer, Gizem, Arets, Hubertus Gerardus Maria, van der Ent, Cornelis Kors, van Santen, Hanneke Margo, van der Kamp, Hetty Jacoba, Longziekten onderzoek 1, Longziekten patientenzorg, Speerpunt Child Health, Child Health, Infection & Immunity, Endocrinologie patientenzorg, Brain, Cancer, Tamer, Gizem, Arets, Hubertus Gerardus Maria, van der Ent, Cornelis Kors, van Santen, Hanneke Margo, and van der Kamp, Hetty Jacoba

Published
2024

15. The cumulative burden of self-reported, clinically relevant outcomes in long-term childhood cancer survivors and implications for survivorship care: A DCCSS LATER study

Author

Klinische Fysica RT, Speerpunt, Zorg en O&O, Cancer, Child Health, SCT patientenzorg, Haematologie patientenzorg, Endocrinologie patientenzorg, Brain, PMC Medisch specialisten, Streefkerk, Nina, Teepen, Jop C., Feijen, Elizabeth A.M., Jóźwiak, Katarzyna, van der Pal, Helena J.H., Ronckers, Cecile M., De Vries, Andrica C.H., Van der Heiden-van Der Loo, Margriet, Hollema, Nynke, van den Berg, Marleen, Loonen, Jacqueline, Grootenhuis, Martha A., Bresters, Dorine, Versluys, A. Brigitta, van Dulmen-den Broeder, Eline, van den Heuvel-Eibrink, Marry M., van Leeuwen, Flora E., Neggers, Sebastian J.C.M.M., Van Santen, Hanneke M., Hawkins, Mike, Hauptmann, Michael, Yoneoka, Daisuke, Korevaar, Joke C., Tissing, Wim J.E., Kremer, Leontien C.M., Klinische Fysica RT, Speerpunt, Zorg en O&O, Cancer, Child Health, SCT patientenzorg, Haematologie patientenzorg, Endocrinologie patientenzorg, Brain, PMC Medisch specialisten, Streefkerk, Nina, Teepen, Jop C., Feijen, Elizabeth A.M., Jóźwiak, Katarzyna, van der Pal, Helena J.H., Ronckers, Cecile M., De Vries, Andrica C.H., Van der Heiden-van Der Loo, Margriet, Hollema, Nynke, van den Berg, Marleen, Loonen, Jacqueline, Grootenhuis, Martha A., Bresters, Dorine, Versluys, A. Brigitta, van Dulmen-den Broeder, Eline, van den Heuvel-Eibrink, Marry M., van Leeuwen, Flora E., Neggers, Sebastian J.C.M.M., Van Santen, Hanneke M., Hawkins, Mike, Hauptmann, Michael, Yoneoka, Daisuke, Korevaar, Joke C., Tissing, Wim J.E., and Kremer, Leontien C.M.

Published
2024

16. Comment peut-on expliquer l'épidémie d'obésité ?

Author

UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Thissen, Jean-Paul, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, and Thissen, Jean-Paul

Abstract

L’obésité est une maladie complexe et multifactorielle (1). Elle résulte d’une interaction entre des facteurs génétiques et environnementaux. Ceux-ci conduisent à un déséquilibre chronique entre les apports et les dépenses d’énergie, dont l’excédent s’accumule sous forme de triglycérides principalement dans le tissu adipeux (2). L’obésité résulte donc d’une altération de l’homéostasie énergétique. La prévalence de l’obésité dans le monde a doublé au cours des 40 dernières années (3). Les projections estiment que 20% de la population mondiale, soit un milliard d’individus, sera en obésité en 2025. Aucune population du globe ou tranche d’âge n’est épargnée. Cette épidémie génère de nombreuses comorbidités susceptibles de raccourcir l’espérance de vie. Elle cause parallèlement une réduction de la productivité tout en augmentant le coût des soins de santé. Cette synthèse vise à répondre à deux questions: d’une part, quelles sont les causes de cette épidémie? Et d’autre part, pourquoi seuls certains individus en sont affectés?

Published
2023

17. Cushing's Syndrome in the Elderly: Data from the European Registry on Cushing's Syndrome.

Author

UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Amodru, Vincent, Ferriere, Amandine, Tabarin, Antoine, Castinetti, Frederic, Tsagarakis, Stylianos, Toth, Miklos, Feelders, Richard A, Webb, Susan M, Reincke, Martin, Netea-Maier, Romana, Kastelan, Darko, Elenkova, Atanaska, Maiter, Dominique, Ragnarsson, Oskar, Santos, Alicia, Valassi, Elena, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Amodru, Vincent, Ferriere, Amandine, Tabarin, Antoine, Castinetti, Frederic, Tsagarakis, Stylianos, Toth, Miklos, Feelders, Richard A, Webb, Susan M, Reincke, Martin, Netea-Maier, Romana, Kastelan, Darko, Elenkova, Atanaska, Maiter, Dominique, Ragnarsson, Oskar, Santos, Alicia, and Valassi, Elena

Abstract

OBJECTIVE: To evaluate whether age-related differences exist in clinical characteristics, diagnostic approach and management strategies in patients with Cushing's syndrome included in the European Registry on Cushing's Syndrome (ERCUSYN). DESIGN: Cohort study. METHODS: We analyzed 1791 patients with CS, of whom 1234 (69%) had pituitary-dependent CS (PIT-CS), 450 (25%) adrenal-dependent CS (ADR-CS) and 107 (6%) had an ectopic source (ECT-CS). According to the WHO criteria, 1616 patients (90.2%) were classified as younger (<65 years) and 175 (9.8%) as older (>65 years). RESULTS: Older patients were more frequently males and had a lower BMI and waist circumference as compared with the younger. Older patients also had a lower prevalence of skin alterations, depression, hair loss, hirsutism and reduced libido, but a higher prevalence of muscle weakness, diabetes, hypertension, cardiovascular disease, venous thromboembolism and bone fractures than younger patients, regardless of sex (p<0.01 for all comparisons). Measurement of UFC supported the diagnosis of CS less frequently in older patients as compared with the younger (p<0.05). An extra-sellar macroadenoma (macrocorticotropinoma with extrasellar extension) was more common in older PIT-CS patients than in the younger (p<0.01). Older PIT-CS patients more frequently received cortisol-lowering medications and radiotherapy as a first-line treatment, whereas surgery was the preferred approach in the younger (p<0.01 for all comparisons). When transsphenoidal surgery was performed, the remission rate was lower in the elderly as compared with their younger counterpart (p<0.05). CONCLUSIONS: Older CS patients lack several typical symptoms of hypercortisolism, present with more comorbidities regardless of sex, and are more often conservatively treated.

Published
2023

18. Hoe kunnen we de obesitas-epidemie verklaren ?

Author

UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Thissen, Jean-Paul, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, and Thissen, Jean-Paul

Abstract

Obesitas is een complexe en multifactoriële ziekte (1). Het is het resultaat van een interactie tussen genetische en omgevingsfactoren. Deze leiden tot een chronisch gebrek aan evenwicht tussen energie-inname en -uitgave, waarbij het energieoverschot zich ophoopt in de vorm van triglyceriden, voornamelijk in het vetweefsel (2). Obesitas is dus het resultaat van een verandering in de energiehomeostase. In de afgelopen 40 jaar is de prevalentie van zwaarlijvigheid wereldwijd verdubbeld (3). Prognoses schatten dat 20% van de wereldbevolking, oftewel een miljard mensen, in 2025 zwaarlijvig zal zijn. Geen bevolking ter wereld of leeftijdsgroep wordt gespaard. Deze epidemie veroorzaakt talrijke comorbiditeiten die de levensverwachting kunnen verkorten. Tegelijkertijd veroorzaakt het een verminderde productiviteit en verhoogt het de kosten voor de gezondheidszorg. Deze synthese heeft als doel twee vragen te beantwoorden: ten eerste, wat zijn de oorzaken van deze epidemie? En ten tweede, waarom krijgen alleen bepaalde patiënten hiermee te maken?

Published
2023

19. Starting point for benchmarking outcomes and reporting of pituitary adenoma surgery within the European Reference Network on Rare Endocrine Conditions (Endo-ERN): results from a meta-analysis and survey study.

Author

UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, UCL - (SLuc) Service de neurochirurgie, Zamanipoor Najafabadi, Amir H, van der Meulen, Merel, Priego Zurita, Ana Luisa, Faisal Ahmed, S, van Furth, Wouter R, Charmandari, Evangelia, Hiort, Olaf, Pereira, Alberto M, Dattani, Mehul, Vitali, Diana, de Graaf, Johan P, Biermasz, Nienke R, MTG6 Pituitary of Endo-ERN, Maiter, Dominique, Raftopoulos, Christian, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, UCL - (SLuc) Service de neurochirurgie, Zamanipoor Najafabadi, Amir H, van der Meulen, Merel, Priego Zurita, Ana Luisa, Faisal Ahmed, S, van Furth, Wouter R, Charmandari, Evangelia, Hiort, Olaf, Pereira, Alberto M, Dattani, Mehul, Vitali, Diana, de Graaf, Johan P, Biermasz, Nienke R, MTG6 Pituitary of Endo-ERN, Maiter, Dominique, and Raftopoulos, Christian

Abstract

OBJECTIVE: The European Reference Network on Rare Endocrine Conditions (Endo-ERN) aims to organize high-quality healthcare throughout Europe, including care for pituitary adenoma patients. As surgery is the mainstay of treatment, we aimed to describe the current surgical practice and published surgical outcomes of pituitary adenoma within Endo-ERN. DESIGN AND METHODS: Systematic review and meta-analysis of studies reporting surgical outcomes of pituitary adenoma patients within Endo-ERN MTG6 pituitary reference centers between 2010 and 2019. A survey was completed by reference centers on their current surgical practice. RESULTS: A total of 18 out of 43 (42%) reference centers located in 7 of the 20 (35%) MTG6-represented countries published 48 articles. Remission rates were 50% (95% CI: 42-59) for patients with acromegaly, 68% (95% CI: 60-75) for Cushing's disease, and 53% (95% CI: 39-66%) for prolactinoma. Gross total resection was achieved in 49% (95% CI: 37-61%) of patients and visual improvement in 78% (95% CI: 68-87). Mortality, hemorrhage, and carotid injury occurred in less than 1% of patients. New-onset hypopituitarism occurred in 16% (95% CI: 11-23), transient diabetes insipidus in 12% (95% CI: 6-21), permanent diabetes insipidus in 4% (95% CI: 3-6), syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in 9% (95% CI: 5-14), severe epistaxis in 2% (95% CI: 0-4), and cerebrospinal fluid leak in 4% (95% CI: 2-6). Thirty-five (81%) centers completed the survey: 54% were operated endoscopically and 57% were together with an ENT surgeon. CONCLUSION: The results of this study could be used as a first benchmark for the outcomes of pituitary adenoma surgery within Endo-ERN. However, the heterogeneity between studies in the reporting of outcomes hampers comparability and warrants outcome collection through registries.

Published
2023

20. Elevated IGF-1 concentrations in children with low grade glioma: A descriptive analysis in a retrospective national cohort

Author

Endocrinologie onderzoek, Cancer, Child Health, Endocrinologie patientenzorg, Zorg en O&O, Brain, van Schaik, Jiska, van Roessel, Ichelle M A A, Bos, Iris D, Claashen-van der Grinten, Hedi L, Clement, Sarah C, van Iersel, Laura, Bakker, Boudewijn, Meijer, Lisethe, Kremer, Leontien, Schouten-van Meeteren, A Y Netteke, van Santen, Hanneke M, Endocrinologie onderzoek, Cancer, Child Health, Endocrinologie patientenzorg, Zorg en O&O, Brain, van Schaik, Jiska, van Roessel, Ichelle M A A, Bos, Iris D, Claashen-van der Grinten, Hedi L, Clement, Sarah C, van Iersel, Laura, Bakker, Boudewijn, Meijer, Lisethe, Kremer, Leontien, Schouten-van Meeteren, A Y Netteke, and van Santen, Hanneke M

Published
2023

21. Does Ultrasound Really Contribute to Detection of Residual/Recurrent Disease After Pediatric Thyroidectomy? Preliminary Data Supporting a 'Thyroglobulin-First' Approach

Author

Endocrinologie onderzoek, Endocrinologie patientenzorg, Brain, Cancer, Child Health, Lebbink, Chantal Anne, Van Santen, Hanneke Margo, Daneman, Alan, Wasserman, Jonathan Daniel, Endocrinologie onderzoek, Endocrinologie patientenzorg, Brain, Cancer, Child Health, Lebbink, Chantal Anne, Van Santen, Hanneke Margo, Daneman, Alan, and Wasserman, Jonathan Daniel

Published
2023

22. Safety of growth hormone replacement therapy in childhood-onset craniopharyngioma: a systematic review and cohort study

Author

Endocrinologie onderzoek, Endocrinologie patientenzorg, Neurochirurgen, Cancer, PMC Medisch specialisten, Brain, Child Health, van Schaik, Jiska, Kormelink, Eline, Kabak, Eda, van Dalen, Elvira C, Schouten-van Meeteren, Antoinette Y N, de Vos-Kerkhof, Evelien, Bakker, Boudewijn, Fiocco, Marta, Hoving, Eelco W, Tissing, Wim J E, van Santen, H M, Endocrinologie onderzoek, Endocrinologie patientenzorg, Neurochirurgen, Cancer, PMC Medisch specialisten, Brain, Child Health, van Schaik, Jiska, Kormelink, Eline, Kabak, Eda, van Dalen, Elvira C, Schouten-van Meeteren, Antoinette Y N, de Vos-Kerkhof, Evelien, Bakker, Boudewijn, Fiocco, Marta, Hoving, Eelco W, Tissing, Wim J E, and van Santen, H M

Published
2023

23. Changes in thyroid function parameters 3 months after allogeneic and autologous hematopoietic stem cell transplantation in children

Author

Endocrinologie onderzoek, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), Cluster C, Endocrinologie, Child Health, PMC Medisch specialisten, Cancer, Brain, Endocrinologie patientenzorg, Lebbink, C A, Bresters, D, Tersteeg, J P B, van den Bos, C, Dierselhuis, M P, Lentjes, E G W M, Verrijn Stuart, A A, Fiocco, M, Tissing, W J E, van Santen, H M, Endocrinologie onderzoek, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), Cluster C, Endocrinologie, Child Health, PMC Medisch specialisten, Cancer, Brain, Endocrinologie patientenzorg, Lebbink, C A, Bresters, D, Tersteeg, J P B, van den Bos, C, Dierselhuis, M P, Lentjes, E G W M, Verrijn Stuart, A A, Fiocco, M, Tissing, W J E, and van Santen, H M

Published
2023

24. Thyroid Profile in the First Three Months after Starting Treatment in Children with Newly Diagnosed Cancer

Author

Endocrinologie onderzoek, Cluster C, Endocrinologie, Child Health, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), PMC Medisch specialisten, Endocrinologie patientenzorg, Brain, Cancer, Lebbink, Chantal A, van den Bos, Cor, Dierselhuis, Miranda P, Fiocco, Marta, Verrijn Stuart, Annemarie A, Lentjes, Eef G W M, Plasschaert, Sabine L A, Tissing, Wim J E, van Santen, Hanneke M, Endocrinologie onderzoek, Cluster C, Endocrinologie, Child Health, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), PMC Medisch specialisten, Endocrinologie patientenzorg, Brain, Cancer, Lebbink, Chantal A, van den Bos, Cor, Dierselhuis, Miranda P, Fiocco, Marta, Verrijn Stuart, Annemarie A, Lentjes, Eef G W M, Plasschaert, Sabine L A, Tissing, Wim J E, and van Santen, Hanneke M

Published
2023

25. Thyroid dysfunction during treatment with systemic antineoplastic therapy for childhood cancer: a systematic review

Author

MS Interne Geneeskunde, Endocrinologie onderzoek, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), PMC Medisch specialisten, Cluster C, Endocrinologie, Child Health, Speerpunt, Zorg en O&O, Cancer, Endocrinologie patientenzorg, Brain, van der Leij, Stephanie, Lebbink, Chantal A, Lentjes, Eef Gwm, Tissing, Wim Je, Stuart, Annemarie Verrijn, van den Heuvel-Eibrink, Marry M, van Santen, Hanneke M, van Dalen, Elvira C, MS Interne Geneeskunde, Endocrinologie onderzoek, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), PMC Medisch specialisten, Cluster C, Endocrinologie, Child Health, Speerpunt, Zorg en O&O, Cancer, Endocrinologie patientenzorg, Brain, van der Leij, Stephanie, Lebbink, Chantal A, Lentjes, Eef Gwm, Tissing, Wim Je, Stuart, Annemarie Verrijn, van den Heuvel-Eibrink, Marry M, van Santen, Hanneke M, and van Dalen, Elvira C

Published
2023

26. Diagnostic criteria for the hypothalamic syndrome in childhood

Author

Cancer, Brain, Child Health, Endocrinologie patientenzorg, Endocrinologie onderzoek, van Santen, Hanneke M., van Schaik, Jiska, van Roessel, Ichelle M.A.A., Beckhaus, Julia, Boekhoff, Svenja, Müller, Hermann L., Cancer, Brain, Child Health, Endocrinologie patientenzorg, Endocrinologie onderzoek, van Santen, Hanneke M., van Schaik, Jiska, van Roessel, Ichelle M.A.A., Beckhaus, Julia, Boekhoff, Svenja, and Müller, Hermann L.

Published
2023

27. Development of a pediatric differentiated thyroid carcinoma registry within the EuRRECa project: rationale and protocol

Author

Endocrinologie onderzoek, Arts-assistenten Kinderen, CTI Van der Vlist, Cancer, Heelkunde Opleiding, MS CGO, Endocrinologie patientenzorg, Brain, Child Health, Clement, S. C., Visser, W. E., Lebbink, C. A., Albano, D., Claahsen-Van der Grinten, H. L., Czarniecka, A., Dias, R. P., Dierselhuis, M. P., Dzivite-Krisane, I., Elisei, R., Garcia-Burillo, A., Izatt, L., Kanaka-Gantenbein, C., Krude, H., Lamartina, L., Lorenz, K., Luster, M., Navardauskaitė, R., Negre Busó, M., Newbold, K., Peeters, R. P., Pellegriti, G., Piccardo, A., Priego, A. L., Redlich, A., de Sanctis, L., Sobrinho-Simões, M., van Trotsenburg, A. S.P., Verburg, F. A., Vriens, M., Links, T. P., Ahmed, S. F., van Santen, H. M., Endocrinologie onderzoek, Arts-assistenten Kinderen, CTI Van der Vlist, Cancer, Heelkunde Opleiding, MS CGO, Endocrinologie patientenzorg, Brain, Child Health, Clement, S. C., Visser, W. E., Lebbink, C. A., Albano, D., Claahsen-Van der Grinten, H. L., Czarniecka, A., Dias, R. P., Dierselhuis, M. P., Dzivite-Krisane, I., Elisei, R., Garcia-Burillo, A., Izatt, L., Kanaka-Gantenbein, C., Krude, H., Lamartina, L., Lorenz, K., Luster, M., Navardauskaitė, R., Negre Busó, M., Newbold, K., Peeters, R. P., Pellegriti, G., Piccardo, A., Priego, A. L., Redlich, A., de Sanctis, L., Sobrinho-Simões, M., van Trotsenburg, A. S.P., Verburg, F. A., Vriens, M., Links, T. P., Ahmed, S. F., and van Santen, H. M.

Published
2023

29. Effective multimodal management of a giant adrenocortical carcinoma.

Author

UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (MGD) Service d'endocrinologie, UCL - (MGD) Service de chirurgie, UCL - (MGD) Service d'oncologie médicale, UCL - (MGD) Service d'anatomie pathologique, Pairon, Camille, Dili, Alexandra, Claude, Bertrand, D'Hondt, Lionel, Fervaille, Caroline, Donckier, Julian, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (MGD) Service d'endocrinologie, UCL - (MGD) Service de chirurgie, UCL - (MGD) Service d'oncologie médicale, UCL - (MGD) Service d'anatomie pathologique, Pairon, Camille, Dili, Alexandra, Claude, Bertrand, D'Hondt, Lionel, Fervaille, Caroline, and Donckier, Julian

Abstract

Adrenocortical carcinoma is a rare and aggressive tumour. The only curative treatment is surgery with negative margins. In most series, the average lesion size ranges from 5.5 to 15 cm. We report the case of a 27-year-old female with hyperandrogenism and Cushing syndrome due to a right adrenocortical carcinoma of 19.7 cm. The tumour abutting on liver and vena cava and the presence two nodules in liver required extensive surgery including a right posterior sectionectomy and an en bloc resection of the adrenal mass together with the right kidney and the gallbladder. The vena cava was also resected with a reconstruction using a pericardial patch since it was invaded on its border. Pathological examination confirmed an adrenocortical carcinoma, with tumour invasion of vessels, tumour capsule, vena cava and two metastases in the liver (pT4N0M1). All margins were negative. Three months after surgery, two lung nodules, cardio-phrenic and internal mammary adenomegalies were noticed on a PET/CT scan, justifying the initiation of chemotherapy, alongside with mitotane. After a 10-month follow-up, CT scan was stable excepted for a lung nodule growing from 4 to 7 mm. Targeted stereotaxic radiotherapy was then administered. Twenty-two months after surgery, the patient has improved considerably and all signs of hyperandrogenism and Cushing syndrome have resolved. This case of adrenocortical carcinoma illustrates one of the largest tumours among those reported. It demonstrates the feasibility and effectiveness of a multimodal approach in its treatment even if it is giant and at high risk.

Published
2022

30. Prevalence, Characteristics, and Prognosis of Peripheral Arterial Disease in Patients With Diabetic Charcot Foot.

Author

UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - SSS/IREC/NMSK - Neuro-musculo-skeletal Lab, UCL - (SLuc) Service de radiologie, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, UCL - (SLuc) Service d'endocrinologie et de nutrition, Orioli, Laura, Hammer, Frank, Vande Berg, Bruno, Putineanu, Dan Constantin, Maiter, Dominique, Vandeleene, Bernard, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - SSS/IREC/IMAG - Pôle d'imagerie médicale, UCL - SSS/IREC/NMSK - Neuro-musculo-skeletal Lab, UCL - (SLuc) Service de radiologie, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, UCL - (SLuc) Service d'endocrinologie et de nutrition, Orioli, Laura, Hammer, Frank, Vande Berg, Bruno, Putineanu, Dan Constantin, Maiter, Dominique, and Vandeleene, Bernard

Abstract

Charcot foot (CF) is a rare complication of diabetes associated with foot deformities and foot ulcers. Peripheral arterial disease (PAD) is a factor of poor prognosis in patients with diabetic foot ulcers (DFUs). However, PAD has infrequently been studied in CF. We aimed to determine the prevalence, the characteristics and the prognosis of PAD in a large group of patients with diabetic CF. We retrospectively compared 56 patients with diabetic CF to 116 patients with diabetic foot without CF. The prevalence of PAD in patients with CF was 66.1%. Compared to patients without CF, patients with CF had similar risks to have PAD (OR 0.98, 95%CI 0.50-1.94, p= .97) and neuro-ischemic DFUs (OR 1.19, 95%CI 0.57-2.49, p= .65), more risk to have lesions of distal arteries (OR 4.17, 95%CI 1.76-9.94, p= .001) and less risk to need revascularization (OR 0.14, 95%CI 0.06-0.36, p< .001). In patients with CF, PAD was strongly predicted by DFUs (OR 24.55, 95%CI 1.80-334.43, p= .016) and coronary artery disease (OR 17.11, 95%CI 1.75-167.43, p =.015). Survival rate and limb salvage rate in patients with CF were not worsened by PAD and by neuro-ischemic DFUs, respectively. In conclusion, we show that PAD should not be overlooked in patients with diabetic CF, especially in those having DFUs or coronary artery disease. PAD in patients with CF differed from that of patients without CF since it predominated in distal arteries and required less often revascularization.

Published
2022

31. Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice

Author

UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Le Roy, Tiphaine, Moens De Hase, Emilie, Van Hul, Matthias, Paquot, Adrien, Pelicaen, Rudy, Régnier, Marion, Depommier, Clara, Druart, Céline, Everard, Amandine, Maiter, Dominique, Delzenne, Nathalie M., Bindels, Laure B., de Barsy, Marie, Loumaye, Audrey, Hermans, Michel, Thissen, Jean-Paul, Vieira-Silva, Sara, Falony, Gwen, Raes, Jeroen, Muccioli, Giulio, Cani, Patrice D., UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Le Roy, Tiphaine, Moens De Hase, Emilie, Van Hul, Matthias, Paquot, Adrien, Pelicaen, Rudy, Régnier, Marion, Depommier, Clara, Druart, Céline, Everard, Amandine, Maiter, Dominique, Delzenne, Nathalie M., Bindels, Laure B., de Barsy, Marie, Loumaye, Audrey, Hermans, Michel, Thissen, Jean-Paul, Vieira-Silva, Sara, Falony, Gwen, Raes, Jeroen, Muccioli, Giulio, and Cani, Patrice D.

Abstract

Objective: To investigate the abundance and the prevalence of Dysosmobacter welbionis J115T, a novel butyrate-producing bacterium isolated from the human gut both in the general population and in subjects with metabolic syndrome. To study the impact of this bacterium on host metabolism using diet-induced obese and diabetic mice. Design: We analysed the presence and abundance of the bacterium in 11 984 subjects using four human cohorts (ie, Human Microbiome Project, American Gut Project, Flemish Gut Flora Project and Microbes4U). Then, we tested the effects of daily oral gavages with live D. welbionis J115T on metabolism and several hallmarks of obesity, diabetes, inflammation and lipid metabolism in obese/diabetic mice. Results: This newly identified bacterium was detected in 62.7%-69.8% of the healthy population. Strikingly, in obese humans with a metabolic syndrome, the abundance of Dysosmobacter genus correlates negatively with body mass index, fasting glucose and glycated haemoglobin. In mice, supplementation with live D. welbionis J115T, but not with the pasteurised bacteria, partially counteracted diet-induced obesity development, fat mass gain, insulin resistance and white adipose tissue hypertrophy and inflammation. In addition, live D. welbionis J115T administration protected the mice from brown adipose tissue inflammation in association with increased mitochondria number and non-shivering thermogenesis. These effects occurred with minor impact on the mouse intestinal microbiota composition. Conclusions: These results suggest that D. welbionis J115T directly and beneficially influences host metabolism and is a strong candidate for the development of next-generation beneficial bacteria targeting obesity and associated metabolic diseases.

Published
2022

32. Euglycemic diabetic ketoacidosis in a patient with type 1 diabetes and SARS-CoV-2 pneumonia: case report and review of the literature.

Author

UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Oriot, Philippe, Hermans, Michel, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Oriot, Philippe, and Hermans, Michel

Abstract

OBJECTIVE: Recent publications on Coronavirus Disease-2019 (COVID-19) report that diabetic people with or without co-morbidities are at higher risk of developing severe and/or fatal illnesses. METHOD AND RESULT: We report the first case of a 60-year-old man with a 27-year history of type 1 diabetes mellitus, infected by SARS-CoV-2 presenting with an euglycaemic ketoacidosis and an acute respiratory distress syndrome. CONCLUSION: This case report reminds us of the importance of adjusting more recent glucose-lowering drugs, including sodium-glucose cotransporter 2 inhibitors, in the overall management of type 1 diabetic individuals during the ongoing COVID-19 outbreak.

Published
2022

33. Non-invasive screening, staging and management of metabolic dysfunction-associated fatty liver disease (MAFLD) in type 2 diabetes mellitus patients: what do we know so far ?

Author

UCL - (SLuc) Service de gastro-entérologie, UCL - (SLuc) Service d'endocrinologie et de nutrition, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, Binet, Quentin, Loumaye, Audrey, Preumont, Vanessa, Thissen, Jean-Paul, Hermans, Michel, Lanthier, Nicolas, UCL - (SLuc) Service de gastro-entérologie, UCL - (SLuc) Service d'endocrinologie et de nutrition, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, Binet, Quentin, Loumaye, Audrey, Preumont, Vanessa, Thissen, Jean-Paul, Hermans, Michel, and Lanthier, Nicolas

Abstract

Metabolic dysfunction-associated fatty liver disease (MAFLD) is the evidence of steatosis in the setting of a metabolic risk condition such as type 2 diabetes mellitus (T2DM). Indeed, T2DM and liver steatosis share common pathophysiological mechanisms, and one can lead to the other. MAFLD can progress from simple steatosis to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis as well as hepatocellular carcinoma (HCC). Because of the lack / disparity of guidelines for MAFLD screening, which is asymptomatic in its early stages, it is not rare that diabetic patients are belatedly diagnosed with NASH cirrhosis or HCC. We therefore recommend systematic non-invasive tests (NITs) that calculate an estimate of the risk based on readily available anthropometric and biological parameters. These include the fatty liver index (FLI) for steatosis detection and at least one of the following for fibrosis: non-alcoholic fatty liver disease fibrosis score (NFS), fibrosis-4 index (FIB-4) or Hepamet fibrosis score (HFS). Indeed, NFS and FIB-4 are the best predictors of liver-related events, while FIB-4 and HFS correlate with overall mortality. Systematic literature review found only few retrospective or cross-sectional studies using NITs for systematic steatosis and fibrosis screening in T2DM patients, with a crucial need for prospective studies. This screening strategy will allow targeted patients to be referred for further liver investigation (e.g. ultrasound, elastometry) and care. Current treatment modalities of MAFLD in T2DM patients range from lifestyle and dietary interventions to specific glucose-lowering drugs that recently showed some benefits regarding MAFLD, such as pioglitazone, glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors. Other treatments are currently under investigation.

Published
2022

34. Assessment of Clinical Outcomes Among Children and Adolescents Hospitalized With COVID-19 in 6 Sub-Saharan African Countries.

Author

UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Centre de pathologie sexuelle masculine, UCL - (SLuc) Service d'endocrinologie et de nutrition, Nachega, Jean B, Sam-Agudu, Nadia A, Machekano, Rhoderick N, Rabie, Helena, van der Zalm, Marieke M, Redfern, Andrew, Dramowski, Angela, O'Connell, Natasha, Pipo, Michel Tshiasuma, Tshilanda, Marc B, Byamungu, Liliane Nsuli, Masekela, Refiloe, Jeena, Prakash Mohan, Pillay, Ashendri, Gachuno, Onesmus W, Kinuthia, John, Ishoso, Daniel Katuashi, Amoako, Emmanuella, Agyare, Elizabeth, Agbeno, Evans K, Martyn-Dickens, Charles, Sylverken, Justice, Enimil, Anthony, Jibril, Aishatu Mohammed, Abdullahi, Asara M, Amadi, Oma, Umar, Umar Mohammed, Sigwadhi, Lovemore Nyasha, Hermans, Michel, Otokoye, John Otshudiema, Mbala-Kingebeni, Placide, Muyembe-Tamfum, Jean-Jacques, Zumla, Alimuddin, Sewankambo, Nelson K, Aanyu, Hellen Tukamuhebwa, Musoke, Philippa, Suleman, Fatima, Adejumo, Prisca, Noormahomed, Emilia V, Deckelbaum, Richard J, Fowler, Mary Glenn, Tshilolo, Léon, Smith, Gerald, Mills, Edward J, Umar, Lawal W, Siedner, Mark J, Kruger, Mariana, Rosenthal, Philip J, Mellors, John W, Mofenson, Lynne M, African Forum for Research and Education in Health (AFREhealth) COVID-19 Research Collaboration on Children and Adolescents, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Centre de pathologie sexuelle masculine, UCL - (SLuc) Service d'endocrinologie et de nutrition, Nachega, Jean B, Sam-Agudu, Nadia A, Machekano, Rhoderick N, Rabie, Helena, van der Zalm, Marieke M, Redfern, Andrew, Dramowski, Angela, O'Connell, Natasha, Pipo, Michel Tshiasuma, Tshilanda, Marc B, Byamungu, Liliane Nsuli, Masekela, Refiloe, Jeena, Prakash Mohan, Pillay, Ashendri, Gachuno, Onesmus W, Kinuthia, John, Ishoso, Daniel Katuashi, Amoako, Emmanuella, Agyare, Elizabeth, Agbeno, Evans K, Martyn-Dickens, Charles, Sylverken, Justice, Enimil, Anthony, Jibril, Aishatu Mohammed, Abdullahi, Asara M, Amadi, Oma, Umar, Umar Mohammed, Sigwadhi, Lovemore Nyasha, Hermans, Michel, Otokoye, John Otshudiema, Mbala-Kingebeni, Placide, Muyembe-Tamfum, Jean-Jacques, Zumla, Alimuddin, Sewankambo, Nelson K, Aanyu, Hellen Tukamuhebwa, Musoke, Philippa, Suleman, Fatima, Adejumo, Prisca, Noormahomed, Emilia V, Deckelbaum, Richard J, Fowler, Mary Glenn, Tshilolo, Léon, Smith, Gerald, Mills, Edward J, Umar, Lawal W, Siedner, Mark J, Kruger, Mariana, Rosenthal, Philip J, Mellors, John W, Mofenson, Lynne M, and African Forum for Research and Education in Health (AFREhealth) COVID-19 Research Collaboration on Children and Adolescents

Abstract

IMPORTANCE: Little is known about COVID-19 outcomes among children and adolescents in sub-Saharan Africa, where preexisting comorbidities are prevalent. OBJECTIVE: To assess the clinical outcomes and factors associated with outcomes among children and adolescents hospitalized with COVID-19 in 6 countries in sub-Saharan Africa. DESIGN, SETTING, AND PARTICIPANTS: This cohort study was a retrospective record review of data from 25 hospitals in the Democratic Republic of the Congo, Ghana, Kenya, Nigeria, South Africa, and Uganda from March 1 to December 31, 2020, and included 469 hospitalized patients aged 0 to 19 years with SARS-CoV-2 infection. EXPOSURES: Age, sex, preexisting comorbidities, and region of residence. MAIN OUTCOMES AND MEASURES: An ordinal primary outcome scale was used comprising 5 categories: (1) hospitalization without oxygen supplementation, (2) hospitalization with oxygen supplementation, (3) ICU admission, (4) invasive mechanical ventilation, and (5) death. The secondary outcome was length of hospital stay. RESULTS: Among 469 hospitalized children and adolescents, the median age was 5.9 years (IQR, 1.6-11.1 years); 245 patients (52.4%) were male, and 115 (24.5%) had comorbidities. A total of 39 patients (8.3%) were from central Africa, 172 (36.7%) from eastern Africa, 208 (44.3%) from southern Africa, and 50 (10.7%) from western Africa. Eighteen patients had suspected (n = 6) or confirmed (n = 12) multisystem inflammatory syndrome in children. Thirty-nine patients (8.3%) died, including 22 of 69 patients (31.9%) who required intensive care unit admission and 4 of 18 patients (22.2%) with suspected or confirmed multisystem inflammatory syndrome in children. Among 468 patients, 418 (89.3%) were discharged, and 16 (3.4%) remained hospitalized. The likelihood of outcomes with higher vs lower severity among children younger than 1 year expressed as adjusted odds ratio (aOR) was 4.89 (95% CI, 1.44-16.61) times higher than that of adolescents aged 15 to

Published
2022

35. Hormones and fertility.

Author

UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Centre de pathologie sexuelle masculine, UCL - (SLuc) Service d'endocrinologie et de nutrition, Linglart, Agnès, Christin-Maitre, Sophie, Maiter, Dominique, Touraine, Philippe, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Centre de pathologie sexuelle masculine, UCL - (SLuc) Service d'endocrinologie et de nutrition, Linglart, Agnès, Christin-Maitre, Sophie, Maiter, Dominique, and Touraine, Philippe

Abstract

No abstract available

Published
2022

36. Mild hyperprolactinemia in a couple: What impact on fertility?

Author

UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Centre de pathologie sexuelle masculine, UCL - (SLuc) Service d'endocrinologie et de nutrition, Maiter, Dominique, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Centre de pathologie sexuelle masculine, UCL - (SLuc) Service d'endocrinologie et de nutrition, and Maiter, Dominique

Abstract

Mild-to-moderate hyperprolactinemia is a frequent finding in young women presenting with infertility. Prolactin (PRL) concentration should be determined accurately, whether or not the patient has other symptoms suggestive of excess PRL such as galactorrhea or menstrual cycle disorder. After confirmation of persistent hyperprolactinemia on a second blood sample (avoiding conditions known to raise prolactin) and exclusion of macroprolactinemia, prolactinoma and other identifiable non-tumoral causes of hyperprolactinemia must be ruled out. Mildly elevated PRL levels may cause luteal insufficiency in cycling women and are associated with recurrent miscarriage. Any confirmed hyperprolactinemia should be treated in a woman who wishes or fails to become pregnant. Preference is given to cabergoline at the lowest possible dose that normalizes PRL, restoring fertility in the vast majority of cases. Evidence is much less robust in men, in whom PRL concentrations are less prone to increase and the reproductive system is less sensitive to the negative effects of hyperprolactinemia. Nevertheless, chronic and significant hyperprolactinemia in men may impair fertility or cause infertility (with or without hypogonadism) and must be treated, as in women. However, more clinical studies are clearly needed concerning male reproductive function. The significance of mild but persistent hyperprolactinemia in either member of a couple incidentally discovered during assisted reproductive technology (ART) procedures is unclear, and future evidence-based studies are needed to determine whether normalizing prolactin can improve ART outcome.

Published
2022

37. Treatment with sodium-glucose cotransporter-2 inhibitors in heart failure patients: The potential benefits of monitoring FGF-23 levels?

Author

UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service de biochimie médicale, UCL - (SLuc) Centre de pathologie sexuelle masculine, UCL - (SLuc) Service d'endocrinologie et de nutrition, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de cardiologie, Gruson, Damien, Pouleur, Anne-Catherine, Hermans, Michel, Ahn, Sylvie, Rousseau, Michel, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service de biochimie médicale, UCL - (SLuc) Centre de pathologie sexuelle masculine, UCL - (SLuc) Service d'endocrinologie et de nutrition, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de cardiologie, Gruson, Damien, Pouleur, Anne-Catherine, Hermans, Michel, Ahn, Sylvie, and Rousseau, Michel

Abstract

Inhibitors of sodium-glucose cotransporter 2 (SGLT2) inhibitors have shown effective glucose-lowering effects associated with improved clinical outcomes in diabetic patients and heart failure patients. As SGLT2 inhibitors can increase phosphate levels, they can also modulate FGF-23 production, a hormone directly involved in regulation of bone and mineral metabolism, but also a strong predictor of adverse cardiovascular events. We therefore discuss the relevance of FGF-23 as a companion testing of SGLT2 treatment, in addition to standard clinical biology tests.

Published
2022

38. Fetuin-A in Activated Liver Macrophages Is a Key Feature of Non-Alcoholic Steatohepatitis.

Author

UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Service d'endocrinologie et de nutrition, UCL - (SLuc) Service de gastro-entérologie, Etienne, Quentin, Lebrun, Valérie, Komuta, Mina, Navez, Benoît, Thissen, Jean-Paul, Leclercq, Isabelle, Lanthier, Nicolas, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Service d'endocrinologie et de nutrition, UCL - (SLuc) Service de gastro-entérologie, Etienne, Quentin, Lebrun, Valérie, Komuta, Mina, Navez, Benoît, Thissen, Jean-Paul, Leclercq, Isabelle, and Lanthier, Nicolas

Abstract

Fetuin-A, a plasma multifunctional protein known to play a role in insulin resistance, is usually presented as a liver secreted protein. However, fetuin-A adipose tissue production has been also described. Here, we evaluated fetuin-A production by the liver and the adipose tissue during metabolic dysfunction-associated fatty liver disease (MAFLD)-non-alcoholic steatohepatitis (NASH) development. Fetuin-A was evaluated by enzyme-linked immunosorbent assay (ELISA), polymerase chain reaction (PCR), Western blot, and immunofluorescence in male foz mice fed a normal diet (ND) or a high fat diet (HFD) at various timepoints and in MAFLD-NASH patients. Foz mice fed a short-term HFD developed liver steatosis, insulin resistance, and increased circulating levels of fetuin-A compared to ND-fed mice. In mice and patients with NASH, fetuin-A was located not only in healthy or steatotic hepatocytes but also in some macrophages forming lipogranulomas. In both mice and humans, a significant amount of fetuin-A was present in the adipose tissue compared to the liver. However, messenger ribonucleic acid levels and cell culture experiments indicate that fetuin-A is produced by the liver but not by the adipose tissue. In conclusion, fetuin-A is produced by steatotic hepatocytes at early timepoints in MAFLD and correlates with insulin resistance both in mice and humans. In NASH, fetuin-A also co-localizes with activated liver macrophages and could be interpreted as a signal released by damaged hepatocytes.

Published
2022

39. Evaluation of continuous glucose monitoring-derived person-specific HbA1c in the presence and absence of complications in type 1 diabetes.

Author

UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Xu, Yongjin, Oriot, Philippe, Dunn, Timothy C, Hermans, Michel, Ram, Yashesvini, Cheng, Alan, Ajjan, Ramzi A, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Xu, Yongjin, Oriot, Philippe, Dunn, Timothy C, Hermans, Michel, Ram, Yashesvini, Cheng, Alan, and Ajjan, Ramzi A

Abstract

AIM: To evaluate the accuracy of a novel kinetic model at predicting HbA1c in a real-world setting and to understand and explore the role of diabetes complications in altering the glucose-HbA1c relationship and the mechanisms involved. MATERIALS AND METHODS: Deidentified HbA1c and continuous glucose monitoring values were collected from 93 individuals with type 1 diabetes. Person-specific kinetic variables were used, including red blood cell (RBC) glucose uptake and lifespan, to characterize the relationship between glucose levels and HbA1c. The resulting calculated HbA1c (cHbA1c) was compared with glucose management indicator (GMI) for prospective agreement with laboratory HbA1c. RESULTS: The cohort (42 men and 51 women) had a median age (IQR) of 61 (43, 72) years and a diabetes duration of 21 (10, 33) years. A total of 24 459 days of continuous glucose monitoring (CGM) data were available and 357 laboratory HbA1c were used to assess the average glucose-HbA1c relationship. cHbA1c had a superior correlation with laboratory HbA1c compared with GMI with a mean absolute deviation of 1.7 and 6.7 mmol/mol, r2 = 0.85 and 0.44, respectively. The fraction within 10% of absolute relative deviation from laboratory HbA1c was 93% for cHbA1c and 63% for GMI. Macrovascular disease had no effect on the model's accuracy, whereas microvascular complications resulted in a trend towards higher HbA1c, secondary to increased RBC glucose uptake. CONCLUSIONS: cHbA1c, which takes into account RBC glucose uptake and lifespan, accurately reflects laboratory HbA1c in a real-world setting and can aid in the management of individuals with diabetes.

Published
2022

40. Innovations 2021 en endocrino-diabétologie

Author

UCL - (SLuc) Service d'endocrinologie et de nutrition, UCL - (SLuc) Service de médecine interne générale, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Centre du cancer, Burlacu, Maria Cristina, Furnica, Raluca-Maria, Constantinescu, Stefan, Alexopoulou, Orsalia, Maiter, Dominique, Hermans, Michel, Thissen, Jean-Paul, UCL - (SLuc) Service d'endocrinologie et de nutrition, UCL - (SLuc) Service de médecine interne générale, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Centre du cancer, Burlacu, Maria Cristina, Furnica, Raluca-Maria, Constantinescu, Stefan, Alexopoulou, Orsalia, Maiter, Dominique, Hermans, Michel, and Thissen, Jean-Paul

Published
2022

41. La chirurgie bariatrique : la guérison du diabète sucré de type 2 ?

Author

UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Thissen, Jean-Paul, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, and Thissen, Jean-Paul

Published
2022

42. F. Banting et Ch. Best sont-ils vraiment les 'découvreurs' de l'insuline il y a 100 ans ? Synthèse d'une relecture de l'histoire

Author

UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Buysschaert, Martin, de Leiva-Hidalgo, Alberto, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Buysschaert, Martin, and de Leiva-Hidalgo, Alberto

Published
2022

43. Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Pregnancy in Sub-Saharan Africa: A 6-Country Retrospective Cohort Analysis.

Author

UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Nachega, Jean B, Sam-Agudu, Nadia A, Machekano, Rhoderick N, Rosenthal, Philip J, Schell, Sonja, de Waard, Liesl, Bekker, Adrie, Gachuno, Onesmus W, Kinuthia, John, Mwongeli, Nancy, Budhram, Samantha, Vannevel, Valerie, Somapillay, Priya, Prozesky, Hans W, Taljaard, Jantjie, Parker, Arifa, Agyare, Elizabeth, Opoku, Akwasi Baafuor, Makarfi, Aminatu Umar, Abdullahi, Asara M, Adirieje, Chibueze, Ishoso, Daniel Katuashi, Pipo, Michel Tshiasuma, Tshilanda, Marc B, Bongo-Pasi Nswe, Christian, Ditekemena, John, Sigwadhi, Lovemore Nyasha, Nyasulu, Peter S, Hermans, Michel, Sekikubo, Musa, Musoke, Philippa, Nsereko, Christopher, Agbeno, Evans K, Yeboah, Michael Yaw, Umar, Lawal W, Ntakwinja, Mukanire, Mukwege, Denis M, Birindwa, Etienne Kajibwami, Mushamuka, Serge Zigabe, Smith, Emily R, Mills, Edward J, Otshudiema, John Otokoye, Mbala-Kingebeni, Placide, Tamfum, Jean-Jacques Muyembe, Zumla, Alimuddin, Tsegaye, Aster, Mteta, Alfred, Sewankambo, Nelson K, Suleman, Fatima, Adejumo, Prisca, Anderson, Jean R, Noormahomed, Emilia V, Deckelbaum, Richard J, Stringer, Jeffrey S A, Mukalay, Abdon, Taha, Taha E, Fowler, Mary Glenn, Wasserheit, Judith N, Masekela, Refiloe, Mellors, John W, Siedner, Mark J, Myer, Landon, Kengne, Andre-Pascal, Yotebieng, Marcel, Mofenson, Lynne M, Langenegger, Eduard, AFREhealth Research Collaboration on COVID-19 and Pregnancy, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Nachega, Jean B, Sam-Agudu, Nadia A, Machekano, Rhoderick N, Rosenthal, Philip J, Schell, Sonja, de Waard, Liesl, Bekker, Adrie, Gachuno, Onesmus W, Kinuthia, John, Mwongeli, Nancy, Budhram, Samantha, Vannevel, Valerie, Somapillay, Priya, Prozesky, Hans W, Taljaard, Jantjie, Parker, Arifa, Agyare, Elizabeth, Opoku, Akwasi Baafuor, Makarfi, Aminatu Umar, Abdullahi, Asara M, Adirieje, Chibueze, Ishoso, Daniel Katuashi, Pipo, Michel Tshiasuma, Tshilanda, Marc B, Bongo-Pasi Nswe, Christian, Ditekemena, John, Sigwadhi, Lovemore Nyasha, Nyasulu, Peter S, Hermans, Michel, Sekikubo, Musa, Musoke, Philippa, Nsereko, Christopher, Agbeno, Evans K, Yeboah, Michael Yaw, Umar, Lawal W, Ntakwinja, Mukanire, Mukwege, Denis M, Birindwa, Etienne Kajibwami, Mushamuka, Serge Zigabe, Smith, Emily R, Mills, Edward J, Otshudiema, John Otokoye, Mbala-Kingebeni, Placide, Tamfum, Jean-Jacques Muyembe, Zumla, Alimuddin, Tsegaye, Aster, Mteta, Alfred, Sewankambo, Nelson K, Suleman, Fatima, Adejumo, Prisca, Anderson, Jean R, Noormahomed, Emilia V, Deckelbaum, Richard J, Stringer, Jeffrey S A, Mukalay, Abdon, Taha, Taha E, Fowler, Mary Glenn, Wasserheit, Judith N, Masekela, Refiloe, Mellors, John W, Siedner, Mark J, Myer, Landon, Kengne, Andre-Pascal, Yotebieng, Marcel, Mofenson, Lynne M, Langenegger, Eduard, and AFREhealth Research Collaboration on COVID-19 and Pregnancy

Abstract

BACKGROUND: Few data are available on COVID-19 outcomes among pregnant women in sub-Saharan Africa (SSA), where high-risk comorbidities are prevalent. We investigated the impact of pregnancy on SARS-CoV-2 infection and of SARS-CoV-2 infection on pregnancy to generate evidence for health policy and clinical practice. METHODS: We conducted a 6-country retrospective cohort study among hospitalized women of childbearing age between 1 March 2020 and 31 March 2021. Exposures were (1) pregnancy and (2) a positive SARS-CoV-2 RT-PCR test. The primary outcome for both analyses was intensive care unit (ICU) admission. Secondary outcomes included supplemental oxygen requirement, mechanical ventilation, adverse birth outcomes, and in-hospital mortality. We used log-binomial regression to estimate the effect between pregnancy and SARS-CoV-2 infection. Factors associated with mortality were evaluated using competing-risk proportional subdistribution hazards models. RESULTS: Our analyses included 1315 hospitalized women: 510 pregnant women with SARS-CoV-2, 403 nonpregnant women with SARS-CoV-2, and 402 pregnant women without SARS-CoV-2 infection. Among women with SARS-CoV-2 infection, pregnancy was associated with increased risk for ICU admission (adjusted risk ratio [aRR]: 2.38; 95% CI: 1.42-4.01), oxygen supplementation (aRR: 1.86; 95% CI: 1.44-2.42), and hazard of in-hospital death (adjusted sub-hazard ratio [aSHR]: 2.00; 95% CI: 1.08-3.70). Among pregnant women, SARS-CoV-2 infection increased the risk of ICU admission (aRR: 2.0; 95% CI: 1.20-3.35), oxygen supplementation (aRR: 1.57; 95% CI: 1.17-2.11), and hazard of in-hospital death (aSHR: 5.03; 95% CI: 1.79-14.13). CONCLUSIONS: Among hospitalized women in SSA, both SARS-CoV-2 infection and pregnancy independently increased risks of ICU admission, oxygen supplementation, and death. These data support international recommendations to prioritize COVID-19 vaccination among pregnant women.

Published
2022

44. Identification of myokines potentially involved in the improvement of glucose homeostasis after bariatric surgery

Author

UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Orioli, Laura, Canouil, Mickaël, Sawadogo, Kiswendsida Clovis, Ning, Lijiao, Deldicque, Louise, Lause, Pascale, de Barsy, Marie, Froguel, Philippe, Loumaye, Audrey, Deswysen, Yannick, Navez, Benoît, Bonnefond, Amelie, Thissen, Jean-Paul, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Orioli, Laura, Canouil, Mickaël, Sawadogo, Kiswendsida Clovis, Ning, Lijiao, Deldicque, Louise, Lause, Pascale, de Barsy, Marie, Froguel, Philippe, Loumaye, Audrey, Deswysen, Yannick, Navez, Benoît, Bonnefond, Amelie, and Thissen, Jean-Paul

Published
2022

45. Predictive factors for weight loss and weight regain after bariatric surgery

Author

UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Chirita, Nada, Thissen, Jean-Paul, Loumaye, Audrey, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Chirita, Nada, Thissen, Jean-Paul, and Loumaye, Audrey

Published
2022

46. Apport de l’imagerie dans la cachexie cancéreuse.

Author

UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Loumaye, Audrey, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, and Loumaye, Audrey

Published
2022

47. Les incrétines chez le patient obèse non diabétique

Author

UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Loumaye, Audrey, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, and Loumaye, Audrey

Published
2022

48. Effects of Hormones on Breast Development and Breast Cancer Risk in Transgender Women.

Author

UCL - SSS/DDUV/GEHU - Génétique, UCL - SSS/IREC/GYNE - Pôle de Gynécologie, UCL - SSS/IREC/MORF - Pôle de Morphologie, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service de radiologie, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Service de chirurgie plastique, UCL - (SLuc) Service de gynécologie et d'andrologie, UCL - (SLuc) Service d'endocrinologie et de nutrition, UCL - (SLuc) Unité d'oncologie médicale, Berlière, Martine, Coche, Maximilienne, Lacroix, Camille, Riggi, Julia, Coyette, Maude, Coulie, Julien, Galant, Christine, Fellah, Latifa, Leconte, Isabelle, Maiter, Dominique, Duhoux, François, Francois, Aline, UCL - SSS/DDUV/GEHU - Génétique, UCL - SSS/IREC/GYNE - Pôle de Gynécologie, UCL - SSS/IREC/MORF - Pôle de Morphologie, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service de radiologie, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Service de chirurgie plastique, UCL - (SLuc) Service de gynécologie et d'andrologie, UCL - (SLuc) Service d'endocrinologie et de nutrition, UCL - (SLuc) Unité d'oncologie médicale, Berlière, Martine, Coche, Maximilienne, Lacroix, Camille, Riggi, Julia, Coyette, Maude, Coulie, Julien, Galant, Christine, Fellah, Latifa, Leconte, Isabelle, Maiter, Dominique, Duhoux, François, and Francois, Aline

Abstract

Transgender women experience gender dysphoria due to a gender assignment at birth that is incongruent with their gender identity. Transgender people undergo different surgical procedures and receive sex steroids hormones to reduce psychological distress and to induce and maintain desired physical changes. These persons on feminizing hormones represent a unique population to study the hormonal effects on breast development, to evaluate the risk of breast cancer and perhaps to better understand the precise role played by different hormonal components. In MTF (male to female) patients, hormonal treatment usually consists of antiandrogens and estrogens. Exogenous hormones induce breast development with the formation of ducts and lobules and an increase in the deposition of fat. A search of the existing literature dedicated to hormone regimens for MTF patients, their impact on breast tissue (incidence and type of breast lesions) and breast cancer risk provided the available information for this review. The evaluation of breast cancer risk is currently complicated by the heterogeneity of administered treatments and a lack of long-term follow-up in the great majority of studies. Large studies with longer follow-up are required to better evaluate the breast cancer risk and to understand the precise mechanisms on breast development of each exogenous hormone.

Published
2022

49. Prioritizing Pregnant Women for Coronavirus Disease 2019 Vaccination in African Countries.

Author

UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Nachega, Jean B, Sam-Agudu, Nadia A, Siedner, Mark J, Rosenthal, Philip J, Mellors, John W, Zumla, Alimuddin, Hermans, Michel, Ntakwinja, Mukanire B, Mukwege, Denis M, Langenegger, Eduard, Mofenson, Lynne M, African Forum for Research and Education in Health (AFREhealth) Research Collaboration on COVID-19 and Pregnancy, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition, Nachega, Jean B, Sam-Agudu, Nadia A, Siedner, Mark J, Rosenthal, Philip J, Mellors, John W, Zumla, Alimuddin, Hermans, Michel, Ntakwinja, Mukanire B, Mukwege, Denis M, Langenegger, Eduard, Mofenson, Lynne M, and African Forum for Research and Education in Health (AFREhealth) Research Collaboration on COVID-19 and Pregnancy

Abstract

Coronavirus disease 2019 (COVID-19) in pregnancy is associated with excess maternal and infant morbidity and mortality in both African and higher-resource settings. Furthermore, mounting evidence demonstrates the safety and efficacy of COVID-19 vaccination for pregnant women and infants. However, national guidelines in many African countries are equivocal or lack recommendations on COVID-19 vaccine in pregnancy. We summarize key data on COVID-19 epidemiology and vaccination among pregnant African women to highlight major barriers to vaccination and recommend 4 interventions. First, policymakers should prioritize pregnant women for COVID-19 vaccination, with a target of 100% coverage. Second, empirically supported public health campaigns should be sustainably implemented to inform and support pregnant women and their healthcare providers in overcoming vaccine hesitancy. Third, COVID-19 vaccination for pregnant women should be expanded to include antenatal care, obstetrics/gynecology, and targeted mass vaccination campaigns. Fourth, national monitoring and evaluation of COVID-19 vaccine uptake, safety, surveillance, and prospective outcomes assessment should be conducted.

Published
2022

50. Screening for NAFLD and its severity in type 2 diabetic patients: value of magnetic resonance imaging and outstanding issues.

Author

UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Service d'endocrinologie et de nutrition, UCL - (SLuc) Service d'hépato-gastro-entérologie, Binet, Quentin, Hermans, Michel, Lanthier, Nicolas, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Service d'endocrinologie et de nutrition, UCL - (SLuc) Service d'hépato-gastro-entérologie, Binet, Quentin, Hermans, Michel, and Lanthier, Nicolas

Abstract

To the Editor: Weread Ajmera et al.’s original manuscript with great interest. Screening for non-alcoholic fatty liver disease (NAFLD) is indeed crucial in the type 2 diabetes population because of the intricate links between insulin resistance and hepatic steatosis. [...]

Published
2022

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