Search

Your search keyword '"Endo, Shuichiro"' showing total 47 results
Start Over Author "Endo, Shuichiro"
47 results on '"Endo, Shuichiro"'

4. Nation-wide cohort study of remission induction therapy using rituximab in Japanese patients with antineutrophil cytoplasmic antibody–associated vasculitis: Effectiveness and safety in the first 6 months

Author

Nagasaka, Kenji, primary, Amano, Koichi, additional, Dobashi, Hiroaki, additional, Nagafuchi, Hiroko, additional, Sada, Ken-Ei, additional, Komagata, Yoshinori, additional, Yamamura, Masahiro, additional, Kato, Masaru, additional, Endo, Tomomi, additional, Nakaya, Izaya, additional, Takeuchi, Tsutomu, additional, Murakawa, Yohko, additional, Sugihara, Takahiko, additional, Saito, Masaya, additional, Hayashi, Taichi, additional, Furuta, Shunsuke, additional, Tamura, Naoto, additional, Karasawa, Kazunori, additional, Banno, Shogo, additional, Endo, Shuichiro, additional, Majima, Masako, additional, Kaname, Shinya, additional, Arimura, Yoshiriro, additional, and Harigai, Masayoshi, additional

Published
2022
Full Text
View/download PDF

6. Lineage tracing analysis defines erythropoietin-producing cells as a distinct subpopulation of resident fibroblasts with unique behaviors

Author

60706703, 70378769, Kaneko, Keiichi, Sato, Yuki, Uchino, Eiichiro, Toriu, Naoya, Shigeta, Mayo, Kiyonari, Hiroshi, Endo, Shuichiro, Fukuma, Shingo, Yanagita, Motoko, 60706703, 70378769, Kaneko, Keiichi, Sato, Yuki, Uchino, Eiichiro, Toriu, Naoya, Shigeta, Mayo, Kiyonari, Hiroshi, Endo, Shuichiro, Fukuma, Shingo, and Yanagita, Motoko

Abstract

Erythropoietin (Epo) is produced by a subpopulation of resident fibroblasts in the healthy kidney. We have previously demonstrated that, during kidney fibrosis, kidney fibroblasts including Epo-producing cells transdifferentiate into myofibroblasts and lose their Epo-producing ability. However, it remains unclear whether Epo-producing cells survive and transform into myofibroblasts during fibrosis because previous studies did not specifically label Epo-producing cells in pathophysiological conditions. Here, we generated Epo[CreERT2/+] mice, a novel mouse strain that enables labeling of Epo-producing cells at desired time points and examined the behaviors of Epo-producing cells under pathophysiological conditions. Lineage -labeled cells that were producing Epo when labeled were found to be a small subpopulation of fibroblasts located in the interstitium of the kidney, and their number increased during phlebotomy-induced anemia. Around half of lineage-labeled cells expressed Epo mRNA, and this percentage was maintained even 16 weeks after recombination, supporting the idea that a distinct subpopulation of cells with Epo-producing ability makes Epo repeatedly. During fibrosis caused by ureteral obstruction, Epo[CreERT2/+] -labeled cells were found to transdifferentiate into myofibroblasts with concomitant loss of Epo-producing ability, and their numbers and the proportion among resident fibroblasts increased during fibrosis, indicating their high proliferative capacity. Finally, we confirmed that EpoCreERT2/+-labeled cells that lost their Epo-producing ability during fibrosis regained their ability after kidney repair due to relief of the ureteral obstruction. Thus, our analyses have revealed previously unappreciated characteristic behaviors of Epo-producing cells, which had not been clearly distinguished from those of resident fibroblasts.

Published
2022

7. A Study on Surgical Outcomes of Pars Flaccida Cholesteatoma

Author

Hayashi, Akira, primary, Tanaka, Shota, additional, Endo, Shuichiro, additional, Takahashi, Mari, additional, Horiuchi, Kiwako, additional, Shimamura, Ayumi, additional, Ishii, Hiroki, additional, Matsuoka, Tomokazu, additional, Sakurai, Daiju, additional, and Masuyama, Keisuke, additional

Published
2022
Full Text
View/download PDF

11. Monoclonal gammopathy of renal significance (MGRS)-related AL amyloidosis complicated by amyloid myopathy: a case report

Author

40760153, 60749555, 90378779, 00335283, 90216771, 70378769, Ono, Erina, Ishii, Akira, Higashi, Yoshiaki, Koita, Natsuko, Ayaki, Takashi, Tanigaki, Katsuya, Takayanagi, Shunsuke, Kondo, Naoya, Sakai, Kaoru, Endo, Shuichiro, Yokoi, Hideki, Matsubara, Takeshi, Minamiguchi, Sachiko, Nishino, Ichizo, Takahashi, Ryosuke, Yanagita, Motoko, 40760153, 60749555, 90378779, 00335283, 90216771, 70378769, Ono, Erina, Ishii, Akira, Higashi, Yoshiaki, Koita, Natsuko, Ayaki, Takashi, Tanigaki, Katsuya, Takayanagi, Shunsuke, Kondo, Naoya, Sakai, Kaoru, Endo, Shuichiro, Yokoi, Hideki, Matsubara, Takeshi, Minamiguchi, Sachiko, Nishino, Ichizo, Takahashi, Ryosuke, and Yanagita, Motoko

Published
2021

12. A Study on Tympanoplasty in Chronic Otitis Media

Author

Tanaka, Shota, primary, Hayashi, Akira, additional, Endo, Shuichiro, additional, Takahashi, Mari, additional, Horiuchi, Kiwako, additional, Shimamura, Ayumi, additional, Matsuoka, Tomokazu, additional, Ishii, Hiroki, additional, and Sakurai, Daiju, additional

Published
2021
Full Text
View/download PDF

15. A digest of the evidence-based Clinical Practice Guideline for Rapidly Progressive Glomerulonephritis 2020.

Author

Usui, Joichi, Kawashima, Soko, Sada, Ken-Ei, Miyawaki, Yoshia, Nakazawa, Daigo, Itabashi, Mitsuyo, Endo, Shuichiro, Endo, Tomomi, Oda, Takashi, Ohya, Masaki, Kitagawa, Kiyoki, Nagasawa, Tasuku, Hirahashi, Junichi, Hiromura, Keiju, Kawaguchi, Takahisa, Takayasu, Mamiko, Tsuboi, Naotake, Hirayama, Kouichi, Muso, Eri, and Yumura, Wako

Subjects
IGA glomerulonephritis, HEMATURIA, GLOMERULONEPHRITIS, HEPATITIS B
Abstract

Maintenance therapy (remission maintenance therapy for treating vasculitis): approximately 3-6 months after treatment initiation and after confirming that the symptoms of vasculitis, such as progression of renal failure, have disappeared. Treatment of anti-GBM antibody nephritis Patients with anti-GBM antibody nephritis have the worst renal prognosis among patients with RPGN; survival rate is very poor in the presence of pulmonary hemorrhage. Grades of recommendations: "We recommend" "We suggest" None Definition of disease Rapidly progressive glomerulonephritis (RPGN) is defined in Japan as "a syndrome that rapidly progresses to renal failure within a few weeks or months and is accompanied by urinary findings of nephritis." Diagnosis Differential diagnosis RPGN is a clinical syndrome that is classified based on its manifestations: primary RPGN, which only damages the kidneys, or secondary RPGN, which occurs in association with other systemic disorders and infections. [Extracted from the article]

Published
2021
Full Text
View/download PDF

21. P2_131 Two International Multiregional Investigator Initiated Clinical Trials on Vasculitis: Collaboration with EUVAS, VCRC and Nationwide Vasculitis Study Groups of Japan

Author

Ito-Ihara, Toshiko, primary, Furuta, Shunsuke, additional, Komagata, Yoshinori, additional, Muso, Eri, additional, Endo, Tomomi, additional, Uchida, Shunya, additional, Kono, Hajime, additional, Hamano, Yoshitomo, additional, Tsukamoto, Tatsuo, additional, Endo, Shuichiro, additional, Yamagata, Kunihiro, additional, Walsh, Michael, additional, Merkel, Peter, additional, Jayne, David, additional, Suzuki, Kazuo, additional, Arimura, Yoshihiro, additional, Makino, Hirofumi, additional, and Fujimoto, Shouichi, additional

Published
2017
Full Text
View/download PDF

23. A case of ileocecal obstruction caused by intestinal endometriosis treated by total laparoscopic surgery

Author

Tsuzuki, Yoko, primary, Aoki, Yoichi, additional, Kikuchi, Iwaho, additional, Nojima, Michio, additional, Tanaka, Saki, additional, Kasahara, Makiko, additional, Matsuzawa, Nana, additional, Aoi, Hiromi, additional, Nakao, Satoko, additional, Otsuka, Aya, additional, Kasahara, Hanako, additional, Koizumi, Akari, additional, Endo, Shuichiro, additional, Suzuki, Chikako, additional, Tajima, Atsushi, additional, and Yoshida, Koyo, additional

Published
2016
Full Text
View/download PDF

25. Identification and confirmation of carbohydrate structure recognized by an anti-sperm monoclonal antibody, Ts4, using lectin-binding and glycohydrolase-digestion assays

Author

Yoshitake, Hiroshi, primary, Hashii, Noritaka, additional, Kawasaki, Nana, additional, Oda, Risako, additional, Kawasaki, Yu, additional, Sakuraba, Mayumi, additional, Endo, Shuichiro, additional, Takamori, Kenji, additional, Hasegawa, Akiko, additional, Fujiwara, Hiroshi, additional, and Araki, Yoshihiko, additional

Published
2015
Full Text
View/download PDF

28. Bmp7 maintains undifferentiated kidney progenitor population and determines nephron numbers at birth.

Author

80533380, 80359786, 70378769, Tomita, Mayumi, Asada, Misako, Asada, Nariaki, Nakamura, Jin, Oguchi, Akiko, Higashi, Atsuko Y, Endo, Shuichiro, Robertson, Elizabeth, Kimura, Takeshi, Kita, Toru, Economides, Aris N, Kreidberg, Jordan, Yanagita, Motoko, 80533380, 80359786, 70378769, Tomita, Mayumi, Asada, Misako, Asada, Nariaki, Nakamura, Jin, Oguchi, Akiko, Higashi, Atsuko Y, Endo, Shuichiro, Robertson, Elizabeth, Kimura, Takeshi, Kita, Toru, Economides, Aris N, Kreidberg, Jordan, and Yanagita, Motoko

Abstract

The number of nephrons, the functional units of the kidney, varies among individuals. A low nephron number at birth is associated with a risk of hypertension and the progression of renal insufficiency. The molecular mechanisms determining nephron number during embryogenesis have not yet been clarified. Germline knockout of bone morphogenetic protein 7 (Bmp7) results in massive apoptosis of the kidney progenitor cells and defects in early stages of nephrogenesis. This phenotype has precluded analysis of Bmp7 function in the later stage of nephrogenesis. In this study, utilization of conditional null allele of Bmp7 in combination with systemic inducible Cre deleter mice enabled us to analyze Bmp7 function at desired time points during kidney development, and to discover the novel function of Bmp7 to inhibit the precocious differentiation of the progenitor cells to nephron. Systemic knockout of Bmp7 in vivo after the initiation of kidney development results in the precocious differentiation of the kidney progenitor cells to nephron, in addition to the prominent apoptosis of progenitor cells. We also confirmed that in vitro knockout of Bmp7 in kidney explant culture results in the accelerated differentiation of progenitor population. Finally we utilized colony-forming assays and demonstrated that Bmp7 inhibits epithelialization and differentiation of the kidney progenitor cells. These results indicate that the function of Bmp7 to inhibit the precocious differentiation of the progenitor cells together with its anti-apoptotic effect on progenitor cells coordinately maintains renal progenitor pool in undifferentiated status, and determines the nephron number at birth.

Published
2013

29. Bmp7 Maintains Undifferentiated Kidney Progenitor Population and Determines Nephron Numbers at Birth

Author

Tomita, Mayumi, primary, Asada, Misako, additional, Asada, Nariaki, additional, Nakamura, Jin, additional, Oguchi, Akiko, additional, Higashi, Atsuko Y., additional, Endo, Shuichiro, additional, Robertson, Elizabeth, additional, Kimura, Takeshi, additional, Kita, Toru, additional, Economides, Aris N., additional, Kreidberg, Jordan, additional, and Yanagita, Motoko, additional

Published
2013
Full Text
View/download PDF

31. Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma

Author

Yoshitake, Hiroshi, primary, Yokoi, Hidenori, additional, Ishikawa, Hitoshi, additional, Maruyama, Mayuko, additional, Endo, Shuichiro, additional, Nojima, Michio, additional, Yoshida, Koyo, additional, Yoshikawa, Hiroshi, additional, Suzuki, Fujihiko, additional, Takamori, Kenji, additional, Fujiwara, Hiroshi, additional, and Araki, Yoshihiko, additional

Published
2013
Full Text
View/download PDF

45. Nation-wide cohort study of remission induction therapy using rituximab in Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis: Effectiveness and safety in the first 6 months.

Author

Nagasaka K, Amano K, Dobashi H, Nagafuchi H, Sada KE, Komagata Y, Yamamura M, Kato M, Endo T, Nakaya I, Takeuchi T, Murakawa Y, Sugihara T, Saito M, Hayashi T, Furuta S, Tamura N, Karasawa K, Banno S, Endo S, Majima M, Kaname S, Arimura Y, and Harigai M

Subjects
Humans, Rituximab adverse effects, Antibodies, Antineutrophil Cytoplasmic, Cohort Studies, East Asian People, Treatment Outcome, Remission Induction, Granulomatosis with Polyangiitis, Microscopic Polyangiitis, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Abstract

Objectives: The aim of this article is to evaluate the effectiveness and safety of rituximab (RTX) for microscopic polyangiitis and granulomatosis with polyangiitis in Japan., Methods: In this prospective observational study, all patients with microscopic polyangiitis and granulomatosis with polyangiitis administered RTX were enrolled at each institution. During the observation period of 2 years, data up to 6 months were analysed. Cox proportional hazards analysis was used to assess the factors associated with an outcome., Results: Of the 75 patients who received RTX for remission induction therapy, 53 achieved remission by the sixth month and 50 were in remission at the sixth month. During therapy, 38 serious adverse events were observed in 24 patients, 21 serious infections in 16 patients, and 9 patients died. No factors were associated with remission; however, there was a significant difference between patients with and without remission in serious adverse events (22.6% vs. 54.5%), serious infections (11.3% vs. 45.4%), and death (1.9% vs. 36.4%). The hazard ratio (95% confidence interval) for serious infection was 3.49 (1.29-9.74) for patients aged ≥ 75 years and 3.53 (1.31-9.53) for pulmonary complications. Four patients maintained remission for 6 months., Conclusions: The effectiveness and safety of RTX for microscopic polyangiitis and granulomatosis with polyangiitis for up to 6 months was demonstrated., (© Japan College of Rheumatology 2023. Published by Oxford University Press.)

Published
2023
Full Text
View/download PDF

46. Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma.

Author

Yoshitake H, Yokoi H, Ishikawa H, Maruyama M, Endo S, Nojima M, Yoshida K, Yoshikawa H, Suzuki F, Takamori K, Fujiwara H, and Araki Y

Subjects
Aged, Blotting, Western, Carcinoma, Squamous Cell pathology, Female, Head and Neck Neoplasms pathology, Humans, Immunohistochemistry, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Staging, Biomarkers, Tumor biosynthesis, Carcinoma, Squamous Cell metabolism, Head and Neck Neoplasms metabolism, Membrane Proteins biosynthesis
Abstract

TEX101, a member of the Ly-6/urokinase-type plasminogen activator receptor (LU)-family we previously identified, is a germ cell-marker glycoprotein. To date, it is reported that some members of the protein-family are overexpressed in a variety of cancer tissues. We previously reported Ly6k, a member of the LU-family, as an association molecule with TEX101 in murine male germ cells. LY6K (a human homologue of Ly6k) is overexpressed in head and neck squamous cell carcinomas (HNSCC). These facts led us to speculate that TEX101 may also exist in HNSCC, like LY6K. Using an anti-human TEX101 polyclonal antibody (pAb) established, we examined the expression of TEX101 protein in cancer tissues by immunohistochemical analysis. TEX101 was detected in the cancer cells of some tissue specimens from patients with HNSCC, whereas the normal squamous epithelium was immunonegative. The TEX101 protein was detected in cancer cells from 54 out of 64 (80.6%) patients with HNSCC. The rate of lymph nodes metastasis tends to be low in TEX101-positive patients, compared to patients with weakly positive and negative expression of TEX101. The present results imply that TEX101 is a novel cancer-related protein and may be useful as a marker for prognosis/diagnosis of HNSCC.

Published
2012
Full Text
View/download PDF

47. Cetirizine decreases interleukin-4, interleukin-5, and interferon-gamma gene expressions in nasal-associated lymphoid tissue of sensitized mice.

Author

Jin HR, Okamoto Y, Matsuzaki Z, Endo S, and Ito E

Subjects
Airway Resistance immunology, Analysis of Variance, Animals, Disease Models, Animal, Eosinophils drug effects, Gene Expression, Histamine metabolism, Interferon-gamma analysis, Interleukin-4 analysis, Interleukin-5 analysis, Lymphoid Tissue immunology, Male, Mice, Mice, Inbred C57BL, Nasal Mucosa cytology, Nasal Mucosa drug effects, Ovalbumin, Polymerase Chain Reaction, Probability, RNA, Messenger analysis, Reference Values, Cetirizine pharmacology, Interferon-gamma metabolism, Interleukin-4 metabolism, Interleukin-5 metabolism, Lymphoid Tissue drug effects, Nasal Mucosa immunology, Rhinitis immunology
Abstract

Although the action of cetirizine dihydrochloride (cetirizine), a potent histamine H1 receptor antagonist, has been well known, its effect on the cytokine profiles in the nasal immune inductive site has not been elucidated yet. We studied the effect of cetirizine on the cytokine profiles in the nasal-associated lymphoid tissue (NALT), which is a principal mucosal lymphoid tissue of the respiratory tract in rodents. Two different doses of cetirizine were given intraorally for 5 days before the nasal challenge of ovalbumin in sensitized mice. The sensitized group was given normal saline instead of cetirizine, and the nonsensitized group had no sensitization or medication. The cytokine gene expressions in the NALT taken from the mice were investigated with real-time quantitative reverse-transcription polymerase chain reaction. The effect of cetirizine on the allergic symptom score, histamine threshold, and the eosinophil count in the nasal septal mucosa were examined also. Compared with the normal mice, the sensitized mice showed significantly increased levels of interleukin (IL)-4 and IL-5 gene expression although the increase of interferon (INF)-gamma gene expression was not significant. In the cetirizine groups, the levels of expression of IL-4, IL-5, and INF-gamma in the NALT were significantly decreased compared with the sensitized group. The cetirizine groups also showed decreased allergic symptom score, histamine threshold, and eosinophil count in the nasal septal mucosa compared with the sensitized group. In conclusion, cetirizine reduced the levels of expression of IL-4, IL-5, and INF-gamma in the NALT of ovalbumin-sensitized mice. Cetirizine also reduced the acute allergic symptom, histamine sensitivity, and eosinophil count in the nasal septal mucosa.

Published
2002

Catalog

Books, media, physical & digital resources
See catalog results