65 results on '"Ender Hur"'
Search Results
2. A new technique for the detection of dry weight in hemodialysis patients: Estimated pulmonary capillary wedge pressure. A tissue Doppler imaging study
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Gürsel Yildiz, Ender Hur, Kemal Magden, Ferhan Candan, Mansur Kayatas, İbrahim Yildirim, and Mehmet Birhan Yilmaz
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Peso seco ,Presión capilar pulmonar estimada ,Doppler tisular ,Ecocardiografía ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Background and objective: Fluid overload is an important factor of morbidity and mortality in hemodialysis patients. Today correct determination of dry weight (DW) remains an important issue of hemodialysis practice. Within this context, it is subjected to new method searching. The objective of this study was to calculate estimated pulmonary capillary wedge pressure (ePCWP) with Tissue Doppler Imaging (TDI) in hemodialysis patients and to evaluate its correlation with the other volume markers and to evaluate whether it can be a new method for detection of DW. Materials and methods: Echocardiographic, hemodynamic, and biochemical volume markers of 41 hemodialysis patients were evaluated in the pre- and post-dialysis periods. Patients were divided into two groups based on ePCWP values (Group 1 ePCWP 20 mmHg). Results: In the pre-dialysis period; parameters related to volume load including ePCWP, systolic blood pressure, mean arterial pressure, pulse pressure, left atrial diameter, left atrial volume, E/é, ratio and E/Vp ratio were statistically significantly higher in Group2 compared to Group1. On the other hand, strong correlations were found between pre-dialysis ePCWP and systolic blood pressure, mean arterial pressure, pulse pressure, NT-ProBNP, left atrial diameter, E/é ratio and E/Vp ratio. Conclusions: Strong correlations found between ePCWP which was calculated with TDI and the other volume markers both in pre-dialysis and post-dialysis periods. These findings can provide a significant contribution to routine evaluating of DW in hemodialysis patients. From this aspect, the prediction of ePCWP with TDI can be a new practical and reproducible method for the determination of DW. Resumen: Antecedentes y objetivo: La hipervolemia es un factor importante de morbimortalidad en pacientes en hemodiálisis. Actualmente, la determinación correcta del peso seco (PS) sigue siendo un aspecto importante en la práctica de la hemodiálisis. Por este motivo se siguen buscando nuevos métodos. El objetivo de este estudio fue calcular la presión capilar pulmonar (PCPe) mediante ecografía Doppler tisular (EDT) en pacientes en hemodiálisis, con el fin de evaluar su correlación con los demás marcadores de volumen y valorar si podría ser un nuevo método para la determinación del PS. Materiales y métodos: Se evaluaron los marcadores de volumen ecocardiográficos, hemodinámicos y bioquímicos de 41 pacientes en hemodiálisis en los periodos previos y posteriores a la diálisis. Los pacientes se dividieron en 2 grupos en función de los valores de PCPe (PCPe del grupo 1 0 mmHg). Resultados: En el periodo previo a la diálisis, los parámetros relacionados con la carga de volumen, como la PCPe, la presión arterial sistólica, la presión arterial media, la presión diferencial, el diámetro auricular izquierdo, el volumen auricular izquierdo y los cocientes E/é y E/Vp fueron superiores de forma estadísticamente significativa en el grupo 2 en comparación con el grupo 1. Por otro lado, se observaron correlaciones importantes entre la PCPe previa a la diálisis y la presión arterial sistólica, la presión arterial media, la presión diferencial, el NT-proBNP, el diámetro auricular izquierdo y los cocientes E/é y E/Vp. Conclusiones: Se observaron correlaciones importantes entre la PCPe calculada mediante EDT y los demás marcadores de volumen, tanto en el periodo previo a la diálisis como en el posterior. Estos resultados pueden representar una contribución significativa a la evaluación ordinaria del PS en pacientes en hemodiálisis. Desde este punto de vista, la predicción de la PCPe mediante EDT puede ser un método práctico y reproducible para la determinación del PS.
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- 2022
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3. Determinants of mortality in a large group of hemodialysis patients hospitalized for COVID-19
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Kenan Turgutalp, Savas Ozturk, Mustafa Arici, Necmi Eren, Numan Gorgulu, Mahmut Islam, Sami Uzun, Tamer Sakaci, Zeki Aydin, Erkan Sengul, Bulent Demirelli, Yavuz Ayar, Mehmet Riza Altiparmak, Savas Sipahi, Ilay Berke Mentes, Tuba Elif Ozler, Ebru Gok Oguz, Bulent Huddam, Ender Hur, Rumeyza Kazancioglu, Ozkan Gungor, Bulent Tokgoz, Halil Zeki Tonbul, Alaattin Yildiz, Siren Sezer, Ali Riza Odabas, and Kenan Ates
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Hemodialysis ,COVID-19 ,Radiological manifestations ,Mortality ,Clinical findings ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background Maintenance hemodialysis (MHD) patients are at increased risk for coronavirus disease 2019 (COVID-19). The aim of this study was to describe clinical, laboratory, and radiologic characteristics and determinants of mortality in a large group of MHD patients hospitalized for COVID-19. Methods This multicenter, retrospective, observational study collected data from 47 nephrology clinics in Turkey. Baseline clinical, laboratory and radiological characteristics, and COVID-19 treatments during hospitalization, need for intensive care and mechanical ventilation were recorded. The main study outcome was in-hospital mortality and the determinants were analyzed by Cox regression survival analysis. Results Of 567 MHD patients, 93 (16.3%) patients died, 134 (23.6%) patients admitted to intensive care unit (ICU) and 91 of the ones in ICU (67.9%) needed mechanical ventilation. Patients who died were older (median age, 66 [57–74] vs. 63 [52–71] years, p = 0.019), had more congestive heart failure (34.9% versus 20.7%, p = 0.004) and chronic obstructive pulmonary disease (23.6% versus 12.7%, p = 0.008) compared to the discharged patients. Most patients (89.6%) had radiological manifestations compatible with COVID-19 pulmonary involvement. Median platelet (166 × 103 per mm3 versus 192 × 103 per mm3, p = 0.011) and lymphocyte (800 per mm3 versus 1000 per mm3, p
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- 2021
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4. Serum Sulphate Levels in Hemodialysis Patients
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Ibrahim Yildirim, Ender Hur, Kemal Magden, Sevil İlikhan, Hüseyin Engin, Murat Can, Gürsel Yıldız, and İsmail Özer
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Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Objective. Sulphur, similar to phosphorus, is easily attached to organic compounds. The inadequate elimination of sulphate may cause high sulphate concentrations in hemodialysis (HD) patients because sulphate is low in free form in plasma. Although we are well aware of the accumulation of phosphorus in chronic dialysis patients, we do not have an adequate knowledge database about the sulphur compounds. This study was designed to determine the level of sulphate in hemodialysis patients. Materials and Methods. Ninety-four prevalent HD patients and 33 patients without renal failure were included in the study. The serum inorganic sulphate levels were measured by turbidimetric technique. Moreover, the serum level of urea, creatinine, albumin, calcium, phosphorus, and parathyroid hormone concentrations was simultaneously recorded. Results. Mean levels of plasma sulphate were significantly higher (0.56 ± 0.17 mM vs 0.31 ± 0.13 mM, p
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- 2019
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5. The Effects of Vitamin D on Gentamicin-Induced Acute Kidney Injury in Experimental Rat Model
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Ender Hur, Alev Garip, Asuman Camyar, Sibel Ilgun, Melih Ozisik, Sena Tuna, Murat Olukman, Zehra Narli Ozdemir, Eser Yildirim Sozmen, Sait Sen, Fehmi Akcicek, and Soner Duman
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Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Introduction. Acute kidney injury (AKI) pathogenesis is complex. Findings of gentamicin nephrotoxicity are seen in 30% of the AKI patients. Vitamin D has proven to be effective on renin expression, inflammatory response, oxidative stress, apoptosis, and atherosclerosis. We aimed to investigate the effect of vitamin D in an experimental rat model of gentamicin-induced AKI. Methods. Thirty nonuremic Wistar albino rats were divided into 3 groups: Control group, 1 mL saline intramuscular (im) daily; Genta group, gentamicin 100 mg/kg/day (im); Genta + vitamin D, gentamicin 100 mg/kg/day (im) in addition to 1α, 25 (OH)2D3 0.4 mcg/kg/day subcutaneously for 8 days. Blood pressures and 24-hour urine were measured. Blood urea and creatinine levels and urine tubular injury markers were measured. Renal histology was semiquantitatively assessed. Results. Urea, creatinine and urine neutrophil gelatinase-associated lipocalin, and kidney injury molecule-1 were all increased in Genta group indicating AKI model. Systolic blood pressure decreased, but urine volume and glutathione increased in Genta + Vit D group compared to Control group. Histological scores indicating tubular injury increased in Genta and Genta + Vit D groups. Conclusions. Vitamin D does not seem to be effective on histological findings although it has some beneficial effects via RAS system and a promising effect on antioxidant system.
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- 2013
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6. Inflammatory Markers: C-Reactive Protein, Erythrocyte Sedimentation Rate, and Leukocyte Count in Vitamin D Deficient Patients with and without Chronic Kidney Disease
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Ibrahim Yildirim, Ender Hur, and Furuzan Kokturk
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Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Although some studies revealed a positive relationship between vitamin D3 deficiency and inflammatory markers, there have been also many studies that failed to find this relationship. The aim of this large scaled study is to determine the association between the level of plasma 25 hydroxy vitamin D3 [25-(OH) D3] and inflammatory markers in the general population without chronic kidney disease (CKD) and in patients with CKD. Participants with simultaneously measured inflammatory markers and 25-(OH) D3 levels were retrospectively analyzed (n=1897). The incidence of all-cause inflammation infection, hospitalization, chronic renal failure, and vitamin B12 deficiency was evaluated. The medians of serum creatinine levels in subjects without renal failure were lower in 25-(OH) D3 deficient group. Patients with CKD were more likely to have vitamin D3 deficiency compared with normal GFR. 25-(OH) D3 levels were associated with a greater incidence of all-cause hospitalization, hypoalbuminemia, and vitamin B12 deficiency. However, there was no relationship between inflammatory markers and vitamin D3 levels. In 25-(OH) D3 deficient patients, inflammatory markers can be related to other inflammatory and infectious status such as malnutrition and cachexia. We believed that there must be a relationship between vitamin deficiency and inflammatory markers due to other causes than low 25-(OH) D3 status.
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- 2013
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7. Characteristics and outcomes of hospitalised older patients with chronic kidney disease and COVID‐19: A multicenter nationwide controlled study
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Numan Gorgulu, Ekrem Kara, Bulent Tokgoz, Dilek Guven Taymez, Halil Zeki Tonbul, Ender Hur, Murside Esra Dolarslan, İrem Pembegül, Mustafa Arici, Zubeyde Serhan Tuglular, İdris Şahin, Mahmud Islam, Alaattin Yildiz, Gülizar Şahin, Taner Basturk, Kenan Ates, Mehmet Riza Altiparmak, Zeki Aydin, Mahmut Gok, Hamad Dheir, Zeki Soypacaci, Serhat Karadag, Siren Sezer, Necmi Eren, Kenan Turgutalp, Garip Sahin, Ali Riza Odabas, Serkan Bakirdogen, Barış Döner, Mehmet Deniz Ayli, Tuba Elif Ozler, Melike Betul Ogutmen, Savas Ozturk, Erkan Sengul, RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kara, Ekrem, Pembegül, İrem, Ozturk, Savas, Turgutalp, Kenan, Arici, Mustafa, Gok, Mahmut, Islam, Mahmud, Altiparmak, Mehmet Riza, Aydin, Zeki, Doner, Baris, Eren, Necmi, Sengul, Erkan, Karadag, Serhat, Ozler, Tuba Elif, Dheir, Hamad, Pembegul, Irem, Taymez, Dilek Guven, Sahin, Garip, Bakirdogen, Serkan, Dolarslan, Murside Esra, Soypacaci, Zeki, Hur, Ender, Basturk, Taner, Ogutmen, Melike Betul, Gorgulu, Numan, Sahin, Idris, Ayli, Mehmet Deniz, Tuglular, Zubeyde Serhan, Sahin, Gulizar, Tokgoz, Bulent, Tonbul, Halil Zeki, Yildiz, Alaattin, Sezer, Siren, Odabas, Ali Riza, and Ates, Kenan
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Nephrology ,HEMODIALYSIS ,medicine.medical_treatment ,kidney disease ,Renal-diasease ,030204 cardiovascular system & hematology ,law.invention ,0302 clinical medicine ,COVID-19 Testing ,law ,Risk Factors ,INFECTION ,030212 general & internal medicine ,POPULATION ,RISK ,Mortality rate ,Hazard ratio ,DEATH ,General Medicine ,Middle Aged ,Intensive care unit ,Original Papers ,Death ,Hospitalization ,Hemodialysis ,Female ,Covid-19 ,Infection ,Risk ,medicine.medical_specialty ,Population ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,Mortality ,Renal Insufficiency, Chronic ,Aged ,Retrospective Studies ,Original Paper ,business.industry ,SARS-CoV-2 ,MORTALITY ,COVID-19 ,Retrospective cohort study ,medicine.disease ,Confidence interval ,RENAL-DISEASE ,business ,Renal-Disease ,Kidney disease - Abstract
Objective Older adults with co‐morbidities have been reported to be at higher risk for adverse outcomes of coronavirus disease 2019 (COVID‐19). The characteristics of COVID‐19 in older patients and its clinical outcomes in different kidney disease groups are not well known. Methods Data were retrieved from a national multicentric database supported by Turkish Society of Nephrology, which consists of retrospectively collected data between 17 April 2020 and 31 December 2020. Hospitalised patients aged 18 years or older with confirmed COVID‐19 diagnosis suffering from stage 3‐5 chronic kidney disease (CKD) or on maintenance haemodialysis (HD) treatment were included in the database. Non‐uraemic hospitalised patients with COVID‐19 were also included as the control group. Results We included 879 patients [388 (44.1%) female, median age: 63 (IQR: 50‐73) years]. The percentage of older patients in the CKD group was 68.8% (n = 188/273), in the HD group was 49.0% (n = 150/306) and in the control group was 30.4% (n = 70/300). Co‐morbidities were higher in the CKD and HD groups. The rate of presentation with severe‐critical disease was higher in the older CKD and HD groups (43.6%, 55.3% and 16.1%, respectively). Among older patients, the intensive care unit (ICU) admission rate was significantly higher in the CKD and HD groups than in the control group (38.8%, 37.3% and 15.7%, respectively). In‐hospital mortality or death and/or ICU admission rates in the older group were significantly higher in the CKD (29.3% and 39.4%) and HD groups (26.7% and 30.1%) compared with the control group (8.6% and 17.1%). In the multivariate analysis, in‐hospital mortality rates in CKD and HD groups were higher than control group [hazard ratio (HR): 4.33 (95% confidence interval [CI]: 1.53‐12.26) and HR: 3.09 (95% CI: 1.04‐9.17), respectively]. Conclusion Among older COVID‐19 patients, in‐hospital mortality is significantly higher in those with stage 3‐5 CKD and on maintenance HD than older patients without CKD regardless of demographic characteristics, co‐morbidities, clinical and laboratory data on admission.
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- 2021
8. New Method to Predict Survival in Hemodialysis Patients Using the Impedance Ratio
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Ender Hur, Gürsel Yildiz, Elif Duman, Sennur Kose, Cenk Gokalp, Kemal Magden, Bilal Toka, Siren Sezer, Soner Duman, Ege Üniversitesi, and Zonguldak Bülent Ecevit Üniversitesi
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Transplantation ,medicine.medical_specialty ,hemodialysis ,Bioimpedance ,business.industry ,medicine.medical_treatment ,[No Keywords] ,impedance ratio ,survival ,0-Belirlenecek ,Nephrology ,Internal medicine ,Cardiology ,medicine ,Surgery ,Hemodialysis ,business ,Electrical impedance - Abstract
WOS: 000461206800006, Objective: Bioimpedance spectroscopy (BIS) can be used to determine hypervolemia and malnutrition in chronic hemodialysis (HD) patients. In this prospective observational study, we investigated the survival predictability of impedance ratio (IR) calculated by BIS in HD patients (Clinical Trials Gov Identifier: NCT01468363). Materials and Methods: A total of 430 chronic HD patients, out of 500 prevalent chronic HD patients from the city of Zonguldak who met the inclusion criteria, were included in the study. With a mean follow-up of 32.2 +/- 14.4 months, BIS was performed in all patients. The IR percentage (IR%) was calculated by dividing the resistance values using the 200 kHz and 5 kHz impulses. Student's t-test, Cox regression analysis, and Kaplan-Meier survival analysis were performed, and a p
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- 2019
9. Determinants of mortality in a large group of hemodialysis patients hospitalized for COVID-19
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Ali Riza Odabas, Tuba Elif Ozler, Savas Ozturk, Ozkan Gungor, Yavuz Ayar, Ebru Gok Oguz, Bulent Tokgoz, Kenan Turgutalp, Mahmut Islam, Ilay Berke Mentes, Halil Zeki Tonbul, Rumeyza Kazancioglu, Ender Hur, Zeki Aydin, Bulent Demirelli, Erkan Sengul, Mustafa Arici, Numan Gorgulu, Tamer Sakaci, Bülent Huddam, Alaattin Yildiz, Kenan Ates, Mehmet Riza Altiparmak, Savas Sipahi, Necmi Eren, Siren Sezer, Sami Uzun, İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Altiparmak, Mehmet Riza, and KAZANCIOĞLU, Rümeyza
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Male ,medicine.medical_specialty ,Critical Care ,Turkey ,medicine.medical_treatment ,Clinical findings ,Radiological manifestations ,lcsh:RC870-923 ,law.invention ,Pulmonary Disease, Chronic Obstructive ,law ,Renal Dialysis ,Risk Factors ,Intensive care ,Internal medicine ,medicine ,Humans ,Hemodialysis ,COVID-19 ,Mortality ,Hospital Mortality ,Pandemics ,Survival analysis ,Aged ,Retrospective Studies ,Mechanical ventilation ,Heart Failure ,business.industry ,SARS-CoV-2 ,Mortality rate ,Retrospective cohort study ,Middle Aged ,medicine.disease ,lcsh:Diseases of the genitourinary system. Urology ,Intensive care unit ,Respiration, Artificial ,Hospitalization ,Radiography ,Nephrology ,Heart failure ,Kidney Failure, Chronic ,Female ,business ,Research Article - Abstract
Background Maintenance hemodialysis (MHD) patients are at increased risk for coronavirus disease 2019 (COVID-19). The aim of this study was to describe clinical, laboratory, and radiologic characteristics and determinants of mortality in a large group of MHD patients hospitalized for COVID-19. Methods This multicenter, retrospective, observational study collected data from 47 nephrology clinics in Turkey. Baseline clinical, laboratory and radiological characteristics, and COVID-19 treatments during hospitalization, need for intensive care and mechanical ventilation were recorded. The main study outcome was in-hospital mortality and the determinants were analyzed by Cox regression survival analysis. Results Of 567 MHD patients, 93 (16.3%) patients died, 134 (23.6%) patients admitted to intensive care unit (ICU) and 91 of the ones in ICU (67.9%) needed mechanical ventilation. Patients who died were older (median age, 66 [57–74] vs. 63 [52–71] years, p = 0.019), had more congestive heart failure (34.9% versus 20.7%, p = 0.004) and chronic obstructive pulmonary disease (23.6% versus 12.7%, p = 0.008) compared to the discharged patients. Most patients (89.6%) had radiological manifestations compatible with COVID-19 pulmonary involvement. Median platelet (166 × 103 per mm3 versus 192 × 103 per mm3, p = 0.011) and lymphocyte (800 per mm3 versus 1000 per mm3, p p = 0.001) on admission were lower in patients who died. Age (HR: 1.022 [95% CI, 1.003–1.041], p = 0.025), severe-critical disease clinical presentation at the time of diagnosis (HR: 6.223 [95% CI, 2.168–17.863], p p = 0.009), ferritin levels on admission (HR; 1.057 [95% CI, 1.006–1.111], p = 0.028), elevation of aspartate aminotransferase (AST) (HR; 3.909 [95% CI, 2.143–7.132], p 3 per mm3) during hospitalization (HR; 1.864 [95% CI, 1.025–3.390], p = 0.041) were risk factors for mortality. Conclusion Hospitalized MHD patients with COVID-19 had a high mortality rate. Older age, presence of heart failure, clinical severity of the disease at presentation, ferritin level on admission, decrease in platelet count and increase in AST level during hospitalization may be used to predict the mortality risk of these patients.
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- 2021
10. Green Hemodialysis: A Possible Way of Nature Friendly and Cost-Effective Kidney Replacement Therapy
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Ender Hür and Soner Duman
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Internal medicine ,RC31-1245 ,Pediatrics ,RJ1-570 - Published
- 2023
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11. SP028SCREENING THE FABRY DISEASE IN HEMODIALYSIS POPULATION: A MULTI-CENTERED STUDY
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Ozlem Yayar, Ender Hur, Siren Sezer, Huseyin Taskin, Davut Akin, Gürsel Yildiz, Çiğdem Dinçkal, Soner Duman, Oguzcan Ozkan, Emine Mercan, Barıs Emekdas, Funda Saglam, Eyup Kulah, and Yelda Gün
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Transplantation ,Pediatrics ,medicine.medical_specialty ,education.field_of_study ,business.industry ,medicine.medical_treatment ,Population ,Geographic population ,medicine.disease ,Fabry disease ,Nephrology ,medicine ,Hemodialysis ,education ,business - Published
- 2019
12. Risk Factors for Catheter Related Central Venous Thrombosis in Hemodialysis Patients
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Cem Çil, Ender Hur, Furuzan Kokturk, Bilal Toka, Nesimi Yavuz, Ibrahim Yildirim, Gürsel Yildiz, Kemal Magden, and Zonguldak Bülent Ecevit Üniversitesi
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Transplantation ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,anti-coagulant drug usage ,medicine.disease ,Surgery ,Venous thrombosis ,Catheter ,Nephrology ,Permanent hemodialysis catheter ,medicine ,Hemodialysis ,business ,thrombosis - Abstract
WOS: 000461206800010, Objective: Permanent catheters are used for vascular access in some patients undergoing hemodialysis (HD). Our aim in this study was to evaluate the risk factors of permanent catheter thrombosis and the necessity of anti-coagulant and anti-aggregation drugs. Materials and Methods: In this retrospective study, 34 patients undergoing HD, with removed internal jugulary permanent catheters due to either thrombosis or maturation of operated arteriovenous fistulas, were included. Patients were divided into thrombotic and non-thrombotic, according to the catheter thrombosis status. Results: The mean age was 66.3 +/- 15.4 years, and the follow-up period was 10.9 +/- 8.5 (1-29) months. Catheter thrombosis was found in 12 patients. Albumin and total protein levels were lower in the baseline thrombotic group (3.53 +/- 0.46 g/dL and 6.64 +/- 0.92g/dL, respectively) than in the non-thrombotic group (3.95 +/- 0.41 and 7.37 +/- 0.46g/dL, respectively). In the non-thrombotic group, hemoglobin, hematocrit higher, and platelet count were lower at the catheter removal time compared to the catheter insertion time (hemoglobin 11.45 +/- 1.25, hematocrit 35.61 +/- 4.51, and platelet count 193.82 +/- 66.32 versus hemoglobin 10.33 +/- 1.37g/dL, hematocrit 31.38 +/- 3.79% and platelet count 231.77 +/- 71.7x103/uL, respectively), but in the thrombotic group, the ferritin levels significantly increased from 541.3 +/- 574.8ng/mL at the catheter insertion time to 745.1 +/- 406.5ng/mL at the catheter removal time. Conclusion: Anti-coagulant and anti-aggregation drugs and renal failure etiology did nothave any effect on permanent catheter thrombosis, but the albumin and total protein levels were related to it. Increased levels of ferritin and C-reactive protein seem to emerge as the acute phase reactants associated with thrombosis.
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- 2019
13. Serum Sulphate Levels in Hemodialysis Patients
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Kemal Magden, Gürsel Yildiz, Ender Hur, Murat Can, Ibrahim Yildirim, Sevil Uygun Ilikhan, Ismail Ozer, and Hüseyin Engin
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medicine.medical_specialty ,Creatinine ,biology ,Article Subject ,business.industry ,medicine.medical_treatment ,Phosphorus ,Albumin ,Serum albumin ,Parathyroid hormone ,chemistry.chemical_element ,Calcium ,lcsh:Diseases of the genitourinary system. Urology ,lcsh:RC870-923 ,Gastroenterology ,chemistry.chemical_compound ,chemistry ,Nephrology ,Internal medicine ,medicine ,biology.protein ,Urea ,Hemodialysis ,business ,Research Article - Abstract
Objective. Sulphur, similar to phosphorus, is easily attached to organic compounds. The inadequate elimination of sulphate may cause high sulphate concentrations in hemodialysis (HD) patients because sulphate is low in free form in plasma. Although we are well aware of the accumulation of phosphorus in chronic dialysis patients, we do not have an adequate knowledge database about the sulphur compounds. This study was designed to determine the level of sulphate in hemodialysis patients.Materials and Methods. Ninety-four prevalent HD patients and 33 patients without renal failure were included in the study. The serum inorganic sulphate levels were measured by turbidimetric technique. Moreover, the serum level of urea, creatinine, albumin, calcium, phosphorus, and parathyroid hormone concentrations was simultaneously recorded.Results. Mean levels of plasma sulphate were significantly higher (0.56 ± 0.17 mM vs 0.31 ± 0.13 mM,p<0.001) in HD patients. Serum sulphate level correlated with patient’s age, serum albumin, serum BUN and creatinine, and serum phosphorus level in HD patients. Serum sulphate levels were not associated with serum parathyroid hormone levels.Conclusion. Serum sulphate levels were approximately twofold higher in HD patients than in the normal control group. Inorganic sulphate does not seem to accumulate in long-term dialysis patients, and mild increased serum levels of sulphate has no poor clinical outcome in these patients.
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- 2019
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14. The Relationship Between Bioimpedance-Measured Volume and Nutritional Parameters and Mortality in Hemodialysis Patients
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U Soyaltın, A Sivri, Ender Hur, N Turan, S Köse Budak, S Çelikörs, Siren Sezer, Gürsel Yildiz, B Altundal, Bilal Toka, Abdulkerim Yilmaz, Kemal Magden, Soner Duman, A Tunç, and Zonguldak Bülent Ecevit Üniversitesi
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medicine.medical_specialty ,Bioimpedance ,business.industry ,Urology ,medicine.medical_treatment ,Malnutrition ,Overhydration ,030232 urology & nephrology ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Volume (thermodynamics) ,Internal medicine ,Cardiology ,Medicine ,Surgery ,Hemodialysis ,Mortality ,business ,Fat tissue index - Abstract
OBJECTIVE: Hypervolemia and malnutrition are often undiagnosed risk factors for hemodialysis (HD). Our aim was to investigate the long-term effects of hypervolemia and malnutrition evaluated by bioimpedance spectroscopy (BIS) on survival. (Clinical Trials. Gov Identifier: NCT01468363). MATERIAL and METHODS: A total of 431 Prevalent HD patients were followed for 32.2±14.4 months. The patients underwent BIS measurement, a medical history was obtained, and routine tests were analyzed at the baseline and at the end of the study. Hospitalizations and complications of HD were recorded. RESULTS: The mean age was 59.4±14.6 (10-92) years with a total of 431 (53.6% males) patients of which 125 died. The percentage of diabetics was 47%, erythropoietin use 67%, and diuretic use 40%. Predialysis systolic blood pressure (BP) was 133.4±25.8 and diastolic BP 79.2±12.4 mm Hg. The rate of diabetes, and the number of hospitalizations and blood transfusions were higher in the patients who died. Diastolic BP as a clinical hypervolemia finding, BIS hypervolemia indicator of over hydration (OH), and extracellular water (ECW) were all increased, and fat tissue index as a malnutrition finding was decreased in patients who died. There were significant rates of anemia and hypoalbuminemia in this group as well. The cumulative survival was lower in hypervolemic patients as assessed by relative hydration status OH/ECW. CONCLUSION: Hypervolemia and malnutrition are the long-term mortality indicators in hemodialysis. Early diagnosis and treatment is important. Clinical findings may not be sufficient and laboratory and BIS methods can be used for diagnosis.
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- 2017
15. Volume and Nutritional Status Evaluated by Bioimpedance Affected by Body Positions
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Cihan Ural, Kemal Magden, Kenan Ates, Soner Duman, Fehmi Akcicek, Gultekin Suleymanlar, Gürsel Yildiz, Ender Hur, Ibrahim Yildirim, Melih Özişik, Ali Basci, Sennur Kose, and Zonguldak Bülent Ecevit Üniversitesi
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Bioimpedance spectroscopy ,Volume (thermodynamics) ,business.industry ,Urology ,Overhydration ,Body position ,Extracellular water ,Physiology ,Medicine ,Surgery ,Nutritional status ,business ,Fluid shift - Abstract
Objective: Body composition analysis is useful technique for assessing hydration, nutritional status and predicting clinical outcomes. Bioimpedance analysis (BIA) is a cheap and noninvasive tool for monitoring body composition but needs some improvements regarding measurement methods. We aimed to find out if body position has an effect on the BIA results. Material and Methods: Personal characteristics including age, gender, height, weight and blood pressure were recorded. Hydration and nutritional status measured by body composition monitor in supine and standing positions consequently for each individual. Results: Two hundred and one populations from various region in Turkey, 61% (n: 123) male, mean age was 46.3±12 years (18-76) of age, participated in this crossectional study. From supine to standing positions overhydration and extracellular water (ECW) were increased from 0.04±1.08 and 17.69±2.92 to 0.46±1.05 L and 17.84±2.90 L while intracellular water (ICW) decreased from 22.55±4.35 to 22.04±4.28 L significantly. Systolic and diastolic blood pressures were 131.3±18.1 and 75.1±12 decreased to 127.0±16.0 and 72.2±9.0 mmHg in supine to standing positions (p> 0.05). Conclusion: Supine and standing positions could affect the volume parameters of BIA due to shift of ECW and ICW by gravity but nutritional parameters also changes significantly. Protocols should be re evaluated in order to get more accurate results in bioimpedance measurements.
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- 2014
16. The effects of strict salt control on blood pressure and cardiac condition in end-stage renal disease: prospective-study
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Muhammet Rasit Sayin, Ender Hur, Sennur Kose, Selahattin Bicak, Kemal Magden, Soner Duman, Ibrahim Yildirim, Gürsel Yildiz, and Zonguldak Bülent Ecevit Üniversitesi
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Adult ,medicine.medical_specialty ,medicine.medical_treatment ,Blood Pressure ,Critical Care and Intensive Care Medicine ,Left ventricular hypertrophy ,End stage renal disease ,Peritoneal dialysis ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Aged ,Hypervolemia ,business.industry ,General Medicine ,Diet, Sodium-Restricted ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Blood pressure ,Endocrinology ,Nephrology ,Hypertension ,Cardiology ,Kidney Failure, Chronic ,Abdomen ,Hypertrophy, Left Ventricular ,Cardiac condition ,Strict salt control ,Hemodialysis ,business - Abstract
Introduction: Overhydration is the main contributory factor of left ventricular hypertrophy and closely associated with cardiovascular events in end stage renal disease (ESRD) patients. The aim of this prospective-study was to investigate the impact of strict salt and volume control on hypertension and cardiac condition in ESRD patients. Methods: A total of 12 peritoneal dialysis (PD) and 15 prevalent hemodialysis (HD) patients were enrolled. All patients either PD or HD were allocated to intervention of strict salt restriction according to basal hydration state of empty abdomen in PD and midweek predialysis HD which were estimated by body composition monitor (BCM) and echocardiography. Results: Mean ages were 48.3±16.7 years for PD, and 48.8±18 for HD patients. Extracellular water/height was 10.04±2.70 and 10.39±1.53L/m in PD and HD groups. Systolic blood pressures decreased in PD and HD from 133.1±28 and 147.3±28.5 to 114.8±16.5 and 119.3±12.1mmHg, respectively, (p0.05). LVMI and LAI were not increased in both groups. Conclusion: Strict salt and volume control in ESRD patients after assessment of hydration status with either using BCM or echocardiography provides better management of volume control leading to more precise cardiovascular protection. © 2013 Informa Healthcare USA, Inc.
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- 2013
17. Effect of Fluid Management Guided by Bioimpedance Spectroscopy on Cardiovascular Parameters in Hemodialysis Patients: A Randomized Controlled Trial
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Soner Duman, Mehmet Usta, Serdar Kahvecioglu, Peter Wabel, Gulay Asci, Mehmet Ozkahya, Ender Hur, Ercan Ok, Meltem Sezis Demirci, Meral Kayıkçıoğlu, and Huseyin Toz
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Adult ,Male ,medicine.medical_specialty ,Ambulatory blood pressure ,medicine.medical_treatment ,Body water ,Water-Electrolyte Imbalance ,Left ventricular hypertrophy ,Vascular Stiffness ,Body Water ,Renal Dialysis ,Internal medicine ,Humans ,Medicine ,Longitudinal Studies ,Dialysis ,Ultrasonography ,business.industry ,Middle Aged ,medicine.disease ,Hemodialysis Solutions ,Surgery ,Treatment Outcome ,Blood pressure ,Nephrology ,Dielectric Spectroscopy ,Hypertension ,Cardiology ,Arterial stiffness ,Female ,Hypertrophy, Left Ventricular ,Hemodialysis ,business ,Hypervolemia - Abstract
Background Fluid overload is the main determinant of hypertension and left ventricular hypertrophy in hemodialysis patients. However, assessment of fluid overload can be difficult in clinical practice. We investigated whether objective measurement of fluid overload with bioimpedance spectroscopy is helpful in optimizing fluid status. Study Design Prospective, randomized, and controlled study. Setting & Participants 156 hemodialysis patients from 2 centers were randomly assigned to 2 groups. Intervention Dry weight was assessed by routine clinical practice and fluid overload was assessed by bioimpedance spectroscopy in both groups. In the intervention group (n = 78), fluid overload information was provided to treating physicians and used to adjust fluid removal during dialysis. In the control group (n = 78), fluid overload information was not provided to treating physicians and fluid removal during dialysis was adjusted according to usual clinical practice. Outcomes The primary outcome was regression of left ventricular mass index during a 1-year follow-up. Improvement in blood pressure and left atrial volume were the main secondary outcomes. Changes in arterial stiffness parameters were additional outcomes. Measurements Fluid overload was assessed twice monthly in the intervention group and every 3 months in the control group before the mid- or end-week hemodialysis session. Echocardiography, 48-hour ambulatory blood pressure measurement, and pulse wave analysis were performed at baseline and 12 months. Results Baseline fluid overload parameters in the intervention and control groups were 1.45 ± 1.11 (SD) and 1.44 ± 1.12 L, respectively ( P = 0.7). Time-averaged fluid overload values significantly decreased in the intervention group (mean difference, −0.5 ± 0.8 L), but not in the control group (mean difference, 0.1 ± 1.2 L), and the mean difference between groups was −0.5 L (95% CI, −0.8 to −0.2; P = 0.001). Left ventricular mass index regressed from 131 ± 36 to 116 ± 29 g/m 2 ( P 2 ; P = 0.9); mean difference between groups was −10.2 g/m 2 (95% CI, −19.2 to −1.17 g/m 2 ; P = 0.04). In addition, values for left atrial volume index, blood pressure, and arterial stiffness parameters decreased in the intervention group, but not in the control group. Limitations Ambulatory blood pressure data were not available for all patients. Conclusions Assessment of fluid overload with bioimpedance spectroscopy provides better management of fluid status, leading to regression of left ventricular mass index, decrease in blood pressure, and improvement in arterial stiffness.
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- 2013
18. Increased arterial stiffness in patients with nephrotic syndrome
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Ender Hur, Sait Şen, Savas Sipahi, Fatih Kircelli, Ercan Ok, Erhan Tatar, Ali Basci, Ozkan Gungor, Huseyin Toz, Meltem Sezis Demirci, Gungor, O, Demirci, MS, Kircelli, F, Tatar, E, Sipahi, S, Hur, E, Sen, S, Toz, H, Basci, A, Ok, E, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, and Sipahi, Savaş
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Adult ,Male ,medicine.medical_specialty ,Mean arterial pressure ,Nephrotic Syndrome ,Adolescent ,Turkey ,Renal function ,Young Adult ,Vascular Stiffness ,Internal medicine ,medicine ,Humans ,Arterial Pressure ,Aged ,Body surface area ,business.industry ,Incidence ,General Medicine ,Middle Aged ,medicine.disease ,Pulse pressure ,Femoral Artery ,Carotid Arteries ,Cross-Sectional Studies ,Blood pressure ,Nephrology ,Hypertension ,Arterial stiffness ,Cardiology ,Female ,business ,Bioelectrical impedance analysis ,Body mass index ,Blood Flow Velocity - Abstract
Introduction: Nephrotic syndrome (NS) and arterial stiffness (AS) have each been linked with increased risk for cardiovascular diseases. However, there is no data in the literature up-to-date on AS in adult patients with NS. Thus, in this study, we aimed to evaluate the potential associations between AS, volume and nutritional status in patients with NS in comparison to a healthy control group. Methods: 34 adult patients with newly diagnosed but untreated NS and 34 healthy controls were studied. AS was assessed by carotid-femoral PWV (cf-PWV) and body composition, nutritional status by multi-frequency bioelectric impedance analysis (BIA). Results: Mean age was 44.6 +/- 18.7 years (18 - 72). Mean cf-PWV was 8.3 +/- 2.5 m/s in patients with NS and 6.7 +/- 1.1 m/s in controls (p = 0.002). In univariate analysis, cf-PWV and positively correlated with age, systolic blood pressure, mean arterial pressure (MAP), pulse pressure, body mass index, body fat ratio, waisthip ratio, creatinine, uric acid and negatively with creatinine clearance. In linear regression analysis, only age and MAP predicted arterial stifffiess. Total body fluid, extracellular water (ECW), ECW/Height, ECW/body surface area and third space volumes were higher in patients with NS. Conclusion: Patients with NS have increased AS and are more hypervolemic compared to the healthy subjects.
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- 2013
19. Effect of octreotide on oxidative stress in the erythrocyte and kidney tissue in adriamycin-induced experimental nephrotic syndrome model
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Sibel Cavdar, Alev Garip Acar, Asuman Camyar, Ender Hür, Eser Yıldırım Sozmen, Sait Sen, Melih Ozısık, Yasemin Delen Akcay, Elif Duman, Sena Gönen, Fehmi Akcicek, and Soner Duman
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Nephrotic Syndrome ,Octreotide ,Reactive Oxygen Species ,Catalase ,Thiobarbituric Acid Reactive Substance ,Oxidative Stress ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Introduction: Nephrotic syndrome (NS) is one of the reasons of end-stage kidney disease, and elucidating the pathogenesis and offer new treatment options is important. Oxidative stress might trigger pathogenesis systemically or isolated in the kidneys. Octreotide (OCT) has beneficial antioxidant effects. We aimed to investigate the source of oxidative stress and the effect of OCT on experimental NS model. Methods: Twenty-four non-uremic Wistar albino rats were divided into 3 groups. Control group, 2 mL saline intramuscular (im); NS group, adriamycin 5 mg/kg intravenous (iv); NS treatment group, adriamycin 5 mg/kg (iv) and OCT 200 mcg/kg (im) were administered at baseline (Day 0). At the end of 21 days, creatinine and protein levels were measured in 24-hour urine samples. Erythrocyte and renal catalase (CAT) and thiobarbituric acid reactive substance (TBARS) were measured. Renal histology was also evaluated. Results: There was no significant difference among the 3 groups in terms of CAT and TBARS in erythrocytes. Renal CAT level was lowest in NS group, and significantly lower than the control group. In treatment group, CAT level significantly increased compared with NS group. In terms of renal histology, tubular and interstitial evaluations were similar in all groups. Glomerular score was significantly higher in NS group compared with control group and it was significantly decreased in treatment group compared to NS group. Conclusions: Oxidative stress in NS might be due to the decrease in antioxidant protection mechanism in kidney. Octreotide improves antioxidant levels and histology in renal tissue and might be a treatment option.
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- 2023
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20. Türk hemodiyaliz hasta popülasyonunda hiperparatiroidizm tedavisinde Sinakalset’in etkinliği
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Özkan Ulutaş, Ibrahim Dogan, Mehmet Tanrisev, Necmi Eren, Ayten Oğuz, Abdulmecit Yildiz, Kultigin Turkmen, Sibel Ada, Elif Arı, Orcun Altunoren, Ender Hur, Ismail Kocyigit, Ahmet Korkmaz, Serkan Bakirdogen, Ayper Azak, Mehmet Sert, Funda Saglam, Mehmet Nuri Turan, İrem Pembegül, Yasemin Coşkun Yavuz, Sennur Kose, Aydın Güçlü, Demet Yavuz, Ferhan Aytuğ, Mustafa Yaprak, Bülent Akgül, Mahmut Ilker Yilmaz, Ozkan Gungor, Hikmet Tekce, Osman Zikrullah Sahin, Tamer Sakacı, Bülent Kaya, RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Şahin, Osman Zikrullah, and Hitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
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Pediatrics ,medicine.medical_specialty ,Hyperparathyroidism ,Cinacalcet ,Turkish ,business.industry ,Urology ,medicine.medical_treatment ,medicine.disease ,Parathormone ,language.human_language ,Patient population ,Secondary hyperparathyroidism ,Hemodialysis ,medicine ,language ,Chronic renal failure ,Surgery ,business ,Secondary Hyperparathyroidism ,Chronic Renal Failure ,medicine.drug - Abstract
WOS: 000393291900012 OBJECTIVE: Cinacalcet reduces parathyroid hormone levels by increasing the sensitivity of the parathyroid gland to calcium. in this study, we firstly aimed to evaluate the efficacy of cinacalcet in Turkish hemodialysis patients. MATERIAL and METHODS: 4483 hemodialysis patients were screened and 469 patients who had used cinacalcet were included in the study. the patients were divided into 4 groups according to drug usage durations (Group 1: 3 months, Group 2: 6 months, Group 3: 9 months and Group 4: 12 months). the patients' Parathormone, Ca, P and CaxP levels at the 3rd, 6th, 9th and 12th months were compared to the start of treatment and previous months. RESULTS: the levels of Parathormone, Ca, P and CaxP significantly decreased compared to their initial levels in all groups (from 1412 pg/ml to 1222 pg/mL for Parathormone, p< 0,001) in the 3rd month. However, this reduction was not continued in the subsequent months (Parathormone: 1381 pg/ml for the 12th month). CONCLUSION: Cinacalcet may not provide adequate benefit in control of hyperparathyroidism in Turkish hemodialysis patient population.
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- 2016
21. The Mean Platelet Volume and Atherogenic Index of Plasma in Nondipper Normotensive Individuals Compared to Dippers
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Ender Hur, Adalet Ozcicek, Mansur Kayataş, Gürsel Yildiz, Ferhan Candan, Zonguldak Bülent Ecevit Üniversitesi, [Yildiz, Gursel] Ataturk State Hosp, Clin Nephrol, Zonguldak, Turkey -- [Hur, Ender] Karaelmas Univ, Dept Internal Med, Div Nephrol, Sch Med, Zonguldak, Turkey -- [Ozcicek, Adalet] Erzincan Univ, Sch Med, Dept Internal Med, Erzincan, Turkey -- [Candan, Ferhan -- Kayatas, Mansur] Cumhuriyet Univ, Sch Med, Div Nephrol, Dept Internal Med, Sivas, Turkey, and hur, ender -- 0000-0002-8066-4629
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Adult ,Blood Platelets ,Male ,medicine.medical_specialty ,Physiology ,Mean platelet volume ,Blood Pressure ,Positive correlation ,chemistry.chemical_compound ,Risk Factors ,dippers ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Platelet activation ,Triglycerides ,mean platelet volume ,normotensive ,Cholesterol ,business.industry ,Cholesterol, HDL ,Atherogenic index of plasma ,Case-control study ,atherogenic index of plasma ,General Medicine ,Plasma levels ,Middle Aged ,Atherosclerosis ,Platelet Activation ,Nocturnal blood pressure ,Circadian Rhythm ,nondippers ,Endocrinology ,chemistry ,Case-Control Studies ,Female ,Nondippers ,business ,Dippers ,Biomarkers ,Normotensive ,Lipoprotein - Abstract
WOS: 000312869700007, PubMed ID: 22630818, Mean platelet volume (MPV) is a determinant of platelet activation. Atherogenic index of plasma (AIP), which is defined as the logarithm of the ratio of plasma level of triglycerides to the level of high-density lipoprotein (HDL)-cholesterol (log[TG/HDL-C]), has recently been used as a marker of atherogenicity. This study included 104 normotensive individuals. Mean platelet volume and AIP were measured in all patients. Nondipper individuals (8.6 +/- 0.9 fL, 0.3 +/- 0.2) demonstrated higher values of MPV and AIP compared with dippers (7.9 +/- 1.1 fL, 0.1 +/- 0.2) (P
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- 2012
22. Bioimpedance Spectroscopy for the Detectıon of Hypervolemia in Hemodialysis Patients
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Meltem Sezis Demirci, Ender Hur, Serdar Kahvecioglu, Soner Duman, Ercan Ok, Mehmet Usta, Ozkan Gungor, Latife Meral Kayikcioglu, Huseyin Toz, and Gulay Asci
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medicine.medical_specialty ,Bioimpedance spectroscopy ,business.industry ,Urology ,Internal medicine ,medicine.medical_treatment ,medicine ,Cardiology ,Surgery ,Hemodialysis ,Hypervolemia ,medicine.disease ,business - Published
- 2011
23. Octreotide lessens peritoneal injury in experimental encapsulated peritoneal sclerosis model
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Savas Sipahi, Soner Duman, Muhittin Ertilav, Ender Hur, Banu Sarsik, Ozge Timur, Fehmi Akcicek, and Devrim Bozkurt
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Monocyte ,Octreotide ,Inflammation ,General Medicine ,medicine.disease ,Gastroenterology ,Peritoneal dialysis ,Vascular endothelial growth factor ,chemistry.chemical_compound ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Peritoneum ,Nephrology ,Fibrosis ,Internal medicine ,medicine ,medicine.symptom ,business ,Saline ,medicine.drug - Abstract
Aim: Encapsulated peritoneal sclerosis is characterized by neoangiogenesis and fibrosis. Octreotide, a somatostatin analogue is a well-known antifibrotic, antiproliferative and anti-angiogenic agent. The aim of the study is to evaluate the effects of octreotide in encapsulated peritoneal sclerosis-induced neoangiogenesis and fibrosis and compare the results with resting. Methods: Non-uraemic Wistar-Albino male rats (n = 35) were divided into four groups. Group I, control rats, received 2 mL isotonic saline i.p. daily for 3 weeks. Group II, received daily i.p. 2 mL/200 g injection of chlorhexidine gluconate (0.1%) and ethanol (%15) dissolved in saline for 3 weeks. Group III, chlorhexidine gluconate for 3 weeks plus an additional 3 weeks without any treatment (rest), to a total of 6 weeks. Group IV, chlorhexidine gluconate for 3 weeks plus an additional 3 weeks octreotide, 50 mcg/kg bodyweight s.c., for a total of 6 weeks. Results: Octreotide significantly reversed ultrafiltration capacity of peritoneum with decreasing inflammation, neoangiogenesis and fibrosis compared to the resting group. Octreotide also caused inhibition of dialysate transforming growth factor-β1, vascular endothelial growth factor and monocyte chemotactic protein-1 activity and improved mesothelial cell cytokeratin expression. Peritoneal resting has no beneficial effects on peritoneum. Conclusion: In conclusion, octreotide may have a therapeutic value in peritoneal dialysis patients who suffer from encapsulated peritoneal sclerosis.
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- 2011
24. Octreotide May Prevent Ultrafi ltration Failure in Experimental Peritonitis Model
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Ender Hur, Bilgin Arda, Soner Duman, Can Duman, Savas Sipahi, Fehmi Akcicek, Devrim Bozkurt, Muhittin Ertilav, Ali Basci, and Sait Şen
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medicine.medical_specialty ,business.industry ,Urology ,Internal medicine ,medicine ,Octreotide ,Surgery ,business ,Gastroenterology ,Experimental peritonitis ,medicine.drug - Published
- 2011
25. Progression of graft fibrosis under mammalian target of rapamycin inhibitor-based regimen
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Funda Tasli, Cuneyt Hoscoskun, Mümtaz Yilmaz, Adam Uslu, Mehmet Ozkahya, Huseyin Toz, Ender Hur, Ahmet Nart, and Sait Şen
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medicine.medical_specialty ,Everolimus ,medicine.diagnostic_test ,business.industry ,General Medicine ,medicine.disease ,Gastroenterology ,Nephrotoxicity ,Surgery ,Calcineurin ,Regimen ,Nephrology ,Fibrosis ,Internal medicine ,Sirolimus ,Biopsy ,medicine ,business ,Kidney transplantation ,medicine.drug - Abstract
Aim: Nephrotoxic potential of mammalian target of rapamycin inhibitors (mTORi) is different from calcineurin inhibitors (CNI). The aim of this study is to investigate the interstitial fibrosis (ci) and tubular atrophy (ct) progression from the baseline to first year under a mTORi-based, CNI-free regimen. Methods: Thirty-five kidney transplant recipients who had to have adequate baseline and first year protocol biopsy were enrolled. Exclusion criteria were: the replacement of CNI at any time; acute deterioration in allograft functions; and serum creatinine level above 3 mg/dL at 12 months. Banff criteria were used for histopathological classification. Progression was defined as delta ci + ct ≥ 2 (difference between 12th month and baseline). Results: Mean age of patients and donors were 34 ± 11 and 49 ± 10 years. Twelve patients had delayed graft function (DGF). The maintenance regimen consisted of sirolimus (n = 24) and everolimus (n = 11) with mycophenolate mofetil and steroids. Incidence of acute rejection was 25.7%. At baseline, the incidence of nil and mild fibrosis were 80% and 20%, respectively. At 12 months, 17.1% of patients had moderate, 40% had mild and 42.9% had nil fibrosis. Histological progression from baseline to first year was present in 34% of patients. In multivariate analysis the presence of DGF (P = 0.018) and deceased donor type (P = 0.011) were the most important predictors for fibrosis progression. Conclusion: Progression of graft fibrosis may be seen in one-third of patients under a mTORi-based regimen particularly manifested in deceased donor recipients with subsequent DGF.
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- 2010
26. SP672DETERMINING THE FEASIBILITY OF NUTRITIONAL SCREENING TESTS IN HEMODIALYSIS PATIENTS
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Gizem Taban, Cenk Gokalp, Malkoc Malkoc, Fugen Bayrak, Ender Hur, Özge Küçükerdönmez, Huseyin Taskin, Ibrahim Keskin, Soner Duman, and Ilhan Akgungor
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Transplantation ,medicine.medical_specialty ,Screening test ,Nephrology ,business.industry ,medicine.medical_treatment ,Emergency medicine ,medicine ,Hemodialysis ,business - Published
- 2018
27. Does Immunosuppressive Treatment Ameliorate Morphology Changes in Encapsulating Peritoneal Sclerosis?
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Ender Hur, Pinar Cetin, Devrim Bozkurt, Savas Sipahi, Muhittin Ertilav, Özden Özdemir, Sait Şen, Soner Duman, Bozkurt, D, Sipahi, S, Cetin, P, Hur, E, Ozdemir, O, Ertilav, M, Sen, S, Duman, S, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Sipahi, Savaş, and Duman, Soner
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medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Azathioprine ,Peritoneal Diseases ,Gastroenterology ,Peritoneal dialysis ,Subcutaneous injection ,Fibrosis ,Internal medicine ,medicine ,Animals ,Rats, Wistar ,Glucocorticoids ,Saline ,Immunosuppression Therapy ,Sclerosis ,Dose-Response Relationship, Drug ,business.industry ,General Medicine ,medicine.disease ,Pathophysiology ,Rats ,Surgery ,Disease Models, Animal ,Treatment Outcome ,Nephrology ,Cyclosporine ,Prednisolone ,Corticosteroid ,Female ,Peritoneum ,business ,Peritoneal Dialysis ,Immunosuppressive Agents ,medicine.drug - Abstract
Encapsulating peritoneal sclerosis (EPS) is a clinical syndrome associated with ileus symptoms and irreversible sclerosis of the peritoneal membrane. Inflammation, fibrosis, and neoangiogenesis are the main features of the pathophysiology. No evidence-based therapy is currently available for EPS. In recent years, anti-inflammatory and immunosuppressive (IS) treatment modalities have become more popular. The aim of the present study was to investigate the effects of various IS treatment strategies—glucocorticosteroid (GC), azathiopurine (AZT), and cyclosporin (CsA)—on regression of EPS. We divided 52 nonuremic Wistar albino rats into six groups: Control group—2 mL isotonic saline injected intraperitoneally (IP) daily for 3 weeks; CG group—2 mL/200 g 0.1% chlorhexidine gluconate (CG) and 15% ethanol dissolved in saline injected IP daily for 3 weeks; Resting group—CG (weeks 1 – 3), plus peritoneal rest (weeks 4 – 6); Corticosteroid (GC) group—CG (weeks 1 – 3), plus 10 mg/L prednisolone in drinking water (weeks 4 – 6); AZT group—CG (weeks 1 – 3), plus 100 mg/L azathioprine in drinking water (weeks 4 – 6); and CsA group—CG (weeks 1 – 3), plus cyclosporin 7.5 mg/kg by subcutaneous injection daily (weeks 4 – 6). At the end of the study, under ketamine HCl anesthesia, the rats were humanely killed by bleeding. Parietal peritoneal samples were then taken from same location (away from the injection site) and changes of parietal peritoneum morphology were examined by a single pathologist. The CG severely disturbed parameters of peritoneal morphology, increasing peritoneal thickness, inflammatory activity, vascularity, and fibrosis score as compared with the Control group ( p < 0.05). No benefit was observed for any parameter in the Resting group as compared withthose parameters in the CG group ( p < 0.05). We observed a lower fibrosis score and less peritoneal thickness in the GC group as compared with the Resting group ( p < 0.05). No beneficial effects of AZT on peritoneal morphology were observed as compared with the effects of peritoneal rest or corticosteroid therapy. Treatment with cyclosporin resulted in more fibrosis, vascularity, and inflammation than was seen with corticosteroid therapy ( p < 0.05). Immunosuppressive therapies, especially those that are corticosteroid-based, may have therapeutic value in the management of EPS. Patients treated with cyclosporin may have a risk for developing EPS.
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- 2009
28. To Feed or Not to Feed? During Hemodialysis Session
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Şennur Köse, Ender Hür, Hüseyin Çelik, Gökhan Atay, Bünyamin Altundal, and Soner Duman
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intradialytic hypotension ,hemodialysis ,muscle cramps ,Medicine - Abstract
Introduction: Patients undergoing hemodialysis (HD) like to eat during HD sessions. To prevent coronavirus infection, health authorities recommended restriction of taking food and fluids. In this multicenter retrospective chart review study, we aimed to confirm the relationship between oral intake and intradialytic complications using the date before and after the restriction in a relatively large HD population. Methods: Data of a total of 190 (47% female) patients with prevalent HD during the 3 months before and 3 months after the restriction of oral intake during HD session were collected. In patients who received HD three times a week, data on blood biochemicals and clinical parameters taken routinely at the first week of each month were recorded from the dialysis session files. Differences between the means for both periods were evaluated using the χ² test for categorical variables and Student’s t-test for continuous variables; p
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- 2022
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29. SP653A NEW METHOD TO PREDICT SURVIVAL IN HEMODIALYSIS PATIENTS IMPEDANCE RATIO
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Bilal Zoka, Kemal Magden, Sennur Kose, Siren Sezer, Soner Duman, Elif Duman, Cenk Gokalp, Ender Hur, and Gürsel Yildiz
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Transplantation ,medicine.medical_specialty ,Nephrology ,business.industry ,medicine.medical_treatment ,Internal medicine ,medicine ,Cardiology ,Hemodialysis ,business ,Electrical impedance - Published
- 2017
30. SP611DOES INTERDIALYTIC WEIGHT GAIN EFFECT HEMOGLOBIN VARIABILITY
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Soner Duman, Huseyin Taskin, Neşe Büyükoğlan, Gürcan Yurtman, Ender Hur, Merve Gulsah Ulusoy, Necati Özkan, Zeki Malkoç, Cenk Gokalp, Elif Duman, Ilhan Akgungor, Ertugrul Cakır, Ozge Timur, and Selahattin Bicak
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Transplantation ,Animal science ,Nephrology ,business.industry ,medicine ,Hemoglobin ,medicine.symptom ,business ,Weight gain - Published
- 2017
31. Hypervolemia for Hypertension Pathophysiology: A Population-Based Study
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Cihan Ural, Ender Hur, Cagatay Buyukuysal, Melih Özişik, Kemal Magden, Kenan Ates, Soner Duman, Sennur Kose, Gultekin Suleymanlar, Gürsel Yildiz, Ibrahim Yildirim, Furuzan Kokturk, Zonguldak Bülent Ecevit Üniversitesi, and Ege Üniversitesi
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Adult ,Male ,medicine.medical_specialty ,Article Subject ,Adolescent ,Turkey ,Population ,Statistics as Topic ,Water-Electrolyte Imbalance ,lcsh:Medicine ,Blood Pressure ,Comorbidity ,General Biochemistry, Genetics and Molecular Biology ,chemistry.chemical_compound ,Young Adult ,Risk Factors ,Internal medicine ,Diabetes mellitus ,medicine ,Intravascular volume status ,Humans ,education ,Aged ,Aged, 80 and over ,education.field_of_study ,Creatinine ,General Immunology and Microbiology ,business.industry ,Incidence ,lcsh:R ,General Medicine ,Middle Aged ,medicine.disease ,Causality ,Blood pressure ,Endocrinology ,chemistry ,Pathophysiology of hypertension ,Hypertension ,Cardiology ,Female ,Hypervolemia ,business ,Body mass index ,Research Article - Abstract
WOS: 000340761700001, PubMed ID: 25177700, Objectives. Hypertension and hypervolemia relationship was proven among renal disease, although it is not known in normal population. Present study determines the fluid distribution defects in relation to blood pressure. Material and Methods. In a population-based survey in Turkey demographics, height, weight, blood pressure, urine analysis, and serum creatinine measurements were recorded. Bioimpedance measured with the Body Composition Monitor. Results. Total 2034 population of 71.6% male, mean age 47 +/- 12.6 (18-89) years, systolic blood pressure (SBP) 134.7 +/- 20, diastolic blood pressure 77.9 +/- 11.6 mmHg. Body mass index (BMI) was 28.5 +/- 4.5 (15.8-50.6) kg/m(2); overhydration was 0.05 +/- 1.05 L. There was a correlation between extracellular water (ECW)/height and SBP (r = 0.21, P < 0.001). Receiver operating characteristic (ROC) curve with the performance of 0.60 (P < 0.001) that showed cut-off value of ECW/height was 10.06 L/m, with the 69% sensitivity and 45% specificity for SBP: 140 mmHg values. Risk factors for high SBP were increase of ECW/Height, age, BMI and presence of diabetes. ECW/height, SBP, and fat tissue index (FTI) increased in BMI categories (low, normal, and obese) and in diabetics. SBP and FTI were lower in smokers. Conclusions. High blood pressure may be accompanied by increased extracellular volume indices. In the future volume status assessment could be of use in evaluating the effectiveness of pharmacological intervention in the treatment of hypertension.
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- 2014
32. Kolistin ve akut böbrek yetmezliği: Tek merkez deneyimi
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Enveriye Severcan, Volkan Eminoglu, Necmiye Karaca, Oznur Tavsan, Ender Hur, Adife Cetinturk, Soner Duman, murvet Sungur, Serhan Piskinpasa, and Ege Üniversitesi
- Subjects
medicine.medical_specialty ,business.industry ,Urology ,Family medicine ,University faculty ,medicine ,Colistin ,Surgery ,Intensive care medicine ,business ,State hospital ,medicine.drug ,Cerrahi - Abstract
AMAÇ: Kolistin gram negatif basillerde etkili, polipeptid yapıda bir polimiksin antibiyotiğidir. Geçmişte yan etkileri nedeniyle kullanımı azalmasına karşın son yıllarda özellikle çoklu ilaç direnci olan Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter ve Enterobacteriaceae’da etkinliği olduğundan kullanımı giderek artmaktadır. Bu çalışmada, merkezimizde kolistin kullanılan hastalar nefrotoksisite yönünden retrospektif olarak değerlendirilmiştir. GEREÇ ve YÖNTEMLER: Çalışmaya Ocak 2012– Ağustos 2013 yıllarında 2. basamak yoğun bakım ünitemizde yatarak kolistin tedavisi alan hastalar alındı. Demografik veriler; bazal, yatış sırasında günlük alınan ve taburculuk sonrası bakılan biyokimyasal tetkikler; ve kolistin başlangıç, idame ve toplamda verilen dozları değerlendirildi. BULGULAR: Yaş ortalaması 62±13 (31-86) yıl olan 17 (%63) erkek, toplam 27 hasta ortalama 63±89 gün izlenmiştir. Tüm izlem süresince hastaların 18’inde (%66,7) akut böbrek yetmezliği (ABY) gelişmiş, 17 (%63) hasta exitus olmuştur. Mortaliteler ABY grubunda 12 (%66,7), ABY olmayan grupta 5’tir (%55) (p> 0,05). Toplam kolistin dozu ve lökosit sayısı istatistiki olarak anlamlılığa ulaşmasa da ABY grubunda 3,75±2,34 g ve 12,04±5,05/mm3 olup ABY olmayan gruptaki 3,32±.1,86 g ve 7,60±3,7/ mm3 değerlerinden daha yüksektir. SONUÇ: Yoğun bakım hastalarında ABY mortaliteyi arttırmaktadır. Kolistin, dirençli enfeksiyonlarda kullanılan etkin bir tedavi ajanı olduğu halde ABY yan etkisi göz önüne alındığında bu ilacın yüksek dozlarda kullanımından mümkün olduğunca kaçınılması doğru bir yaklaşım olacaktır., OBJECTIVE: Colistin is a polymyxin antibiotic with a polypeptide structure and is effective against gram-negative bacilli. Although its use had decreased due to its side effects, it has increased again in recent years, especially for multi-drug resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter and Enterobacteriaceae. In the present study, patients that received colistin at one center were retrospectively analysed in terms of nephrotoxicity. MATERIAL and METHODS: Patients hospitalized and treated with colistin in the intensive care unit between January 2012 and August 2013 were analyzed. Demographic data; biochemical tests at baseline, daily during hospitalization and after discharge; and the initial, maintenance and total doses of colistin were evaluated. RESULTS: The mean age was 62±13 (31-86) years for the 27 patients with 17 (63%) males that were followed-up for an average duration of 63±89 days. During follow-up, 18 patients (66.7%) developed acute renal failure (ARF) and 17 (63%) of died. There were 12 (66.7%) mortalities in the ARF group and 5 (55%) in the group without ARF ( p> 0.05). The total colistin dose and leukocyte count were higher in the ARF group with 3.75±2.34 g and 12.04±5.05/mm3 than the non-ARF group at 3.32±1.86 g and 7.60±3.7/mm3 but did not reach statistical significance. CONCLUSION: ARF increases the mortality in ICU patients. Although colistin is an effective therapeutic agent used for resistant infections, we have to avoid higher doses due to its potential side effect of ARF.
- Published
- 2014
33. Inflammatory Markers: C-Reactive Protein, Erythrocyte Sedimentation Rate, and Leukocyte Count in Vitamin D Deficient Patients with and without Chronic Kidney Disease
- Author
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Furuzan Kokturk, Ender Hur, Ibrahim Yildirim, and Zonguldak Bülent Ecevit Üniversitesi
- Subjects
Vitamin ,medicine.medical_specialty ,Article Subject ,Endocrinology, Diabetes and Metabolism ,Population ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Gastroenterology ,Cachexia ,chemistry.chemical_compound ,Endocrinology ,Internal medicine ,Vitamin D and neurology ,Medicine ,Hypoalbuminemia ,Vitamin B12 ,education ,education.field_of_study ,Creatinine ,lcsh:RC648-665 ,Endocrine and Autonomic Systems ,business.industry ,medicine.disease ,chemistry ,Immunology ,business ,Kidney disease ,Research Article - Abstract
Although some studies revealed a positive relationship between vitamin D3deficiency and inflammatory markers, there have been also many studies that failed to find this relationship. The aim of this large scaled study is to determine the association between the level of plasma 25 hydroxy vitamin D3[25-(OH) D3] and inflammatory markers in the general population without chronic kidney disease (CKD) and in patients with CKD. Participants with simultaneously measured inflammatory markers and 25-(OH) D3levels were retrospectively analyzed (n=1897). The incidence of all-cause inflammation infection, hospitalization, chronic renal failure, and vitamin B12 deficiency was evaluated. The medians of serum creatinine levels in subjects without renal failure were lower in 25-(OH) D3deficient group. Patients with CKD were more likely to have vitamin D3deficiency compared with normal GFR. 25-(OH) D3levels were associated with a greater incidence of all-cause hospitalization, hypoalbuminemia, and vitamin B12 deficiency. However, there was no relationship between inflammatory markers and vitamin D3levels. In 25-(OH) D3deficient patients, inflammatory markers can be related to other inflammatory and infectious status such as malnutrition and cachexia. We believed that there must be a relationship between vitamin deficiency and inflammatory markers due to other causes than low 25-(OH) D3status.
- Published
- 2013
34. The effects of vitamin D on gentamicin-induced acute kidney injury in experimental rat model
- Author
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Zehra Narli Ozdemir, Melih Özişik, Eser Yıldırım Sözmen, Asuman Camyar, Alev Garip, Ender Hur, Murat Olukman, Sait Şen, Sibel Ilgun, Fehmi Akcicek, Sena Tuna, Soner Duman, Zonguldak Bülent Ecevit Üniversitesi, and Ege Üniversitesi
- Subjects
medicine.medical_specialty ,Pathology ,Article Subject ,Endocrinology, Diabetes and Metabolism ,Urology ,Urine ,medicine.disease_cause ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Nephrotoxicity ,chemistry.chemical_compound ,Endocrinology ,Renin–angiotensin system ,medicine ,Vitamin D and neurology ,Creatinine ,lcsh:RC648-665 ,Endocrine and Autonomic Systems ,business.industry ,Acute kidney injury ,medicine.disease ,chemistry ,Gentamicin ,business ,Oxidative stress ,medicine.drug ,Research Article - Abstract
WOS: 000320810800001, PubMed ID: 23843788, Introduction. Acute kidney injury (AKI) pathogenesis is complex. Findings of gentamicin nephrotoxicity are seen in 30% of the AKI patients. Vitamin D has proven to be effective on renin expression, inflammatory response, oxidative stress, apoptosis, and atherosclerosis. We aimed to investigate the effect of vitamin D in an experimental rat model of gentamicin-induced AKI. Methods. Thirty nonuremic Wistar albino rats were divided into 3 groups: Control group, 1 mL saline intramuscular (im) daily; Genta group, gentamicin 100 mg/kg/day (im); Genta + vitamin D, gentamicin 100 mg/kg/day (im) in addition to 1 alpha, 25 (OH)(2)D-3 0.4 mcg/kg/day subcutaneously for 8 days. Blood pressures and 24-hour urine were measured. Blood urea and creatinine levels and urine tubular injury markers were measured. Renal histology was semiquantitatively assessed. Results. Urea, creatinine and urine neutrophil gelatinase-associated lipocalin, and kidney injury molecule-1 were all increased in Genta group indicating AKI model. Systolic blood pressure decreased, but urine volume and glutathione increased in Genta + Vit D group compared to Control group. Histological scores indicating tubular injury increased in Genta and Genta + Vit D groups. Conclusions. Vitamin D does not seem to be effective on histological findings although it has some beneficial effects via RAS system and a promising effect on antioxidant system.
- Published
- 2013
35. Evaluation of association between atherogenic index of plasma and intima-media thickness of the carotid artery for subclinic atherosclerosis in patients on maintenance hemodialysis
- Author
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Huseyin Aydin, Abdulkerim Yilmaz, Gürsel Yildiz, Alptekin Duman, Gülay Çetin, Kemal Magden, Ender Hur, Ferhan Candan, Zonguldak Bülent Ecevit Üniversitesi, [Yildiz, Gursel] Ataturk State Hosp, Dept Internal Med & Nephrol, Zonguldak, Turkey -- [Hur, Ender -- Magden, Kemal] Bulent Ecevit Univ, Sch Med, Dept Nephrol, Zonguldak, Turkey -- [Duman, Alptekin] Cumhuriyet Univ, Sch Med, Dept Internal Med, Sivas, Turkey -- [Aydin, Huseyin] Cumhuriyet Univ, Sch Med, Dept Biochem, Sivas, Turkey -- [Yilmaz, Abdulkerim] Cumhuriyet Univ, Sch Med, Dept Gastroenterol, Sivas, Turkey -- [Cetin, Gulay] Sivas State Hosp, Dept Radiol, Sivas, Turkey -- [Candan, Ferhan] Cumhuriyet Univ, Sch Med, Dept Nephrol, Sivas, Turkey, and [Duman, Alptekin -- Aydin, Huseyin -- Yilmaz, Abdulkerim -- Candan, Ferhan] Cumhuriyet Univ, Sivas, Turkey -- [Yildiz, Gursel] Ataturk State Hosp, Zonguldak, Turkey -- [Hur, Ender -- Magden, Kemal] Bulent Ecevit Univ, Zonguldak, Turkey -- [Cetin, Gulay] Sivas State Hosp, Sivas, Turkey
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Adult ,Carotid Artery Diseases ,Male ,Hemodialysis patients ,medicine.medical_specialty ,hemodialysis patients ,medicine.medical_treatment ,education ,subclinic athersclerosis ,Carotid Intima-Media Thickness ,Renal Dialysis ,Risk Factors ,Internal medicine ,Humans ,Medicine ,In patient ,cardiovascular diseases ,Subclinic athersclerosis ,Renal Insufficiency, Chronic ,Risk factor ,health care economics and organizations ,business.industry ,carotid artery intima-media thickness ,Incidence (epidemiology) ,Atherogenic index of plasma ,social sciences ,Hematology ,Maintenance hemodialysis ,Atherosclerosis ,medicine.disease ,Carotid Arteries ,Endocrinology ,Intima-media thickness ,Nephrology ,Disease Progression ,Cardiology ,cardiovascular system ,Carotid artery intima-media thickness ,Female ,Hemodialysis ,business ,Lipoprotein ,Kidney disease - Abstract
50th European-Renal-Association - European-Dialysis-and-Transplant-Association Congress -- MAY 18-21, 2013 -- Istanbul, TURKEY, WOS: 000319498202399, …, European Renal Assoc (ERA), European Dialysis & Transplant Assoc (EDTA)
- Published
- 2013
36. SP399A NEW TECHNIQUE FOR ESTABLISHING DRY WEIGHT IN HEMODIALYSIS PATIENTS VIA ESTIMATION OF PULMONARY CAPILLARY WEDGE PRESSURE. A TISSUE DOPPLER IMAGING STUDY
- Author
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Ender Hur, Kemal Magden, Gürsel Yildiz, Ferhan Candan, Mansur Kayataş, and Mehmet Yilmaz
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Transplantation ,medicine.medical_specialty ,Dry weight ,Nephrology ,business.industry ,medicine.medical_treatment ,medicine ,Radiology ,Hemodialysis ,business ,Pulmonary wedge pressure ,Doppler imaging ,Surgery - Published
- 2016
37. Congenital adrenal hyperplasia: a rare cause of renal failure and a successful renal transplantation
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Fatih Kircelli, Adnan Şimşir, Cuneyt Hoscoskun, Ozkan Gungor, Ender Hur, Firat Okmen, Juan Jesus Carrero, Hamad Dheir, and Huseyin Toz
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,medicine.medical_treatment ,Population ,Steroid biosynthesis ,urologic and male genital diseases ,medicine ,Outpatient clinic ,Humans ,Congenital adrenal hyperplasia ,education ,Kidney transplantation ,education.field_of_study ,Adrenal Hyperplasia, Congenital ,business.industry ,General Medicine ,medicine.disease ,Kidney Transplantation ,Transplantation ,Nephrology ,Kidney Failure, Chronic ,Hemodialysis ,business ,Rare disease - Abstract
Congenital adrenal hyperplasia belongs to a group of autosomal recessive disorders affecting steroid biosynthesis; a rare disease with a prevalence of 1 case per 16,000 population. A 30-year-old phenotypically male patient had been diagnosed with 11-β hydroxylase deficiency at the age of 16; presenting with ambiguous genitalia, growth retardation, presence of menstrual cycles, severe hypertension, hypokalemia and renal dysfunction. He developed endstage renal disease due to hypertension and was treated with hemodialysis for 3 y. After careful evaluation, he was approved to undergo renal transplantation. The patient has now finished 6th month after transplantation and is currently under follow-up at our outpatient clinic, having no problems related to the transplant. While early treatment to prevent hypertension is mandatory in patients with congenital adrenal hyperplasia, once renal failure occurs, renal transplantation may the best choice of treatment. In this study, we describe the first report of a successful renal transplantation in an adrenal hyperplasia.
- Published
- 2012
38. Can aortic elastic parameters be used for the diagnosis of volume overload in patients with end stage renal disease
- Author
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Mehmet Ali Çetiner, Muhammet Rasit Sayin, Ender Hur, Sait Mesut Dogan, Ibrahim Akpinar, Mustafa Aydin, Turgut Karabag, and Zonguldak Bülent Ecevit Üniversitesi
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Volume overload ,Blood volume ,Blood Pressure ,Aortic elastic parameters ,End stage renal disease ,Peritoneal dialysis ,Body composition monitor ,Vascular Stiffness ,Bioimpedance spectroscopy ,Renal Dialysis ,medicine.artery ,Internal medicine ,medicine ,Humans ,Aorta ,Aged ,Heart Failure ,Blood Volume ,business.industry ,Reproducibility of Results ,General Medicine ,Middle Aged ,medicine.disease ,Elasticity ,Cross-Sectional Studies ,Nephrology ,Echocardiography ,Heart failure ,Case-Control Studies ,Dielectric Spectroscopy ,Cardiology ,Body Composition ,Kidney Failure, Chronic ,Aortic stiffness ,Female ,Hemodialysis ,Cardiology and Cardiovascular Medicine ,business ,Peritoneal Dialysis - Abstract
Background: We aimed here to investigate hydration status by echocardiography in end stage renal disease (ESRD) patients. Methods: 25 ESRD patients [15 males; mean age: 54.0 ± 16.6 years; 13 hemodialysis; 12 peritoneal dialysis] were considered eligible for this study. We also examined 29 healthy volunteers as a control group (17 males; mean age: 46.5 ± 12.8 years). Body composition analysis using the bioimpedance spectroscopy technique was performed for volume overload diagnosis. The ratio of extracellular water (ECW) to height was used as volume indices. The aortic elastic parameters were calculated by echocardiography. A correlation analyses was performed between the ratio of ECW to height indicating the volume overload and the aortic elastic parameters e.g. Aortic strain (AS), Aortic distensibility (AD) and Aortic stiffness index (ASI). Results: The ratio of ECW to height that indicates volume overload in ESRD patients was considerably higher than that in the control group (10.25 ± 1.98 L/m vs 8.66 ± 1.22 L/m, p=0.001). There was a negative correlation between the ratio of ECW to height and AS and AD and a positive correlation between the ratio of ECW to height and ASI. Conclusion: Given the importance of the diagnosis and follow up of volume overload, the results show that aortic elasticity measurements, being easy to perform and replicate, can be used for this purpose. © 2012 S. Karger AG, Basel.
- Published
- 2012
39. Infection Inflammation and Vitamin D
- Author
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Yildirim I, Magden K, and Ender Hur
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Vitamin ,education.field_of_study ,business.industry ,Vitamin D-binding protein ,Population ,Pharmaceutical Science ,Inflammation ,medicine.disease ,vitamin D deficiency ,chemistry.chemical_compound ,Immune system ,Complementary and alternative medicine ,chemistry ,Rheumatoid arthritis ,Immunology ,medicine ,Vitamin D and neurology ,Pharmacology (medical) ,medicine.symptom ,education ,business - Abstract
Vitamin D is essential for the organism and it interacts with a lot of systems in mammalians. Vitamin D deficiency is common in the world. Many studies have shown that chronic vitamin D deficiency may have serious adverse consequences such as increased risk of hypertension, multiple sclerosis, rheumatoid arthritis, infections and malignancy, autoimmune diseases. New ones have been added on these adverse consequences nowadays. Vitamin D has got both stimulatory and antiproliferative effects on the immune system. This paradoxical effects of 1, 25-(OH)2D3 leads to discussions about the relationship between the immune systems and vitamin D. Inflammatory markers can be increased with other reasons in patients with vitamin D deficiency. Vitamin D deficiency may occur due to insufficient intake, hepatic disease, renal disease, loss of vitamin D binding protein etc. Many confounding factors will affect this relationship in both cases. Despite large-scaled studies found a positive relationship between vitamin D deficiency and some markers of inflammation but on the contrary many studies cannot find this relationship. The aim of this brief review is to discuss whether plasma 25 hydroxy vitamin D [25-(OH) D] level is associated with inflammatory markers in general population and in patients with chronic kidney disease. For this purpose, the old and new data related to the immune systems and vitamin D will be examined.
- Published
- 2012
40. The effects of mycophenolate mofetil on encapsulated peritoneal sclerosis model in rats
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Selahattin Bicak, Soner Duman, Ozge Timur, Ender Hur, Banu Sarsik, Fehmi Akcicek, and Devrim Bozkurt
- Subjects
Male ,Vascular Endothelial Growth Factor A ,medicine.medical_treatment ,Gene Expression ,Inflammation ,Pharmacology ,Mycophenolate ,Peritoneal dialysis ,Transforming Growth Factor beta1 ,Vascularity ,Peritoneal Sclerosis ,medicine ,Animals ,Rats, Wistar ,Saline ,Chemokine CCL2 ,Neovascularization, Pathologic ,business.industry ,Anti-Inflammatory Agents, Non-Steroidal ,Peritoneal Fibrosis ,General Medicine ,Mycophenolic Acid ,Rats ,Disease Models, Animal ,Cytokine ,Nephrology ,medicine.symptom ,Peritoneum ,Complication ,business ,Peritoneal Dialysis - Abstract
INTRODUCTION Encapsulated peritoneal sclerosis (EPS) is a devastating complication of peritoneal dialysis. We aimed to investigate the effects of mycophenolate mofetil (MMF) treatment in experimental EPS in rats. METHODS 40 nonuremic Wistar albino rats were divided equally into 4 groups: control rats received 2 ml isotonic saline intraperitoneally daily for 3 weeks without any other treatment. The chlorhexidine gluconate group received intraperitoneally 2 ml/200 g injection of chlorhexidine gluconate and ethanol dissolved in saline for 3 weeks. The resting group received chlorhexidine gluconate (0 - 3rd week) + peritoneal resting (4th - 6th week). The MMF group received chlorhexidine gluconate (0 - 3rd week) + 125 mg/l MMF in drinking water (4th - 6th week). Dialysate cytokine levels, leukocyte count, peritoneal thickness, inflammation and fibroblast activities were evaluated. RESULTS Although the MMF and resting groups showed beneficial effects on ultrafiltration and D1/D0 glucose compared to the chlorhexidine gluconate group, only MMF treatment improved dialysate TGFβ1, VEGF and MCP-1 levels compared to the resting group. Inflammatory activity and vascularity observed in a tissue biopsy, including capillaries number per mm2 of submesothelial area, decreased in the treatment group. CONCLUSIONS MMF treatment has beneficial effects on EPS via inhibiting inflammation and neovascularisation by reducing dialysate VEGF overexpression.
- Published
- 2011
41. Bioimpedance spectroscopy for the detection of hypervolemia in peritoneal dialysis patients
- Author
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Ender, Hur, Ozkan, Gungor, Oktay, Musayev, Mehmet, Usta, Huseyin, Toz, Gulay, Asci, Mehmet, Ozkahya, Soner, Duman, and Ercan, Ok
- Subjects
Adult ,Aged, 80 and over ,Male ,Water-Electrolyte Imbalance ,Middle Aged ,Young Adult ,Body Water ,Peritoneal Dialysis, Continuous Ambulatory ,Echocardiography ,Dielectric Spectroscopy ,Humans ,Female ,Hypertrophy, Left Ventricular ,Aged - Abstract
A practical, inexpensive, and reliable method is needed for the assessment of volume status in peritoneal dialysis (PD) patients. In the present study, we investigated the efficiency of bioimpedance spectroscopy (BIS) for detection of hypervolemia. The study enrolled 79 prevalent PD patients (mean age: 47 +/- 14 years; PD duration: 30 +/- 17 months; 55% men; 19% with diabetes) from a single center. Echocardiography and body composition analysis using the BIS technique [50 frequencies (Body Composition Monitor: Fresenius Medical Care, Bad Homburg, Germany)] were performed. Overhydration (OH) and extracellular water (ECW) in liters and OH/ECW ratio were used as volume indices. The mean left ventricular (LV) mass index was 117 +/- 37 g/m2, and 46% of patients had LV hypertrophy (LVH). Mean OH and OH/ECW ratio were 1.3 +/- 1.7 L and 7.6% +/- 9.3% respectively The OH/ ECW ratio correlated with LV mass index (r = 0.237, p0.036) and with left atrium index (r = 0.354, p0.001). Compared with patients not having LVH, patients with LVH had higher OH values (1.79 +/- 1.82 L vs 0.93 +/- 1.62 L, p = 0.003). In linear regression analysis, the OH/ECW ratio was an independent risk factor for LVH (t = 2.558, p = 0.01). In PD patients, BIS is a reliable method for evaluating volume status. The OH/ECW measured by BIS is a major determinant of LV mass. Control of hypervolemia and blood pressure is associated with better cardiac condition.
- Published
- 2011
42. The effect of immunosuppressive treatment on arterial stiffness and matrix Gla protein levels in renal transplant recipients
- Author
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Özlem Güngör, Juan Jesus Carrero, Fatih Kircelli, Meltem Sezis Demirci, Gulay Asci, Huseyin Toz, and Ender Hur
- Subjects
Nephrology ,Adult ,Male ,Mean arterial pressure ,medicine.medical_specialty ,Calcification inhibitor ,Adolescent ,Calcineurin Inhibitors ,Urology ,Blood Pressure ,Enzyme-Linked Immunosorbent Assay ,Electrocardiography ,Predictive Value of Tests ,Internal medicine ,Matrix gla protein ,medicine ,Humans ,Pulse wave velocity ,Aged ,Analysis of Variance ,Extracellular Matrix Proteins ,biology ,business.industry ,TOR Serine-Threonine Kinases ,Calcium-Binding Proteins ,Age Factors ,General Medicine ,Middle Aged ,medicine.disease ,Kidney Transplantation ,Surgery ,Transplantation ,Femoral Artery ,Proteinuria ,Blood pressure ,Carotid Arteries ,Cholesterol ,Cross-Sectional Studies ,Treatment Outcome ,Creatinine ,Arterial stiffness ,biology.protein ,Female ,Vascular Resistance ,business ,Blood Flow Velocity ,Immunosuppressive Agents - Abstract
Introduction Arterial stiffness is a risk marker for cardiovascular events. In this study we aimed to compare the effect on calcineurin inhibitors (CNI) and mammalian Target of Rapamycine inhibitors (mTORi) on arterial stiffness in renal transplant patients. Patients and methods 81 renal transplant patients under CNI-based or mTORi-based protocol for at least 6 months were included in the study. Arterial stiffness was measured by using the SphygmoCor device (AtCor Medical, Sydney, Australia). Vitamin K-dependent, calcification inhibitor matrix Gla protein (MGP) concentrations were quantified by ELISA methods (Biomedica, Vienna, Austria). Results 34 patients were on mTORi-based and 47 on CNI-based immunosuppression. Mean age was 37.9 ± 10.8 (18 - 71) years and 45% were female. Age, gender, graft functions and follow-up period of the groups were similar. Augmentation index was 15.2 ± 12.6% in CNI and 18.8 ± 14.0% in mTORi groups (p > 0.05). There was no difference regarding carotid-femoral pulse wave velocity between groups. Arterial stiffness was positively correlated with age, total cholesterol, LDL cholesterol, mean arterial pressure (MAP) and proteinuria. MGP levels were higher in the mTORi group but were not predictors for carotid-femoral pulse wave velocity. Conclusion Rather than specific immunosuppressive drug effects, conventional risk factors, blood pressure and proteinuria are the most important predictors for arterial stiffness in renal transplant patients.
- Published
- 2011
43. Octreotide lessens peritoneal injury in experimental encapsulated peritoneal sclerosis model
- Author
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Muhittin Ertilav, Ender Hur, Devrim Bozkurt, Sipahi, Savaş, Ozge Timur, Banu Sarsik, Fehmi Akcicek, Duman, Soner, Ertilav, M, Hur, E, Bozkurt, D, Sipahi, S, Timur, O, Sarsik, B, Akcicek, F, Duman, S, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Sipahi, Savaş, and Duman, Soner
- Subjects
Male ,Vascular Endothelial Growth Factor A ,Neovascularization, Pathologic ,Chlorhexidine ,Anti-Inflammatory Agents ,Angiogenesis Inhibitors ,Peritoneal Fibrosis ,Urology & Nephrology ,Octreotide ,Fibrosis ,Permeability ,Rats ,Transforming Growth Factor beta1 ,Disease Models, Animal ,Dialysis Solutions ,Animals ,Peritoneum ,Rats, Wistar ,Peritoneal Dialysis ,Chemokine CCL2 - Abstract
Encapsulated peritoneal sclerosis is characterized by neoangiogenesis and fibrosis. Octreotide, a somatostatin analogue is a well-known antifibrotic, antiproliferative and anti-angiogenic agent. The aim of the study is to evaluate the effects of octreotide in encapsulated peritoneal sclerosis-induced neoangiogenesis and fibrosis and compare the results with resting.Non-uraemic Wistar-Albino male rats (n = 35) were divided into four groups. Group I, control rats, received 2 mL isotonic saline i.p. daily for 3 weeks. Group II, received daily i.p. 2 mL/200 g injection of chlorhexidine gluconate (0.1%) and ethanol (%15) dissolved in saline for 3 weeks. Group III, chlorhexidine gluconate for 3 weeks plus an additional 3 weeks without any treatment (rest), to a total of 6 weeks. Group IV, chlorhexidine gluconate for 3 weeks plus an additional 3 weeks octreotide, 50 mcg/kg bodyweight s.c., for a total of 6 weeks.Octreotide significantly reversed ultrafiltration capacity of peritoneum with decreasing inflammation, neoangiogenesis and fibrosis compared to the resting group. Octreotide also caused inhibition of dialysate transforming growth factor-β1, vascular endothelial growth factor and monocyte chemotactic protein-1 activity and improved mesothelial cell cytokeratin expression. Peritoneal resting has no beneficial effects on peritoneum.In conclusion, octreotide may have a therapeutic value in peritoneal dialysis patients who suffer from encapsulated peritoneal sclerosis.
- Published
- 2011
44. Insight to Case Reports
- Author
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Ender Hur
- Subjects
medicine.medical_specialty ,Medical education ,business.industry ,Statement (logic) ,Clinical question ,Alternative medicine ,medicine ,Bioinformatics ,business ,Academic medicine ,Treatment efficacy - Abstract
Clinical question or problem Summary statement of why this case is noteworthy. What is the Educational Message? Can be done away with altogether if the Abstract is satisfactory
- Published
- 2011
45. Body composition monitor measurement technique for the detection of volume status in peritoneal dialysis patients: the effect of abdominal fullness
- Author
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Ali Tamer, Soner Duman, Saadet Demirtaş, Devrim Bozkurt, Ender Hur, Ibrahim Kocayigit, Savas Sipahi, Huseyin Gunduz, Sipahi, S, Hur, E, Demirtas, S, Kocayigit, I, Bozkurt, D, Tamer, A, Gunduz, H, Duman, S, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Sipahi, Savaş, Kocayiğit, İbrahim, Tamer, Ali, Gündüz, Hüseyin, and Duman, Soner
- Subjects
Male ,medicine.medical_specialty ,Urology ,medicine.medical_treatment ,Water-Electrolyte Imbalance ,Peritoneal equilibration test ,Left ventricular hypertrophy ,Peritoneal dialysis ,Body Water ,Extracellular fluid ,medicine ,Intravascular volume status ,Electric Impedance ,Humans ,Renal Insufficiency ,Ejection fraction ,business.industry ,Stroke Volume ,Middle Aged ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Nephrology ,Echocardiography ,Dielectric Spectroscopy ,Body Composition ,Abdomen ,Female ,Hypertrophy, Left Ventricular ,business ,Nuclear medicine ,Hypervolemia ,Peritoneal Dialysis - Abstract
Bioimpedance spectroscopy (BIS) is used to assess volume status in peritoneal dialysis (PD) patients. However, it is proposed that it may be troubling in patients with abnormal fluid distribution and body geometry. It is not clear whether having an empty abdomen or not interferes with the BIS results and its relation with echocardiographic findings in PD patients.Twenty-five prevalent PD patients were enrolled. Echocardiography and body composition analysis using BIS technique (50 frequencies, the Body Composition Monitor, BCM) were performed. Overhydration (OH), extracellular water (ECW) in liters and OH/ECW ratio were used as volume status indices. Differences in volume and echocardiographic findings, in patients with empty and with full abdomen, and their correlations with echocardiographic parameters were investigated.Mean age and PD duration were 61 ± 2.5 years and 42 ± 33 months, respectively. Sixty-four percent were male and 24% were diabetic. Mean left ventricular mass index (LVMi) was 131 ± 43 g/m (,) (2) mean left atrium diameter (LA) was 4.1 ± 0.1 cm, mean left ventricular ejection fraction (EF) was 64 ± 10%. Mean OH in patients with full abdomen were 1.67 ± 1.51 L and 1.68 ± 1.48 L, depending on the inclusion or exclusion of the dialysate volume, respectively. In patients with an empty abdomen, mean OHs were 2.12 ± 1.76 L and 1.91 ± 1.56 L, depending on the inclusion or exclusion of the dialysate volume. BIS measurements with an empty, but not with a full abdomen, was related to the echocardiographic parameters.BIS is a reliable method to evaluate volume status in PD patients. BIS performed after peritoneal equilibration test with an empty abdomen, better reflects overhydration and is related to echocardiographic parameters.
- Published
- 2011
46. Serum Paraoxonase 1 Activity Predicts Arterial Stiffness in Renal Transplant Recipients
- Author
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Erhan Tatar, Ozkan Gungor, Huseyin Toz, Ali Riza Sisman, Gulay Asci, Meltem Sezis Demirci, Ercan Ok, Pinar Tuncel, Fatih Kircelli, Ender Hur, and Ege Üniversitesi
- Subjects
Adult ,medicine.medical_specialty ,Mean arterial pressure ,Renal function ,Vascular Stiffness ,Internal medicine ,Internal Medicine ,medicine ,Renal Transplantation ,Humans ,Pulse wave velocity ,Proteinuria ,biology ,business.industry ,Aryldialkylphosphatase ,Biochemistry (medical) ,Paraoxonase ,Arteries ,Middle Aged ,medicine.disease ,Arterial stiffness ,Kidney Transplantation ,Transplantation ,Blood pressure ,Endocrinology ,Cardiology ,biology.protein ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
WOS: 000297673000008, PubMed ID: 21737961, Aim: Paraoxanase 1 (PON 1) has been shown to protect against atherosclerosis by modifying lipoproteins. Its activity decreases in dialysis patients but is restored after transplantation. Whether it affects arterial stiffness is unclear. In this study we aimed to investigate the effects of PON 1 on arterial stiffness in renal transplant patients. Methods: Seventy renal transplant recipients were enrolled. Arterial stiffness was measured using a Syphmocor device. PON-1 activity was assessed from the rate of enzymatic hydrolysis of paraoxon to p-nitrophenol. Results: Mean age was 39.0 +/- 9.6 years and 5.7% of the patients were diabetic. Post-transplant follow-up time was 46.7 +/- 37.9 months. Eighty-five percent received anti-hypertensive and 12.9% anti-hyperlipidemic medication. Mean PON1 activity was 75.9 +/- 52.4 U/L. PON1 activity was negatively correlated with systolic and diastolic blood pressure, mean arterial pressure, LDL-cholesterol and carotid-femoral pulse wave velocity (cf-PWV). Mean c-f PWV was 8.10 +/- 1.39 m/s. Cf-PWV was positively correlated with age, systolic and diastolic blood pressure, mean arterial pressure, proteinuria and negatively correlated with PON1, PON1/HDL ratio and creatinine clearance. In linear regression analysis, PON1 was a predictor of cf-PWV in a model that included age, gender, diabetes, mean arterial pressure, urine protein level, creatinine clearance and PON 1. Conclusions: Reduced PON1 activity is significantly associated with increased arterial stiffness. The results of this study show the possible role of PON1 for arterial stiffening in renal transplant recipients.
- Published
- 2011
47. Volume status effected by gravity and body fluid shifts: new protocol for bioimpedance measurements
- Author
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Huseyin Taskin, Soner Duman, Sennur Kose, Selahattin Bicak, and Ender Hur
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Body fluid ,medicine.medical_specialty ,Nephrology ,business.industry ,Body cells ,medicine ,Intravascular volume status ,General Medicine ,Critical Care and Intensive Care Medicine ,business ,Surgery ,Biomedical engineering - Abstract
The analysis of body composition gained much more interest with the use of non-invasive practical method of bioimpedance. This technique uses electrical properties of materials like body cells. Cel...
- Published
- 2014
48. Progression of graft fibrosis under mammalian target of rapamycin inhibitor-based regimen
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Mumtaz, Yilmaz, Ahmet, Nart, Sait, Sen, Funda, Tasli, Adam, Uslu, Ender, Hur, Mehmet, Ozkahya, Cuneyt, Hoscoskun, and Huseyin, Toz
- Subjects
Adult ,Chi-Square Distribution ,Time Factors ,Turkey ,Biopsy ,TOR Serine-Threonine Kinases ,Graft Survival ,Delayed Graft Function ,Middle Aged ,Kidney ,Fibrosis ,Kidney Transplantation ,Risk Assessment ,Young Adult ,Logistic Models ,Treatment Outcome ,Risk Factors ,Disease Progression ,Humans ,Transplantation, Homologous ,Drug Therapy, Combination ,Kidney Diseases ,Atrophy ,Immunosuppressive Agents ,Retrospective Studies - Abstract
Nephrotoxic potential of mammalian target of rapamycin inhibitors (mTORi) is different from calcineurin inhibitors (CNI). The aim of this study is to investigate the interstitial fibrosis (ci) and tubular atrophy (ct) progression from the baseline to first year under a mTORi-based, CNI-free regimen.Thirty-five kidney transplant recipients who had to have adequate baseline and first year protocol biopsy were enrolled. Exclusion criteria were: the replacement of CNI at any time; acute deterioration in allograft functions; and serum creatinine level above 3 mg/dL at 12 months. Banff criteria were used for histopathological classification. Progression was defined as delta ci + ct ≥ 2 (difference between 12th month and baseline).Mean age of patients and donors were 34 ± 11 and 49 ± 10 years. Twelve patients had delayed graft function (DGF). The maintenance regimen consisted of sirolimus (n = 24) and everolimus (n = 11) with mycophenolate mofetil and steroids. Incidence of acute rejection was 25.7%. At baseline, the incidence of nil and mild fibrosis were 80% and 20%, respectively. At 12 months, 17.1% of patients had moderate, 40% had mild and 42.9% had nil fibrosis. Histological progression from baseline to first year was present in 34% of patients. In multivariate analysis the presence of DGF (P = 0.018) and deceased donor type (P = 0.011) were the most important predictors for fibrosis progression.Progression of graft fibrosis may be seen in one-third of patients under a mTORi-based regimen particularly manifested in deceased donor recipients with subsequent DGF.
- Published
- 2010
49. Endogenous Testosterone and Mortality in Male Hemodialysis Patients: Is It the Result of Aging?
- Author
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Ender Hur, Fatih Kircelli, Ozkan Gungor, Erhan Tatar, Ercan Ok, Mehmet Sukru Sever, Juan Jesus Carrero, Huseyin Toz, Turgay Arinsoy, Gulay Asci, and Ege Üniversitesi
- Subjects
Male ,Aging ,Time Factors ,Turkey ,Epidemiology ,Cross-sectional study ,medicine.medical_treatment ,Physiology ,Kaplan-Meier Estimate ,Critical Care and Intensive Care Medicine ,Risk Factors ,Testosterone ,education.field_of_study ,Hazard ratio ,Age Factors ,Middle Aged ,ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS ,Treatment Outcome ,Cardiovascular Diseases ,Nephrology ,Kidney Diseases ,Hemodialysis ,InformationSystems_MISCELLANEOUS ,Risk assessment ,Adult ,medicine.medical_specialty ,Population ,Enzyme-Linked Immunosorbent Assay ,Risk Assessment ,Renal Dialysis ,Internal medicine ,medicine ,Humans ,education ,Aged ,Proportional Hazards Models ,Transplantation ,Proportional hazards model ,business.industry ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,Testosterone (patch) ,Original Articles ,Confidence interval ,Cross-Sectional Studies ,Logistic Models ,Endocrinology ,ComputingMethodologies_PATTERNRECOGNITION ,Linear Models ,business ,Biomarkers - Abstract
WOS: 000284018500017, PubMed ID: 20651153, Background and objectives: Low serum testosterone levels in hemodialysis (HD) patients have recently been associated with cardiovascular risk factors and increased mortality. To confirm this observation, we investigated the predictive role of serum total testosterone levels on mortality in a large group of male HD patients from Turkey. Design, settings, participants, & measurements: A total of 420 prevalent male HD patients were sampled in March 2005 and followed up for all-cause mortality. Serum total testosterone levels were measured by ELISA at baseline and studied in relation to mortality and cardiovascular risk profile. Results: Mean testosterone level was 8.69 +/- 4.10 (0.17 to 27.40) nmol/L. A large proportion of patients (66%) had testosterone deficiency (10.1 nmol/L; 64 versus 81%; P = 0.004). A 1-nmol/L increase in serum testosterone level was associated with a 7% decrease in overall mortality (hazard ratio 0.93; 95% confidence interval 0.89 to 0.98; P = 0.01); however, this association was dependent on age and other risk factors in adjusted Cox regression analyses. Conclusions: Testosterone deficiency is common in male HD patients. Although testosterone levels, per se, predicted mortality in this population, this association was largely dependent on age. Clin J Am Soc Nephrol 5: 2018-2023, 2010. doi: 10.2215/CJN.03600410, Loo and Hans Osterman's Foundation; Swedish Kidney Association; Karolinska Institute's Centre for Gender MedicineKarolinska Institutet; Fresenius Medical Care, Istanbul, Turkey, J.J.C. obtained support from the Loo and Hans Osterman's Foundation, the Swedish Kidney Association, and the Karolinska Institute's Centre for Gender Medicine.; We thank all staff of the participating hemodialysis centers for their help and support.; This study was supported by Fresenius Medical Care, Istanbul, Turkey, with an unrestricted grant. EO., T.A., and M.S.S. are members of the scientific advisory board of Fresenius Medical Care, Turkey.
- Published
- 2010
50. Can N-acetylcysteine preserve peritoneal function and morphology in encapsulating peritoneal sclerosis?
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Soner Duman, Sait Şen, Ozlem Purclutepe, Ender Hur, Hasim Nar, Devrim Bozkurt, Burcu Ulkuden, and Murat Sezak
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medicine.medical_specialty ,medicine.medical_treatment ,Peritoneal equilibration test ,Peritoneal Diseases ,Dialysis tubing ,Peritoneal dialysis ,Peritoneum ,Fibrosis ,Internal medicine ,medicine ,Animals ,Rats, Wistar ,Saline ,Peritoneal Fibrosis ,Sclerosis ,business.industry ,Endothelial Cells ,General Medicine ,Free Radical Scavengers ,medicine.disease ,Angiotensin II ,Acetylcysteine ,Rats ,Disease Models, Animal ,Oxidative Stress ,medicine.anatomical_structure ,Endocrinology ,Treatment Outcome ,Nephrology ,Female ,business ,Peritoneal Dialysis ,Injections, Intraperitoneal - Abstract
Long-term use of the peritoneum as a dialysis membrane results in progressive irreversible dysfunction, described as peritoneal fibrosis. Oxidative stress during peritoneal dialysis has been established in many studies. Generation of reactive oxygen species (ROS) by conventional peritoneal dialysis solutions, regardless of whether produced by high glucose, angiotensin II, or glucose degradation products may be responsible for progressive membrane dysfunction. The well-known antioxidant molecule N-acetylcysteine (NAC) is capable of direct scavenging of ROS. The aim of the present study was to investigate the effect of NAC therapy on both progression and regression of encapsulating peritoneal sclerosis (EPS). We divided 49 nonuremic Wistar albino rats into four groups: Control group—2 mL isotonic saline intraperitoneally (IP) daily for 3 weeks; CG group—2 mL/200 g 0.1% chlorhexidine gluconate (CG) and 15% ethanol dissolved in saline injected IP daily for a total of 3 weeks; Resting group—CG (weeks 1 – 3), plus peritoneal resting (weeks 4 – 6); NAC-R group—CG (weeks 1 – 3), plus 2 g/L NAC (weeks 4 – 6). At the end of the experiment, all rats underwent a 1-hour peritoneal equilibration test with 25 mL 3.86% PD solution. Dialysate-to-plasma ratio (D/P) urea, dialysate white blood cell count (per cubic milliliter), ultrafiltration (UF) volume, and morphology changes of parietal peritoneum were examined. The CG group progressed to encapsulating peritoneal sclerosis, characterized by loss of UF, increased peritoneal thickness, inflammation, and ultimately, development of fibrosis. Resting produced advantages only in dialysate cell count; with regard to vascularity and dialysate cell count, NAC was more effective than was peritoneal rest. Interestingly, we observed no beneficial effects of NAC on fibrosis. That finding may be a result of our experimental severe peritoneal injury model. However, decreased inflammation and vascularity with NAC therapy were promising results in regard to membrane protection.
- Published
- 2009
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