1. Serum mir-142-3p release in children with viral encephalitis and its relationship with nerve injury and inflammatory response.
- Author
-
Liu Y, Wang Z, Liu X, Yang Q, Tian Z, and Liu J
- Subjects
- Humans, Male, Female, Child, Child, Preschool, Case-Control Studies, Prognosis, Biomarkers blood, Interleukin-6 blood, Interleukin-6 genetics, Interferon-gamma blood, Interferon-gamma genetics, Interleukin-18 blood, Interleukin-18 genetics, Cytokines blood, Cytokines genetics, Severity of Illness Index, Infant, MicroRNAs blood, MicroRNAs genetics, Encephalitis, Viral blood, Encephalitis, Viral virology, Encephalitis, Viral genetics
- Abstract
Background: Viral encephalitis (VE) is a common infectious disease of the central nervous system in children. Children with severe disease may have progressive neurological damage and even lead to death., Aims: To assess the serum miR-142-3p levels in children with VE and the correlation between miR-142-3p and the severity and prognosis of VE. Besides, its relationship with nerve injury and inflammatory response was assessed., Methods: Children with VE were regarded as a case group and healthy children served as control. The content of serum miR-142-3p was determined using real-time quantitative PCR. The risk factors associated with severity and prognosis of cases were evaluated using logistic analysis. The discrepancy in miR-142-3p levels, nerve injury-related indicators, and inflammatory cytokines were contrasted among groups. The ROC curve was conducted to assess the diagnostic performance of serum miR-142-3p in predicting prognosis of children with VE., Results: The altered expression of miR-142-3p in serum of children with VE was enhanced in contrast to healthy control. Serum nerve injury indicators MBP, β-EP, and NSE levels and serum inflammatory cytokines IL-6, IL-18, and IFN-γ were high in children with VE in contrast to healthy control, and had positive relevance with serum miR-142-3p. Besides, serum miR-142-3p was a risk factor associated with the severity and prognosis of children with VE. Serum miR-142-3p had diagnostic performance in predicting the prognosis of children with VE., Conclusion: Serum miR-142-3p content is high in children with VE and maybe a diagnosis marker for predicting prognosis. The specific miR-142-3p expression may be directly related to the severity of nerve injury and inflammatory response for VE., (© 2024. The Author(s) under exclusive licence to The Journal of NeuroVirology, Inc.)
- Published
- 2024
- Full Text
- View/download PDF