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2. WSES/GAIS/SIS-E/WSIS/AAST global clinical pathways for patients with intra-abdominal infections.

Author

Sartelli, Massimo, Coccolini, Federico, Kluger, Yoram, Agastra, Ervis, Abu-Zidan, Fikri, Abbas, Ashraf, Ansaloni, Luca, Adesunkanmi, Abdulrashid, Atanasov, Boyko, Augustin, Goran, Bala, Miklosh, Baraket, Oussama, Baral, Suman, Biffl, Walter, Boermeester, Marja, Ceresoli, Marco, Cerutti, Elisabetta, Chiara, Osvaldo, Cicuttin, Enrico, Chiarugi, Massimo, Coimbra, Raul, Colak, Elif, Corsi, Daniela, Cortese, Francesco, Cui, Yunfeng, Damaskos, Dimitris, De Angelis, Nicola, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, de Jonge, Stijn, Dhingra, Sameer, Di Bella, Stefano, Di Marzo, Francesco, Di Saverio, Salomone, Dogjani, Agron, Duane, Therese, Enani, Mushira, Fugazzola, Paola, Gachabayov, Mahir, Ghnnam, Wagih, Gkiokas, George, Gomes, Carlos, Griffiths, Ewen, Hardcastle, Timothy, Hecker, Andreas, Herzog, Torsten, Kabir, Syed, Karamarkovic, Aleksandar, Khokha, Vladimir, Kim, Peter, Kim, Jae, Kirkpatrick, Andrew, Kong, Victor, Koshy, Renol, Kryvoruchko, Igor, Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao, Labricciosa, Francesco, Lee, Yeong, Leppäniemi, Ari, Litvin, Andrey, Luppi, Davide, Machain, Gustavo, Maier, Ronald, Marinis, Athanasios, Marmorale, Cristina, Marwah, Sanjay, Mesina, Cristian, Moore, Ernest, Moore, Frederick, Negoi, Ionut, Olaoye, Iyiade, Ordoñez, Carlos, Ouadii, Mouaqit, Peitzman, Andrew, Perrone, Gennaro, Pikoulis, Manos, Pintar, Tadeja, Pipitone, Giuseppe, Podda, Mauro, Raşa, Kemal, Ribeiro, Julival, Rodrigues, Gabriel, Rubio-Perez, Ines, Sall, Ibrahima, Sato, Norio, Sawyer, Robert, Segovia Lohse, Helmut, Sganga, Gabriele, Shelat, Vishal, Stephens, Ian, Sugrue, Michael, Tarasconi, Antonio, Tochie, Joel, Tolonen, Matti, Tomadze, Gia, and Ulrych, Jan

Subjects
Intra-abdominal infections, Peritonitis, Sepsis, Anti-Bacterial Agents, Anti-Infective Agents, Critical Pathways, Humans, Intraabdominal Infections, Treatment Outcome
Abstract

Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported as major contributors to non-trauma deaths in hospitals worldwide. The cornerstones of effective treatment of IAIs include early recognition, adequate source control, appropriate antimicrobial therapy, and prompt physiologic stabilization using a critical care environment, combined with an optimal surgical approach. Together, the World Society of Emergency Surgery (WSES), the Global Alliance for Infections in Surgery (GAIS), the Surgical Infection Society-Europe (SIS-E), the World Surgical Infection Society (WSIS), and the American Association for the Surgery of Trauma (AAST) have jointly completed an international multi-society document in order to facilitate clinical management of patients with IAIs worldwide building evidence-based clinical pathways for the most common IAIs. An extensive non-systematic review was conducted using the PubMed and MEDLINE databases, limited to the English language. The resulting information was shared by an international task force from 46 countries with different clinical backgrounds. The aim of the document is to promote global standards of care in IAIs providing guidance to clinicians by describing reasonable approaches to the management of IAIs.

Published
2021

3. The Saudi Critical Care Society practice guidelines on the management of COVID-19 in the ICU: Therapy section

Author

Alhazzani, Waleed, Alshahrani, Mohammed, Alshamsi, Fayez, Aljuhani, Ohoud, Eljaaly, Khalid, Hashim, Samaher, Alqahtani, Rakan, Alsaleh, Doaa, Al Duhailib, Zainab, Algethamy, Haifa, Al-Musawi, Tariq, Alshammari, Thamir, Alqarni, Abdullah, Khoujah, Danya, Tashkandi, Wail, Dahhan, Talal, Almutairi, Najla, Alserehi, Haleema A., Al-Yahya, Maytha, Al-Judaibi, Bandar, Arabi, Yaseen M., Abualenain, Jameel, Alotaibi, Jawaher M., Al bshabshe, Ali, Alharbi, Reham, Al-Hameed, Fahad, Elhazmi, Alyaa, Almaghrabi, Reem S., Almaghlouth, Fatma, Abedalthagafi, Malak, Al Khathlan, Noor, Al-Suwaidan, Faisal A., Bunyan, Reem F., Baw, Bandar, Alghamdi, Ghassan, Al Hazmi, Manal, Mandourah, Yasser, Assiri, Abdullah, Enani, Mushira, Alawi, Maha, Aljindan, Reem, Aljabbary, Ahmed, Alrbiaan, Abdullah, Algurashi, Fahd, Alsaawi, Abdulmohsen, Alenazi, Thamer H., Alsultan, Mohammed A., Alqahtani, Saleh A., Memish, Ziad, Al-Tawfiq, Jaffar A., and Al-jedai, Ahmed

Published
2022
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8. Longevity of Middle East Respiratory Syndrome Coronavirus Antibody Responses in Humans, Saudi Arabia

Author

Alshukairi, Abeer N., Zhao, Jincun, Mozaini, Maha A. Al-, Wang, Yanqun, Dada, Ashraf, Baharoon, Salim A., Alfaraj, Sara, Ahmed, Waleed A., Enani, Mushira A., Elzein, Fatehi E., Eltayeb, Nazik, Layqah, Laila, Saed, Aiman El-, Bahaudden, Husam A., Haseeb, Abdul, Kafrawy, Sherif A. El-, Hassan, Ahmed M., Siddiq, Najlaa A., Alsharif, Ibtihaj, Qushmaq, Isamel, Azhar, Esam I., Perlman, Stanley, and Memish, Ziad A.

Subjects
Immune response -- Health aspects, Viral antibodies -- Health aspects, Antibodies -- Health aspects, Health
Abstract

Three novel human coronaviruses have caused different worldwide outbreaks that had variable disease severity and geographic distribution: severe acute respiratory syndrome coronavirus (SARS-CoV) during 2003; Middle East respiratory syndrome (MERS) [...]

Published
2021
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11. A pandemic recap: lessons we have learned

Author

Coccolini, Federico, Cicuttin, Enrico, Cremonini, Camilla, Tartaglia, Dario, Viaggi, Bruno, Kuriyama, Akira, Picetti, Edoardo, Ball, Chad, Abu-Zidan, Fikri, Ceresoli, Marco, Turri, Bruno, Jain, Sumita, Palombo, Carlo, Guirao, Xavier, Rodrigues, Gabriel, Gachabayov, Mahir, Machado, Fernando, Eftychios, Lostoridis, Kanj, Souha S., Di Carlo, Isidoro, Di Saverio, Salomone, Khokha, Vladimir, Kirkpatrick, Andrew, Massalou, Damien, Forfori, Francesco, Corradi, Francesco, Delibegovic, Samir, Machain Vega, Gustavo M., Fantoni, Massimo, Demetriades, Demetrios, Kapoor, Garima, Kluger, Yoram, Ansari, Shamshul, Maier, Ron, Leppaniemi, Ari, Hardcastle, Timothy, Vereczkei, Andras, Karamagioli, Evika, Pikoulis, Emmanouil, Pistello, Mauro, Sakakushev, Boris E., Navsaria, Pradeep H., Galeiras, Rita, Yahya, Ali I., Osipov, Aleksei V., Dimitrov, Evgeni, Doklestić, Krstina, Pisano, Michele, Malacarne, Paolo, Carcoforo, Paolo, Sibilla, Maria Grazia, Kryvoruchko, Igor A., Bonavina, Luigi, Kim, Jae Il, Shelat, Vishal G., Czepiel, Jacek, Maseda, Emilio, Marwah, Sanjay, Chirica, Mircea, Biancofiore, Giandomenico, Podda, Mauro, Cobianchi, Lorenzo, Ansaloni, Luca, Fugazzola, Paola, Seretis, Charalampos, Gomez, Carlos Augusto, Tumietto, Fabio, Malbrain, Manu, Reichert, Martin, Augustin, Goran, Amato, Bruno, Puzziello, Alessandro, Hecker, Andreas, Gemignani, Angelo, Isik, Arda, Cucchetti, Alessandro, Nacoti, Mirco, Kopelman, Doron, Mesina, Cristian, Ghannam, Wagih, Ben-Ishay, Offir, Dhingra, Sameer, Coimbra, Raul, Moore, Ernest E., Cui, Yunfeng, Quiodettis, Martha A., Bala, Miklosh, Testini, Mario, Diaz, Jose, Girardis, Massimo, Biffl, Walter L., Hecker, Matthias, Sall, Ibrahima, Boggi, Ugo, Materazzi, Gabriele, Ghiadoni, Lorenzo, Matsumoto, Junichi, Zuidema, Wietse P., Ivatury, Rao, Enani, Mushira A., Litvin, Andrey, Al-Hasan, Majdi N., Demetrashvili, Zaza, Baraket, Oussama, Ordoñez, Carlos A., Negoi, Ionut, Kiguba, Ronald, Memish, Ziad A., Elmangory, Mutasim M., Tolonen, Matti, Das, Korey, Ribeiro, Julival, O’Connor, Donal B., Tan, Boun Kim, Van Goor, Harry, Baral, Suman, De Simone, Belinda, Corbella, Davide, Brambillasca, Pietro, Scaglione, Michelangelo, Basolo, Fulvio, De’Angelis, Nicola, Bendinelli, Cino, Weber, Dieter, Pagani, Leonardo, Monti, Cinzia, Baiocchi, Gianluca, Chiarugi, Massimo, Catena, Fausto, and Sartelli, Massimo

Published
2021
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17. Antimicrobial consumption and resistance in adult hospital inpatients in 53 countries: results of an internet-based global point prevalence survey

Author

Koraqi, Andi, Hoxha, Iris, Tafaj, Silva, Lacej, Denada, Hojman, Martin, Quiros, Rodolfo Ernesto, Ghazaryan, Lilit, Cairns, Kelly A, Cheng, Allen, Horne, Kylie C, Doukas, Fiona F, Gottlieb, Thomas, Alsalman, Jameela, Magerman, Koen, Marielle, Gounongbe YT, Ljubovic, Amela Dedeic, Coelho, André Afonso Machado, Gales, Ana Cristina, Keuleyan, Emma, Sabuda, Deana, Boswell, Jennifer Lee, Conly, John M, Rojas, Alvaro, Carvajal, Camila, Labarca, Jaime, Solano, Antonio, Valverde, Carlos Ramírez, Villalobos-Vindas, Juan M, Pristas, Irina, Plecko, Vanda, Paphitou, Niki, Shaqiri, Erjona, Rummukainen, Maija-Liisa, Pagava, Karaman, Korinteli, Irma, Brandt, Tobias, Messler, Sabine, Enimil, Anthony, Iosifidis, Elias, Roilides, Emmanuel, Sow, Mamadou Saliou, Sengupta, Sharmila, George, Joby V, Poojary, Aruna, Patil, Priyanka, Soltani, Jafar, Jafarpour, Zahra, Ameen, Hadi, Fitzgerald, David, Maor, Yasmin, Chowers, Michal, Temkin, Elizabeth, Esposito, Susanna, Arnoldo, Luca, Brusaferro, Silvio, Gu, Yoshiaki, El-Hajji, Feras Darwish, Kim, Nam Joong, Kambaralieva, Baktygul, Pavare, Jana, Zarakauska, Lelde, Usonis, Vytautas, Burokiene, Sigita, Ivaskeviciene, Inga, Mijovic, Gordana, Duborija-Kovacevic, Natasa, Bondesio, Kristen, Iregbu, Kenneth, Oduyebo, Oyinlola, Raka, Denis, Raka, Lul, Rachina, Svetlana, Enani, Mushira Abdulaziz, Al Shehri, Mohamed, Carevic, Biljana, Dragovac, Gorana, Obradovic, Dusanka, Stojadinovic, Aleksandra, Radulovic, Lili, Wu, Jia EN, Wei Teng Chung, Gladys, Chen, Hui Hiong, Tambyah, Paul Anantharajah, Lye, David, Tan, Sock Hoon, Ng, Tat Ming, Tay, Hui Lin, Ling, Moi Lin, Chlebicki, Maciej Piotr, Kwa, Andrea L, Lee, Winnie, Beović, Bojana, Dramowski, Angela, Finlayson, Heather, Taljaard, Jantjie, Ojeda-Burgos, Guillermo, Retamar, Pilar, Lucas, Johan, Pot, Wolter, Verduin, Cees, Kluytmans, Jan, Scott, Michael, Aldeyab, Mamoon A, McCullagh, Bernadette, Gormley, Cairine, Sharpe, David, Gilchrist, Mark, Whitney, Laura, Laundy, Matthew, Lockwood, Debbie, Drysdale, Simon B, Boudreaux, Jennifer, Septimus, Edward J, Greer, Nickie, Gawrys, Gerard, Rios, Edgar, May, Suzanne, Versporten, Ann, Zarb, Peter, Caniaux, Isabelle, Gros, Marie-Françoise, Drapier, Nico, Miller, Mark, Jarlier, Vincent, Nathwani, Dilip, and Goossens, Herman

Published
2018
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18. Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study

Author

Sartelli, Massimo, Abu-Zidan, Fikri M., Labricciosa, Francesco M., Kluger, Yoram, Coccolini, Federico, Ansaloni, Luca, Leppäniemi, Ari, Kirkpatrick, Andrew W., Tolonen, Matti, Tranà, Cristian, Regimbeau, Jean-Marc, Hardcastle, Timothy, Koshy, Renol M., Abbas, Ashraf, Aday, Ulaş, Adesunkanmi, A. R. K., Ajibade, Adesina, Akhmeteli, Lali, Akın, Emrah, Akkapulu, Nezih, Alotaibi, Alhenouf, Altintoprak, Fatih, Anyfantakis, Dimitrios, Atanasov, Boyko, Augustin, Goran, Azevedo, Constança, Bala, Miklosh, Balalis, Dimitrios, Baraket, Oussama, Baral, Suman, Barkai, Or, Beltran, Marcelo, Bini, Roberto, Bouliaris, Konstantinos, Caballero, Ana B., Calu, Valentin, Catani, Marco, Ceresoli, Marco, Charalampakis, Vasileios, Jusoh, Asri Che, Chiarugi, Massimo, Cillara, Nicola, Cuesta, Raquel Cobos, Cobuccio, Luigi, Cocorullo, Gianfranco, Colak, Elif, Conti, Luigi, Cui, Yunfeng, De Simone, Belinda, Delibegovic, Samir, Demetrashvili, Zaza, Demetriades, Demetrios, Dimova, Ana, Dogjani, Agron, Enani, Mushira, Farina, Federica, Ferrara, Francesco, Foghetti, Domitilla, Fontana, Tommaso, Fraga, Gustavo P., Gachabayov, Mahir, Gérard, Grelpois, Ghnnam, Wagih, Maurel, Teresa Giménez, Gkiokas, Georgios, Gomes, Carlos A., Guner, Ali, Gupta, Sanjay, Hecker, Andreas, Hirano, Elcio S., Hodonou, Adrien, Hutan, Martin, Ilaschuk, Igor, Ioannidis, Orestis, Isik, Arda, Ivakhov, Georgy, Jain, Sumita, Jokubauskas, Mantas, Karamarkovic, Aleksandar, Kaushik, Robin, Kenig, Jakub, Khokha, Vladimir, Khokha, Denis, Kim, Jae Il, Kong, Victor, Korkolis, Dimitris, Kruger, Vitor F., Kshirsagar, Ashok, Simões, Romeo Lages, Lanaia, Andrea, Lasithiotakis, Konstantinos, Leão, Pedro, Arellano, Miguel León, Listle, Holger, Litvin, Andrey, Lizarazu Pérez, Aintzane, Lopez-Tomassetti Fernandez, Eudaldo, Lostoridis, Eftychios, Luppi, Davide, Machain V, Gustavo M., Major, Piotr, Manatakis, Dimitrios, Reitz, Marianne Marchini, Marinis, Athanasios, Marrelli, Daniele, Martínez-Pérez, Aleix, Marwah, Sanjay, McFarlane, Michael, Mesic, Mirza, Mesina, Cristian, Michalopoulos, Nickos, Misiakos, Evangelos, Moreira, Felipe Gonçalves, Mouaqit, Ouadii, Muhtaroglu, Ali, Naidoo, Noel, Negoi, Ionut, Nikitina, Zane, Nikolopoulos, Ioannis, Nita, Gabriela-Elisa, Occhionorelli, Savino, Olaoye, Iyiade, Ordoñez, Carlos A., Ozkan, Zeynep, Pal, Ajay, Palini, Gian M., Papageorgiou, Kyriaki, Papagoras, Dimitris, Pata, Francesco, Pędziwiatr, Michał, Pereira, Jorge, Pereira Junior, Gerson A., Perrone, Gennaro, Pintar, Tadeja, Pisarska, Magdalena, Plehutsa, Oleksandr, Podda, Mauro, Poillucci, Gaetano, Quiodettis, Martha, Rahim, Tuba, Rios-Cruz, Daniel, Rodrigues, Gabriel, Rozov, Dmytry, Sakakushev, Boris, Sall, Ibrahima, Sazhin, Alexander, Semião, Miguel, Sharda, Taanya, Shelat, Vishal, Sinibaldi, Giovanni, Skicko, Dmitrijs, Skrovina, Matej, Stamatiou, Dimitrios, Stella, Marco, Strzałka, Marcin, Sydorchuk, Ruslan, Teixeira Gonsaga, Ricardo A., Tochie, Joel Noutakdie, Tomadze, Gia, Ugoletti, Lara, Ulrych, Jan, Ümarik, Toomas, Uzunoglu, Mustafa Y., Vasilescu, Alin, Vaz, Osborne, Vereczkei, Andras, Vlad, Nutu, Walędziak, Maciej, Yahya, Ali I., Yalkin, Omer, Yilmaz, Tonguç U., Ünal, Ali Ekrem, Yuan, Kuo-Ching, Zachariah, Sanoop K., Žilinskas, Justas, Zizzo, Maurizio, Pattonieri, Vittoria, Baiocchi, Gian Luca, and Catena, Fausto

Published
2019
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20. Evaluation of 34 Cytokines and Vitamin D Status Reveal A Sexually-Dimorphic Active Immune Response to SARS-CoV-2

Author

Amer, Osama E., primary, Sabico, Shaun, additional, Sheshah, Eman, additional, Alotaibi, Naif H, additional, Aldisi, Dara A., additional, Enani, Mushira A., additional, Aljohani, Naji J., additional, Alshingetti, Naemah, additional, Alomar, Suliman Y., additional, Hussain, Syed D., additional, Alnaami, Abdullah M., additional, Elsaid, Mohamed A., additional, and Al-Daghri, Nasser M., additional

Published
2022
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21. Moderately Low Effectiveness of the Influenza Quadrivalent Vaccine: Potential Mismatch between Circulating Strains and Vaccine Strains.

Author

Awadalla, Maaweya E., Alkadi, Haitham, Alarjani, Modhi, Al-Anazi, Abdullah E., Ibrahim, Mohanad A., ALOhali, Thamer Ahmad, Enani, Mushira, Alturaiki, Wael, and Alosaimi, Bandar

Subjects
FLU vaccine efficacy, SEASONAL influenza, VACCINE effectiveness, INFLUENZA viruses, INFLUENZA vaccines
Abstract

The annual seasonal influenza vaccination is the most effective way of preventing influenza illness and hospitalization. However, the effectiveness of influenza vaccines has always been controversial. Therefore, we investigated the ability of the quadrivalent influenza vaccine to induce effective protection. Here we report strain-specific influenza vaccine effectiveness (VE) against laboratory-confirmed influenza cases during the 2019/2020 season, characterized by the co-circulation of four different influenza strains. During 2019–2020, 778 influenza-like illness (ILI) samples were collected from 302 (39%) vaccinated ILI patients and 476 (61%) unvaccinated ILI patients in Riyadh, Saudi Arabia. VE was found to be 28% and 22% for influenza A and B, respectively. VE for preventing A(H3N2) and A(H1N1)pdm09 illness was 37.4% (95% CI: 43.7–54.3) and 39.2% (95% CI: 21.1–28.9), respectively. The VE for preventing influenza B Victoria lineage illness was 71.7% (95% CI: −0.9–3), while the VE for the Yamagata lineage could not be estimated due to the limited number of positive cases. The overall vaccine effectiveness was moderately low at 39.7%. Phylogenetic analysis revealed that most of the Flu A genotypes in our dataset clustered together, indicating their close genetic relatedness. In the post-COVID-19 pandemic, flu B-positive cases have reached three-quarters of the total number of influenza-positive cases, indicating a nationwide flu B surge. The reasons for this phenomenon, if related to the quadrivalent flu VE, need to be explored. Annual monitoring and genetic characterization of circulating influenza viruses are important to support Influenza surveillance systems and to improve influenza vaccine effectiveness. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Hospital antibiotic prescribing patterns in adult patients according to the WHO Access, Watch and Reserve classification (AWaRe): results from a worldwide point prevalence survey in 69 countries

Author

Pauwels, Ines, Versporten, Ann, Drapier, Nico, Vlieghe, Erika, Goossens, Herman, Koraqi, Andi, Hoxha, Iris, Tafaj, Silva, Cornistein, Wanda, Quiros, Rodolfo, Hojman, Martin, Ghazaryan, Lilit, Horne, Kylie, Cairns, Kelly, Doukas, Fiona, Gottlieb, Thomas, Sermijn, Erica, Verhamme, Katia, Brands, Christiane, Van Herendael, Bruno, Filippin, Lorenzo, Vandewal, Wouter, Konopnicki, Deborah, Maillart, Evelyne, Teixeira Lopes, Liliana, Papin, Pauline, Smits, Ilse, Jansens, Hilde, Bartholomeus, Sofie, Van den Abeele, Anne-Marie, Steyaert, Sophia, Piette, Anne, Buyle, Franky, Cartuyvels, Reinoud, Jonckheere, Stijn, Wybo, Ingrid, Vanneste, Lorenz, Mathieu, Delphine, Firre, Eric, Westelinck, Veerle, Gadisseux, Philippe, Dugernier, Thierry, Bafort, Kristof, Gonissen, Viviane, Vanderper, Vanessa, Gabriels, Patrick, Weekers, Frank, Michel, Philippe, Van Liedekerke, Ann, Costers, Michiel, Catry, Boudewijn, Dedeic-Ljubovic, Amela, Gales, Ana C., Matos Porto, Ana Paula, Figueiredo Costa, Silvia, Keuleyan, Emma, Beidi, Apollinaire, Cissohko, Youssouph, Blakwe, Habsatou, Batchaya Basile, Ngassa, German, Greg J., Lutes, Sarah, Boswell, Jennifer, Mertz, Dominik, Nguyen, Tuyen, MacLaggan, Timothy, Landry, Daniel, Ang, Anita, Thirion, Daniel J.G., Frenette, Charles, Émond, Yannick, Roberts, Jacqueline, Chang, Sandra, Kosar, Justin, Valiquette, Louis, Dutrisac, Ginette, Afra, Kevin, McGeer, Allison, Carrier, Marie, Grant, Jennifer, Labarca, Jaime, Carvajal, Camila, Lin, HongYi, Wang, Qiang, Yang, Jing, Yang, Wenjie, Cortes, Jorge A., Villalobos-Vindas, Juan, Ramírez-Valverde, Carlos, Horvatic, Jasminka, Pristas, Irina, Paphitou, Niki, Rummukainen, Maija-Liisa, Froissart, Antoine, Vanhems, Philippe, Pagava, Karaman, Korinteli, Irma, Brandt, Tobias, Gaertner, Johannes, Enimil, Anthony, Roilides, Emmanuel, Hajdú, Edit, Sengupta, Sharmila, Singh, Sanjeev, Patil, Priyanka, Poojary, Aruna, Soltani, Jafar, Pouladfar, Gholamreza, Jafarpour, Zahra, Alinia, Cyrus, Ameen, Hadi, Fitzgerald, David, Paul, Mical, Maor, Yasmin, Strahilevitz, Jacob, Chowers, Michal, Temkin, Elizabeth, Luca, Arnoldo, Ishibashi, Noriomi, Gu, Yoshiaki, Darwish Elhajji, Feras, Karabukayeva, Aizhan, Raka, Denis, Kambaralieva, Baktygul, Zarakauska, Lelde, Zarb, Peter, Hernandez Chena, Blanca Estela, Gonzalez-Diaz, Esteban, Corona-Meléndez, JuanCarlos, Torres Erazo, Darwin Stalin, Loza-Jalil, Suria Elizabeth, Molina, Julio, Candelas, Jose Antonio, Mijovic, Gordana, Duborija-Kovacevic, Natasa, Jong, Eefje, Kluytmans, Jan, van Elzakker, Erika, Schweitzer, Valentijn, Davies, Nicola, Iregbu, Kenneth, Nwajiobi-Princewill, Philip, Nwafia, Ifeyinwa, Fasuyi, Temitayo, Aboderin, Aaron, Elikwu, Charles John, Fadeyi, Abayomi, Ola-Bello, Olafoyekemi, Oduyebo, Oyinlola, Adedosu, Akin Nelson, Ekuma, Agantem, Shaqiri, Erjona, Saleem, Zikria, De Los Reyes, Mari Rose, Tavares, Luis, Kim, Nam Joong, Rachina, Svetlana, Alharthi, Alwaleed R., Enani, Mushira, Faried, Osama, Mirghani, Mohamed, Carevic, Biljana, Radulovic, Lili, Dragovac, Gorana, Tan, Sock Hoon, Taljaard, Jantjie, Chibabhai, Vindana, Joiner, Jennifer, Caston, Juan Jose, Núñez-Núñez, María, Martínez-Marcos, Francisco Javier, Ojeda-Burgos, Guillermo, Menendez, Maria Dolores, Retamar, Pilar, Corzo, Juan E., Rattanaumpawan, Pinyo, Salou, Mounerou, Mnif, Basma, Oncul, Ahsen, Babigumira, Peter Ahabwe, Olweny, James, Marshall, Emily, McCorry, Ann, Aldeyab, Mamoon, Khanna, Priya, Gormley, Cairine, Maloney, Sara, Cooper, Mandelin, Blackburn, Laura, Gessner-Wharton, Mallory, Vu, Lam, Greer, Nickie, Gawrys, Gerard, Kronmann, Lisha, Rios, Edgar, Hudson, Melissa, Lindholm, David A., The Global-PPS network, Vriendenkring VUB, Clinical sciences, Microbiology and Infection Control, and Clinical Biology

Subjects
Adult, Microbiology (medical), Point prevalence survey, Latin Americans, education, Population, MEDLINE, World Health Organization, Essential medicines, Antibiotic prescribing, Anti-Infective Agents, Environmental health, Prevalence, Humans, AcademicSubjects/MED00740, Medicine, Pharmacology (medical), Medical prescription, Biology, Original Research, Pharmacology, education.field_of_study, Adult patients, business.industry, Pharmacology. Therapy, Hospitals, Anti-Bacterial Agents, Anti-Bacterial Agents/therapeutic use, AcademicSubjects/MED00290, Infectious Diseases, Human medicine, AcademicSubjects/MED00230, business
Abstract

ObjectivesThe WHO Access, Watch and Reserve (AWaRe) classification has been developed to support countries and hospitals in promoting rational use of antibiotics while improving access to these essential medicines. We aimed to describe patterns of worldwide antibiotic use according to the AWaRe classification in the adult inpatient population.MethodsThe Global Point Prevalence Survey on Antimicrobial Consumption and Resistance (Global-PPS) collects hospital antibiotic use data using a standardized PPS methodology. Global-PPS 2015, 2017 and 2018 data, collected by 664 hospitals in 69 countries, were categorized into AWaRe groups to calculate proportional AWaRe use, Access-to-Watch ratios and the most common indications for treatment with selected Watch antibiotics. Only prescriptions for systemic antibiotics on adult inpatient wards were analysed.ResultsRegional Access use ranged from 28.4% in West and Central Asia to 57.7% in Oceania, whereas Watch use was lowest in Oceania (41.3%) and highest in West and Central Asia (66.1%). Reserve use ranged from 0.03% in sub-Saharan Africa to 4.7% in Latin America. There were large differences in AWaRe prescribing at country level. Watch antibiotics were prescribed for a range of very different indications worldwide, both for therapeutic and prophylactic use.ConclusionsWe observed considerable variations in AWaRe prescribing and high use of Watch antibiotics, particularly in lower- and upper-middle-income countries, followed by high-income countries. The WHO AWaRe classification has an instrumental role to play in local and national stewardship activities to assess prescribing patterns and to inform and evaluate stewardship activities.

Published
2021

25. Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial

Author

Sabico, Shaun, primary, Enani, Mushira A., additional, Sheshah, Eman, additional, Aljohani, Naji J., additional, Aldisi, Dara A., additional, Alotaibi, Naif H., additional, Alshingetti, Naemah, additional, Alomar, Suliman Y., additional, Alnaami, Abdullah M., additional, Amer, Osama E., additional, Hussain, Syed D., additional, and Al-Daghri, Nasser M., additional

Published
2021
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27. The Saudi Critical Care Society Practice Guidelines on the Management of COVID-19 in the ICU: Therapy Section

Author

Alhazzani, Waleed, primary, Alshahrani, Mohammed, additional, Alshamsi, Fayez, additional, Aljuhani, Ohoud, additional, Eljaaly, Khalid, additional, Hashim, Samaher, additional, Alqahtani, Rakan, additional, Alsaleh, Doaa, additional, Duhailib, Zainab Al, additional, Algethamy, Haifa, additional, Al-Musawi, Tariq, additional, Alshammari, Thamir, additional, Alqarni, Abdullah, additional, Khoujah, Danya, additional, Tashkandi, Wail, additional, Dahhan, Talal, additional, Almutairi, Najla, additional, Alserehi, Haleema A., additional, Al-Yahya, Maytha, additional, Al-Judaibi, Bandar, additional, Arabi, Yaseen M, additional, Abualenain, Jameel, additional, Alotaibi, Jawaher M., additional, Albshabshe, Ali, additional, Alharbi, Reham, additional, Al-Hameed, Fahad, additional, Elhazmi, Alyaa, additional, Almaghrabi, Reem S., additional, Almaghlouth, Fatma, additional, Abedalthagafi, Malak, additional, Khathlan, Noor Al, additional, Al-Suwaidan, Faisal A., additional, Bunyan, Reem F., additional, Baw, Bandar, additional, Alghamdi, Ghassan, additional, Hazmi, Manal Al, additional, Mandourah, Yasser, additional, Assiri, Abdullah, additional, Enani, Mushira, additional, Alawi, Maha, additional, Aljindan, Reem, additional, Aljabbary, Ahmed, additional, Alrbiaan, Abdullah, additional, Algurashi, Fahd, additional, Alsaawi, Abdulmohsen, additional, Alenazi, Thamer H., additional, Alsultan, Mohammed A., additional, Alqahtani, Saleh A., additional, Memish, Ziad, additional, Al-Tawfiq, Jaffar A., additional, and Al-Jedai, Ahmed, additional

Published
2021
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28. A pandemic recap: lessons we have learned

Author

Coccolini, Federico Cicuttin, Enrico Cremonini, Camilla and Tartaglia, Dario Viaggi, Bruno Kuriyama, Akira Picetti, Edoardo Ball, Chad Abu-Zidan, Fikri Ceresoli, Marco and Turri, Bruno Jain, Sumita Palombo, Carlo Guirao, Xavier and Rodrigues, Gabriel Gachabayov, Mahir Machado, Fernando and Eftychios, Lostoridis Kanj, Souha S. Di Carlo, Isidoro Di Saverio, Salomone Khokha, Vladimir Kirkpatrick, Andrew and Massalou, Damien Forfori, Francesco Corradi, Francesco and Delibegovic, Samir Machain Vega, Gustavo M. Fantoni, Massimo and Demetriades, Demetrios Kapoor, Garima Kluger, Yoram Ansari, Shamshul Maier, Ron Leppaniemi, Ari Hardcastle, Timothy and Vereczkei, Andras Karamagioli, Evika Pikoulis, Emmanouil and Pistello, Mauro Sakakushev, Boris E. Navsaria, Pradeep H. and Galeiras, Rita Yahya, Ali I. Osipov, Aleksei V. Dimitrov, Evgeni Doklestic, Krstina Pisano, Michele Malacarne, Paolo and Carcoforo, Paolo Sibilla, Maria Grazia Kryvoruchko, Igor A. and Bonavina, Luigi Kim, Jae Il Shelat, Vishal G. Czepiel, Jacek Maseda, Emilio Marwah, Sanjay Chirica, Mircea and Biancofiore, Giandomenico Podda, Mauro Cobianchi, Lorenzo and Ansaloni, Luca Fugazzola, Paola Seretis, Charalampos Gomez, Carlos Augusto Tumietto, Fabio Malbrain, Manu Reichert, Martin Augustin, Goran Amato, Bruno Puzziello, Alessandro and Hecker, Andreas Gemignani, Angelo Isik, Arda Cucchetti, Alessandro Nacoti, Mirco Kopelman, Doron Mesina, Cristian and Ghannam, Wagih Ben-Ishay, Offir Dhingra, Sameer Coimbra, Raul Moore, Ernest E. Cui, Yunfeng Quiodettis, Martha A. and Bala, Miklosh Testini, Mario Diaz, Jose Girardis, Massimo and Biffl, Walter L. Hecker, Matthias Sall, Ibrahima Boggi, Ugo Materazzi, Gabriele Ghiadoni, Lorenzo Matsumoto, Junichi and Zuidema, Wietse P. Ivatury, Rao Enani, Mushira A. and Litvin, Andrey Al-Hasan, Majdi N. Demetrashvili, Zaza and Baraket, Oussama Ordonez, Carlos A. Negoi, Ionut Kiguba, Ronald Memish, Ziad A. Elmangory, Mutasim M. Tolonen, Matti and Das, Korey Ribeiro, Julival O'Connor, Donal B. Tan, Boun Kim Van Goor, Harry Baral, Suman De Simone, Belinda and Corbella, Davide Brambillasca, Pietro Scaglione, Michelangelo and Basolo, Fulvio De'Angelis, Nicola Bendinelli, Cino and Weber, Dieter Pagani, Leonardo Monti, Cinzia Baiocchi, Gianluca Chiarugi, Massimo Catena, Fausto Sartelli, Massimo

Abstract

On January 2020, the WHO Director General declared that the outbreak constitutes a Public Health Emergency of International Concern. The world has faced a worldwide spread crisis and is still dealing with it. The present paper represents a white paper concerning the tough lessons we have learned from the COVID-19 pandemic. Thus, an international and heterogenous multidisciplinary panel of very differentiated people would like to share global experiences and lessons with all interested and especially those responsible for future healthcare decision making. With the present paper, international and heterogenous multidisciplinary panel of very differentiated people would like to share global experiences and lessons with all interested and especially those responsible for future healthcare decision making.

Published
2021

29. WSES/GAIS/SIS-E/WSIS/AAST global clinical pathways for patients with intra-abdominal infections

Author

Sartelli, Massimo Coccolini, Federico Kluger, Yoram Agastra, Ervis Abu-Zidan, Fikri M. Abbas, Ashraf El Sayed Ansaloni, Luca Adesunkanmi, Abdulrashid Kayode Atanasov, Boyko and Augustin, Goran Bala, Miklosh Baraket, Oussama Baral, Suman and Biffl, Walter L. Boermeester, Marja A. Ceresoli, Marco and Cerutti, Elisabetta Chiara, Osvaldo Cicuttin, Enrico and Chiarugi, Massimo Coimbra, Raul Colak, Elif Corsi, Daniela and Cortese, Francesco Cui, Yunfeng Damaskos, Dimitris and Angelis, Nicola De' Delibegovic, Samir Demetrashvili, Zaza and De Simone, Belinda de Jonge, Stijn W. Dhingra, Sameer Di Bella, Stefano Di Marzo, Francesco Di Saverio, Salomone and Dogjani, Agron Duane, Therese M. Enani, Mushira Abdulaziz and Fugazzola, Paola Galante, Joseph M. Gachabayov, Mahir and Ghnnam, Wagih Gkiokas, George Gomes, Carlos Augusto and Griffiths, Ewen A. Hardcastle, Timothy C. Hecker, Andreas and Herzog, Torsten Kabir, Syed Mohammad Umar Karamarkovic, Aleksandar Khokha, Vladimir Kim, Peter K. Il Kim, Jae and Kirkpatrick, Andrew W. Kong, Victor Koshy, Renol M. and Kryvoruchko, Igor A. Inaba, Kenji Isik, Arda Iskandar, Katia and Ivatury, Rao Labricciosa, Francesco M. Lee, Yeong Yeh and Leppaniemi, Ari Litvin, Andrey Luppi, Davide Machain, Gustavo M. Maier, V, Ronald Marinis, Athanasios Marmorale, Cristina Marwah, Sanjay Mesina, Cristian Moore, Ernest E. and Moore, Frederick A. Negoi, Ionut Olaoye, Iyiade Ordonez, Carlos A. Ouadii, Mouaqit Peitzman, Andrew B. Perrone, Gennaro Pikoulis, Manos Pintar, Tadeja Pipitone, Giuseppe and Podda, Mauro Rasa, Kemal Ribeiro, Julival Rodrigues, Gabriel Rubio-Perez, Ines Sall, Ibrahima Sato, Norio and Sawyer, Robert G. Lohse, Helmut Segovia Sganga, Gabriele and Shelat, Vishal G. Stephens, Ian Sugrue, Michael Tarasconi, Antonio Tochie, Joel Noutakdie Tolonen, Matti Tomadze, Gia and Ulrych, Jan Vereczkei, Andras Viaggi, Bruno Gurioli, Chiara Casella, Claudio Pagani, Leonardo Baiocchi, Gian Luca and Catena, Fausto

Subjects
embryonic structures
Abstract

Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported as major contributors to non-trauma deaths in hospitals worldwide. The cornerstones of effective treatment of IAIs include early recognition, adequate source control, appropriate antimicrobial therapy, and prompt physiologic stabilization using a critical care environment, combined with an optimal surgical approach. Together, the World Society of Emergency Surgery (WSES), the Global Alliance for Infections in Surgery (GAIS), the Surgical Infection Society-Europe (SIS-E), the World Surgical Infection Society (WSIS), and the American Association for the Surgery of Trauma (AAST) have jointly completed an international multi-society document in order to facilitate clinical management of patients with IAIs worldwide building evidence-based clinical pathways for the most common IAIs. An extensive non-systematic review was conducted using the PubMed and MEDLINE databases, limited to the English language. The resulting information was shared by an international task force from 46 countries with different clinical backgrounds. The aim of the document is to promote global standards of care in IAIs providing guidance to clinicians by describing reasonable approaches to the management of IAIs.

Published
2021

31. Elevated Expression Levels of Lung Complement Anaphylatoxin, Neutrophil Chemoattractant Chemokine IL-8, and RANTES in MERS-CoV-Infected Patients: Predictive Biomarkers for Disease Severity and Mortality

Author

Awadalla, Maaweya, primary, Naeem, Asif, additional, Alkadi, Haitham, additional, Alamri, Aref A., additional, AlYami, Ahmad S., additional, AlJuryyan, Abdullah, additional, Alturaiki, Wael, additional, Enani, Mushira, additional, Al-Shouli, Samia Towfeek, additional, Assiri, Abdullah M., additional, and Alosaimi, Bandar, additional

Published
2021
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32. Advocacy for Increased International Efforts for Antimicrobial Stewardship Actions in Low-and Middle-Income Countries on Behalf of Alliance for the Prudent Use of Antimicrobials (APUA), Under the Auspices of the International Society of Antimicrobial Chemotherapy (ISAC)

Author

Tattevin, Pierre, Levy Hara, Gabriel, Toumi, Adnene, Enani, Mushira, Coombs, G.W., Voss, A., Wertheim, H.F.L., Nathwani, Dilip, and Gould, Ian

Subjects
All institutes and research themes of the Radboud University Medical Center, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]
Abstract

Contains fulltext : 226149.pdf (Publisher’s version ) (Open Access)

Published
2020

33. Multidrug-Resistant and Extensively Drug-Resistant Enterobacteriaceae: Prevalence, Treatments, and Outcomes – A Retrospective Cohort Study

Author

Alkofide,Hadeel, Alhammad,Abdullah M, Alruwaili,Alya, Aldemerdash,Ahmed, Almangour,Thamer A, Alsuwayegh,Aseel, Almoqbel,Daad, Albati,Aljohara, Alsaud,Aljohara, Enani,Mushira, Alkofide,Hadeel, Alhammad,Abdullah M, Alruwaili,Alya, Aldemerdash,Ahmed, Almangour,Thamer A, Alsuwayegh,Aseel, Almoqbel,Daad, Albati,Aljohara, Alsaud,Aljohara, and Enani,Mushira

Abstract

Hadeel Alkofide,1 Abdullah M Alhammad,1,2 Alya Alruwaili,3 Ahmed Aldemerdash,1 Thamer A Almangour,1 Aseel Alsuwayegh,2 Daad Almoqbel,4 Aljohara Albati,5 Aljohara Alsaud,6 Mushira Enani7 1Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 2Department of Pharmacy Services, King Khalid University Hospital – King Saud University Medical City, Riyadh, Saudi Arabia; 3Department of Clinical Pharmacy, Pharmacy Services Administration, King Fahad Medical City, Riyadh, Saudi Arabia; 4Credit Department, Saudi Industrial Development Fund, Riyadh, Saudi Arabia; 5Benefit Risk Assessment Department, Saudi Food and Drug Authority, Riyadh, Saudi Arabia; 6Biomedical Sciences, Alfaisal University, Riyadh, Saudi Arabia; 7Infectious Diseases Section, King Fahad Medical City, Riyadh, Saudi ArabiaCorrespondence: Hadeel Alkofide Department of Clinical PharmacyKing Saud University, College of Pharmacy, Riyadh 11149, Saudi ArabiaTel +966503225121Email halkofide@ksu.edu.saBackground: Drug-resistant gram-negative bacteria (GNB) are a global public health threat, especially in intensive care units (ICU). This study explored the prevalence of drug-resistant Enterobacteriaceae infections in an ICU in Saudi Arabia. The appropriateness of the antibiotic therapies used and their ability to improve the clinical outcomes were also assessed.Methods: A retrospective study was conducted from 2015 to 2018 in the different ICUs of a tertiary-care hospital in Saudi Arabia. Positive cultures for multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) Enterobacteriaceae, including Klebsiella pneumoniae, Escherichia coli, and Enterobacter sp., were included. The primary outcomes involved microbiological cure and 30 days in-hospital mortality rate, while the secondary outcome included the length of hospital stay (LOS). Regression models were used to assess the relationship between appropriateness of the antibiotic therapy

Published
2020

37. Severity of COVID-19 Infection in ACEI/ARB Users in Two Saudi Public Specialty Hospitals: Retrospective Cohort Study

Author

Alrashed, Ahmed A., primary, Khan, Tahir, additional, Alhusseini, Noara, additional, Asdaq, Syed Mohammed, additional, Enani, Mushira, additional, Alosaimi, Bandar, additional, Alkhani, Nada, additional, Mohzari, Yahya, additional, Alghalbi, Maram, additional, Alfahad, Wafa, additional, Alanazi, Mona, additional, Albujaidya, Asma, additional, Ben-Akresh, Amal, additional, Almutairi, Malak, additional, Abraham, Ivo, additional, and Alamer, Ahmad, additional

Published
2020
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38. Multidrug-Resistant and Extensively Drug-Resistant Enterobacteriaceae: Prevalence, Treatments, and Outcomes – A Retrospective Cohort Study

Author

Alkofide, Hadeel, primary, Alhammad, Abdullah M, additional, Alruwaili, Alya, additional, Aldemerdash, Ahmed, additional, Almangour, Thamer A, additional, Alsuwayegh, Aseel, additional, Almoqbel, Daad, additional, Albati, Aljohara, additional, Alsaud, Aljohara, additional, and Enani, Mushira, additional

Published
2020
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39. Management of infections caused by WHO critical priority Gram-negative pathogens in Arab countries of the Middle East: a consensus paper

Author

Al Salman, Jameela, primary, Al Dabal, Laila, additional, Bassetti, Matteo, additional, Alfouzan, Wadha A., additional, Al Maslamani, Muna, additional, Alraddadi, Basem, additional, Elhoufi, Ashraf, additional, Enani, Mushira, additional, Khamis, Faryal Ali, additional, Mokkadas, Eiman, additional, Romany, Ingy, additional, Somily, Ali, additional, and Kanj, Souha, additional

Published
2020
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43. MERS-CoV infection is associated with downregulation of genes encoding Th1 and Th2 cytokines/chemokines and elevated inflammatory innate immune response in the lower respiratory tract

Author

Alosaimi, Bandar, primary, Hamed, Maaweya E., additional, Naeem, Asif, additional, Alsharef, Ali A., additional, AlQahtani, Saeed Y., additional, AlDosari, Kamel M., additional, Alamri, Aref A., additional, Al-Eisa, Kholoud, additional, Khojah, Taghreed, additional, Assiri, Abdullah M., additional, and Enani, Mushira A., additional

Published
2020
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45. Essential and Forgotten antibiotics: an inventory in low- and middle-income countries

Author

Tebano, Gianpiero, Li, Grace, Beovic, Bojana, Bielicki, Julia, Brink, Adrian, Enani, Mushira A, Godman, Brian, Hinrichsen, Sylvia Lemos, Kibuule, Dan, Gabriel, Levy-Hara, Oduyebo, Oyinlola, Sharland, Mike, Singh, Sanjeev, Wertheim, Heiman FL, Nathwani, Dilip, Pulcini, Celine, In, European Soc Clinical Microbiol, Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Paediatric Infectious Diseases Research Group [London, UK], St George's, University of London-Institute for Infection and Immunity [London, UK], University of Ljubljana, University of Cape Town, King Fahad Medical City, Karolinska Institutet [Stockholm], Universidade Federal de Pernambuco [Recife] (UFPE), University of Namibia, Hospital Carlos G. Durand, University of Lagos, Amrita Institute of Medical Sciences and Research Center, Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Oxford University Clinical Research Unit [Ho Chi Minh City] (OUCRU), University of Dundee, Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université de Lorraine (UL), Service des Maladies Infectieuses et Tropicales [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CCSD, Accord Elsevier, Service de Maladies Infectieuses et Tropicales [CHU Pitié-Salpêtrière], King Fahad Medical City [Riyadh] (KFMC), and University of Namibia (UNAM)

Subjects
0301 basic medicine, Microbiology (medical), medicine.medical_specialty, medicine.drug_class, 030106 microbiology, Antibiotics, Global Health, World Health Organization, Communicable Diseases, Essential medicines, RS, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, Ampicillin, Prevalence, Global health, medicine, Humans, Antimicrobial stewardship, Pharmacology (medical), 030212 general & internal medicine, Survey, Developing Countries, Antibiotic stewardship, Low- and middle-income countries, business.industry, General Medicine, Amoxicillin, Access, Anti-Bacterial Agents, 3. Good health, Penicillin, Metronidazole, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Infectious Diseases, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Family medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, medicine.drug, Antibiotic access
Abstract

Background The World Health Organization Essential Medicines List (WHO-EML) includes ‘access’ antibiotics, judged essential to treat common infections. The European Society of Clinical Microbiology and Infectious Diseases Study Group for Antimicrobial Stewardship defined a list of ‘forgotten’ antibiotics, some old and often off-patent antibiotics, which have particular value for specific indications. Objective To investigate which WHO-EML ‘access’ and ‘forgotten’ antibiotics are approved at national level in a sample of low- to middle-income countries (LMICs). Methods The Scientific Committee used a consensus procedure to select 26 WHO-EML ‘access’ and 15 ‘forgotten’ antibiotics. Paediatric formulations were explored for 14 antibiotics. An internet-based questionnaire was circulated to 40 LMIC representatives. Antibiotics were defined as approved if an official drug regulatory agency and/or the national ministry of health licensed their use, making them, at least theoretically, available on the market. Results Twenty-eight LMICs (11 in Africa, 11 in Asia and six in America) were surveyed. Nine WHO-EML ‘access’ antibiotics (amoxicillin, ampicillin, benzylpenicillin, ceftriaxone, clarithromycin, ciprofloxacin, doxycycline, gentamicin and metronidazole) were approved in all countries, and all 26 ‘access’ antibiotics were approved in more than two-thirds of countries. Among the 15 ‘forgotten’ antibiotics, only one was approved in more than two-thirds of countries. The median number of approved antibiotics per country was 30 (interquartile range 23–35). Six of 14 paediatric formulations (amoxicillin, amoxicillin-clavulanic acid, oral antistaphylococcal penicillin, cotrimoxazole, erythromycin and metronidazole) were approved in more than two-thirds of countries. Conclusions WHO-EML ‘access’ antibiotics and the most frequently used formulations for paediatrics were approved in the vast majority of the 28 surveyed LMICs. This was not the case for many of the ‘forgotten’ antibiotics, despite their important role, particularly in areas with high prevalence of multi-drug-resistant bacteria.

Published
2019

47. Nanomedical Relevance of the Intermolecular Interaction Dynamics—Examples from Lysozymes and Insulins

Author

Zhang, Ruiyan, primary, Zhang, Ning, additional, Mohri, Marzieh, additional, Wu, Lisha, additional, Eckert, Thomas, additional, Krylov, Vadim B., additional, Antosova, Andrea, additional, Ponikova, Slavomira, additional, Bednarikova, Zuzana, additional, Markart, Philipp, additional, Günther, Andreas, additional, Norden, Bengt, additional, Billeter, Martin, additional, Schauer, Roland, additional, Scheidig, Axel J., additional, Ratha, Bhisma N., additional, Bhunia, Anirban, additional, Hesse, Karsten, additional, Enani, Mushira Abdelaziz, additional, Steinmeyer, Jürgen, additional, Petridis, Athanasios K., additional, Kozar, Tibor, additional, Gazova, Zuzana, additional, Nifantiev, Nikolay E., additional, and Siebert, Hans-Christian, additional

Published
2019
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48. Raising concerns about the Sepsis-3 definitions

Author

Universitat Rovira i Virgili, Catena, Fausto, Yuan, Kuo-Ching, Ulrych, Jan, Trana, Cristian, Talving, Peep, Siribumrungwong, Boonying, Shah, Jay N., Sato, Norio, Kafil, Hossein Samadi, Sakakushev, Boris, Reis, Tarcisio, Pupelis, Guntars, Ponce-de-Leon, Alfredo, Pintar, Tadeja, Picetti, Edoardo, Paolillo, Ciro, Ouadii, Mouaqit, Ordonez, Carlos A., Olaoye, Iyiade, Ofori-Asenso, Richard, Negoi, Ionut, Naidoo, Noel, Moore, Frederick A., Moore, Ernest E., Mesina, Cristian, Memish, Ziad A., McFarlane, Michael, Marwah, Sanjay, Major, Piotr, Manzano-Nunez, Ramiro, Machain, Gustavo M., Litvin, Andrey, Lee, Jae G., Latifi, Rifat, Labricciosa, Francesco M., Isik, Arda, Kok, Kenneth Y. Y., Koike, Kaoru, Khokha, Vladimir, Khamis, Faryal, Kenig, Jakub, Karamarkovic, Aleksandar, Kanj, Souha S., Gomes, Carlos A., Ghnnam, Wagih, Frattima, Sabrina, Fraga, Gustavo P., Ferrada, Paula, Enani, Mushira A., Elmangory, Mutasim M., Dogjani, Agron, Di Saverio, Salomone, Diaz, Jose J., Dhingra, Sameer, Davies, R. Justin, Cui, Yunfeng, de Souza, Hamilton P., De Simone, Belinda, Demetrashvili, Zaza, Jusoh, Asri Che, Beltran, Marcelo A., Baraket, Oussema, Bala, Miklosh, Baiocchi, Gian L., Augustin, Goran, Adesunkanmi, Abdulrashid K., Abu-Zidan, Fikri M., Coccolini, Federico, Giamarellou, Eleni, Bassetti, Matteo, Watkins, Richard R., Rello, Jordi, Hardcastle, Timothy C., Ansaloni, Luca, Kluger, Yoram, Sartelli, Massimo, Universitat Rovira i Virgili, Catena, Fausto, Yuan, Kuo-Ching, Ulrych, Jan, Trana, Cristian, Talving, Peep, Siribumrungwong, Boonying, Shah, Jay N., Sato, Norio, Kafil, Hossein Samadi, Sakakushev, Boris, Reis, Tarcisio, Pupelis, Guntars, Ponce-de-Leon, Alfredo, Pintar, Tadeja, Picetti, Edoardo, Paolillo, Ciro, Ouadii, Mouaqit, Ordonez, Carlos A., Olaoye, Iyiade, Ofori-Asenso, Richard, Negoi, Ionut, Naidoo, Noel, Moore, Frederick A., Moore, Ernest E., Mesina, Cristian, Memish, Ziad A., McFarlane, Michael, Marwah, Sanjay, Major, Piotr, Manzano-Nunez, Ramiro, Machain, Gustavo M., Litvin, Andrey, Lee, Jae G., Latifi, Rifat, Labricciosa, Francesco M., Isik, Arda, Kok, Kenneth Y. Y., Koike, Kaoru, Khokha, Vladimir, Khamis, Faryal, Kenig, Jakub, Karamarkovic, Aleksandar, Kanj, Souha S., Gomes, Carlos A., Ghnnam, Wagih, Frattima, Sabrina, Fraga, Gustavo P., Ferrada, Paula, Enani, Mushira A., Elmangory, Mutasim M., Dogjani, Agron, Di Saverio, Salomone, Diaz, Jose J., Dhingra, Sameer, Davies, R. Justin, Cui, Yunfeng, de Souza, Hamilton P., De Simone, Belinda, Demetrashvili, Zaza, Jusoh, Asri Che, Beltran, Marcelo A., Baraket, Oussema, Bala, Miklosh, Baiocchi, Gian L., Augustin, Goran, Adesunkanmi, Abdulrashid K., Abu-Zidan, Fikri M., Coccolini, Federico, Giamarellou, Eleni, Bassetti, Matteo, Watkins, Richard R., Rello, Jordi, Hardcastle, Timothy C., Ansaloni, Luca, Kluger, Yoram, and Sartelli, Massimo

Abstract

The Global Alliance for Infections in Surgery appreciates the great effort of the task force who derived and validated the Sepsis-3 definitions and considers the new definitions an important step forward in the evolution of our understanding of sepsis. Nevertheless, more than a year after their publication, we have a few concerns regarding the use of the Sepsis-3 definitions.

Published
2018

49. Performance of computed tomography versus chest radiography in patients with pulmonary tuberculosis with and without diabetes at a tertiary hospital in Riyadh, Saudi Arabia

Author

Alkabab,Yosra, Enani,Mushira, Indarkiri,Nouf, Heysell,Scott, Alkabab,Yosra, Enani,Mushira, Indarkiri,Nouf, and Heysell,Scott

Abstract

Yosra M Alkabab,1 Mushira A Enani,2 Nouf Y Indarkiri,3 Scott K Heysell1 1Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA; 2Department of Infectious Diseases, King Fahad Medical City, 3Department of Family Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia Background: Prior research suggests that diabetes mellitus (DM) is associated with increasing risk for developing cavitary lung disease in patients with pulmonary tuberculosis (TB). Additionally, chest computed tomography (CT) scan may be more sensitive than chest X-ray in detecting cavitary disease in such patients. The aim of this study was to compare the performance of chest CT to chest X-ray in detecting cavitary lung disease and to compare the frequency of cavities between TB patients with DM and without DM.Patients and methods: We conducted a retrospective cohort study at King Fahad Medical City, Riyadh, Saudi Arabia, from January 2004 to December 2015. We included patients aged 18 years and older with a positive sputum culture for Mycobacterium tuberculosis, and their medical charts were reviewed from admission to discharge.Results: Of the 133 patients who met the inclusion criteria, 38 (28.6%) patients were known to have DM and were compared with 95 (71.4%) patients without DM. DM patients with glycated hemoglobin (HbA1c) >6.5% had significantly more cavitary lesions when compared to all patients (with or without DM) with HbA1c <6.4% and/or random blood sugar <200 mg/dL. Furthermore, CT was able to detect lung cavities in 58.8% of the patients who had negative chest X-ray findings for cavities.Conclusion: The presence of lung cavities was significantly associated with the presence of DM and levels of HbA1c in patients with pulmonary TB. CT scan in those with normal radiography increased the detection of cavities. Keywords: diabetes, pulmonary tuberculosis, lung cavities

Published
2018

50. Antimicrobial consumption and resistance in adult hospital inpatients in 53 countries: results of an internet-based global point prevalence survey

Author

Versporten, Ann, primary, Zarb, Peter, additional, Caniaux, Isabelle, additional, Gros, Marie-Françoise, additional, Drapier, Nico, additional, Miller, Mark, additional, Jarlier, Vincent, additional, Nathwani, Dilip, additional, Goossens, Herman, additional, Koraqi, Andi, additional, Hoxha, Iris, additional, Tafaj, Silva, additional, Lacej, Denada, additional, Hojman, Martin, additional, Quiros, Rodolfo Ernesto, additional, Ghazaryan, Lilit, additional, Cairns, Kelly A, additional, Cheng, Allen, additional, Horne, Kylie C, additional, Doukas, Fiona F, additional, Gottlieb, Thomas, additional, Alsalman, Jameela, additional, Magerman, Koen, additional, Marielle, Gounongbe YT, additional, Ljubovic, Amela Dedeic, additional, Coelho, André Afonso Machado, additional, Gales, Ana Cristina, additional, Keuleyan, Emma, additional, Sabuda, Deana, additional, Boswell, Jennifer Lee, additional, Conly, John M, additional, Rojas, Alvaro, additional, Carvajal, Camila, additional, Labarca, Jaime, additional, Solano, Antonio, additional, Valverde, Carlos Ramírez, additional, Villalobos-Vindas, Juan M, additional, Pristas, Irina, additional, Plecko, Vanda, additional, Paphitou, Niki, additional, Shaqiri, Erjona, additional, Rummukainen, Maija-Liisa, additional, Pagava, Karaman, additional, Korinteli, Irma, additional, Brandt, Tobias, additional, Messler, Sabine, additional, Enimil, Anthony, additional, Iosifidis, Elias, additional, Roilides, Emmanuel, additional, Sow, Mamadou Saliou, additional, Sengupta, Sharmila, additional, George, Joby V, additional, Poojary, Aruna, additional, Patil, Priyanka, additional, Soltani, Jafar, additional, Jafarpour, Zahra, additional, Ameen, Hadi, additional, Fitzgerald, David, additional, Maor, Yasmin, additional, Chowers, Michal, additional, Temkin, Elizabeth, additional, Esposito, Susanna, additional, Arnoldo, Luca, additional, Brusaferro, Silvio, additional, Gu, Yoshiaki, additional, El-Hajji, Feras Darwish, additional, Kim, Nam Joong, additional, Kambaralieva, Baktygul, additional, Pavare, Jana, additional, Zarakauska, Lelde, additional, Usonis, Vytautas, additional, Burokiene, Sigita, additional, Ivaskeviciene, Inga, additional, Mijovic, Gordana, additional, Duborija-Kovacevic, Natasa, additional, Bondesio, Kristen, additional, Iregbu, Kenneth, additional, Oduyebo, Oyinlola, additional, Raka, Denis, additional, Raka, Lul, additional, Rachina, Svetlana, additional, Enani, Mushira Abdulaziz, additional, Al Shehri, Mohamed, additional, Carevic, Biljana, additional, Dragovac, Gorana, additional, Obradovic, Dusanka, additional, Stojadinovic, Aleksandra, additional, Radulovic, Lili, additional, Wu, Jia EN, additional, Wei Teng Chung, Gladys, additional, Chen, Hui Hiong, additional, Tambyah, Paul Anantharajah, additional, Lye, David, additional, Tan, Sock Hoon, additional, Ng, Tat Ming, additional, Tay, Hui Lin, additional, Ling, Moi Lin, additional, Chlebicki, Maciej Piotr, additional, Kwa, Andrea L, additional, Lee, Winnie, additional, Beović, Bojana, additional, Dramowski, Angela, additional, Finlayson, Heather, additional, Taljaard, Jantjie, additional, Ojeda-Burgos, Guillermo, additional, Retamar, Pilar, additional, Lucas, Johan, additional, Pot, Wolter, additional, Verduin, Cees, additional, Kluytmans, Jan, additional, Scott, Michael, additional, Aldeyab, Mamoon A, additional, McCullagh, Bernadette, additional, Gormley, Cairine, additional, Sharpe, David, additional, Gilchrist, Mark, additional, Whitney, Laura, additional, Laundy, Matthew, additional, Lockwood, Debbie, additional, Drysdale, Simon B, additional, Boudreaux, Jennifer, additional, Septimus, Edward J, additional, Greer, Nickie, additional, Gawrys, Gerard, additional, Rios, Edgar, additional, and May, Suzanne, additional

Published
2018
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