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1. Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study

Author

Fendler, Annika, Shepherd, Scott T. C., Au, Lewis, Wilkinson, Katalin A., Wu, Mary, Byrne, Fiona, Cerrone, Maddalena, Schmitt, Andreas M., Joharatnam-Hogan, Nalinie, Shum, Benjamin, Tippu, Zayd, Rzeniewicz, Karolina, Boos, Laura Amanda, Harvey, Ruth, Carlyle, Eleanor, Edmonds, Kim, Del Rosario, Lyra, Sarker, Sarah, Lingard, Karla, Mangwende, Mary, Holt, Lucy, Ahmod, Hamid, Korteweg, Justine, Foley, Tara, Bazin, Jessica, Gordon, William, Barber, Taja, Emslie-Henry, Andrea, Xie, Wenyi, Gerard, Camille L., Deng, Daqi, Wall, Emma C., Agua-Doce, Ana, Namjou, Sina, Caidan, Simon, Gavrielides, Mike, MacRae, James I., Kelly, Gavin, Peat, Kema, Kelly, Denise, Murra, Aida, Kelly, Kayleigh, O’Flaherty, Molly, Dowdie, Lauren, Ash, Natalie, Gronthoud, Firza, Shea, Robyn L., Gardner, Gail, Murray, Darren, Kinnaird, Fiona, Cui, Wanyuan, Pascual, Javier, Rodney, Simon, Mencel, Justin, Curtis, Olivia, Stephenson, Clemency, Robinson, Anna, Oza, Bhavna, Farag, Sheima, Leslie, Isla, Rogiers, Aljosja, Iyengar, Sunil, Ethell, Mark, Messiou, Christina, Cunningham, David, Chau, Ian, Starling, Naureen, Turner, Nicholas, Welsh, Liam, van As, Nicholas, Jones, Robin L., Droney, Joanne, Banerjee, Susana, Tatham, Kate C., O’Brien, Mary, Harrington, Kevin, Bhide, Shreerang, Okines, Alicia, Reid, Alison, Young, Kate, Furness, Andrew J. S., Pickering, Lisa, Swanton, Charles, Gandhi, Sonia, Gamblin, Steve, Bauer, David L. V., Kassiotis, George, Kumar, Sacheen, Yousaf, Nadia, Jhanji, Shaman, Nicholson, Emma, Howell, Michael, Walker, Susanna, Wilkinson, Robert J., Larkin, James, and Turajlic, Samra

Published
2021
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2. Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer

Author

Mary Y. Wu, Scott T.C. Shepherd, Annika Fendler, Edward J. Carr, Lewis Au, Ruth Harvey, Giulia Dowgier, Agnieszka Hobbs, Lou S. Herman, Martina Ragno, Lorin Adams, Andreas M. Schmitt, Zayd Tippu, Benjamin Shum, Sheima Farag, Aljosja Rogiers, Nicola O’Reilly, Philip Bawumia, Callie Smith, Eleanor Carlyle, Kim Edmonds, Lyra Del Rosario, Karla Lingard, Mary Mangwende, Lucy Holt, Hamid Ahmod, Justine Korteweg, Tara Foley, Taja Barber, Stephanie Hepworth, Andrea Emslie-Henry, Niamh Caulfield-Lynch, Fiona Byrne, Daqi Deng, Bryan Williams, Michael Brown, Simon Caidan, Mike Gavrielides, James I. MacRae, Gavin Kelly, Kema Peat, Denise Kelly, Aida Murra, Kayleigh Kelly, Molly O’Flaherty, Sanjay Popat, Nadia Yousaf, Shaman Jhanji, Kate Tatham, David Cunningham, Nicholas Van As, Kate Young, Andrew J.S. Furness, Lisa Pickering, Rupert Beale, Charles Swanton, Sonia Gandhi, Steve Gamblin, David L.V. Bauer, George Kassiotis, Michael Howell, Susanna Walker, Emma Nicholson, James Larkin, Emma C. Wall, and Samra Turajlic

Subjects
Cancer Research, Oncology
Published
2023
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3. Stand up comedy and the multi-dimensional character of performance

Author

Emslie-Henry, Rachel A.

Subjects
301, Sociology
Abstract

This thesis examines the multi-dimensional nature of talk surrounding the social phenomenon of performing. Informed by the conversational interview discussions of those closely involved with stand up comedy, the five primary discursive dimensions are considered. These dimensions have been labelled 'Art and Occupation', 'Self and Persona', 'Spontaneous and Rehearsed', 'Talent and Effort', and 'Truth and Believability'. Collectively these dimensions contribute to our understanding of performing, although this understanding is not exclusive to the performers and performance of the stand up comedy environment. The concerns of the particular participants are not necessarily regarded as fundamentally different from our own as we exist as performers in the performance of our own lives. The five dimensions are not only similar in that they each contribute to our understanding of performers and performance, they are also similarly dyadic in nature, being constructed around the juxtaposition of two ostensibly oppositional concepts, as suggested by the labels given to them. Though participants do not necessarily treat all of them as straightforwardly oppositional, each dimension displays a certain tension between the poles. The theoretical conception informing this work has developed in two ways: ethnographically, as the result of working with interview data, and through a close analysis of other pre-existing theoretical conceptions around the issues of knowledge, ideology and discourse. Specifically, five theoretical approaches are considered: Mannheimian sociology of knowledge; Foucauldian discourses; social representation theory; interpretative repertoires; and ideological dilemmas. It was found that these approaches divide (roughly) into group consensus theories and dilemmatic theories. The latter group was found to be more pertinent for the analysis of the material here. Nevertheless, neither dilemmatic theory alone, nor a simple combination of the two, did justice to the specifics under consideration. Thus, this thesis remains eclectic in terms of its theoretical underpinnings. The tensions and oppositions that are evident in the talk around stand up comedy are clear indications of equivalent tensions inherent in performance, and the practice of performers, more generally. Indeed, it would appear that performing of all kinds is intrinsically paradoxical. Thus the results presented here have resonance and relevance beyond the world of stand up comedy alone.

Published
2000

4. Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer

Author

Wu, Mary Y., primary, Shepherd, Scott T.C., additional, Fendler, Annika, additional, Carr, Edward J., additional, Au, Lewis, additional, Harvey, Ruth, additional, Dowgier, Giulia, additional, Hobbs, Agnieszka, additional, Herman, Lou S., additional, Ragno, Martina, additional, Adams, Lorin, additional, Schmitt, Andreas M., additional, Tippu, Zayd, additional, Shum, Benjamin, additional, Farag, Sheima, additional, Rogiers, Aljosja, additional, O’Reilly, Nicola, additional, Bawumia, Philip, additional, Smith, Callie, additional, Carlyle, Eleanor, additional, Edmonds, Kim, additional, Del Rosario, Lyra, additional, Lingard, Karla, additional, Mangwende, Mary, additional, Holt, Lucy, additional, Ahmod, Hamid, additional, Korteweg, Justine, additional, Foley, Tara, additional, Barber, Taja, additional, Hepworth, Stephanie, additional, Emslie-Henry, Andrea, additional, Caulfield-Lynch, Niamh, additional, Byrne, Fiona, additional, Deng, Daqi, additional, Williams, Bryan, additional, Brown, Michael, additional, Caidan, Simon, additional, Gavrielides, Mike, additional, MacRae, James I., additional, Kelly, Gavin, additional, Peat, Kema, additional, Kelly, Denise, additional, Murra, Aida, additional, Kelly, Kayleigh, additional, O’Flaherty, Molly, additional, Popat, Sanjay, additional, Yousaf, Nadia, additional, Jhanji, Shaman, additional, Tatham, Kate, additional, Cunningham, David, additional, Van As, Nicholas, additional, Young, Kate, additional, Furness, Andrew J.S., additional, Pickering, Lisa, additional, Beale, Rupert, additional, Swanton, Charles, additional, Gandhi, Sonia, additional, Gamblin, Steve, additional, Bauer, David L.V., additional, Kassiotis, George, additional, Howell, Michael, additional, Walker, Susanna, additional, Nicholson, Emma, additional, Larkin, James, additional, Wall, Emma C., additional, and Turajlic, Samra, additional

Published
2023
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5. Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer

Author

Fendler, Annika, primary, Shepherd, Scott T.C., additional, Au, Lewis, additional, Wu, Mary, additional, Harvey, Ruth, additional, Wilkinson, Katalin A., additional, Schmitt, Andreas M., additional, Tippu, Zayd, additional, Shum, Benjamin, additional, Farag, Sheima, additional, Rogiers, Aljosja, additional, Carlyle, Eleanor, additional, Edmonds, Kim, additional, Del Rosario, Lyra, additional, Lingard, Karla, additional, Mangwende, Mary, additional, Holt, Lucy, additional, Ahmod, Hamid, additional, Korteweg, Justine, additional, Foley, Tara, additional, Barber, Taja, additional, Emslie-Henry, Andrea, additional, Caulfield-Lynch, Niamh, additional, Byrne, Fiona, additional, Deng, Daqi, additional, Kjaer, Svend, additional, Song, Ok-Ryul, additional, Queval, Christophe J., additional, Kavanagh, Caitlin, additional, Wall, Emma C., additional, Carr, Edward J., additional, Caidan, Simon, additional, Gavrielides, Mike, additional, MacRae, James I., additional, Kelly, Gavin, additional, Peat, Kema, additional, Kelly, Denise, additional, Murra, Aida, additional, Kelly, Kayleigh, additional, O’Flaherty, Molly, additional, Shea, Robyn L., additional, Gardner, Gail, additional, Murray, Darren, additional, Popat, Sanjay, additional, Yousaf, Nadia, additional, Jhanji, Shaman, additional, Tatham, Kate, additional, Cunningham, David, additional, Van As, Nicholas, additional, Young, Kate, additional, Furness, Andrew J.S., additional, Pickering, Lisa, additional, Beale, Rupert, additional, Swanton, Charles, additional, Gandhi, Sonia, additional, Gamblin, Steve, additional, Bauer, David L.V., additional, Kassiotis, George, additional, Howell, Michael, additional, Nicholson, Emma, additional, Walker, Susanna, additional, Wilkinson, Robert J., additional, Larkin, James, additional, and Turajlic, Samra, additional

Published
2022
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6. Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer

Author

Fendler, Annika, Shepherd, Scott T C, Au, Lewis, Wu, Mary, Harvey, Ruth, Schmitt, Andreas M, Tippu, Zayd, Shum, Benjamin, Farag, Sheima, Rogiers, Aljosja, Carlyle, Eleanor, Edmonds, Kim, Del Rosario, Lyra, Lingard, Karla, Mangwende, Mary, Holt, Lucy, Ahmod, Hamid, Korteweg, Justine, Foley, Tara, Barber, Taja, Emslie-Henry, Andrea, Caulfield-Lynch, Niamh, Byrne, Fiona, Deng, Daqi, Kjaer, Svend, Song, Ok-Ryul, Queval, Christophe, Kavanagh, Caitlin, Wall, Emma C, Carr, Edward J, Caidan, Simon, Gavrielides, Mike, MacRae, James I, Kelly, Gavin, Peat, Kema, Kelly, Denise, Murra, Aida, Kelly, Kayleigh, O'Flaherty, Molly, Shea, Robyn L, Gardner, Gail, Murray, Darren, Yousaf, Nadia, Jhanji, Shaman, Tatham, Kate, Cunningham, David, Van As, Nicholas, Young, Kate, Furness, Andrew J S, Pickering, Lisa, Beale, Rupert, Swanton, Charles, Gandhi, Sonia, Gamblin, Steve, Bauer, David L V, Kassiotis, George, Howell, Michael, Nicholson, Emma, Walker, Susanna, Larkin, James, and Turajlic, Samra

Published
2022
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7. Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer

Author

Fendler, Annika, Shepherd, Scott T.C., Au, Lewis, Wilkinson, Katalin A., Wu, Mary, Schmitt, Andreas M., Tippu, Zayd, Farag, Sheima, Rogiers, Aljosja, Harvey, Ruth, Carlyle, Eleanor, Edmonds, Kim, Del Rosario, Lyra, Lingard, Karla, Mangwende, Mary, Holt, Lucy, Ahmod, Hamid, Korteweg, Justine, Foley, Tara, Barber, Taja, Emslie-Henry, Andrea, Caulfield-Lynch, Niamh, Byrne, Fiona, Shum, Benjamin, Gerard, Camille L., Deng, Daqi, Kjaer, Svend, Song, Ok-Ryul, Queval, Christophe, Kavanagh, Caitlin, Wall, Emma C., Carr, Edward J., Namjou, Sina, Caidan, Simon, Gavrielides, Mike, MacRae, James I., Kelly, Gavin, Peat, Kema, Kelly, Denise, Murra, Aida, Kelly, Kayleigh, O’Flaherty, Molly, Shea, Robyn L., Gardner, Gail, Murray, Darren, Popat, Sanjay, Yousaf, Nadia, Jhanji, Shaman, Van As, Nicholas, Young, Kate, Furness, Andrew J.S., Pickering, Lisa, Beale, Rupert, Swanton, Charles, Gandhi, Sonia, Gamblin, Steve, Bauer, David L.V., Kassiotis, George, Howell, Michael, Nicholson, Emma, Walker, Susanna, Wilkinson, Robert J., Larkin, James, and Turajlic, Samra

Published
2022
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8. Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study

Author

Fendler, Annika, Shepherd, Scott TC, Au, Lewis, Wilkinson, Katalin A, Wu, Mary, Byrne, Fiona, Cerrone, Maddalena, Schmitt, Andreas M, Joharatnam-Hogan, Nalinie, Shum, Benjamin, Tippu, Zayd, Rzeniewicz, Karolina, Boos, Laura Amanda, Harvey, Ruth, Carlyle, Eleanor, Edmonds, Kim, Del Rosario, Lyra, Sarker, Sarah, Lingard, Karla, Mangwende, Mary, Holt, Lucy, Ahmod, Hamid, Korteweg, Justine, Foley, Tara, Bazin, Jessica, Gordon, William, Barber, Taja, Emslie-Henry, Andrea, Xie, Wenyi, Gerard, Camille L, Deng, Daqi, Wall, Emma C, Agua-Doce, Ana, Namjou, Sina, Caidan, Simon, Gavrielides, Mike, MacRae, James I, Kelly, Gavin, Peat, Kema, Kelly, Denise, Murra, Aida, Kelly, Kayleigh, O���Flaherty, Molly, Dowdie, Lauren, Ash, Natalie, Gronthoud, Firza, Shea, Robyn L, Gardner, Gail, Murray, Darren, Kinnaird, Fiona, Cui, Wanyuan, Pascual, Javier, Rodney, Simon, Mencel, Justin, Curtis, Olivia, Stephenson, Clemency, Robinson, Anna, Oza, Bhavna, Farag, Sheima, Leslie, Isla, Rogiers, Aljosja, Iyengar, Sunil, Ethell, Mark, Messiou, Christina, Cunningham, David, Chau, Ian, Starling, Naureen, Turner, Nicholas, Welsh, Liam, van As, Nicholas, Jones, Robin L, Droney, Joanne, Banerjee, Susana, Tatham, Kate C, O���Brien, Mary, Harrington, Kevin, Bhide, Shreerang, Okines, Alicia, Reid, Alison, Young, Kate, Furness, Andrew JS, Pickering, Lisa, Swanton, Charles, Consortium, The Crick COVID-19, Gandhi, Sonia, Gamblin, Steve, Bauer, David LV, Kassiotis, George, Kumar, Sacheen, Yousaf, Nadia, Jhanji, Shaman, Nicholson, Emma, Howell, Michael, Walker, Susanna, Wilkinson, Robert J, Larkin, James, Turajlic, Samra, and Consortium, The CAPTURE

Subjects
Model organisms, Chemical Biology & High Throughput, Human Biology & Physiology, FOS: Clinical medicine, Stem Cells, Genome Integrity & Repair, Immunology, Neurosciences, Infectious Disease, Cell Biology, Tumour Biology, Biochemistry & Proteomics, Signalling & Oncogenes, Metabolism, Ecology,Evolution & Ethology, Cell Cycle & Chromosomes, Genetics & Genomics, Developmental Biology, Structural Biology & Biophysics, Computational & Systems Biology
Abstract

Coronavirus disease 2019 (COVID-19) antiviral response in a pan-tumor immune monitoring (CAPTURE) (NCT03226886) is a prospective cohort study of COVID-19 immunity in patients with cancer. Here we evaluated 585 patients following administration of two doses of BNT162b2 or AZD1222 vaccines, administered 12 weeks apart. Seroconversion rates after two doses were 85% and 59% in patients with solid and hematological malignancies, respectively. A lower proportion of patients had detectable titers of neutralizing antibodies (NAbT) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) versus wild-type (WT) SARS-CoV-2. Patients with hematological malignancies were more likely to have undetectable NAbT and had lower median NAbT than those with solid cancers against both SARS-CoV-2 WT and VOC. By comparison with individuals without cancer, patients with hematological, but not solid, malignancies had reduced neutralizing antibody (NAb) responses. Seroconversion showed poor concordance with NAbT against VOC. Previous SARS-CoV-2 infection boosted the NAb response including against VOC, and anti-CD20 treatment was associated with undetectable NAbT. Vaccine-induced T cell responses were detected in 80% of patients and were comparable between vaccines or cancer types. Our results have implications for the management of patients with cancer during the ongoing COVID-19 pandemic.

Published
2022
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9. Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer

Author

Annika Fendler, Scott T.C. Shepherd, Lewis Au, Mary Wu, Ruth Harvey, Katalin A. Wilkinson, Andreas M. Schmitt, Zayd Tippu, Benjamin Shum, Sheima Farag, Aljosja Rogiers, Eleanor Carlyle, Kim Edmonds, Lyra Del Rosario, Karla Lingard, Mary Mangwende, Lucy Holt, Hamid Ahmod, Justine Korteweg, Tara Foley, Taja Barber, Andrea Emslie-Henry, Niamh Caulfield-Lynch, Fiona Byrne, Daqi Deng, Svend Kjaer, Ok-Ryul Song, Christophe J. Queval, Caitlin Kavanagh, Emma C. Wall, Edward J. Carr, Simon Caidan, Mike Gavrielides, James I. MacRae, Gavin Kelly, Kema Peat, Denise Kelly, Aida Murra, Kayleigh Kelly, Molly O’Flaherty, Robyn L. Shea, Gail Gardner, Darren Murray, Sanjay Popat, Nadia Yousaf, Shaman Jhanji, Kate Tatham, David Cunningham, Nicholas Van As, Kate Young, Andrew J.S. Furness, Lisa Pickering, Rupert Beale, Charles Swanton, Sonia Gandhi, Steve Gamblin, David L.V. Bauer, George Kassiotis, Michael Howell, Emma Nicholson, Susanna Walker, Robert J. Wilkinson, James Larkin, and Samra Turajlic

Subjects
Model organisms, COVID-19 Vaccines, Immunology, T cells, Infectious Disease, variants of concern, Antibodies, Viral, Biochemistry & Proteomics, General Biochemistry, Genetics and Molecular Biology, Signalling & Oncogenes, Ecology,Evolution & Ethology, Neoplasms, Humans, neutralizing antibodies, BNT162 Vaccine, Computational & Systems Biology, Chemical Biology & High Throughput, Human Biology & Physiology, SARS-CoV-2, blood cancer, FOS: Clinical medicine, Stem Cells, Clinical Studies as Topic, Genome Integrity & Repair, Immunity, Neurosciences, COVID-19, Cell Biology, Tumour Biology, Antibodies, Neutralizing, Metabolism, Cell Cycle & Chromosomes, Genetics & Genomics, Developmental Biology, Structural Biology & Biophysics
Abstract

Patients with blood cancer continue to have a greater risk of inadequate immune responses following three COVID-19 vaccine doses and risk of severe COVID-19 disease. In the context of the CAPTURE study (NCT03226886), we report immune responses in 80 patients with blood cancer who received a fourth dose of BNT162b2. We measured neutralizing antibody titers (NAbTs) using a live virus microneutralization assay against wild-type (WT), Delta, and Omicron BA.1 and BA.2 and T cell responses against WT and Omicron BA.1 using an activation-induced marker (AIM) assay. The proportion of patients with detectable NAb titers and T cell responses after the fourth vaccine dose increased compared with that after the third vaccine dose. Patients who received B cell-depleting therapies within the 12 months before vaccination have the greatest risk of not having detectable NAbT. In addition, we report immune responses in 57 patients with breakthrough infections after vaccination.

Published
2022
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10. Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer

Author

Annika Fendler, Scott T C Shepherd, Lewis Au, Mary Wu, Ruth Harvey, Andreas M Schmitt, Zayd Tippu, Benjamin Shum, Sheima Farag, Aljosja Rogiers, Eleanor Carlyle, Kim Edmonds, Lyra Del Rosario, Karla Lingard, Mary Mangwende, Lucy Holt, Hamid Ahmod, Justine Korteweg, Tara Foley, Taja Barber, Andrea Emslie-Henry, Niamh Caulfield-Lynch, Fiona Byrne, Daqi Deng, Svend Kjaer, Ok-Ryul Song, Christophe Queval, Caitlin Kavanagh, Emma C Wall, Edward J Carr, Simon Caidan, Mike Gavrielides, James I MacRae, Gavin Kelly, Kema Peat, Denise Kelly, Aida Murra, Kayleigh Kelly, Molly O'Flaherty, Robyn L Shea, Gail Gardner, Darren Murray, Nadia Yousaf, Shaman Jhanji, Kate Tatham, David Cunningham, Nicholas Van As, Kate Young, Andrew J S Furness, Lisa Pickering, Rupert Beale, Charles Swanton, Sonia Gandhi, Steve Gamblin, David L V Bauer, George Kassiotis, Michael Howell, Emma Nicholson, Susanna Walker, James Larkin, and Samra Turajlic

Subjects
COVID-19 Vaccines, Letter, SARS-CoV-2, Neoplasms, Correspondence, COVID-19, Humans, General Medicine, Antibodies, Viral, Antibodies, Neutralizing
Published
2022

11. Immune responses following third COVID-19 vaccination are reduced in patients with hematologic malignancies compared to patients with solid cancer

Author

Annika Fendler, Scott T.C. Shepherd, Lewis Au, Katalin A. Wilkinson, Mary Wu, Andreas M. Schmitt, Zayd Tippu, Sheima Farag, Aljosja Rogiers, Ruth Harvey, Eleanor Carlyle, Kim Edmonds, Lyra Del Rosario, Karla Lingard, Mary Mangwende, Lucy Holt, Hamid Ahmod, Justine Korteweg, Tara Foley, Taja Barber, Andrea Emslie-Henry, Niamh Caulfield-Lynch, Fiona Byrne, Benjamin Shum, Camille L. Gerard, Daqi Deng, Svend Kjaer, Ok-Ryul Song, Christophe Queval, Caitlin Kavanagh, Emma C. Wall, Edward J. Carr, Sina Namjou, Simon Caidan, Mike Gavrielidis, James McRae, Gavin Kelly, Kema Peat, Denise Kelly, Aida Murra, Kayleigh Kelly, Molly O'Flaherty, Robyn L. Shea, Gail Gardner, Darren Murray, Nadia Yousaf, Shaman Jhanji, Nicholas Van As, Kate Young, Andre J.S. Furness, Lisa Pickering, Rupert Beale, Charles Swanton, Sonia Ghandi, Steve Gamblin, David L.V. Bauer, George Kassiotis, Michael Howell, Emma Nicholson, Robert J. Wilkinson, James Larkin, and Samra Turajlic

Abstract

Not all patients with cancer, in particular those with hematogic malignancies, develop functional immunity against SARS-CoV-2 variants of concern (VOC) following COVID-19 vaccines. Durability of vaccine-induced immunity after two doses and the impact of a third dose were evaluated in CAPTURE (NCT03226886), a longitudinal prospective cohort study of vaccine responses in patients with cancer. In evaluating 316 patients, at a median of 111 days following two doses of either BNT16b2 or ChadOX, we observed a time-dependant decline in neutralising antibody titres (NAbT) in a proportion of patients, where NAbTs became undetectable against Delta and Beta in 17% and 15% of patients, respectively. Vaccine-induced T cell responses declined in 44% of patients. Patients with breakthrough infections following two vaccines doses were characterised by absent/low NAbT to Delta prior to infection. Administration of the third vaccine dose boosted NAb responses against VOC in the majority of patients with cancer, especially those with solid cancer. In patients with hematologic malignancies who had undetectable NAbT against Delta after two vaccine doses, 54% did not develop NAb against both Beta and Delta following the third dose. Third vaccine dose boosted T cell responses were boosted in patients with both solid and hematologic malignancies. These results provide critical information on vaccine responses in patients with cancer, especially against VOCs and support widespread access to a third COVID-19 vaccination in this patient group.

Published
2021
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12. Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: The CAPTURE study

Author

Lisa Pickering, Nalinie Joharatnam-Hogan, Fiona Kinnaird, Andrew Furness, Mary Wu, Daqi Deng, Sina Namjou, Sarah Sarker, Aljosja Rogiers, Aida Murra, Justine Korteweg, Nicholas van As, Nicholas C. Turner, Anna Robinson, Joanne Droney, Kema Peat, Shaman Jhanji, Mike Gavrielides, Isla Leslie, Lauren Dowdie, Tara Foley, Christina Messiou, Natalie Ash, Taja Barber, Andrea Emslie-Henry, Simon Caidan, Karolina Rzeniewicz, Katalin A. Wilkinson, Ruth Harvey, Annika Fendler, Kate Tatham, Andreas M. Schmitt, Sunil Iyengar, Shreerang Bhide, Kayleigh Kelly, David L.V. Bauer, Benjamin Shum, Kim Edmonds, Gail Gardner, Scott Shepherd, Mark Ethell, Laura Amanda Boos, Liam Welsh, Robert J. Wilkinson, Lucy Holt, Alicia Okines, William Gordon, James I. MacRae, Maddalena Cerrone, Kevin J. Harrington, Mary Mangwende, Hamid Ahmod, Olivia Curtis, Emma Nicholson, Darren Murray, Susana Banerjee, Firza Gronthoud, Bhavna Oza, Naureen Starling, Wenyi Xie, Alison Reid, Karla Lingard, Ana Agua-Doce, Charles Swanton, Sacheen Kumar, Lewis Au, Michael Howell, James Larkin, Camille L. Gerard, Emma C Wall, Jessica Bazin, Ian Chau, Robin L. Jones, Fiona Byrne, Robyn L. Shea, Denise Kelly, Nadia Yousaf, Steve Gamblin, Kate Young, Sonia Gandhi, Susanna Walker, Eleanor Carlyle, Javier Pascual, David Cunningham, Samra Turajlic, Clemency Stephenson, Zayd Tippu, Gavin Kelly, Mary O'Brien, Sheima Farag, Molly O’Flaherty, George Kassiotis, Wanyuan Cui, Justin Mencel, Lyra Del Rosario, Simon Rodney, and Wellcome Trust

Subjects
Male, Cancer Research, T-Lymphocytes, Antibody Response, Adaptive Immunity, IMMUNOGENICITY, Antibodies, Viral, COVID-19 VACCINATION, Immunogenicity, Vaccine, Neoplasms, Longitudinal Studies, Prospective Studies, Neutralizing antibody, Prospective cohort study, Cancer, Aged, 80 and over, Immunity, Cellular, biology, Vaccination, Middle Aged, Acquired immune system, Kidney Neoplasms, Oncology, Female, Antibody, Life Sciences & Biomedicine, Neutralising Antibodies, T-cell Response, Adult, COVID-19 Vaccines, Article, MALIGNANCIES, Crick COVID19 consortium, Immunity, VACCINES, ChAdOx1 nCoV-19, medicine, Humans, Seroconversion, Carcinoma, Renal Cell, Pandemics, BNT162 Vaccine, Aged, Science & Technology, business.industry, SARS-CoV-2, MORTALITY, COVID-19, medicine.disease, Antibodies, Neutralizing, DEMOGRAPHICS, Immunology, biology.protein, Prospective Study, business, Vaccine
Abstract

Coronavirus disease 2019 (COVID-19) antiviral response in a pan-tumor immune monitoring (CAPTURE) (NCT03226886) is a prospective cohort study of COVID-19 immunity in patients with cancer. Here we evaluated 585 patients following administration of two doses of BNT162b2 or AZD1222 vaccines, administered 12 weeks apart. Seroconversion rates after two doses were 85% and 59% in patients with solid and hematological malignancies, respectively. A lower proportion of patients had detectable titers of neutralizing antibodies (NAbT) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) versus wild-type (WT) SARS-CoV-2. Patients with hematological malignancies were more likely to have undetectable NAbT and had lower median NAbT than those with solid cancers against both SARS-CoV-2 WT and VOC. By comparison with individuals without cancer, patients with hematological, but not solid, malignancies had reduced neutralizing antibody (NAb) responses. Seroconversion showed poor concordance with NAbT against VOC. Previous SARS-CoV-2 infection boosted the NAb response including against VOC, and anti-CD20 treatment was associated with undetectable NAbT. Vaccine-induced T cell responses were detected in 80% of patients and were comparable between vaccines or cancer types. Our results have implications for the management of patients with cancer during the ongoing COVID-19 pandemic.

Published
2021
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13. Immune responses following third COVID-19 vaccination are reduced in patients with hematologic malignancies compared to patients with solid cancer

Author

Fendler, Annika, primary, Shepherd, Scott T.C., additional, Au, Lewis, additional, Wilkinson, Katalin A., additional, Wu, Mary, additional, Schmitt, Andreas M., additional, Tippu, Zayd, additional, Farag, Sheima, additional, Rogiers, Aljosja, additional, Harvey, Ruth, additional, Carlyle, Eleanor, additional, Edmonds, Kim, additional, Rosario, Lyra Del, additional, Lingard, Karla, additional, Mangwende, Mary, additional, Holt, Lucy, additional, Ahmod, Hamid, additional, Korteweg, Justine, additional, Foley, Tara, additional, Barber, Taja, additional, Emslie-Henry, Andrea, additional, Caulfield-Lynch, Niamh, additional, Byrne, Fiona, additional, Shum, Benjamin, additional, Gerard, Camille L., additional, Deng, Daqi, additional, Kjaer, Svend, additional, Song, Ok-Ryul, additional, Queval, Christophe, additional, Kavanagh, Caitlin, additional, Wall, Emma C., additional, Carr, Edward J., additional, Namjou, Sina, additional, Caidan, Simon, additional, Gavrielidis, Mike, additional, McRae, James, additional, Kelly, Gavin, additional, Peat, Kema, additional, Kelly, Denise, additional, Murra, Aida, additional, Kelly, Kayleigh, additional, O'Flaherty, Molly, additional, Shea, Robyn L., additional, Gardner, Gail, additional, Murray, Darren, additional, Yousaf, Nadia, additional, Jhanji, Shaman, additional, As, Nicholas Van, additional, Young, Kate, additional, Furness, Andre J.S., additional, Pickering, Lisa, additional, Beale, Rupert, additional, Swanton, Charles, additional, Ghandi, Sonia, additional, Gamblin, Steve, additional, Bauer, David L.V., additional, Kassiotis, George, additional, Howell, Michael, additional, Nicholson, Emma, additional, Wilkinson, Robert J., additional, Larkin, James, additional, and Turajlic, Samra, additional

Published
2021
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14. Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: The CAPTURE study

Author

Fendler, Annika, primary, Shepherd, Scott, additional, Au, Lewis, additional, Wilkinson, Katalin, additional, Wu, Mary, additional, Byrne, Fiona, additional, Cerrone, Maddalena, additional, Schmitt, Andreas, additional, Joharatnam-Hogan, Nalinie, additional, Shum, Ben, additional, Tippu, Zayd, additional, Rzeniewicz, Karolina, additional, Boos, Laura, additional, Harvey, Ruth, additional, Carlyle, Eleanor, additional, Edmonds, Kim, additional, Rosario, Lyra Del, additional, Sarker, Sarah, additional, Lingard, Karla, additional, Mangwende, Mary, additional, Holt, Lucy, additional, Ahmod, Hamid, additional, Koreweg, Justine, additional, Foley, Tara, additional, Bazin, Jessica, additional, Gordon, William, additional, Barber, Taja, additional, Emslie-Henry, Andrea, additional, Xie, Wenyi, additional, Gerard, Camille, additional, Deng, Daqi, additional, Wall, Emma, additional, Agua-Doce, Ana, additional, Namjou, Sina, additional, Caidan, Simon, additional, Gavrielides, Mike, additional, MacRae, James, additional, Kelly, Gavin, additional, Peat, Kema, additional, Kelly, Denise, additional, Murra, Aida, additional, Kelly, Kayleigh, additional, O'Flaherty, Molly, additional, Dowdie, Lauren, additional, Ash, Natalie, additional, Grounthoud, Firza, additional, Shea, Robyn, additional, Gardner, Gail, additional, Murray, Darren, additional, Kinnaird, Fiona, additional, Cui, Wanyuan, additional, Pascual, Javier, additional, Rodney, Simon, additional, Mencel, Justin, additional, Curtis, Olivia, additional, Stephenson, Clemency, additional, Robinson, Anna, additional, Oza, Bhavna, additional, Farag, Sheima, additional, Leslie, Isla, additional, Rogiers, Aljosja, additional, Lyengar, Sunil, additional, Ethell, Mark, additional, Messiou, Christina, additional, Cunningham, David, additional, Chau, Ian, additional, Starling, Naureen, additional, Turner, Nicholas, additional, Welsh, Liam, additional, As, Nicholas van, additional, Jones, Robin, additional, DRoney, Joanne, additional, Banerjee, Susana, additional, Tatham, Kate, additional, O'Brien, Mary, additional, Harrington, Kevin, additional, Bhide, Shreerang, additional, Okines, Alicia, additional, Reid, Alison, additional, Young, Kate, additional, Furness, Andrew, additional, Pickering, Lisa, additional, Swanton, Charles, additional, Gandhi, Sonia, additional, Gamblin, Steve, additional, Bauer, David, additional, Kassiotis, George, additional, Kumar, Sacheen, additional, Yousaf, Nadia, additional, Jhanji, Shaman, additional, Nicholson, Emma, additional, Howell, Michael, additional, Walker, Susanna, additional, Wilkinson, Robert, additional, Larkin, James, additional, and Turajlic, Samra, additional

Published
2021
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