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1. Mental health impact of the first wave of COVID-19 pandemic on Spanish healthcare workers: A large cross-sectional survey

Author

Alonso, Jordi, Vilagut, Gemma, Mortier, Philippe, Ferrer, Montse, Alayo, Itxaso, Aragón-Peña, Andrés, Aragonès, Enric, Campos, Mireia, Cura-González, Isabel D., Emparanza, José I., Espuga, Meritxell, Forjaz, Maria João, González-Pinto, Ana, Haro, Josep M., López-Fresneña, Nieves, Salázar, Alma D. Martínez de, Molina, Juan D., Ortí-Lucas, Rafael M., Parellada, Mara, Pelayo-Terán, José Maria, Pérez-Zapata, Aurora, Pijoan, José I., Plana, Nieves, Puig, Maria Teresa, Rius, Cristina, Rodríguez-Blázquez, Carmen, Sanz, Ferran, Serra, Consol, Kessler, Ronald C., Bruffaerts, Ronny, Vieta, Eduard, and Pérez-Solà, Víctor

Published
2021
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6. Four-month incidence of suicidal thoughts and behaviors among healthcare workers after the first wave of the Spain COVID-19 pandemic

Author

Alonso, Jordi, Alayo, Itxaso, Alonso, Manuel, Álvarez, Mar, Amann, Benedikt, Amigo, Franco F., Anmella, Gerard, Aragón, Andres, Aragonés, Nuria, Aragonès, Enric, Arizón, Ana Isabel, Asunsolo, Angel, Ayora, Alfons, Ballester, Laura, Barbas, Puri, Basora, Josep, Bereciartua, Elena, Ignasi Bolibar, Inés Bravo, Bonfill, Xavier, Cotillas, Alberto, Cuartero, Andres, de Paz, Concha, Cura, Isabel del, Jesus del Yerro, Maria, Diaz, Domingo, Domingo, Jose Luis, Emparanza, Jose I., Espallargues, Mireia, Espuga, Meritxell, Estevan, Patricia, Fernandez, M. Isabel, Fernandez, Tania, Ferrer, Montse, Ferreres, Yolanda, Fico, Giovanna, Forjaz, M. Joao, Barranco, Rosa Garcia, Garcia TorrecillasC Garcia-Ribera, J. Manuel, Garrido, Araceli, Gil, Elisa, Gomez, Marta, Gomez, Javier, Pinto, Ana Gonzalez, Haro, Josep Maria, Hernando, Margarita, Insigna, Maria Giola, Iriberri, Milagros, Jimenez, Nuria, Jimenez, Xavi, Larrauri, Amparo, Leon, Fernando, Lopez-Fresneña, Nieves, Lopez, Carmen, Lopez-Atanes Juan Antonio Lopez-Rodriguez, Mayte, Lopez-Cortacans, German, Marcos, Alba, Martin, Jesus, Martin, Vicente, Martinez-Cortés, Mercedes, Martinez-Martinez, Raquel, Martinez de Salazar, Alma D., Martinez, Isabel, Marzola, Marco, Mata, Nelva, Molina, Josep Maria, de Dios Molina, Juan, Molinero, Emilia, Mortier, Philippe, Muñoz, Carmen, Murru, Andrea, Olmedo, Jorge, Ortí, Rafael M., Padrós, Rafael, Pallejà, Meritxell, Parra, Raul, Pascual, Julio, Pelayo, Jose Maria, Pla, Rosa, Plana, Nieves, Aznar, Coro Perez, Gomez, Beatriz Perez, Zapata, Aurora Perez, Pijoan, Jose Ignacio, Polentinos, Elena, Puertolas, Beatriz, Puig, Maria Teresa, Quílez, Alex, Quintana, M. Jesus, Quiroga, Antonio, Rentero, David, Rey, Cristina, Rius, Cristina, Rodriguez-Blazquez, Carmen, Rojas, M. Jose, Romero, Yamina, Rubio, Gabriel, Rumayor, Mercedes, Ruiz, Pedro, Saenz, Margarita, Sanchez, Jesus, Sanchez-Arcilla, Ignacio, Sanz, Ferran, Serra, Consol, Serra-Sutton, Victoria, Serrano, Manuela, Sola, Silvia, Solera, Sara, Soto, Miguel, Tarrago, Alejandra, Tolosa, Natividad, Vazquez, Mireia, Viciola, Margarita, Vieta, Eduard, Vilagut, Gemma, Yago, Sara, Yañez, Jesus, Zapico, Yolanda, Zorita, Luis Maria, Zorrilla, Iñaki, Zurbano, Saioa L., Perez-Solá, Victor, Mortier, P., Vilagut, G., Alayo, I., Ferrer, M., Amigo, F., Aragonès, E., Aragón-Peña, A., Asúnsolo del Barco, A., Campos, M., Espuga, M., González-Pinto, A., Haro, J.M., López Fresneña, N., Martínez de Salázar, A., Molina, J.D., Ortí-Lucas, R.M., Parellada, M., Pelayo-Terán, J.M., Pérez-Gómez, B., Pérez-Zapata, A., Pijoan, J.I., Plana, N., Polentinos-Castro, E., Portillo-Van Diest, A., Puig, M.T., Rius, C., Sanz, F., Serra, C., Urreta-Barallobre, I., Kessler, R.C., Bruffaerts, R., Vieta, E., Pérez-Solá, V., and Alonso, J.

Published
2022
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9. Thirty-day suicidal thoughts and behaviors among hospital workers during the first wave of the Spain COVID-19 outbreak

Author

Mortier, Philippe, Vilagut, Gemma, Ferrer, Montse, Serra, Consol, Molina, Juan D, López-Fresneña, Nieves, Puig, Teresa, Pelayo-Terán, José M, Pijoan, José I, Emparanza, José I, Espuga, Meritxell, Plana, Nieves, González-Pinto, Ana, Ortí-Lucas, Rafael M, de Salázar, Alma M, Rius, Cristina, Aragonès, Enric, Del Cura-González, Isabel, Aragón-Peña, Andrés, Campos, Mireia, Parellada, Mara, Pérez-Zapata, Aurora, Forjaz, Maria João, Sanz, Ferran, Haro, Josep M, Vieta, Eduard, Pérez-Solà, Víctor, Kessler, Ronald C, Bruffaerts, Ronny, Alonso, Jordi, MINDCOVID Working group, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Government of Catalonia (España), European Regional Development Fund, and Ministerio de Universidades (España)

Subjects
suicidal thoughts and behaviors, Psychology, Clinical, Social Sciences, Suicide, Attempted, Disease Outbreaks, PHYSICIANS, 0302 clinical medicine, Risk Factors, Health care, Prevalence, Psychology, Suicidal thoughts and behaviors, Research Articles, Psychiatry, Hospitals, Psychiatry and Mental health, Clinical Psychology, COVID‐19 outbreak, COVID-19 outbreak, hospital workers, Preparedness, Cohort, Life Sciences & Biomedicine, Anxiety disorder, Research Article, EUROPE, Coronavirus disease 2019 (COVID-19), Hospital workers, Suicidal Ideation, 03 medical and health sciences, COVID‐19, medicine, Humans, IDEATION, Students, METAANALYSIS, Science & Technology, business.industry, SARS-CoV-2, Outbreak, COVID-19, Odds ratio, NATIONWIDE, medicine.disease, 030227 psychiatry, Mood, Spain, RISK-FACTORS, business, 030217 neurology & neurosurgery, Demography
Abstract

Background: Healthcare workers are a key occupational group at risk for suicidal thoughts and behaviors (STB). We investigated the prevalence and correlates of STB among hospital workers during the first wave of the Spain COVID-19 outbreak (March-July 2020). Methods: Data come from the baseline assessment of a cohort of Spanish hospital workers (n = 5450), recruited from 10 hospitals just after the height of the coronavirus disease 2019 (COVID-19) outbreak (May 5-July 23, 2020). Web-based self-report surveys assessed 30-day STB, individual characteristics, and potentially modifiable contextual factors related to hospital workers' work and financial situation. Results: Thirty-day STB prevalence was estimated at 8.4% (4.9% passive ideation only, 3.5% active ideation with or without a plan or attempt). A total of n = 6 professionals attempted suicide in the past 30 days. In adjusted models, 30-day STB remained significantly associated with pre-pandemic lifetime mood (odds ratio [OR] = 2.92) and anxiety disorder (OR = 1.90). Significant modifiable factors included a perceived lack of coordination, communication, personnel, or supervision at work (population-attributable risk proportion [PARP] = 50.5%), and financial stress (PARP = 44.1%). Conclusions and Relevance: Thirty-day STB among hospital workers during the first wave of the Spain COVID-19 outbreak was high. Hospital preparedness for virus outbreaks should be increased, and strong governmental policy response is needed to increase financial security among hospital workers. Fondo de Investigación Sanitaria, Instituto de Salud Carlos III (Ministerio de Ciencia e Innovación) /FEDER, Grant/Award Number: COV20/00711; ISCIII, Grant/Award Number: Sara Borrell, CD18/00049, PFIS, FI18/00012; FPU, Grant/Award Number: FPU15/05728; Generalitat de Catalunya, Grant/Award Number: 2017SGR452 Sí

Published
2021

10. Mental Health Impact of the First Wave of COVID-19 Pandemic on Spanish Healthcare Workers: a Large Cross-sectional Survey

Author

Alonso, Jordi, Vilagut, Gemma, Mortier, Philippe, Ferrer, Montse, Alayo, Itxaso, Aragón-Peña, Andrés, Aragonès, Enric, Campos, Mireia, Cura-González, Isabel D., Emparanza, José I., Espuga, Meritxell, Forjaz, M. Joao, González-Pinto, Ana, Haro Abad, Josep Maria, López-Fresneña, Nieves, Salázar, Alma D. Martínez de, Molina, Juan D., Ortí-Lucas, Rafael M., Parellada, Mara, Pelayo-Terán, José Maria, Pérez-Zapata, Aurora, Pijoan, José I., Plana, Nieves, Puig, Maria Teresa, Rius, Cristina, Rodríguez-Blázquez, Carmen, Sanz, Ferran, Serra, Consol, Kessler, Ronald, Bruffaerts, Ronny, Vieta, Eduard, Pérez-Solà, Víctor, and Universitat Autònoma de Barcelona

Subjects
Adult, Male, medicine.medical_specialty, Necesidad de atención, MINDCOVID Working group, Adolescent, Cross-sectional study, Health Personnel, Adverse Mental Health, COVID-19 pandemic, Pandemia de COVID-19, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Prevalence of mental disorders, Trabajadores de la salud, Health care, Prevalence, medicine, Humans, Need for Care, Psychiatry, Disability, Salud mental adversa, business.industry, Mental Disorders, Healthcare Workers, COVID-19, Panic, General Medicine, Middle Aged, medicine.disease, Mental health, 030227 psychiatry, Occupational Diseases, Substance abuse, Psychiatry and Mental health, Mental Health, Cross-Sectional Studies, Mood, Trastornos mentales, Spain, Discapacidad, Anxiety, Original Article, Female, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

IntroductionHealthcare workers are vulnerable to adverse mental health impacts of COVID-19. We assessed prevalence of mental disorders and associated factors during the first wave of the pandemic among healthcare professionals in Spain.MethodsAll workers in 18 healthcare institutions (6 AACC) in Spain were invited to a series of online surveys assessing a wide range of individual characteristics, COVID-19 infection status and exposure, and mental health status. Here we report: current mental disorders (Major Depressive Disorder-MDD- [PHQ-8≥10], Generalized Anxiety Disorder-GAD- [GAD-7≥10], Panic attacks, Posttraumatic Stress Disorder –PTSD- [PCL-5≥7]; and Substance Use Disorder –SUD-[CAGE-AID≥2]. Severe disability assessed by the Sheehan Disability Scale was used to identify “disabling” current mental disorders.Results9,138 healthcare workers participated. Prevalence of screen-positive disorder: 28.1% MDD; 22.5% GAD, 24.0% Panic; 22.2% PTSD; and 6.2% SUD. Overall 45.7% presented any current and 14.5% any disabling current mental disorder. Healthcare workers with prior lifetime mental disorders had almost twice the prevalence of current disorders than those without. Adjusting for all other variables, odds of any disabling mental disorder were: prior lifetime disorders (TUS: OR=5.74; 95%CI 2.53-13.03; Mood: OR=3.23; 95%CI:2.27-4.60; Anxiety: OR=3.03; 95%CI:2.53-3.62); age category 18-29 years (OR=1.36; 95%CI:1.02-1.82), caring “all of the time” for COVID-19 patients (OR=5.19; 95%CI: 3.61-7.46), female gender (OR=1.58; 95%CI: 1.27-1.96) and having being in quarantine or isolated (OR= 1.60; 95CI:1.31-1.95).ConclusionsCurrent mental disorders were very frequent among Spanish healthcare workers during the first wave of COVID-19. As the pandemic enters its second wave, careful monitoring and support is needed for healthcare workers, especially those with previous mental disorders and those caring COVID-19 very often.

Published
2020
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14. Prediction of liver iron overload in the Basque country (Spain) in patients referred for hyperferritinemia

Author

Castiella, Agustin, primary, Urreta, Iratxe, additional, Zapata, Eva, additional, Alústiza, José M., additional, de Juan, Ma Dolores, additional, Emparanza, José I., additional, Zubiaurre, Leire, additional, Castiella, Agustín, additional, Iribarren, Arantxa, additional, Mendarte, Usua, additional, Bujanda, Luis, additional, Muro, Nerea, additional, Ibarra, Begoña, additional, de Juan, M. Dolores, additional, Salvador, Emma, additional, Otazua, Pedro, additional, de Juan, Aitor, additional, Letamendi, Garazi, additional, Arrizabalaga, Beatriz, additional, and Rincón, Maria Luisa, additional

Published
2021
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18. Prediction of liver iron overload in the Basque country (Spain) in patients referred for hyperferritinemia

Author

Zubiaurre, Leire, Zapata, Eva, Castiella, Agustín, Iribarren, Arantxa, Mendarte, Usua, Bujanda, Luis, Muro, Nerea, Ibarra, Begoña, de Juan, M. Dolores, Urreta, Iratxe, Emparanza, José I., Alústiza, José M., Salvador, Emma, Otazua, Pedro, de Juan, Aitor, Letamendi, Garazi, Arrizabalaga, Beatriz, Rincón, Maria Luisa, Castiella, Agustin, and de Juan, Ma Dolores

Published
2021
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19. Body mass index and alcohol consumption are directly related with liver steatosis. Results from a prospective study of patients referred for hyperferritinemia

Author

Zubiaurre, Leire, Zapata, Eva, Castiella, Agustín, Iribarren, Arantxa, Mendarte, Usua, Bujanda, Luis, Muro, Nerea, Ibarra, Begoña, Dolores de Juan, M., Urreta, Iratxe, Emparanza, Jose I., Alústiza, Jose M., Salvador, Emma, Otazua, Pedro, de Juan, Aitor, Letamend, Garazi, Arrizabalaga, Beatriz, Rincón, Maria Luisa, Alústiza, José Mª, and Emparanza, José Ignacio

Published
2020
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24. Measurement of Liver Iron Concentration by MRI Is Reproducible

Author

Alústiza, José María, primary, Emparanza, José I., additional, Castiella, Agustín, additional, Casado, Alfonso, additional, Garrido, Adolfo, additional, Aldazábal, Pablo, additional, San Vicente, Manuel, additional, Garcia, Nerea, additional, Asensio, Ana Belén, additional, Banales, Jesús, additional, Salvador, Emma, additional, Moyua, Aranzazu, additional, Arozena, Xabier, additional, Zarco, Miguel, additional, Jauregui, Lourdes, additional, and Vicente, Ohiana, additional

Published
2015
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25. Alveolar nitric oxide and its role in pediatric asthma control assessment

Author

Pediatría, Pediatria, Sardón Prado, Olaia, Corcuera, Paula, Aldasoro, Ane, Korta Murua, José Javier, Mintegui, Javier, Emparanza, José I, González Pérez-Yarza, Eduardo, Pediatría, Pediatria, Sardón Prado, Olaia, Corcuera, Paula, Aldasoro, Ane, Korta Murua, José Javier, Mintegui, Javier, Emparanza, José I, and González Pérez-Yarza, Eduardo

Abstract

Resumen Background: Nitric oxide can be measured at multiple flow rates to determine proximal (maximum airway nitric oxide flux; Jaw(NO)) and distal inflammation (alveolar nitric oxide concentration; CA(NO)). The main aim was to study the association among symptoms, lung function, proximal (maximum airway nitric oxide flux) and distal (alveolar nitric oxide concentration) airway inflammation in asthmatic children treated and not treated with inhaled glucocorticoids. Methods: A cross-sectional study with prospective data collection was carried out in a consecutive sample of girls and boys aged between 6 and 16 years with a medical diagnosis of asthma. Maximum airway nitric oxide flux and alveolar nitric oxide concentration were calculated according to the two-compartment model. In asthmatic patients, the asthma control questionnaire (CAN) was completed and forced spirometry was performed. In controls, differences between the sexes in alveolar nitric oxide concentration and maximum airway nitric oxide flux and their correlation with height were studied. The correlation among the fraction of exhaled NO at 50 ml/s (FENO50), CA(NO), Jaw(NO), forced expiratory volume in 1 second (FEV1) and the CAN questionnaire was measured and the degree of agreement regarding asthma control assessment was studied using Cohen's kappa. Results: We studied 162 children; 49 healthy (group 1), 23 asthmatic participants without treatment (group 2) and 80 asthmatic patients treated with inhaled corticosteroids (group 3). CA(NO) (ppb) was 2.2 (0.1-4.5), 3 (0.2-9.2) and 2.45 (0.1-24), respectively. Jaw(NO) (pl/s) was 516 (98.3-1470), 2356.67 (120-6110) and 1426 (156-11805), respectively. There was a strong association (r = 0.97) between FENO50 and Jaw(NO) and the degree of agreement was very good in group 2 and was good in group 3. There was no agreement or only slight agreement between the measures used to monitor asthma control (FEV1, CAN questionnaire, CA(NO) and Jaw(NO)). Conclusions: The re

Published
2014

26. Novel equation to determine the hepatic triglyceride concentration in humans by MRI: diagnosis and monitoring of NAFLD in obese patients before and after bariatric surgery

Author

Jiménez-Agüero, Raúl, primary, Emparanza, José I, additional, Beguiristain, Adolfo, additional, Bujanda, Luis, additional, Alustiza, José M, additional, García, Elisabeth, additional, Hijona, Elizabeth, additional, Gallego, Lander, additional, Sánchez-González, Javier, additional, Perugorria, María J, additional, Asensio, José I, additional, Larburu, Santiago, additional, Garmendia, Maddi, additional, Larzabal, Mikel, additional, Portillo, María P, additional, Aguirre, Leixuri, additional, and Banales, Jesús M, additional

Published
2014
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34. MR Quantification of Hepatic Iron Concentration

Author

Alústiza, José M., primary, Artetxe, José, additional, Castiella, Agustín, additional, Agirre, Cristina, additional, Emparanza, José I., additional, Otazua, Pedro, additional, García-Bengoechea, Manuel, additional, Barrio, Jesús, additional, Mújica, Fernando, additional, and Recondo, José A., additional

Published
2004
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36. Serum Carboxy-Terminal Propeptide of Procollagen Type I Is a Marker of Myocardial Fibrosis in Hypertensive Heart Disease

Author

Querejeta, Ramón, primary, Varo, Nerea, additional, López, Begoña, additional, Larman, Mariano, additional, Artiñano, Edurne, additional, Etayo, Juan C., additional, Ubago, José L. Martínez, additional, Gutierrez-Stampa, Marian, additional, Emparanza, José I., additional, Gil, María J., additional, Monreal, Ignacio, additional, Mindán, Javier Pardo, additional, and Díez, Javier, additional

Published
2000
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37. The Presence of Mutations in the K-RAS Gene Does Not Affect Survival after Resection of Pulmonary Metastases from Colorectal Cancer.

Author

Zabaleta, Jon, Aguinagalde, Borja, Izquierdo, José M., Bazterargui, Nerea, Laguna, Stephany M., Martin-Arruti, Maialen, Lobo, Carmen, and Emparanza, José I.

Subjects
GENETIC mutation, GUANOSINE triphosphatase, LUNG cancer treatment, COLON cancer, METASTASIS, LUNG cancer patients, NUCLEOTIDE sequencing
Abstract

Introduction. Our objective was to identify mutations in the K-RAS gene in cases of pulmonary metastases from colorectal cancer (CRC) and determine whether their presence was a prognostic factor for survival. Methods. We included all patients with pulmonary metastases from CRC operated on between 1998 and 2010. K-RAS mutations were investigated by direct sequencing of DNA. Differences in survival were explored with the Kaplan-Meier method log-rank tests and multivariate Cox regression analysis. Results. 110 surgical interventions were performed on 90 patients. Factors significantly associated with survival were disease-free interval (P = 0.002), age (P = 0.007), number of metastases (P = 0.001), lymph node involvement (P = 0.007), size of the metastases (P = 0.013), and previous liver metastasis (P = 0.003). Searching in 79 patients, K-RAS mutations were found in 30 cases. We did not find statistically significant differences in survival (P = 0.913) comparing native and mutated K-RAS. We found a higher rate of lung recurrence (P = 0.040) and shorter time to recurrence (P = 0.015) in patients with K-RAS mutations. Gly12Asp mutation was associated with higher recurrence (P = 0.022) and lower survival (P = 0.389). Conclusions. The presence of K-RAS mutations in pulmonary metastases does not affect overall survival but is associated with higher rates of pulmonary recurrence. [ABSTRACT FROM AUTHOR]

Published
2014
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38. Intrafamilial Spread of Hepatitis C Virus Infection

Author

García-Bengoechea, Manuel, primary, Cortés, Alicia, additional, López, Pilar, additional, Vega, José L., additional, Emparanza, José I., additional, Sarriugarte, Angel, additional, Santos, Eva, additional, and Arenas, Juan I., additional

Published
1994
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39. Thirty-day suicidal thoughts and behaviors among hospital workers during the first wave of the Spain COVID-19 outbreak.

Author

Mortier P, Vilagut G, Ferrer M, Serra C, Molina JD, López-Fresneña N, Puig T, Pelayo-Terán JM, Pijoan JI, Emparanza JI, Espuga M, Plana N, González-Pinto A, Ortí-Lucas RM, de Salázar AM, Rius C, Aragonès E, Del Cura-González I, Aragón-Peña A, Campos M, Parellada M, Pérez-Zapata A, Forjaz MJ, Sanz F, Haro JM, Vieta E, Pérez-Solà V, Kessler RC, Bruffaerts R, and Alonso J

Subjects
Disease Outbreaks, Hospitals, Humans, Prevalence, Risk Factors, SARS-CoV-2, Spain epidemiology, Students, Suicide, Attempted, COVID-19, Suicidal Ideation
Abstract

Background: Healthcare workers are a key occupational group at risk for suicidal thoughts and behaviors (STB). We investigated the prevalence and correlates of STB among hospital workers during the first wave of the Spain COVID-19 outbreak (March-July 2020)., Methods: Data come from the baseline assessment of a cohort of Spanish hospital workers (n = 5450), recruited from 10 hospitals just after the height of the coronavirus disease 2019 (COVID-19) outbreak (May 5-July 23, 2020). Web-based self-report surveys assessed 30-day STB, individual characteristics, and potentially modifiable contextual factors related to hospital workers' work and financial situation., Results: Thirty-day STB prevalence was estimated at 8.4% (4.9% passive ideation only, 3.5% active ideation with or without a plan or attempt). A total of n = 6 professionals attempted suicide in the past 30 days. In adjusted models, 30-day STB remained significantly associated with pre-pandemic lifetime mood (odds ratio [OR] = 2.92) and anxiety disorder (OR = 1.90). Significant modifiable factors included a perceived lack of coordination, communication, personnel, or supervision at work (population-attributable risk proportion [PARP] = 50.5%), and financial stress (PARP = 44.1%)., Conclusions and Relevance: Thirty-day STB among hospital workers during the first wave of the Spain COVID-19 outbreak was high. Hospital preparedness for virus outbreaks should be increased, and strong governmental policy response is needed to increase financial security among hospital workers., (© 2020 The Authors. Depression and Anxiety Published by Wiley Periodicals LLC.)

Published
2021
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